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C TR HN 010991

William U(llman) Gardner Born-Kinbrae, Minnesota (U.S.A.) Nov. 11, 1907 Parents James A. Gardner & Josephine Ullman Gardner Wife Katherine Homsley, July 15, 1934 Degrees. South Dakota State College. B.S. 1930 University of `:issouri `L4 1931 University of Missouri Ph.D. 1933 Yale University (honorary) MA 1943 [EXHIBIT 7~ South Dakota State College (honorary) D.Sc. 1960 University of Perugia (honorary) Dr. of Medicine & Surgery (_.aly) - 1969 Academic Avvointments National Research Counc4_ Fellow (Dept. Anatomy, Yale University) 193:-35 Research Assistant (instructor) " " 19:-5-37 Research Assistant (ass. professor) " " 1937-3E Research Associate (assoc. vrofessor) " " 153=-194: Associate Professor Professor and Chm. DeD•. Anat. E. K. Hunt Professor of Anatomy " " =°-5a- Adviso r: Functions and Cor.rittees Sec. and Treas. Ar. Assoc. Cancer Research 1942-45 President " " " " 1946-47 Vice president, Internat.ena: Union A;ainst Cancer (UICC) 1949-50 C;air-n~an, Co r,,L^ ittee on F e:-o•..,sn_ps (:::CC ) 196G-66 Chairman, Cocmnittee or. Feiiovsnips & Personnel Exchange (CICC) 1966-%: President-elect (UICC) 1966-%C E5:3~, EOEc; trTI`b i tN 010992

President UICC 19i0-74 President A,,. Association Anatomists, 1972-73 Member, Committee on Fellowship, National Research Counsel (NRC) 1945-J2 " " or. Naval Medical Research (NRC) 1962-1966 Member Board Scientific Advisors Jane Coffin Childs Memorial Fund 1953- Scientific Advisor Anna Fuller Fund 1953 Chairman. Teaching Ins:::ute, Anatomy and Anthropology, Assoc. A.nerican Med. Coi:ezes 1954-56 "lember. Na;ionai Adviso:: Cancer Counsel. liS?HS 1948-54 " Board of Scientific Counselors Nat. Cancer Inst. 1962-64 " Board of Governcrs, Eleanor Roosevelt Cancer Foundation 1962-66 Member. Cc;xaittee, Sci. ?ersonnel for Research. American Cancer Society 1962-68 Member. Coryittee on Anatomy, National Board of Medical Examiner (1958-62) Associate Edi:cr Cancer Research, 1931-1959 .;nator:ical Record 1940-1968 7x-erpta `Sedica - Cancer 1946 Anatomy Anthropology & Histology 1946- `le^:oershios A.erican Association of Anatomists. A-.. :,sso_-at.orn fo. Ca^:er Researcn. Society of Experimenta: Biology and Medicine. The Endocrine Society. Socie: ior the Study c: Develooment and Growth. .,ca~e- ef ,,:._ence. 6510 C~ 60 2, to+ i R t i t, 0109~t 3

Bibliography W. t:. Gardner 1. Turner, C. r., and Gardner, W. U. 1931. The relation of the -anterior pituitary hormones to the development and secretion of t:,e mammary gland. Mo. Agr. Exper. Sta. Res. Bull., 158. 2. Turner, C. W., Frank, A. H., Gardner, W. U., Schultz, A. B., and Gomez, E. T. 1932. The effect of theelin and theelol on the growth of the mammary gland. Anat. Rec., 53: 227-234. 3. Turner, C. f Gardner, W. L'., and Schultz, A. B. 1932. The relation c° the anterior ;,ituitary to lactation. Report of Aner. So:. of Animal ?-c_-~uction, Jan. Gardner, ~. ~., and Turner, ,,. ... 