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t , Tos•cco IwvsrxY R.EsE.xca CoMmn-EE THIS DOCUMENT SUBJECT TO AUG. 20, 1985 NON•DlSSEMINATION ORDER IN ROGERS AND DUKE CASES. 6' .yiC.. # CONFIDENTIAL REPORT //F TOBACCO INDUSTRY RESEARCH C&?rtITi~E L:EETING NOVEYSER 3, 1955 Attendance Timothy V. Hartnett, Chair^ian Paul M. Hahn F. S. Royster Emery M. Lewi s ,Albert Clay Paul D. Goddard W. T. Reed, Jr. William J. Halley Samuel C. Linton 0. Parker McComas C. S. Stephano J. B. Hutson J. Whitney Peterson Freeman J. Daniels John Vance Hewitt The American Tobacco Company, Inc. Bright Belt Warehouse Association Brown & Williamson Tobacco Corp. Burley Auction Warehouse Assoc. Burley Stabilization Corp. Larus & Brother Company, Inc. P. Lorillard Company, Inc. Maryland Tobacco Growers Assoc. Philip Morris, Inc. Stephano grothers, Inc. Tobacco Associates, Inc. United States Tobacco Company Perkins, Daniels & Perkins Conboy, Hewitt, O'Brien & Boarw:.an John tY. Hill Hill and Knowlton, Inc. Richard 'N. Darrow Leonard Zahn Dr. Clarence Cook Little, Scientific Director Dr. Robert C. Hcckett, Associate Scientific Director W. T. Hoyt, Executive Secretary 1. Mr. Hartnett opened the meeting by welcoming Mr. William J. Halley of the P. Lorillard Company to the Committee. He lauded the Scientific Advisory Board for their excellent work and dedication in guiding the program of research for the Tobacco Industry Re- search Committee. The Chairman described the fellowship program and the desirability of continuing it in view of the many compliments and expressions of apprecia- tion which have been reflected from deans of colleges receiving the fellow- ships, and others in the scientific world. The goodwill engendered by the program has proven to be invaluable. He explained that he intended to follow the same procedure as in the last two meetings, and thereupon requested Dr. Little to make his report as Scientific Director. , C T R 6241 CONFIDENTIALr MINNESOTA _ ~4 4 r,,,,4 TOBACCO LITIGATION C ~ , ~M1 ~"'~~'~~ ~~ ~~ ~~ ~ ~~ ~p

I "'.J ---,U1,1L11) aub1ECi 10 AUG. 20, 1985 NON•DISSEMINATION ORDE~ - IN ROGERS AND DUKE CASES. 2. Attachment F"V1 covers Dr. Little's report. Dr. Hockett supplemented Dr. Little's report with a description of the status of research in procress and an analysis in lay terms of the categories being pursued and the initial indications of what might be expected from wc k in progress. 3_. ASr. Hartnett discussed the proposed budget for 1956 as indicated on Attachment r2, and explained that it carried the recommendation of the Executive Committee. He described the cash forecast for the Corr.nittee (Attachment ""3), and explained the cccp:exity of matching contributions on a quarterly basis against grants, grant renewals and current costs. The Chairman further described the fact that contributions, to date, have lagged behind actual budget approvals, and that it will be necessary to call for the fourth quarter installment for 1955 in December of this year; and that a notice for the first quarteriy installment in 1956 will be sent to members in January 1956, as soon as assessments are determined following the issuance of the :;ootten estimates of cigarette production. The budget of 5994,0C0 was unanimously approved by the Coconittee. 4. The Committee was advised that research grants, to date, have been made in the amount of Sa11,E:2.60 by the Scientific Advisory Board, of which amour.t 5464,341.4C had previously been formally approved by the TIRC. The new figure of 5811,E12.60 was presented and unanimously approved by the Committee. 5. Mr. Hartnett exnlained that Ltr. Herbert A. Kent, Treasurer of the Cor.~ittee, had retired and that he had asked 1.'r. -william Halley to serve as Treasurer. Mr. Halley was appointed Treasurer by unanimous vote. 6. The Executive Secretary presented an administrative report (Attachment #4). 7, Mr. Darrow of Hill and Knowlton, Inc., discussed the subject of public relations essentially as covered in Attachment #5. It was the concensus of those present that the policy relating to infor- mational aspects of the program was very sound and should be maintained. 8. January 17, 1956, was selected as the next meeting for the TIRC. C T R 624? enclosures (5) CONFIDEt1T1AL: MINNESOTA ~"°• ~= ~ }.~¢'~.d; ~ TOBACCO LITlGATlO (vr t t! 'g ~r4 S ~-N

