Council for Tobacco Research
Pulmonary Eistopathology of Hamsters Exposed to Smoke [Histopathological Findings of Study of Hamsters Exposed to Cigarette Smoke]
Fields
- Master ID
- Ctrmn00041967-2810
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- Author
- Bernfeld, P., Bioresearch Consultants
- Homburger, F., Bioresearch Consultants
- Russfield, A.B., Bioresearch Consultants
- Homburger, F., Bioresearch Consultants
- Depository Date
- 08 Sep 1997
- Box
- 267
- Type
- SCIENTIFIC REPORT
- UCSF Legacy ID
- zmt30a00
Document Images
\
_C:
P(.ZMO4ARY EISTOPAT2iOLOGY OF H.A"LSTERS E?C'sOSED TO SM0KE-I
Paper presented at Society of Toxicology !!eeting, Nev York, March 16-22, 1?7?
F. Hocburger, A.B. Russfield, and P. Bernfeld, BioReseazcn Consultants,
Inc., CaJbridge, Hassac'sesetts.
h% ARE RrPOSTING A.Y EXPERIt+Z`iT IN W'HICH PASSIPi C-GARETTE SY.O:r'
IN"AAL,ITION IN I?1Br.ZD S!'atTAN F'.ADLSTERS, WITH M7TUCAC R.:FER-:I:CE CIG.IRETTES, WAS
FOLLOWED BY NEOPLPS_"IC CHANGES IN RESPIRATORY EPITR=LIOD4 OP THE LAR-"NX: IN ADDITIO\,
lA.LIGTaNT 27,1SOP.3AR:fNG=z?. TUMORS OCCITLR=D IN TWO SNO.X---EXPOS:D A.NL`RiS .
irc: CEiOSE SYR?:V FmSPERS FOR TOBACCO SMOKE FY2OSUR?. STUDIES BEC.+USE
OF T=rIR P-'.SIb?TV%ZCE TO NIC7:I1. AND TO S.`:O:^_ TOXICITY. T~:S IS _cP.'.:_~'-LL°_
P30NCU.ICD IN C=i2\ '=ti3R£.D STR.L'LIS, TWO OF NY.ICH SELECTED FOR T.°.:S tiO3L`C. I:7
ADDITION, H:.YSTiRS ARE RELATIVELY PZSISTANT TO PGZ"J::i2f i~: ECTIONa Wr:: : AR=
COa`tC-N IN OT.Y.ER RODENTS ?VD SPOti:P~ ~O.S RESPIPATORI' TRACT trTOPL.tSYS A.°: A RAPS^!'.
ON TF' CThc'. I::S7I:..:.ATICNn 0° %^.S.R:OCS C.ZRCa.7Cf=7S 'r_.vc
tF=A:'EC:.Y C_°>!:NS7?aT: D>!:NS7?aT:D OF TEr E20STIR'S R°S?iSta^O?_' °_?IT
^O CzT:!IC... l:<7
F==D .a
:S TF= T:i~ __ iii=S FAPE? STGvESTS. T:IS ?~5~._:.^IOS 'n~._ ~~
P?_y_ARI:Y H:STOP.ITHJLGGICAL F. I7IVGS C- THIS 57C7::'! :~:. := BASED
O.`: EX;L`:=::=^.:JI: CF OF Tet<S '.`::K4LS IN THIS ?:CJSC^_. TF= :F_°
STILL BEING ?RG=S-D Y'R Fi:STOPa:'fi^LCGv.
IN A CDFC'.lRJ.:_ STUDY FlHICH E REPORTED L': A RSC-.i CJaTL?=':'_ .~ D
AT NIH, !X:^=Nri:L:. US_::'a RAaLON-8RED EkMSTERS AND CIG7tim..::._5 SXO:CD I\- F:IS 04+::
N_aCHI :'f.' 035ERVED-10.6i .,.:,.~Y::G EAL IESIC!:S WHICH HE JCJCi.D TO BE I:7CI?I= :: !'
IN~?.S:'v=
THOUGH :IC..7E CF TiiE:! FsT:STASI5E0 AND NCNE SdER3 F.1TA:. TO TxE T=m INCIC=`7C
I':his ir.ves:ic,a:io- was sU =o^ted by Co-tract No. S of The Council :or Tcbacco
Research - U.S.A., Inc. Cpiniols ex_ressed by the aut1hors are not r.e%-essarile t`sose of the
s?orsor.