1933. Funct'_onal development c.' the matnrnary gland. Abst. 26th Annual Meeting of A.:.er. Dair}Soc. Ac,:o., Urbana, June. 5. Gardner, W. U., and Turner, C. W. 1933. The function, assay and prepara- tion of galactin, a lactation stimulating hormone of the anterior pit::itary and an investigation of the factors respon- sible for the cen;rol of normal lactation. Mo. Agr. Exper. Station, Res. Bull., 196. 6. Allen, E., Gardner, W. L'., and Diddle, A. h. 1934. Experiments with theelin and g.a:actin in monkevs. Anat. Rec., 58: 45. 7. Gardner, k'. U., Diddle, A. %:., Allen, E., and Strong, L. C. 1934. The effect e_` _:ee:-.n on the ma:marv rudiments of male mice differing ..n sasceptibilit.: te tumor developr,.ent. Anat. :.e_. , ,,. 457--- £. Gardner, w. U., i,ilen, .,=_:ong, L. C., and Didale, A. k. 1934. Thee::.d induced growt:; in mam:narv rudiments of male mice from ncrja: and i-ibred cancer strains. °rot. A.mer. . Assoc. Ana:, Ana:. Rec , 5b: .,3 iAbst.). 9. Allen, E, Gardner, W. C, and Diddle, A. w. 1935. Experiments with theelin and galactin on growth and function of the mammary glands c: _.._ -cnke}•. Endocrinology, 19: 305-313. 10. Gardner, t+. U., and Hii:, ... . 1935. Persistance of pituitary Frafts in the tes:_s o: the mouse. Proc. Soc. Expe:. Biol. an~ Med, 32: _3E_-_38~. Gardner, ... L' , Gomez, _. `, and Turner, C. ... 1935. =urtaer studies c: [:ie e::e:._s .,. tne es::':.e n__ a..., za=ac.o;,c_et__ ., ...._..-- upon tne ma-a:y glands ,,. tne rab„-_. :,: . . ?hys:c; , 112: 673-6°:. _=_J'3 6JC__ CTR HIN 010994

-2- .2. Gardner, W. L., and Strong, :.. C. 1935. The normal development of the mammary gland of virgin female mice of ten strains varyinz in suscept...__ity to spontaneous neoplasms. Am. J. Cancer, 25: 282-290. 13. Allen, E., Diddle, A. h., Strong, L. C., Burford, T. H., and Gardner, 1935. The oestrous cycles of mice during growth of spontane- ous mammary tumors and the effects of ovarian follicular and anterior pituitary hormones. Am. J. Cancer, 25: 291-300. 14. Gardner, W. U. 1935. The effect of ovarian hor:nones and ovarian graf:s upon the ma3mary glands of male mice. Endocrinology, 29: 656-667. 15. Gardner, W. U. 1935. Pelv4.c changes occurring in male mice receiving lar2e amounts o' :__ iculin benzoate. Proc. Soc. -7xDer. Biol. an_~ Med., 33: '_0--105. 16. Gardner, k. U., Smith, G. .. , and Strong, L. C. 1935. The sti:^ulation c: abnormal ra=arv growth by large amounts of estrogenic ior-;o::e. Proc. Soc. Ex?er. Biol. and Med., 33: 148-150. 17. Gardner, W. U. 1935. The effect of estrogenic hormones on the pelvis of the mouse. :.nat. Rec., 64: 54. (Abst.). 16. Gardner, k'. U., Smith, G. :, Allen, E., and Strong, L. C. 1936. Cancer of the maw.:.ar^: glands in male mice receiving estrogenic hormone. Arz... Path., 21: 265-272. 19. Gardner, h. U., Strong, L. Z, and Smith, G. M. 1936. An observation of primary tuWers of the pituitary, ovaries and mammary glands in one ro::se. n.,,. .,. .,a.,cer, 26: 341-346. 2: . Garcner, ;~. i . , Smith G. .. , :..:.,^ g, _.C , anc r.::er. , -. 