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CTR HN 01109S

CUrZRICGi,I?f VI:A'c Education: 1940 B.Sc. 1942 X.Sc. 1946 Ph.D. *:anfred Leslie Karnovsky 10 Wymar. :cad, Ca-,:,S:idge, :!A 02133 December 14, 1918 Johannesburg. Scuth Africa (Vaturalized United States Citizen :4ay 7, 1956) University of :Jitaatersrand, Johar.nesburg, South Africa L'niversitv of l:i:watersrand, Johannesburg, Scu:h P.fr:=a University of Capetown Postdcctoral Training: Research Fellowships: 1947-48 1948-49 Research Fellow, Department of Biochemiscry, L'nive:sit~ r: ,isc.)nsin Research Fellow, Department of Biological Chenistry, :ar•:ar~ '.edical Academic Appoint:ients: 1941-42 Junior Lecturer, Organic Chemistry, University of :_t•:atersrzn~ 1944-47 Research Assistant, Department of Chemistt~•, 2:__ Caoeco,:n 19y9-50 Research Associate in Biological Chemistry, narvara `:z:::_: ;;hoo1 1950-52 Associate in B'_o'_ogical Chemistry, Harvard Nedica: 1952-58 Assistant Prof_ssor of Biological Chemistry. Harva:d `:ec'_:a1 Scnocl 1958-62 Associate Professor of Biological Chemistry, Harvar_ School 1959-60 Acting Head of the Dept. of Biological Che~is:r:, :ia--::-_ `:ecicai Scn 1962-65 Professor cf Biological Chemistry, riarvard `!ecica: 1962-69 Secretary c: the Faculty of Medicine, Harvard :~e::'-c<._ 1905-69 S,vndic of the Y.arvard Universitv Press 1965-Present 1969-73 Harold T. W"nite Professor of Biological Chemistrv,Ha.•:ar:: ::edical Sch: Chairman of Department of Biological Chemistry, ;?ar:a-_ "c--44-cal Schoc: 1975-76 Chairman of Department of Biological Chemistry, Har•:ari ':e~ical Schoo: Other Professional Positions: 1943-44 Awards and Honors: 1953 1955-58 1966 ve,South A: Chief CheWist,British 'linistry of Aircraft Produc:ior., "_-_ z~ Second Award of the Glvicerine Producers Association Lederle Medical Faculty Award _ Gold !fedal Award of the International Zeticulo-Endot::e'_:a_ Societv ~ EXHIBIT Y l~/ ~~r L C i R MA0 110 9 4

*San.'red L. .o: nc•: sR•: -2- Hajor Comunittee Assignments: 1956-64 National Research Council Subcor r,ittee on ;:omenc:a:_r e of Biological Chemistry 1955-61 Research Cummitcee, American Heart Association 1966-70 Medical Scientist Training CoTmittee, L'.S.?.:.5. 1971-72 General Medical Research Program - Projec: Co^-i:_ee, ..'_.G.`!.S: 1982- Secretary, American Academy of Arts and Sciences' Editoriai Boards 1954-59 Associate Editor, Journal of Histoch=mistrv and C::t=c^enistry 1961-69 Associate Editor, Journal of Biological Chemis::-;: 1960-69 Journal of Biological Che^istry 1964-67 Journal of Cell Biology 1971- PAA.BS Revista 1974- Infla^.ration 1978-80 Infection and Immunity Membership in Professional Societies Sigma Xi American Society of Biological Chemists The Histochemical Society American Chemical Society The Biophysical Society American Society for Cell Biology Society for Neuroscience Fellow, American Academy of Arts and Sciences CTR { \N 0 1109- 5

BLBLiCGRAPHY Manfred Leslie Karnovsky 1. Karnovsky, 1`:. L. and Raoson, ti': . S. : Periodic acid as a r_= _, in the analysis of the unsaponifiable fractions of natural J. Soc. Chem. Ind. , 65, 138, 1946. 2. Karnovsky, M. L. , Rapson, W. S. and Black, M. : The occ_: :=nce of a-glyceryl ethers in the unsaponiiiable fractions of .'ats. J. Soc. Chem. Ind. , 65, 425, 1946. 3. Karnovsky, M. L. , Rapson, W. S. and Black, M. : The reco•:e:v of unsaponifiable matter from marine oils by the Socie:y c: Public Analysts' method. J. Soc. Chern. Ind. , 66, 95, --. 4. Karnovsky, M. L. and Rapson, W. S. : App'.icatiorn cf ... _.._._ z method of "Seualene" determination to some mary.e c:'_s. J. Soc. Chem. L:d. , 66, 124, 1947. 5. Karnovsky, M. L. , Rapson, W. S. and van Rensbur g, N. : : e transesterificat:on and chromatographic treat^:ent of fis- oils as a means of concentrating vitamin A. J. Am. Oil Chem. Soc_ , 25, 36, 1948. 6. Karnovsky, h-1. L. , Rapson, W. S. , Schw'artz, I-1. M. , Blac:, '`.. and van Rensbur ¢, N. : The composition of the liver c::s c. :::e basking shark and the spiny shark. J. Soc. Chem. i.:d. , 67, 104, 1948. . 7. Karnovsky, M. ~.. , napson, W. S. and Schu'ar. ,,.. M. corr.pos:ti.... ..:er oils of the se•:en-g:.. s: ~..:. J. Soc. Cher:.. , 67, 144, 1948. 8. Karnovsky, M. L. , Rapson, W. S. , Lategan, Iti'. and Sc::•A•ar .,- AI. . The compositicn oi the liver oil of the souppiin shark. J. Soc. Chem. .rd. , 67, 193, 1948. 9. Karnovsky, M. L. and Johnson, M. J. ._T•-ilter-oaper c;:rraphy of penicillin br ct hs. Anal. Chem. , 2 1, 1125, 1949. 10. Gidez, L. 1. and Karnovsky, Ni. L. : Synthesis of a- or -:abelled glycerol. J. Am. Chem. Soc. , 74, 2413, 1952. 11. Teng, C. T. , Karnovsky M. L. , Landau, B. R. , r:ast.ngs, .. . ~ Nesbett, F. B. :-Metabolism of C14-labelled glycerol and ~.~:ate by liver in vi:ro. J. Biol. Che:ri. , 202, 705, 1953. 12. Gidez, L. 1. and Karnovsky, M. L. : The Metabolism o.` C' -~ , cerol in the intact rat. J. Biol. Chern. , 206, 229, 1954. 8 _ CTRHN 011096

