Council for Tobacco Research
Outline of Topics to Be Discussed at Research Conference to Be Held on November 22 and 23, 1955 [Details on Subjects Needed to Be Discussed at the Research Conference]
Abstract
ILL;MAR
Fields
- Depository Date
- 25 Sep 1995
- Request
- 119
- 120
- Master ID
- Ctrmn00028023-9276
- CTRMN028023-8033 Philip Morris Research Center Smoking and Health Significance of the Report of the Surgeon General's Committee to Philip Morris Incorporated Evaluation Report [Discussion About the Examination of the Report of the Surgeon General's Advisory Committee on Smoking and Health and Their Findings]
- CTRMN028039-8039 the Journal of the Medical Society of New Jersey Vol. Xxxi, No. 2 [Information Regarding Calcreose]
- CTRMN028040-8040 Some Folks Seem to Think You Can Change Quality- [Advertisement for Chesterfield Cigarettes]
- CTRMN028041-8041 No Susceptible Person Need Have Scarlet Fever [Information About the Effectiveness of Scarlet Fever Toxin in the Prevention of Scarlet Fever]
- CTRMN028042-8042 Please Ask US.... The Pennsylvania Medical Journal [Information Regarding Questions One Might Have Regarding the Physiological Effects of Smoking]
- CTRMN028043-8043 Call on US! [Offer of Information Regarding the Effects of Smoking]
- CTRMN028044-8044 the 17th Annual Meeting in Haddon Hall, Atlantic City, June 4,5 and 6, 1940 [Index of the Different Articles in the Magazine]
- CTRMN028045-8045 What Happened When Smokers Changed to Philip Morris? Vol. Xlv, No. 2, 149-154 [Comments Regarding the Wonderful Effects When Smokers Switch to Philip Morris]
- CTRMN028046-8046 the Third Fall Clinic Conference of the Medical Society of New Jersey, in Essex County, November 27 and 28, 1940 See Announcement Page 491 Vol. Xxxvii, No. 10 [Index of Articles Featured in the Journal]
- CTRMN028047-8047 the Journal of the Medical Society of New Jersey Cigarette Differences As Shown on the Rabbit-Eye Test Volume Xxxvil Number 10 [Showing of Experiment Done on Rabbit Eye with Solution From Philip Morris Cigarettes and Solution From Ordinary Cigarettes]
- CTRMN028048-8048 Take No One's Word But Your Own [Comments Regarding Philip Morris' Cigarettes in Relation to Respiratory Problems]
- CTRMN028049-8049 Arizona Medicine Vol. 2, No. 1 Not Only Laboratory Tests But Also... Clinical Tests [Statements That Clinically Prove Philip Morris Cigarettes to Be Definitely and Measurably Less Irritating]
- CTRMN028050-8050 Simple Test Prove Instantly Philip Morris Are Less Irritating [Instructions on How to Confirm for One's Self That Philip Morris Cigarettes Are Less Irritating]
- CTRMN028051-8053 L&M - A Perspective Review [Discussion on the Reduction of Harmful Chemicals in Cigarettes]
- CTRMN028054-8054 Liggett Responds to Press Report on New Tobacco Research Vol. 4, No. 30 [Discussion About Ligget & Meyers Tobacco Company Receiving A U.S. Patent Covering the Development of A Catalytic Process]
- CTRMN028055-8056 N.C. Company 1rst to Admit Tobacco Link to Rat Cancers [Discussion on How Liggett & Meyers Company Is the First Cigarette Maker to Acknowledge That Tobacco Causes Cancer on Lab Animals]
- CTRMN028057-8078 [St]
- CTRMN028079-8109 Challenges in Tobacco Research [Discussion on the History of Tobacco and the Research It Involves]
- CTRMN028150-8222 Topics to Be Discussed at the Research Conference in Durham N.C. On October 22 and 23, 1958 [Lists of Subjects to Be Discussed at Conference]
- CTRMN028223-8223 Sloan - Kettering Contributions [Discussionon About James Bowlings Thoughts on the Sloan - Kettering Contributions]
- CTRMN028224-8227 [Notification of Draft Letter Enclosed in Document]
- CTRMN028228-8240 An Outline of Current and Proposed Quality Control, Development and Research for Beason and Hedges [Discussion on the Program of Quality Control]
- CTRMN028241-8244 [Discussion of Wynder's Findings on the Connection of Cigarette's and Mouse Skin Tumor Incidents]
- CTRMN028245-8284 Xa Scientific History [Objectives of Wynder's Studies]
- CTRMN028285-8287 Corporate Objective: [Objectives for Cigarette Manufacturing]
- CTRMN028288-8302 Statements of Purpose and/or Objectives [Information Regarding Smoking and Tobacco Use and Its Health Effects]
- CTRMN028303-8304 Proposal to Include A Skin Painting Test at Adl to Evaluate the Level of Tumor Promoters in Smoke From Cigarettes Treated with the Catalyst Mixture [Cigarette Modification Test to Be Run with 100 Mice]
