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CTR HN 01109S

CUrZRICGi,I?f VI:A'c Education: 1940 B.Sc. 1942 X.Sc. 1946 Ph.D. *:anfred Leslie Karnovsky 10 Wymar. :cad, Ca-,:,S:idge, :!A 02133 December 14, 1918 Johannesburg. Scuth Africa (Vaturalized United States Citizen :4ay 7, 1956) University of :Jitaatersrand, Johar.nesburg, South Africa L'niversitv of l:i:watersrand, Johannesburg, Scu:h P.fr:=a University of Capetown Postdcctoral Training: Research Fellowships: 1947-48 1948-49 Research Fellow, Department of Biochemiscry, L'nive:sit~ r: ,isc.)nsin Research Fellow, Department of Biological Chenistry, :ar•:ar~ '.edical Academic Appoint:ients: 1941-42 Junior Lecturer, Organic Chemistry, University of :_t•:atersrzn~ 1944-47 Research Assistant, Department of Chemistt~•, 2:__ Caoeco,:n 19y9-50 Research Associate in Biological Chemistry, narvara `:z:::_: ;;hoo1 1950-52 Associate in B'_o'_ogical Chemistry, Harvard Nedica: 1952-58 Assistant Prof_ssor of Biological Chemistry. Harva:d `:ec'_:a1 Scnocl 1958-62 Associate Professor of Biological Chemistry, Harvar_ School 1959-60 Acting Head of the Dept. of Biological Che~is:r:, :ia--::-_ `:ecicai Scn 1962-65 Professor cf Biological Chemistry, riarvard `!ecica: 1962-69 Secretary c: the Faculty of Medicine, Harvard :~e::'-c<._ 1905-69 S,vndic of the Y.arvard Universitv Press 1965-Present 1969-73 Harold T. W"nite Professor of Biological Chemistrv,Ha.•:ar:: ::edical Sch: Chairman of Department of Biological Chemistry, ;?ar:a-_ "c--44-cal Schoc: 1975-76 Chairman of Department of Biological Chemistry, Har•:ari ':e~ical Schoo: Other Professional Positions: 1943-44 Awards and Honors: 1953 1955-58 1966 ve,South A: Chief CheWist,British 'linistry of Aircraft Produc:ior., "_-_ z~ Second Award of the Glvicerine Producers Association Lederle Medical Faculty Award _ Gold !fedal Award of the International Zeticulo-Endot::e'_:a_ Societv ~ EXHIBIT Y l~/ ~~r L C i R MA0 110 9 4

*San.'red L. .o: nc•: sR•: -2- Hajor Comunittee Assignments: 1956-64 National Research Council Subcor r,ittee on ;:omenc:a:_r e of Biological Chemistry 1955-61 Research Cummitcee, American Heart Association 1966-70 Medical Scientist Training CoTmittee, L'.S.?.:.5. 1971-72 General Medical Research Program - Projec: Co^-i:_ee, ..'_.G.`!.S: 1982- Secretary, American Academy of Arts and Sciences' Editoriai Boards 1954-59 Associate Editor, Journal of Histoch=mistrv and C::t=c^enistry 1961-69 Associate Editor, Journal of Biological Chemis::-;: 1960-69 Journal of Biological Che^istry 1964-67 Journal of Cell Biology 1971- PAA.BS Revista 1974- Infla^.ration 1978-80 Infection and Immunity Membership in Professional Societies Sigma Xi American Society of Biological Chemists The Histochemical Society American Chemical Society The Biophysical Society American Society for Cell Biology Society for Neuroscience Fellow, American Academy of Arts and Sciences CTR { \N 0 1109- 5

