Council for Tobacco Research
Deposition of Freddy Homburger, M.D. [Deposition of Homburger in the Matter of Broin]
Fields
- Master ID
- Ctrmn00041967-2810
Related Documents:- CTRMN042115-2200 Deposition of Freddy Homburger, M.D. [Deposition of Homburger in the Matter of Broin]
- CTRMN042201-2213 Chronology of Events [Letters and Chronology Outline Dispute Over Publishing Research on Cigarette Smoke and Hamsters]
- CTRMN042214-2228 Inhalation Carcinogenesis Experimental Investigations on the Effect of Cigarette Smoke Inhalation on Small Laboratory Animals [St Effects of Long-Term Exposure to Tobacco Smoke on Small Animals]
- CTRMN042229-2248 [Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters]
- CTRMN042249-2251 [Comments and Suggestions on Study Titled Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters]
- CTRMN042252-2269 Strain Differences in the Response of Inbred Syrian Hamsters to Cigarette Smoke Inhalation Journal of the National Cancer Institute, Vol. 53 [St Cigarette Smoke Caused More Cancer in One Strain of Hamsters Than Another]
- CTRMN042270-2294 Progress Report for the Current Contract Period and Renewal Application (with Budget) of the Project Entitled the Determination of the Usefulness of the Golden Syrian Hamster As Model Animal for Inhalation Studies [Cigarette Smoke Inhalation Caused Macrophages in Some Hamsters' Lungs and Reduced Weight Gain But Did Not Affect Mortality]
- CTRMN042295-2298 [Summary of Meeting on Status of Research]
- CTRMN042299-2304 [Draft of Contract for Inhalation Studies in Syrian Hamsters]
- CTRMN042305-2308 [Comments From Counsel About Contract Form]
- CTRMN042309-2316 [Agreements Between Ctr and Bioresearch Institute and Bioresearch Consultants]
- CTRMN042317-2345 Skin Painting Studies in Syrian Hamsters Skin Painting Techniques and in Vivo Carcinogenesis Bioassays Progress in Experimental Tumor Research, Vol. 26 [St Skin Painting Caused Tumors in Hamsters More Frequently Than in Mice]
- CTRMN042346-2350 Pulmonary Eistopathology of Hamsters Exposed to Smoke [Histopathological Findings of Study of Hamsters Exposed to Cigarette Smoke]
- CTRMN042351-2403 [Expanded Study of Mouse Skin Exposure to Whole Fresh Smoke Condensate Compared to Skin Painting Final Report]
- CTRMN042404-2405 [Ctr Delaying Approval for Continuation of Smoke Inhalation Studies Seeks Guidance in Procuring Funding]
- CTRMN042406-2406 Bio Research Consultants, Inc. Consultants to the Tobacco Industry Since 1959, Is Now Offering A New Technology-- A Fresh Smoke Inhalation Method [Offering Smoke Inhalation Studies to Tobacco Industry]
- CTRMN042407-2422 [Results and Methods of Bioresearch Consultants' Studies Are Property of Ctr Inhalation Studies with Cigarette Smoke]
- CTRMN042423-2423 [Disputes Claim That His Actions Are Breach of Contract]
- CTRMN042424-2424 [Suggests Meeting with Hockett and Jacob Before Presenting Paper]
- CTRMN042425-2425 [Summarizes Conversation Publish Scientific Data But Clarify Source of Interpretations and Ownership of Patents]
- CTRMN042426-2426 [Abandon Bulletin on Inhalation Studies with Cigarette Smoke Delay Involving American Society for Testing Materials One Year]
- CTRMN042427-2427 [Abandon Bulletin on Inhalation Studies with Cigarette Smoke Delay Involving American Society for Testing Materials One Year]
- CTRMN042428-2473 [Manuscript on Strain Differences in the Response of Inbred Syrian Hamsters to Cigarette Smoke Inhalation Submitted for Approval to Publish]
- CTRMN042474-2552 "Final Report on Contract C-191 A Project Entitled "the Determination of the Usefulness of the Syrian Golden Hamster As Model Animal for Inhalation Studies"" [75 Weeks' Exposure to Cigarette Smoke Produced Various Results in Hamsters, Including Macrophages in the Lungs, Increased Heart and Lung Weights, and Decrease in Body Weight]
- CTRMN042553-2553 [Encloses Assignment for Patent No. 3528435 Seeks Direction in Withdrawing Paper at Federation Meeting]
- CTRMN042554-2554 Sugar in Tobacco [Deplores Speculation in Tobacco Controversy Reports on Successful Studies of Smoke Inhalation with Hamsters]