- CTRMN028305-8306 Statement on What We Think That We Have Accomplished on Project Xa-5001 [Development of Cigarette System Which Produces Smoke with Reduced Biological Activity]
- CTRMN028307-8308 Brief Comments on A Program to Produce A Low Delivery Filter Cigarette with Flavor [Goal of Reducing Tar Delivery and Identifying Carcinogenic Substances]
- CTRMN028309-8315 Statement of H.H. Rahn to the Executive Committee of the Council for Tobacco Research - J.S.A. [Request to Find Scientific Director]
- CTRMN028316-8326 Ind. Research Committee [Information Regarding Human Behavior As Related to Smoking]
- CTRMN028327-8328 [Description of Cancer Research for Which Support Will Be Needed]
- CTRMN028329-8330 Proposed Study by Alvin R. Feinstein, M.D. Of the Natural Course and Post-Therapeutic Outcome of Cancers of the Lung, Larynx and Rectum [Feinstein's Work Inspired by De. Ian Macdonald's Theories of Biological Predeterminism]
- CTRMN028331-8333 [Recording of Essential Features of Recent Telephone Conversation Concerning the Funding and Operation of Pending Research]
- CTRMN028334-8334 [Request for Support of Planning Grant for Nasopulmonary Research]
- CTRMN028335-8336 [Suggestion of Having Dr. John Vivian Wells As Principal Investigator of Study for Linkage of Certain Gm Genotypes to Chronic Obstructive Disease]
- CTRMN028337-8337 Ctr Special Projects [Description of Research Projects, Researcher]
- CTRMN028338-8340 [Budget to Enable Completion of Volume on Environmental Factors and Causes of Death]
- CTRMN028341-8346 Ctr Special Projects [Description of Research Projects, Researcher]
- CTRMN028347-8352 Ctr Special Projects [Description of Research Projects, Researcher]
- CTRMN028353-8358 Ctr Special Projects [Description of Research Projects, Researcher]
- CTRMN028359-8363 Meeting of General Counsel on December 17, 1965 [St]
- CTRMN028364-8371 Outline for President's Office Presentation Appraisal of the Present & Future Contributions of the Research Department to the Corporation (Tobacco Only) [Four Major Work Areas in Research Department]
- CTRMN028372-8396 Tobacco and Health-R&D Approach Presentation to R&D Committee by Dr. H. Wakeman at Meeting Held in New York Office [Chemistry of Cigarette Smoke]
- CTRMN028397-8398 "Policy Regarding the "Tar Derby"" [Suggestion to Diversify Business at A More Rapid Rate]
- CTRMN028399-8402 Project 0100 - Objective for 1964 [Regarding Development of A Medically Acceptable Cigarette in Light of Present Health Attitude]
- CTRMN028403-8403 All Burley Cigarette [All Smoke Condensates But Burley Cigarette Were Judged to Be Carcinogenic to Mouse Skin Suggestion to Publish Results and Manufacture and Market All-Burley Cigarette]
- CTRMN028404-8406 H. Wakeham Presentation to Philip Morris Board [Brief Description of Five-Year Plan for Research and Development]
- CTRMN028407-8408 "Proposal for the Evaluation of "Project Better" Cigarettes" [Formation of Two All-Tobacco Filler Blend Cigarettes Cost Estimate for Testing]
- CTRMN028409-8409 [Experiments on Catalysts for Work on Cigarette Manufacture]
- CTRMN028410-8411 Statement of F.G. Bock in Buffalo, N.Y. On October 12, 1956 [Concerns Over Statistical Associations of Smoking to Lung and Bladder Cancer]
- CTRMN028412-8413 [Question of Improving and Enlarging the Scope of the Scientific Advisory Board Programs]
- CTRMN028414-8416 Public Relations Report to the Tobacco Industry Research Committee [Role of Public Relations Department and Treatment of Smoking by the Press]
- CTRMN028417-8425 [General Comment on the Current Status of the Tobacco and Health Situation]
- CTRMN028426-8432 [Regarding Current Position of the Committee's Program and Progress, and Course for the Future]
- CTRMN028433-8434 [Discussion of TIRC Program History and Goals]
- CTRMN028435-8436 Source & Use [Record of Amounts Received or Due From Contributors]
- CTRMN028437-8438 [Comments on Report From Jefferson Medical College on the Effect of Cigarette Smoke on Pulmonary Clearance]
- CTRMN028439-8443 Proposed Fields of Research [Present Situation Plans for Future Work]
- CTRMN028444-8445 [Thoughts Concerning Some of the Problems of the Tobacco Industry]
- CTRMN028446-8447 Research Project Suggestions [Possible Projects Including Population Studies to Link Smoking to Mortality, Etc.]
