Council for Tobacco Research
Chronology of Events [Letters and Chronology Outline Dispute Over Publishing Research on Cigarette Smoke and Hamsters]
Fields
- Depository Date
- 08 Sep 1997
- Master ID
- Ctrmn00041967-2810
Related Documents:- CTRMN041967-2114 Deposition of Freddy Homburger, M.D. [Deposition of Homburger in the Matter of Broin]
- CTRMN042115-2200 Deposition of Freddy Homburger, M.D. [Deposition of Homburger in the Matter of Broin]
- CTRMN042214-2228 Inhalation Carcinogenesis Experimental Investigations on the Effect of Cigarette Smoke Inhalation on Small Laboratory Animals [St Effects of Long-Term Exposure to Tobacco Smoke on Small Animals]
- CTRMN042229-2248 [Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters]
- CTRMN042249-2251 [Comments and Suggestions on Study Titled Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters]
- CTRMN042252-2269 Strain Differences in the Response of Inbred Syrian Hamsters to Cigarette Smoke Inhalation Journal of the National Cancer Institute, Vol. 53 [St Cigarette Smoke Caused More Cancer in One Strain of Hamsters Than Another]
- CTRMN042270-2294 Progress Report for the Current Contract Period and Renewal Application (with Budget) of the Project Entitled the Determination of the Usefulness of the Golden Syrian Hamster As Model Animal for Inhalation Studies [Cigarette Smoke Inhalation Caused Macrophages in Some Hamsters' Lungs and Reduced Weight Gain But Did Not Affect Mortality]
- CTRMN042295-2298 [Summary of Meeting on Status of Research]
- CTRMN042299-2304 [Draft of Contract for Inhalation Studies in Syrian Hamsters]
- CTRMN042305-2308 [Comments From Counsel About Contract Form]
- CTRMN042309-2316 [Agreements Between Ctr and Bioresearch Institute and Bioresearch Consultants]
- CTRMN042317-2345 Skin Painting Studies in Syrian Hamsters Skin Painting Techniques and in Vivo Carcinogenesis Bioassays Progress in Experimental Tumor Research, Vol. 26 [St Skin Painting Caused Tumors in Hamsters More Frequently Than in Mice]
- CTRMN042346-2350 Pulmonary Eistopathology of Hamsters Exposed to Smoke [Histopathological Findings of Study of Hamsters Exposed to Cigarette Smoke]
- CTRMN042351-2403 [Expanded Study of Mouse Skin Exposure to Whole Fresh Smoke Condensate Compared to Skin Painting Final Report]
- CTRMN042404-2405 [Ctr Delaying Approval for Continuation of Smoke Inhalation Studies Seeks Guidance in Procuring Funding]
- CTRMN042406-2406 Bio Research Consultants, Inc. Consultants to the Tobacco Industry Since 1959, Is Now Offering A New Technology-- A Fresh Smoke Inhalation Method [Offering Smoke Inhalation Studies to Tobacco Industry]
- CTRMN042407-2422 [Results and Methods of Bioresearch Consultants' Studies Are Property of Ctr Inhalation Studies with Cigarette Smoke]
- CTRMN042423-2423 [Disputes Claim That His Actions Are Breach of Contract]
- CTRMN042424-2424 [Suggests Meeting with Hockett and Jacob Before Presenting Paper]
- CTRMN042425-2425 [Summarizes Conversation Publish Scientific Data But Clarify Source of Interpretations and Ownership of Patents]
- CTRMN042426-2426 [Abandon Bulletin on Inhalation Studies with Cigarette Smoke Delay Involving American Society for Testing Materials One Year]
- CTRMN042427-2427 [Abandon Bulletin on Inhalation Studies with Cigarette Smoke Delay Involving American Society for Testing Materials One Year]
- CTRMN042428-2473 [Manuscript on Strain Differences in the Response of Inbred Syrian Hamsters to Cigarette Smoke Inhalation Submitted for Approval to Publish]
- CTRMN042474-2552 "Final Report on Contract C-191 A Project Entitled "the Determination of the Usefulness of the Syrian Golden Hamster As Model Animal for Inhalation Studies"" [75 Weeks' Exposure to Cigarette Smoke Produced Various Results in Hamsters, Including Macrophages in the Lungs, Increased Heart and Lung Weights, and Decrease in Body Weight]
