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CTR HN 0 11117

Cl,?RICIZ,L'a! VITAE DATE: Ph D M D d G d K _ . . ., . . son, ..., nu ,NA.kM: Alfre DATE OF BIRT'r': August 9, 1922 PLACE OF BIP.T'r.: MARITAL STATUS: Married, Anna T. Meadows, M.D. SOCIAL SEChP.ITY 'N0.: EDUCATION: ?.---_es, CA c.6"-2y-44b1 California Institute of Technology B.S 19•,-, Columbia University 1947 California Institute of Technology N•T>- 1956 TRAI\ING, NATIONAL SERVICE and BOARD CERTIFICATION: In•e-n, Huntington Memoria: Hospital, Pasadena -'4-;7-Y8 Assistant Resident in Pediatrics, New York Hospital Resident in Pediatrics, LosvAngeles Childrens Hospital Research Fellow, Los Angeles Childrens Hospital :5~0-01 Pediatrician (lst Lt., M.C.) U.S.A.H. Fort Riley, Kansas :y51-o3 Certified, American Board o' Pediatrics 1954 POSITIONS: City of Hope Medical Center i=56-1966 Chairman, Department of Pediatrics (1956-1962) Chairman, Department of Biology (1962-1966) State University of New York at Stony Brook, Health Sciences Center :565-196y Associate Dean (for Basic Sciences) and Professor of Pediatrics Universitv of Texas at Houston Associate Director (Education) (1969-1970) and Professor of Biology and Pediatrics, M.D. Anderson Hospital and Tumor Institute (1959-1976) Dean and Professor of Medical Genetics, Graduate School o: Biomedical Sciences, Health Science Center (1970-1976) Professor of Pediatrics, Medical School, Health Science Center (1972-1976) Fox Chase Cancer Center 1976- Senior Member, Institu:.e for Cancer Research (1976- ) Director (1976-1982) and Scientific Director (1982-1983), Institute for Cancer Research President (1980-1982) University of Pennsylvania. School of Medicine 975 - , 1 ~ Adjunct Professor of Ped:at:ics and Hucan Cenetics 7 = EXHIBIT i ~ / -7 b:.111 , 226 L/ Ti w i i{ [ 011116

EXTRk1rLF..kL ACTIVITIES: National Institutes of Health Genetics Study Section - Member, (1954-1968). Chairman, (1972-197c' General Yedical Sciences Program Project Committee - Memoer (1966-:y72; US-Italy Cancer Program - Chairman, US Committee, (1979-1980) National Cancer Institute, Division of Resources, Centers, and CcWWunity Activities, Board of Scientific Counselors -!lember National Academy of Sciences - National Research Council _:`,4-63 1 81 Executive Committee, Division of Medical Sciences - Member (1974-1973) Board of Maternal, Child and Family Health Research - Chairman (1974-1977) Assembly of Life Sciences - Member (1975-1981) California Institute of Technology V.s:_.ng Ce_W...tee, Div.si.,.n c: Biology - Member --V- i::stitute for Cancer Researc., Phiiadeipiia, PA Scien,,...c Advisory Cc=__.:,ee - Member -7C-'4 Children's Hospital of Philadelphia Board of Scientific Consultants, Children's Cancer Research Center - Member, (1974-1975). Chairman (1975-1976) '.974-76 Cincinnati Children's Hospi:.a: Research Foundation Scientific Advisory Counci: -=75-78 UCLA Cancer Center Sc.en.,-fic Advisory Counci_ 1983- AWerican Journai of Human Genetics 1!ecber. Ed:tor_ai Board --7o-'7 !.n..uai F.eview of Genetics Menoer, Editorial Committee •770-79 Cancer Genetics and Cytogenetics 4ec~e:, Ecitor_ai Committee '_S7y-ES Cancer Research Associate Editor 1983- HONOP.S : B.S. with honor, 1944 Alpha Omega Alpha, 1946 Fe11ow, John Simon Guggenheim Memorial Foundation, 1953-54 President, American Society of Human Genetics, 1978 Electec MeWber, Association of American Physicians, 1978 Distinguished Aiumni Awarc California lnsitute of Technology, 979 Scientific A•Farc, American Cancer Society, Philadelphia Division, 198; CTR NN 0 1111 S4

