Tobacco Documents Online

s rAk LETTERS TO TEiE EDITOR 3-17-71 Page A?.6 ?H1S DOCUMENT SUBJECT TO OOIiFlDENTIAIlTY AGREEMENT. ~ ~r ic c, ~t~ i• . ~ ~r-~ :.•~ fs`i.:.~ [7A n.~.~. lait~+ d E ~0 t! il t•cs i:-a v: tr t :J ! Tobacco l;Isti:u:e Replies SIR: Recently you publisF.ad a ler.gthy lett^r from thrce officials, i::cl;'dia; the ores: =n', of the 11ec,i'al Sxiety of the Di.~uict of Colum*o'•::. pttackizq a rccc ; rcpart by Coluln :ist J::mes J. 1:E.patrici: ow the rc:o- rious "smcking dc:;" rCSe3rch of 15ii>. Mr. Kilpatrick can !:a:rr:le his a•..n of ccuraa• tvt :rc car: ot pcr:•:it }c_r rcad^rs to I•c r.^.isgt:kI.cd ; the a_sertions of the Il:ree do;;o:s v:!:o:e lea,!r Y.1i published. Certain of th:9: ^d Q7f ~'n. incluoing tne:r statcrncr.; th• t t:: "1 t: ^"_: t~ ~: ~ c~= < t.port v.as pub!isacd a•'ear agc. "it I.d luag bc: -, st'.p(•ctcd thzt smo:ir; did hzve a rcia:i:ashjp :4 canccr," Lut "no proof h.d . It zpp:ars, t', .::•e• cr. that In sc :rz:; resp,cts the three do:t4tY hat•e be:n se:ioas!y rais:ed by t:::i: solrfce4 of In.ArrAatioA. The cllron4!ogy 4f the "siros:::; d'ves" cll:so::e 1.' signi°icaet. For more ttian tao ;:c•ars. usir•- sornt tnrce•q'iariers of a mil'ion doilas .>• t:ie Amtrican ('a::c'rr Soci::;• z~d th^ l'!••:rp:.i :;d:airi-!ra- ti;r, researchers had a n•o::p of oaa":_ dr.;, ci,,arc;l.:s t!l:ot.,-h ho!cs c.::n t;:cir I'.Cyc•rtefl i!:cIP 1'tn'!:::ZS 6n CCJ[ua.'y 5, :970, tn: 5.'ICna 'S 1;~t 5-i9 r~r4:!cd thci; find;ags t,> an n^:e::can Ca::==: ar:d to thc p::::!ic :; a lar::: n:..: cn..i :.,...r it: :i.. ~ti 2!( :: -~cC iCla ~O:Ci al ~ :'c Then t~^ "acs+• Jrit:r•t:_l of rc- f::=:d :o p....!i:~, :c=ir b^caus ~ ...c~ ..:i cc5t•crcd tlarC: first to :!'C G:.:S TFen, i:, J':::^, thc rescarc!x:s d:i!t'erei:r:s•ver- sions of th•ar -cpcrt to t`c .~:•iA co: :'c-".ca in Chicaco. Tt:er. the "Juara:.l of t:^. An>cri:an :•:ra::al Associa- tion" rc;e::cd t':l-ir re;)•::a for publicL:!o:±. Then the a•a:hors su:;:nit:cd ne•r: re~?::s to "Ar- chi~•cs of f:cviror..^ _r.:at i;e4ith" c•n ahc+:e editorial bclyd, :,s s:ertes. 7ha e•iito: ef that ;^urnal c4: : e lcd s r,.•:aing in Jul.y Vci'h the authors a;-.1 a %e:,:inrrr empia':ed by a Pi:i,ad;!p~: d:ug co^ pan}' ra it c firm's heldauarter_, to ~.rork oat er.ou;a c;l:.:.?ea i:. t:ie xianu- scrips to ::a;e tbc:n suit ,b!: :or pub'.:=ador Tec final ve:•sio~s of t` a papers a;; :arz-; in Pra,: in Dcce+nb: r. Contrary to the state-ent by the thrct Cr:ars t1:3t "these tl•a; no chan;e in t!te scien:itic cc•^'°it of t} e paws %:fiich would i:a.e ciffered in a.y wafro:r. t^e initial t•CesiOn, t.here Kere, i.^i f:,ct, nt::r..ro" ae:: xa;or chan;,.s. Onc of these u•as dc!ctici• in the Dc_cmb_r reri+on, of a state~ F.u:pxe of :i'o e\pcrinlr.-it in Fen:l::y ve;slon-'`to a-,~rt in v:h_:i:c: srno::i: ; c!: i:c:tes for t-wo y^nrs cr ica,t•r wii! p:cacce lur:; j:an•::: in d.:C7.'> Co:dr~:y to t.-.c S:-;c, .rt by thc• ,.:rca L:•: :ors. !!ic pa'h:+loo:sts v:!'n :c•i thi; rc,.n.:.:ca t.:c)re 1._t F cL:,,.