- CTRMN028448-8456 Suggested Guidelines for Industry Committee for the Review of Industry's Overall Independent Scientific Research Effort [Determining Industries Short and Long Term Objectives for Research]
- CTRMN028457-8458 [Individuals of Major Manufacturers That Will Represent Their Companies on the Committee to Study Research Programs Funded by the Industry]
- CTRMN028459-8463 [Overview of the Organizations Contributing to Research Into Tobacco and Health]
- CTRMN028464-8467 Industry Research Committee [Enclosing Copy of Report Submitted During Moss Hearings and Copies of Letter From Janet Brown and Memo From Ed Jacob on Industry Research Efforts]
- CTRMN028468-8469 "Tobacco Industry Sponsored Instructional Project on "Genetics and Environmental Bases of Tobacco Related Behavior."" [Recommendation of A Five-Year Study As A Special Project by the Council of Tobacco Research]
- CTRMN028470-8470 [Opinions Concerning the Ucla Research Effort Supported by Tobacco Companies]
- CTRMN028471-8472 [Projects in Colorado]
- CTRMN028473-8475 C.T.R. Meeting [Discussion of Cash-Flow Analysis Comparing Commitments Vs. Pay-Outs]
- CTRMN028476-8477 [Discovery on New Product Advantages of Ventilated Cigarettes]
- CTRMN028478-8478 Your Letter to Mr. Allen About Tobacco Industries Participation - Phone Call From Dr. Kensler ["Question of "Confidential" and "Classified" Material"]
- CTRMN028479-8485 Summary of Dr. Hocketts Comments [Report of the Surgeon General's Advisory Committee on Smoking and Health]
- CTRMN028486-8486 [Suggestion to Gain Victory One One Front at A Time]
- CTRMN028487-8490 the Roper Proposal [Comments and Suggestions on the Strategy of the Tobacco Industry]
- CTRMN028491-8498 [Comment on Ctr Decision Not to Continue Support for Studies on Smoke Inhalation in Inbred Syrian Hamsters and Plea for Continuation]
- CTRMN028499-8502 [Discussion of Publishing Paper on Smoke Exposure to Hamsters]
- CTRMN028503-8505 Report to Ctr Annual Meeting, Jan 31, 1975 [Discussion of Favorable Press Coverage During the Previous Year]
- CTRMN028506-8509 [Ama Opposition of Proposed Industry-Wide Rules]
- CTRMN028510-8516 Planning [Comments on Priorities of Research]
- CTRMN028517-8519 [Comments Regarding Research Program to Target Consistent Problems in the Industry]
- CTRMN028520-8524 Comments on Ama-Erf Program for Tobacco and Health From the Research Directors of the Supporting Companies [Scientific Representatives Attending the Ama-Erf Presentations Say Half the Program Was Not Relevant to Smoking]
- CTRMN028525-8539 Remarks by Ernie C. Clements, President Annual Meeting, the Tobacco Institute, Inc. [Information Regarding Division of Responsibility and Statement of Objectives]
- CTRMN028540-8543 [Mention of Tim's Impressions of the New Offices]
- CTRMN028544-8545 [Talks with Dr. Huber, Dr. Rabkin and Dave Hardy Concerning the Harvard Project]
- CTRMN028546-8549 [Suggestion That Harvard Proposal Be Accepted in Principal]
- CTRMN028550-8551 [Status of Special Project 98]
- CTRMN028552-8554 the Gallop Poll Public Opinion Volume Two 1949-1958 [Questions on A Variety of Topics]
- CTRMN028555-8602 Doctors and Smoking (III) Their Smoking Habits, Their Advice to Patients on Smoking, and Their Views on the Correlation Between Cigarette Smoking and Lung Cancer and on Research Conducted Thereon [Number of Non-Smokers Increasing Largest Percentage of Quitters Is Physicians]
- CTRMN028603-8608 the Gallup Poll Public Opinion Volume Two 1949-1958 [Questions on A Variety of Topics]
- CTRMN028609-8611 the Gallup Poll Public Opinion Volume Two 1949-1958 [Questions on A Variety of Topics]
- CTRMN028612-8660 Doctors and Smoking (IV) Their Smoking Habits, Their Advice to Patients on Smoking, and Their Views on the Correlation Between Cigarette Smoking and Lung Cancer and on Research Conducted Thereon [Smoking Has Decreased Significantly Among Physicians From March 1957 to August 1959 and Among Those Who Do Smoke, Most Only Smoke Cigarettes]