BIBLIOGRAPHY: 1. Knudson, A.G. Mixed adrenal disease of infancy. J. Pediat. _:403-423, 1951. 2. Knudson, A.C. and Rothman, P.E. Hypervitaminosis A. A review vith a discussion of vitamin A. Am. J. Dis. Child. 85:316-334, 1953. 3. Knudson, A.G. Enzymatic conversion of alpha-formamicir.ob:_tar__ acic glutamic acid by rat liver. Nature 176:830-831, 1955. 4. Rattunde, H.F. and Knudson, A.G. A method for recovering :arge n_~~ers of platelets and leukocytes from normal human blood. J. La~. C:i::. Med. 54:484-486, 1959. 5. Knudson, A.G. and Natterson, J.M. Participation of parents hospital care of fatally ill children. Pediat. 26:482-49C, IS--:C. 6. Natter son, J..V.. a~c Knudson, A.C. Observations concern--:b __:.- _. ,.eatlI in fatallv ill c;^.ii..ren and their mothers. Psvc~oso=. ue-~^''-=.-55-4-Es. 1950 Reprinted in Death and Identity. Ed. by R. Fu::.o%, '"i:ey. York, 1965, pp. 225-239. 7. Knudson, A.G. Inborn errors of sphi^golipid met3bolisc. i.= _ Nutrition 9:55-62, 1961. 8. Knudson, A.G. and 'Kapian, K'.D. Genetics of the sphingcii _..:'ses i:: Cerebral Spningoii:)idoses. Ed. by Aronson, S.M. and N'o:k .,.*. Academic Press, \ew York, 1962, pp. 395-411. 9. };nudson A.G. Herec..,y and disease. (Ed.tor.al) An^ I ~~e _ ~; 345- 354, 1961. 10. Knudson, A.C. Cer.e:ics and Disease. l!cGraw-Hi1:, New pp, Spanish Ec:...,,. , 1970. ~=; 11. }:nucson, A.C. E'.°..-_ differences _.n c!:il--~nooc leuKe=ia aF ._ _a__.. stucv of antececent variabies. Cancer 1R:815-E18, 1955. 1?. }:nudsor, A.C. a:;.. A c.,,c-. C.D. '; eurob:astoca a::.a -:,-.e_-:=- -'. a •wi:,n mul.,.r:e ne,.rof.broxatosis. Ixplieat:ons ..,. _.._ origin of neuro'l-iastcsa. Cancer 15.1032-1C37, 1956. 13. Hallett, H'.Y., Kn'~;cson, A.C. and Massey, F.J. Absence .,. cet:_=en--a: effect of the car._-r state for the cyst:.. ..bres.., gene. A- ResD. Dis. 92:714-'24, 1965. 14. Knudson, A.G., Rayne, L., and Ha:iett. 'A.l'. On tne select:ve ac•:an;.a5e ci cystic fibros:s heterozygotes AWer J!!uc. Cenet . 1967. Reprinted in Natural Selection in Human Poauiations. .,. , C.7 Bajema. kiley, heK lorn, 1971, pp. 191-195. 15. }:nucsor A.C. Ce-:ge::.:.a: v.rai ...:ect..cn and ::uWan cisease. Naturalist. 100:162-154, 1966. A: _:_1" 620S CTR ! t!'! 011120

16. Knudsor., A.G., Brodetsky, A.11., and Baiuda, Y..A. Transie.^. of avian myeiobiastosis virus reproduction by aaethopter:.n aac deoxyuridine. J. Virology 1:1150-1157, 1967. 17. Knudson, A.G. and Owen, R.D. Molecular genetics and disease r-_:s:a.^.c°_. In Structural Checistrv and Molecular Biology (a voiume dedicatec - Linus Pauling by his students, colleagues, anc friends). c,z. zy A. ;ic:^. and N. Davidson, W.H. Freeman and Company, 1968, pp. 281-284. 18. Knudson, A.G. Inborn errors of metabolism. Ann. Rev. Ger.e:,. 3:1-24, 1969. 19.'F:nudson, A.G., DiFerrante, N., and Curtis, J.E. Effect of ie-j;co_:te transfusion in a child with type II mucopolysaccharidosis. P-cc Na.. Acad. Sci. USA 68:1738-1741, 1971. 20. Knudson, A.C. Mutation and cancer: statistical study of reti::o'-':as- toma. Proc. 'ra• Acad. Sci. USA 68:820-823, 1971. Repri..tec _.. Biochemicai Basis cf inherited Human Disease. Ed. by J.A. F.__---_r and R.T. Acton. MSS Ir.'ormation Corp., New York, 1973, pp. i5i-.-:,-. 21. Knudson, A.G. and Strong, L.C. Mutation and cancer: a mode: :.,: tumor of the kidney. J. Natl. Cancer Inst. 48:313-324, 1972. 22. Knudson, A.G. and Strong, L.C. Mutation and cancer: neurob:as:,c=s and pheochromocytoma. Amer. J. Hum. Genet. 24:514-532, 1972. 23. Knudson, A.G., Strong, L.C., and Anderson, D.E. Heredity and can:.er in man Prog. Med. Genet. 9:113-158, 1973. 24. Knudson, A.G. Muta•ion and human cancer. Adv. Cancer Res. 17:3:7-352, 1973. v 25. Knudson, A.G. LeuKecia - specific DNA and twins. Lance'. 2:1C32. :973. 26. Strong, L.C. and Knudson, A.G. Second cancers in retinobias:.c_a. Lancet 2:1086, 1973. 27. Knudson, A.G. Genetics of human cancer. Genetics 79 (Suppiezen:;: 305-316, 1975. 28. Knudson, A.G. Heredity and human cancer. Am. J. Pathol. 7- ---:4. 1974. Reprinted in Cancer Pathophysiology, Etiology. an ldanare=er.t Selected Readings. Ed. by L. C. Kruse, J. L. Reese, and L. K. har:,, The C. V. Mosby Company, 1979, pp. 57-62. 29. Knudson, A.C. The genetics of childhood cancer. Cancer 35:1022-1025, 1975. 30. Knudson, A.G. Toward the understanding and control of cancer. 1-r. Per- sons at High Risk ^` Cancer: An Aooroach to Cancer Etiology an~ Cor Ec. by J. .. trauWe.^. , Jr , Academic Press, 1975, 5:- ,,:_~~ 6209 CTR HN 0 111221