CTR coNTRRCTS 0056825'
11225424
C"~"' t~~~ 04~ 346
a
/b
OF SDCi LESIONS IN OQR SEP?ES IS !:O: )CYOI+:l pS Y_:. THE HISTOLOG`! OF T*r= LESIC`:S
WHICH WE OBSERVE I~t THE LArZ`~NXES OF SAtOT-E77OSID AH=VS.S, EOhi11EP., AP?i:.RS TO BE
QUITE SIMILAR TO THAT DESCRIBED BY D3NTE~wZLi .
THE PURPOSE OF OUR PAPER IS TO P.LTSEaT YINDI:.`GS YJ4DE LY TS40 LIN..TS
OF INBRED SYRIAN H.a.vSTERS EJC~OSED :`O CIGARETTi SHOiC TO AFPORD YOQ A.`i CPPOFL'GtiI:1
TO CO,%I?AR? C'JR FINDIN3S WITP. THOSE REPO:trz-D BY DOVTEtidiLL AND TO EN38J.5: .T'c O?:'T
MORE TE I~,2OTCAD1.r OF THE C}iOIC C3 ANI::1L V TF.IS TYPE OF S:'UDY.
102 INBRED SYRITLV BAYST=?:S OF -'FE 3I0 87.20 AND BIO 15.16 5:::.INS
OF TELACO, BAR HAP3OR, M.AI\c., V*%--', E)O'OSED T:.-CE D.AILY, FIVE DAYS A NE=Y TO EIC='P
PUFFS FRO!1 K=.NiJC<'! 1R1 CIG.L2:a::S DF ^.:rJ-SSCO:D DCiF.?CION TA?C\ sti~R: K::-~i3 5':
A WALT06N-:?7Rn-SSEY .'v' V=?SS S:!OCR. TFO. E:r'0SUTi° ^:0 ABC7CTC 19% S?:O:C CON'G\iF.4TIt~'
LASTED 15 ST-CO~:S }L.'D W.aS FOLT..C:+ZD 3Y 43 SECC\DS OF LA°OZ.TOR'! A_R. S:k:Y
CF E:.C1{ ST?AIV hTR; F'rLC IN CAO=S ~=T'1.CVS `li_:I?v1?IOY AND 60 ADDII:C::?i,
O' :Ar:= S:?:.=\ `nz-ti: AS i:- A::=!.:~L5 EXC?' =-k. ...
.t?J INS-=.. I:::7 .-_ _.. '7fT S:':/ 87.20
}4'LI--D .._ .: n3=v5. .?77 C? .- 3-? 15.16 e.^ 48 ?\D 7S
DYING E v`-?.7'cI~SLY i~:3 ;.:zJ Sav:-_D H.aCi__G:_ LY. ISI t.`_._:D':'v S'!OKT.,
AA iCi _~^~ C:USTEi-S C
.-'! :. 87.20
L'; i~T \157=:'.~4Y : C5 CF
5::~~-=rC =D 1°.lc A: :>ir . C'it ;.ISn=S~.=.CC::=. r_ C.r=
C:Ft=R F:: AJ=:.OC? SCT.C CARC:\C.''~. C': cPL?S':.' C__;G="~ i-2 5=~ I\ ?_
APP?CX_Y.1^'.C..'_' 40 D=-K5 CF 5".:::G =Y--JSuec. T_SIC.:S JUDG=O 'O B_
INVAS=.~ 8C^. S':ILL %_ZY 5:3.=rS. lT 7-Z FOUND TVE L?~^:!r S CF A 05=.7 ...:.__
OF EAC:i S':'nalV, BEGZ\tiI\G AT AB_U: 80 h==K5 OF :tiIS CC:~FI~`~ Ti
OBSSRY:.3IOLN5 OF DC::TE%-..II.. C:. "%..`^.:GEA.'. C. =._'S. SS ?n-* C?L I'O\ 50~- ..r..:GIS ..=..D
- 2 -
CTR CC3NTRaCTS 005684
11225425
CT R tll N 0 4 22 3- 47
BE USED IN A~P.'.ICATT_OVS OF THIS -~^yMS:cR I v'i:,:ATIC:: MODEL FOR STL'D^S =' BIC:ACICA_
ACTIVITY OF WOLE £NOiC .
Slides
S+y' NAVE EST.La'..ISeiD TtC FE:SIBILITY OF TR3':SPIAh3'ING, GRONI\G T_ID
SERIALLY TfvLVSP*_.AYT21G SMOKE EXPOSED Ed?_KSTER LARri7CS IN Th?. CP.£EY POCCEES OF
ANI!?ALS OF TFM SA4-- STFi.lIN. TFIS tL1Y PERMIT TEST OF THESE TISS~it,'S FOP. 11,1-T IC.`tAVCY.