19 3F,. llo...e: _ - ment of sa_z_-.a :n male mice receiv_ng estc genic hormc^.es. Arch. Pat:-.. , :'_: 50.:-50E. :, ... " , and Garcner , . . . 1936. Function of ~, _ zuitary grafts. Proc. S.,z. _x.er. i~iol. anc Ned., 3-:.76-79. -) , Gardner, u. U., Allen, E., anc Strong, L. C. 1936. Atypical uterine and vaginal cna.^.aes in mice receiving large amounts of estrogenic hor::one. A::a:. i:ec. , 6-.: _, (Abs: , . 23. :ii_ ,'r,. :, and Gardner, ... 1936. ?ne ^:aintenance o_` accesscrv crcaas by ovarian grafts castrate male cice. Anat. Rec., 6w: =1. iAbst. . Gardner, h. U. 1936. Sexua: dimorphis,^ of the pelvis of the mouse, t:ne effect .-f .._r.ncnes u;= the Delvis and upon the deve.e7!me::t c: scrota? .._:.._as. A.°,. ,;. Ana:, 59. -.57-..E3. G510:_' b()~ CTi~. i ii i 0.i 099:E_5

-3- 25. Strong, L. C., Smith, G. `:., and Gardner, W. U. 1936. Apparition anormale d'un epithelioma de 1' anus chez une sour:s du race pure (souche F). Bull. d. Cancer (France) 25: 1-9. 26. Gardner, l+. U., and Hill, R. T. 1936. Effect of progestin upon the mammary glands of the mouse. Proc. Soc. Exper. Biol. and Med., 34: 716-720. 27. Gardner, W. U., Smith, G. X., Strong, L. C., and Allen, E. 1936. Experimental production of malignant growths in mice by estrogenic chemicals. J.A.::.A., 107: 656-657. 28. Allen, E., Diddle, A. W., burford, T. H., and Gardner, W. U. 1936. Ovarian ho:-.,,::e threshold for experimental me.n.struatio.n 29. Gardner, k. U. in monkeys. A--,. J. Physiol., 117: 381-392. 1936. Interstitial cell hypertrophy in the testes cf -.ice receiving estrogenic hormones. Anat. Rec., 67: 49 (Abst.). 30. Allen, E., Smith, C. !i. , and Gardner, W. U. 1936. Accentua:ion of the growth effect of theelin on genital tissues by arrest of 67: 49 (Ab t ) i i : i hi A R i i 1. Allen, E. , . . m nat. ec., s tos s w t : co c ne. c Smith, G. :1. , an.. Gardner, '.~. U. 1937. Accentuation of the growth e`fect of theelin on genital tissues by arrest c` mitosis vit: colchicine. Amer. J. Anat., 61: 321-341. 32. Strong, L. C., Gardner, W. _, and Hill, i.. T. 193-. Production of estrogenic hormone by a transplantable ovarian carcinoma Endocrir.cicg::, 21: _'6c-272. .~. A i., Sr.._., ovaria:: 1937. horm.one anc ct::er estrogens. ology, 21 ^--- :3. 3». Gardner, ., . 'L:. 1937. ...__.:ence ot estrogenic hormones en abnorr.,a: g ro:... s. Sc-.e :undamental aspec.s .,. ,;:e cancer t)reoie-.. ucc. Yu--.. N.=. Assoc. Adv. Sc_ , . 67-75. 35. Gomez, E. ., Turner, C. ,.. Sardne*, 'v:. U., and R. T. 193,. uestrogen i: _reatment of .:pc~n.:se=:.,..._..". ...a1e ...___. S Bi d Pr i i c `: 36: 267-293 xver. . an e , oc. oc. o . 36. Gardner, r. U. 193'. v:)e::.cp^y of _nterst__ial cells in tne testes .. mice receiving estrogenic norr.,ones. Anat. uec., 6E: 339-3~^• . - - 1 A_ler, - , S-.__... G. `: , ar.= Gardner, ... 1.. _,3 . Accent,.a._cr. c. ;ne f " gro:..., e: ec_ c tnee:_.- on gen_ta: _.ssues c. to:;ixed mouse c•: arres: cf ..._tosis .._.., _.,.,...___^u. ..-•. = .=i na: . 6:: 66'_00 5J4C CTR HN 0 10996

