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CTR HN 010961

CURRICULU:1 VITAE JOHN E. CRAIGHEAD, M.D. Home Address: 9 Iranistan Road, Burlington, Vermont 05401 Personal Historv: Born - August 14, 1930, Pittsburgh, Pennsylva:.:a Married - Dorothy Ellen Ford, July 29, 1957 Education: 1952 - B.S., University of Utah 1956 - M.D., Univetsity of Utah Anoointments: 1955 Los Alamos Scientific Laboratory, Los Alamos, New Mex:co ( summer ) 1956-57 Intern, Ward Medical Service, Barnes Hospital, St. Lo::is, Missouri 1957-58 Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Maryland 1958-60 Middle American Research Unit, National Institutes of Health, Balboa Heights, Canal Zone 1960-61 Junior Assistant Resident in Pathology, Hospital, Boston,.-Massachusetts_ _ Peter Bent Bric:a:n 1961-62 Senior Assistant Resident in Pathology, Hospital, Boston, Xassac :usetts Peter-Bent Br_c::am 1962-63 Chief Resident in Pathology, Peter Bent Brigham Hosp:tal, Boston, Massachusetts 1961-63 Teaching Fellow in Pathology, Harvard Medical School, Boston, Massachusetts 1963-66 Associate in Patholocy, University full time, Medical School, Boston, Massachusetts Harvard 1963-68 Associate in Patholccv, Peter Bent Brigham Hospital, Boston, Massachusetts 1966-68 Assistant Professor of Pat';olccy, HarvarC Medical 5:.hoo_, Boston, ?;assac::::setts = EXHIBIT ~ = --=---- 3 , s=' L CTR HN 010962"

1968-69 Associate Professor of Pathology, University of Ver-.znz~ College of Medicine, Burlington, Vermont 1969- Professor of Pathology, University of Vermont Collece of Medicine, Burlington, Vermont 1970- Attending Physician, Medical Center Hospital of Vermont, Burlington, Vermont 1974- Professor and Chairman, Department of Pathology and Director of Laboratories, Medical Center Hospital of Vermont and University of Vermont College of Medicine, Burlington, Vermont Societies: American Association for the Advancement of Science American Association for Cancer Research American Association of Pathologists and Bacteriologists American Medical Association American Society of Clinical Pathologists American Society for Experimental Pathology American Society for Microbiology Chittenden County Medical Society College of American Pathologists Infectious Diseases Society of America International Academy of Pathology Massachusetts Medical Society Massacbusetts Society of Pathologists (Executive Cor:~ittee, _,..7) New England Society of Pa t'-:ologists Pluto Club Royal Society of Medicine Society for Experimental Biology and Medicine Tissue Culture Associaticn of America Vermont Medical Societv Board Certification: American Board of Pathology (Anatomic Pathology) 1963 American National Honors: Board Board of of Pathology (Clinical Pathology) Medical Examiners 1967 Special Fellow, ::ational I.^.stitutes of Health, 1963 Royal Society of ^:ecic_ne ^_'ravelinc Fellow, 1971 David Ru;r:coug;^. Scientific Award, 1976 GTR H N 0 10 9 G_'--i

Universitv Service: 1969 Ad Hoc Committee on Medical School Governance 1971-72 Acting Director and Member of Executive Committee, the Environmental Program 1971-72 Chairman, Search Committee for the Director of the Environmental Program 1972 Chairman, Assessment and Chairman Search Committee for Department of Community Medicine Associate Director, National Heart Lung Znstitute Special Center for Research in Pulmonary Disease 1976 Chairman, Search Cc:---,nittee for Department of Medi,._.._ Chairman 1976 Acting Director of the Vermont Lung Center CTR HN 010964

