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TOSJCCa IN'DL:STRT RIBLJRCH COMXrrrr_L MIS DOCUMENT SUBJECT TO IIUC, 20, 2985 NON•DISSEMINATION ORDER J4 X&M MD UK C,AgES, CONFIDIIr:'IAL REPORT :VBACCO It.DUSTRY R::S=kRCF: CCA:uSTI'r.. b:E_=G APRII. 28, 1955 Attendance Timothy V. Eartnett, CLai.rr„a.n Paul H. Hahn E=ery M. Levis Albert Clay Herbert A. Kent Sa...uel C. Linton 0. Parker McCorBs Edward A. Darr William P. Schveitzer C. S. Stephano J. B. Eutson J. Whitney Peterson Freeyan J. Daniels John Vance Eevitt George W. Vhiteside Be..-t C. Goss Richard W. Da.^^ov Carl Thompson ,~~.C. # // E The A: erican Tobacco Company, Inc., Brocvn & Williamson Tobacco Co:-poration Burley Auction Warehouse Associatior. P. Lorillard Corpany, Inc. }Sarylsnd Tobacco Grovers Association Philip Morris, Ir.c. R. J. Reynolds Tobacco Co rany Pete_r J. Schveitzer, Inc. Step..ano Brothers, Inc. Tobacco Associates, Inc. United States Tobacco Co,.any Perkins, Daniels & Perkins Conboy, Eevitt, 0'Brien & Board-An Ctiadbourne, Parke, Llhites_de, wo:Lf- & Brophy Hill Qnd Knowlton, I_^.c. Dr. Clarence Cook Ltttle, Scientific Director Dr. Robert C. Eockett, Associate Scientific Director W. T. Eoyt, Executive Secretary 1. }r. Ha.~-tnett opened the meeting and offered a Resolution as follows regarding the death of Joseph F. hi:l*An, .;r., which vas unanimously approved: "WHLTtF.1S, in the passing of Joseph F. C•.alman, Jr., his colleagues have lost an unselfish friend and a fine gentleran; And WEERE'AS, the late Joseph F. C>>>=an, Jr. was a devoted and constructive force not only for all phases of the tobacco industry but for the business and social co=,:nity as a xhole; And 16M_FAS, be served this Co"ittee .*aithf1:11y and helpfully from the beginni^.g as one of its organizers aad officers; , cTR 6221 ~°• °~ ,4 ~~ .~ CONFIDENTIAL: MINNESOTA TOBACCO LITIGATIO ~r t tt "~ -+rN

T}!IS DOCUMENT SUBJECT TO AUG. 20, 1985 NON • DISSEMINATION ORDER IN ROGERS AND DUKE CASES, -2_ esolved that the Tobacco Industry e express its deepest and sincere synpathy, ,f this Resolution be sent to his family and ~ . tfr. William Sc2rveitzer of the Schweitzer Paper .ttendance at the aeeting as a nerber of the d his appreciation for the practical expression 'o^pany's confidence in the objectives of the TZ?~. d various contacts v.th key orgaaizations and been =aintainislg, and described briefly some of the .t he intends to give a talk at the June neeti:~g •ehouse Association, an d discussed co..in g everts .ate to tobacco use and health. ;ked for reports froa Doctor Little, tLr. Darrov o'y• :nti''ic Director, and speakinb for the SAB, i of the Cc.^ittee: :ed our progrer et a11 ti=s vith cev..cr, -,ity, puz-pcse:ulness, and have avoided ccntro- ss fron vhich it cor,Ld be deduced that ou- le uv or that ve vere not opensindedly ig up the M:, as a focal point of leader- •ch and infor~^•..ation, ve have at the sar.e tine :e the emotione?:sn v=ile facts on the subject l health vere being obtai.ned." ice of h.is talk is Attachment i1. u-y gave the ad^.iaistrative report vh.ich is id Knowlton, Inc., reported on public relations ;3• ras elected Treasurer to succeed Mr. Joseph F. :d. C1R E22 22 X ONFIDENTIAL: MINNESOTA TOBACCO LITIGATIOy ~~~ ~B I •j~

THIS DOCUMENT SUBJECT T0 AUG. 20, 1485 NON•DISSEMINATION ORDER IN ROGERS A':J D+' - _3- 7. 2fr. Har;,nett reported on. the finances of the Co-ittee as of Marca 31, 1955. A copy of the firsncial stater.ent is Attachzent +4. 8. Research grants in the a.:ount of $162,962 vere approved by the Co=mittee, briagi.ng total appropriatio•^.s for V•ants ap;,rove3 up to $464,341.40. Q. The suggestion was rsde that Lybrand, Ross Bros. & Montg=ery, vho have been auditi.^.g the Cc==ittee's books on a g~etuitous basis, be ressunerated for such work. 10. Mie next neetir.g of the :'1tC was scheduled for a Friday in July, the exact date to be decided upon later. encls. (i+) 1 CIR f223 CONFIDENTIAL: MINNESOTA t,.r 'I ' ~"'~e i tH 0 0 1,6•t ~ TOBACCO LITIGATION

