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. TOBLCCO INDCSTRT RESr.A.RCH COMQTrI.t CONFIDMT1-IAL R'..PORT.' TOBACCO I2.'DUST2Y RI:SEA.RCE COMFIMaTING MAY 8, 1958 Attendance Tiaothy V. Ha.-tnett, Chairman Paul M. Hahn F. S. Royster Emery H. Levis Albert Clay Paul D. Goddard Samklel C. Linton Bovran Gray William P. Schweitzer Stephen Stepr.ano J. B. Hutson J. Whitney Peterson John Vance Hevitt John W. Hill Richard W. De..-rov Carl G. Tbonpson Jr. C. C. Little, Scientific Di.rector R. C. Hockett, Associate Scientific W. T. Hoyt, Executive Secretary 6--,44. a- // L The American Tobacco Co--,any, Inc. Bright Belt Warehouse Association Brown & Willias.son Tobacco Corporatio: Burley Auction Warehouse Associaticr, Burley Stabilization Corporation }6as-yland Tobacco Growers Association R. J. Reynolds Tobacco Co=zy Peter J. Schweitzer, Inc. Stephdr:o Brothers, Inc. Tobacco Associates, Inc. United States Tobacco Conpa=,y Conboy, Hevitt, 0'Brien & Boardrsn Bill a.nd Knowlton, Inc. w u n w M R n n Director 1. ltr. Hartnett opened the seeting. He reminded those present'tha: at the November meeting of the TIRC, a budget for grants was approved in the azaunt of $500,000.00 for the year 1958. It was decided sisultaneously that the budgeting of all expenses over and above the funds for grants be left to the Executive Co=mittee. As a result of this, the total TIRC budget has now been established by the Executive Coasaittee in the amount of $882,537.00, which includes the $500,000.00 for grants. The 1958'budget was approved in the amount of W2,537•00. 2. Grants and renewals awarded by the Scientific Advisory Board, in the amount of $219,643.60 since the Nove.ber 1957 aeeting of the TIRC, were approved. Th:s brings the total aaount of grants and renewals approved by the TLRC, since its inception, to a total figure of $2,147,616.70. CTR 6329 THIS DOCUMENT SUBJECT TO AUC. 20, 1985 NDN • DISSEMINATION ORDER IN ROGERS AND DUKE CASES. CONFIDENTiAL: ]dINNESOTA TOBACCO LITIGATION [.. ! R f 1 t'`t 00,3924

2 THIS DOCUMENT SUBJECT T0 AUG. 20, 1985 NON•DISSEMINATION ORDER IN ROGERS AND DUKE CASES. ~, 2L-. Hartnett coam:ented on the last meeting of the Scientific Advisory Board in Charleston, S.C. in February. On that occasion a memher of the Board, vao had been unable to attend, had written a letter.vhich was read at the neeting. The letter objected to public statenents vhich had been issued, and indicated t:.at unless a sore distinrt divorce could be established between the SAB and TLgC the member felt he could not continue to serve on the Bcard. He vas joined in this by two other Board mr~oersA lir. Hartnett explained that since this situation had arisen the matter h+ed been ironed out satisfactorily, and there was cu_=ently no disposition on the part of the Board me^.bers to resign. Two actions can be expected however, which have the approval of both Dr. Little and A'r. Ea..'tnett. One vould be terms of office for SAB members; and the other the election of a chai:•.a^n to the Board other than Dr. Little, thus separating the chair-.snsh.p of the Board from the office of Scientific Director. b. The Seventh International Cancer Congress, which vill be held in London in July, was discussed at some length, and the Chairrs.n advised that it is pla:-ned to have Drs. Little, Hockett, Wilson ard t!r. Thcmpson of Hi11 and Knowlton, Inc. attend. Mr. Hartnett also outlined visits vhich have been made by Dr. Little, Dr. Hockett and the Executive Secretary to 6overnWent officials with the thou_:t of creating better l:aison, and with the hope of seeing that the Veteraas Administration Study vas released in a dignified and unbiased aa^.ner. ~. Dr. Eockett repc=^ted on the status of the research prog:an and the grants conducted vith:n its framevork. He eL-.-hasized that in the work done tht.s °a-, nothing had occurred to support the anti•ciga.rette theory or to alaa-m the tebacco industry. 6. Yx. Darrov of Eill and Knowlton, Inc. covered the status of the public relations situation. (See Attachment i1.) Z. Dr. Little gave a resume of recent scientific facts relating to tobacco and health, and described the evolution and policy of the Scientific Advisory Board. Re explained that in the beginning of the progran great reliance had to be placed upon applications by worthy investigators. Nov, however, lung cancer applications are not pursued unless they show worthiness in the use of a new technique or indicate that they vill izplement one of the three basic approaches as follows: (1) (2) (3) Assaying derivatives of tobacco in ani=l work. This calls for looking tovard the standardizing of bioassay methods. He described the purposes of the conference being held on May 9th on carcinogenesis and bioassay. Tissue culture. P:ychcicgical differences between smokers and nonsmokers. heavy staokers, aoderate C T R G3'0 CONFIDENTIAL: MINNESOTA TOBACCO LITIGATION CTR HN 0039-25