Bibliography (2) Manfred Leslie F:arnovskv 13. Hauser, G. and Karnovsky, M. L. : Studies on the ;,_ glycolipide by Pseudomonas aeru9inosa. J. Bact. , 68, 14. Karnovsky, M. L. : A unified approach to the basic mecica: sc:ences at Harvard. J. Med. Ed. , 30, 15, 1955. 15. Karnovsky, M. L. and Deane, H. W. : Aldehyde forr-a tion lipide droplets of the adrenal cortex during fixation, as cemcnstratec chemically and histochemically. J. Histochern. and C;:;oc=e , 3, 85, 1955. • 16. Burgos, M. i-i. , Deane, H. W• and Karnovsky, :.i. L. :_•:s:oc emica: and chemical evidence for more than one alkaline p}:os.: c:-::zo- esterase. J. 'r'istochem. and Cytochem. , 3, 103, 1955. 17. Karnovsky, M. L. , Jeffrey, S. S. , Thompson, M. S. anc A chemical and histochernical study of the lipices o: ;.._ _:. cecum of the starfish, Asterias Forbesi. J. BioDhvs. anc _':~icchem. Cytol. , 1, 173, 1955. 18. Karnovsky, M. L. , Foster , J. H. , Gidez, L. I. , Hager:r.a=, ..,. D. , Robinson, C. V. , Solomon, A. K. and Villee, C. A. • Ccr rec_.cn factors for comnaring the activities of different C 1?-labe:'_e= compounds assayed in a flow, proportional counter. Anal. Chem. , 27, 852, 1955. 19. Long, E. R. ,?.aderson, R. J. , Rittenberg, D. , Karnovsk•:, ':. ~• and Henderson, ci. J, : The carbon metabolism of the t•_he-:.e bacillus: studies with isotopic carbon. Am. Rev. Tuber c. 20. Karnovsky, M. ._,. and Bru:r.m, A. r.. Studies on nat;.ra:.,.._.....ng a-glycerol eth ers. J. Biol. Chem. , 216, 689, 1955. 21. Karnovsky, M. ". , Stal:e'_in, H. , S~=er, - . _.on5, _. _.. an_ ~ Henderson, H. J. : Studies on the metabolism oi t.:ber cie and their fate after phagocytosis. International Congress on Peaceful Uses of Atomic Energy at Geneva, 10, 509, '•e:5. 22. Garvin, J. E. and Karnovskv, N:. L. , The titration of some ..osphatides a-nd related compounds in a non-aqueous meciiur:. J. Biol. Chem. , 221, 211, 1956. 23. Garvin, J. E. and Kar novsky, M. L. , The non-aoueous ...-~:.-.- o= lipids, vk•ith --a:...,:lar r_:er ence to r~hosphat:ces an.a re.z-.e_ -v.. v_. s. Biochemical Pr obiems of L 1Dids, G. Popiak (F..ditor ), pub. Butter.c•or ,,,, i.3ncoa, 1956, p. 14. l.rTR_ t li''F 011097 ~

Bibliography (3) Manfred Leslie Karnovskv 2=.. Gidez, L. I. cnd farnovskv. M. L. . The :,etabol.sm of Biochc:mical Probiems of Lipids, G. Pop;ak (Ed.), pib. B::e=: - - _ London, 1956. p. 301. 4. 25. " Stahelin, H., Suter, E. and Karnovsky, :1. L. : Studics ,,._ . .=.o p between phagocytes and tuberc:le bacilli. I. Observa:ier:s ,,.- . _::e -:ecabol•_ of guinea pig leucocytes and the influence of p'r.agocy:os=s.^ J. E::p. Med., 104, 121. 1956. 26. Stahelin. H., Karnovsky, M. L. and Suter. E.: III. The a--i^ - ~ ~ phagocytes upon C14-labelled tubercle bacilli. J. Ex~ ~:;'. ' 137. 1195, 27. Gidez, L.I. and Karnovsky, `1.L.: The metabolisW of g'.ycer:c_- glycerol. J. Biol. Chem., 223, 293, 1956. 28. Hauser, G. and Karnovsky, M.L.: Rha.:.nose and rhaanolicide <• ._-esis by Pseudomonas aerueinosa. J. Biol. Chem., 224. 91, :9`7. 29. of Stahelin, H., Karnovsky, M.L., Farnham, A.E. and Su:cr. _.. Sorr.e cetabolic effec:s in eui.n.ea pies associated with infect__-. :j berc le bacilli. J. Exp. Med., ]05, 265, 1957. 30. Karnovsky, M.L.. Hauser, G. and Elcryn, D.: The synthes_s a--' _e:abolis:rm of enantiomorphic ferrns of glycerol-1-C14. J. Biol. C::e-.. _ 881, 1957. 31. Rush, D., Kar ibian, D., Karnovsky, M.L. and Magasanik. F.. . ?a:=-.a;~s cf glycerol dissi^:ulation in two strains of Aerobacter aer.:e-:e,: er.z}:.atic and tracer studies. J. Biol. Chem., 226, 891, 1957. 32. 81Carnovsky, ?S.L.: A rearrangement of the curric,:lLn in __-e -_:__..ical years at Harvard. Harvard Alumni Bulletin, April. 1957. bNichols, G., Jr.,: A rearrangement of the curriculum in ;:-e -_eciinical years at Harvard. Harvard Med. Alu.-%ni Bull.. Spring, .. .. 33. Hajno, G. and Karnovsky, *:.L.: Studies on mveli::at_...n an_' T• Lipogenesis by nervou_ tissue in vitro. `eurol. fi. cc, 1950. 34. Moser, H. and Karr.ovsky, ?:.L.: Studies on the biosyn:r.es_s cere6roside galactose. Neurol. 8, Supplement 1, 81, 1958. 35. '"a jno, G. and Kar zovsky, "1. L. . A biochemical and : _.:d• of aryelinatiorn and derrvelination. I. Lipide biosynthesis __ - c by normal nervous tissue. J. Exp. Med., 107, 475, 1958. 36. ?'a jno, G. and Kar novsk.•, u. L. : A biochec.cal and - c. ___.:e: of myelination and demyelination. II. Lipogenesis : -_• ra; nerves following transection. J. Exp. Med., 108, 1917, _::-E. 37. Hauser, G. and Karnovsky, X.L.: Studies on the biosr:nt::esis ... ~- rharnnose. J. Biol. Chem., 233, 287, 1958. 3c. ""ajno, G. , Gasteiger , E. , La Gut:uta, M. and Karnovskv. u. :,. . Lipide biosynthesis in vitro by electrically sti^.ulated :at sc_a:ic nerves. J. ';eurocie stry, 3, 127, 1958. tr TR 1( l'f t..,e 1109Qs

Bibliography (4) Fanfred Lesl ie Karnovsk•: 39. Ashmore, J. , Karnovsky, M. L. and Hastin¢s, A. B. : "Intermediary Metabolism" in Radiation Biolom• a^c Walter D. Claus (Editor) Addison-Wesley Press, Reading, Massachubetts, 1958, p. 733. 40. Joel, C. D. , Karnovsky, M. L. , Ball, E. G. , Cooper, O:•a ::a: Lipide components of the succinate and reduced diphos~r ~: r:~ine nucleotide oxidase system. J. Biol. Chem. , 233, 41. Karnovsky, 1.LL. and Sbarra, A. J.: Metabolic changes :e•_cocytes during phagocytosis studied with C14 . Proceedings of t:;e se:ond International Conference on the Peaceiul Uses of A:orn:c Lae=~y, United Nations, N. Y. , 24, 82, 1959. 42. 43. Sbarra, A.J. and Karnovsky, M. L. : The biocherr:ca: phagocytosis. I. \1e:abolic changes during the particles by polymorphonuclear ieukocytes. J. Biol. Chern. , 234, 1355, 1959. Karnovsky, M. L. , Moser, H. and Majno, G. : "Lipid b:cs:n:^esis by peripheral and central nervous tissue as a function c: a2 e n Pro¢ress in tieurobiolo¢y, Vol. IV, "The Biology of Mvei_r- '. S. Korey ( Editor) Hoeber-Harper, N. Y. , 1959, p. :38. 44. Moser, H. and Karnovsky, 11M. L. : Studies on the biosv :=e_:s o: glycolipids and other lipids oi the brain. J. Biol. Che-:. , 234. 3, 1959. 45. Majno, C. ,:`,•a:csman, B.:, and Karnovskv, M. L. study of dip :.:,er.... poi ne ...:s .n t:e rabbi- an~ _:. _= ~- II• The effec: of diphtheria toxin on liptcsbiosynth es:s •zea pig nerve. ,,. Neuropath. and Exp. Neurol. , 1? 7, :. 46. Kar novsky ,\:. :... and Sbar r a, A. J• • l.ietabol:,_ chan_ °s accompanying the ingestion of par:iculate matter bv c..:s. J. Clinical Nutr ition, 8, 147, 1960. 47. Karnovsky, A:. L. and '.ti•olf:, D. :"Studies of stereospec:::c::y of lipases" in Bioche;r.istrv of Linids, C. Popjak ( Edicor; , Pergamon Press, London, 1900, p. 53. 48. Sbarra, A. J. and Karnovsky, 1`:. L. : The biochemical bas:s c. phagocytosis. ... lncorpora;.,,.. oi C1' -labeled b:.:'.= into lipid, protein and giycogen of leukocytes dur inc ^agc :cs:s• J. Biol. Chem. , 23-5, 2224, 1960. CTR HN 011099