Ton.cco 1xncsrrsr RESE.RCu Couomrrrrs ATTACw`•=": 11 THIS DOCUMENT SUBJECT TO AUG. 1985 NON•DISSEMINATION 0°^En IN RO;,E,c, :*MD DUKE CASES STATI~.1"T BY T.E'r-.' SCIM1TZ'IC DT..RECTU?t TIRC Meetirr, - April 28, 1955 DEVIIAP.`~'J..'` +' OF RESEARCH PROGRAM 1. Patholoaical Studies Dr. Reirann has been In close contact with the various labora- tories selected for the cooperative pathological studies, and vith the individuals in charge of them. The problems of procedure in collectiorn of specimers of tissue for alcroscopic study and for standardizing the analysis of this aaterial have been cereful'_y considered. 'A plen to insure the =&x=z of efficiency in these processes has been adopted. Dr. Reisr.r.n pl•ans to hold a meeting of the g:-sWtees before the May meeting of the Scientific Advisory Board. It is robable that those ltboratories which had been alread,jr engaged in studies somevhat similar to the cocperative effort vill be contributing the !':.wst significant data v::hin a.°tter of a fev r.onths. :ris is, of course, a c-,.?ative sta!y vrich v:ll build up graduaLy, but by Ja.^.ua.-y, 1955, a cor.siderable r.e.ss of i.ti''o=...ation sLcL.ld be available. 2. Tissue Culture Dr. Jacobson and the Director a--e interested in the development of work in this field. The Dire=:cr has corresponded with Dr. Pcnerat (Texas ), Dr. C,ey (Johns Hopkins ) a;d y. Earle (2:ational Cancer Institu te ), who, with Dr. Charity I:ayr..outh (,;_c;son Iaboratory) vo-,:1d represent the leadSng workers in independent instititions. Each of these workers has given the opinion th3t lt shculd be entirely possible to develop ne•,:ncds of growing, observi:.g, and experi_.en`.inc vith hj=a.n and ot::a^ -a-.lian lung tissue In cultures. The Director p'_Lr.3 to consult further wit.h these indi- vidti:als either sinflly or 1^ a gro,ap to determine, if pessicle, where and h:_ suppler.enta,.ry finr.ncial aid and personnel can be provided for research in this specific field. Most ,)f the tissue culture vork has nst:u-alli des:t with relatively primitive types c' cells .hich ra,atiply rar:d:y and are easy to culture. Lung tissue, hovever, 1,ses technical probl_s. Since the organization of the Scientific :.3ti=sory Board and its echasis on the need of such experimental work with 1•s.g tissue there has been increased interest. It seers that it should be entirely practical in the near futi..-e to sta_ t vork on this pr oble.lr. CT? 6 22) 4 .C'ox[~n:•rJliq[: i~.[h'n[;surf. _ # ~ ~ OFR C'C'O LITIGA1IUN Cr f " R f l N 31 In

InIJ UuLuMLhl JUDJ[L1 lu AUb. (U, 1585 NON•DISSEMfNATION ORDER IN ROGERS AND DUKE CASES• .-2- 3. Consolidation and Standard:zation of r:ethcds and Yzterials A. Animals - The Tobacco Industry Research Coczaittee has given a basic grant to the Jackson Laboratory to insure, insofar as possible, •!:e availability of genetically controlled z::,uae :ater ial for the vario•_s - grantees under the Tobacco Industry Research Coscittee. The Iaboratory is providing quarters for certain of these a:,'wals in an isolatei hv.:si.-•g •=r•+, and hopes to obtain further resources to add more of such units in vh:ch, y eventually, others of the fo••mdation stocks will be housed. It is interesting to note that Dr. Wynder on repeating his akin painting experi- ments with certain genetic stocks not originally used by him has obtained different results from those which be initially ar.nounced. This is an example of the absolutely essential factor of biologic variabilitl, without proper consideration of which repeatability aarl significance of results cannot be evaluated. B. Tars - After ca.refuly study, the sub-co=i ttee charged wi th the p:oblem of standax_ization, reco=ended that the Ecusta Paper Corp. be approved as the first standard source for tar preparat=ons. Efforts to standardize further the processes of preparation and storage of tar will :e continued, but it is the belief of the Scientific Advisory Board that significant progress in accuracy of research will result ^^cn L.edlately establishing and util:zin3 controlle+ conditions of production azi storage, even before pe.rfection is at'•.ai.ned. Word of this action has been sent to grantees under the Tobacco Industry Resee_ ch Cc.--ittee, a.ad also will be given to others engaged in research which lies in sir.il.ar or related fielas. C. Smeking Nschines - Here again, a careful study has been a8ae and standa..