BLBLiCGRAPHY Manfred Leslie Karnovsky 1. Karnovsky, 1`:. L. and Raoson, ti': . S. : Periodic acid as a r_= _, in the analysis of the unsaponifiable fractions of natural J. Soc. Chem. Ind. , 65, 138, 1946. 2. Karnovsky, M. L. , Rapson, W. S. and Black, M. : The occ_: :=nce of a-glyceryl ethers in the unsaponiiiable fractions of .'ats. J. Soc. Chem. Ind. , 65, 425, 1946. 3. Karnovsky, M. L. , Rapson, W. S. and Black, M. : The reco•:e:v of unsaponifiable matter from marine oils by the Socie:y c: Public Analysts' method. J. Soc. Chern. Ind. , 66, 95, --. 4. Karnovsky, M. L. and Rapson, W. S. : App'.icatiorn cf ... _.._._ z method of "Seualene" determination to some mary.e c:'_s. J. Soc. Chem. L:d. , 66, 124, 1947. 5. Karnovsky, M. L. , Rapson, W. S. and van Rensbur g, N. : : e transesterificat:on and chromatographic treat^:ent of fis- oils as a means of concentrating vitamin A. J. Am. Oil Chem. Soc_ , 25, 36, 1948. 6. Karnovsky, h-1. L. , Rapson, W. S. , Schw'artz, I-1. M. , Blac:, '`.. and van Rensbur ¢, N. : The composition of the liver c::s c. :::e basking shark and the spiny shark. J. Soc. Chem. i.:d. , 67, 104, 1948. . 7. Karnovsky, M. ~.. , napson, W. S. and Schu'ar. ,,.. M. corr.pos:ti.... ..:er oils of the se•:en-g:.. s: ~..:. J. Soc. Cher:.. , 67, 144, 1948. 8. Karnovsky, M. L. , Rapson, W. S. , Lategan, Iti'. and Sc::•A•ar .,- AI. . The compositicn oi the liver oil of the souppiin shark. J. Soc. Chem. .rd. , 67, 193, 1948. 9. Karnovsky, M. L. and Johnson, M. J. ._T•-ilter-oaper c;:rraphy of penicillin br ct hs. Anal. Chem. , 2 1, 1125, 1949. 10. Gidez, L. 1. and Karnovsky, Ni. L. : Synthesis of a- or -:abelled glycerol. J. Am. Chem. Soc. , 74, 2413, 1952. 11. Teng, C. T. , Karnovsky M. L. , Landau, B. R. , r:ast.ngs, .. . ~ Nesbett, F. B. :-Metabolism of C14-labelled glycerol and ~.~:ate by liver in vi:ro. J. Biol. Che:ri. , 202, 705, 1953. 12. Gidez, L. 1. and Karnovsky, M. L. : The Metabolism o.` C' -~ , cerol in the intact rat. J. Biol. Chern. , 206, 229, 1954. 8 _ CTRHN 011096

Bibliography (2) Manfred Leslie F:arnovskv 13. Hauser, G. and Karnovsky, M. L. : Studies on the ;,_ glycolipide by Pseudomonas aeru9inosa. J. Bact. , 68, 14. Karnovsky, M. L. : A unified approach to the basic mecica: sc:ences at Harvard. J. Med. Ed. , 30, 15, 1955. 15. Karnovsky, M. L. and Deane, H. W. : Aldehyde forr-a tion lipide droplets of the adrenal cortex during fixation, as cemcnstratec chemically and histochemically. J. Histochern. and C;:;oc=e , 3, 85, 1955. • 16. Burgos, M. i-i. , Deane, H. W• and Karnovsky, :.i. L. :_•:s:oc emica: and chemical evidence for more than one alkaline p}:os.: c:-::zo- esterase. J. 'r'istochem. and Cytochem. , 3, 103, 1955. 17. Karnovsky, M. L. , Jeffrey, S. S. , Thompson, M. S. anc A chemical and histochernical study of the lipices o: ;.._ _:. cecum of the starfish, Asterias Forbesi. J. BioDhvs. anc _':~icchem. Cytol. , 1, 173, 1955. 18. Karnovsky, M. L. , Foster , J. H. , Gidez, L. I. , Hager:r.a=, ..,. D. , Robinson, C. V. , Solomon, A. K. and Villee, C. A. • Ccr rec_.cn factors for comnaring the activities of different C 1?