Publications: 1. Reichelderfer, T,E „ Chanock, R.M., Craighead, J.E,, ...:ezner, R.J., Turner, H.C „ James, W, and Ward, T.G.: Znfection of -,an volunteers with Type 2 hemadsorption virus. Science 128: 779-780, 1958. 2. Murnane, T.G., Craighead, J.E „ Mondragon, H, and Shelck:,v, A,: Fatal disease of swine due to encephalomyocarditis v:=::s. Science 131: 498-499, 1960. 3. Craighead, J,E „ Cook, K.M. and Chanock, R.M,: Infect:cn of hamsters with parainfluenza 3 virus. Proc. Soc. Exper. Biol, and Med, 104: 301-304, 1960. , 4. Craighead, J.E „ Shelokov, A., Peralta, P.H. and Vogel, ,'. . Croup-associated virus infection in adults. Report cf =wo cases. New Eng, J, Med. 264: 315-317, 1961. 5, Craighead, J.E „ Shelokov, A., Vogel, J. and Peralta, P.: An outbreak of influenza B in Panama. Am. J. Trop. Me:~, and Hyg. 10: 71-74, 1961. 6. Bell, J.A., Craighead, J.E,, James, R.G. and Wong, D.: Epidemiological observations on two outbreaks of Asian influenza in a children's institution. Am, J. Hyg. 73: 84-89, 1961. 7. Craighead, J,E, and Shelokov, A.: Encephalomyocarditis _rus hemacglutination-i:hibition test using antigens pre:a_ez in HeLa cell cultures. Proc. Soc. Exp. Biol. Med. 108: 823, 826, 1961. 8. Craighead, J.E., Shelokov, A, and Peralta, P.H,. The '_____3-- a possible host for eastern ecuine encepzalitis virus _.. Panama. Am. J. Hyg. 76: 82-87, 1962. 9. Craighead, J,E., Mahonev, E,M„ Carver, D.H., NaFicy, .., and Fremont-Smith, P, . Orc:,r~_s due to coxsackievirus G_. Type 5. Report of a case with isolation of virus f_..... testis. New Eng. J, Med. 267 498-500, 1962. S, =:e 10. Craighead, J. ., Peralta. P.H., Murzane. T.G. and Shelo:tic , A, . Oral infection of swine w_ t^ the encephalc:^yocard_ ,._s J. Infect. Dis. 205-212, 1963. cow! om (DI i own-vt

11, Craighead, J.E., Peralta, P.H. and Shelokov, A. Demon- stration of enceohaiomvocarditis virus antibody in .._-.an serums from Panama. Proc. Soc. Exper. Biol. and med. 114: 500-503, 1963. 12. Craighead, J.E „ Shelokov, A. and Brody, J.: Enterovir::s infections of Panamanian`children. An outbreak of :__.,- myelitis during a 12-month population survey. Am. J. Hyg. 79: 328-335, 1964. ' 13. Hedley-Whyte, E.T. and Craighead, J.E,: Generalized c_-:~.,- megalic inclusion disease after renal homotransplan:.a:,izn. New Eng. J. Med, 272: 473-475, 1965. 14. Craighead, J.E.: Some properties of the encenhalomyoca:_:tis, Columbia SK and Mengo viruses. Proc. Soc. Exper. Bic_. and Med. 119: 408-412, 1965. 15. Craighead, J.E.: Necrosis of the pancreas, parotid and lacrimal glands associated with encephalomyocarditis (E.uC) virus infection. Nature 207: 1268-1269, 1965. 16. Craighead, J.E.: Pathogenicity of the E and M variants of the encephalomyocarditis (EMC) virus. I. Neurotropic and myocardiotropic properties. Am. J. Path. 48: 333-345, 1966. 17. Craighead, J.E.: Pathogenicity of the E and M variants of the encephalomyocarditis (EMC) virus. II. Lesions c= the pancreas, parotid and lacrimal glands. Am. J. Path. 48 375-366, 1966. 18. Craighead, J.E., Sather, G. ., Hammon, W. McD. and DamT._n, G.J.. Pathology of De.^.ct:e virus infections in mice. Arch. Path. 81: 232-239, 1966. 19. Collins, J.E., Craichead, J.E., and Brooks, J.: The rationale for total aar.createctomv in carcino:^a of _.._ pancreas. New Eng. J. Med. 274: 500-602, 1966. 20. Kanich, R.E. and Craichead, ,; .E, . Cytomegalovirus i nfec_:.,.^.s and cytomeaalic inclusion disease in renal homo:.ransp;ant reci^,ents. Am. .,. Med. 40 87-;-8c2, 1966. C TR HN 010966

