Tobacco Documents Online

h ~ CO}ffIDETIAL C UnivQrsity of Hawaii at Manoa Beb.viorel 8iolo=y Laboretory Pecilic Biomediul Research Center Snyder Hill 215 .233E The btall. Nonc 'j. Hawaii o6t!22 Telephone: t;:9-D9ss April 11, 1975 Mr. Edwin J. Jacob Jacob t Medinger 1270 Avenue of the Americas Rockefeller Plaza t:eta York, N.Y. 10020 Dear Ed: This letter is for the purpose of recording the essential features of our recent telephone conversations concerning the funding and operation of the pending research program on genetics and tobacco-related behaviors. It has been agreed by the investigators that I should serve as coordinating investigator. In this role, I would serve as the co-:,unication link between the investigators and the granting cor.sortiLLn. I would be responsible for coordinating the preparation and subnittal of required fiscal and scientific progress reports and arranging for periodic meetings of the consulting and review panel. Responsibility for the scientific conduct of the research would be assur.ted by the principal investigators of the three separate projects, as follows: Hawaii study -- Geoffrey Ashton Half sib-twin study -- Wilson Crum?acker and Steven Vandenberg Animal study -- Gerald E. 1•1cClearn PLAINTIFF'S EXHIBIT OSL .~r...,,a......«~ CTR H~~ ~~~~3 1

i c 2--rlr. Edwin J. Jacob April 11, 1475 CORFIDENjj. i A( The principal investigators would be responsible for expenditures on their particular projects, and would have free=cm to transfer funds among budget categories as required. With mutual consent of the principal investigators involved, funds could be transferred between projects. However, all expe::ditures would be r.:ade in compliance with the applicable state and Univer- sity rules of Colorado or Hawaii, as relevant. The consulting and review panel will be composed of scientists mutually acceptable to the investigators and to Dr. Williarm Gardner. After a period of approximately 18 months, a meeting of the consulting and review panel will be convened to evaluate progress of the projects and to make recoavnendations to the grantors concerning continuation of support. In the case of a reco:%mendation to discontinue a project, funds for phasing out the operations will be continued at least in amount sufficient to meet staff personnel obligations for a period up to an additional six months, depending on the terns of employment. Assu.'aing that obligations have been undertaken to er.,ploy staff through the full second year, the amount of savings from the second year budget that would be made by termination of data collection and analysis after 18 months would be approximately as foliows: Hawaii study -- $82,076 Half sib-twin study --550,737 Animal study - $27,268 If obligations are undertaken only to provide 60-day notice of termination of employment, then additional savings in the amounts of $7,400, $5,000 and $40,000, respectively might be made. If the circumstances are such as to warrant a continuation of data collection and analysis during the phase out period, a negotiated amount not to exceed the budgeted tunount for the next six months, but with a longer time limit for expenditure, will be r..ade available. In thc event of favorable reco.:mendation at the tine of evaluation, research support will be continued, and a second CTR i i N 0263,32

C C 3--mr. Edwin J. Jacob April 11, 1975 CONFIDENTIAL evaluation meeting will be held approximately at the end of 27 months. The purpose of this meeting will be to evaluate progress tnd to make reconmendations regarding funding for the fourth and fifth years of the study. I an anxious to know if the above is an accurate survaary of the principal points of our discussions. Sincerely, VE~ ~ Gerald E. McClearn ~~~~~ ~ CTR HN