Council for Tobacco Research
Project 0100 - Objective for 1964 [Regarding Development of A Medically Acceptable Cigarette in Light of Present Health Attitude]
Abstract
MAR
Fields
- Type
- MEMORANDUM
- MINUTES
- Depository Date
- 25 Sep 1995
- Recipient
- Bavley, A.
- Master ID
- Ctrmn00028023-9276
- CTRMN028023-8033 Philip Morris Research Center Smoking and Health Significance of the Report of the Surgeon General's Committee to Philip Morris Incorporated Evaluation Report [Discussion About the Examination of the Report of the Surgeon General's Advisory Committee on Smoking and Health and Their Findings]
- CTRMN028039-8039 the Journal of the Medical Society of New Jersey Vol. Xxxi, No. 2 [Information Regarding Calcreose]
- CTRMN028040-8040 Some Folks Seem to Think You Can Change Quality- [Advertisement for Chesterfield Cigarettes]
- CTRMN028041-8041 No Susceptible Person Need Have Scarlet Fever [Information About the Effectiveness of Scarlet Fever Toxin in the Prevention of Scarlet Fever]
- CTRMN028042-8042 Please Ask US.... The Pennsylvania Medical Journal [Information Regarding Questions One Might Have Regarding the Physiological Effects of Smoking]
- CTRMN028043-8043 Call on US! [Offer of Information Regarding the Effects of Smoking]
- CTRMN028044-8044 the 17th Annual Meeting in Haddon Hall, Atlantic City, June 4,5 and 6, 1940 [Index of the Different Articles in the Magazine]
- CTRMN028045-8045 What Happened When Smokers Changed to Philip Morris? Vol. Xlv, No. 2, 149-154 [Comments Regarding the Wonderful Effects When Smokers Switch to Philip Morris]
- CTRMN028046-8046 the Third Fall Clinic Conference of the Medical Society of New Jersey, in Essex County, November 27 and 28, 1940 See Announcement Page 491 Vol. Xxxvii, No. 10 [Index of Articles Featured in the Journal]
- CTRMN028047-8047 the Journal of the Medical Society of New Jersey Cigarette Differences As Shown on the Rabbit-Eye Test Volume Xxxvil Number 10 [Showing of Experiment Done on Rabbit Eye with Solution From Philip Morris Cigarettes and Solution From Ordinary Cigarettes]
- CTRMN028048-8048 Take No One's Word But Your Own [Comments Regarding Philip Morris' Cigarettes in Relation to Respiratory Problems]
- CTRMN028049-8049 Arizona Medicine Vol. 2, No. 1 Not Only Laboratory Tests But Also... Clinical Tests [Statements That Clinically Prove Philip Morris Cigarettes to Be Definitely and Measurably Less Irritating]
- CTRMN028050-8050 Simple Test Prove Instantly Philip Morris Are Less Irritating [Instructions on How to Confirm for One's Self That Philip Morris Cigarettes Are Less Irritating]
- CTRMN028051-8053 L&M - A Perspective Review [Discussion on the Reduction of Harmful Chemicals in Cigarettes]
- CTRMN028054-8054 Liggett Responds to Press Report on New Tobacco Research Vol. 4, No. 30 [Discussion About Ligget & Meyers Tobacco Company Receiving A U.S. Patent Covering the Development of A Catalytic Process]
- CTRMN028055-8056 N.C. Company 1rst to Admit Tobacco Link to Rat Cancers [Discussion on How Liggett & Meyers Company Is the First Cigarette Maker to Acknowledge That Tobacco Causes Cancer on Lab Animals]
- CTRMN028057-8078 [St]
- CTRMN028079-8109 Challenges in Tobacco Research [Discussion on the History of Tobacco and the Research It Involves]
- CTRMN028110-8149 Outline of Topics to Be Discussed at Research Conference to Be Held on November 22 and 23, 1955 [Details on Subjects Needed to Be Discussed at the Research Conference]
- CTRMN028150-8222 Topics to Be Discussed at the Research Conference in Durham N.C. On October 22 and 23, 1958 [Lists of Subjects to Be Discussed at Conference]