21. Craighead, J.E.: Growth of parainfluenza type 3 vir::s and interferon production in infant and adult mice. Brit. J. Exper. Path. 47: 235-241, 1966. 22. Craighead, J.E.: Growth of parainfluenza type 3 virus _.^n organ cultures of cvinea pig tissue. J. Bacteriol. 92: 751-761, 1966. 23. Craighead, J.E.: Parainfluenza type 3 virus: A myxovir::s infecting man and lower animals. In: LaGriDDe. Proc. 8th Int'l Congress of Comparative Pathology, Beirut, Sept. 22, 1966, pp. 133-148. 24. Swanson, J.L, Craighead, J.E. and Reynolds, E.S.: Elec==:: microscopic observations on Hernesvirus hominis ('r.e_:es simplex virus) encephalitis in man. Lab. Invest. 15: 1966-1981, 1966. 25. Kline, T. and Craighead, J.E.: Renal homotransplantat'_z-:: A cytological study of the urine sediment. Am. J. Clin. Path. 47: 802-806, 1967. 26. Craighead, J.E.: Polycation effect on virulent non- pathogenic r+ variant of encephalomyocarditis (EriC) Nature 214: 716-717, 1967. 27. Craighead, J.E., Hanshaw, J.B. and Carpenter, C.B.: megalovirus infection after renal allotransplantation. JAMA 201: 725-728, 1967. 28. Craichead, J.E, . Effect of colycat_ons on cro~:t`: a: .. dissemination of the encephalomyocarditis~virus in J. Virology 1: 988-995, 1967. 29. Craighead, J.E. and Bren.^.an, B.J.. Cytopathic effects ..f parainfluenza type 3 in organ cultures of human res. __=_cry tract tissue. Am. J. Path. 52: 287-300, 1968. 30. Craighead, J.E. . Patr.ogenic _ro: erties of ence: ha1c- myocarditis virus plaque variants. Proc. Soc. Exper. Bio1. and Med. 126: 806-813, 1967. L, 1R t 4 t'Y 010967

31. Tegtmeyer, P.J. and Craichead, J.E. Infection of ad::'__ mouse macrophages in vitro with cytomegalovirus. Proc. Soc. Exper. Biol. and Med. 129• 690-694, 1963. 32. Tegurneyer, P.J., Minc, P.M.L. and Craighead, J.-.. C.tc- logical studies on cyto:r,ecalovirus infected mouse cei;s. Arch. fur ges. Virusforch. 26: 334-340, 1969. 33. Craighead, J.E. and Layne, C.: Contrasting effect of polycations on plaquing efficiency of.EMC virus varia::s. J. Virology 3: 45-51, 1969. 34. Craighead, J.E. and McLane, M.F.: Diabetes mellitus: Induction in mice by encephalomyocarditis (EMC) virus. Science 162: 913-914, 1968. 35. From, G.L.A., Craichead, J.E., McLane, M.F. and Steinke, Virus induced diabetes in mice. Metabolism 17: 1154-1158, 1969. 36. Craighead, J.E.: Pulmonary rhinovirus type 13 infection. New Eng. J. Med. 281: 1403-1404, 1969. 37. Craighead, J.E.: Immunol.ogic response to cytomegalovir,-s infection in renal allograft recipients. Am. J. Epid. 90: 506-513, 1969. 38. Craighead, J.E.: Cytopathology of adenoviruses types 7 and 12 in human respiratory epithelium. Lab. Invest. 22: 553-55,57, 1970. 39. Craichead, J.E and Stei.. :e, J. . Diab,etes-__ J in mice ir.fected wi=., the ence:nalomyocarditis virus. Am. J. Path. 63: 119-130, 1971. 40. Craighead, J.E.. Pu1:-.cr.ary c.,'to:^.ecalovirus in_`ection _ the adult. Am. J. Path. 63: 487-500, 1971. 41. Kanich, R.E. and Craichead, Hu.:,an cvto:^ecalov;=_S infection of cultured =ibroblasts. I. Cytocat:oloci:C effects induced by an "adacted" and a"wild" strai.^.. Lab. Invest. 27: 263-272, 1972. 42. Kanich, R. E. and Crai_head, „,F, , Human cvt.^m.ecalc. __.:s infect_on of cult:.r_.. ~_-_,.~l' ~ ~. sequence of a"wilc ' an.A an ac stra_. Lab. Inves`. 27 : 2:'--2c2, 1972. CTR MN 010966