~ry did not all cv: cti; :n c:.c fil: ':,. Con: ;y 'o , by .h.. _ r. . I:.. t; ::r uc:. at a... s: i:n he at: in \c•:• 6.1 r~:•t .:ic oJ r:crt'rri> - lie Ni1Td t/~:5 r".rly_. i , "Am Inl4:,:it`:1 of )o:tr iril'It]!lar: fOr T1:c t', ynur ... b:a,I_ exr:rin:cntll mat^riat. ~c ble also to fc:r:it o:i-cr ;o %r• :- slidcs a-td prvt4col si :c. as rc-carch dircc:ci C:=. recicw ty mc ais :: n;i;;h: be r•,nsidcrccd cinsco. ua return . v•ou!d ap?rcci: tc furt:;c: c;,;>,,:,uri'.y fo: discussio;l.'- Tcvcr Itcspol:dcct The rc,^:,rchcrs na•: er rc=; on•:c:! tn hirn. The thr.c doc;nrs :ay th'_ a!::iors tnission to re;r..ct the paper'• freal ti:r American Mcdic•al so t!1: :o,tX. ~ .s:i t. eluwh.ere. Thisisc^rt2:r.ly Ti:- :att i: ...: t, auth~rs r,:eit to ar,othcr FuL1i~:.t~o l 1':tit "-•r :t. •r . Sn_rlpt°_. rt;'1SIf.~ to ar•J Gc:.l iP"' :„ t^;!- W 7 whom J:.`i.1 t*d ;;uoroittcd t',e paae,s for rr..: . The three do•:t~rs s:ntcd cc.:e2:'° tt•:1; the :'•;~_Cc> Institute r!(,~.•< r.at .^:CCI:: Iil'.i CXjlci i^.!:;it, ?:i : T?•I. 3s any p:c~f th3t ci';arettc come ill. As r,lost e::pcrts in the fic!d*arc' a;t rr. :xicntists have l>°en attr:n?t;r~ to prodece in aNmata for taree decades :- r::oro r:6.4 c; ci~arette s;.lo::e. and have : ilci. tt,is \atic:lal Czr.ccr Ini::t;:cc's 'aa!.a_e foct:sith considcr :bic funas ard ict ;i- ,~ :- :e: ar.im: I c~;•e-ir.: ^tat na rlc:!lcds c'n •!d r-r•a- ble ar.a•.:; cs b:n.. t!:c ::rco c'i.: urs h::':e cx:):`: lict th.-t dLtC'_Se; S.!i s!r._clc ;rczt•a: c.:.:3e :or reo•t~ct 0 tfCAl a: t'Si -" ith ti•^_ Na:' r lC.. ''l.. . -A'!'!C!i s-~iCi -i: a'C!lr:2::a it- nla: dna't kr.. t':e ca, -,. n^.`yi i}'Cir: o[ f::Jri iO,C?t?~li5h ai)OCt sn:0~ali~ ar.d f:atCil. in a q:::cksancl of itLt: :ical o;= • t: ._-'t. th^se "rr;> h: lie;cd it cc,i':t- A'!th the ciuiC? of thr0? of :e'I2r~est ~•4~:'..ta-''..,1:';I riisicg a:sncic!lor:, ir+ th•: co:n.r~•. in the a: c a,; canccr, h^art anti di;e; _T;. The toL_cca it:.:•istry itseli re:^ `ns the ;ar;;;t contriba'o: tn ;~c rEie~tcit Iil ing and heai:h-,:ri C'.t`2:;Qrtt.'rC by the t.n.C•:5`.'; . 'l a•itl exc.:d c,.I oa oy t!ra c~:d of th:s .•~ar f::c industry t'::!l eon:i~;:+ ta s: t.',i.; example cf tiCT•, not area ''S2tti.1;j° tilteroSt, @i11f .hC Y'Jb11C :3IE•: e-t, 11•1J:y ..11:• cic!^. tS'iilitnt I:!ncpter. Jr.. Vice Prc;ir?;at. Pub'i; Tl.e Arr.c7r:caa':c'.:ccc Insta~~:, I-•c. . [' Ti` t i i 3 0146,700

EVE:•'•I.+G S'iAR PrtGiJ j%1-t Kli'rut•ric:'; on .Srno!;iy;g Sfft: This is in response to James J. Fal- patrick's recent column in tt•hich he su^_;atrl that the •rc•pu: ts by Drs. Oscar :leero_ch and E. C:1yi -.: Hanmond, tcilo stated that lur.; tumor; can rcaa'.t t:on1 c;garette s-,oking, were no% val:d. Addi::or.-Jv, he h2s r.iaae iomc statcnieats which are csscaaa:iy et`ccllra:o. Tti!re is cc;rrt reticn fo: our respa:.din ; at t`ts ft-::e.. l:'!!cn tac s: u;ect of someoac's hca!til s con- cc,:.ed, ::e o:l~:s is o:l thc rc;.orter to be cert:r.o ;ti?t be 1,:,, r:e.cnr,d =11 si••::, .: l::c easc• S'.nce :tlr. i:il- patric; !a.~ tha- is one of tac inr,e rrc•.:0 vc,;. . of p••:•r.i t:'ho t:' M u1 'E: t~', h•' . :!. ~ ~- . ..i :v L:1 t• 1':e co.^.t:c'c:i t:" ' zy:,nrc:i;aa :c!ical the Arac:ican Career Sac :ty and i:lso Dr. :1a_r'.-ac•n to be car;ain of our f=cls. Dr. 1tu-2rhac'.1 mr••i :',r. Fiamtt+.ond are coaracco:a int'r.s:irtz:ors t':ho persislcd i:l ;!:=ir recc.