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1HIS DOCUMENT SUBJECT TO CONFIDENTIALlTY AGREEMEN.T,, I (04).JC010 RAC027- CPRZC CLAO2," ZC V I A CANA01 AN ItitA702 TFZ144 G41 USNY HL FISX 072 NADIFIJI 72 17101~, LT ''Pn JU"1 17 AM I .5 u T,HLktAS HOYT COUNC IL TOBACCO RESEARCH 110-E-59ST NEWYORK WY CABLE TO AVERBACH FOR:d AUCKLANO QUOTE " INFORMED OF YOUR INV I TATI ON FOR ME TO REV I Ew YOUR AND HA.uuONOS BEAGLE EXPER I4EVTAL MATERIAL STOP BELEIVE DESIREABLE ALSO TO PEWIT OTHER INDDEPENOENT EXPERT TO SHE THE SLIDES AND PROTOCOLS SINCE AS RESEARCH DIRECTOR CTR THE COL LT HOYT 110E-S9ST PROTOCOLS ZsrtA7o8 I CTR HN 014668

1HIS DOCUMENT SUBJECT TO GONf1DEHTIAUTY AGREEMENT. ^W REv I=+r BY ME ALONE u I GHT BE CONS I OERED B I ASED STOP ON F3ETURN JUN: 2E WOULO AFPREC IATE FURTHER OPPORTUN I TY FOR 0I SCUSS I ON REGAROS UNqUOTE SO4aFRS COL 2ES"AERS , sl6ts, v&M CTR HN 014669

THIS DOCUMENT SUBJECT TO WNfIDENTIAUTY AGREEMENT. Ptcvc.:'_•er 2, 1)72 / Sheldon C. Somers, M.D. Director of Laboratories Lenox Hill Hospital 103 Last 77th Street New York, tiew York 10021 Dear Doctor Soaaners: This letter will confirm our discussions with you concerning the fact that the time you expend on matters related to The Council's research progra^ is so frequent and intermitter.t that it is virtually impossible to relate it to a per dien basis. Therefore, The Council, beginning aover.ber 1, 1972, will conoensate you for your advice and consultation by a fixed fee. This fee will be figured at the rate of $15,000.00 per annucs and will be paid to you at the end.of eac:i month in an amount of $1,250.00. It is unde.-stood'that The Council will rjake no withholdings for tax or Social Security alt:~ough the fee will of course be reported at the end of the year to the Internal Revenue Service~on Forn 1099. Sincerely, W. T. Hoyt Executive Vice President wTH:ek CTR MN 014670

THIS DOCUMENT SUBJECT TO CONFIDENTIALITY AGREEMENT. Januasy 4, 1977 / '1r'mORL*7B!~*! TO: Robert W. O'Keefe FROM: W. T. Hoyt Effective January 1, 1977, Dr. Sheldon C. Sonsnera will receivw $20,000.00 annually in paynent for his services. W. T. Hoyt WPH : ek , CTR HN 0 1416" 1

THIS DOCUMENT SUBJECT TO OONFlDENTIAUT1f AGREEMENT. (~ I . A DIVISION OF LOEWS THEATRES, INC. • 200 EAST 42ND STREET, NEW YORK, N.Y.10017 •CABLE ADDRESS LORILLARD ARTHUR J. STEVENS VICE MEfiDENT•OENE~At COUNSEL (ttt) ft}~6.7 June 19. 1972 i Sincerely yours, a Sheldon C. Soemaers, ri. D. The Council for Tobacco Research-USA 110 Zast 59th Street Mew York, Dtew York 10022 Dear Charlie: I~ly colleagues at Lorillard join-me in expressing to you our appreciation for the services you have been rendering to the Council as its Research Director. Th.re is no doubt in any of our minds that whatever success the Council has achieved in recent years is in no small measure attributable to your assistance. Me are indeed fortunate that you are in a position to remain involved with the Council as Chairman of its Planning Comaittee. Once again, many thanks for your assistance. Rind personal regards and best wishes. AJBI AC cc e ltr. a. 8. ~ ` ,l~cthur "J. Stevens CTR HN 0146•{v''.

THT; COUNCIL FOR TOBACCO RESEARCH-U.S.r1., hIC. June 15, 1972 MEMORANDUM TO: Scientific Advisory Board FROM: H. H. Ramm THIS DOCUMENT SUBJECT TO CONFIDENTIAL{lY AGREEMENT. Dr. Sommers has resigned as Research Director of The Council but will remain a member of the Scientific Advisory Board, continuing to act as its Chairman and as a member of the Planning Committee. Dr. Gardner is to become Scientific Consultant to The Council as of July lst. During the next twelve months Dr. Gardner will devote approximately half of his time to The Council. After that it is anticipated that his appointment will be on a full-time basis. . / All of us owe a great deal to Dr. Somzaers for his outstanding leadership and service during the years he served as Research Director. He gave generously of his time, often at great sacrifice and inconvenience to himself. His wisdom, knowledge and good humor helped enormously. H. H. Ramm HHR: ek 0 CTR HN 0146~~ °~

MEDICAL COLLEGE OF SOUTH CAROLINA 80 Barre XDiXMxpIJwTR!!T CYUUtIesTON xa, SOUTH CAROtINA 29401 THIS DOCUMENT SUBJECT TO CONFIDENTIAUTY AGREEMENT;, April 22, 1969 Dr. C. C. Little ecientific Director The Council for Tobacco Research-U.S.A. R. F. D. 1 Ellsworth, Maine 04605 Dear C. C.s I am indeed glad to hear that Sheldon Soammers has accepted position as Research Director of CTR. It will be good for th. parent organization, as well as for the SAB. Possibly you may have gotten implications from the copy of my letter of April 18 to him, which probably crossed with your letter to me. iPhile I had no idea at that time that the addition of him to the staff was in the mill, I meant to go as far is might be proper in indicating my judgment of his value to the organization. In appreciation, and with best wishes. Sincerely, Kenneth M. Lynch, M. D. l0lL s j ch Copy also sent to N. Y. office. ~~ CTR HN 01467`4

DEPARTMENT OI MEDICINE UNIVERSITY OF SOUTHERN CAUFORNIA SCHOOL OF MEDICINE 2020 ZONAL AVENUE LOS ANG[LLf. CALIFORNIA Y00» CAnTOL 5.1311 THIS DOCUMENT SUBJECT TO OONFIDEHTIAUiY AGREEMENT. April 21, 1969 Dr. Clarence C. Little The Council for Tobacco Research- II.S.A. 633 Third Avenue New York, N.Y. 10017 Dear Pete: I have your note of April 16th. I think it is great that Charlie Sommers will devote part-time as Research Director of CTR. It is a most logical choice and I look forward with continued interest, to working with the CTR staff and the SAB. - He called me recently about the meeting in Washington, D.C., at which Secretary Finch was present. From his report it sounded as if it was a most sucessful discus- sion concerning needs for further research on the relation- ship ship of tobacco and health. I, too, look forward to seeing you in May. Most sincerely, Claytdri"G. Loosli, M.D. Hastings Professor of Medicine and Pathology CGL:jh CTR HN 014167"Ej

• 4 Z-111• O[/~fTtl(NT O/ -lO1CIM[ ?HIS DOCUMENT SUBJECT TO QONfiDENTIAUTY AGREEMENT. April 21, 1969 Clarence C. Little, Sc.D. Scientific Director The Council for Tobacco Research 633 Third Avenue New York, N.Y. 10017 . Dear Pete: Congratulations on having gotten Charlie as part-time Research Director. man. You could not have gotten a better All good wishes. Sincerely yours, Richard J. Bing, M.D. Professor of Medicine Chairman, Department of Medicine RJB : vw WAYNE STATE IINIVE•RSITY 1400 CNRYfL[R FR[[WAY SCHOOL OF M[OICIN[ OCTROIT. MICHIGAN 40207 CTR MIN 0146" 6

