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CTR HN 010939

CURRICULUM VITAE VITAL STATISTICS Michael James Brennan Married 8 Children Date of Birth: June 11, 1921 Birthplace: Mt. Clemens, Michigan Office Address: 110 E. Warren Avenue, Detroit, Michigan 48201 Home Address: 1168 Three Mile Drive, Grosse Pointe, Michigan 48230 PRESENT POSITIONS AND ':TL:S President and Medical Director, The Michigan Cancer Foundation Professor of Medicine, Wayne State University School of Medicine Director, Comprehensive Cancer Center of Metropolitan Detroit PRE-MEDICAL EDUCATION Bachelor of Science in Chemistry, University of Detroit, 1942 Fellow, Graduate School of Chemistry and Physics, University of Detroit, 1942-43 MEDICAL EDUCATION Loyola University College of Medicine, Chicago, Illinois, February 1947, M.D. Internship, Henry Ford Hospital, July 1948 to June 1951 Associate Physician, Hematology Division, Henry Ford Hospital, July 19S: to June 1952 Chief, Medical Service and Laboratory Service, U.S. Army Hospital, Fort Monmouth, New Jersey, August 1952 to August 1954 Chief, Oncology Division, Henry Ford Hospital, August 1954 to March 195c Certified, American Boar~ of Internal Medicine, April 1954 CTR HN 0 10940

CURR:C::LUM VITAE Page Two HONORARY DEGREES Doctor'of Science, Eastern Michigan University, April 21, 1979 TEACHING POSITIONS Instructor, Advanced Inorganic Chemistry, Loyola University, Chicaco, 1945 Associate Professor in Biochemistry, University of Detroit Dental School, 1947 Instructor in Bacteriolocy, University of Detroit Dental School, 1947 Professor of Medicine, 'A'ayne State University School of Medicine, 1966 to present MEDICAL SOCIETIES American College of Physicians, Fellow 1962 American Association for Cancer Research American Society of Hematology Endocrine Society Central Society for Clinical Research A,merican Society of Clinicai Oncology American Society for Experimental Pathology Society for Experimental Biology and Medicine Society of Nuclear Medicine Reticuloendothelial Society American Federation for Clinical Research National Society for Medical Research CTR HN 010941

CJRRiCiLU'" VITAE Page Three MEDICAL SOCIETIES (continued) The Society of Surgical Oncology Royal Society of Medicine, Fellow 1966 American Medical Association Michigan State Medical Society Wayne County Medical Society Michigan Society for C';nical Research Detroit Physiological Society PARA-MEDICAL AND SCI=.`+T:=IC ORGANIZATIONS American Association for the Advancement of Science New York Academy of Science Board of Directors, Science and Engineering Fair of Metropolitan Detroit, 1979 EDITORIAL BOARD ME""?=-"- Cancer Chemotherapy Re:crts 1960 Cancer Research 1964 - -resent Year Book of Cancer Editorial Advisory Board, Cncology News PROFESS I ONAL AND SCI ,;P?0 i NTME,';TS Breast Cancer Task Force, Nlational Cancer Institute, 1969-71 E;ide~iology Committee, Ereast Cancer Task Force, 1972-1976 C T R H N 0 10 9 4..?.

Page Four PROFESSIONAL AND SCIEti7;riC APPOINTMENTS (continued) Committee on' Cancer, American College of Physicians, 1965-1969 Committee on Cancer Treat.ment Facilities, American College of Surgeons, 1968 National Advisory Council, Regional Medical Programs, Memoer, 1968-1y72 Breast Cancer Virus Segr:ent, Special Virus Cancer Program 1970 Clinical Cancer Training Committee 1975 Member, Ad Hoc Scienti':c Advisory Committee on Breast Cancer, American Cancer Society, 1964 Member, Public Health Committee, Wayne Council Medical Society Me,,ber, Comprehensive ~ealth Planning for Southeastern Michigan OFFICERSHIPS President, American Society of Clinical Oncology, 1965 Board of Directors, r,mer~can Association of Cancer Research, 1971 Chairman, Regional rcv ;:~ry Group, IMichigan Association for Regional Medical Programs, 19;5:-,:73 EDUCATIONAL, FRATERNAL -,tiC~ CIVIC GROUPS Economic Club of Detroi: American Association of ~r,iversity Professors Sigma Xi, National Honor Society Alpha Sigma Nu, Nationai ,iesuit Honor Society Catholic Physicians' Guild, Archdiocese of Detroit Past President, Catholic ?hysicians' Guild CTR HN 010943'