^.:ca ar.d adc we!I•::r.o::n au- thorities in the'.r f:e!d. 1':e ret•ie:ced Mr. articl•. u•ith Dr. Aucrbac:. t•:ho in•;!cat•.d taat !;c:e wcre i.cccral r^ c!a t•:hich rt:ccd cia::;':iz•~z. - The sciec .;~e p:,r„•• t:• 1: \a•. F:ilaa:r:c: reG?r: c l to v:. s puhli?`ed in the ':Arcyit•es o: F•^ • cn:?I Iicalth,' r.ot the ••rcL`.tc; of Ent':: - a! c!r. Tr•:rc tt;l: no in !Lc scic-r` +! e! tf ~! Pe '.i , Kl:h tl:cr j0'J"^8l Ui. 1:7s st:ic-en! btat:a•sa`s tr:li;h :c n.^t b'• :•II _ -s a::d ~ . I^ 1:c; to ti. rl. .a I)^. a p,.C-p:,ilti ;tl rf••Cc':Lr::n -tnt. :fi er.j in t!,: Triu::l:e a is~uca c: a r,~,ul•,r bas:; b) ::i could '; t,e rcpuJ!:St:ej in t.^^_ 'N2~ E':i.^"!,•JO-IC.'?l of ~IeJicir.,. tchic:l v;s standar•a used Ly o( the p:l'uaca:ions in the P.adica; . r,} fession• ii:c Jo::rnal of t:ie ar'.121•i^•^.^. :•i•?CI^;:1 •1;'^.- eiation did no>' rc;ect the ar:ic:e subrnittcJ b': D:. Auerh;ca and Dr. HantmoaJI, but suc:-es!c•J r:vi?i-g some of lile tScrdinj and sU ?i::ttlal? bl%ic•!: and tl'f:i:e prins o`. Fc.a.ter clarit}. At+:rbac t ard FIin:liosd fhnnn r'i•1 •.:!._. r•:': i5? z p:;.:, b:i! t::bn rick having itr ci+an,ed i;t' any a•ay, requc.;cd p:r- mission to re'r?ct ti:e na^er so that it coj!d t!te:, be publ!s^cd in ano;hcr :6I:1 publication, the ArchIc"s oi Env:ror.: c aal ii:alLh. Ti:is riport, t'ri:icll :o gr.W:y `disturb^d til•_ Tec;:cco I:tstitute, o:oved in eiirnce that lung c_r.cer could be developed by ;mak:l:; laboratory ar•imals. Proof Heretofore Lackin: Altho•j;h it had l:ag b:ca s~;pac:cd th3t sa:,):: "+ did b•r.:e i reta::oosnip to l::nG cancer, no prsof had hclrro'o:e czsccd. 1he T~tacco I:utitutc futth-r h.td sug:;~s;e.I t+la: if tF0~:c w'::e scch a ru!:ti•,n.~-.ip, a shr, ici h: .»tce;tratcd In ne ::.:iora:ory Aftc: ac:C t''as o;,t, thc Atner,ear• CanCer JGC:e:y revicttcd t:!c Gn_':r.; of'.'t::e::,i:4 and Iis:nr:t,rld ,:nJ accc,-:crl :i::.^.l pub;ic:y ort Fc`,:uary th•i A::re:i;in Tobacco thii c: t..... 1 THIS DOCUMQtT SUBJECT TO DONFIDEHTlA1(1Y AGREEMENT. Befo,r su:mitt:no t!tclr renart. Aucrb3eh ar,d Ha^• mead a'~o showed the;e Fito a null:ber cf pa!ho!u~i.i:. trl:o concurred. :11:^:`,r.:h sta!cri tnat they t:•o:+:J r.ot have stlbm ;ird :: c ~:r r tti!hu::: •::cir pricr app :•a. a!. The Aucrb:.::1 statCd, art on hi- &~:f o: On li:i at ;,I tir,lcs. Any p~.tito!o;ist o: a star: :;,; invitatio1 to visit his lab~)ratory and rct•,c : t.~e s:c• tiors v:i;`.1 him. On June 3, 1970, ?•uerh,cil wrote a letter to Sic!don C. Sommers, the ni^d::al a:;d scieniiiic d::ector of t':e Tobacco l:c.iaarch Ias!itt:t^. inviting hint to t•i;it h'.s laborr.!o:y and review ttt:", s'ciiolls t,i:y if ae n'islMd. So ;; mnrs was ovt c: the countl•y. bu: cabled fro:n A~j::ist:d. Sc:. Zn.nland, or.d sta:ecd tilat t!lis v:as a good idca ard t!:r,e shcu!d t;a o:,lcrs prczenc :s well. lie would co:ura I•.:nt on ha :c.:l:r. The:e's becn no t:erd frca S-3am.crs sir•cc. A!o:t p!I;:aicialu ate aS:src of :lucrbach's ss e°cs and reco?iizt t::eir validity. T`:re is a v:ry s;rt;r.; :$ C•^•c 0: til. !!iG:t 1.^.'