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0 HRO`cti:~ ~ ~NILLIA_~IBO~ TODAC:CA COIit'ORATIO\ ` ~ 1600 144+s M:. So..c • La.ievtitL. hsRtti.cky i0201 ~ {AV[S .. ..r,~. Otl~uk .AT.~Cc M I... Januazy 3, 1966 LAM D[VAATrtAT •GD~jC% VtaW•.. ..t~ .~. ls.ssra. Raas ~ lto t sko R:.ra ftussall Smitn Ii you find anr a..d.d corr.ctions or ch:.a6.s in tD• •ncloc.d, Dl.asc not• tDa at o..tin= of Couns.l on Thursday, Januzry 6. AY r.a 99 pWNTIFF'S EXHIBIT oT.~B _____- .,...~,.a..,~,. m I C TR- HN 0 ~~3 IEZ ~

./ Re: ZS.eting of General Couns.l on I4 cenber 17, 1965 I loo PursLant to reQuest fros General Counse1 of eacb of the six participatint companies, the Ad Hoc Cotaittee submitted aevon proposals for specific research projecta t+hicn, in thei.r vie., deserved ic"diat• inplementation: 1) Prof. Lucio Severl, Director and Dean, Istituto di Anatonia • Istolo0ia Patologica, Perti:Gia Nature of Project: "aork on tDo rul:+tion Lc:tWoon in anivals ana isonasio." Estimated Cost: .520,000 luag tursours Action: To b• svbsitted to S.A.D., C.T.t.; ii not appioved, t he project will b• earried.out by C.T.R. under its "special pro,lects." 2) Geoffrey L. arinkmao, M.D. Nature of Project: Selection of sections which C-rot;ly appear to be adjacezt to rulictant tuaors for exacination endar an electron nicrosccpe to determi:.• vhothor the claiced dociliation and cell cbanges at the tumor*site nave occurred. ::s~iaated Cost: 33,000-54,000, with possible later applic:.:ior. "to the appropriate organization" for extea- sion of the work to a larter auzber of cas:s. Action: • Approved Sor im?lesr.entation by C.T.R. special •• pro3octs in close cooperation with the iAd Eoc CoZaittee. 3) kiraa Iangston, M.D. Naturu of Project: Analysis of records of patients at Yetcra:s Administration Hospital in Hines, Illinois, to determine age of pcak incidenco of bro:cho- Cenic carcinomi.. Dr. Langston's work bco:s on tbe importance of dosago factor in resrcct of sttioki nQ. "tieuted Cost: $2,000-S3,000 ~~. Action: .'.uthorizod, under svporvision of the Ad Hoc Comaitteo, exDons• to be handled throu;h Central Fllo. C TR H N 0 22 8 3` G- ( )

M.etinj of 12-17-65"' - 2 - i a 4) InvestiCatioa of "population pockets" T.avin; a high ir.cidance of lung cancor with very lov per capita consumption of cigarettes. Est imated Cost : $600 P.E.S. Palter, Departatnt of Radiolo;y, University of Cape Tovn, South Africa Nature of Project: 5) Leo Katz, ?rofessor of Statistics anc: Director of the Statistical Laboratory, :licAiraa State Vniversity; Visitint Professor of Bio-Statistics, L'adical School, University of Cincinnsti. Action: Ap;roved; to be hancl:d by Ad lioc Co:mittec; expens-a to be borne tt.rou;h Central Fi1e. Nature of Project: Design of a yilot exptriment to induce.s=all laboratory •r.imals to smoLe to detormina feasibiiity of buildia; "behavior In t:ese aninsls as c:oso as yoisible to that of hut:..u vatD %-;Ldy oi psy%%j.olo;;ic:l c'har:ct~-ristics of the sr.o:anr ar.i:~ls as coopared vith non-s::ocia; aninals." Es:irsted Cost: (a) Approxitaatoly $2,000 to :lichi;:an Sta:e Universi:y for anic"als, d~velopneat of sUO::in2 rig, laboratory technicians' t i:e, plus overhead, and (b) consultant fees to 'Drs.Xotz, De :ay and P.atnar. Approved, C.T.R. to furnish finaacine under itaa (a) and er.pcases under item (b) to be borre t hrough Central Filo. 6) :. Alv :n R.. Feinstein, Dapartr.ent of Internal i:od:cine, :chool of liedicine, Yale University. Ka-:ure of Pro3ect: "Relationship oi ci;arette =Dokir.t, to tr.e clinical courie and behavior of cancers o: the lung, lay yrx and roctun, "with part ic,.j1ar refcrence to "t~e devolopaent of techni4ucs of tultivariatle analysis." :~a:it:.ted Cost: $5,600. /0/ ;.,;ion: Approved; to be haadlod through C.T.R. s-cc:c: projects In coc;.eration with ar. E.J. J-cob. tr tR t! t't 02836.t