-d types of racnines have been reccmmended on infcz•mation which shows that they s:r,alate most closely conditions of hu..,an sroking hab:ts, and can be controlled and manipulated with the highest available degree of accuracy. Ir.fcr~~tion concerning this action wi11 also be distributed to the same class of investigators receiving word of our action on ta.r. It is interesting to note that some months ago, on the occasion of ar.nour.cement by the Scientific Advisory Bcard that it would concern itself with standardization in these fields, scepticism and sarcasm were expressed by certain individuals engaged in me3ical studies on tobacco effects. Altnough, as above stated, much needs to be done to perfect the mechanics of the processes under consideration, progress of a significant nature has actually been made by clearly defined recorendstions which are beginning to bring order out of the chaof which previcusly existed. h. Supply of C.L It ha- beccme evident to the Scientific Advisory Board that the demand for radioactive carbon will be extensive and continuing. Dr. Jacobson is head of the sub-coaittee vhich is engaged in studying available sources of tobacco gr ovn in an atWosphere of C1L, and in deterrining the probable extent of the future demands for this material. The existing sources of supply have been contacted, ar.3 if the dea•and appears to Justi:y it, the recomrendation v111 be rade for exter.ding the facilities of these , CTR 6 22 ; CONFIDENTIAL: MINNES01'A ~, ~-.~ f.€ , y~ TOBACCO LITIGATIO ~,, ~4 ~' ~ ( ' ( ~, (N

THIS DOCUMENT SUBJECT T0 AUG. 20, 1985 NON-DISSEMINATION ORDER IN ROGERS AND DUKE CASES -3- institutions and/or for establishing new centers. :*i:e use of "tagged" carbon in the detailed analysis of tobacco derivatives is one of-the best prospects for future progress which should extend beyond the limits of knovledge available from other methods of analysis. 5. Coronary Disease Drs. Coimroe and Cattell have given continuing study to the organization and support of research in this field, and a number of grants in it have already been aade. Other applications are being studied and tL::-e is gradually being obtained infor--Ation of many kir.ds vhich will unda::ctedly be capable of correlation, and of being used as a basis for planning new an~ creative experiLentation. It is iszportayt to note that in this type of in.estigation there are and viL' be many opportiunities to make clinical studies as vell as to utilize anir.al material. In the fields of carcino- genesis buzan rsterial car.not, of course, be used experimentally but in the study of the effects on various physiological prccesses as affected by nicotine or by other tobacco derivatives, hura.-ss can and vill be utilized. It should be remembered that cardiovascular diseases have long been vith us and that they offer a hard and tough "nut" to crack. 6. Statistically Asse_bled PoLUlat:ons Dr. Eockett and Miss °_~i:ke, vith advice from Dr. Wilson's sub- • ec=ittee, are contacting various possible sources vhich L ig'r.t be used in collecting data in this field. :t would see= that two r.ajor possibilit{es have already sugges.ed ther3elves as follovs: a) The relationship of markedly diffe-e-.t physical types to physiology and cause of disease, a.nd incidentally to smoking habi:s. It is an interesting fact that in spite of continued studies by physical anthro- pologists, the description and classification of human physiological types is still elementary and far from satisfactcry. In general, however, it vould appear t:.nt the type of cla.ssification suggested by Sheld-)n is sutficiently clear to allow the asse=bly of data on his two exire^e physica'_ types. One of these, the "endomorph" is the relatively short, oti•ertieig'::t hyperactive and extrove-t type. The other, the "ectomorph", is the relatively tall, underveigbt, asocial, and ir:troverted type. With the belr of insurance coapanies and simaar large centers of inforration on physical types and cause of death, it sbculd be possible to ob'.nin some interestir.g data on the natural history and physiological be'svior of these two extrene varieties of humans vith which ve are all familiar. The Director would like to emphasize the fact that the training,ard availability of Dr. Rockett a.*.d Miss E;L ke fcr this Furpose gives the Tobacco Industry Resessch Co r--ittee a team of workers in direct and continuing contact with the problem. This fact is a_n essential element in justifying the opinion that such studies may prove to be extremely valuable. b) The general f ac tor of "stress" see.s to be rapidly presenting itself f~r consideration and study. In a general way it has long been recogr.ized as a possible factor in the etioloay or develop=ent of coronary disturb&nces. To sor.e degree, also, stress has been considered a possible contritu:,:ng factor in the orig:n and development of sto:.ac': ulcers. It is entirely logical to ask the question whether continued stress CTR f`'2C CONPIDENtfAL: MINNESOTA f.. •.t~ r= y;,,3l,;. f TOBACCO LITIOATfO N ~ ~-, ~ ~' ` ( ( !

