Tobacco Documents Online

CTR HN 01 1167

CURRICULUM VITAE Gordon Barry Pierce, Jr., M.D. Personal Statistics: Born July 21, 1925, Westlock, Alberta, Canada Married, 5 children Immigrant Visa, eligible U.S. citizenship Military Service: Canadian Army, 1943-45 Education: University of Alberta, 1950, M.Sc., Anatomy University of Alberta Faculty of Medicine, 1952, M.D. Interne, University of Alberta Hospital, 1952-53 Marine Biology Course, uood's Hole, Massachusetts, 1959 Professional Record: Licentiate, Medical CoJncil of Canada, 1953 Lecturer in Pathology, University of Alberta, 1953-55 Sarah Mellon Scaife Fellow in Pathology, University of Pittsburgh, 1955-59 Diplomate of the American Board of Pathology in Anatomic Pathology, 1957 Assistant Professor of Pathology, University of Pittsburgh, 1958-61 Associate Professor of Pathology, University of Michigan, 1961-64 American Cancer Society Professor of Pathology, University of Michigan, 1964-68 University of Colorado, 1977-present Professor and Chairman, Department of Pathology, University of Colorado Health Sciences Center, 1968-present Awards: Pope Memorial Gold Medal in Medicine, University of Alberta, 1952 Sarah Mellon Scaife Fellowship in Pathology, University of Pittsburgh, 1955-59 Markle Scholar in Medical Science, 1959-64 Guiteras Lecturer, American Urological Association, 1962 American Cancer Society Career Professorship, 1964-present Medical Alumnus of the Year Award, University of Alberta, 1968 McFarlane Visiting Professor of Medicine, University of Glasgow, Royal Infirmary, 1979. bS.Gl'i .,_47 CTR i i i i T 01116B

Society Memberships: American Society for Cell Biology American Association for Cancer Research American Association for the Advancement of Science American Association of Pathologists (President, 1977) Federation of American Societies for Experimental Biology (President, 1978) International Academy of Pathology Pluto Club Society for Developmental Biology International Society for Differentiation (President, 1978-present) American Pathology Chairmen Committees: Medical Scientist Training Committee, NIH, 1965-1968 Editorial Board, ~Labor~at~or! Investigation, 1967-1978 Editorial Board, Deve pmenta ~Moogy, 1968-1973 Editorial Board, ncer Research, 1970-1975; 1980-1984 Cell Biology Study ection 1968-1972 Pathology B Study Section, NIH, 1973-1977 American Cancer Society Committee on Personnel, 1968-1972 Chairman, Meritorious Awards Committee, American Society Experimental Pathology, 1969 and 1970 Program Committee, American Association for Cancer Research, 1973 and 1974 Councillor, American Society of Experimental Pathology, 1973 Secretary, American Society of Experimental Pathology, 1975 Member, Select Committee on Priorities and Planning, FASEB, 1974-1975 Director, Colorado Division, American Cancer Society, 1972-1978 Vice President, American Association of Pathologists, 1976 Treasurer, International Society of Differentiation, 1976-1978 President, International Society of Differentiation, 1978-present President, American Association of Pathologists, 1977 President, Federation of American Societies for Experimental Biology, 1978 Council of Scientific Society Presidents, 1978-present Board of Scientific Counselors, Division of Cancer Cause and Prevention of the National Cancer Institute, 1978-present Committee for Planning and Projection of the American Cancer Society, 1978-present 6:,10-1 __'yS CTR HN 011169