I lH1S DOCUMENT SUBJECT TO ODtIFiDEMTIALITY AGREEMENT. Mirtvo tou; :, l.orord S. ZLhn March 25, 1971 Dr. S.C. Sot>mmers New York Charlie-- Just received copy of WK's letter. Perhaps this expl.ains wl~y your letter was not published.' Sincerely, / ~1ZQ?1~ Al ahn `~° a~ P. 0. BOX 523 • 13 LINCOLN ROAO • CRCAT HLCK KY. 11021 • fZ171 l9S74IS ~ kip '. CTR ~`IN 0 1467 '~~

s rAk LETTERS TO TEiE EDITOR 3-17-71 Page A?.6 ?H1S DOCUMENT SUBJECT TO OOIiFlDENTIAIlTY AGREEMENT. ~ ~r ic c, ~t~ i• . ~ ~r-~ :.•~ fs`i.:.~ [7A n.~.~. lait~+ d E ~0 t! il t•cs i:-a v: tr t :J ! Tobacco l;Isti:u:e Replies SIR: Recently you publisF.ad a ler.gthy lett^r from thrce officials, i::cl;'dia; the ores: =n', of the 11ec,i'al Sxiety of the Di.~uict of Colum*o'•::. pttackizq a rccc ; rcpart by Coluln :ist J::mes J. 1:E.patrici: ow the rc:o- rious "smcking dc:;" rCSe3rch of 15ii>. Mr. Kilpatrick can !:a:rr:le his a•..n of ccuraa• tvt :rc car: ot pcr:•:it }c_r rcad^rs to I•c r.^.isgt:kI.cd ; the a_sertions of the Il:ree do;;o:s v:!:o:e lea,!r Y.1i published. Certain of th:9: ^d Q7f ~'n. incluoing tne:r statcrncr.; th• t t:: "1 t: ^"_: t~ ~: ~ c~= < t.port v.as pub!isacd a•'ear agc. "it I.d luag bc: -, st'.p(•ctcd thzt smo:ir; did hzve a rcia:i:ashjp :4 canccr," Lut "no proof h.d . It zpp:ars, t', .::•e• cr. that In sc :rz:; resp,cts the three do:t4tY hat•e be:n se:ioas!y rais:ed by t:::i: solrfce4 of In.ArrAatioA. The cllron4!ogy 4f the "siros:::; d'ves" cll:so::e 1.' signi°icaet. For more ttian tao ;:c•ars. usir•- sornt tnrce•q'iariers of a mil'ion doilas .>• t:ie Amtrican ('a::c'rr Soci::;• z~d th^ l'!••:rp:.i :;d:airi-!ra- ti;r, researchers had a n•o::p of oaa":_ dr.;, ci,,arc;l.:s t!l:ot.,-h ho!cs c.::n t;:cir I'.Cyc•rtefl i!:cIP 1'tn'!:::ZS 6n CCJ[ua.'y 5, :970, tn: 5.'ICna 'S 1;~t 5-i9 r~r4:!cd thci; find;ags t,> an n^:e::can Ca::==: ar:d to thc p::::!ic :; a lar::: n:..: cn..i :.,...r it: :i.. ~ti 2!( :: -~cC iCla ~O:Ci al ~ :'c Then t~^ "acs+• Jrit:r•t:_l of rc- f::=:d :o p....!i:~, :c=ir b^caus ~ ...c~ ..:i cc5t•crcd tlarC: first to :!'C G:.:S TFen, i:, J':::^, thc rescarc!x:s d:i!t'erei:r:s•ver- sions of th•ar -cpcrt to t`c .~:•iA co: :'c-".ca in Chicaco. Tt:er. the "Juara:.l of t:^. An>cri:an :•:ra::al Associa- tion" rc;e::cd t':l-ir re;)•::a for publicL:!o:±. Then the a•a:hors su:;:nit:cd ne•r: re~?::s to "Ar- chi~•cs of f:cviror..^ _r.:at i;e4ith" c•n ahc+:e editorial bclyd, :,s s:ertes. 7ha e•iito: ef that ;^urnal c4: : e lcd s r,.•:aing in Jul.y Vci'h the authors a;-.1 a %e:,:inrrr empia':ed by a Pi:i,ad;!p~: d:ug co^ pan}' ra it c firm's heldauarter_, to ~.rork oat er.ou;a c;l:.:.?ea i:. t:ie xianu- scrips to ::a;e tbc:n suit ,b!: :or pub'.:=ador Tec final ve:•sio~s of t` a papers a;; :arz-; in Pra,: in Dcce+nb: r. Contrary to the state-ent by the thrct Cr:ars t1:3t "these tl•a; no chan;e in t!te scien:itic cc•^'°it of t} e paws %:fiich would i:a.e ciffered in a.y wafro:r. t^e initial t•CesiOn, t.here Kere, i.^i f:,ct, nt::r..ro" ae:: xa;or chan;,.s. Onc of these u•as dc!ctici• in the Dc_cmb_r reri+on, of a state~ F.u:pxe of :i'o e\pcrinlr.-it in Fen:l::y ve;slon-'`to a-,~rt in v:h_:i:c: srno::i: ; c!: i:c:tes for t-wo y^nrs cr ica,t•r wii! p:cacce lur:; j:an•::: in d.:C7.'> Co:dr~:y to t.-.c S:-;c, .rt by thc• ,.:rca L:•: :ors. !!ic pa'h:+loo:sts v:!'n :c•i thi; rc,.n.:.:ca t.:c)re 1._t F cL:,,.~ry did not all cv: cti; :n c:.c fil: ':,. Con: ;y 'o , by .h.. _ r. . I:.. t; ::r uc:. at a... s: i:n he at: in \c•:• 6.1 r~:•t .:ic oJ r:crt'rri> - lie Ni1Td t/~:5 r".rly_. i , "Am Inl4:,:it`:1 of )o:tr iril'It]!lar: fOr T1:c t', ynur ... b:a,I_ exr:rin:cntll mat^riat. ~c ble also to fc:r:it o:i-cr ;o %r• :- slidcs a-td prvt4col si :c. as rc-carch dircc:ci C:=. recicw ty mc ais :: n;i;;h: be r•,nsidcrccd cinsco. ua return . v•ou!d ap?rcci: tc furt:;c: c;,;>,,:,uri'.y fo: discussio;l.'- Tcvcr Itcspol:dcct The rc,^:,rchcrs na•: er rc=; on•:c:! tn hirn. The thr.c doc;nrs :ay th'_ a!::iors tnission to re;r..ct the paper'• freal ti:r American Mcdic•al so t!1: :o,tX. ~ .s:i t. eluwh.ere. Thisisc^rt2:r.ly Ti:- :att i: ...: t, auth~rs r,:eit to ar,othcr FuL1i~:.t~o l 1':tit "-•r :t. •r . Sn_rlpt°_. rt;'1SIf.~ to ar•J Gc:.l iP"' :„ t^;!- W 7 whom J:.`i.1 t*d ;;uoroittcd t',e paae,s for rr..: . The three do•:t~rs s:ntcd cc.:e2:'° tt•:1; the :'•;~_Cc> Institute r!(,~.•< r.at .^:CCI:: Iil'.i CXjlci i^.!:;it, ?:i : T?•I. 3s any p:c~f th3t ci';arettc come ill. As r,lost e::pcrts in the fic!d*arc' a;t rr. :xicntists have l>°en attr:n?t;r~ to prodece in aNmata for taree decades :- r::oro r:6.4 c; ci~arette s;.lo::e. and have : ilci. tt,is \atic:lal Czr.ccr Ini::t;:cc's 'aa!.a_e foct:sith considcr :bic funas ard ict ;i- ,~ :- :e: ar.im: I c~;•e-ir.: ^tat na rlc:!lcds c'n •!d r-r•a- ble ar.a•.:; cs b:n.. t!:c ::rco c'i.: urs h::':e cx:):`: lict th.-t dLtC'_Se; S.!i s!r._clc ;rczt•a: c.:.:3e :or reo•t~ct 0 tfCAl a: t'Si -" ith ti•^_ Na:' r lC.. ''l.. . -A'!'!C!i s-~iCi -i: a'C!lr:2::a it- nla: dna't kr.. t':e ca, -,. n^.`yi i}'Cir: o[ f::Jri iO,C?t?~li5h ai)OCt sn:0~ali~ ar.d f:atCil. in a q:::cksancl of itLt: :ical o;= • t: ._-'t. th^se "rr;> h: lie;cd it cc,i':t- A'!th the ciuiC? of thr0? of :e'I2r~est ~•4~:'..ta-''..,1:';I riisicg a:sncic!lor:, ir+ th•: co:n.r~•. in the a: c a,; canccr, h^art anti di;e; _T;. The toL_cca it:.:•istry itseli re:^ `ns the ;ar;;;t contriba'o: tn ;~c rEie~tcit Iil ing and heai:h-,:ri C'.t`2:;Qrtt.'rC by the t.n.C•:5`.'; . 'l a•itl exc.:d c,.I oa oy t!ra c~:d of th:s .•~ar f::c industry t'::!l eon:i~;:+ ta s: t.',i.; example cf tiCT•, not area ''S2tti.1;j° tilteroSt, @i11f .hC Y'Jb11C :3IE•: e-t, 11•1J:y ..11:• cic!^. tS'iilitnt I:!ncpter. Jr.. Vice Prc;ir?;at. Pub'i; Tl.e Arr.c7r:caa':c'.:ccc Insta~~:, I-•c. . [' Ti` t i i 3 0146,700