-labe:'_e= compounds assayed in a flow, proportional counter. Anal. Chem. , 27, 852, 1955. 19. Long, E. R. ,?.aderson, R. J. , Rittenberg, D. , Karnovsk•:, ':. ~• and Henderson, ci. J, : The carbon metabolism of the t•_he-:.e bacillus: studies with isotopic carbon. Am. Rev. Tuber c. 20. Karnovsky, M. ._,. and Bru:r.m, A. r.. Studies on nat;.ra:.,.._.....ng a-glycerol eth ers. J. Biol. Chem. , 216, 689, 1955. 21. Karnovsky, M. ". , Stal:e'_in, H. , S~=er, - . _.on5, _. _.. an_ ~ Henderson, H. J. : Studies on the metabolism oi t.:ber cie and their fate after phagocytosis. International Congress on Peaceful Uses of Atomic Energy at Geneva, 10, 509, '•e:5. 22. Garvin, J. E. and Karnovskv, N:. L. , The titration of some ..osphatides a-nd related compounds in a non-aqueous meciiur:. J. Biol. Chem. , 221, 211, 1956. 23. Garvin, J. E. and Kar novsky, M. L. , The non-aoueous ...-~:.-.- o= lipids, vk•ith --a:...,:lar r_:er ence to r~hosphat:ces an.a re.z-.e_ -v.. v_. s. Biochemical Pr obiems of L 1Dids, G. Popiak (F..ditor ), pub. Butter.c•or ,,,, i.3ncoa, 1956, p. 14. l.rTR_ t li''F 011097 ~

Bibliography (3) Manfred Leslie Karnovskv 2=.. Gidez, L. I. cnd farnovskv. M. L. . The :,etabol.sm of Biochc:mical Probiems of Lipids, G. Pop;ak (Ed.), pib. B::e=: - - _ London, 1956. p. 301. 4. 25. " Stahelin, H., Suter, E. and Karnovsky, :1. L. : Studics ,,._ . .=.o p between phagocytes and tuberc:le bacilli. I. Observa:ier:s ,,.- . _::e -:ecabol•_ of guinea pig leucocytes and the influence of p'r.agocy:os=s.^ J. E::p. Med., 104, 121. 1956. 26. Stahelin. H., Karnovsky, M. L. and Suter. E.: III. The a--i^ - ~ ~ phagocytes upon C14-labelled tubercle bacilli. J. Ex~ ~:;'. ' 137. 1195, 27. Gidez, L.I. and Karnovsky, `1.L.: The metabolisW of g'.ycer:c_- glycerol. J. Biol. Chem., 223, 293, 1956. 28. Hauser, G. and Karnovsky, M.L.: Rha.:.nose and rhaanolicide <• ._-esis by Pseudomonas aerueinosa. J. Biol. Chem., 224. 91, :9`7. 29. of Stahelin, H., Karnovsky, M.L., Farnham, A.E. and Su:cr. _.. Sorr.e cetabolic effec:s in eui.n.ea pies associated with infect__-. :j berc le bacilli. J. Exp. Med., ]05, 265, 1957. 30. Karnovsky, M.L.. Hauser, G. and Elcryn, D.: The synthes_s a--' _e:abolis:rm of enantiomorphic ferrns of glycerol-1-C14. J. Biol. C::e-.. _ 881, 1957. 31. Rush, D., Kar ibian, D., Karnovsky, M.L. and Magasanik. F.. . ?a:=-.a;~s cf glycerol dissi^:ulation in two strains of Aerobacter aer.:e-:e,: er.z}:.atic and tracer studies. J. Biol. Chem., 226, 891, 1957. 32. 81Carnovsky, ?S.L.: A rearrangement of the curric,:lLn in __-e -_:__..ical years at Harvard. Harvard Alumni Bulletin, April. 1957. bNichols, G., Jr.,: A rearrangement of the curriculum in ;:-e -_eciinical years at Harvard. Harvard Med. Alu.-%ni Bull.. Spring, .. .. 33. Hajno, G. and Karnovsky, *:.L.: Studies on mveli::at_...n an_' T• Lipogenesis by nervou_ tissue in vitro. `eurol. fi. cc, 1950. 