Council for Tobacco Research
[Agreements Between Ctr and Bioresearch Institute and Bioresearch Consultants]
Fields
- Depository Date
- 08 Sep 1997
- Master ID
- Ctrmn00041967-2810
Related Documents:- CTRMN041967-2114 Deposition of Freddy Homburger, M.D. [Deposition of Homburger in the Matter of Broin]
- CTRMN042115-2200 Deposition of Freddy Homburger, M.D. [Deposition of Homburger in the Matter of Broin]
- CTRMN042201-2213 Chronology of Events [Letters and Chronology Outline Dispute Over Publishing Research on Cigarette Smoke and Hamsters]
- CTRMN042214-2228 Inhalation Carcinogenesis Experimental Investigations on the Effect of Cigarette Smoke Inhalation on Small Laboratory Animals [St Effects of Long-Term Exposure to Tobacco Smoke on Small Animals]
- CTRMN042229-2248 [Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters]
- CTRMN042249-2251 [Comments and Suggestions on Study Titled Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters]
- CTRMN042252-2269 Strain Differences in the Response of Inbred Syrian Hamsters to Cigarette Smoke Inhalation Journal of the National Cancer Institute, Vol. 53 [St Cigarette Smoke Caused More Cancer in One Strain of Hamsters Than Another]
- CTRMN042270-2294 Progress Report for the Current Contract Period and Renewal Application (with Budget) of the Project Entitled the Determination of the Usefulness of the Golden Syrian Hamster As Model Animal for Inhalation Studies [Cigarette Smoke Inhalation Caused Macrophages in Some Hamsters' Lungs and Reduced Weight Gain But Did Not Affect Mortality]
- CTRMN042295-2298 [Summary of Meeting on Status of Research]
- CTRMN042299-2304 [Draft of Contract for Inhalation Studies in Syrian Hamsters]
- CTRMN042305-2308 [Comments From Counsel About Contract Form]
- CTRMN042317-2345 Skin Painting Studies in Syrian Hamsters Skin Painting Techniques and in Vivo Carcinogenesis Bioassays Progress in Experimental Tumor Research, Vol. 26 [St Skin Painting Caused Tumors in Hamsters More Frequently Than in Mice]
- CTRMN042346-2350 Pulmonary Eistopathology of Hamsters Exposed to Smoke [Histopathological Findings of Study of Hamsters Exposed to Cigarette Smoke]
- CTRMN042351-2403 [Expanded Study of Mouse Skin Exposure to Whole Fresh Smoke Condensate Compared to Skin Painting Final Report]
- CTRMN042404-2405 [Ctr Delaying Approval for Continuation of Smoke Inhalation Studies Seeks Guidance in Procuring Funding]
- CTRMN042406-2406 Bio Research Consultants, Inc. Consultants to the Tobacco Industry Since 1959, Is Now Offering A New Technology-- A Fresh Smoke Inhalation Method [Offering Smoke Inhalation Studies to Tobacco Industry]
- CTRMN042407-2422 [Results and Methods of Bioresearch Consultants' Studies Are Property of Ctr Inhalation Studies with Cigarette Smoke]
- CTRMN042423-2423 [Disputes Claim That His Actions Are Breach of Contract]
- CTRMN042424-2424 [Suggests Meeting with Hockett and Jacob Before Presenting Paper]
- CTRMN042425-2425 [Summarizes Conversation Publish Scientific Data But Clarify Source of Interpretations and Ownership of Patents]
- CTRMN042426-2426 [Abandon Bulletin on Inhalation Studies with Cigarette Smoke Delay Involving American Society for Testing Materials One Year]
- CTRMN042427-2427 [Abandon Bulletin on Inhalation Studies with Cigarette Smoke Delay Involving American Society for Testing Materials One Year]