-4- 38. Gardner, W. U., and Allen, E. 1937. Some effects of estrogens on the uterus of the mouse. Endocrinology, 21: 721-730. 39. Weinstein, L., Gardner, W. U., and Allen, E. 1937. Bacteriology of the uterus with special reference to estrogenic hormones and the problem of pycmetra. Proc. Soc. Exper. Biol. and Med., 37: 391-393. 40. Hamilton, J. B., and Gardner, W. U. 1937. Effects in female young born of pregnant rats injected with androgen. Proc. Soc. Exper. Biol. and Hed., 37; 570-572. 41. Allen, E., Smith, G. M., and Gardner, W. U. 1937. Growth of the ovaries and genital tract in response to ho:-mones as studied by tne colchicine :e_.,..'_oue. Anat. Rec., 67: 223 (Abst.). Gardner, l+. U., and Pfeiffer, C. A. 1938. Skeletal changes in nice receiving estrogens. Proc. Soc. Exper. Biol. and Med., 37: 678-679. 43. Gardner, l:. U., and van Wagenen, G. 1938. Experimental development of t^e marr.mary gland c: tbe monKey. Endocrinology, 22: 164-172. . Strong, L. C., Smith, G. K., and Gardner, W. U. 1938. Induction of tumors bv 3:4:5:6-dioenzcarbazole in male mice of the CBA strain, which deveicpes spontaneous hepatoma. Yale J. Biol. and `?ec.. 10: 335-346. 45. Gardner, n. U., and van Wa2enen, G. 1938. The influence of estrocens upor. the mammar,. _a:CS ef monkeys. Ana:. Rec, 70: 29 (Aos:.). 46. ...rschbau.:, A., Lits F. . .,_rong, L. C, and Garcner W. U. 1938. Studies on .^e _Wphocvtes e: nory,a: and ieuicemic mice. Anat. kec., :.,. 46 (Abst.)' . 47. Leblonc, C. ., and Gar,.ne:, ~. C. 1938. Compar_so.. ct _a zcne }: et des autres par':ec ce la surrenaie oe la scuris, a'_'aide du nitrate d'arte:::. Compt. rend. Soc. ce Bio:., ;27: 775. 48. Gardner, 4:. „, Allen, E., ..~_.. , G. '1 , anc Strong, L. C. 1938. Car.inoma of tne cer•.:x _. Wice receivinb estrogens. J.A.':.A., '_182-1183. 49. Gardner, W. U., and Pfeiffe:, C. A. 1938. Inhibition of estrogenic effects on the skeie:or. oy testosterone iniections. Proc. Soc. ixper. Bio1. and `:e-~., 3c: 599-602. La~:e::cc, _'. ... , and Garc.._: ;ransrissibie 1euee_:.:a 'ie 'A' s:ra:.- c: W.ce. An. Cance:, _. :_ -__. ~e:_,,.. , C. P, and Gardne:, ~. ~. .938. Distr.cut_on c: ..tam :.. C_.. the adrenal g;ar.d of tne mouse witn reference tc tne nature of the X zone. Anat. Rec., 72: 1-17-1:9. 6=:d4' 639•_ CTR MN 0109-97"

-5- 5_. P: eiffer , C. A., and Gardner, ,::. U. 1938. Skeletal c::anEes and blood serum calciu.: level in pigeons receiving estrogens. Endocrinology, 23: 435-491. 53. Strong, L. C., Hill, R. .,?feiffer, C. A., and Gardner, ::. .,. 1938. Genetic and endocrine studies on a transplantable carcir.o-aa of the ovary. Genetics, 23: 585-595. 54. Pfeiffer, C. A., and Gardner, W. U. 1938. Effects of estrogen and estrogern plus 'k:: c~rtes and gonaducts of adult male pigeons. Anat. Rec., 72: 59 (Abst.). 55. S^ith, P. F:. , and Gardner, ,-~. l:. 1939. A note on the lack of carc_..cceni_ action of some cardiac glucosides and saponins. Yale Biol. and , :1: 18i-18o. 56. Gardner, i:. U. 1939. Es,rcAens in carcinogenesis. Arch. ?at::., 138-170. 