~)Iifi li tliJ, ,,!t t':C ati of ae.3o,!. t `:o' bi: e smoi:Cri n1cSt of their lives v:i:i: na det•e;•). ment o; lun; carcino::•,a, it's cr.tirely p-issible that a pred~'.!:Ction for luna canc••r may be t•a :;erel by tai;acco We do ;'t et know t:•hat it is that sets t:::s horrit,le chain of e:c::;s on its way. Associated With 0:h:r lrisca?es But therc's rl:ore. 1i"sat Mr. F:iipatric!c hasn't re- ported is that c:;*:::e!te sntukino is nc: only a p~ter„ie1 se :ci of h_ :an - c: ee: b::t it .- ,r..laUt -ssoci• a:G t:i:l: t:t•,_ ~7 :. a, d•scas== ce: '!y cr.l;:•i tiw Tr ;::cc~ ir. a: te to tc.:k f.ir to ..... ;1_ p.,!- :~ e','' _.' . ... itr.ti Ci:.i:. e1:... ... t:••' ' to t::c p:c_,:n 7a! r.:o:: :: a;:d la: o`:• tn?t 'lA!1 C".^. :i 0..:0 S-.gcs ed t:•_t t's', t i: ~; bc :crti: l e• arc' to ie-d: "l':o:r,i-: ii :).i: ;rna, U Hca::h .nd :•iay Caq.c~ltr.l!' HC?•rt N.il'i.se. ChrdPlc Fa jl t:Ilnio.n.wt' .•, senta ar.;l O:i:•:r Ds;:ises. This is the ot:•:r itn;,b:t;:at th;: 1Ir. o.cr!c^k:d. Cte smokin; is probably thc s`.n ~,ie greatest ci'use fvr ern• physcnta. Along c:ith these other di3eases, emphysema is one of ta= nlost crippan; di5cases knott•n to nan':ind. In mcnV lt:Stanc?s, cc5s7:i0 t of S^.:CaL^.: has t•,:'.- 1 ber.efi;i?1 to th:se slcferin: iron: t::a=e d:r:al::es. A rc:pon.=ibi::;y of thc ~ii iical Socictv is to si::c• guard the llcal;ll of o::r• comrr.ur::ty. Fl:iiiilm:n: u.' this respo::iloility requires t'+:t the :•feoical Sc::ic:y respond to co:nments L`tat Fr,•i felt to b•a :nislcad17-.3 to thc public. llarvin C. Fiorcn;^!:i, M.D., Presidcrt. The itlediral Society o! t:.? District of Colu:tel:i.a. Jo!tu .`•I. }:cahiad.:n. M l)., Chairmvt, Public I::formati;ln and E<':lcation Colami:icc. P. Grr_; Gh,'dcs. Ni.!1. Chairman, ST,o'-:En; a:v3 Health Cxr•:,.fl:ac. , CTR HN 014'6't'~

L : ~' ..."~- iY.- 'eonard / L ry__IL PUBLIC RELATIONS COUNSEL - • /WIInV '` andAssociateAlnc. P. 0. BOX 523 • 13 LINCOLN ROAD • GREAT NECK. N.Y. 11021 • (212) 895•74a5 7HIS DOCUMEMT SUBJECT T February 24, 1971 IDOHf1DEHTIALITY AGREEMEN Dr. Sheldon C. Sommers Director of Laboratories Lenox Hill Hospital 100 East 77th Street New York, N.Y. 10021 Dear Charlie: As you will see from the enclosure, I had your letter from Zurich typed on CTR stationery and sent to the newspaper. Your letter had two minor errors of fact -- it was the Washington Star, not Post, and the officials were from the D.C. medical society. , / I recommended sending the letter precisely for the point you made -- that slience might indicate assent. Incidentally, I did not get a copy of the Star letter until yesterday. A copy is enclosed. Trust you and Edith had a wonderful time! With best wishes. Hope to see you soon. Sincerely, Leonard S. Zahn LSZ/hg cc: W.T. Hoyt Enclosures , 1 CTR ! !N 014GBO

THE COU\CIL FOR TOBaCCO RESL•'.iRCH-U.S.A., IsC. 110 EAST 50TH STREET NEW Yonh. v. Y.1oo_2 PflS DOCUMENT SUBJECT TO February 23, 1971 WNFlDEHTIAUTY AGREEMENT. The Editor Washington Star 225 Virginia Stxeet, S.E. wc~sliinyto:i, D.C. 20C03 Dear Sir: May I correct the statement of three officials of the Medical Society of the District of Columbia that by my not personally reviewing the Auerbach smoking dog material, in some way the claims made are supported. Simply stated, by premature publicity for their annual fund campaign