- CTRMN042428-2473 [Manuscript on Strain Differences in the Response of Inbred Syrian Hamsters to Cigarette Smoke Inhalation Submitted for Approval to Publish]
- CTRMN042474-2552 "Final Report on Contract C-191 A Project Entitled "the Determination of the Usefulness of the Syrian Golden Hamster As Model Animal for Inhalation Studies"" [75 Weeks' Exposure to Cigarette Smoke Produced Various Results in Hamsters, Including Macrophages in the Lungs, Increased Heart and Lung Weights, and Decrease in Body Weight]
- CTRMN042553-2553 [Encloses Assignment for Patent No. 3528435 Seeks Direction in Withdrawing Paper at Federation Meeting]
- CTRMN042554-2554 Sugar in Tobacco [Deplores Speculation in Tobacco Controversy Reports on Successful Studies of Smoke Inhalation with Hamsters]
- CTRMN042555A-2555 Fluoride Ion Excretion After Inhalation of Several Fluoroethylene Derivatives [St Exposing Rats to Atmospheres of Fluorinated Ethylene Compounds Increased Urinary Excretion of Fluoride Ions]
- CTRMN042555B-2555 Pulmonary Histopathology of Hamsters Exposed to Smoke [St Exposing Hamsters to Cigarette Smoke Resulted in Effects on Pulmonary System]
- CTRMN042555C-2555 Response of Rats to Pyrolysis Products of Fluorinated Polymers [St Physiological Responses of Rats to Pyrolysis Products Included Diuresis]
- CTRMN042556A-2556 Tumor-Associated Alkyldialacylglycerols (Adag) and Other Lipids in the Thymus During Irradiation-Induced Leukemogenesis Pathology 2202 [St Analysis of Tumor-Associated and Other Lipids in Mice Following Radiation Doses]
- CTRMN042556B-2556 the Endocrine Role of Dietary Lipids in Mammary Tumor Formation Pathology 2203 [St Mice Fed Lipids to Determine Effect on Tumor Development]
- CTRMN042556C-2556 Effects of Altered Dietary Fat Intake on Serum Prolactin Titer Pathology 2204 [St High Fat Diet in Rats Resulted in Increased Serum Prolactin Levels]
- CTRMN042556D-2556 Altered Incorporation of 3h-Thymidine in Hamster Tracheal Epithelium Caused by Respiratory Carcinogens Pathology 2205 [St Hamster Research Suggests That Dna Damaged by Respiratory Carcinogens in Vitro Can Be Repaired]
- CTRMN042556E-2556 Histopathology of Respiratory System of Bio 15.16 Hamsters Chronically Exposed to Cigarette Smoke [St Hamsters Exposed to Smoke Had More Pathological Lesions in Their Larynxes]
- CTRMN042556F-2556 Peritoneal Mesothelioma Pathology 2207 [St Study of Patients with Symptoms of Peritoneal Mesothelioma]
- CTRMN042557-2573 Strain Differences in the Response of Inbred Syrian Hamsters to Cigarette Smoke Inhalation Journal of the National Cancer Institute, Vol. 53, No. 4 [St Smoke Exposure Resulted in Reduced Body Weight, Enlarged Heart and Lungs, Hyperplastic or Neoplastic Changes in the Larynx, and Microinvasive Cancer in Hamsters]
- CTRMN042574-2591 Experimental Lung Cancer Carcinogenesis and Bioassays Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters [St Smoke Inhalation Produced Hyperplastic Changes in Hamster Larynxes and Decreased Body Weight, But Did Not Affect Mortality Strain Differences Were Pronounced]
- CTRMN042592-2599 ""Smokers' Larynx" and Carcinoma of the Larynx in Syrian Hamsters Exposed to Cigarette Smoke" [St Smoke Exposure Resulted in Cancer of the Larynx and Severe Epithelial Changes in Hamsters]