57. A:len, E., Hisau, F. L., a::-,f Gardner, V. U. 1939. The endocrine : un;.tions of the ovaries. Chap. VIII (edited b%• Danforth Baltimore. i an n Sex and internal Secretions d Doisv) hillia^s and Wilkins, jS. Gardner, :.'. L'. , and Pfei.'fer, , C. A. 1939. Sex hor:nones and bone c:ianges in mice. -.r.ac. Rec., 73: 21 (Abst.). 59. Landauer, t+'. , Pfeiffer, Z. .1,., Gardner, W. C. , and Man, E. L. 1939 Hypercalcif_=a:ion, - calce-:ia and - lipemia in chickens folloving ac-.:n'_s:ratior, o: estrogo::s. Proc. Soc. Lxper. Biol. and Xe::., _. 80-E: . 60. van Heuversvvn, J Fo__ev,_. J, and Gardner, ... ... 1939. `+.a- ar cr.•~... in male ...__: -_ce:v_- ancro:ens. estroeens and desoxvicertice- sterone. .r_c. Soc. Exper. Bio:. and :led., 41• 389-39~. 61. van Heuvers: , . , Co-__..s. an,. Garcne , ... :.. _~39. :ne proges__:_ne-_iM1e ac.iv_, of ceso:c} .,.:_costerone. Proc. Soc. _x.er. Bicl. and Med., 1 552-55ti. 62. Gardner, r.. L' and :,lien, --. Uter_ne reac._ons ,., iong-con..-nue;: i;c.....,.,- injections. :..,_. ..,_rd _..ternat.,,na'_ Cancer Conzress, p. 158 (A. ns;.:. 63. }:irschbaur.,, A., Pfeiffer. ,... P.. , van Heuvers4}•n, `: ., and Gardner, l:. ,,. 1939. Stuc_es _.n gonad-nvpopnysea: relat.onst:•, and Z.__ osceous c:anze~ _.n t:e EnFlisn sparro•.:, Passer co~est__ ; . Ana;. :.e- ?c~. i~. Garener, r. U., and n:_er. ... _935. and anc vaginal iesions in ,.,,ce receiv:ng estrogens an:- es.ro:;e:.s and androgens si-.uitaneous'..:. 'ia:e .,. Eioi. an:: `:ec., :2 : =--- CTRMN 010998

-6- )5. Gardner, W. U., Strong, L. C., and Smith, G. M. 1939. The ma.-Wnary glands of mature female mice of strains va:^:ing in suscepti- bility to spontaneous tumor development. Am. J. Cancer, 37: 510-517. 66. kentworth, J. H., Smith, P. K., and Gardner, 4;. U. 1940. The composition of bones of mice receiving estrogens and androgens. ' Endocrinology, 26: 61-67. 67. Gardner, k. U., Kirschbaum, A. and Strong, L. C. 1940. Lymphoid tumors in mice receiving estrogens. Arch. Path., 29: 1-7. 68. Gardner, W. U. 1940. Modifications of bones of animals receiving sex horaones. Ana:. Rec., 76: 22-23 (Abst.). 69. Gardner, h. U., and van Heuverss.ryn, J. 1940. I.n.hibition of pelvic ;hanges occuring during pregnancy in mice by testosterone propicna:e. Endocrinology, 26: 833-836. 70. Kirschbaum, A., Gardner, W. U., Nahigian, R., and Strong, L. C. 19=+0. Differentiaticn between sarcomatous and leukemic lvmohocvtes in mice. Yale J. Biol. and Med., 12: 473-482. 71. Pfeiffer, C. A., Emmel, ':. `: , and Gardner, k. U. 1940. Renal hypertropn_v in mice receiving estrogens and androgens. Yale J. Biol. and Med., :2: 493-501. 72. Gardner, U., and Strong, L. C. 1940. Strain-limited development of tumors of tne pituitary gland in mice receiving estrogens. Yale J. Biol. and Med., 12: 543-548. 73. Hooker, C. l+'., Gardner, ::. _, and Pfeiffer, C. A. 1940. Testicular tumors in Wice receiving estrogens. ... Amer. Ned. Assoc., 11~: 443-•.'+J. 74. Gardner, L,'. U. 1940. ::-:e oreaKing strength of femurs of mice receiving estrogens. Tercc. Soc. Exper. Biol. and Med., 45: 230-232. 