43. Craighead, J.E., Kanich, R.E., and Alemida, J.. Nonviral microbodies with viral antigenicity pro::u~e~ in cytomegalovirus-infected cells. J. Virol. 10: 766-775, 1972. 44. Kanich, R E., Craighead, J.E., and Kessler J.B.: Glomeruli in virus-induced diabetes. Diabetologica 9: 203-209, 1973. 45. Brody, A.R. and Craighead, J.E.: A simple perfusion apparatus for lung fixation. Proc. Soc. Exp. Biol. Med., 143: 388-391, 1973. 46. Craighead, J.E.: Insulitis associated with viral in-fe==ion in immunity and autoimmunity in diabetes mellitus. ed. P.A. Bastenie, L'::cerpta Medica, Amsterdam, 1974. 47. Craighead, J.E.: Lesions of the pancreatic islets of Langerhans in human viral infection and insultitis in encephalomyocarditis virus infected mice (panel presen- tation). Proc. 8th Inter. Diabetes Fed., Excerpta Medica, Amsterdam, 1974. 48. Craighead, J.E., Kanich, R.E. and Kessler, J.D.: Lesions of the islets of Langerhans in encephalomyocarditis virus infected mice with diabetes mellitus-like sy::c:c-e. Am. J. Path. 74: 287-294, 1974. 49. Brody, A.R., Graham, W,G., Kanich, P,.E., and Craig:^ea-~, Cyst wall formation in pulmonary eosinophilic gran;::c-.?. Chest, 66: 576-578, 1974. 50. Brody, A.R. and Craichead, J.E.. Pathogenesis of pL'_:nc::a_: cytomegalovirus ir.fection in immunosuppressed mice. J. Infect. Dis. 129: 677-689, 1974. 51. Craighead, J.E. and D.A.. Genetic influences affecting the occurrence of a diabetes mellitus-li:e disease in mice infected with the encechalomvocarditis virus. J. Exp. Med., 139: 414-426, 1974. I 52. Mossman, B.T. and Craichead, J. .. Topical applicat:,,.. polvcycl..c hydroca_-_ns to c_-"erent_ated res:.ira~c in lot:c-te:m, orca n cultures. in Drocee~_. "s of Battelle Svrr.aosi.:m on E;•. er:^ental Resaira:.orv C_nr__..~- c°nezis a:1Ca. Bloassa;. in •-•n'- "ie^~~~ Lunc Canc"" carcinocenesis and .icassays, Springer-Ver13g, N.Y., __74. CTR MN 0109G9

53. Craighead, J.E.. Disease accentuation after _.._..,..._zat_z.n with inactivated microbial vaccines. J. Infect. Dis. 131:(6), 749-754, 1975. 54. Murphy, G.F., Brody, A.R, and Craighead, J.E.. Monoc:te migration across pulmonary membranes in mice infected with cytomegalovirus. J. Exper. & Molec. Path., 22: 35-44, 1975. 55. Brody, A.R. and Craighead, J.E.: Cytoplasmic inclusic::s in pulmonary macrophages of cigarette smokers. Lab. Invest., 32: 125-132, 1975. 56. Brody, A.R. and Craighead, J.E.: Fine structural feat;:_es of some cells lining air spaces in pulmonary fibrosis. In Press, Virchows Archiv. Pathol., 1976. 57. Mossman, B.T. and Craighead, J.E.: Long-term maizte^:a::=: of differentiated respiratory epithelium in organ c::'__::=e. Proc. Soc. Exper. Biol. & Med., 149: 227-233, 1975. 58. Craighead, J.E.: Animal model of human disease: Diabetes mellitus (Juvenile-and-Maturity-Onset Types) Animal -:::~=_l: mice infected with the M variant of ence_ohalom_vocardi=_s virus. Am. J. Path. 78: 537-540, 1975. 59. Mossman, B.T., Ley, B.W. and Craighead, J.E.: Squa.^.,ou s metaplasia of the tracheal epithelium in organ cult;:_=_. I. Effects of hydrocortisone and B-retinyl acetate. Exp. Mol. Biol., 24: 405, 1976. 60. Brody, A.R., Vallyat:an, N.V, and Craighead, J.E•: Distribution and elemental analysis of inorganic pa___c•_- lates in pulmonary tissue. Scanr.in, Electron ~iic_osc 1976/I. Proc. 9th Annual S,,:nposicm, p. 477-485, 1_ ._. 61. Mossman, B.T., Kessler, J.B., Ley, B.W• and Craighead, '• Interaction of cro__zol_te ashestos with hamster res-__=.=mucosa in organ _..___re. Lab. Invest., 1976, In press. CTR HN 010970