- CTRMN042600-2603 Homotransplantation of Larynxes of Cigarette Smoke-Exposed Syrian Hamsters (38760) Proceedings of the Society for Experimental Biology and Medicine, Vol. 149 [St Sections of Hamster Larynxes Were Transplanted Into Cheek Pouches of Other Hamsters Hyperplasia Caused by Cigarette Smoke Persisted Up to One Year Without Further Exposure to Smoke]
- CTRMN042604-2626 Differentiations in Cigarettes Off Materials Other Than Tobacco Medicine Et Hygiene, No. 1216 [St Smoke From Cigarettes Made From Cytrel Contains Less Tar Than Tobacco Smoke and No Nicotine]
- CTRMN042627-2670 Advances in Modern Toxicology New Concepts in Safety Evaluation [St Syrian Hamsters Are A Valuable Option for Animal Experiments]
- CTRMN042671A-2673 Detection of Chemical Mutagens Using Concentration Gradient Plates: Observations on Results with 414 Compounds Toxicology and Applied Pharmacology, Vol. 45 [St Discovery of Chemical Mutagens]
- CTRMN042671B-2673 Dominant Lethal Studies in Rats of Five Hair Die Components: 2 Nitro P Phenylenediamine, 4 Nitro O Phenylenediamine, M Phenylenediamine, 2.4 Diaminoanisoic Sulfate, and 2.5 Diaminoanisoic Sulfate Toxicology and Applied Pharmacology, No. 45 [St Weak Lethality Results From Exposure of Rats to Hair Die Components]
- CTRMN042671C-2673 Motor Oil Antagonism of the Effects of So2 on Pulmonary Function in the Guinea Pig Toxicology and Applied Pharmacology No. 45 [St Motor Oils Reduced Irritancy of So2]
- CTRMN042671D-2673 Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters. I: Methods and Dosimetry Toxicology and Applied Pharmacology Vol. 45 [St Hamsters Exposed to Tobacco and Cytrel Cigarette Smoke and Results Noted]
- CTRMN042671E-2673 Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters. II: Histopathological Lesions in the Respiratory Tract Toxicology and Applied Pharmacology, Vol. 45 [St Tobacco Smoke Resulted in Larynx Problems Including Invasive Carcinoma Cytrel Smoke Resulted in Much Less Damage]
- CTRMN042671F-2673 Pulmonary Pathology in Rats Exposed to Marijuana Smoke for One Year Toxicology and Applied Pharmacology, Vol. 45 [St Rats Exposed to Marijuana Smoke Developed Focal Pneumonitis in Proportion to Dosage]
- CTRMN042671G-2673 Studies on the Pulmonary Uptake of Paraquat Toxicology and Applied Pharmacology, Vol. 45 [St Distribution of Paraquat in Rat Lungs Was Not Uniform]
- CTRMN042674-2749 Chemical Carcinogenesis in Syrian Hamsters: A Review (Through 1976) Progress in Experimental Tumor Research, Vol. 23 [St Hamsters Are Useful Experimental Animals for A Variety of Carcinogenesis Studies]
- CTRMN042750-2764 Cigarette Smoke Inhalation Studies in Inbred Syrian Golden Hamsters Journal of the National Cancer Institute, Vol. 65, No. 3 [St Cancer Was Developed in Hamsters Exposed to Tobacco Smoke Cancer Rates Were Proportional to Smoke Concentration and Tobacco/Cytrel Ratio in Cigarettes]
- CTRMN042765-2769 Cigarette Smoke-Induced Cancer of the Larynx in Hamsters (Cinch): A Method to Assay the Carcinogenicity of Cigarette Smoke Progress in Experimental Tumor Research, Vol. 24 [St Hamster Experiments Are Valid Assay of Tobacco Smoke Carcinogenesis]
- CTRMN042770-2772 in Vivo Carcinogenesis Testing Toxicologic Pathology, Vol. 7, No. 1 [St Smoke-Inhalation Experiments with Hamsters Are Quantitative Assay Method for Relative Carcinogenicity of Cigarette Smokes]