TosfLcco IN-DVSTRT Rss"ttCa CoWurrIa: THIS DOCUMLtiI ZuoJLui iu huu. cu, 1985 NON•DISSEMINATION ORDER IN ROGERS AND UKE CASES. ATTAC.Li'^--;'?' A1 STATE~.''~T BY =- SCIMTIFIC D=TOR TIRC Meeting - November 3, 1955 The present stage of development of the work of the Scientific Adviaory Board is roughly as follows. In research on cancer a considerable aumber of grants have been given in the expectation, in most cases, that considerable tire vill have t:, be spent before definitive results are obtained. In these slover experi- me..nts, progress report are naturally incomplete but vill become progressive'_y sigziificant. In this field alao, sone renevals have aL aady been aprroved. In the standardization of preparation of tobacco derivatives real progress has been made in defining the limits of experimental proced,.r e between which significant similarity to hu-an smoking is obtained. Sources of smoking e:achines and of smoke condensate for experi=ental work have been established and announced to grantees. In the field of car3iovascti:lar research, nost of the grants vhic': have been rsde involve what night be called the studf of relatively reYid effects of tobacco derivatives. There vill undoubtedly be fu±`..he_^ researca vork to be planned and supported in longer ter:m studies. The Board is thus finding itself in a position where "rid.ing range" on projects already undervay is becoming increasingly i_-perta".t, and the nu=ber of applications approved for new grants is d1r_iaishing fairly rapidly. Guidance of Research Dr. Eockett and various members of the Board have been busy visitir.g actual and prospective grantees to deter-n.ine the propriety of support a.rd the extent to which it should be given. This type of persor.al coverage is valuable both to the .e.AB as the recomending agency, and to the applicant or recipient. It engenders a close, personal relationship, builds confidence and forms the basis for more accurate judgaent of personalities than would othe-^vise be possible. In addition to personal visits, the plan of infor:mal conferences initiated about a year ago by the Board in the case of twelve cooperating pathologists has been successfully continued and extended., The.re has been a second conference of the pathology group and a third Is planned for November 20th. ~ CTR f24 3 C0NFIDENTIAL: MINNESOTA ~ TOBACCO UTIGATION f • "f ' R NU-4 00,31--n ~"~

THIS DOCUMENT SUBJECT TO AUG. 20, 1985 NON•DISSEMINATION ORDER IN ROGERS AND DUKE CASES. Att. . 2 Smoking Nacr.ines A first conference of those interested in designing and using snoking sachines was held at Ftaleigh, N. C., and vaa vell attended. According to the general opinion it was highly successful and vill, in all probability, be followed by other conferences of the saae group at later dates. Tissue Culture There is also conteaplsted for January 14, 1956, a conference on tissue culture. Scientists at the National Cancer Ir.stit;:te have recently published on the discovery of a synthetic culture nedi,.: for the primitive ra-alian cells known as fibroblasts (mouse, chick, rsn). This opens the road to a such more accurate qualitative and quantitative control of nutrition of r.=11an cells than has hitherto been possible in tissue culture. Other laboratories are on the verge of similar types of discove.ry which vill undoubtedly provide a choice of several synthetic culture aedia. The Board has, since its first meetings, been interested in the development of tissue culture as one of the key techniques in study_ng natural or induced changes in the an4r•i cell. It now feels that the time is ripe for a conference at the earliest practical moment. Such a conference should block out the type o: research progran which the SAB should support a:.d/or initiate in this field. Ca_'diovasculex Reseer ch There is also planned a conference on the possible card;o- .ascula- effects of tobacco derivatives. The plans for this are not yet definite, but it vi11 probably follow the conference on tissue culture as soon as practical. "'lhgaed" Tobacco Investigation of the sources of and needs for "tagged" tobacco indicates that this problem really divides itself into two parts: first, the actual growing of the tobacco in sufficient quantity to meet experimental needs; second, the auch more difficult and costly process of preparing this tobacco so that it can be smoked and its derivatives atudied. The first of these two steps is being organized vith Dr. Jacobson acting as chairman of this effort. A conference either before the first stage of the problem is organized, or between the first and second stages, will undoubted.ly prove fruiti%l and cors tructive. CTR 6244 CONFJDENTIAL: MINNESOTA TOBACCO LITIGATION C-1~ f;,M1 r# t`; 0~'~ ___i62_3CJ