3 THIS DOCUMENT SUBJECT TO AUG. 20, 1985 NON•DISSEMINATION ORDER 1N GERS AND UKE CASES. 8_. Dr. Little presented to the TIRC the slides and statistical data, vhich be had previously presented at a Weeting of the national Acadery of Arts a:.d Sciences in aashington on April 28, 1958• att. cTR F'.3 .31 CONFIDEN'fIAL: haKNESOTA T06ACCO LITIGATION [s tsh, t t!'t 0031926

. HILL AxD KNOWLTON, Ixc. 1985 NON•DISSEMINATION ORDER IN GERS AND pM C,ASEg, CO'1FIDt??Z4L ATTAC?*LT'T #1 PUBLIC REIATIONS RE?ORT to the TOBACCO MUST:q7 RESEARCH COIrTiZZ= Thursday, May 8, 1958 Public Relations Activities Renewed interest by writers sndd publicationa is being shown in the subject of tobacco use and heal•.h. This is reflected in the nu.:ber of inquiries received for info:~tion and nateria2. Scnet•.es, interest dvindles away. Various news stories, including scientific reports, keep the sub'-ct a1:ve. One rsjor =rablem rerains: the effort to r8lntain balance in reports on tobacco and health, while encou:aging attention to favorable stories. Aaong pending projects are: 1. Hovard Cohen, freelr.nce vriter, is working on a piece for PAGPI.NT along the lir.e of su;.erstitions about tobacco versus scient:::c fact. Fie has Interviewed Dr. Ho.kett and tt; . fis.-tnett, an d has been given considerable material to work with. 2. Fred fiodgaon, freelance writer, has a contract vith St. tdartin's Press to do a book on tobacco, tentatively entitled, "T'he Great Tobacco Question." He has arsssed considerable naterial, rang:n5 from • health to historical, nasiur'acturins, additives and flavorings. 3. Metropolitan Newspaper Group, a syndicate, wanted to do a picture story shoving hov to smoke to avoid health dangers. Syndicate editor has now changed this to "Bow to Get the Mast Pleasure Out of bmoking. " k, THE RF11DEi't'S DIGEST. A new fi,lter piece is scheduled for July. This is apparently another review of the Snell tests. 5. Alton Blakeslee, science editor of The Associated Press, is interested in interviewing sone TIRC grantees and writing up what they are doinR. This is being explored with him. 6. Scientific Exhibit for the Scientific Advisory Board has been revised and there are nov two exhibits being shown at aedical r_eetinbs, both local and national. CT R G33; CONFIDENTIAL: TflNNESOTA - TOBACCO LITIGATION C"f' R (vI i.. I 003927