- CTRMN028223-8223 Sloan - Kettering Contributions [Discussionon About James Bowlings Thoughts on the Sloan - Kettering Contributions]
- CTRMN028224-8227 [Notification of Draft Letter Enclosed in Document]
- CTRMN028228-8240 An Outline of Current and Proposed Quality Control, Development and Research for Beason and Hedges [Discussion on the Program of Quality Control]
- CTRMN028241-8244 [Discussion of Wynder's Findings on the Connection of Cigarette's and Mouse Skin Tumor Incidents]
- CTRMN028245-8284 Xa Scientific History [Objectives of Wynder's Studies]
- CTRMN028285-8287 Corporate Objective: [Objectives for Cigarette Manufacturing]
- CTRMN028288-8302 Statements of Purpose and/or Objectives [Information Regarding Smoking and Tobacco Use and Its Health Effects]
- CTRMN028303-8304 Proposal to Include A Skin Painting Test at Adl to Evaluate the Level of Tumor Promoters in Smoke From Cigarettes Treated with the Catalyst Mixture [Cigarette Modification Test to Be Run with 100 Mice]
- CTRMN028305-8306 Statement on What We Think That We Have Accomplished on Project Xa-5001 [Development of Cigarette System Which Produces Smoke with Reduced Biological Activity]
- CTRMN028307-8308 Brief Comments on A Program to Produce A Low Delivery Filter Cigarette with Flavor [Goal of Reducing Tar Delivery and Identifying Carcinogenic Substances]
- CTRMN028309-8315 Statement of H.H. Rahn to the Executive Committee of the Council for Tobacco Research - J.S.A. [Request to Find Scientific Director]
- CTRMN028316-8326 Ind. Research Committee [Information Regarding Human Behavior As Related to Smoking]
- CTRMN028327-8328 [Description of Cancer Research for Which Support Will Be Needed]
- CTRMN028329-8330 Proposed Study by Alvin R. Feinstein, M.D. Of the Natural Course and Post-Therapeutic Outcome of Cancers of the Lung, Larynx and Rectum [Feinstein's Work Inspired by De. Ian Macdonald's Theories of Biological Predeterminism]
- CTRMN028331-8333 [Recording of Essential Features of Recent Telephone Conversation Concerning the Funding and Operation of Pending Research]
- CTRMN028334-8334 [Request for Support of Planning Grant for Nasopulmonary Research]
- CTRMN028335-8336 [Suggestion of Having Dr. John Vivian Wells As Principal Investigator of Study for Linkage of Certain Gm Genotypes to Chronic Obstructive Disease]
- CTRMN028337-8337 Ctr Special Projects [Description of Research Projects, Researcher]
- CTRMN028338-8340 [Budget to Enable Completion of Volume on Environmental Factors and Causes of Death]
- CTRMN028341-8346 Ctr Special Projects [Description of Research Projects, Researcher]
- CTRMN028347-8352 Ctr Special Projects [Description of Research Projects, Researcher]
- CTRMN028353-8358 Ctr Special Projects [Description of Research Projects, Researcher]
- CTRMN028359-8363 Meeting of General Counsel on December 17, 1965 [St]
- CTRMN028364-8371 Outline for President's Office Presentation Appraisal of the Present & Future Contributions of the Research Department to the Corporation (Tobacco Only) [Four Major Work Areas in Research Department]
- CTRMN028372-8396 Tobacco and Health-R&D Approach Presentation to R&D Committee by Dr. H. Wakeman at Meeting Held in New York Office [Chemistry of Cigarette Smoke]
- CTRMN028397-8398 "Policy Regarding the "Tar Derby"" [Suggestion to Diversify Business at A More Rapid Rate]
- CTRMN028403-8403 All Burley Cigarette [All Smoke Condensates But Burley Cigarette Were Judged to Be Carcinogenic to Mouse Skin Suggestion to Publish Results and Manufacture and Market All-Burley Cigarette]