Book ChaDters- 1, Craighead, J.E.: Cytomegalovirus Infection after Re::a: Allotransplantation. In ImmunosuDDressive Theraov, Med. Exam, Pub. Co., Flushing, N.Y., 1971. 2. Kanich, R.E, and Craighead, J.E,: Cytomegalovirus In-fec=ion and Cytomegalic Inclusion Disease in Renal Homotrans-nlant Recipients. In Contribution to Our Understanding o~ ~~_,:^an Cytomecalovirus Infection. Med. Exam. Pub. Co „ Flushing, N.Y., 1971. 3. Craighead, J.E.: Ir.flammatory Lesions of the Islets c~_ Langerhans. In The Endocrine Pancreas, Am. Phy. Soc., 1972. 4. Craighead, J.E. : The Role of Viruses in the Pathoge nes_s of Pancreatic Disease and Diabetes Mellitus. Prog. Med. Virol,, 19: 161-214, 1975. S. Craighead, J.E.: Cytomegalovirus Pulmonary Disease. In Pathobioloav, 5: 197-220, 1975. 6. Craighead, J,E,: Pathology of Islets of Langerhans ir. :"_=a1 Induced Diabetes Mellitus. Ed. Volk and Wellman. In Pathologv of the Islets of Lancerhans. In prepara:._cZ 7. Craighead, J.E. : Virus Induced Insulitis in Experime^,:=__ Animal Models. In I:^.:nu.^.olocical Ascects of Diabetes ! 8. Acta Endocrin. Craighead, J,E.. In Press, 1976. Experimental Viral Diabetes :v!e1lit;s, In The Diabetic Pancreas. Ed. Volk and We1Lman. In Press, 1976. CTR HIN 0 10971

Abstracts: 1, Shelokov, A.I., Craighead, J. . and Brody, J.. T,,7-,e .. poliovirus infection and disease in Panama City. J. Clin. Invest.,39: 1028, 1960. 2. Craighead, J.E „ Peralta, P.H.and Murnane, T.G.: Ora- infection of swine with the encephalomyocarditis (rMC) virus. Fed. Proc „ 20: 446, 1961. 3. Craighead, J.E.: Pathogenicity of the r and r+ varia:ts of encephalomyocarditis (EMC) virus. Fed. Proc., 24: 1063 1963. 4. Craighead, J.E.: Experimental infection of newborn ^::-e with parainfluenza type 3 virus. Bacteriological Proceedings 104: 1965. 5. Craighead, J.E., Kanich, R.E., and Dammin, J.G.: Cyto- megalovirus infections in recipients of renal ho:no- transplants. J. Clin. Invest., 44: 1038. 1965. 6. Craighead, J.E.: Morphologically apparent and inapparent cytomegalovirus infections. Am. J. Path., 48: 44A, 1;66. 7. Collins, J., Craiahead, J.E. and Brooks, J.: The rat::_-na:e for total pancreatectomy in carcinoma of the pancreas. Trans. 46th Ann. Meet. New Eng. Surg. Soc., 46: 58-60, 8. Craighead, J.E.: Viral induction of diabetes mellitus :.n mice. Am. J. Patn., 52: 56, 1968. 9. Craighead, J.E.: Virus cytopathology in the mucosa of =ne respiratory tract. Am. J. Path., 55: 44a-45a, 1969. 10. Craighead, J.E. and Steinke, J.: Temporary diabetes -.n caused by encephalomyocarditis virus. Clin. Research 17: 380, 1969. 11. Kanich, R.E. and Crai nead, J.-.. Role of lysosomes _.. pathogenesis of parainfluenza t~-pe 3 virus-induced les.t::s. Am. J. Path., 59: 48a, 1970. 12. Kanic~, ? . . and Cra _ ^eac, ;, . . : The relationshioi clusion bodies to the _.._racellu_ar maturation „f __- mecalovirus. Am. ;, . Pa th. , 62 • 64, 1.971. CTR h~~`~ 0~~~{~