the Cancer Society violated due scientific process and was thereby hurt. Failure of the J.A.M.A. to publish the study indicated seiious defects. Four investigators I respect who were close to the situation found no squamous lung carcinocr.a deronstrated. The evidence in the Dece:nber medical literature is unconvincing. No one is likely to use this experimental model again, since $750,000 was spent and zero squamous carcinomas can be accepted as produced. It is another of many experiments in which inhaled cigarette smoke did not produce cancer. Respectfully submitted, ~ Sheldon C. Somrners, M.D. Research Director SCS : ek 1 CTR HN 014681

~ ~A~~~~~~~lga~¢•~~~~~~a. 1Y DII1Mt ~ ~ I: `~j ~ ~~lix0.lk~e I an tf ia ;?r*ix~; ~ ~ R> 9 a . . o~ a ~ -~ I ~ A ~ ~ ~ - s ' . `%rtc . ~ ~ ~ g4 .• ~ ~r • ~~. ~ E"r'~ • ~ ~* , ~ .. ~ ~R ~ . !C O - '~.~„ •~ ~ .~ ~s ~ ~ ~ •• ~ ~R ~ ~~~ ~~s: S !t ~ c ~ svi ~ ~ ¢ g 1 5 1 8 '-; IF ~s~ I g x .: ~g ~ ~ - a ~ E w~ 8 Z. .. ~- sr Zv . ~ S 3 v r~ 2: ~:

THIS DOCUMENT SUBJECT TO DONFIDEHTIALITY AGREEMENT. March 19, 1971 Dr. Harold L. Stewart National Institute of Health Building 37 Bethesda, Maryland Dear Dr. Stewart: J Thank you for your recent courtesy and the educational benefits of your company. Enclosed is the letter in Washington Star, Feb. 17, and my reply , of Feb. 23. My answer has not been published so far as I know. I will / allude to it or read it when giving a speech.to Mass. Medical Society on Quality Control in Cancer Pathology, early in June. Best wishes, Sheldon C. Sommers, M:D. SCS :dg (Encl.) . 1 Ct ~ ~N 014663

Tin: Cou::c;ij. F c,it';'oi;:~Lcco Tsc. 1l1J 2: AcT S9T:L \J•:%S' TCIa:. \. 1'. ] 00~ 3 Fehruary 23, 1971 THIS DOCUMENT SUBJECT TO OOMFlDENTIAUTY AGREEMENT. / The Editor 225 Vir-~ir.ia Street, S.E. Washington, D.C. 20003 Dear Sir: Hay I correct the stat::ment of three officials of the 1`ledical Society of the District of Columbia that by my not persorally reviewin; the Auerbach smoying dog material, in some ,aay, the clai.ms nade are suptor*_ed. Simply stated, by prematu=e publicity for their annual fund campaign t1he Cancer society violated due scier,ti.fic proc~:ss arid ~~as thereby hurt. Failure of the J.A.td.A. to publish the study indicated serious d2fects. FoL:r investigators I respect who were close to the situa ion found no squar;ous lung carcinoma der..or.strat:d. The evidence in the Dece'iaer mcdical literature is unconvincing. *Io one is likely to use this experimental moda?• again, since $75Z-11,000 was spent and zero squautous carcinomas can be accepted as produced. It is another of many ex7eri-:ents in which inhaled cigarette smoke did not produce cancer. Respectfully submitted, Sheldon C. Soc7,-..ers, M. D. Research Director SCS:ek , CTP MN 014664