- CTRMN028404-8406 H. Wakeham Presentation to Philip Morris Board [Brief Description of Five-Year Plan for Research and Development]
- CTRMN028407-8408 "Proposal for the Evaluation of "Project Better" Cigarettes" [Formation of Two All-Tobacco Filler Blend Cigarettes Cost Estimate for Testing]
- CTRMN028409-8409 [Experiments on Catalysts for Work on Cigarette Manufacture]
- CTRMN028410-8411 Statement of F.G. Bock in Buffalo, N.Y. On October 12, 1956 [Concerns Over Statistical Associations of Smoking to Lung and Bladder Cancer]
- CTRMN028412-8413 [Question of Improving and Enlarging the Scope of the Scientific Advisory Board Programs]
- CTRMN028414-8416 Public Relations Report to the Tobacco Industry Research Committee [Role of Public Relations Department and Treatment of Smoking by the Press]
- CTRMN028417-8425 [General Comment on the Current Status of the Tobacco and Health Situation]
- CTRMN028426-8432 [Regarding Current Position of the Committee's Program and Progress, and Course for the Future]
- CTRMN028433-8434 [Discussion of TIRC Program History and Goals]
- CTRMN028435-8436 Source & Use [Record of Amounts Received or Due From Contributors]
- CTRMN028437-8438 [Comments on Report From Jefferson Medical College on the Effect of Cigarette Smoke on Pulmonary Clearance]
- CTRMN028439-8443 Proposed Fields of Research [Present Situation Plans for Future Work]
- CTRMN028444-8445 [Thoughts Concerning Some of the Problems of the Tobacco Industry]
- CTRMN028446-8447 Research Project Suggestions [Possible Projects Including Population Studies to Link Smoking to Mortality, Etc.]
- CTRMN028448-8456 Suggested Guidelines for Industry Committee for the Review of Industry's Overall Independent Scientific Research Effort [Determining Industries Short and Long Term Objectives for Research]
- CTRMN028457-8458 [Individuals of Major Manufacturers That Will Represent Their Companies on the Committee to Study Research Programs Funded by the Industry]
- CTRMN028459-8463 [Overview of the Organizations Contributing to Research Into Tobacco and Health]
- CTRMN028464-8467 Industry Research Committee [Enclosing Copy of Report Submitted During Moss Hearings and Copies of Letter From Janet Brown and Memo From Ed Jacob on Industry Research Efforts]
- CTRMN028468-8469 "Tobacco Industry Sponsored Instructional Project on "Genetics and Environmental Bases of Tobacco Related Behavior."" [Recommendation of A Five-Year Study As A Special Project by the Council of Tobacco Research]
- CTRMN028470-8470 [Opinions Concerning the Ucla Research Effort Supported by Tobacco Companies]
- CTRMN028471-8472 [Projects in Colorado]
- CTRMN028473-8475 C.T.R. Meeting [Discussion of Cash-Flow Analysis Comparing Commitments Vs. Pay-Outs]
- CTRMN028476-8477 [Discovery on New Product Advantages of Ventilated Cigarettes]
- CTRMN028478-8478 Your Letter to Mr. Allen About Tobacco Industries Participation - Phone Call From Dr. Kensler ["Question of "Confidential" and "Classified" Material"]
- CTRMN028479-8485 Summary of Dr. Hocketts Comments [Report of the Surgeon General's Advisory Committee on Smoking and Health]
- CTRMN028486-8486 [Suggestion to Gain Victory One One Front at A Time]
- CTRMN028487-8490 the Roper Proposal [Comments and Suggestions on the Strategy of the Tobacco Industry]
- CTRMN028491-8498 [Comment on Ctr Decision Not to Continue Support for Studies on Smoke Inhalation in Inbred Syrian Hamsters and Plea for Continuation]
- CTRMN028499-8502 [Discussion of Publishing Paper on Smoke Exposure to Hamsters]
