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Al .. •,. • .. ; PROPOSED STIIDY BY ALV11N R. FEINSTEI2t K.D. OY TBE NATURAL COVRSE AND POST-THERAP~TlTIC ' GtCTPCOlOi OP' CANCERS 0! TH.. LUNO• LARYNX AND REC?Vit ~•' : '•Dr, ?einstein aolds a faculty'appointment eith ' t ~ ths D.partment of Tnternal• kedicini of the School of Uedicini ^,- ' of Yale VniversitY.. In addition to his Y.D., be holds a ,.:.'•'. . . ~. C. J~:. .• "'Laster of Science degTee in mathdaatics. 8is interest in ''~• ~ aulti-variable anai sis of problens of diseasa has led him . to question publicly the conclusions of those aho claia cigarette s'moking to cause various cancers and other diseases, • Attached is a letter from Dr. Y.instein outlining ' a probabl• need of $5.593 to enable IIi.m to continue a program 1. ~ • . • . . • • . ot ~ lsaarcti on the relationship of cigarett• szoking to the C• clinical course and behavior of cancers of the lung, larynx amd rectuae, Dr, Peinstein's wozs in this connection is at • least in part inspired by Dr. Ian Ztacdonaid's theories of W • '.. biologic pzsdet.rsainism in the field of'cancer therapy, The . , , ... . , . , _ . .. . . i.nportanct of this• aork is in t-so areas (as reli as possibly r` ... . . . . '~ ~.%.. M -, , . . ~ . others), as follorat , . • ... . ~ • . . , . . _ y . ~ ~ ' .. • . .. .J .•I . . • . . . . • .. Sbould the pr.lininarr indications, that thsre is ao cor"relation between cigarette smoScing and , . . •T ~ .. the clinical course of canc.r of the lu•ng or larynx, •- 1 CTR M~~~ 0~~~~-'

I C CUNFIUENIJAL the assertions of cagre,-,~tion and acceler.tion of cancer by saotcing mad• in cart:in of the lawsuits. The point is of particular portinence,in respect of the Statut• of Liaitations. Z. The dsv.lopsiont of t.chninu.s of etulti- variabl• analysis by a aan yhoao training includes both nedicino and nathcmatics should prove valuable in application to otbor dets, as aoll as to his own, tPith roCard to questions of causation. E.J.J. C 0 CTR Mt4 0~8~~~