Bibliography (5) Yanfred Leslie Karnovsky :9. Green, C. , Oncley, J. L. and Karnovsky, M. L. : Lipid composition of 1ipovroteins of normal human .plas^:a. J. Biol. Chem. , 235, 2884, 1960. 50. Karnovsky, M. L. and Majno. G.: "Lipid biosynthesis in vi:ro by cen:ral tracts and per ipheral nerves following transect:cn'' .~ Chemical Patholoev of Brain, Jordi Folch-Pi (Ed:tor), Pergamon Press, Loncon, 1961, p. 261. 51. Karnovsky, M. J. and Karnovsky, M. L. : Metabolic effects of lathyrogenic agents on cartilage in vivo and in vitro. J. Exp. Med. , 113, 381, 1961. 52. Eichberg, J. , Gilbertson, J. R. and Karnovsky, M. L. : Neutral plasmalogens analogous to the neutral triglycer ices. J. Biol. Chem. , 23c, : C15, 1961. 53. Karnovsky, M. L. and Wallach, D. F. H. : The metabolic basis of phagocytosis. III. incorporation of inorganic phosphate into various classes of phosphatides during phagocytosis. J. Biol. Chern. , 236, 1895, 1961. 54. Evans, W. H. and Karnovsky, M. L. : A possible mechanis:n for the stimulation of some metabolic functions during phagocytosis. J. Biol. Chern. , 236, PC30, 1961. 55. Kzrnovsky, M. L. : "Metabolic shifts in leucocytes during t:^.e YhaeQCyt1C evPnt" 'r A'olojlcal Actlvlty of the Le::roc`, te, C:ca Fo.i.-idation S:ucy Grc.:p No. 10, (Ed. G. E. 1V.%Volsten::olr-:e and M. O'Connor) (Ch.:r chill, London, 1901 ), p. 60. 56. Majno, G. and Karnovsky, M. L. : A biochemical and raor phcloz:, study of myelination and demyelination. III. Effect of an orCanc- phosphorus compound (Mipafox) on the biosynthesis of lipid by nervous tissue of rats and hens. J. Neurochem. , 8, 1, 1961. 57. Karnovsky, M. L. ,Maino, G. , Moser, W. H. and Joel, C. D. : "Defective metabolism of liaids in nervous tissue" in Neural -1-iar pe=, Inysiopathology, Vol. V. , R. Grenell (Editor), 'rloeber, N. Y. , 1962. 58. Karnovsky, M. L.: Metabolic basis of phagocytic activi', Physiol. Rev. , 42, 143,'.9t2 . 59. Evans, VJ. H . and Ka rmovsky, M. L. : The biochemical bas is ef pnagocytosis. I%'. Ser~e aspects of carbo~,ycirate metaboiis:a during phaQocytosis. Bicchernistry, 1, 159, 1962. :,= _°_"t --89 CTR HN 011100

Bibliography (6) 'lanfred Leslie Karnovsky 60. Karnovsky, M. L. and 1Vallsc::, D. _ H.'MetaOG:._ .__ -..=-_ mammalian cells to solid particles in "Role du sys:er.:e reticulo-endothelial dans 1'irnmunite antibacterienne e: a::: -craie"; ed. B.N. Halpern. Colloques Internationaux du Ce:.:re de la Recherche Scientifique No. 115, Gif-sur-Yvette, _. 147. 61. Karnovsky, M. L.: "Aspects comparatifs des modifica::~ns metaboliques au cours de la phagocytose." Comptes des seances de la Societe de Biologie. 156, 6, 1962. p. 62. Gilbertson, J. R. and Karnovsky, M. L. : Non-phos-~•:a:.--e fatty acyl esters of alkenyl and alkyl ethers of blti•ce:c:. J. Biol. Chem. 238, 893, 1963. 63. Oren, R. , Farnham, A. E. Saito, K. , Milofsk; F. Karnovsky, M. L. :Metabolic patterns in three types of phagocytizing cells. J. Cell. Biol. , 17, 487, 1963. 64. Eichberg, J. and Y.arnovsky, M. L. : The forma:ion of N-acetylneuraminic acid in ovine submaxillary gland. J. Biol. Chern. 238, 3827, 1963. 65. Cagan, R. H. and Karnovsky, M. L. : Enzymatic basis c. .-_ respiratory stimulation during phagocytosis. tiature, 196Y. 66. Karnovsky, M. L. :"Phagocytosis and Lipid \fetabol:s:-' :n Metabolism and P~~-=.iciooicai Siynificance of -_ -c R.1`;. C. Dau•scm and D.'`. Rhodes (Proc. =.cvancec _--• _--.-se, Cambridge, England, 19c3) Pub. John Wilev and Scns ~......-_• 1964, p. 501. 67. Karnovsky, M. L. and Gilbertson, J.R. Fatty subs:ar.,_= =c~:ai=ias ether linkages. Handbook of p'r.ysiology -Adipose ::-s::e, _• 177, 1°~~• 68. Karnovsky, M. L. , Shafer, A. W. , Cagan, R. H. , Grahar.:, r.. C. , Karnovsky, 1 ` : . . , . , Giass, E. A. and Saito, K. .``.E' -== _ =on and metabolism in phagocytic cells. Trans. N. Y. Acac. Sc:en:e, 28, 778, 1966. 69. Berger, R. R. and Karnovsky, M. L. : Biochemical basis cf ~:agocytosis. V. Effect of phagocytosis on cellular uptake of ex:racei:.::a= ,= S on the intracellular pool of L-a-glycerophosphate. : ed. =- ~-• = . 70. ~ichberg, J. and Karnovsky, M. L. ."Free" sialic ac:.. •-- submaxillary gland. Biochim. Biophys. Acta, 12-1, : , -- 9,. CTR HN 011101

