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Council for Tobacco Research

the Research Program of the Scientific Advisory Board to the Council for Tobacco Research - U.S.A. [Informs the Purposes, Policies, and the Research Program of the Board]

Date: 28 Apr 1960 (est.)
Length: 9 pages
CTRMN003366-CTRMN003374
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MAR

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PAMPHLET
Depository Date
25 Sep 1995
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Ctrmn00000667-6967
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003
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118
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xnq30a00

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~ The Research Program of the SCIENTIFIC ADVISORY BOARD .'t}iE COUNCIL FCR TOS CCO RfSE.SRZN - U. S, A, TO E I ~:R- 13g2 CTR NH 003366
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SMPTLFTC ADVISORY BOARD to the Tobsxa Indnttty Rdtarch Camtnlttee KPNNFiTH KHRRIIS, LYNCS, Ld.D., Sc.D» LI..D., Chmfrman Praldau, D.mc of Foculry and Pr,olaiur o11•atlwlopy Liedical QoIkge of South Carolina Chatleston, South Carolina RICHARD 1. BING, M.D. lro/sssor of Medidns and Bsad of Departmcnt wayae Sate Untratity Colk:e of Medicine Detroit„ M;chtsan McKEEN cArtEu., ps.D., u.n. ProJcnw of Plarnerobty Cornen Uai.asity Medical Colk;e New Yorfr., N. Y. JUI TUS 8 COMROE, J:., M.D. Dbertor, Qr&o.asculu Research Iauiaate Uairesaitq of California Medical Center San Fraacisco, QaTifornia LEON O. JACOBSON. M.D. Projcsror of Mcdicine. University of Ghicago Dirntor, Ar=oane Caacer Rdearcb HoRiul C hicato, IIIiaois PAUL KOTW, M.D. .tnociws Prolessor of Pathology Uai.aritp of Sovtbc a(kkifornia. School of u~'~*TM Los Ansela, Califoraia CLARENCE COOK LII'IIE, Sc.D., ILD.. Lirr.D. Scicntijc Director, Tobacco Indusuy Research C'om+*+***» Dfnrtor F.nurinrs. Roacoe B. Jackson Memorial L.boratory Bar Harbor, Mame STANLEY P. REIMANN, M.D., Sc.D. Ssisnatjic Dirncto. Emninu, The Inrtircute for Caxet Research Dbtietor Enuritur. Tbe L.akeaau Hospital Research Imfaute Fhilade}Phia, penns7tvaaia WII.LIAM F. RIENHOFF, Js.., M.D. .trsoctere Prolessor of Sw-rtry John. Hopkins Unirasic7 School of Medicine B+ttiaocae. MuTL.nd EDWIN B. R'IISON, PtzD. I.L.D. . tmolsssor Ewncrtnu of Ytul Startrcicr Camb 'ndfie, Mana-hn.em ROBERT G HOCKETT, PB.D. Anociate Scientific Director THE RESEAR, Tbe Tobacco Indu 1954, to sponsor indepe: into the hands of a Scicr tiauim.g scpervisioa of a edncatau and scientists ac Advisory Board, tb. Vam. 'Ihis booklet is ir. "Ibe Committce's Board an ffiusn.tl, if nc widtst poaible rtnge of smder coad'itions of nta, Littk. Board Detetmr'ne, A Because of the b: $oard, scieatists wbose tespoctiv+e 5t]ds of 1-no4 sne yvta assarance of c Tbe Scientific Adv trxy ia.ettigatiotss u 2 ho+vever, thxt ladivic::a' other applicants, obtair RetaQcb Committa. T: 1343 .j , TR~ CTR' NN 0~'. 33G.0 :~
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kRD smictex i, chaIrmn :ine D. cnmiaet ibontory i xr. Rescarcb rcb Inscirute .D. f THE RESEARCH PROGRAM Tbe Tobaoco Indzstq Racarch Ccmmttfloe, iocmed in Jaauary. 