/ 1~,Jsltittgtoit, U.C. Feb. 17, 1971 _ _ ~ ' P ~.~r n • ,sl ^a ~~+!~ ,~i~ t1;".y0 Lti1 a ,! L In to Jz-mus J.• I:il- p °': c:i:ich 1•z sa;;~ast:' t'•:t tb^ repc:ts by Drs. 0.:-r f.u.rb_ch rnd E. Cuyl,r Am-nntond, a•ao tt'::d Ct:t 1~.1 tt::-ecrs Ca:t r:•:d: fro:n c:r•r;:tt: S:cra r.at va!a. Addi;ic:i_I!;, ta ts s:..:a ttat:c:.:ts vrsicit cr: c::..:!i:11y L:ccaat: L`LLs tL-n; ;. :-.i C:: s_a'^ct of h::altii ii cen- C: . t• : c::a', r•,i C:g r: t•, t: c"taln that !}~: c~' ....., i.. :'.1 th:; h: L on: c: tha lar°c frur) cf I, cc-,t! "it"] to ~r•to':^ ^ e.rt•st th:a L..•~t:: som: bic :J i:r th!s r:C=rd. Cla c~.' •^ ~ C:s Ar^.c*iva l::aic;.l As:c:i_!lon, tho t!:o Dr. At:: •,ch to 1•_ crtr.in t: c.r Dr. Au_,bach sr.d Dr. Hcmmc^d ara rho havc pcr:ls:cd In h.:!r re:c:rch and td. :.'s• tho;ilic In th:ir fiad. :7c rcvlc~ccd i.!r. Kilpz!r.c.:'s artl:Ia c.•iati Dr. Au^rb:cit, wi:a tr,d!c at'] L•vat thrrc az:o ta•crel r^'nts aiilcir r::J:d cl--'•:•:L•i•;. • ,i•bi ,yar that Mr. hil i=tric'.: refcrrcd to raa F_hli.i::d ~~ t;ta "Archih•ea of +.:avironmeotal ><I:1'.th;' eit tr. "A:chives of h:nvL-c:::n_nt_l Ncdi- C:'n i.:0 CJr: L7 I7 t: S(!l:3tLlC Cf.:.tent o' rs a I,,:: Ro•_'., have r'.ae:•:1 in t:,y way t.!`': ti:. :estn!ctioi c::c;a to C:: 1: .::ican C:.*.ca- siha Nca En;::e•9 Jcu,ztal ct '•Icdicir.: has r:•~:t C: m,:: by all .•:C:o:s ar.J ra'!c'.:3's'•ty v::rc ur.::;! • to y::b'ath th+ --:iclzs submittcJ by Dr. :1v:•rt: ch b: aas: ihare h:.d b::n a prc-pu!o:(cati~n o: crrtain statisti^s and quotta•;at in th= >iec!ical 7`i':ene• a n°-s7cp:r•typs public:!ien 1= u•a c:r ^ t;~s'~• t) :`u T~u~, t~^~ could r.ct ~b: rcp'_b'.~::::d Li t'te i\c:: Enoland Journal of ?I•di:!;:s, r,t•icb cv, tcl::~i^:e s'.ard:rd p-ux3--e a;:.l by r.t: ~i, cf t:'• in ti;a vi_dic-l p:o- fcssier,, i:: Jcur.r1 00 the American 1ledieal Asso- el:::: i 4:3 r.ct rc;:ct ih: article submitted by Dr. :-.f Dr. IIammord, but s•j,;;ested raa&tn; ac:nt c' C:o rro:dln ; t:Ai at rtibjtir. ; bleck Gr.d ~hite prL:!a c! G: r c!':1:~. Auc.-t_ch ar3 Iiammoild •tl:•~ c.d c. vcly 2 ti:: pap:r, bit rat'.:•r than ~ In any w:.y,, r:7t ~t'd p:r• rl `: t atl .,th=r :1 a. 1!::t t~~r.trz:t Ci) p•-•r so th:t it co•] t::en be p~_';~• :d in ar.ethc• /..'.A pubflc2`!:a, t}a Arc:dves ot i:: :.-onraa!s{ 'ihls rc;crt, wn!cn :a goatly d::ea :d tha iob_:c ~ Laih t:, ~re•.•ed in c:sance that lun; ccu'.1 Ae devc.:,'sd by •sntc•:ang lahoratoq zi.:ri•!s. Proct Iar::^fore Atf~:•j -!t 11 h2d lt= t:ea t:at stno`:Lng ~d t.: s a rdsc :^~ :i; ~t•a lur.J c:.-^^r, w pxo: had b!.... ;: ezistcj. 1::: ic5s:co Ir.:ate`.^ f,•rti::r bad t - :9 t it t:::1 ~-:re si:a a raaio_sT•.ip it tha at. 1" i dernoas:r. t::i Lt the 1_':oratory ..r.imnl lirst. Af: :' t rejvrt arzs e•:t, tt•s 1 r.:a::.::n C^.zc:r Sccic:y tc'r. .:.d t'•: t. -J ct a.*.3 F:za: _on.d and acc :d tk::a F.bl::'.y c•t 5, i'70. V : ' _..... . . .' ..._ :~•. 4 , THIS DOCUMENT SUBJECT TO DOMFlDENTIAUTY AGREEMENT. ' Betore s1:L•l.tittin~ t,:~i: repcrt, Au,,b:ch ac•] 'r'.art- mn,:d tl.:o s!:iRcd ti,c:: tLT!!-'1 to n ct w110 f.1::~:.Ca (ia thiey COu!;1 *.9: h:.v2 s•:at::, ar• o:, kis C'cc c: c.t ;:is i icr::cc; :-t y: i! t:.m'.a. Any c~t`~ioJ: t c: u:zr.;ist t:, i.v: -:ira 0 ii>'.t h1s 1-`_:..aC:y a_r,d rt:ieu; ta;,ns F•itit h?-tt. On.'•'..:3 1~", ,,, %•:r.`. _ I•:'-_,,, :...,;i C. .°: :.'-,•.s, tha m :l-.~-d s' tit:. c r: . cf tl:: ^.cb,c,). T:_ :rch hiLt tr+ V~:-i; i,ia laL+:ctc:y r:r.j r:v:aw ll:: s:c':cns v,i~L hi ;t if he t:ica^u :•xu •-; vas cct c: t~a cou•'.ry, .c-T.:d tr. =: AeNI~_;, lr:w a.rd n:-tcd tl'a: t' n r.d tho;c slaad L•a oti;::; prc": _:.:a. K, v:,,-jid co:,t:ct him c-, his .cturn. 