1.~.......l.w~'.J i ~ t ,. ~ Race Five EDUCATIONAL, FRATERINAL ='~C !'?VIC GROU°S (continued) Metropolitan Alumni Clut, University of Detroit Past Presicent, politan Alumni Club Metro- Grosse Pointe Park Plan Comnission Corktown Charities Guild Alpha Omeaa Alpha Honor Society, Loyola University Stritch School of Medicine 1972 Stritch Medal Winne- (Awarded annually to one individual for ou- standing achievements in -.eaicine and in research) April 25, 1975 First alu~rus to receive the University of Detroit's President's Cabinet Medal Fellow, Engineering Socie:y of Detroit, June 3, 1977 Society of Health and ~u-.an Values Board of Directors, Guest Hcuse Board of Trustees, Xerc_: :.;,llege of Detroit BOOKS Michael J. Brennan ar,c e:i'liam L. Sir:rsen, Editors. Bie'ocical ?nte-ac:ions in Normal and ';eoolas• I-!enr, =ord !-'os;,'tal . „ Little, Brown ane Comoany, i=c2. Michael J. Brennan, Editor. Breast Cancer Research. 1Jorkshoa on Biolonv of Human Cancer, No. 4. :-~eneva, International Union Against Cancer, 1977. Michael J. Brennan, Charles `!. McGrath, and Marvin A. Rich, Editors. Breas- Cancer: New Conceots in ::ioloov and Control. Academic Press, New York, New York, 1980. Charles M. McGrath, Michael J. Brennan, and Marvin A. Ric7, Editors. Cell Bioloav of Breast Cancer. Academic Press, New York, New York, (in press, 1981). C! R IHIN 010944

PUBL:SHSD ~'-RT:CLcS Page Cne Michael J. Brennan, M.D. 1. R.W. Smith, R.R. !"ar=lis, M.J. Brennan and R.W. Monto. The Influence of ACT:; and Cortisone on Certain Factors of Blcod Coagulation. Scienc:, Vol. 112, No. 2907, pp. 295-297, September 1950. 2. M.J. Brennan, R. Mcr,:o, C.H. Mangun and F.W. Hartman, Therapy of Malignant Diseases Nith Proteinimine (A new agent), Journal of Laboratory and Medicine, Vol. 38, No. 5, pp. 794-79^, Novemoer 1951. 3. Michael J. Brennan, zaymond W. Monto and Harold C. Shafer. Hemorrnagic Diatnesis Due to Ac-Globulin Deficiency. The American Journal of Clinical Pathology, Vol. 22, No. 2, pp. 150-154, February 1952. 4. Raymond W. Montc, -.a-oid C. Shafer, Michael J. Brennan and Jonn a. Rebuck. Neutropenia Treated by Adreno- corticotrophic rcr-cr,e and Splenectomy. New England Journal of Medicine, Vol. 2=~, pp. 893-896, June 5, 1952. 5. M.J. Brennan and =.~. Yonto. The Use of Protein-Bound Nitrooen Mustard (proteiniin the Therapy of Malignant Diseases. Clinical Researcn = =ceedings, Nove^ber 1952. 6. P,aymcnd W. Mont;,, W. Bales and ""ichael J. Brennan. He-°~itary Cap;llary „ . „ . Tne Journai of tne Micni^an State Mecical Society, Vol. C,', pp. 62-64, January 1953. 7. Raymond W. Monto, ,;cnn ~. Rebuck and Michael J. Brennan. Crystalline B12 inhalation Tneracv in Pernicious r.nemia. The kmerican Journal of the Medical Sciences, 'lcl. 2_55, pp. 113-119, February 1953. 8. Morris Goodman, Micr.ael J. Brennan and William L. Simpson. Orosomucoid C-Reactive Protein a^.d rlburnin ;'ariar,ces 'leasures Irrmunocnemically in Cancer Patients. :. "e:nodology. Proceedings of the i,merican Association for Cancer Research, Vol. 2, p. ill, April 1956. 9. M.J. Brennan, K.C. !"c-':;nnis and L. Preuss. Experience with Ir.tra- Cavitary Radiogolc a: ~-enry Ford ;-osoital. Henry Ford rospital Medica l Bul le:in, .,,,. .._-93, June CTR HN 0 109415