Bibliography (7) Yan'-red Leslie Karnovsky 71. Reich, P. , Heane:-:an, E. and :;a_novslCy, ?.:. L. : `.ab- olism of glucose in resting and active sciatic nerve. J. Neurochern. 1-- 447, 1967. 72. Graham, R. C. , itarnovsky, M. J. , Shafer, A. W. , Glass, '. and Karnovsky, N:. L. : 1`letabolic and morpholoc:cal c:.ser va::cns on the effect of surface-active agents on leukocytes. J. Cell. Biol. 32, 629, 1967. 73. Jacob, H. S. and iriarnovsky, NL L. : Concomitan: alter_..,,_- of sodium flux and membrane phospholioid metabol:s::: in red blood cells: Studies in hereditary spherocytosis. J. Clin. Invest. 46, 173, 1967. 74. Joel, C. D. , Moser, ... W. , Majno, G. , and Karnovs:c,: ,'.'. ` Effects of bis-( r.:cnoisopropylamino)-fluoropnoscnine ct:c:_ ( Mipafox) and of starvation on the lipids in the ne rvous s~s :__- of the hen. J. Neurochem. 14, 479, 1967. 75. Reich, P. , Driver, J. K. , and Karnovsky, M. L. : Sleep: Effects on incorporation of inorganic phosphate brain fractions. Scietice, 157, 336, 1967. 76. Karnovsky, hT. L. : E-ner ~etics of transport. Protoplasma 63, 76, 1967. 77. Karnovsky, \:. :_. , Graham, R. , Karnovsky, ML J. , Sa:.,... Shafer, A. W. , and Class, E. . Phagocytosis and .._a:ec phenomena. Pr otcpp:asma 63, 88, 1967. 78. Jenkin, C. R. , Karnovsky, N1. L. and Rowley, D. : Pr ec =1..__ of an artificial an:i¢en and immunity to mouse t-yphoid. J. Immunolog}• 13, 361, 1967. 79. Jenkin, C. R. , and Karnovsky, M. L. : The effect of an... -.... the degradation of a polysaccharide by the reticulo-encc:^e::z~* system. J. Imm,.:r oiogy 13, 349, 1967. 80. Ellingboe, J. and Karnovsky, M. L. : Origin of gl}•ceroi et'-e:s: Biosynthesis from labeled acetate, stearic acid, steara1ce::~:ce and stearyl alcohol. J. Biol. Chern. 242, 5693, 1967. 81. Karnovsky, N:. L. : The metabolism of leukocytes. Seminars in Hematology, 156, 1968. C T R H"N 0 111022

Bibliography (8) ilanfred Leslie Karnovskv 82. Shohet, .,. B. , Nathan, D. G. and Karnc•: sk ". :.. . : _ -_es in the izcorporcrion of fatt•: acids inro red c. _ cells. ,,. Clin. invest. 47, 1096, 1968. 83. Baehner. R. L. and Karnovskv, M. L.. Deficie: _.,. reduced \icotinamide-Adanine Dinucleotide 0xidase in Chronic Granulo:aatous Disease. Science, 162, 1277, 1968. 84. Michell, R. H. , Pancake, S. J. ,Nosevorthv, J., a::z; Karnovsky, M. L.: Measurement of rates of phagcc.::zsis; The use of cellular monolayers. J. Cell Biol., 40, 216, 1969. 85. Halperir., M. L., Connors, H. P., Rel.:an, A. S. . a-_ Karnovsky, M. L.: Factors that control the e::ec: of pH or. glyco]ysis in leukocytes. J. Biol. C::e=. 244, 384, 1969. 86. Baehner, R. L. , Karnovsky, M. J. . and Kar novs::•: ,`:. I. . Degranulation of leukocytes in Chronic Granu1c-a_c,,:s Disease. J. Clin. Invest., 48, 187, 1969. 67. Karnevsk.:, M. L.: Annelida. Echiurida and Sipuncu:'_:a: Lipid components and metabolisr.;, in Che-ica1 7ce'_c-•:. Florkin, u. and Scheer, B. T., Ec:itors. Academic ?:=_ss. New York, Vol. 4, 205, 1969. 88. Eichberg, J. , Hauser, G. , and Karnovsky, `:. L. . Lipids cf ner•:ous tissue in Structure ~nd =_ Nervous '"issue, Bourne, G. H., Editor. New Yc:::. Vol. 3, 185, 1969. 89. l:ichell, R. H. , Karnovsky, `!. J. . and ]:arr.ovsky.`:. :.. The distributions of some granule-associated e.n.zy-es :.n guinea-pig polymorphonuclear leucocytes. Bioc::e=. :. 116, 207-216, 1970. 90. Baehner, R. L. , Gil;ran, N. . and Karnovsky, ':.L. : Respiration and glucose oxidation in human and guinea pig leukc tes. Co-parative studies. ,. C1_... -..:es_.. L9, 692, 1970. 91. Baehner, R. L. ,Nathan, D. G. • and Karnovsky, M. L. . Correction of metabolic deficiencies in the leuKoc•::es of patients with Chronic Granulorratous Disease. J. Clin. ln.vest. 49, 865, 1970. V TR , •N 0 11.Y .J. 3'

Bibliography (9) Ma nfred Leslie Karnovsky 92. ?Sichell, F.. H„ Hauth^rne, J. N., Coler.an, R., and Karnovsky, X. L.: Extracticn of Polvnhcsp~oinosit'_ces vith tieut:al and Acidi.fied Solvents. A cc-oar4sen e= guinea-pig brain and iiv2r, and reasure^:ents of ra: inositol compounds which are resistant to e::tract:on. Biochim. Biophys. Acta, 210, 86-91, 1970. 93. Karnovsky, ':. L. , S i^anons, S. , Noseworthy, J. , and Glass, E. A.: "`letabolic patterns that control the functions of leukocvtcs" in "For:natiorn and Destr::--:'_c- of Blood Ce'_1s". Eds., T. J. Greenwalt and G. A. a=:esc , Pub. J. B. Lippincott Co., pp. 207-221, 1970. 94, Karnovsk•;,`!. L., Simnons, S., Glass, E. A., S1a:e-. ... F,, and D'Arcy Hart, F. : "`ietabolism of *Sacrophages" :.. Mononuclear Phagoc}•tes. Ed. R. Van Furth, B1ack-we1: Scientific publications, Oxford and Edinburg. pp. 1970. 95. Karnovsk}•. ':. L. , Baehner, R. L. , Githens, S., S and Glass, E. A.: "Correlations of rnetabolisr.: an? in various phagocy:es" in "Irinunopatholog,: of Pub. Excerpta Medica, Ed. B. Forscher, pp. 121-132. :..:. 96, Nathan, C. F., Rosenberg, S. A. , Karnovsky, `:. :.. . z-:_ David, J. R.: Effects of MIF-rich supernatants on Proc. Fifth Leukocyte Culture Conference, Ed., J. °3:r:s. Academic Press, Inc., N. Y., pp. 629-638, 1970. 97. Pancake, S. J., and Karnovsky, *1. L. : The isolation a-.-` characterization of a mucopolysaccharide secreted . t_ :-e snail, Otella Lactea. J. Biol. Chem., 246, 253, 98. Nathan, C. .., F:ar novsity, ':. L. , and David. J. r.. Alterat:ons of .:ac:ovaaee functions by ...ediat.,rs 1)mphocytes. J. Exp. ued., 133. 1356, 1971. 99. Nathan, C. F.. Karnovsky, 2".. L., and David, J. ti. : "Alterations of macrophage function by *::F-ric'.^. supernatar.ts." I.y^unopatholog}• Sixth Ir.ternati.,::a? S}Wposiu:... Ed. P. A. :-liescher, Grune and Stratton (New York). 1971. 100. tioseworth,:, J., Korchak, H, and Karno^sky, M. L.: Phagocytosis and the sialic acid of the surface of polymorphonuclear leukocytes. J. Cell Physiol., 79, 91-96, 1972. 101. Reich, P., Geyer, S. J., and Karnovsky, ':. L.: Metabolisr.m of brain during sleep and vakefulness. J. t:eurocheW., 19, 487, 1972. CTR ilN 0 11104