1:ca Yinst pby:ici-r.; tr ! ttv:.;-e c: Aue:b:cii :.'-. iic3 tr] rCCO;,71L: tL:ir v:!!ai:y. ia a vt:y' . su, ;stioa t;i^t t:nc::L^; i.; cn; ol tt:a ntc-! i,..; .:nc fr.acrs In t::: cau::,t:os c! lur•J Wrnors In r~a. A!• tF,ouZh cc a!l L•r:ca of p:::oa cno Lav: srao:::' --:st of their Iiv:.; vit3t r.o d:~:: nrn:at of luag cac:.:ra, It's crtirely p:abl: t!i:•t :: r::.dil:ction tor h:r.; c:r.:;r mcy'Z;a trr-;;_rcd by t::^:.cco smc:<e. 17e d:::'t yct Ynoa ahs,t 16 ti:=t r:a thA3 horribl: ch--in• c: ;:znts on its way. . As:ecla't; Wf!1: 0'+.cr Dis_ases • But th^ra's ztora. 17bct Mr. K!!patric; b:sn't re- partcl is that ciJar:tte s:.tolin; is cot wily a Fat:itial :cu:,a oi hu:r.ar. 1!u-, c:_%:r, u•jt it i; actually a:zoa• atcd )-i!h c'h:•r di: tcs. Ti:; S :;,~ Gc.^.:ral, t•rho li:a s~; c rt ~ Aue:ba:ii's Cc:d•u,_ : rc• Cc:.aY C?I':1 tl'.3 TO!']CCO to t2:G f^r l::1l!La m!sl:^Jin;, ress;utino ststor.:ents to s:ao:un; prc_:an: •-Ce th~t :-.. ;- v7C•i to• tl:. Fi:;~.7?nt iit:il:.°r a..^.] L.. c• t• Ss i.l ; ~ F:bllc La*7 (Fr; E':!3) o' A?rill, 1~-:', :`''±; th::t ell cl-: rct!) shall c^rry c:. :?: ^s y:LitLt, ~~~;_:;iLng 'i:nS•smo'ci:nJ Is dzn•+:ra_; ta t:.t l::ath. 1~1 Sur; r.n Ger.cial ~•:s c; :a ru3- aa.t:d ti•:; :.ez: btg t: t7v.;'ch:t:a ezd to r:ad: "1'Jarnir.g, Cimorette Smo!<iaS Is Dan,,:rou to He21t;t and ?.Iay Caua: Daath From Cancer, Coron:.ry Il:7rt Dis^ase, Chronic Erc::c:titis, Pulmonary Ernphy s:r•.ta a nd Other DL-cascs." This is the oth?r tniYortant material that \ir. Kill•atrictc ovcrloo'icd. . Cigaretta sui:1•i;,3 L prubaoiy t;:: sir.;l: g..,ieat cau:e Ic: em- jhy::ms. Alon; a•Ith th::; other discases. cmph!;::ma b of tha mc:t c;i; pling diseac; i no%s-n to mar'ar.d. In many insta.^.c:., eessation of smc!cinL,, has t3eo b:-eficIal to thc:; cuf::rin; from those disc2s:3. A respomiMity of the Medical Society is to :--te- guard the haalth of our contmunity. Fulfillment of this res,?r.sibility requires that the SIedical Sxiety respond to commcnts that arc felt to be. misleads; to the pub!ic. liarvia C. korcn;olJ, 11.D., Presid;nt, The Medical Sxicty of the D'utrict of Colu: ,:;a. Ja':n M. 1;eshlsbi:n, S1.D., Chai.-man, Public Ir.tormation acd Educa!iot Co-.rn:ittca. • P. Gres; T.So3:i. `•i.D. Chairman, Smo:3n; and Health Comniict::. \ , i E.r ! R ! ! 1 "t t..r 1`.'r 665'

TFrr•. Cov.cIc, Tocs Toi;.,Lcco RESLAacu-t.S.A., I.c. 110 EAST 3UTH tiTRF.FT NEW YoRt;... Y.1oo2a 1}IIS DOCUMENT SUBJECT TO Wt'IFIDEHTIALITY AGREEMENT. The Honorable Frank E. Moss Chairman, Subcocamittee for Consuners United States Senate Washington, D.C. 20510 My dear Senator Moss: Since returning fron vacation I have th:ougit how best to respond to the questions attached to your letter o: February 23. ':':ere are certain typing and other errors in the q,.;estio :s, but I will att:-_Dt to be responsive to what is believed intended. To avoid confusion, _ have reproduced each question by photocopy imr•,e3ia-tely preceding .;,,v answer. .1. - In your testirr.ony you suggc!sted that there is a serious scientific bias which enters into edir:cological c-0;1parisons bet;reen smokers and non-sr.okori. You indicute tha:t r,:; ..._-the:Tatics exists fcr statistical comparisons of random selected p,;,ul,:!