- CTRMN028661-8665 Research Summary [Method and Consensus of Results From 4 Presearch Sessions]
- CTRMN028666-8667 1950-1974 Per Capita Cigarette Consumption (18 and Over) Gross Cigarette Consumption (Billions) [Despite Periodic Drops, Cigarette Consumption Has Risen Steadily From 1950-1974]
- CTRMN028668-8689 Verbatim Transcripts of Radio Broadcasts Photographic Transcripts of Television Broadcasts ["Transcript of Arthur Godfrey and the "Chesterfield Show""]
- CTRMN028690-8690 [Invitation to Visit Laboratory and Examine Sections]
- CTRMN028691-8701 [Thank You for Invite Dr. Sommers Out of Town Until June 29]
- CTRMN028702-8716 Proposals for Discussions at July 9 Meeting [Transmittal of Proposals to Use As A Guide for Public Relations Part of Agenda]
- CTRMN028717-8723 Distribution of Tobacco and Health and Tobacco News [Publications to Be Sent to Subcommittee and Public Relations Committee]
- CTRMN028724-8747 Public Relations and Budget Proposals [Public Relations Program Designed to Meet the Industry's Challenges in Health and Create Understanding of Issues]
- CTRMN028748A-8751 Scientists Report...Human Virus Induces Animal Lung Cancers [Cancer Responsible for Respiratory Disorders]
- CTRMN028748B-8751 Primary Lung Cancers Found in Study of Nuns [Report Shows Cancer Can Occur in Women with Little or No Smoking History]
- CTRMN028748C-8751 New Research Work Raises Questions About Origins, Types of Lung Cancer [Find Most Cancers Start in Periphery of Bronchial Tree, Not in Main Bronchi]
- CTRMN028748D-8751 New Research Work Raises Questions About Origins, Types of Lung Cancer [Study Shows Decline in Epidermal Cancer Frequency in Males]
- CTRMN028748E-8751 Study of 163 U.S. Areas Shows...Lung Cancer Death Rate Vary Widely [Sharp Differences Exist Even in Similar Size Cities and Similar Geographic Areas]
- CTRMN028748F-8749 Chest Specialist Says...Basic Cancer Data Being Obscured [Professor Calls for Renewal of Investigation Into Association of Smoking and Lung Cancer]
- CTRMN028748G-8749 Study Questions Accuracy of Death Certificates [Certificates Are Unreliable to Use As An Indication of Incidence of Cancer]
- CTRMN028748H-8750 Report by Little Cites New Tests, Human Type Tumors in Animals [Means Are at Hand to Design Tests to Evaluate Influence of Internal and External Factors on Inducing Cancer in Animals]
- CTRMN028748I-8750 Study Finds Cancers Arise in Lung Scars [Close Relationship Exists Between Scars and Development of Cancer]
- CTRMN028748J-8751 ""Competing Risks"...Diseases Have More Than One Cause" [Consensus Is All Disorders Have More Than A Single Cause]
- CTRMN028752A-8752 Virus Causes Lung Cancer in Animals [Ordinary Viruses May Play A Contributing Part in Human Cancer]
- CTRMN028752B-8752 Air Pollution Blamed for Lung Cancer [Report by Government Physician Regarding Cancer Causes]
- CTRMN028752C-8752 Cigarette Makers New Survey Disputes Tobacco-Cancer Link [Cigarette Factory Employees, Who Smoke Nearly Twice the Average, Live Longer and Have Less Incidences of Cancer]
- CTRMN028753A-8753 Finnish Doctor Challenges Cigaret-Heart Ill Link [Questions of Cholesterol Levels Arise]
- CTRMN028753B-8753 Lung Cancer Linked to Auto Exhaust [Political Steps Should Be Taken Against Air Pollution]
- CTRMN028753C-8753 Japanese Research Finds No Link Between Lung Cancer, Cigarettes [Scientists Also Rule Out Exhaust Fumes As A Cause of Cancer]
- CTRMN028754-8760 Heavy Smokers with Low Mortality A 14 1/4-Year Test of the Cigarette Hypothesis of Lung Cancer Causation Industrial Medicine and Surgery, 31.3, 115-120 [St Paper Extends Mortality Rates of Cigarette Division Employees of the American Tobacco Company]