BIBLIOGRAPHY Gordon Barry Pierce, Jr., M.D. 1. Pierce, G. B. The Iron Content of Mammary Epithelium. Master's Thesis. University oM~erta `[ibrary, . 2. Rawlinson, H. E. and G. B. Pierce. Iron content as a quanti- tative measurement of the effect of previous pregnancies on the mammary glands of mice. Endocrinology 46: 426-433, 1950. - ' 3. Rawlinson, H. E. and G. B. Pierce. Visible intraepithelial iron in the mammary glands of various species. Science 117: 33-34, 1953. 4. Rawlinson, H. E. and G. B. Pierce. Differences in mammary gland development among different mouse strains as measured by the iron content of the gland. Proc. Amer. Assoc. Cancer Res. 12: 289, 1952. 5. Pierce, G. B., E. l. Verney and F. J. Dixon. The biology of testicular cancer. I. Behavior after transplantation. Cancer Res. 17: 134-138, 1957, and Proc. Amer. Assoc. Cancer Res. 2: 239,-T951. - . 6. Pi erce, G. R., F. J. Di xon and E. L. Verney. The bi ol ogy of testicular cancer. II. Endocrinology of transplanted tumors. Cancer Res. 18: 204-206, 1958. 7. Pierce, G. B. and F. J. Dixon. Testicular teratomas. I. The demonstration of teratogenesis by metamorphosis of multipotential cells. Cancer 12: 573, 1959, and Fed. Proc. 17: 453, 1958. 8. Pierce, G. B. and F. J. Dixon. Testicular teratomas. II. A teratocarcinoma as an ascites tumor. Cancer 12: 584-589, 1959. 9. Pierce, G. B., F. J. Dixon and E. L. Verney. Endocrine function of a heterotransplantable human embryonal carcinoma. Arch. Path. 67: 204, 1959, and Proc. Amer. Assoc. Cancer Res. 2: 33~, 1958. 10. Verney, E. L. and G. B. Pierce. The biology of testicu- lar tumors. III. Heterotransplanted choriocarcinoma. Cancer Res. 19: 633, 1959. 11. Midgley, A. R., G. 3. Pierce and F. J. Dixon. The nature of colchicine resistance of the golden hamster. Science 13,3: 12. 40-41, 1959, and Fed. Proc. 18: 495, 1959. Pierce, G. B., F. J. Dixon and E. L. Verney. An ovarian teratocarcinoma as an ascitic tumor. Cancer Res. 20: 106-111, 1960, and Proc. Amer. Assoc. Cancer Res. 51-52, -T 1959. _ CTR HN 0 111 't''o

13. Pierce, G. B. Choriocarcinoma of the testis: Discussion of paper. Ann. N.Y. Acad. Sci. 80: 174-177, 1959. 14. Pierce, G. B., F. J. Dixon and E. L. Verney. Terato- carcinogenic and tissue forming potentials of the cell types comprising neoplastic embryoid bodies. Lab. Invest. 9: 583-602, 1960, and Proc. Amer. Assoc. Cancer Res. 3: T41, 1960. 15. Pierce, G. B., F. J. Dixon and E. L. •Verney. A critical evaluation of furacin as an anti-testicular tumor agent. Urology 84: 569-574, 1960. ' 16. Pierce, G. B. Teratocarcinomas. A Problem in Develop- mental Biology. ourt na ian Cancer nference TT._Te_gg, e., Vol. 4. Academic Press, New York, 1961, pp. 119 137. .17. Pierce, G. B. and E. L. Verney. An in vitro and in vivo study of differentiation in teratocancinomas. Cancer T4: 1017-1029, 1961, and Fed. Proc. 19: 247, 1960. 18. Midgley, A. R. and G. B. Pierce. Effect of colchicine and x-irradiation on the differentiation of human embryonal carcinoma. Cancer Res. 21: 545-549, 1961, and Proc. Amer. Assoc. Cancer Res. 3:- 13T,- 1960. 19. Midgley, A. R., G. B. Pierce and W. 0. Weigle. Immuno- biological identification of human chorionic gonadotropin. Proc. Soc. Exp. 8iol. Med. 108: 85-89, 1961. 20. Pierce, G. B., A. R. Midgley and E. L. Verney. Therapy of heterotransplanted choriocarcinoma. Cancer Res. 22: 563-55', 1962. 21. Midgley, A. R. and G. B. Pierce. Immunohistochemical localin zation of human chorionic gonadotropin. J. Exp. Med. 115: 289-294, 1962, and Fed. Proc. 21: 198, 1962. 22. Pierce, G. B., A. R. Midgley, J. D. Feldman and J. Sri Ram. Parietal yolk sac carcinoma. Clue to the histogenesis of Reichert's membrane of the mouse embryo. Amer. J. Path. 41: 549-566, 1962. 23. Kleinsmith, L. J., G. B. Pierce and A. R. Midgley. Nephrotoxic roles of antibodies against endothelial and epithelial components of glomerular basement membrane. Fed. Proc. 22: 256, 1963. 24. Pierce, G. B., A. R. Midgley and J. Sri Ram. The histo- genesis of basement membranes. J. Exp. Med. 117: 339-348, 1963, and Fed. Proc. 22: 256, 1963. -. .` t ~!(3 e C 2 ` C 1s~ 11-11 N 0 1117"' 1