735. ... r sCnbau:;, A. , Strong, `.. , and Gardner, i:. L'. 19- :.. L^.: luence cf methvlcholan:hrene on age incidence of leukemia in several strains of nice. Proc. Soc. Exper. Biol. and Med., 45: 387-389. 76. Pfeiffer, C. A., KirscabauW, A., and Gardner, W. U. 1940. Relation of estrogen to ossification and the levels c: seruW calci~= and lipoid in the English sparrow, Passer domesticus. Yale J. Bio:. and Med., 13: 279-284. Gardne:, .,. ., , aza Dea, .,. 194 0. In:^._b,t-o^, o_ ha:r crowt,. .., do,s receiving est:cgens. Yale .,. Biol. and *led., 13: 7E. Gar,.ner, ... U. 1940. Gro._.. ,,: the naWmary glands in hypophvsectom_zec nice. Pro:. So:.. Exper. Bic1. and ":ed., 45: 835-837. _:- :0 C~ 6C°= CTR HN 0 10999

79. Gardner, ... U. 1941. in :ib_.ion of ma^ur:ary growth by larce amounts c: estrogen. ........,.. inology , 28: 53-61. 80. Gardner, l+. U., and Chamberlin, T. L. 1941. Local action of estrone on mammary giands of mice. Yale J. Biol. and Med., 13: 81. Landauer, W., Pfeiffer, C. A., Gardner, W. U., and Shaw, J. C. 1941. Blood serum and skeletal changes in two breeds of ducks receiving estrogens. Endocrinology, 28: 456-464. 62. Gardner, W. U., Allen, E., and Smith, G. M. 1941. Hyperplasia and hyper- trophy of the mucosa of larger biliary ducts in mice receiv- ing estrogens. ?roc. Soc. Exper. Biol. and !:ed., 46: 5_'_-513. 83. Blaisdell, J. S., Gardner, :.. „, and Strong, L. C. 1941. Adrenal glands of mice fro= strains with different susceptibilitie=_ to ca^mary ca: c_..cma. Cancer nesearc :, .. '-e?-C189. 84. Chamberlin, 65. Gardner, :'. T. L., Gardner, '-:. U., and Allen, E. 1941. Local responses of the 'sexua: skin' and mammary glands of monkeys to cutaneons applications of estrogen. Endocrinology, 28: 753-757. U. 1941. T::e =: f ect of estrogen on the incidence of mammary and pituitary :,jmois in hybrid mice. Cancer Research 1: 345-356. 66. Allen, E, and Gardner, "... 1". 1941. Cancer of the cervix of the uterus in hybrid m_:e following long-continued ad;:inistration c: estrogen. .., ncer Research 1: 359-366. 8'. Gar::ner, ,::. U. 1941. r°fects of ac'rena'_ tumors of ovariecteM- _zed ..,ice. ~a..cer Researci 1: 633-63=. n; ?op^. sec. ..._zea 68. Gazdnez, ~. 194_. ~ ----.ents OL ^aC...ar\' gr„ .•. _.n maie mice. :..a:. Rec, 79. 23-2.. (J,bst ) 89. Garcner. and e. .:. 17=+?. '.lam_^ar. _-ow_.. _.. :pop:ysec.oc.:zec ale __z =____.ing estrogen ane~pro:ac._... Proc. 3oc Exper. B:. _ a..c `;ed., 46: 59G-5K. 90. Gardner, w. U., and A1'_e-., i. 1942. Effects o2 nvpophysectomv at mid- pregnanc,: _.. t:Ie mouse. Ana:. Ee_., ?3• , _-97. 91. Gardner, i:. 'C. 1942 . ?e:s:s:ence anc gro:.tn o: spontaneous mam:nar tu:-ors and hyper;las:ic nodules irn nvpoonvsectomized mice. Research =. .:-6-488. C,ardne:, ... a.^, 4a •-,ar cro:._.. _.. :po;h"sec_c-.._ _1 L,ale •...ce. :..a_. Kez . G_. __ ~nJS:.~. 93. ;,ardnez, ... .,. 1942. ".a--ar tumors in r.,_ce rece:ving sex norm::nes. Cancer kesearc.. _. 72_r (A-_s:.). tr Ti'., t iN 011000