- CTRMN028761-8785 TI Annual Meeting Remarks by R.W. Darrow [Suggestion of Hill and Knowlton to Continue, on A Reduced Budget Proposal, the Regular Public Relations Activities That Have Proved Helpful in the Past]
- CTRMN028786-8789 Tobacco and Health Research Procedural Memo [Instructions on Writing and Production of Publication]
- CTRMN028790-8796 [Comments on Suggested Guidelines for the Industry Committee on Scientific Research]
- CTRMN028797-8797 [Meeting with Burton Marstellar Leads to Decision to Present Draft Statement to Full Communications Committee]
- CTRMN028798-8798 A Frank Statement to Cigarette Smokers [Statement of Recent Reports on Tobacco]
- CTRMN028799-8800 Tobacco Research Fund Raised to $1,500,000 [Support Will Enable Effort to Fill Gaps in Scientific Knowledge]
- CTRMN028801-8801 Cigaret Theory of Cancer Hit [Blaming Lung Cancer on Smoking Is Retarding Research Into Actual Cause]
- CTRMN028802-8804 Three Scientists Raise Questions About Cigarette-Cancer Theory [Scientist Claims Causal Relationship of Cigarette Smoking to Lung Cancer Is Unproved]
- CTRMN028805-8805 Cigaret Theory of Cancer Hit [Blaming Lung Cancer on Smoking Is Retarding Research Into Actual Cause]
- CTRMN028806-8902 Bird-I A Study of the Quit-Smoking Campaign in Greenfield, Iowa, in Conjunction with the Movie, Cold Turkey [55% of Smokers Who Quit Cold Turkey Gave Up Smoking for at Least A Month and 28.3% of Them Were Still Non-Smokers Eight Months Later]
- CTRMN028903-8905 [Recommendations for Industry Research Prepared Last Year]
- CTRMN028906-8910 [Thoughts on Things That Need to Be Done]
- CTRMN028911-8913 Confidential Report Tobacco Research Committee Meeting [St]
- CTRMN028914-8920 Remarks by Earle C. Clements, Prepared for the Board of Directors Meeting at the Spring Meeting of the Tobacco Institute [Discussion of Evaluation of Strengths and Weaknesses of Tobacco Institute]
- CTRMN028921-8921 Industry Research Liasion Committee Meeting, May 15, 1975 [Discussion of Insufficient Space for Some Laboratory Aspects of Harvard Project]
- CTRMN028922-9276 Dr Little Comments on January Applications [St]
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..' ten eh relati.ely l.rie perosnta`s of non-saokera lo tb oanosr
'' _'.a,-.osec not sooet`aes a ratl-er
..; :.' acoint ssok.d a:.d uawlly aery oea6er or
f:e-. ,--:r :.1 tory of t-, subJsota.
::.e c:1sr type of atAy vhieh tAs bsa:: aada 1s tne prospective er
: or:ard lookln: t1Y.. In this type of study iarda Rouys of people are
intereler.d as to their ssoticg b+blts aa1 other yertiaaot SoSoraatlor..
Ttelr sortality data is tbao atudl.Q to dataraloe the rvlAtioo batveen cause
ot deatD and asoklog babits. ?roay.etiv slsdl.s of thic :,atur" ar. aose-
_a.
:.r cajare a larea resldual artor and evin though tna statlstioal
'.. .^ sed s..m to gi. s1:niflcant results twre ls
-r t '.:.e cr.fiae.,ea :Smlta of t:.e res.A ts. Otter erltleisms
.. ..:r :y;e Df study are t:e yo.elbility of con-oDject!vSty
vhat fr..r of objaotioaa ait 11as thaa tbe r.trosy.otl. atudi.s. H.vw.ar,
t hs al l Qi tT f th r. s.1 t s frw aip t7ps sf rtu0.f oy bo atri ou aly at f.o t ed ~
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bf thr loterrl.v taobaiQws ss.e6. Ooo of the rjor Qls&d.antites to this
kioQ of etodf Is tb+ rslatiall loa>t tise r+Qn1r+Q to pt results aM t.bs
eooooaitaDt difTloaltf eoouqte"d 1D k.e.Dias track of ttv ctLanges ia
place of resid.noe, ooovyatioo and saokios bablta of tba subj.ets.
Th results of a prospective studJ of 24,389 oa1e physiolans,
ttirty-fie years old and ol.d.r, 10 the Uait.d Lio.adoc. and results to date
ot a study by tbe A.erloao Caaosr Society of 187,766 a.1ea, SO y.ars old
and older, in the Un:ted States se.m to support the contentloc tn.t t..ere
1s an 1ncr.ased rlst ;f lun1 eaaoer aaont nea.y saokira.