- CTRMN042773-2782 Carcinogenesis in the Upper Aerodigestive Tract [St Carcinogens Such As Tobacco Applied to Mucous Membranes Result in Multiple Tumors Which Are Difficult to Treat]
- CTRMN042783-2787 Subchronic Cigarette Smoke Inhalation Studies in Inbred Syrian Golden Hamsters That Develop Laryngeal Carcinoma Upon Chronic Exposure Journal of the National Cancer Institute, Vol 71, No. 3 [St Smoke From All-Tobacco Cigarettes Caused More Respiratory and Larynx Problems Than From Cellulose-Derived Tobacco Supplement Cigarettes]
- CTRMN042788-2796 A New First-Generation Hybrid Syrian Hamster, Bio F1d Alexander for in Vivo Carcinogenesis Bioassay, As A Third Species or to Replace the Mouse Surv. Synth. Path. Res., Vol. 7 [St This Strain of Hamster Is Perhaps the Best Suited for Cancer Experiments]
- CTRMN042797-2800 [Comments on Slides From Effects of Smoke on Upper Respiratory Tract]
- CTRMN042801-2802 [Conditions for Approval of Publishing Findings]
- CTRMN042803-2810 [Disputing Ctr's Decision to Discontinue Research Chronology of Research-Related Events]
- Author
- Homburger, F., Bioresearch Inst
- Recipient
- Hoyt, W.T., Ctr
- Type
- LETTER
- CONTRACT
- Box
- 267
- UCSF Legacy ID
- xmt30a00
Document Images
B10-RESEARCH INETITUTt, mconpoR:.-zo
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Mr. W . T. Hoy : Ezecutive Director
The Council for Tobacco Researce - U. S.A.
110 East 59th Street
New York, New York 10022
Dear Mr. Hoyt:
~. >/pr!! U ri! t X D. D:rr.rc
Y.lEANFtIP. f~0. ~..c>r!. 4rwa>ai.
June 19, 1970
Enclosed are two signed copies of each of the agreementa the
Bio-Research instin.:te (cortract .`:o. 4) and Bio- Researc_ Coa!=?:a=ts
(t;sntr:ct N-a. 5).
I shall b_ at your o_*ice on "'ues=ay, June 2:, at 11 a.zn. to dis:uss
some of the ad-atzistrative details and other ?ec3img rnazte:s ac :i
you and Dr. ! iss.rti.
lritn rnanv ths.nks ic= these co :trac:s aa? ~:ah `est reprds,
T"t_:dr . _
Er.closu:es
Yours sinctrely,
. ~
Frecdy :?o rl~c;~:- ?.'. D.
Prer.=en: and
t
IwoLrLnoulT ~ Y~:,rnG!.^.
OprRAr[o £[ZYSIVtIT fOR S=I:`:TiI:C A:.r CDUCaT:CtIdL *U11PClff
CTR CCINTE2RCT5 005617
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AGR:Ea..~'IIT SET.7:EN
THE COUHCIL FOR TOBACCO R.SEXP.C'-: - U.S.A.
AND
BIO-R.SEARCFi CDNSCLTl.ATS. I::C.
This agreement covers research to be pes=o_-xd by Hio-Research
Consultants, Inc. according to protocols aste`~iisherd Dy The Coun=il for
Tobacco Fssearc! - U.S.A. and dated June 1, 1970. It is agzcad that the
total charges for the stud:es accordins to these pr:txols will not eY.eed
$75,000.00 for the tr:elve-oonth period be;innir=, Jz:.e'1. 1970. t:e prok-ose
to nake paya.ant to Bio-casearch Consultants, Inc. on a czarterly basis
within twenG,
.! (20) days of receipt of erm invoice de:aili:,g char9es incurred
u.sde= the protocols. in no e.,ent shall r.e pay xre =iatn r.!net; (40t) ie:ceat
of the charges unfer the protocols prior to receip_ of a ce-,:,ltte re=.;:t
coverir.g thc 12-cooth period. Final pr.l'cent will te rade afte_ arprova_ by
The Coum:.il's E:<ec~tive Director o`- this eo--Plete re;:ort r-verinq the
12-v.cnth period. It is agreed that a 12-mont3 re?:r: will be sub:it_e3 tc
The Cca-ncil's :aecutive Director or other whc, he rt_.- tasi=:.cte.