19$5 NON•DISSEMINATION ORDER IN ROGERS AND DUKE CASES. Att. ,1 Tcbacco Derivatives After a careful study of the problem of obtaining and analyzing tobacco derivatives, Professor HaaEen-Smit of California Irstitute of Technology, on inv:•„ation, presented his views to the SA3 in some detail. He feels that the chem.ical fractionation ard analysis necessary to identification of tobacco derivatives are entirely practicel. 8e also feels, however, that the methods of bio-assay with which to test the physiological effects of such derivatives a..re not sufficiently defined or, in some cases, suSficiently developed. It would appee..r, therefore, that after prelimina_-y study of bio-assay r.ethods by the SAB it may be desirable to hold an In+•orr.al conference with a nu.:be_- of outside scientists, as well as with those within the industry, to discuss these problems hir'..her and to determine a program for research. Conference Policy It vill thus be obvious to the TZRC that the SA3 is givir.g a good deal of favor able consideration to the in_*or~^.sl conference as a ritally i=portant and largely new method of obtaining advice, criticisa and possible suggestions as to cooperation. It should be re=e.::oered tha;t such conferences a.re quite different from the for~.sl aeetings with prearrar.ged Frograss of papers such as those held by the ACS and other organizations. The degree of :re :'s discussion, and the opportunity for cross-questioning are both vastly greater in the inforsal type of neeting which the TIRC is sponsoring. Studies of Persorslity and of S=okir.r3 F.abits The TIRC is supporting several interesting studies in this field. The problem presented is obviously complex, and there exists very little precedent for its aaalysis and organization. For th:s reason the projects which the TIRC is supporting are individually dlfferent in concept ar3 extent, but are characterized by possible coeaon application tovard the anaver to the main question, "Lbes the heavy smaker differ as a personality from the light scoker or non-ssoker?" As mentioned in a previous report, the establishment of the fact that different types of people as-,~ included in different categories of smokers would open to the -,uiolic, as vcll as to scientists, the conceft that habits, including smoking, ; acticed by individuals are products of the-biological and physiological nature of the individual. As such, they a.-e reflections of different survival or disease potentialities rather than causes of them. Should such a point of view be demonstrated to be correct, an entirely different es^,.hasis would be placed on conclusions to be drawn from statistical association studies. C T R 6`4; - CONFIDENTIAL: MINNESOTA TOBACCO LITIGATION C ~~ R1,11 N H ~`~ 0ti 16, 4 0