- CTRMN042555A-2555 Fluoride Ion Excretion After Inhalation of Several Fluoroethylene Derivatives [St Exposing Rats to Atmospheres of Fluorinated Ethylene Compounds Increased Urinary Excretion of Fluoride Ions]
- CTRMN042555B-2555 Pulmonary Histopathology of Hamsters Exposed to Smoke [St Exposing Hamsters to Cigarette Smoke Resulted in Effects on Pulmonary System]
- CTRMN042555C-2555 Response of Rats to Pyrolysis Products of Fluorinated Polymers [St Physiological Responses of Rats to Pyrolysis Products Included Diuresis]
- CTRMN042556A-2556 Tumor-Associated Alkyldialacylglycerols (Adag) and Other Lipids in the Thymus During Irradiation-Induced Leukemogenesis Pathology 2202 [St Analysis of Tumor-Associated and Other Lipids in Mice Following Radiation Doses]
- CTRMN042556B-2556 the Endocrine Role of Dietary Lipids in Mammary Tumor Formation Pathology 2203 [St Mice Fed Lipids to Determine Effect on Tumor Development]
- CTRMN042556C-2556 Effects of Altered Dietary Fat Intake on Serum Prolactin Titer Pathology 2204 [St High Fat Diet in Rats Resulted in Increased Serum Prolactin Levels]
- CTRMN042556D-2556 Altered Incorporation of 3h-Thymidine in Hamster Tracheal Epithelium Caused by Respiratory Carcinogens Pathology 2205 [St Hamster Research Suggests That Dna Damaged by Respiratory Carcinogens in Vitro Can Be Repaired]
- CTRMN042556E-2556 Histopathology of Respiratory System of Bio 15.16 Hamsters Chronically Exposed to Cigarette Smoke [St Hamsters Exposed to Smoke Had More Pathological Lesions in Their Larynxes]
- CTRMN042556F-2556 Peritoneal Mesothelioma Pathology 2207 [St Study of Patients with Symptoms of Peritoneal Mesothelioma]
- CTRMN042557-2573 Strain Differences in the Response of Inbred Syrian Hamsters to Cigarette Smoke Inhalation Journal of the National Cancer Institute, Vol. 53, No. 4 [St Smoke Exposure Resulted in Reduced Body Weight, Enlarged Heart and Lungs, Hyperplastic or Neoplastic Changes in the Larynx, and Microinvasive Cancer in Hamsters]
- CTRMN042574-2591 Experimental Lung Cancer Carcinogenesis and Bioassays Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters [St Smoke Inhalation Produced Hyperplastic Changes in Hamster Larynxes and Decreased Body Weight, But Did Not Affect Mortality Strain Differences Were Pronounced]
- CTRMN042592-2599 ""Smokers' Larynx" and Carcinoma of the Larynx in Syrian Hamsters Exposed to Cigarette Smoke" [St Smoke Exposure Resulted in Cancer of the Larynx and Severe Epithelial Changes in Hamsters]
- CTRMN042600-2603 Homotransplantation of Larynxes of Cigarette Smoke-Exposed Syrian Hamsters (38760) Proceedings of the Society for Experimental Biology and Medicine, Vol. 149 [St Sections of Hamster Larynxes Were Transplanted Into Cheek Pouches of Other Hamsters Hyperplasia Caused by Cigarette Smoke Persisted Up to One Year Without Further Exposure to Smoke]
- CTRMN042604-2626 Differentiations in Cigarettes Off Materials Other Than Tobacco Medicine Et Hygiene, No. 1216 [St Smoke From Cigarettes Made From Cytrel Contains Less Tar Than Tobacco Smoke and No Nicotine]
- CTRMN042627-2670 Advances in Modern Toxicology New Concepts in Safety Evaluation [St Syrian Hamsters Are A Valuable Option for Animal Experiments]
- CTRMN042671A-2673 Detection of Chemical Mutagens Using Concentration Gradient Plates: Observations on Results with 414 Compounds Toxicology and Applied Pharmacology, Vol. 45 [St Discovery of Chemical Mutagens]
- CTRMN042671B-2673 Dominant Lethal Studies in Rats of Five Hair Die Components: 2 Nitro P Phenylenediamine, 4 Nitro O Phenylenediamine, M Phenylenediamine, 2.4 Diaminoanisoic Sulfate, and 2.5 Diaminoanisoic Sulfate Toxicology and Applied Pharmacology, No. 45 [St Weak Lethality Results From Exposure of Rats to Hair Die Components]
- CTRMN042671C-2673 Motor Oil Antagonism of the Effects of So2 on Pulmonary Function in the Guinea Pig Toxicology and Applied Pharmacology No. 45 [St Motor Oils Reduced Irritancy of So2]
- CTRMN042671D-2673 Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters. I: Methods and Dosimetry Toxicology and Applied Pharmacology Vol. 45 [St Hamsters Exposed to Tobacco and Cytrel Cigarette Smoke and Results Noted]