37. Totten, R. S. and G. B. Pierce, Jr. Cortisone and atypical pulmonary "epithelial" hyperplasia: Further studies including electron microscopy, tissue culture, animal trans- plantation, and long-term observation. Amer. J. Path. 45: 977-990, 1964. 38. Beals, T. F., G. B. Pierce and C. F. Schroeder. The ultra- structure of human testicular tumors. I. Interstitial cell tumors. J. Urol. 93: 64-73, 1965. 39. Pierce, G. B. and J. Sri Ram. The localization of epithelial basement membrane antigen in the kidney of the mouse. Fed. Proc. 24: 434, 1965. 40. Mukerjee, H., J. Sri Ram and 6. B. Pierce. Basement membranes. V. Chemical composition of neoplastic basement membrane mucoprotein. Amer. J. Path. 46: 4957, 1965, and Fed. Proc. 23: 235, 1964. 41. Pierce, G. B. Basement membranes. VI. Synthesis by epithelial tumors of the mouse. Cancer Res. 25: 656-669, 1965. 42. Pierce, G. B. The development of basement membranes of the mouse embryo. Dev. Biol. 13: 231-249, 1966, and Fed. Proc. 25: 355, 1966. 43. Pierce, G. B. Ultrastructure of human testicular tumors. Cancer 19: 1963-1983, 1966. 44. Sri Ram, J., P. K. Nakane, D. G. Rawlinson and G. B. Pierce. Enzyme-labeled antibodies for ultrastructural studies. Fed. Proc. 25: 732, 1966. 45. Nakane, P. K. and G. B. Pierce. Enzyme-labeled antibody for the light and electron microscopic localization of tissue antigens. J. Cel1 Biol. 33: 307-318, 1967. 46. Nakane, P. K. and G. B. Pierce. Enzyme-labeled anti- bodies: Preparation and application for the localization of antigens. J. Histochem. Cytochem 14: 929-931, 1966. 47. Pierce, G. B. Teratocarcinoma: hbdel for a Developmental Concept of Cancer. In: Current Topics in Develoomental Biology (A. A. Moscona an~t~onroy, eds.), Vo .. caic Press, New York, 1967, pp. 223-246. 48. Pierce, G. B. and P. K. Nakane. Nuclear sex of testicular teratomas of infants. Nature 214: 820-821, 1967. 49. Pierce, G. 8., L. C. Stevens and P. K. Nakane. Ultra- structural analysis of the early development of terato- carcinomas. J. Nat. Cancer Inst. 39: 755-773, 1967. 65:00 62-52 CTR_ ~N 01 1 1~~~

50. Pierce, G. B. and P. K. Nakane. Antigens of epithelial base- ment membranes of mouse, rat and man: A study utilizing enzyme-labeled antibody. Lab. Invest. 17: 499-514, 1967. 51. El-Bolkainy, M. N., G. B. Pierce, Jr. and A. J. French. Regression of an adrenal cortical carcinoma by estradiol treatment. Cancer Res. 27: 1846-1854, 1967. 52. Pierce, G. B. and P. K. Nakane. Basement membrane: Synthesis and deposition in response to cellular injury. Lab. Invest. 21: 27-41, 1969, and Fed. Proc. 27: 411, 1968. - - 53. Lee, P. A., K. Blasey, I. J. Goldstein and G. B. Pierce. Basement membrane: Carbohydrates and x-ray diffraction. Exp. Molec. Path. 10: 323-330, 1969. 54. Perez-Palacios, G., K. G. Lamont, A. A. Perez, R. B. Jaffe and G. B. Pierce. De novo formation and metabolism of steroid hormones in_Teminizing testes. J. Clin. Endocr. Metab. 29: 786-800, 1969. 55. Pierce, G. B. Differentiation of normal and malignant cells. Fed. Proc. 29: 1248-1254, 1970. 56. Pierce, G. B., W. K. Bullock and R. W. Huntington. Yolk sac tumors of testis. Canc@r 25: 644-658, 1970. 57. Pierce, G. B. and M. R. Abell. Embryonal carcinoma of the testis. In: Pathology Annual (S. C. Sommers, ed.), Vol. :. Appleton-Century_ rofts, New York, 1970, pp. 27-60. 58. Pierce, G. B. The origin of basement membrane. In: Advances in Biology of Skin. The Dermis (W. Montagna, J. P. Wntley and R . L.-1Ri_Dson, eds. , ol. X. Appleton- Century-Crofts, New York, 1970, pp. 173-194. 59. Johnson, L. D. and G. B. Pierce. Changes in antigenicity of basement membrane during wound healing. Dev. Biol. 23: 534-549, 1970. 60. Pierce, G. B. Hyalogenic (basement membrane-forming) tumors. In: Chemical Tumor Problems (W. Nakahara, ed.). Japanese Society ror the_Promotion oT Science, Tokyo, 1970, pp. 139-154. 61. Pierce, G. B. Epithelial basement membrane: Origin, development and role in disease. In: Chemistry and Biology of the Intercellular Matrix (E._T.__Fa7azs, ed.), V-o'T 1. -Acaaemic Press, New Yok,1 970, pp. 471-506. 62. Pierce, G. B. and C. Wallace. Differentiation of malignant to benign cells. Cancer Res. 31: 127-134, 1971. CTR HN 011173 3