TrsT.. DIFF=LT\CES IN r.-:E P.z'SP9NSES OF THE TWO STRAINS OBSEnVED SO
FAR, NAIM=LY DIFFEP-z-S: PZSISTA`:=- T'J NICC/_`INE AND SNaC.T, DIFFERE:2':' CFLP\=S
AND Dcrc_Fz:%1 r_4CiJ.? F-? z= ?L'SPGXS_, ILLUB?R?.TE ^"A" ^KE SEr-ECTIOT OF T:=
H:LL .1FFECT T1E OL=CO!rM OF A\ E?C? RI ~:^_ . OF CO:RiE, IT IS PTEL:. :C`:C:tE TPJ.^. T:?'
PESFCi:S'tS ^0 "CAY"..S\r-1cI^:IC VAFii T_NCQ`!CUSLY AMOA`IG A`7I%a: SraC ~5 ii:^ S:iv\I::S
AND AR-' FII~'?.£R At==C:ED :C CCt:C=^.IC:I:::G IT:FL'v'ENCZE'a IN AND ON TFZ
INDI'.=L'J.~
CN:ly A =AS SE: i J41^E L?iD-cCST?.VDI_`7G T_ CC}P_i.
.'_^OPS T=.-._ T'rE== DI:iC'.=.\=S .:ID
C:: cCN*-FLL:_.: :ry.
?CSS:3=
?=SPC.:S-° ?_`:.'. ... C
TE?C{4_ OF .r._ :.;RY^.:X L`: C°_SIF.:=D .`=AS:?.SI: ARE U~DEi :=Y.
- 3 -
CTR CONTRRCTS ooJ6es
11225426
C TRMN 0~~~~~~~
a
/h
Society c_° Toxicolcef meet:r.c. !!a:c:' 19'3
Leacnds of slides
1. Differences in toxicity of LD/50 of intraperitoneal nicotine A--'crate
in mice, rats hamsters
2. Tex:city of cigarette sr,oke
3. Effects of s=oke exposure upon body weight in 87.20 haaste:s
4. Ef:ects of smoke Qx_r.osuse u:en body weight in 15.16 haaste:s
5. S--vival of 67.20 hamsters with en3 without snoke exxsuse
6. S,_-vival of 15.16 hamsters with an3 vit:iou= s=oke exxs_e
7. Eas1v s=::z=ars ae'a_lasia of 92 v:<s.
6. 54ua.:.ous neta?lzia of trac.`.ec, 15.16, 73 wks.
9. :a::: tra:heal :zt:_lcna, nale 15.1E, 92 wk:.
_:. t s~ cas _a=i1-os of trachea, ea'_e :5.=6, i3 uks.
sac:<ad :.a.s:e=, 27.2C
'a_e _.._ , 7i wka.
:5.'_6, e:
s+ks.
:e1a. _ -x, r..a?e 67._:. 60
..a1e e: wi, s .
_'. :_euccer:=:e'?;ca-ocs h~perplasia, rale 6'.i~. 6_ .:ca.
:E. Pseucoepit_':e1icma-e_s hvpe:rla_sia, r.s1e 15.::. 6: w:cs.
19. Fseudoep't_.elionetous hyperplasia, ?Ca, eale 15.16, 92
20. l.a:vrx: 1_ynceal ir.cipient ctcinor.a, 15.1E, ma:e *63, 97 v'a.
Ncte sub=_cosa1 1rsciatics w:it:. tu.=cs cells.
21. Eiyh _owe_ of 20.
22. L;1-`atic or capilla:y with i=zinqi-? ttr,-o:
23. Lt_-yr.x: larvnceal ir.cipient carcincr..a, 15.1:. =_e i93, 97 -.:.
5.:b-c::osa1 ir.:as:cn.
CTR cONTRRCTS 005686
11225427
CTR ~-I~~~ 04~~~4 RE
I
24. Hicn power of 23.
25. Suboucvsal lyn.s,atic with tuz.or
26. Nasopha_rynx ader.oc_+stic t%mor, eula 15.16, 70 w',cs.
27. Nasoohary:uc, sarcomttous tuar, nale 15.16, 73 wks.
28. Same animei, pseucoepithelionatous hherp lasia, 1ax-f:uc,
15.16, 73 w;cs.
29. Same azi^z:, lurq aetastasis
,
CTR CaHTRRCTS 0~~661?
11225428
CTR IMIN 04223-50