34. Moser, H. and Karr.ovsky, ?:.L.: Studies on the biosyn:r.es_s cere6roside galactose. Neurol. 8, Supplement 1, 81, 1958. 35. '"a jno, G. and Kar zovsky, "1. L. . A biochemical and : _.:d• of aryelinatiorn and derrvelination. I. Lipide biosynthesis __ - c by normal nervous tissue. J. Exp. Med., 107, 475, 1958. 36. ?'a jno, G. and Kar novsk.•, u. L. : A biochec.cal and - c. ___.:e: of myelination and demyelination. II. Lipogenesis : -_• ra; nerves following transection. J. Exp. Med., 108, 1917, _::-E. 37. Hauser, G. and Karnovsky, X.L.: Studies on the biosr:nt::esis ... ~- rharnnose. J. Biol. Chem., 233, 287, 1958. 3c. ""ajno, G. , Gasteiger , E. , La Gut:uta, M. and Karnovskv. u. :,. . Lipide biosynthesis in vitro by electrically sti^.ulated :at sc_a:ic nerves. J. ';eurocie stry, 3, 127, 1958. tr TR 1( l'f t..,e 1109Qs

Bibliography (4) Fanfred Lesl ie Karnovsk•: 39. Ashmore, J. , Karnovsky, M. L. and Hastin¢s, A. B. : "Intermediary Metabolism" in Radiation Biolom• a^c Walter D. Claus (Editor) Addison-Wesley Press, Reading, Massachubetts, 1958, p. 733. 40. Joel, C. D. , Karnovsky, M. L. , Ball, E. G. , Cooper, O:•a ::a: Lipide components of the succinate and reduced diphos~r ~: r:~ine nucleotide oxidase system. J. Biol. Chem. , 233, 41. Karnovsky, 1.LL. and Sbarra, A. J.: Metabolic changes :e•_cocytes during phagocytosis studied with C14 . Proceedings of t:;e se:ond International Conference on the Peaceiul Uses of A:orn:c Lae=~y, United Nations, N. Y. , 24, 82, 1959. 42. 43. Sbarra, A.J. and Karnovsky, M. L. : The biocherr:ca: phagocytosis. I. \1e:abolic changes during the particles by polymorphonuclear ieukocytes. J. Biol. Chern. , 234, 1355, 1959. Karnovsky, M. L. , Moser, H. and Majno, G. : "Lipid b:cs:n:^esis by peripheral and central nervous tissue as a function c: a2 e n Pro¢ress in tieurobiolo¢y, Vol. IV, "The Biology of Mvei_r- '. S. Korey ( Editor) Hoeber-Harper, N. Y. , 1959, p. :38. 44. Moser, H. and Karnovsky, 11M. L. : Studies on the biosv :=e_:s o: glycolipids and other lipids oi the brain. J. Biol. Che-:. , 234. 3, 1959. 45. Majno, C. ,:`,•a:csman, B.:, and Karnovskv, M. L. study of dip :.:,er.... poi ne ...:s .n t:e rabbi- an~ _:. _= ~- II• The effec: of diphtheria toxin on liptcsbiosynth es:s •zea pig nerve. ,,. Neuropath. and Exp. Neurol. , 1? 7, :. 46. Kar novsky ,\:. :... and Sbar r a, A. J• • l.ietabol:,_ chan_ °s accompanying the ingestion of par:iculate matter bv c..:s. J. Clinical Nutr ition, 8, 147, 1960. 47. Karnovsky, A:. L. and '.ti•olf:, D. :"Studies of stereospec:::c::y of lipases" in Bioche;r.istrv of Linids, C. Popjak ( Edicor; , Pergamon Press, London, 1900, p. 53. 48. Sbarra, A. J. and Karnovsky, 1`:. L. : The biochemical bas:s c. phagocytosis. ... lncorpora;.,,.. oi C1' -labeled b:.:'.= into lipid, protein and giycogen of leukocytes dur inc ^agc :cs:s• J. Biol. Chem. , 23-5, 2224, 1960. CTR HN 011099