• 2 - THIS DOCUMENT SUBJECT T0 AUG. 20, 1985 NON•DISSEMINATION ORDER t .i=iE GA .;E3, t 7. TOBACCO AND HFALTfi in the next issue, due out in early June, vill feature discussion of statistical studies, primarily the analyses by Dr. Joseph Berkson and Sir Ronald Fisher. ' .8. LIFE Magazine story, in making for several months, has now been dropped. Editors set out to try to show filter tips had revolutionized the industry fron top to bottom, but decided the story did not work out at this time. ~ 9. Hediauetric Institute Su.-vey. This group is re-questioning its panel of doctors concerning attitudes toward smoking to obtain cosvarison vith si.milar survey conducted last year. This questionnaire has gone out a.nd results are being tabulated now. Report expected early in June. Highlic_.hts of Recent Activities Among developae.^.ts since the last TJ~tC meeting are the follovir.g: 1. Dr. C. C. Little -- Talked at dinner meeting of the Greensboro Academy of Medicine, March 27. His talk and interview covered by local press and Associated Press story was sent out. Also talked to Sigz-a }L SYaternity of University of Ma_-yland and press story handled for the University of Ma_-yla::d to i7ashingron papers and correspondents. Press suamary of paper delivered at the Fational Ace.demy of Sciences in Washington, Monday, April 28, was prepared and reproduced for Director of Public Relations of Acade--,+ who haazdled distribution. 2. Dr. Hockett -- Appeared on a program of the A^erican Cancer Society, Northern New Jersey Chapter. Drs. Wynder and Spain were also on the program. No news coverage was given the meeting. Also addressed the Advertising Men's Post of the American Legion in New York, and his talk received good press attention and was carried by the Associated Press. 3. Haag-Haraaer. Dr. H. B. Haag of the Medical College of Virginia and H. R. xar.mer, research director of The American Tobacco Ccmpany, reported at the Southern Medical Association meeting in November on a scientific study of a tobacco company's employees. This showed that though they smoked nearly twice as.mary cigarettes as the average smoker, they lived longer and had lover cancer and heart disease rates than the general population. This received widespread press attention. 4. Dr. Morton Levin, the New York State Health Depa--t=ent's First Deputy Cosmissioner of Health, addressed the American Public F.ealth Association's annual meeting in November and urged state education progr- s ard labeling on cigarettes. Earl Ubell of the 21Eo' YORK FCtnLJ TR:?UN'E gave the only major news attention given to this talk. Several newspapers ha.d editorials decrying an anti-smoking campaign proposed by Dr. Levin. r,tR f33;3 CUNFIDENTIAL: EvIINNESOTA TOBACCO LITtGATION r+ TR MN 0031926

THIS DOCUMENT SUBJECT TO AUG. 20, 1985 NON•DISSEMINATION ORDER - 3- IN O~t GERS AND UK CASE$, Att. _= 5. TSE A'.'LANT'IC M?NT4'..Y in Decersber ca.: ied Dr. Little's ar ticle, ' "The Public ar.d Saoking." A release was issued by the magazine's circu?at:c.^. agency. Copies of the article anfl release were distributed to the press. Reprints were sent to all doctors and dentists and others along with TOBACCO AJ+D nALTS. 6. The Az:erican Cancer Society issued Its paa•phlet, "To Smoke or Not to SaoYe." This has resulted in fair publicity, issued mainly by local chapters. 7. The Z'rRC Annual Report was issued last December and received substantial publicity. The Report continues to be distributed in ansver to inquiries and at the TIRC exhibits. 8. Sir Ronald Fisher, described as "the father of nodern statistics," speaking befcre the Aserican Association for the Advanceaen;t of Science in indianapolis, questioned the statistical link between cigarettes and lung cancer. Eis talk received a great deal of publicity across the country. A press release was made availabie by Michigan State University, where Sir Ronald was a visiting professor in the College of Arts and Science. The Spring issue of The Centennial Review of Arts & Science also carried a 1•u'? artic'_e by Sir Ronald Fisher on statistics, and this FaFer was aa.de available'to science and other writers for news treatnent and cczzrent. 9. The Jaaua.ry issue of ARGOSY cz.^ried an article, w'hy Shouldn't You Smoke?" by i_-ic PJorthr:p, author of the recent book "Science Locks a: S=oking." Assistance was given in the preraraticn and distribution of a press release on this a_rtic'e. 10. The New ~:cland Jo~-r~1 of Meaicine ce..: ied an editorial labeling 2D?ACCO ;XD Fd;.L c as a propaganda irstr•=ent and criticizirg its purposes. 11. The forr..al report of the Blatnik Co=-.:ttee was issued with a press release and received substantial publicity, a11 of vhich was adverse to the advertising claizs and FTC regulations, but did not take a positicn on the health issue. 12. The final reports of the Aasmond-F.orn atudy were published in the Journsl of the Arer:car b.edical Associatiorr in t•.o parts. These were substantially the same rerorts given by Fi~:=ond and Horn in June before the A.M.A. The authors, however, did not state, as they had in the past, their opinion that asa:ti:.a was a cause of lung cancer, or a.n,v other disease. Only two stories htve been seen so far. Both stories, based on an Internatioral News Service dispatch, were on the first article only and were comperatively :nocuous. Tne AAerican Medical Association did not nention either article in its reTxlar weekly press release on the Journ=l. C1R 6334 CONFIDENTlAL: tdINNESOTA -TOBACCO LITIGATION C'(` R HN 0 03 9 2' 9