- CTRMN042553-2553 [Encloses Assignment for Patent No. 3528435 Seeks Direction in Withdrawing Paper at Federation Meeting]
- CTRMN042554-2554 Sugar in Tobacco [Deplores Speculation in Tobacco Controversy Reports on Successful Studies of Smoke Inhalation with Hamsters]
- CTRMN042555A-2555 Fluoride Ion Excretion After Inhalation of Several Fluoroethylene Derivatives [St Exposing Rats to Atmospheres of Fluorinated Ethylene Compounds Increased Urinary Excretion of Fluoride Ions]
- CTRMN042555B-2555 Pulmonary Histopathology of Hamsters Exposed to Smoke [St Exposing Hamsters to Cigarette Smoke Resulted in Effects on Pulmonary System]
- CTRMN042555C-2555 Response of Rats to Pyrolysis Products of Fluorinated Polymers [St Physiological Responses of Rats to Pyrolysis Products Included Diuresis]
- CTRMN042556A-2556 Tumor-Associated Alkyldialacylglycerols (Adag) and Other Lipids in the Thymus During Irradiation-Induced Leukemogenesis Pathology 2202 [St Analysis of Tumor-Associated and Other Lipids in Mice Following Radiation Doses]
- CTRMN042556B-2556 the Endocrine Role of Dietary Lipids in Mammary Tumor Formation Pathology 2203 [St Mice Fed Lipids to Determine Effect on Tumor Development]
- CTRMN042556C-2556 Effects of Altered Dietary Fat Intake on Serum Prolactin Titer Pathology 2204 [St High Fat Diet in Rats Resulted in Increased Serum Prolactin Levels]
- CTRMN042556D-2556 Altered Incorporation of 3h-Thymidine in Hamster Tracheal Epithelium Caused by Respiratory Carcinogens Pathology 2205 [St Hamster Research Suggests That Dna Damaged by Respiratory Carcinogens in Vitro Can Be Repaired]
- CTRMN042556E-2556 Histopathology of Respiratory System of Bio 15.16 Hamsters Chronically Exposed to Cigarette Smoke [St Hamsters Exposed to Smoke Had More Pathological Lesions in Their Larynxes]
- CTRMN042556F-2556 Peritoneal Mesothelioma Pathology 2207 [St Study of Patients with Symptoms of Peritoneal Mesothelioma]
- CTRMN042557-2573 Strain Differences in the Response of Inbred Syrian Hamsters to Cigarette Smoke Inhalation Journal of the National Cancer Institute, Vol. 53, No. 4 [St Smoke Exposure Resulted in Reduced Body Weight, Enlarged Heart and Lungs, Hyperplastic or Neoplastic Changes in the Larynx, and Microinvasive Cancer in Hamsters]
- CTRMN042574-2591 Experimental Lung Cancer Carcinogenesis and Bioassays Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters [St Smoke Inhalation Produced Hyperplastic Changes in Hamster Larynxes and Decreased Body Weight, But Did Not Affect Mortality Strain Differences Were Pronounced]
- CTRMN042592-2599 ""Smokers' Larynx" and Carcinoma of the Larynx in Syrian Hamsters Exposed to Cigarette Smoke" [St Smoke Exposure Resulted in Cancer of the Larynx and Severe Epithelial Changes in Hamsters]
- CTRMN042600-2603 Homotransplantation of Larynxes of Cigarette Smoke-Exposed Syrian Hamsters (38760) Proceedings of the Society for Experimental Biology and Medicine, Vol. 149 [St Sections of Hamster Larynxes Were Transplanted Into Cheek Pouches of Other Hamsters Hyperplasia Caused by Cigarette Smoke Persisted Up to One Year Without Further Exposure to Smoke]
- CTRMN042604-2626 Differentiations in Cigarettes Off Materials Other Than Tobacco Medicine Et Hygiene, No. 1216 [St Smoke From Cigarettes Made From Cytrel Contains Less Tar Than Tobacco Smoke and No Nicotine]
- CTRMN042627-2670 Advances in Modern Toxicology New Concepts in Safety Evaluation [St Syrian Hamsters Are A Valuable Option for Animal Experiments]
