Council for Tobacco Research
[Comments and Suggestions on Study Titled Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters]
Abstract
MAR
Fields
- Depository Date
- 08 Sep 1997
- Master ID
- Ctrmn00041967-2810
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- Type
- LETTER
- Recipient
- Homburger, F., Bioresearch Consultants
- Copied
- Sommers
- Bernfeld, P.
- Gardner
- Hoyt
- Jacob
- Ramm
- Bernfeld, P.
- Box
- 267
- Author
- Hockett, R.C.
- UCSF Legacy ID
- rmt30a00
Document Images
W/' TR I I N 042249
A-4 0-7%i
June 3, 1974
Dr. Freddy Bcnbiager
President and Director
Bio-Reietrch.Conaultanta,
Inc.
9 Cc®excial Avenue
Casbsiege, lisssaahusetts
02141
Dear Freddy:
The m"^+"cript, Cigarette :boke Inhalation Stadies in Inbred Syrian
Han.eters by P. Bernfeld, F. Ficmburger and A. B. Russfield, prepared for the
Battelle Seattle Symposium oa imental Re ira Carcin enesis and Bioess
June 23 - 27, haa been revie+rod by oua staff and consultants. C~ Contract Eo. 5.
A composite of the suggestions
and coraaenta received follovs:
*1. Table I, first footnote. It is suggested that the last
three words be deleted since "sicroinrasiye cancer" is
not mentioned elsewhere in the text or legends for figures,
nor in the vpinion of the reviewers, is it supported by
examination of the illustrations.
2. Page 2, line 8. The e=posure of six a"imal sisaltaneoa+ly
is mentioned. It should be borne in mind that the doaage
of smoke received by an individual eniaal may be affected "jy
the number being exposed, on account of differences in the
rate of saoke chamber de;kletion and dilution of the cham-
ber contents by COp aod other exhaled pcodncte.
3. Page 2, line 21. Smoke dilution factor. It should be made
clear that the dilution factor is an estisate on1y. Leakage,
speed and efficiency of mixing saoYe and air and other factors
may introduce inaccuracies. Only direct aeasurement under
operating conditions can give a highly reliable figtre for
concentration of amoYe at the point of iaSalatioa.
4. Page 3, line 2. This estlnate of smoke concentration received
by humaan amakers is a plausible estimate rhich probabl, lies
within the range, but it nast be recognized that iadl.idual
variations are quite large and there is no established arasage"
based on obserrations.
5. Page 6, line 18. The tern 'paeudoepitbeliamatous 2Qpernlasia"
was questioned as to its agpeopeiaten.ss.
CTR CCNTf2RCT5 005740
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1
-2-
6. Page 9, line 9. it is suggested that the phrase "eonsistent vitb
carcincaa" be deleted as noa-contributory.
#7. Page 12, first paragraph. Until the relative dosages of ssote
received respectively into various parts of the respiratasT tracts
of the Bio 15.16, Bio 87.20 and other strains have actnally been
seasured, it setns hazardous to coaclude that differences in
laryngeal response aust be due to differbaees in tisnss susceptibility.
Strain differences in Dalnonary mechaaics such as tidal roluse,
minute voalusie, respiratary rate and erpecisl.ly ability and inclin-
ation to suspend respiration could affect s:oYe dosages in parti-
cular areas.
8. 'iypographical notes:
Page 1, line 2. "Because" rather than "siace".
Page 2, line 1. American u.age (as eontraeted to Baritish) is
to spell alumiaun vithovt an i before n.
With due consideration of these ccmxnts, ve fiad no objection to yoia
publication of this paper in an;y reputable scientific medi:a on the usua.l seientific
responsibility of the authors.
Sincerelq yoias,
RCH:gb' Robert C. Hoclcett, Rs.D.
Research Directcs
cc: Dr. ?. Berateld
bcc: ?rs. See~ers, Gu3_ar, 2?essrs. F.-,-Jacob, Rm.i
CTR CahlTRRCTS 005741
11225482
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