Bibliography (10) Mar.fred Leslie Ksrnovsky 102. Karnovsky, X. L. , Si..mcns . S. , rarr.ovsky, :•:. J tioseworth;:. .;., and Glass, ... y.: "Co-:)arati'•e on the Metabolic basis of Bactericidal Act_ _,_.. Leukocytes" in "Phaeocvtic Mechanis.^..s in 'r.ea1::^, anc Disease", i.ds. R. C. ;;i1liaTs and H. Fudeaberg. Intercon:inental ".edical Book Corp., New :'ork ar.,; London, pp. 67-83, 1972. 103. Noseworthy, J. , Jr., and Karnovskv, `!. L.. Rcle .._ Peroxide in the Stimulation of the Hexose :!one:)::cs:-a:_ Shunt During Phagocytosis by Po1.-morpnonucleaz Leu'rcc;:_es. Enzyme 13: 110-131, 1972. 104. DePierre, J., and Karnovsky, M. L.: "Ectoenzymes. ______ Acid, and the Internalization of Cell ?:e-.c-ane Phagocytosis' in "In_°la.--ation" Eds. P. I. Lapow. Acadesiic Press. 105. Stubbs, M., Kuhner. A. V., Glass, E. A., Da:i . '... and Karnovsky, M. L.: Metabolic and Functional S___:_s on Activated Mouse Macrophages. J. Ex.pt1. `fed. ` 537, 1973. 106. DePierre. J. , and Karnovsky, M. L. : Plas.:a Mec:h:a-es Aa=naliar, Cells. A Review of Methods for Their Characterization and Isolation. J. Cell Eio:. ` 275-303, 1973. 107. Karnovsky, X. L. : "Chronic Granule:.atous Disease -:__ces of a Cellular and Molecular Puzzle." Svmposiu- c-. "The Bioche-is:rv of Disease.' Ed. _. Fa-^er. Federation Prcceedines 32• 1527-'_533. 10E. Reich, P. . Gever. S. J. , S:ei^bau-, L. ..1^.....,'s. ". and Karnovskv, ":. L.: Incorooration of P`:oso^at~- _-.•_ Rat Brain During Sleep and Wakefulness. ,,. Neu:ccne=. 20: 1195-1205, 1973. 109. Orange, .. P. ,`turphv, R. C., iCarnovsky, `:. L., a-:. Austen, K. F.: The Phy.sicoche^:ical Characteristics and Purification of Slow-Reacting Substance of Anaphylaxis. .,. 110: 760-769, 1973. 110. Si=nons, S. R., and Karnovskv, M. L.. Iodinatir_ A=:__ . of Various Leukocvtes and Their Bactericidal J. Exp. Med. 138: 44-63, 1973. CTR f f 1 • 0111015

Bibliography (11) !'.ar.-'r e3 Les lie Karnovsky 111. DePierre. and Karnovskv, `:. L. : Isolatic:: _: a nuclear fraction from guinea pig pol)^^orohonuciea: leukocytes F-ftcr cortrolled hypotonic ho-:ogenir.a::o.^.. Biochim. Biophys. Acta 320- 205-209, 1973. 112. •Githens, S., III, and Karnovsky, M. L.: Biochemical changes during groc..h and er.cystment of the cellu'_a_ slime rold PolvsDhondvlium oallidu.^... J. Cell Biol. 58, 522-535, 1973. 113. Githens, S., III, and Karnovsky, 2•1. L.: Phagocytosis by the cellular s1ime wold Polvsohondvlium oailic:- during growth and developnent. J. Cell Biol. 58, 536-548, 1973. 114. Cox, J. P. . and Kar novsk;•, `:. L. : The depress i.,.. .• phagocytosis by exoger.ous cyclic nucleotides, pres;a=:_-._'_rs. and theophylline. J. Cell Biol. 59, '+80-490. 19'3. 115. Brink, J. J.. and Karrovsky. *1. L.: Axonal flo:: of exogenous R: A in the rat optic nerve. J. Keur oc::e =. 21, 1003-1007 (1973). 116. DePierre, J. W., and Karnovsky, ':. L.: Ecto-enz}-e c. granulocvtes: 5'-nucleotidase. Science 183, 1096-1098, 1974. 117. Pappenheimer, J. R., Fencl, V., Karnovsky. M. L.. a-c: Koski, C.: "Peptides in cerebrospiral fluid ar.--' relation to sleep and activity" in "Brain Dys_'::n::'_=._ in Metabolic Disorders", edited by F. Plu^. Res. ?:..... Assoc. Nerv. "er... Dis. . Vol. 53. Raven Press. New York, 1974, pp. 201-2_0. 118. DePierre, J. W., and Karnovsky, `t. L. : Ecto-en:,:=es ~_ the guinea pig polyrnorphonuclear leukocyte. I. Evidence for an Ecto-A.`:Pase, -AT?ase, and phosphatase. J. Biol. Chea. 249, 7111-7120 (19%~.. 119. DePierre, J. F'. , and Karnovsky, `!. L. : Ecto-E.^.zynes of the guinea pig poly-morphonuclear leukec;:te. II. Properties and suitability as .:arkers for t::e plasma membrane. J. Biol. Chem. 2149, 7-'-1-7?'-9 CTR f i i i 01110G

Bibliography (12) "anfred Leslie Karnovsk;4 120. Drath, D. D. , and Karnovsky, M. L. : Bactericidal activity of .^..etal-mediated peroxide-ascor=ate s;•s:e-:. Infection & I mmunity 10, 1077-1053 (197=•). 121. Karnovsky, M. L.: "The biochemical basis of the _...._t__-s of polymorphonuclear leukocytes and cacrophages" _ Pro¢ress ir. I-^uncloev II, Vol. 4. eds. L. Bre.^.t a-:: J. Holborow, ;+ortn-Hoiland Publishing Co., amste::a-. 1974, pp. 83-93. 122. Karnovsky, ':. L.: "Biochemical aspects of the of polymorphonuclear and mononuclear ieu'r.ocvtes" The PhaQcc:•tic Cell Host Resistance, eds. _. ... and D. c. Davton, Raven Press, ::e:: York, 1?--.,;-r. __ --. 123. Briggs, R. T.. Karnovsky, u. L., and Karno:•skv, `:. Cytoche:aical demonstration of hydrogen peroxide i.n polymorphonuclear leukocvte phagosomes. J. Cell Biol. 64, 254-260 (1975). 124. Drath, D. B.. and Karnovsky, ".. L. : Superoxide producticn by phagocytic leukocytes. J. Exp. Med. 141, 257-262 (1975). 125. Karnovsky, `l. L., Lazdins, J., and Sicrmons. S. =.. "Iaetabolism of activated mononuclear pca;ocytes a: ->_:: and duri _ pha-ocvtosis" ir. ".ononuc'_ear Irr^~.:nit _°ection and ?athclcz•:. ed. R. Van :urtZ. Biackweli Scient_`i_ ?u*--..ca;_.,-.:. . Oxford, Edinburgh, and ".elbourne. 1975. pp. 23---: 126. Karnovsky, `:. L., Lazriins• J. . Drath. D.. and :'.a-:,e-. Biochemical characteristics of activated .:acropha:.es. Annals N. Y. Acad. Sci. 256, 266-274 (1975). 127. Karnovsky, ":. L. : Sur=ary: Role of ir._1a .mator;: ce: in the destruction of svnovial tissues. Annals N. Y. Acad. Sci. 256, 288 (1975). 128. Anchors, J. ", and Karnovsky. M. L.. Purification of cerebral glucose-6-phosphatase, An enzyme involved in sleep. J. Biol. CheW. 250, 6408-6416 (1975). =--- 014E- C TR- HN 0 11107'