7HIS DOCUMENT SUBJECT T0 AUG. 20, 1985 NON-DISSEMINATION ORDER IN ROGERS AND DUKE CASES. •1,- nay not also so upset the physiology of an individual that horWonal or other metabolic unbalance results. Should this be.the case, it would be entirely probable that certain individuals fail to correct such unbalance and that there vill be present in their bodies areas or systems less subject to control of function (including gro`rth) than is the case vith certain other individuals. It also seens entirely probable that individuals un.".er stress to vhich they are failing to adjust, vill use as outlets for expression of their frustraticn and "discorfort" excess in certain habits, such as s=ski:s, drinking, etc. Such excess would obviously not be the cause of their stress but vould be very closely correlated and associated vith it in any statis;.ica1 stu3y. To s:n up the situation, statiaticians state that 1•:ag cancer, and perhaps all types of cancer appear to be associated with excessive s=k~. Statisticiar.s also state that cardiovascular disease seems to be associa:ed vith excessive s: oecing. No one has, as far as Z kncv, published a^.y data on the possible association of cardiavascular disease and ca-ncer. .'1his might be difficult to prove, even if it existed, because either ailment alone is apt to kill the irdivitual. If one of them occurred in advance of detecticn of the other as a cause of death, little if any effort would be made to es•,zbi_sh the existence of the second one. I-. appears somewhat absurd, however, to believe that tobacco of al.l the materials used t•y ab: has the extrac: d:r.a.:--; and diversified pover of bringing about these two great categories of disease and causes of death, vhich have nothing in co- on, except the fact that they r.ay arise :rcm internal bicthe_-ical unbalance. If it can te established that such unbalance ccct:rs =r e Srequen;,ly Snder stress of vsrious types, the whole si tLa.ion can be more sirply defined, 'even =:c::.3.: the research to correct it vil: be long an3 arduous. It is perhaps interesting also to note that stress :Lnder ur:an conditions and in the life of males is apt to be at its highest level. These two categcries cf Individuals also shcv relatively a higher percentage of excessive sr.c'iin„ an,: of the types of disease nentioned. EDUt;ATION AND PUBLIC Ft''..A.?'?0NS DEVEAPt~'-'~4-TS 1. Scholarshins On recor=enda:ion of the S_ienti:ic Advisory B:ard, the :bbacco Industry Research Ccsmittee has established on an exper=ental basis one cr more achola.rships in leading medical schools throughout the country. Tais is a sound and constructive step in its own right as an encouragement to development of much needed future Investigators. It also has excellent public relations value, :n that it does not restrict the field in which the student works, thereby demonstrating the breadth of view of the Tobacco Industry Research,Co==ittee. By the award being r..a1le by the Dean or other officer of the school, it further shows that the Tobacco Industry Research Co==ittee does not vish to dictate or doair.a:e the choice of individuals, and that it has confidence in the school officials. It will be interesting to observe and study the develop=er.t of this plan, to vhich Dr. $ockett is giving considerable attention. C T R G227 CONFIDENTIAI,: MINNESOTA TOBACCO LITIOATION c C, 0

"' --""'Lnj 3uttltCl T0 AUG. 20, 1985 NON•DISSEMINATION ORDER IN RRS Ak~UKE CASES. 2. Srea_yi::c Act:%=t:es Dr. Rockett a.^..ad the Director ar e receiving and accepting an increasing number of invi`,.aticns to speak on the program of the Tobacco Industry Research Corsittee and its Scientific Advisory Board before aedical or scientific gro,-*ps. This activity which can also visely be extended to cerrain lay a o,:ps, is i_.portant in that it convinces the audience of the serio:sness of purpose and of the ispersor.al and acientific approach which Is being e=ployed. It would not seem advisable to extend by deliberate effort such activity at present, but its natural development under the initiative of organizations that ask for it is a healthy sign of increasing interest devoid of the unhappy over-erotior.al ez:phasis that existed earlier. 