Taken by tr.emsel.ss t:..a studl.s tend to Indlct sZoYlcL.; as a
n+ajor ca.r.e of 1ung cancer. noveeer, certali laci of qwntltatlve a;-.ece.;t
Di:ve:n ;r.e arlous studies, rural-urbaa cancer rate ratlos acd ::e
stb.ence n.' decreas:na i..a:e-female ea:,cer rat ratio te:.d tc ln.lci.:e
: at at...r .'b : :ori 3ay ~ ry vell De tr. sa)or =nes.
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CR nc.r J,n j.aDoratory "mis
-:r :.er- 'Sfty years att.spts h+ve basn aadi to produoe oancsrous
-_ F ter.: anlr.r;s by aub)setl<<s thsn to dlff.rtnt trsdtasets
e. )erlved f:oa tobacco. :Lsse anlaal xpiriasnts rer flrat
vrre b..ng aaos that the use of tobacco was r-slat.d to
- ' 1a, t~:wue, routti .nd larynz ivnd aa.e ba.n carrl.d on In
: r. : r.cr.:ers 1n reosnt years. 5vse of tne substances vt.iet :aee D.an
~rC rc .ar1 uc tobacco =tracts, tars prod.uoed 1n the destr.ctl+s
c1F::::a:ion of tobacco, and ariously tryat.d saoLa residues. bos,e
nsjccessfu; attempta were a+ad.e to indoos lung oao4.r C7 allovin: nice to
:r.hale tobacco uoke wbioh waa lntrodncd 1Dto thsir oat.s.
C'nt11 tse work of yyodar and Orahaa was ptiblish.d ther. Aad b.aa
no genera117 ajospted prodaetioa of e.anesr la laboretor7 an.lmals E7 " of
these tr+ataenta. AltboW as1 o+oaalotrl tuaor was produo.Q thay wsr
usua ay oonaider.d to b* etthar p.pillosas (ao^ -- - srovs tu.ors) oT
spontan.ous eanosrs in susssptibl st»ina of nisals.
by palntltg th* aSa.sd backs of laborator7 aioe with an ao.toos
euspen.lon of ol:ar.tte saoks r.slaue, YyDAar and Oranaa wer able to
produoe ca_rolnosas ln 4-4% of the anla;ls. In taras of body welght and
fractlon of norail llfstia., the doss 8110 Lad lso,gtn of treat.ent of thea.
slce w.re pro:abl7 sQul+alsnt to the saoL'ne of about 7 cartons of clbaret:ea
a day for !-0 years. This eo.pletely u.nr.allstic doas vould b absurd for
ardlnary toztoolo;loal studies. rioree.r, tr.er are theoretioal r.as:ne Y J
t~.1s terrlf1oa11y larQe doss would not 1n.a:ldats the ezpsrissnt. ':.1s
w111 be dlscusaed further :n the fo11ov1nQ s.otlons.
3. Giovr., Carclno sns
:n 1939 aA. }i. noffo reported t:,at he found tre Yncwr c.rc:noLer,
r-ns :r. trs dist111at1en ,)roducts of tooeceo tar. i%c"c ~ e
t.~ :'l1u::~n on t-:e basis of ultra.lulat and fl.:orescsr.t spcc:ra.
a:;e-;..s :'~ repeat noffo'a wort were unauccesaful.
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'n and 19tL Lef.alna, I,l.ord and Cardon, a~ Lladaq and
o.1ng founP in tars oollect.d froa DurnlnQ
r, or ci,;arettoa. Al.ord and Casdon Durned olbarette
cc ;. _ elaaa tu:e and condene.d t"e produot of oomDustlon.
!'er:-e d ci,*aret:e p4pper and used the aame type apparatus.
iOk e~ a. -o:yr e tc.er reFlac.d t1e toDaee~ to oigarettea .Ste ahredd.d
c:_. .. ;.arr rr used atan9.rd eliarettes. Tnese 'paper' cliarvttea and `
r r-b.lar c:,; rattas rere amoked on a amokind darioe ai1d the taoke was
;D^enaed. 'ce ldaatification in eacn oaee vaa frca ultra.lolet and
!y.ioreecenoe spectra. TL apeotra.l our..a of Llnd.ey and Cooper hato not
De,.n puellaned and tne cur..a of Lefaain and of Llrord ar,d Cardan ara not
u:aaiDlsnou.. TLarm ia no publ.ishal ..idana of atyooe ba.inj a.etuaW
a.paratod this ooaponrd In ita par fora froo oi.gar.tto aaok.s r.aidnea.