Biblicgraphy (13) `:anfred Leslie Karnovsky 129. Pappenhe i^er, J. R. , tioski, C. , F encl, V. , Kar novsky .`:. ... . a:.c Krueger, J.: Extraction of sleep-pro^otinr Factor S from cerebrospinal fluid and from brains of sleep-deprived animals. J. Neurophysiol. 38, 1299-1311 (1975). 130. . Briggs, R. T., Drath, D. B., Karnovsky, M. L., and Karnovsky, ':. :, Localization of NADH oxidase on the surface of human poly-orp^c-:::c:ea- . leukocytes by a new cytochemical method. J. Cell Biol. 67, 1973. 131. Curnutte, J. T., Karnovsky, M. L., and Babior, B. M. : NADPH oxidation by granulocyte particles. The role of nonphysiological nature of the manganese requirement. 57, 1059-1067 (1976). *langanese-ce:endent superoxice a::c :he J. C:- :. =-:es:. 132. Stibbs, H. H. , Chernin, E. . Ward, S. and Karnovsky, ::. L. : `3z nes:_... emitted by snails alters sw•i:^: ing behaviour of Scnistcse-a l:ature 260, 702-703 (1976). 133. Drath, D. E., Harper, A. A., and Karnovsky, M. L.: Biochemica: characteristics of alveolar r.acrophages. In Luno Cells i.^. D:se=se A. Bouhuys, ed., Elsevier North-Holland Biomedical Press, 1976. _, 153-161. 134. 1arr.ovsky, M. L.: Enzy-atic components of the membranes of p az=:::ic leukocytes. In Mer.:brane Structure and Function of Hu^•ar. A symposium of the American Assoc. of Blood Banks, .,. Vyas, 2:., San Francisco, 1976, pp. 97-110. 135. Karnovsky, M. L.: VIII. Possible involvement of cerebral g. ccse-^- phosphatase in 2-deoxy-D-glucose phosphorylation: Reiaticns::i: c_ 2-deoxy-D-olucose p:osphorylation to local cerebral erergy In tieurosciences Res. Proc• Bull. 1~, N'e. 4; Y. `!. Horsy. e::. . Arts, 1976 pp. 505-506. 136. Karnovsky, M. L., Drath, D., and Lazdins, J.: Biochemical asve--:s c_ the function of the reticulo-endothelial system. Tn The ret'-c.:=- endothelial Svste^ in Health and Disease. S. Reichard, ::• R. 1=_:=a=, H. Friedman, eds., Plenum Press. Vol. 73A, 1976, pp. 121-129. 137. DePierre, J. W., and Karnovsky, M. L. : Assay of some ecto-er:z,.=e hydrolases on leukocvtes. In ?n %'i'ro uethods in Ce11-"e?ia_e: and Tumor Immunity. Barry R. Bloom and John R. David, :.ds., Academic Press, New York, 1976, pp. 353-358. 138. Karnovsky, *i. L., and Reich, P.: Biochemistry of Sleep. n A_-:•:a-_es in Neurochemistrv, Vol. 2, B. iv. Agranoff and "1. H. Aprisor•, ecs., Plenum Publishing, \ew York, 1977, pp. 213-275. 139. Briggs, R. T., Karnovsky, `i. L., and Karnovsky, *S. J.: Hydrogen :?-oxide production in Chroni; Granuloaatous Disease: A cytocheWica: reduced pyridine nucleotide oxidases. J. Clin. invest. 59 CTR_ {[S{ 0111.08

Bibliography (14) Y.ar.fred Leslie Karnovsky 140. Anchors, J. "!., Haggerty, D. F., and Karnovsky, ". L.. Cere~_r_: glucose-6-phosphatase and the movement cf 2-deoxy-D-glucose across cell membranes. J. Biol. Chem. 252, No. 20, 7035-70µ1 !::77). 141. Nixon, R. A., and Karnovsky, M. L.: Uptake and metabolism cf ~ intraventricularly administered piperidine ar.d its effects on s'_eeD and wakefulness in the rat. Brair. Research 134, 501-511 (197-,. 142. Stadecker, M. J., Calderon, J., Karnovskv, M. L., and l;r.ar.ue, E. Synthesis and release of thymidine by macrophages. J. Imrun:1. 119, 1738-1743 (1977). 143. Drath, D. B., Harper, A., Gharibian, J., Karnovskv, ?i. L., a:::: Huber, G. L.: The effect of tobacco smoke on the r_etabolis-n a-._ function of rat alveolar macrophages. J. Cell. Physiol. (1978). 144. Lazdins, J., Karnovsky, M. L.: Effect of phosphate esters, and nucleosides on 5'-nucleatidase of cultured mouse macr.:~hazes. J. Cell. Physiol. 96, 115-122 (1978). 145. Lazdins, J. K., Kuhner, A. L., David, J. R., and Karnovsky, `:. Alteration of some functional and metabolic characteristics c_ :es:dent mouse peritoneal macrophages by lymphocyte mediators. J. =xp. 143. 746-758 ;1978). 146. Karnovsky, M. L., and Lazdins, J. K.: Biochemical criter:a activated macrophages. J. Imrounol. 121, 809-813 ('_978). 147. Krueger, J. M., Papoenheimer, J. R., and Karnovsky, `:. L.: Sleep-premoting :ac:or S: Purification and properties. Proc. Natl. Acad. S_..LSA 75, 5235-5238 (1978). 146. Drath, D. B., Karnovsky, `1. L., and Huber, G. L.: Hydrox}•: -a_=- - forWation irn phagocyt4c cells of the rat. J. Applied Physie:. 46, 136-140 (1979). 149. Drath, D. B., Karnovsky, *1. L., and Huber, C. L.: T.obaccc Sr.c:<e: Effects on pulmonary host defense. Inflammation 3, No. 3, 2E:--o5 (1979). 150. Curnutte, J. T., Babior, B. `, and Karnovsky, !:. L.: Fluoride-mediated activation of the resoirato r: burst in hu.:.an ne::trocf:_s. A reversible process. J. Clin. Invest. 63, 637-647 (1979). V' TR [ i i i 0 11109

BiblioCraphy (15) Manfred Leslie Karnovskv 151. Badwey, J. A., Curnutte, ,,. T., and Kacnovsky, M. :,.. ;n e en.}me ef granulocytes that produces superoxide and peroxide. •\n c.-:perne':. Nev Eng. J. *!ed. ?nn, 1157-1150 (1979). 152. Badwey, J. A., and Karnovsky. M. L.: Production of superoxide ac:d hydrogen peroxide by an NADH-oxidase in guinea pig poly-crp^cr.u:'.ear leukocytes: lSedulation by nucleotides and divalent catic::s. . J. Biol. Cher. 25', 11530-11537 (1979). L53. Karnovsky, M. L.: A case of metabolic mimicry. New Eng'_. 301, No. 26, 14y2-1443 (1979). 154. Drath, D. B., Karnovsky, M. L., and Huber, C. L.: The effe_ts __ experimental exposure to tobacco smoke on the oxidati•:e -e:az;::s-: of alveolar macrcphages. J. Reticuloendothel. Soc. ?5 155. Drath, D. B., Davies, P., Karnovsky, M. L., and Huber, G. ~.• Tobacco smoke and t: e pul::oaary alveolar Tacrop^:ahe. Adv. Exp. Med. Biol., 121a, 555-568 (1980). 156. Karnovsky, M. L., F•adiaev, J., Briggs, R., Karnovsky, 'i. '.. a-t Lazdins, J.: Respiratory pathways of nacrophages - Cel:u:ar localization and relation to cidal activity.ZnMONCNCC:.7_AR '-:„_:7S FUNCTIONAL ASPECTS. Ralph van Furth, ed., ::zrtinus ..ij^ _. al Division, The Hague, Boston, London, 1980, pp. 1495-15::. 157. Zoccoli, M. A., and Karnovsky, '1. L.: Effect of two of anion transport on the hydrolysis of glucose-6-phosphate t_,. :a: liver microsomes. J. Biol. Chem. 255, No. 3, 1113-1119 (=9= ; 158. Smolen, J. E., and Karnovskv, M. L.: The effect of on guinea pig granulocyte membrane markers. J. Cellular .:s.__. 102, 71-80 (,9E0). 159. Smolen, J. E., ar.c Karnovsky, **.. L.: Effect of surface ._...___=:s on an ecto enz}ne: Cranulocyte 5'-nucleotidase. Infecticc: 5:=ur.ity 28, 475-485 (1980). 160. Badwey, J. A., and Karnovsky, *i. L.. Active oxv2en species a-._ ;he functions of phagoc~tic leukoc^tes. Ann. Rev. Riochem. ~ (1950). 161. SobetWan, R. ., and Karnovskv, M. L.: `:etabolism of ..._r.es _.n macrophages: E.`fect of functional state of the cells.V J. Exp. Med. 152, 2»1-246 (1980). 162. Karnovsky, *!. L., Burrows, B. L., and Zoccoli, M. A.: Cere'--ra: glucose- 6-phosphatase and the movement of 2-deoxyglucose during slc:: vave sleep, In CER.BRf,L `r"- .30:.:5" A: `'CCR~L NC':IO`' Passonneau ia_ . L.:st and Welsh, eds., rii1iaWs o,::ilkins. 1980,~pp. 359-366. _ _ _ _ C t O 4 V' i Y RHIi [ 011110