3. Public Affairs °s--ph, e t For the past several weeks, the editor of the Public Affairs parphlets, :~. Stewart, has been cooperating in a friendly and construct:ve way with representatives of the Tobacco Industry Research Ccaittee ar.a Scientific :.dvisory Bca.rd in revising for public=tion the text of a, on lung cancer. T:is p.^phllet was prepared 'cy ?at :`_-Grady, chief scier.ce writer of the A=ericer. Cancer Society. It has been radica' iy chsagea e.-:d i_-Froved as a result of these conferences, and when published, altho,:gz noz, ideal, was a distinct advance over any previous statement which *ad the stasp of the Anerican Cancer Society's approval. EiL' ar.d FC-.ovlton has been a very a est help in this whole nd,~tst~e:.t. 4. Relaticr.srirs vith the ?=erican Cancer Society A.s a direct res::1 t of Y_r. F.artnett's contact with M--. Adys of the American Cancer Society, relationships have ste_d!ly i=pr ove3 and have even reac}e'd a point where the IScecutive Cec: ittee of the American Cancer Society passed a resolut=on of co.^^e.^.dation concerning the acti;rities ar.d objective of the Tobacco Indistry Research Co=ittee. Along with tw's specific evidence there has been a steady accu:h,'_ntiorr of information w'nice in3icates a very defi=ite but dignified a.nd gradual official retreat on the pa.-t of tae Arericaa Cancer Society from its original extreze "cause and effect" attitude. The appointment of Dr. Ha..-ry Weaver, who conducted the Princeton corSe: e.^.ce, as the indivi_v.al in charge of all of the institutional grants-in-aid of `..he Acerican Car.cer Society would, I believe, be properly evaluated as an ir.dication of the accuracy of the previous statement. Opinions concerning the ability of Dr. Weaver may vary, but the fact rezaina the same that he is on record as having been to a large degree responsible for the L.clusion among the perso:u:el of the Princeton conference of indivIduals holding quite different points of view frcz those originally adopted by the Society. The appearance in the vritten material distributed by the American Car.cer Society, after the Princeton Conference, of an adder.aua which took a=ore positive stand in corSi .•tion of the "guilt" of tobacco than did the conference itself was a disturbing factor. The Director has , C T R F22S CONFIDENT/AL; MINNBSOTA TOBACCO LITIGATION ~` ~ ~ E ' T 0,

TOB.ACCO IN-DUSTRY RESLJRCII COmSQTTLx " -~UJLti Ju AUG. 20, 1985 NON • DISSEMINATION ORDER IN ROGERS AND DUKE CASES, AT;AC1~-='2 STAME •~'T BY Tr'ZZ t'-.XE.,"Li'ZYE SECiL':ARY T.MC Meeting - April 26, 1955 The TLtC is nov four months into its secor.d year of operation. Its present activities, eczrpared to those of a year ago, present sone sta,.-tling differences. There is no longer a scramble to'"org:nize staff work, to set up a scientific program, to determine policy and to gracefully har.dle incuiries, for we now have a businesslike operation where aatters such as sta.•f, policy, lir.es of action, ar.d even unusual proble^s can be faced quickly with ar-ini.bvm of con,hision. Thus, in t•;r ning from organizational activities, we are confronted with those which call for better coordiaeticn of activities ar.d a general tightening up of e':iciency of operation. We are still faced with a certain n•.:=ber of crank letters and correspondence of various types, notable anong which is a grovin5 nL•ber of reouests for in.`or-~..~ation on the subject cf tobacco and health. This co=es, apart froa press and in.'br-..Atlonal sources, fr= s:;:3ents who see.-- to deiie~t in choosing this topic for undergrad-iate work. It is notable in other correspondence to see a change in the tene of inccni-g letters. N'here previously they had dwelt to a large extent on criticism, now a tenor is evident of accepting the intent of the Cc^ittee, an: of expressing a desire to participate in the work of the Coa: ittee. Tnis is apart fr = those just seek+r.g funds. Since the first grants were made in Semte=ber 1954, a total of 25 gran=s have been made in the aoaunt of $464,3'-1.40. This includes the Pathologic-Anatomic Project involving ten hospitals, and the Fellowship Program with fifty students participatir.g. Aopiications come in regules ly vithout solicitation, but the feeling of the Board is that the solutiorn to our problem vill most probably come froz work we origir.ate rather than rav applications. Meetings of the SAB originally were scheduled for one day each month. During the planning and organizational period these required two days each month. Nov that the organizational and progra--ming stages have been completed, the Board meets for two days every other month. More aatters are being handled by sub-coaittees of the Board and less in full session, although all final decisions still rest upon action by the full 5%ti3. By the te.