- CTRMN028503-8505 Report to Ctr Annual Meeting, Jan 31, 1975 [Discussion of Favorable Press Coverage During the Previous Year]
- CTRMN028506-8509 [Ama Opposition of Proposed Industry-Wide Rules]
- CTRMN028510-8516 Planning [Comments on Priorities of Research]
- CTRMN028517-8519 [Comments Regarding Research Program to Target Consistent Problems in the Industry]
- CTRMN028520-8524 Comments on Ama-Erf Program for Tobacco and Health From the Research Directors of the Supporting Companies [Scientific Representatives Attending the Ama-Erf Presentations Say Half the Program Was Not Relevant to Smoking]
- CTRMN028525-8539 Remarks by Ernie C. Clements, President Annual Meeting, the Tobacco Institute, Inc. [Information Regarding Division of Responsibility and Statement of Objectives]
- CTRMN028540-8543 [Mention of Tim's Impressions of the New Offices]
- CTRMN028544-8545 [Talks with Dr. Huber, Dr. Rabkin and Dave Hardy Concerning the Harvard Project]
- CTRMN028546-8549 [Suggestion That Harvard Proposal Be Accepted in Principal]
- CTRMN028550-8551 [Status of Special Project 98]
- CTRMN028552-8554 the Gallop Poll Public Opinion Volume Two 1949-1958 [Questions on A Variety of Topics]
- CTRMN028555-8602 Doctors and Smoking (III) Their Smoking Habits, Their Advice to Patients on Smoking, and Their Views on the Correlation Between Cigarette Smoking and Lung Cancer and on Research Conducted Thereon [Number of Non-Smokers Increasing Largest Percentage of Quitters Is Physicians]
- CTRMN028603-8608 the Gallup Poll Public Opinion Volume Two 1949-1958 [Questions on A Variety of Topics]
- CTRMN028609-8611 the Gallup Poll Public Opinion Volume Two 1949-1958 [Questions on A Variety of Topics]
- CTRMN028612-8660 Doctors and Smoking (IV) Their Smoking Habits, Their Advice to Patients on Smoking, and Their Views on the Correlation Between Cigarette Smoking and Lung Cancer and on Research Conducted Thereon [Smoking Has Decreased Significantly Among Physicians From March 1957 to August 1959 and Among Those Who Do Smoke, Most Only Smoke Cigarettes]
- CTRMN028661-8665 Research Summary [Method and Consensus of Results From 4 Presearch Sessions]
- CTRMN028666-8667 1950-1974 Per Capita Cigarette Consumption (18 and Over) Gross Cigarette Consumption (Billions) [Despite Periodic Drops, Cigarette Consumption Has Risen Steadily From 1950-1974]
- CTRMN028668-8689 Verbatim Transcripts of Radio Broadcasts Photographic Transcripts of Television Broadcasts ["Transcript of Arthur Godfrey and the "Chesterfield Show""]
- CTRMN028690-8690 [Invitation to Visit Laboratory and Examine Sections]
- CTRMN028691-8701 [Thank You for Invite Dr. Sommers Out of Town Until June 29]
- CTRMN028702-8716 Proposals for Discussions at July 9 Meeting [Transmittal of Proposals to Use As A Guide for Public Relations Part of Agenda]
- CTRMN028717-8723 Distribution of Tobacco and Health and Tobacco News [Publications to Be Sent to Subcommittee and Public Relations Committee]
- CTRMN028724-8747 Public Relations and Budget Proposals [Public Relations Program Designed to Meet the Industry's Challenges in Health and Create Understanding of Issues]
- CTRMN028748A-8751 Scientists Report...Human Virus Induces Animal Lung Cancers [Cancer Responsible for Respiratory Disorders]
- CTRMN028748B-8751 Primary Lung Cancers Found in Study of Nuns [Report Shows Cancer Can Occur in Women with Little or No Smoking History]
- CTRMN028748C-8751 New Research Work Raises Questions About Origins, Types of Lung Cancer [Find Most Cancers Start in Periphery of Bronchial Tree, Not in Main Bronchi]
