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1 Dr. C. C. Little - 2 - August 19, 1971 / our major users of fractions, is now held up for lack of material and is restive to get on. He and I at least discussed adding the sarf frae the discontinued Agriculture laboratory to hi• contract, since this individual is said to be both experienced and responsiv.. i think Dr. Huebner is headed for .hole animal testing if possible and for sovs sort of product modification end point. This involves rather quantum iump extrapolations fram fibsoblasts to lung epitheliam and from tissue cultures to vhole aoimals. Onoo wonders if a very expensive program to relate C-type viruses (not present so far as is known in human cancers, includin9 the publicis.d Taxas disaovary, which turned out to be a aouse virus contaminant according to Dr. suebner) and o.rtain condensate fractions in eo.bined carcinogeeesis really contributes to solve the human lung cancer problem. Dr. Huebner gets irritated when questioned, suggesting a little insecurity on this matter, at least to my mind. Why get into another analoque of skin painting? Drs. ltockett and lurst are planning a trip to England early in S.ptaaber, to see some special (not national) laboratories in England turned up by Dr. Loosli. Sr,,,r.~ Special matters: No further progress on an inbalation carcino- qenosi ^program is evident. Contract subcomittees from SAn are now assigned. I an afraid the review is not going to be sufficiently touah-minded. We aay need ad hoc qroups of outside consultants to give us what is r.aed.d to reduce, phase out or cancel certain contracts. othervise they run on indefinitely. Mr. Yeaman, Brown a'illiamson, wants rlore frequent, more detailed and more formal verbal progress reports on each contract and grant. i have aqreed tentatively that Dr. Aodcett and I could give a two-day session quarterly if need be. Coronary disease espssis»ntal research proposals are finally o>mai:q in for ooasid.ration at the next 3AS neetinq. We ars offered at least one priaate model on a pr.liainary basis. Dr. sar9er's qroup also have a priaata model to propose. Probably if ve take these an and continue or expand Dr. Yvsbaar's ooatraot (rather than reducing it) there will not be saouqh bndq.t to cover other things. i am ooasoious of aot doLq a very good )ob for C3'1t b.oause of iasrtfiodeat tias aad attention to sp.ed. TNs hospital probls.s ars also greater than e..r. llor ssaob longer it is possible and desirable for s,s to omatiaas a. 1lssearah Ddraotos I do.'t lnaov# but not long. All b.st misA.s# siaosrrlTo fb.ldoe C. 3c.rrs , N. D. ta.asab Director 90 oolt THIS DOCUMENT SJCIECT TU oo, tR11 CONFIDENTtALITY AGREEMIENT. CTR HN 01493-4

A , `s Augti:st 19, 1971 Dr. C. C. Little R.t.D. #1 susvorth, Maine osos Dear poctor Littlas / Herewith is a delayed report of what has been happeninq in Jure, July and this part of Auqust. I have thought of bringing you up to dete many tiass, but sufficient tia+e and enervy have not been available. General 'atters: The search for a successor Scientific Director has made no qsnuis» progress. Dr. Felix was extensively reviewed and iaterviswd. se e.idently hopes to oontinus in his present job boyood the, srndatory retiresnt age and it is poesibl. the univ.rsity may change the rules in his oa.e. Dr. Gardner of New Haven is interested but heavily cosaitted, since he is president of two societies this year, and has teachinq responsibilities. I hope and ast told there is a reasonable chance ho may be willing to come oA as a consultant or marter of SAe or both for a year or so to see how he likes it. This would not preclude a continuinc_ search meanwhile. My belief is that since we have failed hitherto in qsttiany someone to pull up roots, move to New York and take over a nsw fult-time )ob, the approach to candidates vould s+ore likely succeed if they wro encouraged to participati in so** part• ':.-%e activity Like consult&-nt first. Generally each individual has to get over a suspicion about C'!'1t's heinesty and self-int.rest which he hears from colleaquas before makinq a cvs.itssant. we are still at least two people short in staff po.itions, but Tom is trying the ledsration Job Prosp.ot book for candidates. Additfom to our personnel are so ovsrdw.that they asr camplicatinq a difficult s+W,torinq problem. Our aaahine testing proqrat has essentially concluded. U newrsd very slor to s., but I supposa the siachines on order can now be prIadaso6. TIw PLeehp Comitts+ met Jaly 2=r+d, and among ot2e r qor.nral aattbrs ocasid.rad who ia to prodaos ooodsmata fractions. This "11 bo disons.b at the S71B ssstisq, ostensibly with cost estimates pro.id.6 by Dr. Kreisbsr. We ba" s."aral probl.r h.r.. oam is that Mr. Pass is unoon.iaced ve should oositiane to .Waad researah in condensate fracticds. Another is that it w ohanqe from oos.eradal aiqarottsr to reference ciqarsttsso the ooadensate and tractioos ar* thereby alar.d. A third is that Dr. Rnsbnsar, rbo is ons of THIS DOCUMENT SUS!ECT TO CONFIDENTIALITY AGREEfvIENi. C T , HN 0 14 93 3