EVE:•'•I.+G S'iAR PrtGiJ j%1-t Kli'rut•ric:'; on .Srno!;iy;g Sfft: This is in response to James J. Fal- patrick's recent column in tt•hich he su^_;atrl that the •rc•pu: ts by Drs. Oscar :leero_ch and E. C:1yi -.: Hanmond, tcilo stated that lur.; tumor; can rcaa'.t t:on1 c;garette s-,oking, were no% val:d. Addi::or.-Jv, he h2s r.iaae iomc statcnieats which are csscaaa:iy et`ccllra:o. Tti!re is cc;rrt reticn fo: our respa:.din ; at t`ts ft-::e.. l:'!!cn tac s: u;ect of someoac's hca!til s con- cc,:.ed, ::e o:l~:s is o:l thc rc;.orter to be cert:r.o ;ti?t be 1,:,, r:e.cnr,d =11 si••::, .: l::c easc• S'.nce :tlr. i:il- patric; !a.~ tha- is one of tac inr,e rrc•.:0 vc,;. . of p••:•r.i t:'ho t:' M u1 'E: t~', h•' . :!. ~ ~- . ..i :v L:1 t• 1':e co.^.t:c'c:i t:" ' zy:,nrc:i;aa :c!ical the Arac:ican Career Sac :ty and i:lso Dr. :1a_r'.-ac•n to be car;ain of our f=cls. Dr. 1tu-2rhac'.1 mr••i :',r. Fiamtt+.ond are coaracco:a int'r.s:irtz:ors t':ho persislcd i:l ;!:=ir recc.^.:ca ar.d adc we!I•::r.o::n au- thorities in the'.r f:e!d. 1':e ret•ie:ced Mr. articl•. u•ith Dr. Aucrbac:. t•:ho in•;!cat•.d taat !;c:e wcre i.cccral r^ c!a t•:hich rt:ccd cia::;':iz•~z. - The sciec .;~e p:,r„•• t:• 1: \a•. F:ilaa:r:c: reG?r: c l to v:. s puhli?`ed in the ':Arcyit•es o: F•^ • cn:?I Iicalth,' r.ot the ••rcL`.tc; of Ent':: - a! c!r. Tr•:rc tt;l: no in !Lc scic-r` +! e! tf ~! Pe '.i , Kl:h tl:cr j0'J"^8l Ui. 1:7s st:ic-en! btat:a•sa`s tr:li;h :c n.^t b'• :•II _ -s a::d ~ . I^ 1:c; to ti. rl. .a I)^. a p,.C-p:,ilti ;tl rf••Cc':Lr::n -tnt. :fi er.j in t!,: Triu::l:e a is~uca c: a r,~,ul•,r bas:; b) ::i could '; t,e rcpuJ!:St:ej in t.^^_ 'N2~ E':i.^"!,•JO-IC.'?l of ~IeJicir.,. tchic:l v;s standar•a used Ly o( the p:l'uaca:ions in the P.adica; . r,} fession• ii:c Jo::rnal of t:ie ar'.121•i^•^.^. :•i•?CI^;:1 •1;'^.- eiation did no>' rc;ect the ar:ic:e subrnittcJ b': D:. Auerh;ca and Dr. HantmoaJI, but suc:-es!c•J r:vi?i-g some of lile tScrdinj and sU ?i::ttlal? bl%ic•!: and tl'f:i:e prins o`. Fc.a.ter clarit}. At+:rbac t ard FIin:liosd fhnnn r'i•1 •.:!._. r•:': i5? z p:;.:, b:i! t::bn rick having itr ci+an,ed i;t' any a•ay, requc.;cd p:r- mission to re'r?ct ti:e na^er so that it coj!d t!te:, be publ!s^cd in ano;hcr :6I:1 publication, the ArchIc"s oi Env:ror.: c aal ii:alLh. Ti:is riport, t'ri:icll :o gr.W:y `disturb^d til•_ Tec;:cco I:tstitute, o:oved in eiirnce that lung c_r.cer could be developed by ;mak:l:; laboratory ar•imals. Proof Heretofore Lackin: Altho•j;h it had l:ag b:ca s~;pac:cd th3t sa:,):: "+ did b•r.:e i reta::oosnip to l::nG cancer, no prsof had hclrro'o:e czsccd. 1he T~tacco I:utitutc futth-r h.td sug:;~s;e.I t+la: if tF0~:c w'::e scch a ru!:ti•,n.~-.ip, a shr, ici h: .»tce;tratcd In ne ::.:iora:ory Aftc: ac:C t''as o;,t, thc Atner,ear• CanCer JGC:e:y revicttcd t:!c Gn_':r.; of'.'t::e::,i:4 and Iis:nr:t,rld ,:nJ accc,-:crl :i::.^.l pub;ic:y ort Fc`,:uary th•i A::re:i;in Tobacco thii c: t..... 1 THIS DOCUMQtT SUBJECT TO DONFIDEHTlA1(1Y AGREEMENT. Befo,r su:mitt:no t!tclr renart. Aucrb3eh ar,d Ha^• mead a'~o showed the;e Fito a null:ber cf pa!ho!u~i.i:. trl:o concurred. :11:^:`,r.:h sta!cri tnat they t:•o:+:J r.ot have stlbm ;ird :: c ~:r r tti!hu::: •::cir pricr app :•a. a!. The Aucrb:.::1 statCd, art on hi- &~:f o: On li:i at ;,I tir,lcs. Any p~.tito!o;ist o: a star: :;,; invitatio1 to visit his lab~)ratory and rct•,c : t.~e s:c• tiors v:i;`.1 him. On June 3, 1970, ?•uerh,cil wrote a letter to Sic!don C. Sommers, the ni^d::al a:;d scieniiiic d::ector of t':e Tobacco l:c.iaarch Ias!itt:t^. inviting hint to t•i;it h'.s laborr.!o:y and review ttt:", s'ciiolls t,i:y if ae n'islMd. So ;; mnrs was ovt c: the countl•y. bu: cabled fro:n A~j::ist:d. Sc:. Zn.nland, or.d sta:ecd tilat t!lis v:as a good idca ard t!:r,e shcu!d t;a o:,lcrs prczenc :s well. lie would co:ura I•.:nt on ha :c.:l:r. The:e's becn no t:erd frca S-3am.crs sir•cc. A!o:t p!I;:aicialu ate aS:src of :lucrbach's ss e°cs and reco?iizt t::eir validity. T`:re is a v:ry s;rt;r.; :$ C•^•c 0: til. !!iG:t 1.^.'~)Iifi li tliJ, ,,!t t':C ati of ae.3o,!. t `:o' bi: e smoi:Cri n1cSt of their lives v:i:i: na det•e;•). ment o; lun; carcino::•,a, it's cr.tirely p-issible that a pred~'.!:Ction for luna canc••r may be t•a :;erel by tai;acco We do ;'t et know t:•hat it is that sets t:::s horrit,le chain of e:c::;s on its way. Associated With 0:h:r lrisca?es But therc's rl:ore. 1i"sat Mr. F:iipatric!c hasn't re- ported is that c:;*:::e!te sntukino is nc: only a p~ter„ie1 se :ci of h_ :an - c: ee: b::t it .- ,r..laUt -ssoci• a:G t:i:l: t:t•,_ ~7 :. a, d•scas== ce: '!y cr.l;:•i tiw Tr ;::cc~ ir. a: te to tc.:k f.ir to ..... ;1_ p.,!- :~ e','' _.' . ... itr.ti Ci:.i:. e1:... ... t:••' ' to t::c p:c_,:n 7a! r.:o:: :: a;:d la: o`:• tn?t 'lA!1 C".^. :i 0..:0 S-.gcs ed t:•_t t's', t i: ~; bc :crti: l e• arc' to ie-d: "l':o:r,i-: ii :).i: ;rna, U Hca::h .nd :•iay Caq.c~ltr.l!' HC?•rt N.il'i.se. ChrdPlc Fa jl t:Ilnio.n.wt' .•, senta ar.;l O:i:•:r Ds;:ises. This is the ot:•:r itn;,b:t;:at th;: 1Ir. o.cr!c^k:d. Cte smokin; is probably thc s`.n ~,ie greatest ci'use fvr ern• physcnta. Along c:ith these other di3eases, emphysema is one of ta= nlost crippan; di5cases knott•n to nan':ind. In mcnV lt:Stanc?s, cc5s7:i0 t of S^.:CaL^.: has t•,:'.- 1 ber.efi;i?1 to th:se slcferin: iron: t::a=e d:r:al::es. A rc:pon.=ibi::;y of thc ~ii iical Socictv is to si::c• guard the llcal;ll of o::r• comrr.ur::ty. Fl:iiiilm:n: u.' this respo::iloility requires t'+:t the :•feoical Sc::ic:y respond to co:nments L`tat Fr,•i felt to b•a :nislcad17-.3 to thc public. llarvin C. Fiorcn;^!:i, M.D., Presidcrt. The itlediral Society o! t:.? District of Colu:tel:i.a. Jo!tu .`•I. }:cahiad.:n. M l)., Chairmvt, Public I::formati;ln and E<':lcation Colami:icc. P. Grr_; Gh,'dcs. Ni.!1. Chairman, ST,o'-:En; a:v3 Health Cxr•:,.fl:ac. , CTR HN 014'6't'~