~. ITH.15 DOCUMENT SUBJECT T0 AUG. 20, - 4 - E965 NON•DISSEMINATION ORDER M. WAND UKE CASES, Att. 13. The American Cancer Socie`.y conducted leading science vriters on a tour of institut:ors where cancer reseaich was being investigated. Among people intervieved in the course of this tour were the following: Dr. Frank FiFge of the University of Ya.rylend, who said he doubted a direct link between cancer ar.d smoking. Be further stated that "we do not ano•: for sure that giving up stn,king in the attempt to decrease the incidence of lung cancer may not sti=u.!ate factors associated ti-ith other ferr.s of cancer." This interview received vide press ccvera6e, and has been further distributed. 1`tr. Fred G. Bock (".'IitC grantee) at Rosvell Park >'!e=orial Znstitute re;.orted that he bad been unable to obtain lung cancers in n;ce kept in smoking cham ers. This was picked up by one vire serwice but was not extensively featured. Dr. B. L. Freed2a^.der (TIRC grantee) c_* Yauat Zion Hcspita=, San Francisco, repo:rel on his research to the effect that smoking tay deplete the asount of niacin in the hursn system, and a niacin de_*iciency in scne ani=&:s has led to lung cance_r. '!'ne additicn of ,rita:ins to the diet serves to correct the niacin deficiency ar.d any harsZti.l effects that =y result therefra:.. Dr. Freedlan.:er was accorded a good press on this also. Dr. Paul Kotin (a aembe_- of the Scientific Advisory Bca.:d) was reported by the Associated Press to have said that if cige.rettes were abolishe:! there would be a decrease in the anount of lung cancer ar.nually, b;:t that the arount would be i:L°initesl-a'_. Dr. Kotin, _n his' lnter^riew with scie.^.ce 4: iters, made no mention of cigarettes until pointedly asked by one of the reporters present about w:"-t would happen if clgarettes were abolished. xe contends his statenent was that any fair-aLnded person would acknowledge that the elinin ation of cigarettes nic_!a reduce the ar_ount of lung cancer but that, even if it vould, in his opinion it would be a negligible amount. T1he AP version received fairly wide use in the press, but more accu,.-ate re;.crts of his interview have appeared in many papers, including a special feature in 2HE CFiICAGO AknL::iICAN. lb. Dr. Clark Fteath published a paper in the February issue of the . AMA Archiv^s of Interr.al 1•Se3icine entitled "Di.*ferences Between Smokers and pon-Snokers, resul:ing from a T1RC grant. This paper enrhasized that there are basic differences between people who choose not to smoke and those who -4o smoke. This was called to the attention of science writers aad received a good press. 15. Dr. Joseph Berks_on published a paper on smoking and lung cancer in the karch issue of the Journal of the American Statistical Associat=on, in which he rejected the thesis „hat snoking is an iaportant cause of lung cancer. This was sent to science writers and resulted in several good pieces, ir.cludir.g a full colun_ in the Sunday 11174 YORK TLv=-. , C I R 6335 CONFIDENTIAL: MlNNESOTA TOBACCO LITIGATION C I xR H N 0 0r,S 123 f 01

-5 - QHtS DOCUMEM SUBJECT T0 AUG. 20, 1985 MON•DISSEMINATION ORDER IMSQERS AND UKE CASES, Att. A' 16. The Anerican Association for Car.c4r Research and the Federation of American Societies for Experimental Biology met in Philadelphia in April. On one day, seven papers were given on resesch into tobacco, especially in relation to cancer. Only one of these received any press attention and this vas meager. Although the meeting was monitored for possible bad press, no statement or action vas necessary. 17. Dr. Wynder delivered a paper in Los Angeles at a meeting of the Californla Medical Society, dealing with the results of a study he had conducted in various hospitals under the auspices of the Seventh Day Adventists. Again, Dr. Wynder attempted to show a connection between smoking and lung cancer as vell as heart disease by indicating that Sevent-h Day Adventists' death rate for these diseases was less than the average due to the fact that the Adventists do not sr_cke. A four-page gublicity release vas issued in New York and given considerable attention, so that a TIRC comment vas issued. This vas used in most stories seen. This report vill a.gain be given in =re detail at the Internztions.l Cancer Cc:..S3 ess in Lonflon. C T R E;3 36 CONFIDENTIAL. iti!lNNESOTA TOBACCO LITIGATION CTRHN 0039 3 1