- CTRMN042671A-2673 Detection of Chemical Mutagens Using Concentration Gradient Plates: Observations on Results with 414 Compounds Toxicology and Applied Pharmacology, Vol. 45 [St Discovery of Chemical Mutagens]
- CTRMN042671B-2673 Dominant Lethal Studies in Rats of Five Hair Die Components: 2 Nitro P Phenylenediamine, 4 Nitro O Phenylenediamine, M Phenylenediamine, 2.4 Diaminoanisoic Sulfate, and 2.5 Diaminoanisoic Sulfate Toxicology and Applied Pharmacology, No. 45 [St Weak Lethality Results From Exposure of Rats to Hair Die Components]
- CTRMN042671C-2673 Motor Oil Antagonism of the Effects of So2 on Pulmonary Function in the Guinea Pig Toxicology and Applied Pharmacology No. 45 [St Motor Oils Reduced Irritancy of So2]
- CTRMN042671D-2673 Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters. I: Methods and Dosimetry Toxicology and Applied Pharmacology Vol. 45 [St Hamsters Exposed to Tobacco and Cytrel Cigarette Smoke and Results Noted]
- CTRMN042671E-2673 Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters. II: Histopathological Lesions in the Respiratory Tract Toxicology and Applied Pharmacology, Vol. 45 [St Tobacco Smoke Resulted in Larynx Problems Including Invasive Carcinoma Cytrel Smoke Resulted in Much Less Damage]
- CTRMN042671F-2673 Pulmonary Pathology in Rats Exposed to Marijuana Smoke for One Year Toxicology and Applied Pharmacology, Vol. 45 [St Rats Exposed to Marijuana Smoke Developed Focal Pneumonitis in Proportion to Dosage]
- CTRMN042671G-2673 Studies on the Pulmonary Uptake of Paraquat Toxicology and Applied Pharmacology, Vol. 45 [St Distribution of Paraquat in Rat Lungs Was Not Uniform]
- CTRMN042674-2749 Chemical Carcinogenesis in Syrian Hamsters: A Review (Through 1976) Progress in Experimental Tumor Research, Vol. 23 [St Hamsters Are Useful Experimental Animals for A Variety of Carcinogenesis Studies]
- CTRMN042750-2764 Cigarette Smoke Inhalation Studies in Inbred Syrian Golden Hamsters Journal of the National Cancer Institute, Vol. 65, No. 3 [St Cancer Was Developed in Hamsters Exposed to Tobacco Smoke Cancer Rates Were Proportional to Smoke Concentration and Tobacco/Cytrel Ratio in Cigarettes]
- CTRMN042765-2769 Cigarette Smoke-Induced Cancer of the Larynx in Hamsters (Cinch): A Method to Assay the Carcinogenicity of Cigarette Smoke Progress in Experimental Tumor Research, Vol. 24 [St Hamster Experiments Are Valid Assay of Tobacco Smoke Carcinogenesis]
- CTRMN042770-2772 in Vivo Carcinogenesis Testing Toxicologic Pathology, Vol. 7, No. 1 [St Smoke-Inhalation Experiments with Hamsters Are Quantitative Assay Method for Relative Carcinogenicity of Cigarette Smokes]
- CTRMN042773-2782 Carcinogenesis in the Upper Aerodigestive Tract [St Carcinogens Such As Tobacco Applied to Mucous Membranes Result in Multiple Tumors Which Are Difficult to Treat]
- CTRMN042783-2787 Subchronic Cigarette Smoke Inhalation Studies in Inbred Syrian Golden Hamsters That Develop Laryngeal Carcinoma Upon Chronic Exposure Journal of the National Cancer Institute, Vol 71, No. 3 [St Smoke From All-Tobacco Cigarettes Caused More Respiratory and Larynx Problems Than From Cellulose-Derived Tobacco Supplement Cigarettes]
- CTRMN042788-2796 A New First-Generation Hybrid Syrian Hamster, Bio F1d Alexander for in Vivo Carcinogenesis Bioassay, As A Third Species or to Replace the Mouse Surv. Synth. Path. Res., Vol. 7 [St This Strain of Hamster Is Perhaps the Best Suited for Cancer Experiments]
- CTRMN042797-2800 [Comments on Slides From Effects of Smoke on Upper Respiratory Tract]
- CTRMN042801-2802 [Conditions for Approval of Publishing Findings]
- CTRMN042803-2810 [Disputing Ctr's Decision to Discontinue Research Chronology of Research-Related Events]
- Author
- Homburger, F., Bioresearch Consultants
- Recipient
- Gori, G.B.