L : ~' ..."~- iY.- 'eonard / L ry__IL PUBLIC RELATIONS COUNSEL - • /WIInV '` andAssociateAlnc. P. 0. BOX 523 • 13 LINCOLN ROAD • GREAT NECK. N.Y. 11021 • (212) 895•74a5 7HIS DOCUMEMT SUBJECT T February 24, 1971 IDOHf1DEHTIALITY AGREEMEN Dr. Sheldon C. Sommers Director of Laboratories Lenox Hill Hospital 100 East 77th Street New York, N.Y. 10021 Dear Charlie: As you will see from the enclosure, I had your letter from Zurich typed on CTR stationery and sent to the newspaper. Your letter had two minor errors of fact -- it was the Washington Star, not Post, and the officials were from the D.C. medical society. , / I recommended sending the letter precisely for the point you made -- that slience might indicate assent. Incidentally, I did not get a copy of the Star letter until yesterday. A copy is enclosed. Trust you and Edith had a wonderful time! With best wishes. Hope to see you soon. Sincerely, Leonard S. Zahn LSZ/hg cc: W.T. Hoyt Enclosures , 1 CTR ! !N 014GBO

THE COU\CIL FOR TOBaCCO RESL•'.iRCH-U.S.A., IsC. 110 EAST 50TH STREET NEW Yonh. v. Y.1oo_2 PflS DOCUMENT SUBJECT TO February 23, 1971 WNFlDEHTIAUTY AGREEMENT. The Editor Washington Star 225 Virginia Stxeet, S.E. wc~sliinyto:i, D.C. 20C03 Dear Sir: May I correct the statement of three officials of the Medical Society of the District of Columbia that by my not personally reviewing the Auerbach smoking dog material, in some way the claims made are supported. Simply stated, by premature publicity for their annual fund campaign the Cancer Society violated due scientific process and was thereby hurt. Failure of the J.A.M.A. to publish the study indicated seiious defects. Four investigators I respect who were close to the situation found no squamous lung carcinocr.a deronstrated. The evidence in the Dece:nber medical literature is unconvincing. No one is likely to use this experimental model again, since $750,000 was spent and zero squamous carcinomas can be accepted as produced. It is another of many experiments in which inhaled cigarette smoke did not produce cancer. Respectfully submitted, ~ Sheldon C. Somrners, M.D. Research Director SCS : ek 1 CTR HN 014681

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THIS DOCUMENT SUBJECT TO DONFIDEHTIALITY AGREEMENT. March 19, 1971 Dr. Harold L. Stewart National Institute of Health Building 37 Bethesda, Maryland Dear Dr. Stewart: J Thank you for your recent courtesy and the educational benefits of your company. Enclosed is the letter in Washington Star, Feb. 17, and my reply , of Feb. 23. My answer has not been published so far as I know. I will / allude to it or read it when giving a speech.to Mass. Medical Society on Quality Control in Cancer Pathology, early in June. Best wishes, Sheldon C. Sommers, M:D. SCS :dg (Encl.) . 1 Ct ~ ~N 014663

Tin: Cou::c;ij. F c,it';'oi;:~Lcco Tsc. 1l1J 2: AcT S9T:L \J•:%S' TCIa:. \. 1'. ] 00~ 3 Fehruary 23, 1971 THIS DOCUMENT SUBJECT TO OOMFlDENTIAUTY AGREEMENT. / The Editor 225 Vir-~ir.ia Street, S.E. Washington, D.C. 20003 Dear Sir: Hay I correct the stat::ment of three officials of the 1`ledical Society of the District of Columbia that by my not persorally reviewin; the Auerbach smoying dog material, in some ,aay, the clai.ms nade are suptor*_ed. Simply stated, by prematu=e publicity for their annual fund campaign t1he Cancer society violated due scier,ti.fic proc~:ss arid ~~as thereby hurt. Failure of the J.A.td.A. to publish the study indicated serious d2fects. FoL:r investigators I respect who were close to the situa ion found no squar;ous lung carcinoma der..or.strat:d. The evidence in the Dece'iaer mcdical literature is unconvincing. *Io one is likely to use this experimental moda?• again, since $75Z-11,000 was spent and zero squautous carcinomas can be accepted as produced. It is another of many ex7eri-:ents in which inhaled cigarette smoke did not produce cancer. Respectfully submitted, Sheldon C. Soc7,-..ers, M. D. Research Director SCS:ek , CTP MN 014664