1985 NON•DISSEMlNATION ORDER IN ROGERS AND DUKE CASES. Att. 1 - k - . In each of the projects nov being supported or organized, the plan has been, as a first step, to utilize data that have already been collected in connection with other studies, often at very heavy cost, vhere information pertinent to our interest may be likely extracted by a relatively inexpensive reanalysis. The Beard is being significantly assisted in organizing and following up these studies by having available the services of Miss Mary Burke who can act as a coordinator and critic of their various phases. lellovships I should like to rec- end the continuation and consideraticn of the possible ex~^,.ansion of the policy of giving fellovshiYs for resenrc!~ to students of Class A medical schools. The complete freedom of selection of these students on the part of the dean of the school, and the complete responsicility fcr c::oice of a research problem also lefr in the hands of the institution without suggestion or interference froW the Scientific Advisory r,card, a_e excellent indicatioas of the honesty of motives and broad interest in acienti''ic pr og; ess which those of us on the Board know have motivatecl a:-.d activated the TIRC. It is not within the Director's province to decide the public relations value of these fellowships, but he does wish to endorse corrlete?y and without reservation their scientific and educational value, and to s;,a:.e his belief that they ar e one of the very i=portant and corst:-uctive things that the TIRC is accomplishing. Public Relations While the field of public relations is not the major function of the Board, the attack on cigarette smoking initiated by some elements of the American Cancer Society and other groups makes it necessary for the Board to take proper precautions to avoid unjust criticism and to protect itsel.f against unfair or inaccurate statements of its motives or prog: ar. It is a happy and universal fact that the Board has been a coxplete unit in its thinking and has'not felt worry or strain concerning its ovn position or integrity. In this attitude it has been encouraged and upheld by the same sort of mature poise and honest effort shown by the TIFtC. successfully than was anticipated. In the las t report, the belief was expr essed that the Boar d's attitude of refUsing to be led into controversy or official scientific pronouncements vas sound and that it would pay increasing dlvidends in the form of public understanding and support- of the TIFtC program. The S1.3 feels that this hope is beinr'ful..'illed, perhaps even more rapidly and C I R f2 .1 r ,CONFIDENTIAL• MINNESOTA ~ TDBACCO LITIGATION 0 0 1 36 4 .1

1985 NON•DISSEMINATION ORDER 1N DGERS AND QUK_E CASES. Att. The nature of press and editorial coc:nent has very definitely become more judicious and balanced, and less heated and partisan. Various scientists of high reputation have individually taken issue vith the data or interpretations of the original attacks. They have not been sti_^ulated or inspired by the Board either as a body or as individuals. Certa,:n of these scientists have, however, recognized the fairness of the SAB and have submitted to one or more members of the Boa_^d either thei.r plans for publication or the actua.l r.anuscript. In the meantime, scae people in the American Cancer Society have shown signs of recognizing that its position was becoming increasi^:'f veaker, and that it had gone farther than the extent and type of data v:~1 adequately Justify. It is obviously very =ch better to have this real=za- tion come from activity by individuals and agents other than the TIRC. There are still some groups that do not trust the motives or fairness of the TLRC ard the SAB. It is, however, becoming easier to ask such critics for data on which their attitude is based. Each month that passes, each grant that is rade, and each report, of progress that is received adds to the volume of the data that support the fair and impersonal attitudes of the TIRC and SAB, and the.reby make it harder to support a positicn that misinte.-prets their motives. There exist channels of courteous and regular co=munication between the Board ar.d the research people at the Anerican Cancer Society. To this result Dr. Hockett has largely and successfully contributed. I^ the saWe way, he has develo--zed the already friendly and cooperative att..:::.e of the American Heart Association by frequent contacts with its Scient:::c Director. The matter of pLblic relations should not be dismissed without e.nthusiastic ackaowledgerent of the coope-rative and constructive attitude of the members of the fir= of Bill an3 Knowlton who have been assigned to duty vi`..h the TIRC. The easy and natural villingress with which these isdividuals have studied, absorbed and utilized the scientific point of triew is outstanding and re•:ai:s an important factor in the incr easin.g strength of our position. Ind-istry Opportunities The Tobacco Che;tsts Conference, recognizing the iaportance of nore adequate publication of tobacco chemistry, is sponsoring and developing a journal outlet for research contributions in this field. :'::s should increase the prestige of the various industry chemists who have, in the past, too largely hidden their light under a bushel. One of the needed e:forts of the i=ediate future is the study of ways and means to allow and to insure the pooling of purely technical dat.a on smoking and smoke derivatives from the laboratories of CTR f;`?1 -7 .CONFIDENTU L: Id:NNESOTA \ TOBACCO LiTIGAT(ON ~'.' C1"h F'IN 00364