- Type
- LETTER
- Box
- 267
- UCSF Legacy ID
- omt30a00
Document Images
THE COt\CLL FOR TOBACCO RCSE.kRCEI-I:.S. A.. I-,,;C.
110 E_%ST S0TV STRF.ri'
\EtN TORK. N. i. 10082
?eb:uLrf 26, 2973
Freddy Hoxbu-ye_, M.D.
President and Diector
Bio-P.esearch Consultants, Inc.
9 Commercizl Avenue
CrsbridQe, 14assa_iuset.s 02141
Dear Fredcf :
I L:.dersta.nd you have been adrised we have 3ee n fu--aished cozies of
yous letter to N_. Edwin v. JLc^ J- dated Feb:uL:y 7, 13Z3 and of your b=ciure
entitle3"Iahalat:an Studias aithCicarette S.:a:ce - A Technical Bulletin on
Me:r.o3s Used :.y Bio-Research Consultants, Inc." Also L a-m inforad that Dr.
Gard.ier in his conversation with you ir. New 8aven on 22, 1973, discussed
with you the r.ecessitY of co-me'_e:i.^.c the work called f:= =nde= o;t_: cozt_->-ct "The
Deter=ilatior: of the Usef_lr.ess of t.`.e Golden Syrian E-. :er as Y.o<'_el A.nL-al for
Inhalation St_dies" before a.nv definitive conclusions :a-. be .ade. Such
conclusions L_:e necessar-., before z-i_i de=isioz can be r_de as to f,_-t::e: expe=i-
mentL:ion relating to ci;=ette s-r.:<e e:c=csu:e of ha-sers.
In _:ou= letter to N.r. jacob and in yo'_ ^ecacLl b_lle='-n you
O'. _.lOc:Ce : ...._ ~_c /__-_..3 of Ol_ c0..t:-..t t~t VO'- reS..i6Q Ls Sollcws 7
'A11 data o'ocainad an_ all in:ar.=ias, davelct_ent.3`indi-,s
or -:s=ov_=-__ w..-.: e: or r.ot p==-..tib:_ -e =y _:o-: ese=c:: Cons::I_a:.ts,
Ir.c. -- the cou=sa of, or as a result of, .:c..-+c done under t..'-s a;=-=-,t
s^a11 =a t^e so:e andex:lus:*re *rn_ ar=:: of :he Co_Zcil tc= _cbac=o
Resear:a - U.S.?.. Bic-Researc.i Consultants, In:. agrees to 'keep sac:at
- conn-=tic::
-.o:led;eor data obtained ..
a:.d cc..:'-centia- any ;c
it: c:rs a res_lt c', work done ur.'-e: t~,~s a7xe=ent and fu=tier a;rees
not to use such S:4fo:-3aOF. :CT itse!f or :Z' O--IeTs e±t:.a: -iraC- := or
`
or disclose -' to -1./ t1i. CL='`J- C? _.._ Council for
?.esea_c : - U.=.... wi _.oLt :.._Cou_.ci:'s prior v=_---.n ap:=c:L1.