/ 1~,Jsltittgtoit, U.C. Feb. 17, 1971 _ _ ~ ' P ~.~r n • ,sl ^a ~~+!~ ,~i~ t1;".y0 Lti1 a ,! L In to Jz-mus J.• I:il- p °': c:i:ich 1•z sa;;~ast:' t'•:t tb^ repc:ts by Drs. 0.:-r f.u.rb_ch rnd E. Cuyl,r Am-nntond, a•ao tt'::d Ct:t 1~.1 tt::-ecrs Ca:t r:•:d: fro:n c:r•r;:tt: S:cra r.at va!a. Addi;ic:i_I!;, ta ts s:..:a ttat:c:.:ts vrsicit cr: c::..:!i:11y L:ccaat: L`LLs tL-n; ;. :-.i C:: s_a'^ct of h::altii ii cen- C: . t• : c::a', r•,i C:g r: t•, t: c"taln that !}~: c~' ....., i.. :'.1 th:; h: L on: c: tha lar°c frur) cf I, cc-,t! "it"] to ~r•to':^ ^ e.rt•st th:a L..•~t:: som: bic :J i:r th!s r:C=rd. Cla c~.' •^ ~ C:s Ar^.c*iva l::aic;.l As:c:i_!lon, tho t!:o Dr. At:: •,ch to 1•_ crtr.in t: c.r Dr. Au_,bach sr.d Dr. Hcmmc^d ara rho havc pcr:ls:cd In h.:!r re:c:rch and td. :.'s• tho;ilic In th:ir fiad. :7c rcvlc~ccd i.!r. Kilpz!r.c.:'s artl:Ia c.•iati Dr. Au^rb:cit, wi:a tr,d!c at'] L•vat thrrc az:o ta•crel r^'nts aiilcir r::J:d cl--'•:•:L•i•;. • ,i•bi ,yar that Mr. hil i=tric'.: refcrrcd to raa F_hli.i::d ~~ t;ta "Archih•ea of +.:avironmeotal ><I:1'.th;' eit tr. "A:chives of h:nvL-c:::n_nt_l Ncdi- C:'n i.:0 CJr: L7 I7 t: S(!l:3tLlC Cf.:.tent o' rs a I,,:: Ro•_'., have r'.ae:•:1 in t:,y way t.!`': ti:. :estn!ctioi c::c;a to C:: 1: .::ican C:.*.ca- siha Nca En;::e•9 Jcu,ztal ct '•Icdicir.: has r:•~:t C: m,:: by all .•:C:o:s ar.J ra'!c'.:3's'•ty v::rc ur.::;! • to y::b'ath th+ --:iclzs submittcJ by Dr. :1v:•rt: ch b: aas: ihare h:.d b::n a prc-pu!o:(cati~n o: crrtain statisti^s and quotta•;at in th= >iec!ical 7`i':ene• a n°-s7cp:r•typs public:!ien 1= u•a c:r ^ t;~s'~• t) :`u T~u~, t~^~ could r.ct ~b: rcp'_b'.~::::d Li t'te i\c:: Enoland Journal of ?I•di:!;:s, r,t•icb cv, tcl::~i^:e s'.ard:rd p-ux3--e a;:.l by r.t: ~i, cf t:'• in ti;a vi_dic-l p:o- fcssier,, i:: Jcur.r1 00 the American 1ledieal Asso- el:::: i 4:3 r.ct rc;:ct ih: article submitted by Dr. :-.f Dr. IIammord, but s•j,;;ested raa&tn; ac:nt c' C:o rro:dln ; t:Ai at rtibjtir. ; bleck Gr.d ~hite prL:!a c! G: r c!':1:~. Auc.-t_ch ar3 Iiammoild •tl:•~ c.d c. vcly 2 ti:: pap:r, bit rat'.:•r than ~ In any w:.y,, r:7t ~t'd p:r• rl `: t atl .,th=r :1 a. 1!::t t~~r.trz:t Ci) p•-•r so th:t it co•] t::en be p~_';~• :d in ar.ethc• /..'.A pubflc2`!:a, t}a Arc:dves ot i:: :.-onraa!s{ 'ihls rc;crt, wn!cn :a goatly d::ea :d tha iob_:c ~ Laih t:, ~re•.•ed in c:sance that lun; ccu'.1 Ae devc.:,'sd by •sntc•:ang lahoratoq zi.:ri•!s. Proct Iar::^fore Atf~:•j -!t 11 h2d lt= t:ea t:at stno`:Lng ~d t.: s a rdsc :^~ :i; ~t•a lur.J c:.-^^r, w pxo: had b!.... ;: ezistcj. 1::: ic5s:co Ir.:ate`.^ f,•rti::r bad t - :9 t it t:::1 ~-:re si:a a raaio_sT•.ip it tha at. 1" i dernoas:r. t::i Lt the 1_':oratory ..r.imnl lirst. Af: :' t rejvrt arzs e•:t, tt•s 1 r.:a::.::n C^.zc:r Sccic:y tc'r. .:.d t'•: t. -J ct a.*.3 F:za: _on.d and acc :d tk::a F.bl::'.y c•t 5, i'70. V : ' _..... . . .' ..._ :~•. 4 , THIS DOCUMENT SUBJECT TO DOMFlDENTIAUTY AGREEMENT. ' Betore s1:L•l.tittin~ t,:~i: repcrt, Au,,b:ch ac•] 'r'.art- mn,:d tl.:o s!:iRcd ti,c:: tLT!!-'1 to n ct w110 f.1::~:.Ca (ia thiey COu!;1 *.9: h:.v2 s•:at::, ar• o:, kis C'cc c: c.t ;:is i icr::cc; :-t y: i! t:.m'.a. Any c~t`~ioJ: t c: u:zr.;ist t:, i.v: -:ira 0 ii>'.t h1s 1-`_:..aC:y a_r,d rt:ieu; ta;,ns F•itit h?-tt. On.'•'..:3 1~", ,,, %•:r.`. _ I•:'-_,,, :...,;i C. .°: :.'-,•.s, tha m :l-.~-d s' tit:. c r: . cf tl:: ^.cb,c,). T:_ :rch hiLt tr+ V~:-i; i,ia laL+:ctc:y r:r.j r:v:aw ll:: s:c':cns v,i~L hi ;t if he t:ica^u :•xu •-; vas cct c: t~a cou•'.ry, .c-T.:d tr. =: AeNI~_;, lr:w a.rd n:-tcd tl'a: t' n r.d tho;c slaad L•a oti;::; prc": _:.:a. K, v:,,-jid co:,t:ct him c-, his .cturn. 1:ca Yinst pby:ici-r.; tr ! ttv:.;-e c: Aue:b:cii :.'-. iic3 tr] rCCO;,71L: tL:ir v:!!ai:y. ia a vt:y' . su, ;stioa t;i^t t:nc::L^; i.; cn; ol tt:a ntc-! i,..; .:nc fr.acrs In t::: cau::,t:os c! lur•J Wrnors In r~a. A!• tF,ouZh cc a!l L•r:ca of p:::oa cno Lav: srao:::' --:st of their Iiv:.; vit3t r.o d:~:: nrn:at of luag cac:.:ra, It's crtirely p:abl: t!i:•t :: r::.dil:ction tor h:r.; c:r.:;r mcy'Z;a trr-;;_rcd by t::^:.cco smc:<e. 17e d:::'t yct Ynoa ahs,t 16 ti:=t r:a thA3 horribl: ch--in• c: ;:znts on its way. . As:ecla't; Wf!1: 0'+.cr Dis_ases • But th^ra's ztora. 17bct Mr. K!!patric; b:sn't re- partcl is that ciJar:tte s:.tolin; is cot wily a Fat:itial :cu:,a oi hu:r.ar. 1!u-, c:_%:r, u•jt it i; actually a:zoa• atcd )-i!h c'h:•r di: tcs. Ti:; S :;,~ Gc.^.:ral, t•rho li:a s~; c rt ~ Aue:ba:ii's Cc:d•u,_ : rc• Cc:.aY C?I':1 tl'.3 TO!']CCO to t2:G f^r l::1l!La m!sl:^Jin;, ress;utino ststor.:ents to s:ao:un; prc_:an: •-Ce th~t :-.. ;- v7C•i to• tl:. Fi:;~.7?nt iit:il:.°r a..^.] L.. c• t• Ss i.l ; ~ F:bllc La*7 (Fr; E':!3) o' A?rill, 1~-:', :`''±; th::t ell cl-: rct!) shall c^rry c:. :?: ^s y:LitLt, ~~~;_:;iLng 'i:nS•smo'ci:nJ Is dzn•+:ra_; ta t:.t l::ath. 1~1 Sur; r.n Ger.cial ~•:s c; :a ru3- aa.t:d ti•:; :.ez: btg t: t7v.;'ch:t:a ezd to r:ad: "1'Jarnir.g, Cimorette Smo!<iaS Is Dan,,:rou to He21t;t and ?.Iay Caua: Daath From Cancer, Coron:.ry Il:7rt Dis^ase, Chronic Erc::c:titis, Pulmonary Ernphy s:r•.ta a nd Other DL-cascs." This is the oth?r tniYortant material that \ir. Kill•atrictc ovcrloo'icd. . Cigaretta sui:1•i;,3 L prubaoiy t;:: sir.;l: g..,ieat cau:e Ic: em- jhy::ms. Alon; a•Ith th::; other discases. cmph!;::ma b of tha mc:t c;i; pling diseac; i no%s-n to mar'ar.d. In many insta.^.c:., eessation of smc!cinL,, has t3eo b:-eficIal to thc:; cuf::rin; from those disc2s:3. A respomiMity of the Medical Society is to :--te- guard the haalth of our contmunity. Fulfillment of this res,?r.sibility requires that the SIedical Sxiety respond to commcnts that arc felt to be. misleads; to the pub!ic. liarvia C. korcn;olJ, 11.D., Presid;nt, The Medical Sxicty of the D'utrict of Colu: ,:;a. Ja':n M. 1;eshlsbi:n, S1.D., Chai.-man, Public Ir.tormation acd Educa!iot Co-.rn:ittca. • P. Gres; T.So3:i. `•i.D. Chairman, Smo:3n; and Health Comniict::. \ , i E.r ! R ! ! 1 "t t..r 1`.'r 665'

TFrr•. Cov.cIc, Tocs Toi;.,Lcco RESLAacu-t.S.A., I.c. 110 EAST 3UTH tiTRF.FT NEW YoRt;... Y.1oo2a 1}IIS DOCUMENT SUBJECT TO Wt'IFIDEHTIALITY AGREEMENT. The Honorable Frank E. Moss Chairman, Subcocamittee for Consuners United States Senate Washington, D.C. 20510 My dear Senator Moss: Since returning fron vacation I have th:ougit how best to respond to the questions attached to your letter o: February 23. ':':ere are certain typing and other errors in the q,.;estio :s, but I will att:-_Dt to be responsive to what is believed intended. To avoid confusion, _ have reproduced each question by photocopy imr•,e3ia-tely preceding .;,,v answer. .1. - In your testirr.ony you suggc!sted that there is a serious scientific bias which enters into edir:cological c-0;1parisons bet;reen smokers and non-sr.okori. You indicute tha:t r,:; ..._-the:Tatics exists fcr statistical comparisons of random selected p,;,ul,:!{ions and that peoeple self-select %•.d:ether to s..o~e or not; thus the pcp°ulations studied are r;,t random. I think both of t1hese assertions can be put together to ask you the question, even if cigarette sco'll-ing werz not a health hazard do yc:r agree that epider..^ological data shovrs a greater *"cidence of prE-at;;re death and disability among those who sr::o:e cie:-re:tes than aTong those ;;^o do not sooke cigarettes? PreTature death does not mean an,vt~-,in.^ to ne eYce^t r.c=s':;1•: the death of a orenatt:relv born orc_anisa. ^he so-_allea cc'.:ort c_~^~ ~-_-ent obser•:ed egidemiolouicall;• in cigarette s okers az,. =ars to be a sta_'_: __=~1 artifact representing. chanciag ;cpsiation habi_s •Y:=h *_ime now desi;r.ata4 a secularity factor. The ^atter is considered at crE-:ter length ir. t:-.e 4 anal;:sis of the 1959 caper of Cornfield et al., ...._:h vo•a r=i-_este-r. finding probably has no.healtn signi°icance, an: once it bece,.es ~ to be a source of error it will lose ._n.i Dractic3l e:)i:3c^:iolegic val::-o. 1 CTR HN 014666

2 THIS DOCUMENT SUBJECT TO COHFIDENTIAUTY AGREEMENT. 2. Even if cigarette smoking does not ee"--se disease do you believe there is data to support a dose response relati=sF,ip indicating that t`,os who sma:e highe r tar and nicotine c,isarettes se e= to get the diseases attributed to smoking earlier and die earlier irs life than those who s-o~e i 1 lower tar and nicotine cigarettes. The matter of cose-response clri:as rela ~ing cigarette smoking to disease was discu;sed at length at a neetino ;r the Subcor.mittee of t_'le Joint Ccr.mittee on Tobacco and ::ea1=z. There se=:..-a-d to be agreement t::at dose-res: onse was a c=cper tern when applied to -fa..rious physiological and biochemical events, like heart rate and oxygen =er_s::n;tion, but that tne term could not oro=erly be arplied to disease endr:oints. In other words, dose-response is a misused tem in this context. If you simply -ean that people who smok:e higher tar and nicotine cigarettes are supposed to get diseases and die e,--rlier than those ::ho smoke cigarettes with lower -sr and nicotine, I know of no data that demonstrate such a relation conviningly. The orelininary ser ::~rts coroaring filter a nd nonfilter cigarettes do not permit any definite cc.-iclusions. 3. Do you believe there is a suitAble bio =assay model for lung inhalation studies? At oresent a C=R-devcloped inhaiati:n _=st system involvir.g smokir.g ^achines an3 la:>orstory animals is u::aergoina testir.g both and from the : ie'.:coint O: 2ngi.^.ee=i.^.g cS1a=a_-=e::5 t_ __::. : t i s tacu^• ^'_ the best yet achieved, but at least t,::o additic:::.l ns•:r -.sc'.:inc ^ocels are becoming available as prototypes. Their suit3:.ilit'1 :.e':e.^.ds c:1 the .^.ee':s of the individual investigator. '•iy oginion is that t:ere is still =ensic:e_a:r,le room for i-+proversent, b a that fresh ~•:hole cigarette s-sot:e car. no:.: be delivered to the resoiratorv tract of animals in a^.anr:er si:;ilar to that of human s-^okers. As to :,iaassay, the usefulness de_^=.^.cs on what it is desired to assay. CT~' HN 014687"