63. Pierce, G. B. and C. Wallace. Differentiation and cancer. In: Oncology 1970. Proceedings of Tenth International Cancer Congress, R. L. Clark et al., eds.), Vol. 1. Year Book Medical Publishers, Inc.,7hicago, 1971, pp. 536-542. 64. Pierce, G. B. and L. D. Johnson. Differentiation and cancer. In Vitro 7: 140-145, 1971. 65. Martinez-Hernandez, A., P. K. Nakane and G. B. Pierce. The secretory granules of the acinar cells of the mouse submaxil- lary gland. Amer. J. Anat. 133: 259-267, 1972. 66. Pierce, G. B. Microscopic diagnosis of eight testicular tumors. Resident and Staff Physician, April, 1972. 67. Pierce, G. B. Differentiation and Cancer. In: Cell Differentiation (R. Harris, P. Allin and D. Viza, eds.). Munksgaard, Denmark, 1972, pp. 109-114. 68. Wylie, C. V., P. K. Nakane and G. B. Pierce. Degrees of differentiation in nonproliferating cells of mammary carcinoma. Differentiation 1: 11-20, 1973. 69. Martinez-Hernandez, A., P. K. Nakane and G. B. Pierce. Relationship between the submaxillary gland and the thymus. Lab. Invest. 29: 266-271, 1973. 70. Pierce, G. B. Cellular heterogeneity of cancers. In: Chemical Carcinogenesis: Part B (P. 0. P. Ts'o and J..- DiPaolo, eas. . Marcel-Dekker, Inc., New York, 1974. 71. Pierce, G. B. The benign cells of malignant tumors. In: DeveloDmental AsDects of Carcinogenesis and Immunity, 32nd ymposium o tne c1eiy or eve opmentaTBio'Togy. A aeen~ Press, New York, 1974, pp. 3-22. 72. Pierce, G. B., P. K. Nakane and J. E. t4azurkiewicz. Natura; History of Malignant Stem Cells. Proceedings of the t~ nternationa ymposium of^TFe_Princess Takamatsu Cancer Research Fund, Tokyo, 1973 (W. Nakahara, T. Ono, T. Suginura and H. Sugano, eds.). University of Tokyo Press, 1974, pp. 453-469. 73. Lehman, J. M., W. C. Speers, D. E. Swartzendruber, and G. B. Pierce. Neoplastic differentiation: Characteristics of cell lines derived from a murine teratocarcinoma. J. Cell Physiol. 84: 13-28, 1974. 74. Martinez-Hernandez, A., P. K. Nakane and G. B. Pierce. Intracellular localization of basement membrane antigen in parietal yolk sac cells. Amer. J. Path. 76: 549-556, 1974. _=:©C c:=4 C TR HN 0111r'A