"All a:uipment, doc'--aents, books, :accrts, notes or other
aateria.is or data furnished by or on beial' af ^he Council for Tobacco
Research - U.S.A. in connectien with work cole c:der this e=reer.ent shall
at all tiwes be the or==e_t: of T:e Cou_-lcil'or Tocacco ?.esea::i
and shall bo ra:_ned : Bio-:esearc:n Ccns:.:eans, Inc: to .:.a res_a:_ive
owne_ as designated by The Co-*ncil for ToSa=o ?.esearch - U.S.A. at the
ter-_ination c° this a;re=ent, or at any tim t=s= The Ccu^.c:_ for =cbLccc
Rese3rG'1 - U.S.A. mav :ecuest."
CTR CO~~4TC~RCT~ 0057716
11225457
C" 1u R 1-1 11-151 0 41 22-22. 11
/
Tiai: CoL.crz, FoR ToB.%.cco RESCarcu -U.S.A., I.c.
Freddy Hcoburger, M.D. - 2 - PeSr.:a_-y 26, 1973
Consent has not been given by us to yous disclasure of infor-zation,
:a3owledye or data o~tair.ed in connectica with or as a_esult of work dor.e under
our agreen,ent nor has consent been given to use such information. As you knc,+,
the work to be perforred under t.he contract was in the r.zture of a feasibility
study. To date, I am informed, the results are incocslete and inconclusive.
Your Technical Bulletin refers to the Waltoa -%5orrissey saoie e:cposure
maahine ycu have been using and states aaong other things (page 2) that this is
your aacisine. The aachines you have been using are our oroperty and are su:ject
to the provisions of the second paragraph csuoted ebove frea our contract. As you
kaa.+, we z~so own the catent on the m:.chine. The eachines used by ycu are not
the kind to be used in future work, there having been scztstantial i-.roverae^ts
since the model used by vou xrs const^:cted.
Ov-- relations with you and yo;ir coonanies `3<rocgh t.e years have been
cor: ial a:.d we dislike iavi.n.g to write you in the vei- of this letter. Hoaeve_,
we nust insist that ar.: party entering in a contract with us acn^.e_e to the te=os
of that contract.
Sincere?v.
W. T. Fioy
Exec:tive vice _resident
cc. _c+ir. :.
CTR caNTRRCTS1 005717'
11225458
C ~~ ~~ 1-1 ~~ ~~ ~) 4 ~ ~~ ~ ~
A?ri1 16, 1974
Peter Bernfeld, Ph.D.
Director of Research
Bio-Research Consultants, I::c.
9 Co®ercial Avenue
Cambridge, Massachusetts 02141
Dear Doctor Bernfeld:
In response to your letter of Aoril 3rd, concerning the
application for a contract to test a precondensed s.oke concentra_e
and an instant s-mo}:e condensate, I car. now state that it will be
impossible to fund this contract at this time. The unusually lasye
nwnber of grants and co^-ra--ts that have becose available for
cors ideration by the Scier.ti'ic Advisory 3oard has :.a'_e it necesaanr
to establish priorities. The very extensive worK that has been
supported by other agencies using the skin apolicaticn rethods `as
r,.oved the percutaneous applicrtior. of tars and fractior.s to a lcver
priority.
Iwss impressed by your detaile3 report of the caper'_ner.t
that was eecn, leted 1rst 'all and do hoee to receive soon a copy =_
the «enusc=iot that will be submitted for Fu:hlicatic n. It aiq` _ be
advsatagecis i° it a^+ea_e:'l befcre the large studies dor,e b? the :. ._.
were reYorte3. I have iPar3 that they are noc+ bein" s~~^arized. -
agree with Lie sta`e-ent ,.iz` you cuoted Cro:r. the N.nu_1 Rc?o=: :: The
Council. Cr. :!oayet' anc' I have talked about the nee'_ ef a cor.:i^s=o^!
experi:nent :+u= it cannot be _°uu:dn: at this tine.
Sincerely yours,
ailliaa U. Gardr:er, Ph.D.
Scientific Director
t4UG : ek
CTR CCNTRRCTS 4Q5519
11225260
CTR NN 04-22-1-3
