Tobacco Documents Online

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Txr. CorNcIL For. ToBAcco RrscAr.cx-L'.S.A.. Isc. t Colorado Project I CTR Grant No. 1076 $502,914 for a three year study. (Apri1 1, 1976) Title: FIesedity and Tobacco-Related Behavior in the Mouse ' Recipie.zts : Principle Investigator ' Gerald E% McClearn, Pb.D. Director, Institute for Bbhavioral Genetics Department of Psychology, School of Pha.•-s.acy University of Colorado, Boulder, Col. 80309 Co-Investigators Herbert P. Alpern, Ph.D., Associate Professor of Psychology, ibid Allan C. Collins, Ph.D., Fe11ow, Institute for Behavioral Genetics, ibid Virgel G. Irvin, Ph.D., Associate Prof. of Phiraacology & Dean, School of Pbarmacy, ibid Ktat Schlesinger, Ph.D., Professor of Psychology, ibid Seth X. Sharpless, Ph.D., Professor of Psychology, ibid Jaaes R. Wilson, Ph.D., Associate Professor of Psychology, Biology a:.d Behavioral Genetics; Associate Director of the Institute for Behavioral Genetics, ibid Patricia Clark Ratchell, Ph.D., Research Associate, ibid. Brief Description of Aims (by the Grantees) "Although a substantial literature has accueulated conee.rning the relevance of heredity to a variety of behaviors related to drugs, relatively little resea.-ch has been done on genetics aad tobacco use." "The issue of individual differences, which is sine qua non for genetic research, was draaatically illuminated when Fi:her applied the well-known aphorisn that 'correlation does not imply causation' to the described association between smoking and lung cancer. Considerable interest has been aroused by the postulation that individuals of a particular genotype nsay have both an enhanced tendency to smoke and, independently, an enhanced tendency to develop lung cancer. This postulation gains some credibility from the few published studies of htiasan tvins' amoldng behavior and of differential behavioral response of inbred mouse strains to admiaistration of nicotine. These studies strongly suggest that there are iatportant hereditary influwences on tobacco-related behavior, but the total evidence can only be regarded as pramissory. The general objective of the proposed research is to ftiather knowledge in this area, nsing me mouse as an szperimental organism." "We shall first focus attention on nicotine. In later stages of the resea_-c5, we shall broaden the scope of the investigation to consider-othes coBponents of tobacco a.nd their metabolites. Evidence vill be sought for genetic influence on individual differences both in behavior toward nicotine and in the effects of nicotine on behavior. Appetitive behavior vill be assessed by preference testing aad by operant procedures with indweltiag catheters. The effects of acute and chronic administration of nicotine will be assessed with respect to E.~ ! E',, F 't 0284 '(~