; 13. Kanich, R.E., Kessler, J.B., and Craiahead, J. . Renal lesion associated with virus-induced diabetes mei'_it~s in mice. Am, J, Path. 66: 60a, 1972. 14. Craighead, J.E.: Workshop on viral infection and diabetes mellitus in man, J. Infect. Dis. 125: 568, 1972. 15. Brody, A.R. and Craighead, J.E.: Pathogenesis of pul^;sr.ary lesions in experimental Murine cytomegalovirus (MCMV) infection. Am, J. Path. 70: 46a, 1973. 16. Heintz, N.H., Mossman, B.T., and Craighead, J.E.: Nutritional factors promoting squamous metaplasia in hamster tracheal explants. In Vitro 10: 373, 1974. 17. Mossman, B.T., Ley, B.W., and Craighead, J.E, Effects „'f hydrocortisone on respiratory epithelium in organ c.._:~=e. In Vitro 10: 373, 1974. 118. Brody, A.R. and Craighead, J.E.: Cytoplasmic inclusions in pulmonary macrophages of cigarette smokers. Amer. Rev. Resp. Dis. 109: 726, 1974. 19. Craighead, J.E. and Brody, A.R.: Monocyte-mediated glomerulonephritis in cytomegalovirus-infected mice. Am. J. Path. 78: 62a, 1975. 20. Brody, A,R., Davis, G.S., Landis, J,N., Graham, W.G, a::'_~ Craighead, J.E.: Intrapul:r.onary migration of monor.ucl__r cells in human interstitial _Dneumonitis. Am. J. P ath , 7° : Ba, 1975. 21. Brody, A.R. and Craighead, J.E.: A mechanism of exLdate formation through an intact alveolar epithelium. In ==ess, Amer. Rev. Resp. Dis. 22. Davis, G.S., Brody, A.R., Landis, J.N., Graham, W.G., Craighead, J.E,, and Green, G.M. : Prediction of i.^.-f_a--.- matory activity in interstitial pneumonitis by bronc^o- fiberscopic pulmonary lavage. Clinical Researc: 22: -1975. 23. Davis, G.S,, Brodv, A.R., Landis, J.N., Graham, W.G., Craichead, J.E,, a..6 Green, G.', . 4uant_tat_.,.. ,.~ _..- fla^%_nator, acti•._ _ _.. _..terst_tial pneumonitis by bronchofibersconic :ulmonary lavace. In Press Chest, 1975. C1s~ HIN 0109- "3

24. Davis, G.S., Landis, J.N., Brody, A.R., Graham, .G., Craignead, J.E „ and Green, G.M.: Character_stics diffuse lung disease reflected by pulmonary lavage. In Press. Amer. Rev. Resp. Dis., 1975. 25. Mossman, B.T „ Ley, B.W. and Craighead, J.E.: Effects of hydrocortisone on respirato`ry epithelium in orcan r culture. In Vitro 10: 373, 1975. 26. Heintz, N.H., Mossman,B.T, and Craighead, J:E.: Nutritional factors promoting squamous metaplasia in hamster tracheal explants. In Vitro 10: 373, 1975. 27. Mossman, B.T., and Craighead, J.E.: Interaction of crocidolite asbestos with the mucociliary epitheli,= of the respiratory tract. Proc. Am. Assoc. Cancer Res. 17: 88, 1976. 28. Ezerman, E,B., Adler, K.B. and Craighead, J.E.: Isolation of epithelial cells from hamster tracheal respiratory epitzeli.:m, In Vitro 12: (4) 319, 1976. 29. Brody, A.R., Dwyer, D.N., Vallyathan, N.V. and Craighead, J.E.: Elemental content of granulomata in biopsied and autopsy lung tissue. Accepted for publication, Amer. J. Pathol., 1976. CTR HN 0 109~~~•