S: ould any tevietions fron the protocDls sae.,3 na:essa_~y dut :o
results cbserve; e_in; the co---se of the stuc;.:°-r.r._-a::.l Co:stltsr;,
Inc. will r.ct'_f: =ae Co~;-ncil fe_ Tchacco Resa:_::h -..5... A.y p:epose=
char.pe end tzy re.isicn in cost w'-11 be sr:.`it:ed :=r a-:d wi=1 dt:c.-t`_ ==1
w:it:l:' co::=i-:1t`-on a.-.?' aooro:al of Tre.Co*_:a_ :__ _z`a:=: Fscasrc: -_.5..
It is u.-.ee:stead and ag_ecd that a-y -_;e: s-_'s_.~ t:or.s to or c._.ges
in thn =retccol ct i ch either perty te this e=slera' :-' yac reY _eat wii- :e
covere= ty cutue::l, acceotable secarats :zit:c: ad`.t ::a to this a;:ea=s-t, an~
will re:uire t::e a=nroval of The Co_.cil's =xtc-ti:e C=rectar or *thcrs wya=
he rc:i 3esisn ete. -
Shou1= st.y unforeseen clar.ce in circ_sts=css =a}:e i= anpre:::cte
to c`==i or tezinate the study, ir.s C'ca::ca :or :_=ao^ ?saesr;'. -:.S.?..
s::el-_ 'a.e t:e Yri:~ile;,! of doing so Lao- si=ty (6C. days .r_it=tn not_ce to
Sio-R:caarch Ccasu_t;r:ts, Inc. Irn tha a:-ant of an_ s-:c: cr---ailaent uoth
parties sia.l negc: iate retuced charges for t'e r.ecessa^; remainir.g se-rice.
in case of terrSna_ion, no penalty costs or cthsr ea:a:.sos shall bc arsessec'..
All data obtained and all inver.tions, dc ~a_s:=aats, _indings o:
discoveries w:^.ethcr or not oatentable, as:e by Lio-3ssaarch Cc=suitar.ts. In:n in tha course of,
or as a roxult e=, xvri dcr:e under _'.is a;recsit she1i Le
the sola and excl'_:ive preperty of l:hr Co.olcil for =::ac~ Prsearci - C.S.A.
Bic-Dssee=ci: Co:+su'_teunts. Inc. agrees to keep sscre: ~.= xnfi_ential an.,
:nfo:~ticr:, kncwledg4 or data octair..d in cot.necti:: w=:`., or as a rest_t of,
work C:s under this agrea=,ent, and further a?raes =.--_ to use suc::
for itself cr fc.z otherd either directiy or i:+cireo_.::. or diselose it :a a::y
t`ir.: _: arty outside of T!je Council for Teyacco Pases=_: - II.S.a. wit:: _. The
Cru-cil's prior written approval.
cTR c0NTRRCTS 0056 1B
11225359
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P.11 equi^aent. 2ocu_ents, books, records, r.otes or othe= =aarials
or data furrisl~ec: by or on behalf of The Ccu.icil fer Te:acoo Fasearch - C.S.K.
in coanection with tior< done under this agreer.ier.t ara11 at all tiees be the
propertv of T:.e Co_,cil fc: Tbbecco Research - U.S.A.. erd shalr be retu_:,ed by
Bio-Rese&rch Consultants, Inc. to the recpective oaner as designate_ by The
Council for Tobacco Rese_ ch - G.S.`. at the tezr.inatioc of this eyseemezt, or
at tny time that The Council for Tobacco 3tesearcn - t'.S.l.. nay rea:est.
If the te_--ms of this agreem-snt rse SLtisfaCLOry, please sign and
date both copies c_ this lettes and return one copy tc The Council's Executive
Director.
Sincerely yours,
TEO COV:ICIL FCR T:ZACCO RESE.A.RC: - U.S.A.
T
=xe-uti.e Director
~
P.C~a==o:
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irM COUNCIL F0R TOB3CN RFS=ARCH - U.S.A.
PROK.COL8 &I%'-) F:CFOC PLA.v
F: I =r.