IHIS DOCUMtNf SUaJu,1 IU AUG. 2U, 1985 NON•DISSEMINATION ORDER IN ROGERS AND DUKE CASES. Tor action at the first zretinr of TI?:C in 1?S6 Page 6 of Dr. Littl.'s Statessat to th. ZZ4C atrtiaa on ; oywsber 3, 1955, n+titled Attacb>osat fJl, has been ehanCed, for the r.cord, trf d:leting tba last senteae* of th.-first paragraph oa pagt 6 vhich reid.s as folloYS: "/ny barritr vhicn prrnats tht full tttilizatioa of their abilities by pooling techaical kmovlsd.gs should be b roYJea or dis s olved ." Also d,alst• th+t foll.ovina Da.ragraph vhicD reada t "Sha Eoard bopes that the TLRC vill coactrr in this riev and vill give St the benefit of that group's tsdgae.ct as to vays aad asans in vliic.h tbe desired rrsulta, tsq be accoQplished.' Sb. abore dalttions vsr: forna].17 acred bT tb+. TZtC on p.bru,ar7 lk, 1q56. C T R F2,~ CONF/DENTIAL: 1y1 NNESOTA TOBACCO LIT/GATION C6 - ~~ ~~'ti

4965 MUN-DISSEMINATION ORDER MI~,ERS A11D DUKE CASES. Att. 1 •6- the various tobacco companies. It has becowe very clear to the SAB that the various company scientists and technicians are exceptionally well- trained and creative investigators. Ua_EF-n ~.~ ~ .»~ . ~...------ -•--- a---- - ~--~- . ~ ti We are in a period wha e continuing creative planning based on new experimental techniques, as they become avail.able, will be an important function of the Boa.rd. It is also vise to reeW*phasize the fact that the basic nat•.::e of our problem is one which requires patience and continued contacts. Stud_ving the reactions of living organisms is always a cosplex and difficult matter. The response of the organism, whether it is a laboratory animal or a r.an, is varied a.nd l:able to change. It, therefore, follows that the rate of speed is slower and the degree of deSiniteness with which questions can be asvered is inferior than when one is dealing with manufactured products or inaniaate units. The TIRC has constantly shown an ap-,reciation of these unavoidable difficulties. No greater contribution could be - or carn be - made to the cor.tinued satisfaction arLd encourage=ent of the SAB. It has been easy and happy to vork'in a relaxed tra=e of mind which is based on the wide vision and long-ti_e point of v+ev of a.n industry as expressed through the TIRC. CTR 6249 CONFIDENTIAL: MINNESOTA TOBACCO LITIGATION 0 3 344

THIS DOCUMENT SUBJECT TO AUG. 2D. 1585 NON-DISSEMINATION ORDER lN,ROG AND DUKE CASE& A2TACrY-v-7T W'2 \ Tobacco Ir.dustry Research Co=mittee 8u=a.ry - Promosed Budaet 1956 Vs. 8udget 1955 1955 Proposed et 1956 Scientiiic Advisory Board * 566,500• ~ 576,500. T.I.R.C. - Ad^ini.stration ~ 88,200. $ 82,440. General 82,400. 63,200. Industry Tech. Co=. 5,000. 2,000. Total 175,6oo• 147,600. Bil]l erd Knovltcn, Inc. Staff T+se =196, 825 • #+161, 900. out-of-Pocket Fxpense 32,575• 28,000• Fee 60,000. 60,000. Tota1 289,400. 249,900. Contiasencles 30,000. 20,000. GRATD TOTAL $1,061,500. ~994,Oco. CTR f2;iJ CONFIDENT(AL: MINNBSOTA TOBACCO LITIOATION M: -, ~` G~~R ~~~~ '.~~`~~~~~S