75. Pierce, G. B. Neoplasms, differentiations and mutations. Amer. J. Path. 77: 103-118, 1974. 76. Pierce, G. B. Nonproliferating Cells of tumors. In: Comparative Leukemia Research 1973, Leukemogenesis.(Y. Ito and R. M, Dutc, eds. . University of Tokyo Press, Tokyo/Karger, Basel, 1975, pp. 271-272, 1975. 77. Pierce, G. B. Teratocarcinoma: Introduction and perspec- tives. In: Teratomas and Differentiation (M. I. Sherman and D. Solter, eds. . Acade im Press, New Yor , 1975, pp. 3-12. 78. Pierce, G. B. and R. H. Fennell, Jr. Latent Carcinoma and Carcinoma in Situ. Presented at the Conference on Spontaneous Regression of Cancer, The Johns Hopkins Medical Institutions, Baltimore, Md., May 9-10, 1974. Nat. Cancer Inst. Monogr. 44: 99-102, 1976. 79. Martinez-Hernandez, A., L. M. Fink and G. B. Pierce. Removal of basement membrane in the involuting breast. Lab. Invest. 34: 455-462, 1976. 80. Pierce, G. B. Origin of neoplastic stem cells. In: Progress in Differentiation Research, 2nd International o~ n e~rerice on i erentiation, open agen, Denmark, September 8-12, 1975 (N. Muller-Berat et al., ed.). North- Holland Publishing Company, amsterdam,-The Netherlands, 1976, pp. 269-273. 81. Nogales-Fernandez, F., S. G. Silverberg, P. A. Bloustein, A. Martinez-Hernandez, and G. Barry Pierce. Yolk sac carcinoma (endocermal sinus tumor). _ Ultrastructure and histogenesis of gonadal and extragonadal tumors in compariscn with normal human yolk sac. Cancer 39: 1462-1474, 1977. 82. Pierce, G. B., P. K. Nakane, A. Martinez-Hernandez and J. M. Ward. Ultrastructural comparison of differentiation of stem cells of murine adenocarcinomas of colon and breast with their normal counterparts. J. Nat. Cancer Inst. 58: 1329-1345, 1977. 83. Pierce, G. B. Neoplastic stem cells. Symposium on "Differentiation and Carcinogenesis," Given Institute of Pathobiology, Aspen, Colorado, August 15-20, 1976. In: Advances in Pathobiology. Cancer Biology IV. C. Borek, C. M. Fenoglio and D. W. King, eds. Stratton Intercontinental Medical Book Corp., New York, 1977, pp. 141-152. 84. Pierce, G. B. Relationship between differentiation and carcinogenesis. J. Toxicol. Environ. Health 2: 1335-1342, 1977. C TR' H N 0 111 'e' " r'

85. Pierce, G. B., R. H. Shikes and L. M. Fink. Cancer: A problem of Developmental Biology. Prentice-HaTl, Inc., ng ewooU_C i s, New JerseT18. 86. Pierce, G. B. and W. F. Cox, Jr. Neoplasms as caricatures of tissue renewal. Proceedings of 30th Annual Symposium on Fundamental Cancer Research. In: Cell Differentiation and Neoplasia (G. F. Saunders, ed.). Raven Press, New Yor-Tc,- TT7T, -pp. 57-66. 87. Pierce, G. B., S. H. Lewis, G. J. Miller, E. Moritz, and P. Miller. Tumorigenicity of embryonal carcinoma as an assay.to study control of malignancy by the murine blasto- cyst. Proc. Nat. Acad. Sci. USA 76: 6649-6651, 1979. 88. Pierce, G. B. and R. H. Fennell, Jr. Pathology. In: Cancer Medicine (J. F. Holland and E. Freii, III, eds.), 2na . Lea and Febiger, Washington Square, Philadelphia, in press, 1980. 89. Pierce, G. B. Teratocarcinoma. In: Cancer Markers: Developmental and Diagnostic Significance Stewart Sell, ed. , Humana Press, nc., i ton, N.J., 1980, pp. 1-36. 90. Pierce, G. B., C. Pantanzis, J. E. Caldwell and R. S. Wells. Embryologic control of malignancy. Proceedings of the ICN- UCLA Symposia, Keystone, Colorado, 1981. In: t4echanisms of Chemical Carcinogenesis (Curtis Harris, Peter Cerutti, organizers . In press, 1981. 91. Cox, W. F., Jr. and G. B. Pierce. The endodermal origin of the endocrine cells of an adenocarcinoma of the colon of the rat. Cancer, in press, 1982. 92. Pierce, G. B., C. Pantazis, J. E. Caldwell and R. S. Wells. Specificity of the control of tumor formation by the blasto- cyst. Cancer Research, in press, 1982. 93. Pierce, G. B., A. Jones, N. G. Orfanakis, P. K. Nakane, L. Lustig and A. Martinez-Hernandez. Biosynthesis of base- ment membrane by parietal yolk sac cells. Differentiation, in press, 1982. 94. Pierce, G. B. and R. S. Wells. Embryologic Microenvironment in Regulation of Cancer. Proceedings of 4th Annual Bristol Meyers Symposium on Cancer Research, Baltimore, Maryland, 1981. In: Embryonic Development (A.H. Owens, ed.), in press, 19 . c5_f?P c: =; l.y ! R E ! t `t 01.E 1iyG