BIO-:LESE?.?.CIi COXSULTaNTS,
Cc-cridse, :Se3a.
for
=r.E Ds*ES ~..--_o.; =' -`~ rss~ ..:~~s or ".= ==L7E.,
Sv--AIltr: :~_._:I?t !::0_.. F02
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This is a 1'ac_-sti, conzidentiel a;se_^eit as eoatair.e= in the
atta;heG forml ccr.=act.
It is ur.de_stood that there will be an official :.onitor lia:son
between the pttiezi as ir.d:cated er.3 a;.:ointed by The Co=cil fo. a^obacco
Rese3rch - U.S.A. MTR-USa1. The renitor o_st be consulted for c,uestions of
procedure and logist3cs before any chances can be honored. The tcnito: liaisorn
will be e=ao:nze= to %:ozk w_th 3ie-P.ese_c.h Conaultants, inc. (s-4;.I) as it
pestains to this pr _a:ed ..:r.:___..
The im4a.a_c:: s_cdy will enc-.pass ebtaair.q irit:al to:_co:oyical
data leading into aex?os.::e, t^e ti^e dira:ic:: to be dete_-ir.e_ by :^e
:.'TR-*-'5=A r+.o=ic-:. T: a ex_ e=inar.;cl desi: n ccntained h4:e'_= will inclu=e :,o
contrcis -- sna:-.-e.rcse= a:.E ca;: ..elc. _:^.e qrouis to be observed be
iaa:a~a'_ c.^.d rair.t_jne`- a_ statist_ctllr v.os%able :e:als at al: t'__as or
L~:=! ---- t`.:-e (: _-- _._ :;=ee-.s-_ o' ..._ C'_-~t-.=.. _._.'o: its r.o..__.._` as r.oz
les> o: ...- -=- ~ z--=-'-s :e: _-_.. =:--ss a:.: o-
lo;i=_-
= rotctci cttT?ne.
c~- --- hJ' OF ?=-n
A. To d9ts =:ne t:s ..:_, :o: the t:~o s_rains of ha=sters -- (li "cs-ce:
s_s:*;)tible" s=: (3l "iar::" or "canes: resis:en :" -- on i:'^.elet?c s of
o'::oles=oke a:.= of -,.e qase:_s ;`asa c: sro;:a =res the "re'e:ence"
ciQ6SLLte. B. To de:ermine o.-n stlec.ed erqars the lonc-ter.m e.:f-ts ef ch:o:.icall;
e::gosir.; tlir~s to ~::ole sra?;e t._ to ;aseou p~eee of s-:_ o: such
ciqa:uttes.
r
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cTR coh(TRACTS 005621
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11225362
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C. To date:=+ne t.tie rep-ciucib`_lizy o: the "Sa=:ic_ti
D. To o3ttiur "tr.eated" a.-iirlia1s for acclit:onal studies su .h as vixvs pro:i lin;
a.-id biochectiical tests as daterr..ined by The CTR-CSa c:c:x.itor.
SUGGrSTEX PTr&`i OF TF?IS STCrDY
A. InhalaGion of tnbacco sao:e stu3ies to be co.^.d~cte-=' using the waito--
Y.orrissey ltacaine.
1. This project will be involved p_i^.a=ily .:i=i W:;ostL:e o= aniot.ls
to whole smc;e nnd latez to the gaseous -+'::rse.
2. ::e ciqa_ette to be us:a will be the ^e:e=e-ce Cigarette --anu=ccture3
by the Lr.iva=sity of Ker.tL=:y.
3. The anisis will be 5y:ian C-1den Fa:ste:s (:4eso=--icetus aurc=_s) .
Sax will be deter-._::e'-.
a) strai-s .:i'.: be usei:
1) ?. -erZy s_-~.. - to =e ce:e:=- --.
2) A L. lAe-_ -~_ be ...- conlt.:~:s:
1) c^.n--s=~':a:.
2) C==e-1e1Z.