Y.etinr ot 1~-17-6:.i - 3- ~ 7) Jaaes F. Smitb, D,D.S., Ph.d., :.s;aci:te Professor of Pathology, Institute of PatholoCy, Univor Nature of Project: Study ot tba relation snuff, and otber uses of cancer of the lip, the s.outb, pa:ate, to Estimated Cost: Not detormined, but i: lrou those proposals. of etce r of Action: Ar. Saitb will be aa'ea to submit a stato:.en: ot th. purposo of Dis vork and an appropriate p•roposal to C.T,R. for grant. ' Final act ion will avait evaluation ot that proposal. Tbe Ad Boc Co=aittse ribmitt.d its "priorities" selected iroea tEe reco=.nc:ations for specific research pr.sented to G.noral Counsel at an et~ lier %ootinQ. R.f.rences Aereinafter will be as appear T~..o Ad 8oc Coamittoe divided the proposals referr.d to into three ca:o;ories: ~ Ca eLory A: ?rojects essentially of "adversary" value. { Tboso are considerbd to have a relatively hi;h ' priority, ' Ca;eCory B: ?.osoaxch b.aviz,• a Cazerally defensive cbaracter. Ca-zegory C: 8asic researcb. • Lo::.:led consideration ras Civea to the folloaing projects under C:.:r;;ory A; tbore Sollows ny notes of the action taken: :-s; :I-2t Approved for bzadling by C.T.R. special pro)ects. II-1,3,4 . Approved and tivea bi;b priority for h3ndlir.; by Ad }ioc and lazCin;, hopofully, to respons:ble articles for publication. No estimato of cost. II-~ Approvod for ins.dlate action undor Ad Hoc Coraroittee direction. I II-S,S4 •Luthorizod for itLmediate action; 11-5 undcr tro direction of Ad Hoc Corijittoo und 1I-44 for handling by C.T,R, spccial projects. i T-o, 3, 10, 22, To bo banalod by C.T,R, special p: o;ect s, Dr. 23,32,33 Hockott to sub::it a preliminary plaa for /n • i4plenenta:ion. (~ Ii-14,15,13 Authorized, Sor action by C.T.R, special pro.)ec:s on II-14,15 and 11-16 to be the responsibili:y of Ad Hoc Co=ittsi. C~ ~ Cl R E tN 02Qt 3

0 ... - .~ •i... •. . OEW ® ® 1P_ t H.etin; of 12-17-6S `' - 4 - rM II-28,30,31 Wnerally to be b:ndled by C.T.R, special p:ojects, bu: to be re-sta;ed to express stort tern projects available, as opposed to 1ong ters, and rs-subaitted. V-2 Committ*t. , Approvsd for action by Ad Hoc Coa.citteo. III-Z Authorized tor b~ndlinr by C.T.R, sp.cial pro- jects and Civ.n biCh priority, III-14 Approved for haadlin; by C,T.R, special project coopsratin; vitA Ad Y.oc and Siven high priority 11-48 III-17; IY-S Def.rr.d, pcndin; prorr.ss of Dr. IanQiton's special pro,;Ioct ;u•:boriz.d abov.. 111-26 Authorizsd under sv;.orvision of Ad Hoc Comnittee ~ YII•31 hd boc to lnvostiC:.:• further. witb c_rtlcul1r rif.r.ncs to available reses IV-10 9I-S costs. To be ro-subcitted, ..Au:borized unde: sapervision Qiy.n high priority. ~ Ad'Xoc to submit specif:c pr •stimat.d costs. d(0 'AIA- It ::; unda: s:ood tb.at both C,?,R., `ia respect of its special pro; ect s nt:,: ;:.a Ad ::r-c Couzitte• vill as occaL:on vaxrints, but upon no iixec sc,:rwls, r,&;yort tbo status of all projects as tb.y proceed to Gaz3:':.1 Cour.:ol, It is also ucd,irstood th.it botD C,T.R, tp+cial praj:,c:s :.:.d Ad Soc •ill to tho fulles: extent possible ndvito C4noral CounL.l of the •stinated cost of specific projects and cuint= t.1i accouatin3 of actual •xpindituros. In particular the Ad Koc Co=itte s is not authorized to =ko com=itaont for expenses rithout p:rsviouu svbnission to a.nd approval by General Counsel. /43 A, Y. I ts 11-47; IY-1,9; Authorized under tne supervision of Ad Hoc ls i9 R11N