~. ~
The appar+ntly W1d.. ays.aQ imraar of luat oano.r Snold.ow
1
eti..as to point to ao." aan wtiv+ &g*at or agent rnioL vould .zbiIlit the
fa$owrlag propstlaa:
a. SosetA.ing inbalAd into th. lussa.
b. Sos.tGing .rEioh a gr.at rny people art arpos.d to In the Ualted
Stat.s, Ln:Lnd and otWr parto of the world.
o. So.I to vbieD peopl have Dean Sneraaeiagl.y o:poaed to In
th last aetrral d.cadea.
6. SoaettanQ to aAleh aore axn than voaen ara as?oaed.
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a. So..tr.ind to ve1cL
drell!ra.
urban dvllera ara nore ezooeed to ttun ru.ral
Cn tl.e basis of the above properties tr.e fo::w:r.e f..tore .:u:d
De ievad with suapioicn.
a. Co-Duatlon ~eea from coal and o11 furnacea.
b. *.xC.au.t Cseee fro internal conruetion en,;ines.
c. Asphalt dust froa paed roala ar.d otreeta.
d. :"1 . rtte amo'e1na.
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VTR Hf44 0~'B I 16
- 6 .:
;'r.e ;,ubllah.d at.tlatlcal atud].s tand to ledist oidar.tts ssok.i.r
*:o-over, tr.e rura1/uru-. ratio and ths laek of a tios trsnd in
:r S.,c' e "^.csre cn tne siln of laboratory aniuls
- C. .' a c.wr. carclnove,i C.r.e beon rYport.G Sn tacL.
,r.je iytc: :ay,r prcducea surr .plderul :el:.. :'nder norcal c:rc,_=s:.. .<<
10 -eAr-e.. For lnota:.c., v^en saall portions af tr.e akln art r-- e
adult nrganl.a naa Lesn foraed.
Tr d pacttl of tlasus tc rrov is no: lost vren tne ac.:: Rta;e
tr .'urtrer e-rortr. of the tlasusa slo. dovn and ultlistely ce.e.e nd tr.c
oalltd dAfferant/a U on. Aa tns saxlaua dadree of dlffer.nt:atlon 1s at:alned,
tis* tLat tRS.s tlssues ars ds..loplnQ lntc pn,vaioal sntiti.a tney ar+
also d.vslopiag sp.oiall:ed pr4alolo;lcal function. TCls procsss of
ds.lopltq dlvergs^t ptusloal form and p*siolodlcal funct1on ls often
d..elop lnto di.tlngulsLabla .ntltlas and art oallsd tlsauea. At tte aaa
Probabl,f the sost sar.orri nar~ and sost lntrioats pLanoasc,on in
ru tur+ Is tbs ordarly ds.slopssat of tbe li.ing snltlosllalar orgaaisa.
Tms dr+.loposnt vhlob starts froa a ala.tla f.rt111sad *" oell proo..da
tdroagb raaJ os:,l dS.iuoaa to 'baild cD prl.sdtl.e gsrou'p of oslls with
a.rfiag a].strlbutloo, app.araaes,aod fnnotion+l pot.ntialitl. Yltfl
contiausd growth of aob grou,p of oslls, their saparats o~ar.otsriatio.
dlargs or* and aocv froa oac4 otDer and beooaH inor.asingl.y aocantuat.Q
In each group. %M ss groups of oslls, ritb oontlnued o.ll dlrlslon,
discuss brlsfly just wt6at a oanoar is. 2his will be don. In tbe n.zt few
paragrapha.
and tu
e1tc'_ '.-.tuc:lon cf sancer and ylolotilcal te
.. Yhat 11 A anosrl
before procs.ding further lt volld p.rtupo bs a good ld+a to
' '4 1
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ti' a; s s:_e DreaLdov:. cf tlssue vlth a auDs.quent r.gan.rction Ly
:ae radeneratlcn rsachea the :wzl.um allovaDle
:.a- :terie:le r.f tne rdult erianlsa and t:..n esasas, TGa
::a:::, .' a.; t1.c . la usually confined vitGln dafln_te 11:1ts
-::r ~:c:. are exerted oy ::.e oreanlaa. From the Lcglnnlnd of call
:::^ .,.: of ::.e f.rtll:zed ed to :r.e attaln.ent of tne adult
s:,d ero~ ::. o' eac:. tlssue Ss eoordiut.d v1tC
:...: o' e.rr± ot:,er tlas'is. Lnd t..ls eoorClwtlon 1. a.ytr.ntly yintalr,ed
,..r:j;nou: t:e 3reatar part of tne life sDan of tn or:anlsa. YStE sold
a;e' tne rcg.nerati.e c.apaoltl.s of tha tissues are Qad:+ally c1a1n1sL.d
at rates vtilca s+ay De dlffer+ot for dlffarsot tissu.s.