-= of the State=ent of Policy we are nov begirzing to obtain six month progress reports from our oldest grantees. Doctor Bockett is ptrscnally following up on these reports. You will be advised vhen and if findings prove to be i•mportant or it:eresting. , CTR 6229 CONPIDENTIAL: MINNESOTA TOBACCO LITIGATION C ' 0 ~'~ ~ 6 2 ~'~

~~~D EMe~ ~ AU6. 2p, NATION ORDER IK Ro~ERS A`!D DKE q2~ In recognition of the statistical phases of the TLRC pro6:am, Hiss Nary Burke ha.a been ecployed and is on the staff of the Coc=ittce, spending full time on the problems of statistics. She is available to consult and assist the institutions to which grants have been aade, and she is also available to analyze data attacking tobacco, as vell as to effect such statistical work as the SAB directs. A most interesting exar^ple of what statistics may be able to do for us has come out of the rathologic-Auatomic Project initiated by the SAB. Seven of the ten hospitals cooperating in this project have reported their total autopsies and total cases of lung cancer by years, covering the past five year period. This covers a total of 24,118 autopsies and 690 lsn6 cancers. We have found trst the percentage of lung cancers thus uncovered is not rising over the pas t five year period. When these statistics were reported to the Advisory Bcaz^d it was felt that they were very indicative, although not conclusive. Work, therefore, is now underway to study clinical adsission to hospitals for surgery in lung cancer cases to see if, perhaps, the supposedly rising trend has ceased to exist there also. You may rest assured we vill follow this carefully and keep you posted as soon as statistics and rationalizations therefrom are stable. In addition to coorr..'aating the activities of the SAB, the Technical Cor=ittee, grants. public rel.ations and others en6aged in vork relating to the Cctaittee, liaison is being maintained vith people and organizations whose acti•rities .:.ay in a.-ry way reflect Lp-zn tobacco use or the work of this Co--ittee in s:.idying its possible relatioLShip to hee?th. Here, the fact sNculd be expressed that the Com=ittee's vcr:-k is gaining acceptance in the medical vorld. We find aa.y more inst.ances of doctors spea;cir.g out and saying aa:ch more fact is needed before conclusions are drawn about tobacco use and health. We find more instances of doctors taking a forthright, vocal attitude on this subject rather than just sitting back and draving conclusions from the few attackers. It is gratifying to see the response to the fellowship t ants which have been made. 1-'hile one would naturally expect awards of this sort to be taken up itmediately, one would hardly aepect the many la-:da:orf statements which have been received from the instituticns ad;.inisterir.g the fellowships. We have not received any agplicatio:u for grants-in-aid from two institutions (Cornell Medical College and Yale University Medical School) for, as we •.:nderstand it, those instit.rtics have nct permitted investigators in their colleges to apply for grants. Eac3 has, however, now accepted fellowships, and it would seem ver1 difficult for them in the future to reiuse their doctors permission to apply for grants in view of that. The Fbcecutive Comittee h,as approved the removal of the ZZRC offices to the new Socory Yacuur Building early in 1950' in order that they shall be in the same building vith Bill e.nd Knowlton, Inc. The =C office will not, however, in any p:ysical way be connected with Bill and Knowlton but will have separate quarters, switchboard, etc. CTR f230 CONF(DENTIAL: MINNESOTA _ TOBACCO L1TlOATION C "'I'