- CTRMN042671E-2673 Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters. II: Histopathological Lesions in the Respiratory Tract Toxicology and Applied Pharmacology, Vol. 45 [St Tobacco Smoke Resulted in Larynx Problems Including Invasive Carcinoma Cytrel Smoke Resulted in Much Less Damage]
- CTRMN042671F-2673 Pulmonary Pathology in Rats Exposed to Marijuana Smoke for One Year Toxicology and Applied Pharmacology, Vol. 45 [St Rats Exposed to Marijuana Smoke Developed Focal Pneumonitis in Proportion to Dosage]
- CTRMN042671G-2673 Studies on the Pulmonary Uptake of Paraquat Toxicology and Applied Pharmacology, Vol. 45 [St Distribution of Paraquat in Rat Lungs Was Not Uniform]
- CTRMN042674-2749 Chemical Carcinogenesis in Syrian Hamsters: A Review (Through 1976) Progress in Experimental Tumor Research, Vol. 23 [St Hamsters Are Useful Experimental Animals for A Variety of Carcinogenesis Studies]
- CTRMN042750-2764 Cigarette Smoke Inhalation Studies in Inbred Syrian Golden Hamsters Journal of the National Cancer Institute, Vol. 65, No. 3 [St Cancer Was Developed in Hamsters Exposed to Tobacco Smoke Cancer Rates Were Proportional to Smoke Concentration and Tobacco/Cytrel Ratio in Cigarettes]
- CTRMN042765-2769 Cigarette Smoke-Induced Cancer of the Larynx in Hamsters (Cinch): A Method to Assay the Carcinogenicity of Cigarette Smoke Progress in Experimental Tumor Research, Vol. 24 [St Hamster Experiments Are Valid Assay of Tobacco Smoke Carcinogenesis]
- CTRMN042770-2772 in Vivo Carcinogenesis Testing Toxicologic Pathology, Vol. 7, No. 1 [St Smoke-Inhalation Experiments with Hamsters Are Quantitative Assay Method for Relative Carcinogenicity of Cigarette Smokes]
- CTRMN042773-2782 Carcinogenesis in the Upper Aerodigestive Tract [St Carcinogens Such As Tobacco Applied to Mucous Membranes Result in Multiple Tumors Which Are Difficult to Treat]
- CTRMN042783-2787 Subchronic Cigarette Smoke Inhalation Studies in Inbred Syrian Golden Hamsters That Develop Laryngeal Carcinoma Upon Chronic Exposure Journal of the National Cancer Institute, Vol 71, No. 3 [St Smoke From All-Tobacco Cigarettes Caused More Respiratory and Larynx Problems Than From Cellulose-Derived Tobacco Supplement Cigarettes]
- CTRMN042788-2796 A New First-Generation Hybrid Syrian Hamster, Bio F1d Alexander for in Vivo Carcinogenesis Bioassay, As A Third Species or to Replace the Mouse Surv. Synth. Path. Res., Vol. 7 [St This Strain of Hamster Is Perhaps the Best Suited for Cancer Experiments]
- CTRMN042797-2800 [Comments on Slides From Effects of Smoke on Upper Respiratory Tract]
- CTRMN042801-2802 [Conditions for Approval of Publishing Findings]
- CTRMN042803-2810 [Disputing Ctr's Decision to Discontinue Research Chronology of Research-Related Events]
- Author
- Bohan, A.H.
- Homburger, F.
- Depository Date
- 08 Sep 1997
- Box
- 267
- Type
- TRANSCRIPT
- UCSF Legacy ID
- mmt30a00
Document Images
1
Volume I
Pages 1 to 147
Exhibits 1 - 12
IN THE CIRCUIT COURT OF THE 11TH JUDICIAL CIRCUIT
IN AND FOR DADE COUNTY, FLORIDA
GENERAL JURISDICTION DIVISION
-x
NORMA R. BROIN, et al.,
Plaintiffs,
`I s .
PHILIP MORRIS COMPANIES, INC.,
et al.,
Def endants .
: Case No.
: 91-49738 CA22
-x
DEPOSITION OF FREDDY HOMBURGER, M.D., a
witness called on behalf of the Defendants Philip
Morris Incorporated, Philip Morris Products, Inc.,
and Lorillard, taken pursuant to the Florida Rules
of Civil Procedure, before Anne H. Bohan, Registered
Professional Reporter and Notary Public in and for
the Commonwealth of Massachusetts, at the Offices of
Goodwin, Procter & Hoar, 53 State Street, Exchange
Place, Boston, Massachusetts, on Tuesday, May 27,
1997, commencing at 11:10 a.m.
PRESENT:
Stanley M. Rosenblatt, Esq.
(by Mary Margaret Schneider, Esq.)
66 West Flagler Street, Miami, FL 33130,
for the Plaintiffs.
Shook, Hardy & Bacon LLP (by Billy R. Randles,
Esq. and Robert E. Northrip, Esq.)
One Kansas City Place, 1200 Main Street,
Kansas City, MO 64105-2118,
for the Defendants Philip Morris
Incorporated, Philip Morris
Products, Inc., and Lorillard.
DORIS O. WONG ASSOCIATES
CTR f f f'"f S.,,f `Y' .L 96~i' j