Th nors+al zistsooe of tDa awltiosllu1ar orgsnisa is, tharafora,
att.a1n.d by tD suDordination of tha aapaolty ot the tissaes for growth
to tha .aint.oaao and Dal.n.a of t.La orpnia as a vLOla and to tha
indl.ldual parts. Oe,aasiosi117" a sisin s+a.F trov DaFond the normal llalts
oT tDe orpnisa, Lut aa loas as !t rwalns ondar tb e,odtrol of ths
orSaalas it asuallF gTOVa r.l.ti.ely slovly. It .ay ultlrataly r+turo to
Its nor+al slie or St .ay reach a yoimt of L+.laDes ard not Snorease further
Sn slt.. Thsse t.talgm, oootroll.d or.rgrovtLe of tissue ar" oot noroally
fatal to the or6anls as a vhol.. If they yt.ye1ca11y yuaL adalost sone
vital struetures vLleh ars oonflned in ae unyleldiag space, sucr. aa the
slull, d.atn aay result from ..c:Ar,lcal ear.s alone: TLe :enera: ;..tys:cal
aDDearano of the eells and the ;r,~ alclo~lul functions c: t. sae C.r.lb-n
tueors are very a1a11.r to th tlssues fros vLict :ne) or1.1i,e:e.
Ihere Is another klnd of tl.sue srn.;G v:.i.. to aom ea:eu: is
free fro- ccntrol of tt-s ::sanlac. Tn.ie ti;)e -~f Lrcvt_ is Crr .e^:ly ~r-
_.c.lted a-A cortlnuous; lt yroee.ds at a rA:e f-r 1n ice:a : r -. t
Tt crocred: vltr.out ceneld.rs;l:n for nelet,Lor:% tlssL:es v;.lc: It
crnpr.rel.ely :n.adre, destroya, anri retlicee. It 1e :aoe;e,:cent :f
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t..r ~y i'°. t~N 02 6116
uf ttsord.niaa s a rhole and ultlutelj
;.i.ypical app-.rancs of thsse 6rotGe ary con.ld,
f ::,e Ls.eloped tlssua 'roc, vlileA tbsy beian;
AME
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CTR MA 0~261 1 C
-. 'ive .'cres cf t:.ese tlUsuss. Tbe eall patterr, of
r . 'r~c~ey c.sauerrd, tej ei k eratad, a n d -j rw.lffere.,t:atad.
e- sr ~:: r.dr: e c ccordlrutlon cf tre effected t:ssue vaa
.-..tr.. .-.:t, rt^or_al tipe cf ;ro.t' Is t:te
r-. - cF.!- ~:erltlc f t..e
.~nrnoaeno^ v:-ac. Ss
:,-t: c a-e at cancers.
o.novn cs cancer.
*,he
2. C.rc^.c: e'.2c 5ubatancet.
'ne observation Sn 1n5, by Perciral Potts, ot tre hiel, lnoidence
of cancer of the ecrotui aaong oh.taoel eraps an4 the later cbser.atlon of
the L]sl. incldeics of stin oaaoer aaoag the eoal ta.r d1at111a:1cn voriara
in tt.e 19tG century 1.n to aaoj efforts to prdduos oancsr eryeri~.nta:i~.
Stls sffort ras not wd.s solalj to saaluate tbe d,a.aeers of SAduatrial
Latards but vas ooasidered of utaost iaportancs froa a th.orstlc.l point
of ier. It had not then been astsb_lahad tr.at oanoer could be prod.uo.d
by a knovn cb..iul subst..hoe. llu.ierous Sn..eti4ators .-ere un.uooeeaful
for acu years in thsir efforts to produce oa:osr Sa er,»r:eental anioals
ty eoal tar products. Finally Sa 1915 two Japanees vorkera report.d tt.e
successful production of oancers or the ears cf rabtlts by e:tendeG a;,;11.0-
tlons cf coal tar. hfter deaonstr.tlr.e t:e carclno,~enlo property of coal
tar tr- nezt lojleal stap vat to attezpt Ssola:ion of tre substance cr
oubstanoes vr.1c[: was r+epor,slble fer t:ls property. K.nnavay, Coox, =::e_er
tnd o nrs, 1n Londcn, saparat.d a aaall qua:tity of a yeilov crysta:::ne
o-:er'.A1 frr sbout twc :ons c.' coal tar. '-ney lcter yro.ed t,'s ye::c.
-:~r'til te ce :, -Je:.:;yrene. _rene /a a po:e:- t carc_ o rr.
f:r t e.ln of a 6ouF.. +'.aee lnndon rorkers used t',e Carc:tcper.:c
, ; (f :rc r~Cet..nce w. ic: tre) to ~r.t as a eind cf :._1~. --.r :. c