Bibliography (5) Yanfred Leslie Karnovsky :9. Green, C. , Oncley, J. L. and Karnovsky, M. L. : Lipid composition of 1ipovroteins of normal human .plas^:a. J. Biol. Chem. , 235, 2884, 1960. 50. Karnovsky, M. L. and Majno. G.: "Lipid biosynthesis in vi:ro by cen:ral tracts and per ipheral nerves following transect:cn'' .~ Chemical Patholoev of Brain, Jordi Folch-Pi (Ed:tor), Pergamon Press, Loncon, 1961, p. 261. 51. Karnovsky, M. J. and Karnovsky, M. L. : Metabolic effects of lathyrogenic agents on cartilage in vivo and in vitro. J. Exp. Med. , 113, 381, 1961. 52. Eichberg, J. , Gilbertson, J. R. and Karnovsky, M. L. : Neutral plasmalogens analogous to the neutral triglycer ices. J. Biol. Chem. , 23c, : C15, 1961. 53. Karnovsky, M. L. and Wallach, D. F. H. : The metabolic basis of phagocytosis. III. incorporation of inorganic phosphate into various classes of phosphatides during phagocytosis. J. Biol. Chern. , 236, 1895, 1961. 54. Evans, W. H. and Karnovsky, M. L. : A possible mechanis:n for the stimulation of some metabolic functions during phagocytosis. J. Biol. Chern. , 236, PC30, 1961. 55. Kzrnovsky, M. L. : "Metabolic shifts in leucocytes during t:^.e YhaeQCyt1C evPnt" 'r A'olojlcal Actlvlty of the Le::roc`, te, C:ca Fo.i.-idation S:ucy Grc.:p No. 10, (Ed. G. E. 1V.%Volsten::olr-:e and M. O'Connor) (Ch.:r chill, London, 1901 ), p. 60. 56. Majno, G. and Karnovsky, M. L. : A biochemical and raor phcloz:, study of myelination and demyelination. III. Effect of an orCanc- phosphorus compound (Mipafox) on the biosynthesis of lipid by nervous tissue of rats and hens. J. Neurochem. , 8, 1, 1961. 57. Karnovsky, M. L. ,Maino, G. , Moser, W. H. and Joel, C. D. : "Defective metabolism of liaids in nervous tissue" in Neural -1-iar pe=, Inysiopathology, Vol. V. , R. Grenell (Editor), 'rloeber, N. Y. , 1962. 58. Karnovsky, M. L.: Metabolic basis of phagocytic activi', Physiol. Rev. , 42, 143,'.9t2 . 59. Evans, VJ. H . and Ka rmovsky, M. L. : The biochemical bas is ef pnagocytosis. I%'. Ser~e aspects of carbo~,ycirate metaboiis:a during phaQocytosis. Bicchernistry, 1, 159, 1962. :,= _°_"t --89 CTR HN 011100

Bibliography (6) 'lanfred Leslie Karnovsky 60. Karnovsky, M. L. and 1Vallsc::, D. _ H.'MetaOG:._ .__ -..=-_ mammalian cells to solid particles in "Role du sys:er.:e reticulo-endothelial dans 1'irnmunite antibacterienne e: a::: -craie"; ed. B.N. Halpern. Colloques Internationaux du Ce:.:re de la Recherche Scientifique No. 115, Gif-sur-Yvette, _. 147. 61. Karnovsky, M. L.: "Aspects comparatifs des modifica::~ns metaboliques au cours de la phagocytose." Comptes des seances de la Societe de Biologie. 156, 6, 1962. p. 62. Gilbertson, J. R. and Karnovsky, M. L. : Non-phos-~•:a:.--e fatty acyl esters of alkenyl and alkyl ethers of blti•ce:c:. J. Biol. Chem. 238, 893, 1963. 63. Oren, R. , Farnham, A. E. Saito, K. , Milofsk; F. Karnovsky, M. L. :Metabolic patterns in three types of phagocytizing cells. J. Cell. Biol. , 17, 487, 1963. 64. Eichberg, J. and Y.arnovsky, M. L. : The forma:ion of N-acetylneuraminic acid in ovine submaxillary gland. J. Biol. Chern. 238, 3827, 1963. 