- CTRMN028748D-8751 New Research Work Raises Questions About Origins, Types of Lung Cancer [Study Shows Decline in Epidermal Cancer Frequency in Males]
- CTRMN028748E-8751 Study of 163 U.S. Areas Shows...Lung Cancer Death Rate Vary Widely [Sharp Differences Exist Even in Similar Size Cities and Similar Geographic Areas]
- CTRMN028748F-8749 Chest Specialist Says...Basic Cancer Data Being Obscured [Professor Calls for Renewal of Investigation Into Association of Smoking and Lung Cancer]
- CTRMN028748G-8749 Study Questions Accuracy of Death Certificates [Certificates Are Unreliable to Use As An Indication of Incidence of Cancer]
- CTRMN028748H-8750 Report by Little Cites New Tests, Human Type Tumors in Animals [Means Are at Hand to Design Tests to Evaluate Influence of Internal and External Factors on Inducing Cancer in Animals]
- CTRMN028748I-8750 Study Finds Cancers Arise in Lung Scars [Close Relationship Exists Between Scars and Development of Cancer]
- CTRMN028748J-8751 ""Competing Risks"...Diseases Have More Than One Cause" [Consensus Is All Disorders Have More Than A Single Cause]
- CTRMN028752A-8752 Virus Causes Lung Cancer in Animals [Ordinary Viruses May Play A Contributing Part in Human Cancer]
- CTRMN028752B-8752 Air Pollution Blamed for Lung Cancer [Report by Government Physician Regarding Cancer Causes]
- CTRMN028752C-8752 Cigarette Makers New Survey Disputes Tobacco-Cancer Link [Cigarette Factory Employees, Who Smoke Nearly Twice the Average, Live Longer and Have Less Incidences of Cancer]
- CTRMN028753A-8753 Finnish Doctor Challenges Cigaret-Heart Ill Link [Questions of Cholesterol Levels Arise]
- CTRMN028753B-8753 Lung Cancer Linked to Auto Exhaust [Political Steps Should Be Taken Against Air Pollution]
- CTRMN028753C-8753 Japanese Research Finds No Link Between Lung Cancer, Cigarettes [Scientists Also Rule Out Exhaust Fumes As A Cause of Cancer]
- CTRMN028754-8760 Heavy Smokers with Low Mortality A 14 1/4-Year Test of the Cigarette Hypothesis of Lung Cancer Causation Industrial Medicine and Surgery, 31.3, 115-120 [St Paper Extends Mortality Rates of Cigarette Division Employees of the American Tobacco Company]
- CTRMN028761-8785 TI Annual Meeting Remarks by R.W. Darrow [Suggestion of Hill and Knowlton to Continue, on A Reduced Budget Proposal, the Regular Public Relations Activities That Have Proved Helpful in the Past]
- CTRMN028786-8789 Tobacco and Health Research Procedural Memo [Instructions on Writing and Production of Publication]
- CTRMN028790-8796 [Comments on Suggested Guidelines for the Industry Committee on Scientific Research]
- CTRMN028797-8797 [Meeting with Burton Marstellar Leads to Decision to Present Draft Statement to Full Communications Committee]
- CTRMN028798-8798 A Frank Statement to Cigarette Smokers [Statement of Recent Reports on Tobacco]
- CTRMN028799-8800 Tobacco Research Fund Raised to $1,500,000 [Support Will Enable Effort to Fill Gaps in Scientific Knowledge]
- CTRMN028801-8801 Cigaret Theory of Cancer Hit [Blaming Lung Cancer on Smoking Is Retarding Research Into Actual Cause]
- CTRMN028802-8804 Three Scientists Raise Questions About Cigarette-Cancer Theory [Scientist Claims Causal Relationship of Cigarette Smoking to Lung Cancer Is Unproved]
- CTRMN028805-8805 Cigaret Theory of Cancer Hit [Blaming Lung Cancer on Smoking Is Retarding Research Into Actual Cause]
- CTRMN028806-8902 Bird-I A Study of the Quit-Smoking Campaign in Greenfield, Iowa, in Conjunction with the Movie, Cold Turkey [55% of Smokers Who Quit Cold Turkey Gave Up Smoking for at Least A Month and 28.3% of Them Were Still Non-Smokers Eight Months Later]