!'N1S DOCUMENT SUBJECT TO ~ 3 - pOMFlDEMIAtJTY AGRE&f. Wmen you riere being questioned by S..3tor Cook on Thursday, you eitcd a study by Keyes in the 1971 Surgeort ~-,zn=ra1's•report ard s`.at: that on page 39, "in discussing the monograph z1L- says that s,..;,kiny ;ras not considered in the t:.ro Jap~nese pc?.ulations.." I have read and reread page 39 and cannot find the statement :-rhich your (cited. Could you rir.;.oir, more precisely the statc.;:cnts location? Page 39, t!ealth Consequences of Snokinar, 1971, next to last line, beginning two words :ron end of line: "(:=o:~ng was not considered _.n the two Jaoanese cooulaticns.)" 5. Would you sup ply o;aissions and errors in the 1971 report to / 1 the Congress on the Health Consequences of S-.ok z ng? A compilation of the nunerous oaissicn4 and errors found in t::e 1971 F.eFort could be sought from The Tobacco Inst:tute. Tnis or?anizat:orn previously provided an evaluation'o_° the 1967 Repc_t, included in the record of the 1969 :(ouse Coc.merce Co-:Attee Hearings, ?art 2, p. 686 et seq. :;e library work involved is too much for my own sec=ctaries to har.dle. validity of scientific studies? 6. In relation to your co-:r:ent about th= snoking dog studies in response to a question from Senator Cook, you st3t_d "he has refused to permit his microscopic slides to be examir,dd by zn indpendent panel." Are rzvie-,rs by inicpcndent panels the usual proccd:.ire for evaluating the The reason an indeaendent pane1 to re-view the srol:ir.g beagle dog material was suggested was because of the unusual •.:a.i the i.^.:c_--.a=ion was oresented. You will recall a cress conference :.!as given, fn1_e,•ie'_ by widespread articlea in ne•tisra^ers and r•,agazin es. Then the :'e:.r Englan: Journal cf ':edicine decl'_neei to ^u...lish the article(s). Chern the of the Americ3n :•ledical AsGociati=r., after review by a large par.el of referees, declined to -u!^lish the articles. These events becac•e czblic knowledge, in part through an•article in The Wall Street Journal. The situation now aoneared curious. A great medical discovery was clained, but t•.:o res=ect=a medical Journals ..csld not pa.5lish it. ? Are they biased agair.s: t`. : inve:tlqatnrj? Are the clsi:;s :-.ade r.ot substantiated? ':hat has gor;e ••:rcn?? In such cir:•-:.stsnces, when the rlt'terican C.1.'icer S:ciet,' was calling on the tcb.~lcco co^p3nies to change t::?:: business an: the s?cke:,.^.an _;r the cor.,_:~anies •.:a.; c311ing or. the Cancer -cc'_e_2 to release their un=u::is^e; ^aterial, to ask for the o: inicl o° _,n ur._-ia=~___, independent pal:ci sccn•4 rt?aso.*:2.ble. CT H~HN 014666

- a ~ THIS DOCUMENT SUBJECT TO DONFIDENTIAUTY AGREEMENT. 7. In cormt;enting on other scientists deF=ndancy on goverr.-ent funding, and their failure to appear before Cony:^ssional cc-:-nitt-~_s you stated:- "they have been prevented by their ad-in istrative supericrs frc7i / appearing under the belief that this would jec;.zr-.Jize their research support." As you :ca, any forn of interfereres t)r intimidation a . potential tiritress before a Cor~ressicral Co.~^-i:.~e~ is a violaticn o= Federal La:•r. Please supply th~: r.sn-:s and id=;,*.i =-fcs and any cir;-_-;:__..__s of which you are a,.:are of scientis:s ::Iko ha:•= b«.n so prevente~ superiors. These cases will be for:rarded to t^e %Justice --cr prosecution. (Of course, your identity will ba kept ccnfidentiel and t:,e facts you supply ari l l not ap, ear i n the hear ing r: cord i` you so d= s i re .} / I These events occurred, b: t I will r.ot ini tiate a,,,,-.?lair.=. .:e investigators would be hurt further, in a situaticr, where L=.eir rese~:ca findings are what.is most needed. =::e situation referred to is r.ot =n isolated one. See Science, 1971 (i;ec. 24), 174, 1306, "Apart from officials of the interviewed for this article asked that citing the risk of being denied funds, SVC?, their since, a1-•.cst all ..-~-e•s not ce °an:ic-:e`, as c-.e scie^::s= s___, ':he NCI has a historf of vir.dictiveness. " 8. You also stated that "there ,•:ere cxscs of articles cn varic::s aspects of smoking and health that have been in c-e case acc:pt=d r publication and then after a note from a fcr,:er S~r~ecn Ger:-%rai rejected by the journal." Please supply ic!:ntif}-lang infor-=ticn cl case. This event has actuallv : ee.^. inc1u":? `_1 =.__.. Scnoo:Lra3:er, 'A Students' Su=:i•ra1 'sn.a_', ' •.:._. __ : .._ •, .._ pp. 71-74. The author tells of his o,::n :rcrk in the s.^..cki^_ an.. ____ . being censored, and auotes the e.ii=or's ,._ *_o _::e ` the consecuences of having the Su: =ocn C-en_r :i r~a_e :n _::e an article critical of his ocsiticn. r CTR HN 014669

- 5 - ?NIS DOCUMENT SUBJECT TO CONFIDENTIALITY AGREEMENT. 9. During our qucstioning period following your testirony I asked you about the Subco:m::ittee of the %joint Conitte; on Smoking and Health. Y u stated "%:e could not reach agre?~ent with tn= representatives of ';I1( ~ on various parts of this decum=r, trt because..." rs n't it tr ue that the represent&t;v:; of ;IIH znd lti:;-E~= had reached agrcc,:.cnt zr.d it was the representativEs of the tobacco industry who could not agree with tl~e draf t / agreed upon by FJ!A-EAF and N;H? Different portions of the draft were assigned to dif_erer•t -e--'-ers of the Subcor.L:•ittee. neca•ise of their :articular areas of e:<; ert'_se, ::e A.'4A representatives reviewed cardiovascular diseases, and ez this sec*_'_=rn there was considerable agreement. The cancer sec=:en was reviewed representatives, and no agreement was reached. The A:•±; represe.^.ta=i•: =5 , being outside their fields of specialization, toot no side, but were •.:i1'_ir.c_ to agree with c~hat the NIH and CTR representatives decided ~.:Pon. These latter never agreed, because the ::IH izsisted on ::^c~ali:i=~ acce~ts-=e olf the proposition 'ttiat cigarettes cause cancer as providing _::e bas'_c frariework for considering gaps in knowledge. Incidentallv, there were representatives of the tobacco on the parent Committee, but there were none on the S::bcoa:.ittee. , i Cts Ri t1'1 01`Y G9ti+*

TNIS DOCUMENT SUBJECT TO tANFiDENTIAUTY AGREEANT, 10• During our questioning I asked you t.:5ether or not you wculd advise a colleague who care to you wanting to i:rio:-i your opinicn as to vrhether or not his patients should sroke. You responded that you do r.ot Prescribe and that you did not %.rant to advise Feople on this su5,;ect. - ~ Since you were currently in the role of advisir.9 the Congress I feel it imperative that we get an ans:;er fro1 you on this ratter. Partic::lzrly an answer to the statEr..=_nt that you r;;de "the-re is no serious sicni,°ic=-: he ith hazard to the person t:ho s-o'•:es in =__ration." :•;hat is ~::,~:r!t,: t'or the averase person? Is it in terms of quar.tity of cigarettes cer cay Or are there other para^:2ters you wish to use? On reading r.iy testir..cny given at the recent hearing, I t.i-_< this question was answered. ::oderation I believe to be a-.atter c_ philosophy, so:-eti^es called life style, and not amedical st:'aject or definable in scientific terms. Jefferson is .::oted as believir.? _::a: _.n philosophy and norals the opinicns of the plcw:..an and professor ::a•:e e;ual weight, an opinion I share. i 11. Would you agree with the state:.ent "th:!i•e is not r,o,,: scientific evidence to establish tf,at cigarette sr..oking ca:ises Yes, there is no,.: insu:ficient scie:,ti'ic evidence to that cigarette sroking causes disease. 1 I C.r ! R ! !N 014691