2
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
PRESENT, Continued:
Jones, Day, Reavis & Pogue
(by David B. Alden, Esq.)
North Point, 901 Lakeside Avenue,
Cleveland, OH 44114,
for the Defendant R.J. Reynolds
Tobacco Company.
Debevoise & Plimpton (by Steven Klugman, Esq.
and Peter C. Johnson, Esq.)
875 Third Avenue, New York, NY 10022,
for The Council of Tobacco
Research-U.S.A., Inc.
ALSO PRESENT: Theresa Becker
Vicki B. Thompson
DORIS 0. WONG ASSOCIATES
urtz HN 0419~'~ 8

Q;
,::~qttozncys t=
CTR MN 041969

3
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
I N D E X
WITNESS: DIRECT CROSS REDIRECT RECROSS
Freddy Homburger, M.D.
(By Mr. Randles) 5
(By Mr. Klugman) 122,143
(By Mr. Alden) 141
t t *
E X H I B I T E
EX. N0. PAGE
1October 1, 1968, letter to
Robert C. Hockett from Freddy
Homburger, M.D., Nos.
TEH13393-95 81
2 Page 560 from the March 10, 1973,
The Lancet, including letter from
Freddy Homburger entitled "Sugar
in Tobacco," No. TEH14906 90
3 Technology and Applied
Pharmacology article entitled
"Abstracts of Papers for the
Twelfth Annual Meeting of the
Society of Toxicology" 90
4 One page from March 1974
Proceedings of the Federation
of American Society for
Experimental Biology" 91
5 Multi-page document entitled
"Strain Differences in the
Response of Inbred Syrian
Hamsters to Cigarette Smoke
Inhalation" 92
DORIS 0. WONG ASSOCIATES
CT R N N 0 4 19 7" 0

4
1
2
3
4
5
6
7
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
EXHIBITS, Continued
EX. NO. PAGE
6 Multi-page document entitled
"Experimental Lung Cancer,
Carcinogenesis and Bioassays,"
June 23-26, 1974 93
7 Letter to Dr. William Gardner
from Freddy Homburger with
attachment "Chronology of
Events," Nos. 005639-5646 97
8 Letter dated June 19, 1970
to W.T. Hoyt from Freddy
Homburger with attachments,
Nos. TEH14835-42 99
9 April 22, 1974, confidential
memorandum to Henry-Tom
from L.S.Z., Nos. 19604-05 111
10 Multi-page Bio-Research
Consultants, Final Report on
Contract C-191 dated September
1973 119
11 March 28, 1974, letter
to Robert C. Hockett from
Freddy Homburger with
attachment, Nos. TEH14986-15031 119
12 May 27, 1997, letter, by hand,
to Mary Margaret Schneider from
Billy R. Randles 145
DORIS 0. WONGASSOCIATES
E.~ ~V R H N 0 4 1 RE 'i"" I