{ions and that peoeple self-select %•.d:ether to s..o~e or not; thus the pcp°ulations studied are r;,t random. I think both of t1hese assertions can be put together to ask you the question, even if cigarette sco'll-ing werz not a health hazard do yc:r agree that epider..^ological data shovrs a greater *"cidence of prE-at;;re death and disability among those who sr::o:e cie:-re:tes than aTong those ;;^o do not sooke cigarettes? PreTature death does not mean an,vt~-,in.^ to ne eYce^t r.c=s':;1•: the death of a orenatt:relv born orc_anisa. ^he so-_allea cc'.:ort c_~^~ ~-_-ent obser•:ed egidemiolouicall;• in cigarette s okers az,. =ars to be a sta_'_: __=~1 artifact representing. chanciag ;cpsiation habi_s •Y:=h *_ime now desi;r.ata4 a secularity factor. The ^atter is considered at crE-:ter length ir. t:-.e 4 anal;:sis of the 1959 caper of Cornfield et al., ...._:h vo•a r=i-_este-r. finding probably has no.healtn signi°icance, an: once it bece,.es ~ to be a source of error it will lose ._n.i Dractic3l e:)i:3c^:iolegic val::-o. 1 CTR HN 014666

2 THIS DOCUMENT SUBJECT TO COHFIDENTIAUTY AGREEMENT. 2. Even if cigarette smoking does not ee"--se disease do you believe there is data to support a dose response relati=sF,ip indicating that t`,os who sma:e highe r tar and nicotine c,isarettes se e= to get the diseases attributed to smoking earlier and die earlier irs life than those who s-o~e i 1 lower tar and nicotine cigarettes. The matter of cose-response clri:as rela ~ing cigarette smoking to disease was discu;sed at length at a neetino ;r the Subcor.mittee of t_'le Joint Ccr.mittee on Tobacco and ::ea1=z. There se=:..-a-d to be agreement t::at dose-res: onse was a c=cper tern when applied to -fa..rious physiological and biochemical events, like heart rate and oxygen =er_s::n;tion, but that tne term could not oro=erly be arplied to disease endr:oints. In other words, dose-response is a misused tem in this context. If you simply -ean that people who smok:e higher tar and nicotine cigarettes are supposed to get diseases and die e,--rlier than those ::ho smoke cigarettes with lower -sr and nicotine, I know of no data that demonstrate such a relation conviningly. The orelininary ser ::~rts coroaring filter a nd nonfilter cigarettes do not permit any definite cc.-iclusions. 3. Do you believe there is a suitAble bio =assay model for lung inhalation studies? At oresent a C=R-devcloped inhaiati:n _=st system involvir.g smokir.g ^achines an3 la:>orstory animals is u::aergoina testir.g both and from the : ie'.:coint O: 2ngi.^.ee=i.^.g cS1a=a_-=e::5 t_ __::. : t i s tacu^• ^'_ the best yet achieved, but at least t,::o additic:::.l ns•:r -.sc'.:inc ^ocels are becoming available as prototypes. Their suit3:.ilit'1 :.e':e.^.ds c:1 the .^.ee':s of the individual investigator. '•iy oginion is that t:ere is still =ensic:e_a:r,le room for i-+proversent, b a that fresh ~•:hole cigarette s-sot:e car. no:.: be delivered to the resoiratorv tract of animals in a^.anr:er si:;ilar to that of human s-^okers. As to :,iaassay, the usefulness de_^=.^.cs on what it is desired to assay. CT~' HN 014687"