- CTRMN028903-8905 [Recommendations for Industry Research Prepared Last Year]
- CTRMN028906-8910 [Thoughts on Things That Need to Be Done]
- CTRMN028911-8913 Confidential Report Tobacco Research Committee Meeting [St]
- CTRMN028914-8920 Remarks by Earle C. Clements, Prepared for the Board of Directors Meeting at the Spring Meeting of the Tobacco Institute [Discussion of Evaluation of Strengths and Weaknesses of Tobacco Institute]
- CTRMN028921-8921 Industry Research Liasion Committee Meeting, May 15, 1975 [Discussion of Insufficient Space for Some Laboratory Aspects of Harvard Project]
- CTRMN028922-9276 Dr Little Comments on January Applications [St]
Related Documents:
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CONFiDENTI1
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TO i Dr. A. 8av1y DATL: Novisher 21, 1963
PROM r R. H. 8laclaaor.
SUBJLCT: Pro.lect 0100 - Obieetive for 1964
A plannins mr+tina to establish the major objectives for
project 0100 during 1964 was hld In Conference Rooa "A" with
the following persons In attsndanc: Dr. A. Savlay, Dr. E. V. Robb,
Dr. R. M. Cream.r, Dr. V. Johnaon, 14. R. D. Carpenter and
Dr. R. H. Dlaekmor..
DT. Satly prefaced the s»etina with the statsrnt that -
the major object of the Research Division for 1964 1s to develop
a"Mdically Acceptable" Cigarett In light of the present
health attitude. The aiau ol the smoke eheaiatry group should b*
swr specific than In the past. We aust not forget the major
goals of the Division and bcosr bogged down in procedures on
analytieal methodologies. Por example, on of our major purposes
is to remove polynuclear hydrocarbons from cigar.tta snok., not
just to develop a arthod of detecting bnzo(a)pyrene In smoke.
Dr. Davl then stated that w should approach the problem
with definite 'bench marks" in aind.
Vhat are the "bench marks" in the Smoke Chsdatry Probleat
1. Nicotine removal. Accomplished - using low nicotine
o acco an or extractd tobacco to remove nicotine
slectivity from tobacco.
2. Renaval of hnol. Accomplished by nrans of th
iTT os ac filter with plasticizers.
3. tol clear h droearbons removal. v should hav
a CO{QD f / - ma or effort.
4. Nitrosaains removal. V. ahould also have this
comp . r .
Status of Polynuclar Hidroc u-bon Removal Proe Sieo_k+_. ~A
An iAprovd analytical method for the daters:ination of ~
benzo(a)pyrn and several other polynuclear hydrocarbons .hould C
be completely worked out by January 31, 1964. This will enabl
screening of various chenical additivea and/or treatmenta of Gn
eigartts for polynuclear hydrocarbons delivery. N
C63-00148
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This basic study in the development of an analytical procedure
was necessary because previous PNHC methods were not satisfactory
for our screening experiments. This new screening procedure will
be superior to any knor+n published method and will provide us
with the means of better understanding the entire PMiC problem.
Now that a screening procedure is nearly perfected, we
must plan our experiments in such a way that we can insure the
maximum degree of success from a limited number of experiments
without going through the entire gamut of possible experiments.
Dr. Bavley then asked, what are the possible assumptions
on the formation of polynuclear hydrocarbons? -
1. Polynuclear hydrocarbons are formed from products of
incomplete combustion primarily cellulose and other
non-volatile tobacco constituents.