7 - THIS DOCUMENT SUBJECT TO CONflDENTIAUTY AGREEMENT. / 12. If the answer to the above question Ts yes, could you provide t~.= Corr.nittee the identity of 50 other pathologists in the United States rrho would agree with that statciment? (I do not ask this question facetiously; if the Congress, the Ar;erican people, and the va:st majority of the r:orld's scientific co7munity has bccn fooled on this qub stion, it is necessary for you and other respectcd rzn of science to ce7,e far;:ard and set us straicht.; This is difficult to acconplish, unless I were to conduct a• poll by mail or personal intervie,:rs. However, if v ' ou read the reccrd of the 1969 House Co%merce Co-:7ittee Hearings, catholcgi_=ts who testified to this effect included Drs. Victor B,.Lhler, arthur Furs:, :ailliam B. Ober, R. H. Rigdon, John P. Wyatt and Irving Zeidman. Statements were provided by Drs. H. Russell Fisher, Doris L. Herman, Cecile Le::chtenberger and Rudolf Leuchtenberger, Walter S. Priest and Lucio Severi. All those above are identified as pathologists or experi^ental patholc•3ists by training, practice or both. Eight are from the U.S., and all have scent years in the field of diseases claimed to be related to smoking. If time and funds permit, a further listing could be compiled, but a pertinent quotation from Dr. Ralph R. Stevens is: "Biologic phenomena cannot be determined in a democratic manner." At last week's oathology convention 4 of the 6 men sitting closest to me were smoking cigarettes and another cigars. Let us acnit that uncertainty and controversy in the field of s^akir.g and health are rPal, serious and that the basic questions remain unanswered. Attached also is a list of accroxinatei_i articles supplementing the approximately 1275 not cited in the various smcking and health recorts and foraarded with my letter to you of Xarch 14, 1972. :ty comments in that letter apply as well to this suoclemental list. Resoectfully submitted, Sheldon C. So^mers, M.D. Research Director SCS:ek att. I I Ct R F E N 014692

61C:..: SRS r KENN:TM mERI<ILL LYNCM, hlD., SC.D. LL.D. Cho;r,nem HOWA:J L ANDEAVONT, sC.D. RICHA.tD j. {1`lv, AID. ti+C K:EN CATTEII, TH.D., M.D. tFON O. JACOiSON, M.D. iAUI KOT1N,1.~D. ' CIARENCE COOK UTTIR SC.D. ILD. UTT. D. Sci.n/;fit D'u.dw STANLEY P. Ri1MANN, MA. SC.D. W I LLIAM f. RR EK riOiF, J R. M.D. EDWIN R. WIISON,: e4.D. RO6EtT C. HOCKfTT. IHA. ALOtiete sONltiAf D/f.dM J. MORRISON 9RADY, M.D. Aa.edete SoieAtiAe DiredN July 12, 1966 Dr. Sheldon C. Sommers Departraent of Pathology College of Physicians and Columbia University New York, New York . r Dear Doctor Sommers: Surgeons THIS DOCUMEHT SUBJECT TO CONFlDENTIAL(TY AGREEMENT. It was pi*easanc news to _earr. ac- cepted appoir.=e :z as a membzr of t:.a visory Board of the Coti:ncil for To:-.acco and I wish to personally welca;,.z you. ~ both personal and professional. = believe that this will be a sa;.isf - p=2asaat expe•r+ence, as well as one irn whic: you w_=_ helpful service. I know no group of hig:.e: ri.~a::zy, Anticipating the pleasure of seeing you az z:e September 17-18 meeting, if not before. Sincerely yours, ~: ~ . , _.. . . ~ . Konneth M. Lynch, M. D. ~ IQKL : j ch cc: Dr. C. C. Little , Mr. W. T. Hoyt t/' 1 CTR HN 014693 SCIE.\ TIFIC s3.DV^SORZ 3OA:.D TO TRY COV\CIL FOR TOBACCO REEEwRCS-L'.S.A, 688 Taif.n Ara7rOa. \sw Yoal[,.N.Y. lOOiT

., THIS DOCUMENT SUBJECT TO DONFIDENTUIUTY AGREEMENT. J:1y 15, 1cF,5 Sheldon C. So®oers, M.D. Professor of Pathology College of Ptysiciane and Surgeonr Coluobia University 99 Fort Washington Avenue 14ew York, riew York 10032 Dear poctor Socmers: FollowinE Dr. Lynch's letter to you of July 12, 1c,60, i rauld also like to express gratification on behalf of all of us in The Council for Tobacco Research - U.Q.A. that you have an-reed tc serve on the Scientific Advisory Board to The Council. Although you already know the members of the Board and many fundamental facts concerning it, I nevertheless want to explain to you that, in becomi,ng a member of the Board, you have the unqualified assurance of The Council that both the Scientific Advisor,r 9oa.rd and the Scientific Director have complete freed= in all phases of the:r work; ead that: 1. The tobacco industry recognizes the public interest can onl,y be served by an objective search f or the fects and the trLth; 2. ?:o industry restrictions of any description vi2-' be attached to money grants made for any research project; 3. Any scientist carrying on a research project finenced by industry funds vill be free to publish the results of his vork in accordance vith accepted str::uards in medical journals. I am also attaching an outline which was given to the present members of the Board at the time of its formation presenting pertinent facts relating to The Council, formerly the Tobacco Industry Research Coamittee. Because of the broad ia*lications and importance of the public haalth problem involved in this undertald.ng, yow efforts on the Scientific Advisory Board xill constitute a very real public service. Boreirer, membership on the Board sbould not consume any major part of your time. CTR- HN 014694

. Sheldon C. SonmoerE, M.D. 2 ]tllS DOCUMENT SUBJECT TO July 15, QONFIDENTIAUTY AGREEMENT. It'is the thought of The Council that it would be in order to reimburse you for traveling and other ex.ensc: aa' to pey a per diec fee of $150.00 in connection with attending neetinr,s asd any other time devoted to the vork of the Scientific Advisory Board. As Ir. Lynch has advised you, the next meeting of the Board is scheduled for September 17-18 in New York City. We sincerel„v hope that you vill be able to be present. Meemhile, if you have e.ny questions vhich you would like to have answered, or any aspects of our program vhich you wish to discuss, please lct :;-r ::n:.w. :::: aL best wishez, I tr Sincerely yours, . , T. Hoy, SrTH: e i, CTR HN 0 146 '~-

THIS DOCUMENT SUBJECT TO CONFlDENTIAUTY AGREEMENT. i &wcsd 8. A:rdarvoat, Sc.D. 8m Fu7burA Rwd B*tb&sda, atnr7lsad 20034 D..r AaQr: I+ sarw that Ton vil2 be gl•d to bser thrt Charlie Soritrs has agre.d to e.iv+t prrt-tiae ss Research Dirator of C= to dchSag , himsslt direct.llr trrilabl,e for coasaltrtioa to the stiff ot ?ik Comacil to bsip drwlop the pro®rrs of expRad.d aad b.ttar- orieat.d aativiti*s of that Brvvp. As Cbsslis is s senber of the SAB nnd of itt :ubcooa.ittee on PrWira Plaaalag, I tA stttr that w COn all s.m bar valnsbls to aess joiat efforts this nw relstiossship csa be. Ve bWe sooo to add a ftt11-tia. ilssoeiate F•ecesrch Director in the liw 7ork of'fics to b.lp to fiw siar. of Bob Floclce t t' s,VLace Lisesti's, Jotsa Tsisiabsr's ewd Jeel: Brr.ctY's tim for actiul field eoatnets is aad aoaitarisg o! Z'bs Coaacil's res.rrch progrea and, above a3.1, far visits to and persoaal coatacts with Sl.B nestbers betwen sretiaes. In this vv, we nops to be la ectiw tasch vitb ycstr i,d..s and sedrirs with a alaistia of iacoanaisact to 7M es the ar+ier phases of tbe prWr.u are developed. IAOkiag for+rnsd to s.eiag rron in 1te,y, I aee As .mr, C2ar+aace C. Li ttl.., S c. D. Scientific DL rectoT CCSrs sic (2he abos+. letter also sent to Drs. EiaS, Catt*il, ambner, Loa.li, I,gaeh and Rieaboff. ) bcc: Sheldon C. Sommers, M.D. Mr. Henry H. Remm RCS , y CTR HN 01469G