Bibliography (16) "anfred Les1iN ::arnovskv 163. DePierre, J. w., Lazdi^s, J and Karnovskv, X. .... The de:e--.-. _ion and localization of sialic a:.id in guinea pig granuloc;:tes. Biochemical Journal, L:+ndon, England, 192, (Part 2), 5=3-::u 164. Lazdins, J. K., Koech, D. K., and Karnovsky, M. L.: 0xida:i.... .,. glucose by mouse per'toneal macrophages: A comcarison of sus-,er:=_:=ns and monolayers. J. Ce_'.'_ular Physiol: 105, 191-196 (1980). 165. Badwey, J. A., Curn.utte, J. T., ^obinson. J. '!., Lazdizs, Briggs, R. T., Karnovsky, M. J., and Karnovsky, "(. L.: Comparative aspects oi oxidative metabolism of neutrcphils _-_- hu..^~an blood and guinea pig peritonea: 'Magnitude of the resc:-~:=-- burst, dependence upcn sti^ulatinz agents, and locaiizaticn c• :r.e oxidases. J. Cellu:ar Phvsiol. 10: '541-551 (19°0). 166. Karnovsky, M. J,......insor„ J. ", Briggs, R. T., and .:ar.._:s•- .... L.. Oxidative cytocheris.ry in phagocytosis: The ir.ter:ace be:=cer. structure and function. Histochemical Journal 13, 1-22 167. Badwey, J. A., Robinson, J. ", Karnovsky, `;. J., and E:arn..:s=., ".. L. Superoxide production by an unusual aldehvde oxiC3se-lT5 ~ui::ea ;__ granulocytes. Characterization and cvtocher:ical localiza::--r.. J. Bici. Chem. 256, 3479-348f, (19d1). 168. Karnovsky, M. L.: `!etchnikoff in Messina - A Century of stuc:es on phagocytosis. ~'ew Eng. J. Med. 304, 1178 (1981). 169. Soberman, R. J., anc Ksrnovskv, M. L.: Biochemical proper;ies :. activated macrophaees. in Lv::nhokines, Academic Press, '•. Vol. 3, 11-31 170. Adeniyi-Jones, S. K. and Karnovskv , M. L.. 0xidative deca-_c.' _a_icn of free and peptide-linked amino acids in cha2oc•:tizing e.:i-.es c' granulocytes. J. Clin. Invest. 63, 365-373 (1981). 171. Karnovsky, M. L.: Some reflections on biochemical approaches :: :ne phenomena of taste and olfaction. In Bio^he^istrv cr `=st' ': Olfaction. Cagan, R. H., and Kare, *S. R., Eds., Academic Press. 1-4 (1981). -•• 172. Karnovsky, M. L., Badwey, J. A., Karnovskv, M. J., and Tauber, A. How, where and why phagocyt:c 1eu,:oc:•tes produce sunerexide an= peroxide. In Membranes, Molecules. Toxins and Cells. Bloch, K., Bolis, L., and Tosteson, D. C., eds.,,.chn Vr ioh:, J -~ • -nc• , Boston, 1981, pp. 163-173. CTR HIN 0 11111

3ibliography (17) `Sanfred Leslie Karnovsky 173. 3advev, J. A., Curnu::e, .,. T, and Karnovskv, ".. L.: eis-Polyunsaturated fattv acids induce high levels of suoereyide production by human neutrophils. J. Biol. Chern. 255, 1'_6~G-:=;6-3 (1981). 174. Hoffer, A. P., and Karnovskv, M. L.: Studies on zonation i.. :=.e epididymis of the guinea pig. I. Ultrastructural and bioche-iZa: analysis of the zone rich in large lipid droplets (Zone I:). The Anatomical Record 201, 623-633 (1981). 175. . Karnovsky, M. L.: Biochemical factors associated with the s:ee:~ state. In Neural Basis of Behavior, A. L. Becl=an. Ed., Spectrum Publications, Inc., 1982, pp. 47-62. 176. Krueger, J. "1., Pa~penhei^er, J. R., and Karnovskv, ":. L.. --.E cemposition of sleep pro-noting factor isolated from hunar: _•_.._. J. Biol. Chem. 257, 1664-1669 (1982). 177. Zoccoli, `f. A., Hoopes, R., and Karnovskv, `t. L.: Iden:i._:a::_.I of a rat liver microsomal polypeptide involved in the transncr: of glucose-6-phosphate. J. Biol. Chem. 257, 3919-3924 (198=;. 178. Badwey, J. A., Curnutte,._J. T., Berde, C. B., and Karnovskv, `!. ~.. Cytochalasin E diminishes the lag phase in the release of superoxide by human neutrophils. Biochec. Biophys. Res. Cc=.. 106, 170-174 (1982). `. .'., 179. Badwey, J. A., Robinson, J. M., Adenivi-Jones, S. K., Karnovsky, and Karnovsky, M. L.: Superoxide-producing oxidases i.^n zuir.ea :z neutrophils: Collaberation in the respiratory burst,I^ Past and Future, Academic Press, Inc., 1982, Karnovsky, `:. ~.. - Bolis, L., Eds., pp. 193-213. 180. Karnovsky, `i. J., Robinson, J. M. , Briggs, R. T., and KarncvsK:: ,... .•• A cytochemical approach to the function of phagocytic leukocy:es, _ Phagocvtosis - Past and Future, academic Press, Inc., 1982, Karnovsky, M. L., and Bolis, L., Eds., pp. 215-238. 181. Karnovsky, M. L., Lazdins, J., Drath, D., Soberman, R., and Badc:ev, J.: Biochemical characteristics of macrophages in different functier.a: states, In PhaQocvtosis - Dast and Future, Academic Press, Inc., =?82, Karnovsky, M. L., and Bolis, L., Eds., pp. 419-428. 182. Zoccoli, li. A., and Karnovskv, u. L.: A polypeptide involved :., membrane transport of substrate for glucose-6-phosphohydrelase. In ?tembranes in Grovth and DeveloDment, Alan R. Liss, Inc., `ew '::rk• 1982, pp. 329-336. CTR HN 0 111 1':2