Pi,;SLIS~,EJ ART:CL__ Paqe Two Michael J. Brennan, M.D. 10. Morris Goodman, David S. Ramsey, William L. Simpson, Donald C. Remp, Daniel H. Basinski and Michael J. Brennan. The Use of Chicken Anti- serum for the Raoid Determination of Plasma Protein Comoonents. I. The Assay of Human Serum Albumin and Gamma Globulin. The Journal of Laboratory and Clinical Medicine, Vol. 49, No. 1, pp. 151-164, January 1957. 11. William L. Simpscn, Morris Goodman and Michael J. Brennan. Considera- tions of Selectec Svstemic Reactions to Cancer as 0bjective :ncices of Response to Tneral,v. Proceedings of American Association for Cancer Research, ';ol. 2, No. 3 p. 250, March 1957. 12. William L. Simpson, Michael J. Brennan and Morris Goodman. Objective Indices of Response to Therapy in Breast Cancer Patients. Proceedinos of t^e II International Svmposium on Mammarv Cancer, Editor, Lucio Severi, University of Perugia, pp. 399-412, July 1957. 13. Morris Goodman, David S. Ramsey, William L. Simpson and Michael J. Brennan. The Use of Chicken Antiserum for the Rapid Determination of Plasma Protein Co^.:,onents. II. The Assay of Human Serum Orosomucoid. The Journal of Laboratory and Clinical Medicine, Vol. 50, No. 5, ;,p. 758-768, November 1957. 14. Michael J. Brenn;-r., Richmond W. Smith, G. Betanzos and Robert C. Tinker. Implica:icns of Vaginal Cytology and FSH Excretions in Breast Cancer. ?rc--. American Association for Cancer Researcn, Vo i. 2, p. 283, 1958. 15. Michael J. Brennan, Guillermo Betanzos and William L. Simipson. Plasma Proteins in !'alignant Disease. Postgraduate Medicine, Vol. 24, No. 1, ,;. 35-41, July 1958. 16. Victoria L. Beckett and Michael ,'. Brennan. Treatment of Advanced Breast cancer with Fiuoxymesterone (Halotestin). Surgery, Gyn2cology & Obstetrics, Vol. 1-C9, pp. 235-23?, August 1959. 17. M.J. Brennan, V.K. 'laitkevicius, W.A. Ceardoff and L.E. Preuss. Reticuloendothelial Pnagocytic Activity in LymphoTatosis and Disseminated CarcinoTatosis; Colloidal Gold Clearance Rates Before and After Thera;y. Prcc. w-nerican Association for Cancer Research, Vol. 3, p. 98, 195C. CTR HN 0 1094 6