'1'iit: (AW::c';1.F()1;'1'M sArC(I 1:E.i:A ic(A 1-L.S.A.. I.c:. 7lu F..\.T :.l-,na .•i•v i:rr XF:%%• TOUK. N. 1". tu41212 / June 15, 1972 Sheldon C. Director of Linoratori.?s Iznox Nil.l t:ospital 100 East 77th S.treet New York, York 10rj21 Dear Charlie: THIS DOCUMENT SUBJECT TO GONFIDENTUIL.ITY AGREEMENT. You infor^ea me last Sunday of your decision to res:;^ as -kcsearch Direct.or of The Council for To'~a=co 6`^search - U.S.A., Inc. I can appr2ci:ta your desire to be relieved of thz cuties of ?esear=:: Director vhich have been far more da^.:7dizq and tire-cor.su.-i::~?, n; rtic::lar1v recently, than •;,ou had an;• reason to think they be. I shall b^, and I am c::rt.ti.nn that the c!e"•.`.er3 of The Cau..:__, the staff and the Scientific Advisory °oard will bu, forever to : ou for your %:•ise counsel, cood humor and •.:er:^ fri-?nd.siip y?3rs of se:"Jice as es`'arc:1 Director. YUu gave Lln:clf:sal;d of yol::" al'... ._t...":S arld sc'=Jej .:ell beyLne~.•d the call O'f du*'_'. ~..lL e";_ you a aebt of ;rati=ude that can never b_ caid. It is hear*_enir.a_ to kncw that you are to renain on _re ScicntiFic =dvisor-r coard and continue to be its Ch_:?rr.an to ser:'.= on the nlazning Ccr%ni ttee. You also have been qo::a cncu::'.i to o:'_tr t., ~ar____lar:. r.:ar:e ;•our services available to u.s for consultations, d-u__ng th=• period ..hen Dr. Gardner a:ill be orier.tin= himself to his r.s~: resconsibilities. We will certainly continue to necc: you in these various ca^acities and are thankful that your services will be avai:=:e.' Permit me to thank you again for all your help and _:our graciousness. I look forward to your continuing counsel and advice and your friendship. Most cordia112, H. (i . Ramm President e HHR: ek . CTR HN 0 1 469"Ir"

THE COC`CIL FOR TOBACCO RESEaRCH-L.S.a., I`C. THIS DOCUMENT SUBJECT TO ~ONEIDENTIAUIY AGREEMENT. June 15, 1972 MEMORANDUM TO: Zndustry Technical Committee FROM: H. H. Ramm, President Dr. William U. Gardner, about whom I wrote you last November when he became a member of The Council's Scientific Advisory Board,as anticipated, is to become Scientific Consultant to The Council as of July lst. Dr. Sheldon C. Sonaners has resigned as Research Director for The Council; however, he will remain a member of the Scientific Advisory Board and continue to act as its Chairman and to.serve on the Planning Committee. All of us owe a great deal to Dr. Sommers whose advice and counsel have been invaluable. When he agreed to serve for a short duration as Research Director he did not contemplate that the assiqnment would continue so long and demand so much of his time. During the next twelve months Dr. Gardner will devote approximately half of his time to The Council. After that we anticipate his appointment will be on a full-time basis. H. H. Ramm HHR:ek CTR HN 014698

I: ('tW N( 11.1"t11 ~ 'i"llli.%(.l•()j\t.-, I..%l;l I1,-~ .ti..~.~ I N(•. 1 J// .Il1711 NI'N% Yollli•N•~•J11f1-~ THIS DOCUMENT SUBJECT TO / Juno 15, 1972 Cll•::1?'l:ull bra-:d_. Inc. 243 rei ': At-:anuc .:C.. : Ork . ..: • : ork 10017 --a! Pa_r.^; . CONFlDEHTIALtTY AGREEMENT, Dr. ._11:a:^ U. Cc:r?r.er, about .:icm I w:•o:.e you 1a=_t ;. .`.~.r o.ha_ haca~e aof .`.c% Council's Sc:er.ti.:ic `.a;iscr _c.. -.s al:' i c:ra_e;i, is to bocene Sci.entific Consultant to :=e Co•.i::-i l as cf July 1st. D1:. 5.'.eld'Jn C. -iS =Cc-.-^.ed as 9rg.-.. c.n 'i=eCtOr COuRC:1; hC::eVe_'r, :.e 41111 _. sor and eo•^.tin•__ to tc*_ rs i=: Cha:=r^.::n ar..i to se:•c•e on ~ - O'.: a c r-~t c.Ca1 to D= . :,C.-._ -.n•- .. _~~ . _S :!~oSc nll o _ c?d•, lc= 3:d cOU7:S'E'1 have t1e~a 1rtC3iuz:-bie. ::.len ilc^. 3cTCca to .,.-r:'°_ fJr c'1 ',:,o-"t 6urc L]on aS Rbs°_2L.:1 Olrf:ct0r he did not cOI:tE!*sl:,i:: t!'.-t t"te COntir.L`C so long and d_.^..?1;1d so much of his t]r.C. n::rin ;; t.'Se next t•.ti fi1Ve I'ICntas i)r. . Cia.-dnC_ wi ll d: Vpt° ~r. : cxi;:atel;~ hal: o' his tirtie to The Council. ::fter that we anticin.r '-. a:-•:c'_ntTent will be on a full-tir.: basis. Sinc2rely yours, H. :'. . Ramn President I!t!P.: e}: (Tlie abO" 1atter a1.0 Nat tOt C'!R sponsOrs ' G.aaral C1oass.1 ltr. EasQp , CTR HN 014699

LE'NiTOX HILL HOSPITAL 100 EAST 77TH STREET / NEW YORK. N v. 10021 / TRAFALpAR f•1000 F"M.N IW THIS DOCUMENT SUBJECT TO OONFiDENTIAUTY AGREEMENT. June 27, 1972 Mr. H. H. Ramm Council for Tobacco Research 110 East 59th Street Nav York, N.Y. 10022 Dear Mr. Rame: Thank you iadeed for your nice letter at the end of my service as Research Director, Council for Tobacco Research. I did the best I could for as long as was possible, considering various other obligations. My belief is the scientific tide has turned, partly through the efforts of CTR, and with everybody's help there is reason to hope that be- fore too long we will know what really causes some of the diseases wrongly blamed on smoking. Best wishes, SCS/mop Sheldon C. Sommers, M.D. CTR HN 014700

YNIS DOCUMENT SUBJECT TO DONFIDEliTIALITY AGREEMENT. UmO,bO„dum PLOm . . • • ALlXANDER NOLTZl1AN a • - 1Y,/. /.l....: /. 11. , / / 1; /. / . , ' ~'' " ,* .a , ,1 CTR HN 0 14701

AN/FUJ Ai..[cK:,Aaa UecAt'1 February 25, 1970 Mr. William B. Lewis, Chairman of the Board American Cancer Society i 219 East 42nd Street New York New York 10017 FR{S DOCUMENT SUBJECT 10 , Dear Mr. Levis: 04MFlDE1iTIAtITY AGREEMENT, On February 5, Drs. Oscar Auerbach and E. Cuyler Hartmond presented to the press at a special meeting held in conjunction with the meeting of the American Cancer Society Board of Directors the findings of their study on "The Effects of Cigarette Smoking Upon Dogs." The American Cancer Society at that time issued a "Backgrounder" interpreting the results of the experiment as a significant achievement representing the first time that scientists have produced lung cancer in a large ex- perimental animal as a result of heavy smoking. The Cancer Society's release further claimed that these findings should have a significant impact on the smoking of cigarettes and on the advertising claims and policies of the cigarette industry. The report and these interpretive comments have been given wide publicity. As you may know, there have been previous studies with cigarette smoke in which the initial report has,claimed that lung cancer -- resembling lung cancer in humans -- was induced in experimental animals. These were i CTR 1 t1"t 014702

-2- AH/PDS ALTERNATE DRAFT THIS DOCUME1iT SUBJECT TO QONFIDENTIAUTY AGREEMENT, proved either wrong or of little significance after the results were subjected to rigorous scientific examination. Other developments in connection with smoking and health have sometimes been announced under impressive auspices such as a major university -- and, after evaluation, have been found to dis- appoint their sponsors. Since the American Cancer Society asserts that the present study is of considerable import to the tobacco industry, I believe that the industry is entitled to have a full understanding of the nature and significance of the findings as quickly as possible. In the interest of accomplishing this aim, I request that the American Cancer Society permit a thorough evaluation of the experiment and its results by.a panel of independent scientists with wide experience in areas relevant to the data. I propose that we proceed as follows: The American Cancer Society shall notify me whether they and the investigators will agree to permit access to the relevant materials and data by a panel of scientists. Upon being notified that the material will be made available, I shall nominate as reviewers several well known scientists highly qualified 1 CTR HN 014'~~~

AH1PDS ALTERNATE DRAFT -3- THIS DOCUMENT SUBJECT TO CONFIDENTIALITY AGREEMENT. in the fields of experimental work, tumor pathology and lung diseases, who, I believe, would be recognized by the Cancer Society and by their colleagues as men of outstanding competence and integrity. Naturally, none of these men will be connected with the tobacco industry. If the Cancer Society should, for good reason, reject any of the men whose.names I offer, I would appoint a substitute. The tobacco industry will, of course, bear all costs in connection with this review. I look forward to an early favorable response from you so that this work may cqmmence at the earliest possible date. ~ Yours very truly, Chairman of the Executive Committee, The,Tobacco Institute, Inc. 1 C`"R H~~ 01~~:''O-4