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I . C,GItF''hD'J~FLfIAL ~ C 40 . Itr. 0. P. V4Czmaa C'ONF_iDENTIAL b4r. J. 7. Cull=, 3rd ltr. Deorie Vedssyaa J1aly 20, 1956 )!r. We H. BatOher 74 N. Du312ia &m nex Droduct Bdvantaaea for ventilated oigarettee have recently been discorvvred in this laboratory. These lead to the poasibility of an aggroeBive oountor-ettaak oon the haalth oLsarsee U%ich have boea rasde agalnat oigarette ezaoking. You ue tamiliar tdth the advantages toiZaerly determinad for ventilatod oi6arettee euch as dooraased ecDOka solids and fla S.~nc~re~ae~oetl~n cost, easy draw a,nvoe~ abilit bliev~y o~t pro~ ~ble olaSns becauso of visible o2arsge in the papar. The new advmtagea te a proved dearesse in carbon monoxide and carbon clivxlde plus an incraase 3.n oz,vgan content of the emtte, and eubJectively docreaoed irritation by the amo3oe. tboroased cazton =%oxide and niootine are related to deoreaaed ham to the oirculatoay a7stas as a re$ult of emaking. .'. Zbcroasod ~oka solids give the advantage of tiltor oisarettee in reduction of axposure to awl uodosirod oPtect of molcs on Purthor tiian this, however decreasod carbon monoxido indicates swre oaxplete coasbvation of the oigarotte, and would be e.-31_Pectod to result in destruction of part of axV undesirable t~ydrocarbone thich ><aigtit be present in smoke, specifically polynuolear hyrdraaarbsms. ?n autonobilo eshaust, tor instance, engine E3ett1T1g8 Tt'llch give mini_ rniri CgrboA IDoilo.Xide also give ninlrxtiua t70.rocarUma ouch as { 2acraesed oz7gea contmt, accordina to the Warburg theory, raoane lcisu ahe=e of depriving celie of oxygen and of starting a possible chain ot events 18ading to the tomation of a~., . oeincer aell. Carbon dicc.tde, e.lthough ncan-touio in emall anowlta, is a respiratory aontaamlx3ant, and its rrduction in araolce is deeirablor Deoreeaod irritation is desirable not only from the subjective . viewpoint but also as a partial olimination ot a potcantial 1-+ cancer 1.uaxard. Irritation of lung cilia can deoreasa or 0n • ehsziaato the bbdlity cS oilia to renov~o foreign eubetanoee ~ vuch ae dayositod eznolse solids trom the lung. E[treme ' ir: Statlon my '.lso loe,d to dar~e to 1ung cc~ller ttith G1 iricreaaod aRmoe of mtiaossaitil attack by tor+eigr~ substances ~j ;:% n i.n the lurtig. ~ N 0 :.~_. O .~ PLAINTI-F S P V. - - lg~ EXHIBIT ; >~c~~A CTR MN 02B4'76

... I TAL OPIFZDFNI' ~, ,C1, ..r ~ rc. 0. P. 14+c~ C Kr. J. Y. Aalltasn, 3rd ` . Prr. Qeorge Oleisasssn .,~.. i pbr. M. Q. Hatcher . ''ONEID ~ ENTIAL, -2- .4 JU.17 20, 1956 As 'you knov, X have discussed xith Dr. Paul ZCotin and hie aasooiatos at the USC Hodiaal School the posaibility of their detemining in the laboretory by ohemical and biological meana Vhether My of the above indi.oated radvantagos of o=tila- ted oUarettes ase provable. Dr. 2Cotin feels that there is a good chance that these proportion trill be demoziatzable and has submitted a reaoarch protocol and a budget of i30,130 for one yoar's work, tfiich should be anple time for carrying out the necesuazy experimente. Iiia grovp is capable and .. interosted, and the fwnds needed are modest for thia type of Mrizt. to M use of the data Sn pramotion or advertising. I tioul.d not tosnt to trust a ccr.raeroial laboratory with this job, altriouah if Kotin's results are favorable we nigbt want a camerol.a3 laboratory to ropeat the aork if txo should tPant Results of Xotin'swork would presumhly be publiahed, since that ie acadeaic p.actioe,c Koaever, the oi9arettes usod tauld be identifiod by a oode lotter only. 1lse hazards of publlca- ticn night be a statament that certain undesirable conatituents and pznperties such as beasz,pyrarw, toxio materials and izrrri tants ara present ln cigarette scnoicea Pbst of such infozmatioa is alroadY available in the literatuz+e, e,zsd 2totin's groV bas etrong Sadication that emoks contains benzpyro,ze, Thin work waa done under a TTRC grant and will presuably be publisbed. . . . :,..;., . , . It rxould be a substantial advantage to have this tark done under Sotin's direotion, although he has given acme Sndication that he my leave USC within a y" Even if succeaaful, St is probable that v+entilatod cigarettes would g:.ve only a partial reduction in uaidesirable proportiea of amoke a Bolleve•r, I fQel that it ii 3aportatlt to 3Gr1o1/,thia, so that w can progro s s further in the ttitture t It is not clear to me hox wo might use any teotmical data ahoxing health advantages of ventilated ci~rettes in advertising and prcaotion, b~it again I fee2. that the data ahauld bo obtainad firet, and the use of the data considered thereaf'terq ,. . The funds zoquirod for tho VSC vozk are covered in our 1956 budget, and I propose to authorizo tham to proceed tnaless yw objeot. %., hia propauod resaarch protocolq I am enclosing a o of Dr4 Xotin'e letter of JUlq 9th and CTR HN 026477 . a