4. _~5` va1:as be d:`e:-a'-.si for __:h s-La. us:n; .._ less t_iar:
!i,e le:tls _-- dose :itf i: ai:=,a-s p=:
cc:r,.arao:vs c: az±-.s:s' res: onse to s-3o::e s-d nico:i.^.3.
5. :axL=m-to:e=ttad dose will se =eC._:_:.ed '__ rc:n st-_a o.^n a
c==onic bnsis, inc).__in; d_ati:n of eras_e et varios degrees
of dilu=icr. c: s-oks with c=r ar.d st4df c` blcc-' leve_s of carbon
acnoxide attained a.-id the at?:o:(i-'1 re:a oi CO eli"il-etior..
CTR CQHTRACTS 005622
11225363
C TR IIN 042 ,314,
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6. Lcng-ra,.ce lifetiee (;X-,e:r.ents Wil? :e i=tiate=. ^he er-re^=e::.
aay be ter-mainated whe:: on).v 1/3 c' the er.cse3 Z_tirnals are
survivino_, or net less t:.en 16 _cat:-s. The C?R-GS:A r.cnito= uill
be consulted before t_e exptrir.snt is te_-air.ated.
a) Cbservatio:u will be aaZa on:
1) appeara.%c: of coat, color, eyes.
2) Aeaetions of tninsls,to :zndl:ng.
3) Bod; r-eight at vesily inte:veis-
b) D,._in: t:._ first -rer= a speci e1 ..iil be a^.de cn :.-sters
e.r-_ose3 to s-n::e S:'^.i'_etic::. F.t t=.e i-itia:ic:: of _`.e
p_cy=e., ar.d e::; _ c.on_^s _ne:___`=-= six en:a.il! K_-. -e
sec__ficed fr..w ea:.. croup `o: ,.._ `o11ea_^; ex+_::a__ozs.
1.) Ei.r^.e:1LCai xaasl'te..e :r.
(a) CO c= car!: ::.ryie_=;=o::z :n ~-,loor:.
(b; U_--:_-e ss _aa __-' -- -_--t or
2)
(LI GC_6S
b:G_:1, C:}:E:i.
.
(0 Orsa-. i,!:C-.i_D 4s-z tcia"%
3) Set.icns of tas.e= to .`.s =t_f ....
or
(b) Piz:.i:Lz-y .
(c) Lunc,s and selecte_
4) Se:c_=id se__as cf e_-.:rsla ei_:en at rsndo= u; be
re;vl:edd ;`e CCR-Z75:A ro^it=_ to te sen t .o
eco_ert'°-.; 2cy._etcs:ee, i._ , for vixu: -:c'_'_:e or
tes.s.
CTR CCNTRRCTS 0056223
11225364
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5) ;k.t terr-4r.s=ie:. all L.i.=ls are to be e_t~: siec.
(a) All organs are to be exa-ned ;=ossly.
(b) Lu,:gs Le to be chec)ce3 for tu.-ors.
(c) Pituitaries are to be ex-ir.ed for tc:.czs.
(d) Salacted tissues ase to te sent to the
pathologi st.
B. Re:etit.ion of 5a=fiotti's rodal for induction of squa=aus cell casc:ao..a,
tsing henatite a-nd hydrocazbo:i (`:C: in the EIO 15:16 hrratezs.
1. Intratsa_,eal a-1-.inistzatic.^n of heratite -ait:n BC a.cordi-g __
Saf=io::?.
2. iapotitions w_;h proyress::ely la++e_ eoses cf EC for cetez-_'::at:or. ,
of the "oritr.z" dose.
3. 1:=r~nist:at±on of her%--tite end ::C d-se w__, s=...- _..._-:ss_-
in adcii tior..
4. -.-..:r.:...--_-c- _= he-.a:-:e an: toba.=c= s=._ eo`---s!.*_s
5. Ls=er a=..- :_ -'at:.;_ra:e= si
to hLa:].tE Mi=
CTR CO~~(Tt~acTS 00561~ N
11225365
W TI 4 I ) ) 0]2~.a' w/+ 1S