31. Knudson, A.C. Genetics and the etiology of childhood car.cer. Res. 10:513-517, 1976. 32. Knudson, A.G. and Meadows, A.T. Developmental genetics o: ~e ro~:as- toma. J. Natl. Cancer Inst. 57:675-682, 1976. 33. Knudson, A.G., Bethcote, H.W., and Brown, B.W. Mutation and c..iid::ccd cancer: a probabilistic model for the incidence of retinob:ast:=a. Proc. Nat. Acad. Sci. USA 72:5116-5120, 1975. 34. Meadows, A.T. and Knudson, A.G. Heterochroeia and neurobiast=a. _ Pediat. 88:168, 1975. 35. Knudson, A.C. Mutation and cancer in man. Cancer 39:1882-1885, 197:'. 36. Knudson, A.G., Meadows, A.T., Nichols, W.W., and Hi1:, R. C:-_-=:s=Za: deletion and retincb'.astoma. New Eng. J. Med. 295:1120-.:2"', .7--_ 37. Knudson, A.C. Genetics and etiology of huWan cancer. Ac:ances ___n Genetics b:1-66, 1y: . 38. Knudson, A.C. and Meadows, A.T. DevelopWental ge^etics c: in man. In Cell D;!ferentiation and Neoplasia, Proceedin6s ~. ___..-s ...c 30:,n Annual S,vmposium on rundamental Cancer Research. Ed. by C. .. za_-._ers, Raven Press, 1978, pp. 83-92. ' 39. Knudson, A.G. P,etir.cb:astcca: a prototypic hereditary necp:as_ ;_- Onc. 5:57-60, 1978. 40. Hethcote, H.W. and Knudson, A.C. A modei for the incidenze ..: cancers: applica•ic:: to retlnoblastoca. Proc. Natl. Acac. 75:2453-2457, 1978 41. Knudson, A.C. Herec_tary cancer. (Editcr_a:) J. A= uec Ass_= .. ='S 1979. 42. Knucson, A.G. Ou:• .cad of mutations and _ts burden cf cisease. J. HuW. Genet. 31:401-413, 1979. 43. Knudson, A.G. Persons at high risk of cancer. (Editorial; Ne* 4ed. 301:606-607, 1979. J. 44. Knudson, A.G. Genetics and the child cured of cancer. In Status cf the Curability of Childhood Cancers. Eds. J. van Eys and u. P. Su::i•:a-.. Raven Press, New 1orx, 1980, pp. 295-305. 45. Knudson, A.G. and Meadows, A.T. Regression of neurobiastoma genetic hypothesis. New Engl. J. Med. 302:1254-1256, 1980. 46. Knudson, A.G. Genetics and cancer. (Editorial) Am. J. V.ed. 69:i-3. 1980. 47. Knudson, A.G. Human cancer genes. In Genes, Chromosooes. and 14 eooiasia. Eds. F. E. Arrighi, P. N. Rao, and E. StubDief:eic, :.a~en Press, New York, 1981, pp. 453-462. V TR{ \N 0.F .ti. 1im• 2

48. Vooigavkar, S.H. an_ '-:^..dson, A.C. 1!utat..,.n ar.d cancer . a:..,c_- -_: ::u=a:: carcinogenes:s. JNatl. Cancer ins. 60:1037-1052, :y::. 4y. Knudson, A.C. Mode: hereditary cancers oi man. In Progress ... Acid Researc., ar.d ~oiecuiar Bioiogy. Vol. 28, E:. h.E. Co:^.;, .~cace=:c Press, ?~e•+~ York, 1983. 50. Knudson, .,.G. Hereditary Res. 45:1437-1443, 1985. cancer, oncogenes, and antioncogenes. rar.ce~ C T ~ t~~~ 0 ~.11~~.