65. Cagan, R. H. and Karnovsky, M. L. : Enzymatic basis c. .-_ respiratory stimulation during phagocytosis. tiature, 196Y. 66. Karnovsky, M. L. :"Phagocytosis and Lipid \fetabol:s:-' :n Metabolism and P~~-=.iciooicai Siynificance of -_ -c R.1`;. C. Dau•scm and D.'`. Rhodes (Proc. =.cvancec _--• _--.-se, Cambridge, England, 19c3) Pub. John Wilev and Scns ~......-_• 1964, p. 501. 67. Karnovsky, M. L. and Gilbertson, J.R. Fatty subs:ar.,_= =c~:ai=ias ether linkages. Handbook of p'r.ysiology -Adipose ::-s::e, _• 177, 1°~~• 68. Karnovsky, M. L. , Shafer, A. W. , Cagan, R. H. , Grahar.:, r.. C. , Karnovsky, 1 ` : . . , . , Giass, E. A. and Saito, K. .``.E' -== _ =on and metabolism in phagocytic cells. Trans. N. Y. Acac. Sc:en:e, 28, 778, 1966. 69. Berger, R. R. and Karnovsky, M. L. : Biochemical basis cf ~:agocytosis. V. Effect of phagocytosis on cellular uptake of ex:racei:.::a= ,= S on the intracellular pool of L-a-glycerophosphate. : ed. =- ~-• = . 70. ~ichberg, J. and Karnovsky, M. L. ."Free" sialic ac:.. •-- submaxillary gland. Biochim. Biophys. Acta, 12-1, : , -- 9,. CTR HN 011101

Bibliography (7) Yan'-red Leslie Karnovsky 71. Reich, P. , Heane:-:an, E. and :;a_novslCy, ?.:. L. : `.ab- olism of glucose in resting and active sciatic nerve. J. Neurochern. 1-- 447, 1967. 72. Graham, R. C. , itarnovsky, M. J. , Shafer, A. W. , Glass, '. and Karnovsky, N:. L. : 1`letabolic and morpholoc:cal c:.ser va::cns on the effect of surface-active agents on leukocytes. J. Cell. Biol. 32, 629, 1967. 73. Jacob, H. S. and iriarnovsky, NL L. : Concomitan: alter_..,,_- of sodium flux and membrane phospholioid metabol:s::: in red blood cells: Studies in hereditary spherocytosis. J. Clin. Invest. 46, 173, 1967. 74. Joel, C. D. , Moser, ... W. , Majno, G. , and Karnovs:c,: ,'.'. ` Effects of bis-( r.:cnoisopropylamino)-fluoropnoscnine ct:c:_ ( Mipafox) and of starvation on the lipids in the ne rvous s~s :__- of the hen. J. Neurochem. 14, 479, 1967. 75. Reich, P. , Driver, J. K. , and Karnovsky, M. L. : Sleep: Effects on incorporation of inorganic phosphate brain fractions. Scietice, 157, 336, 1967. 76. Karnovsky, hT. L. : E-ner ~etics of transport. Protoplasma 63, 76, 1967. 77. Karnovsky, \:. :_. , Graham, R. , Karnovsky, ML J. , Sa:.,... Shafer, A. W. , and Class, E. . Phagocytosis and .._a:ec phenomena. Pr otcpp:asma 63, 88, 1967. 78. Jenkin, C. R. , Karnovsky, N1. L. and Rowley, D. : Pr ec =1..__ of an artificial an:i¢en and immunity to mouse t-yphoid. J. Immunolog}• 13, 361, 1967. 79. Jenkin, C. R. , and Karnovsky, M. L. : The effect of an... -.... the degradation of a polysaccharide by the reticulo-encc:^e::z~* system. J. Imm,.:r oiogy 13, 349, 1967. 80. Ellingboe, J. and Karnovsky, M. L. : Origin of gl}•ceroi et'-e:s: Biosynthesis from labeled acetate, stearic acid, steara1ce::~:ce and stearyl alcohol. J. Biol. Chern. 242, 5693, 1967. 81. Karnovsky, N:. L. : The metabolism of leukocytes. Seminars in Hematology, 156, 1968. C T R H"N 0 111022