3ibliograahy (15) "a n'red Leslie K-novskv 183. Zoccoli, ?:. A. , Hoopes, R. r and Karnovsk.:,". L. . Rat liver microsomal glucose-6-P translocase: --- f f e c t of si.,_ ;a1 status on inhibition _-d :o'.~lizg by stilbene disul.'onic ac'_d de-i'a i:es. J. Biol. Chem. 257, 1_296-11300 (1982). 184. Krueger, J. `1., Pappenheimer, J. R., and Karnovsky, `:. L. Sleep-promoting effects of muramyl peptides. Proc. Nat. Acad. Sci. 79, 6102-6106 (1982). 185. Ka rnovsky, M. L., Anchors, J. 't., and Zoccoli, `".. A.: Glucose-6-phosphatase from Cerebrum, In Carbohvdrate `:etabolisn. Part E, A volume of Methods in - Academic Press, \ew York. ':o1. 90, 1982, pp. 396-402. 186. Robinson, J. `! , Kar.^.ovskv, *1. L., and Karnovsky, u. J.. Glycogen acciLmulation in pol;•^orphonuclear leukocti•tes and other intracellular alterations that occur during infla^^aticn. J. Cell Biol. 95, 933-942 (1982). 187. Karnovsky, *:. L.: Steps toward an understanding of C•.^.ron:.c Granulo,atous Disease. Editorial. N. Eng. J. Med. 308, 2'-~-=-: 188. Badwey, J. A., Rfl binson, J. `!., Lazdins, J. K., Briggs, R. ':., Karnovsky, M. J., and 1a rnovsky, M. L.: Comparative biochemical and cytocheWical studies on superoxide and peroxide in mouse r.acrophages. J. Cellular Physiol. 115, 208-216 (1983). 189. Badvey, J. A., Tauber, A. I. , and larnovskv, ':. L. : Properties of `:.D::-c.:tochrone b5 reduct3se irom hu^an Blood 62, 152-157 (19??). 190. l:arnovsky, **.. L. , Reich, P., Anchors, J. ':. , and Burrows, °. : Changes in brain glycozen during slow-wave sleep in the rat. J. Neurochem. 41, 1-9°-1501 (1983). 191. Karnovsky, `:. L., and Badwey, J. A.: Detsr^inants of the of active oxygen species by granulocytes and macrophages. V J. Clinical Chemistry and Clinical Biochemistry 21, 545-553 (19;-3). 192. Krueger, J. *, Walter J., Farnovsky, M. L., Chedid, L., Choav, Lefrancier, P., and Lederer, E.: Xuramyi peptides. Variation c: somnoger.ic activity with structure. J. Exp. Med. 159, 68-76 -- C CTR MIN 011113

Bibliography (19) "anfred Leslie Karnovsky 193. Karnovsky, M. L., Badc+ey, J. A., Curnutte, J. T., Robinson, Berde, C. B., and Karnovsky, H. J.: Some functional effects of physical changes in the membranes of white blood cells. In White Cell ltechanics: Basic Science and Clinical AsDects, "teiselman, H. J., Ed., Alan R. Liss, Inc., New York, 1984, op, 194. 2hai Sen and Karnovsky, !1. L.: Qualitative detection of mura^sic acid in normal macmalian tissues. Infection and Immunitv. 43, 937-941 (1984). 195. Badwey, J. A., Curnutte, J. T., Robinson, J. `i., Berde, C. B., Sarnovskv, M. J., and Karnovsky, !i. L.: Effects of free fatty acids on release of superoxide and on chan3e of shape by hu,.an neutrop:^.ils: Reversibility by albumin. J. Biol. Chem. 259, 7870-77 (1984). 196. Robinson, J. `I. , Badvev, J. A., Karnovsky, "i. L., and Karnovskv, `:. . Suoeroxide release by neutroohils: Svnereistic effects of a o.. ._c_ ester and a calcium ionophore. Biochem. Biophys. Res. Com:nun. 122, %3-:--'. 197. Karnovsky, `S. L., Baduey, J. A., Curnutte, J. T., Robinson, J. ".., Berde, C. B., and Karnovskv, M. J. 1984. The excitable mem5rane c: phagocytic leukocytes. In Information and EnerQv Transduction '_ Bioloeical Membranes, C.! Bolis, E.J.`t. Helmreich, H.Passow, EC I s., Alan R. Liss, Inc., New York, pp. 347-354. 198. Curnutte, J. T., Badwev, J. A., Robinson, J. M., Karnovskv, `:. .;.. and Karnovskv, `:.L.: Studies on the mechanism of superoxide re:e~s_ :rcW human neutrephils stimulated with arachidonate. J. Biol. C::e--. 259, 1t_851-11857 (1984). 199. Martin, S. A., Karnovsky, `i. L., Krueger, J. *1. , Pappenheimer, .".-. , and Biemann, K.: Peptidoglycans as promoters of slow-wave sleep. 1. Structure of the sleep-promoting factor isolated from human :::_r.e. .;. Biol. Chem. 259, 12652-12658 (1984). 200. Krueger, J. M., Karnovskv, Y.. L. ,?iartin, S. A., Pappenheimer, ,.:. :.. . ::alter, J., and Biemann, K.: Pepcidogiycans as promoters of sio;.-vave s:eep. II. Somnogenic and pyrogenic activities of some naturally occurring -.:ramvi peptides; Correlations with mass spectrometric structure determinat-on. J. Biol. Chem. 259, 12659-12662 (1984). 201. Badvey, J. A., Robinson, `, Karnovsky, `t. J., and Karnovskv, `:. 1.• Reduction and excitation of oxygen by phagocytic leukocytes: Biochemical and cvtochemical technioues. ln Handbook of Exoeriner.ca: :-znunoioev, 4th Edition, Blackvell Scientific Publications, Ltd., :.dinburg, Scc:-a'- 1984. in press. CTRI' HN 0 11114'

Bibliography (20) uanfred L. Karnovsky 202. Karnovskv, 'f. L., and Badwey, J. A.: The "respiratory burst" during phagocytosis: An Overview. In `F-TtIODS IN E`Z`."!OLCGy. In press. 1984. 203. Badwey, J. A., and Karnovskv, M. L.: NADH-oxidase from guinea =:z polymorphonuclear leukocytes. In `fETHODS IN E`JZY?lOLOGY. 204. In press. 1984. Karnovsky, M.L.: Trigger mechanisms for the release of tissue 05. active products of phagocycic cells. Svnposiuri on Pathogenesis of Bacterial Infection. George G. Jackson and H. Thomas, Eds., Springer-Verlag, In press. 1984. Karnovsky, `S. L.: Ectoenzvmes: Their modulation and similar::v ~e--.a7• . certain enzymes of intracellular membranes. In "Cellular Ectoenzvoes:' v. Zi::=erman and G. W. Kreutzberg, Eds. 206. Springer-Verlag, Fed. Rep. Germany. In press. Karnovskv, `1. L. : Comparative aspects of the production of exy ze- radicals by phagocytic cells, and aspects of other effector s::~,s:a-:es. In "Proceedings of the First World Conference on Infla=atic::." L. Bolis, Ed., Internat. J. Tissue Reactions. Bioscience Edi:t:-:: _.._. 8, 939 (1984). '01. i:arnovsKV, N. L. , and ?hilippeaux, ".. J. : Ectoenzvme action _.. __. _r.e nucleotides in macrooitaees and subseauent reactior:s. "r: of a Conference on Adenosine Deaminase in Disorders of ?urine cee::-.~s :2:2rc_:sm and in Im..^une Deficiency." G. L. Tritsch, Ed., Sciences. 1984. In press. ::ew York Acace=v =. C204 l.. M i Y'r t kN 01k.!. IE-3

BOOKS E^_TTcD Manfred l.eslie Yarnovskv Solomon, Arthur K., and i:rrnovsky, Manfred L., (Eds.) Noiecular Saecialization and Svr:r,etrv in Meabrane Eunction. Harv2rd Cniversity Press, Ca=bridge, :'--ssachusetts anc London, Tagland, 1978. Karnovsky, `fanfreci L., and Bolis, Liana (Editors). Phaeocvtosis - Past and y ure. Academic Press, \ew York,1952. CTR HN 011116