5
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
P R 0 C E E D I N G S
FREDDY HOMBURGER M.D.
a witness called for examination by counsel for the
Defendants Philip Morris Incorporated, Philip Morris
Products, Inc., and Lorillard, being first duly
sworn, was examined and testified as follows:
DIRECT EXAMINATION
BY MR. RANDLES:
Q. Dr. Homburger, we met briefly before. My
name is Billy Randles. I'm a lawyer with the law
firm of Shook, Hardy & Bacon. I represent Philip
Morris and Lorillard Tobacco Companies in this
case.
Would you state your full name for the
record, please.
A. My name is Freddy, F-r-e-d-d-y, Homburger,
H-o-m-b-u-r-g-e-r.
Q. What is your age, Dr. Homburger?
A. 81 going on 82. I'm born February 8,
1916. Seems impossible.
Q. We should all look so good at 81.
How is your health, Doctor?
A. Well, you want a list of my ills? I have
Parkinson's disease. I have gout. I have
DORIS 0. WONG ASSOCIATES
CTR VIN 04197,','

6
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
hypertension. I have two artificial knees. I have
two artificial eye lenses. And apart from that --
my prostate we won't discuss. Apart from that I'm
all right.
Q. Are you on any medication today that would
impair your ability to answer my questions?
A. No, not at all. I am taking Synemet, which
is a drug that controls the Parkinson's, and I take
some vitamin C, some aspirin, but no narcotics or
pain-relieving medication.
Q. I mean this very respectfully. How would
you describe your memory?
A. My memory is not as good as it was 20 years
ago, but it's still pretty good.
Q. Good. If I ask you any questions today
that you don't understand, I'd like for you to stop
me and I will rephrase them.
A. I will do that.
Q. And if I ask you any questions that you
don't have a memory of, please just tell me that.
All right?
A. I will.
Q. As we go on today, any time you want to
take a break, you let me know and that will be
DORIS O. WONG ASSOCIATES
~ F~ I-I~~ ~~4, 1~~ " °~3

7
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
fine. If you want anything to drink, let me know.
And if you need to get up and stretch or anything
like that, that would be fine. You don't need to
ask, just do that.
A. I understand.
Q. All right. I've noticed you're already
very good at this, but I'll just mention this. In
deposition this lady is taking down everything we
say, so we need to be careful not to talk over each
other, and I notice you're already very good at
that. If I do that to you, I apologize and I will
stop.
Have you ever had your deposition taken
before?
A. Yes.
Q. Do you recall how many times?
A. No. Only once, and I testified once in
court.
Q. Do you remember the case name that you
testified in, in the deposition first?
A. The first deposition was taken in the case
of my wife and myself against Merrill Lynch many
years ago.
Q. And that was regarding investments or
DORIS 0. WONG ASSOCIATES
CTR IIN 041~3~i"4,

8
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
financial affairs?
A. That was regarding their negligence with
one of our investments. And the second time, the
only time I testified in court, was the Cipollone
case in New Jersey, and I don't remember the exact
date, but I suppose everybody does.
Q. What year was the Merrill Lynch case?
A. Oh, it was long ago. We were then living
in New York, and it was 1944 or '45.
Q. When were you first contacted regarding the
Broin case?
A. Excuse me. Regarding?
Q. The Broin case, the case we're here for
today, the flight attendant class action.
A. That was only maybe a couple of weeks ago I
got a telephone call.
Q. Do you recall who called you?
A. I don't recall the name, but it was a woman
lawyer in Mr. Rosenblatt's firm, not Mrs. Schneider.
Q. What did the lady tell you about the case
or why she was calling?
A. At that point she didn't tell me anything
practically about the case. She just asked me
whether I could possibly be a witness in a case that
DORIS O. WONG ASSOCIATES
Cr T R V1 N ~'.~4 1 STIP"E.~

9
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
involved some secondhand smoke. And then I got more
calls later on from the same person, and it was
explained to me more or less what the case was
about.
Finally, it was on Friday last week, or was
it -- it was maybe yesterday that Mr. Rosenblatt
himself called and explained to me what this case
was all about.
Q. What did he tell you the case was about?
A. He told me that it was a case of airplane
attendants on the liability of the cigarette
companies in regard to secondhand smoke effects'. I
told him that my expertise did not extend to
secondhand smoke, and so he explained to me that it
was a question of testifying as to the treatment I
had received from the Council for Tobacco Research'
when it came to publishing facts which the cigarette
companies did not like. That was about the gist of
our conversation.
Q. Were those his words or your words?
A. These are basically my words. I really
wouldn't recall his specific words; it was a long
conversation and largely one-sided. I listened and
he talked.
DORIS 0. WONGASSOCIATES
C"T~' t-IN ~°'.~ 419" G)