2. Polynuclear hydrocarbons are formed during pyrolysia
3.
of tobacco constituents by means of free radicals
(polymerization of free radicals).
Polynuclear hydrocarbons are formed from nuclear re-
arrangement of steroid type compounds in tobacco,
(we probably can forget about this hypothesis).
What are the operational steps which we can take to study
these hypotheses?
I
1. Review the patents and literature which claim various
additives incorporated into tobacco for reducing the
amount of polyrTuclear hydrocarbons in cigarette amoke.
(Study a few of these which seem most likely to succeed.)
2. Investigate the formation of polynuclear hydrocarbons
during the aging of tobacco emoke. Measurements of
the charge of particles and their free spin energies
might be helpful in this study.
3. Study the effect of selective additives to tobacco
based on the rational theories in the formation of
polynuclear hydrocarbons according to aesumptiona
one and two. For example, what stops or prevents the
formation of free radicals or blocks their polymerization
into complex polynuclear hydrocarbons?
(a) Hydrogen transfer agents (alcohols, rater, acids,
triphenylmethane, etc., compounds with acidic
hydrogen atoms).
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(b) Active oxygen doners, peroxides, halogen ions,
(c) etc.
Metals
with high oxidation states (V, W, Ti, etc.).
(d) Interaction techniques, alkylation for example;
free metals themselves; organometallic salts
such as Versenes or Ferrocene.
Dr. Bavley stated that this will give an example how
intuitive invention works. We should develop this type of
thinking and expand on other possibilities.
Looking into assumption or hypothesis number one, what
affects complete combustion? Complete combustion may not be
the answer to the problem; we may want only increased oxidation.
How can we increase oxidation of the burning cigarette? ~
(a) Increase the porosity of the cigarette paper.
(b) Addition of peroxides or oxygen donors to tobacco.
(c) Blowing agents (carriers of oxygen). ~
(d) Catalystssuch as Pt, Pd, etc.
(e) Treatment of tobacco with nitrates or other similar
substances which burn more fully.
(f) Possible enzyme treatment of tobaccos to produce
degradation products which burn differently.
We should formulate definite plans as to the method of
studying these ideas.
Use of a cellulose model has been thought to be the best
means of approach. Dr. Bavley suggested using base TFP as starting
material. This would have considerable support to the Research
Center and would be favorably received by top management. '
We should develop a protocol which lists definite goals
towards the development of a proto-type "Medically Acceptable"
~
cigarette by the end of 1964. C
~
As soon as a breakthrough is obtained in reducing PNHC ~
formation, the modified cigarettes will be screened by skin -
testing of animals and by respiratory animal studies as well L~
as the usually chemical analyses of cigarette smoke. (b
~
Dr. Bavley asked,Nhat do we know about nitroso compounds?" Ut
Nitroso compounds appear to rise from:
(a) Alkaloids in tobaccos.
COPY
(b) Nitrogenous materials which upon burning give rise
to NO and NOz.
(c) Nitrates and other nitrogen compounds. -
.
(d) Catalytic fixation of Ni and Oa during combuetlon: ~~o ,
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Dr. Bavlev: "Conditions for Nitroso Pormation?"
1. Formed from oxides of nitrogen.
2. Something present to react with NO or NO2, (aliphatic,
olefinic, and cyclic secondary araines).
Dr. Bavley: "How Can We Eli:ninate Nitrosamines?"
(a) Interfere with their formation by using scavengers
(b)
C)
(d) for oxides of nitrogen. -
Reduce amine reaction of alkaloids by adding ~
something more reactive than the alkaloids.
(Ferrocene, phosphites or hypophosphorous salts
might be effective)
Use tobaccos low in nitrates.
Selective additives which would reduce nitrogen
oxides to elemental N.
I
We have already developed a crude analytical method for
detecting nitrosamines in tobacco smoke. We are unable to
determine specific nitrosamines at this time on a routine basis.
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