PUBL :SaED ARTICL=S Page Three Michael J. Brennan, M.D. 18. M.J. Brennan. The IndicationS for Cancer Chemotherapy. The Journal of the Michigan State Medical Society, Vol. 59, pp. 588-590, April 1960. ' 19. M.J. Brennan and 'l.K. Vaitkevicius. 5-Fluorouracil in Clinical Cancer: Experience with 155 Patients. Cancer Chemotherapy Reports, No. 6, p-.. 8-11, 1960. 20. Michael J. Bre^ran and Stephanie Horeglad. Natural History of Cancer and Chemotherap_v. Proceedings of the Fourth National Cancer Conference, pp. 2~3-208, Minneapolis, September 1960. J.3. ippincott Company, 1960. 21. M.J. Brennan and '~.L. Simpson. Serum Proteins in Breast Carcinoma: Effects of Andrec?n ;herapy. Biolo ical Activities of Steroids in Relation to Cancer, Vol. XVI p, i, taitea by Gregory Pincus and Erwin Voll-mer, ;,;acemiq Press, New York, 1960. 22. M.J. Brennan, V.L. Beckett, J.E. Kelly and G. Betanzos. Treatment of Advanced Mammary r_r,cer with 3;-, 17F-Androstanediol. Cancer, Vol. 13, No. 6, pp. 1195-i~~0, November 1960. 23. M.J. Brennan, V.K. 'Jaitkevicius, and J.W. Rebuck. Megaloblastic Anemia Associated .:ith Inhibition of Thymine Synthesis (,Observa- tions during 5-fl;.cr;,uracii treatment). Blood, Vol. 16, No. 5, pp. 1535-1545, ';cve~-ner 1960. 24 . V.K. Vaitkevicius, `!.J. Brennan, V.L. Beckett, J.E. Kelly and R.W. Talley. Clinical :valuation of Cancer Chemotnerapy with 5-Fiuorouracil. Cancer, Vol. 14, No. 1, pp. 131-152, January, February 1961. 25. V.K. Vaitkevicius, ~.~. Simoson and M.J. Brennan. Freeze Preservation of Enzymatically Prepared Tumor Cell Suspensions and Their Use in Tumor Transplantation. Cancer Research, Vol. 21, pp. 187-192, February 1961. 26. R.W. Talley, M.J. Brennan, V.K. Vaitkevicius and J.'-:. Kellv. Intra- arterial Chemotherapy of Malignant Disease. Henry Ford 'r,ospital Medical Bulletin, Vol. 9, No. 1, pp. 1-10, Marcn 1961. CTR HN 0 109 4'17

PL'BLiAicT:CicS Pace Four Michael J. Brennan, M.D. 27. V.K. Vaitkevicius, R.W. Talley, M.J. Brennan and J.E. Kelly. Chemo- theraDy of Advanced Ovarian Cancer. Journal of the Michican State Medical Society, Yol. 60, pp. 492-496, April 1961. 28. Michael J. Brennan. Investigational verus Practical Cherr,otnerapy. Journal of the Michigan State Medical Society, Vol. 60, p. 509, April 1961. 29. R.W. Talley, J.~. <e'ly, M.J. Brennan and V.K. Vaitkevicius. Clinical Study of 6n-Methyl-y,-Fluoro-l7-Acetoxy-21-De~-xyprecr,isolcne ;U17323) in Human Breast Cancer - Preliminary Report. Cancer Chemottierapy Reports, No. 12, :p. 59-62, June 1961. 30. M.J. Brennan. Imciications of Hormonal Studies in Ambulatorv Post- menopausal Women with Breast Cancer. Anno Accademico (Ann. "'ed. Perugia), Vol. 53, pp. 361-368, 1961. 31. R.W. Talley, V.K. 'laitkevicius, M.L. Reed and M.J. Brennan. Cytosine Arabinoside; Hu,-an ?narmacology and Toxicity. Cancer Res. ?roc. 8: 366, 1962. 32. Michael J. Brennan, ~illiam Prycrodko and Stephanie Horegiad. Quantitative StuCi:_ cn Spontaneous Tumors. Bioloaical Interac•.ions in Normal and '1ec.'as:ic Growth. Little, Brown ane ComGan,l, i~o , PP. 7-`~i 4a-. 33. V.K. Vaitkevicius, ". Sugimoto and M.J. Brennan. The Effect cr' Inflam- mation on Tumor Es:aolisnment and Growth. Biolooical Interactions in Normal and Neooias:ic Growth. Little, Brown and Company, 1962, Pp. io1-7 c: 34. V.K. Vaitkevicius, ?.~. Talley, J.L. Tucker, Jr., and h1.J. Brennan. Cytological and Clinical Observations During Vincaleukoblastine Therapy of Disseminated Cancer. Cancer, Vol. 15, No. 3, March, April 1962, pp. 29»-3C6. 35. Michael J. Brennan. The Problems of Affluence for Cancer Research and Cancer Control. Ce^tinued Education Series 106, University of Yicnigan Scnool of Public Health Monograpn Cancer Control, pp. 192-196, 1962. CTR HN 010946