1954, to :poc.or txkptadeat raearch iada tob.cco tre and bahh, Put 3ato the hanu d a Sdeati5c Ad:esory Board the de.riopmeat and ooa- . tiacmg supa.Wm d a research po8cy and pcvgram. Many doctors, odxatoa and aamticn want to know about the Committee, tbe Scica- tific Advisocy Board, the parpwes aad.pol'icea, and the ramutb pco- gram. '!hn bookbt is iateaded to aa:.ver tbae qoeatious. "Ibe Committee's approach has tivea the Scicatxfic Advisoiy Board an unusual, if not caiqnc, opportunity to faur and *gtade the widest posnble range d reaearrh by aatstznd'mg scientists and doctors aadcz oan~'irions d trimost lrsodom," scrnrcding to Dr. Clarrace Cook L.ittk. Board Dettrlitinel.lCtsQitset Bxause d the broad iesponslb~ d the Scicatdic Advisory Bou,d, sc3entim ..bae oompctt.nct b securr.2y atablished in tizeir respoctive 5dds d knowledge are WYed to aa'vo ae its membexs. They a7e givea suoraxe d complete .cieadfic freedom in tb= worY. The Scieati8c Adsury Board does not ooodnd sped5c labors- tiocy ta.octigatiom as a Board. Thii does not rnk out the pocabl~, bows.er, that }odividnal membas may seek and, ia coazpetitiw with other appbaats, obtaia research grants from the Tobacco Indnstry Reacarch Committoe. Ihis is a pobcy oammoa to otbcr sim'11ar bodia. I CI'R_ 1344 ~ ~ ~ ~ C T R 0 0'-.
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The Board membe2s retain oompktely their sssodations with their rrspective institutions and, except for the Scientific Diroctor, a:e rdm- burned only for time and expenses iavotved in their ae.rrices to the tesaarch prvgrim The Board determines the scope and dirccxion of the re.eairh pro- yam; revirw: and aoticits roque= for research :raats from aai.aritie:, hospitals and other r+ocognmod • reseuch ocg,mizetiom or - from iad- viduals there tituated. Regular aoeetings an held by the Board to carry out its achednkd .Pock. In addition, members of the Board froqueatty undertake tpxial assigameat: in ooanectiom with the bc.rbpmeat of the research prrogram. drznual Report The Scientific Director issves an Annual Report that dacribes the progress of the research program, lists grants and contains abetraets of papers poblished by scieatiit: who have acloaowledgfld support of their work, in wboie or in part, by the Tobacco Industry Rtaezrch Committee Scope af Inseresta Defined Bdorz uadertaking a hrgeieale program of raoocameod'mt pmts to finance rev-arch projects, the Scieatific Adviwry Board in 1954 laid the foundations oo .vhich a scries of reacitrh projects eould be devel- opecf and coordinated. First was the delineation of the acope of ktersst: within which iavestiguions should be spooaored. Socoad was the oetan- izstion of a program to assure that neceuary ia~on wYS cader- taken without mmriccasary duplication of ..oilr. Scope Cover. Three Main Areas The outline of iaterats sets oat three main aru: ot ia.ati,prtion: l. The physical and chemical coarpoeitioo of tobsxo, tobacco smoke and accompanying prodntts, such as dgarette PaPen and additives. 2. Tusue , in aaia they ai ezposu or con: themc OTga.ti5 3. Smokir Pbysica duratic data v.~ degree~ It is rccoF done here and seeks to avoid r the field of tob< been mcaaclusi• careful study a where new or b The Pro6ram In its seCc program intead, tions raised cor to further unde: probkms. The produce clinica' conclusions reg; human health. I CTR= 1345 C Iq11 ' VIN 00"^-3` ~69
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i tssociations with their tific Diroctor, are reim- h their setviccs to the tlm of the resuzch pro- tmna from am!~, &Lrions or from fadi- I ky the Board to cury f( aDe Board froqneatty kb ebe development of Voct that desca-ba the Q containi tbstracts of bd gcd tupport of their r R.esearcb committce: t rrcommcad'mg gra.nts my Board in 1954 laid pja-ts could be dcvel- f tbe scope of inter+ests Sccond was the orga.n- .cs^.:Paoa wu tmdcr- sus of ic.esugatioa: I of tobaooo, tobacao :b as ciguate paPer's 2. rLUne changes or physiological respoaus in huaians as well as in animals, in normal lde or under laboratory coodidons, whe.a they are subjected to variow typex, duration and intcntity of czporur~e to variocu tobaccos, tobacco tmokca and derivutives or constitamtx of these.. Tzuoeft of special intaat aro thae of the IDoath, taags, gicnd:, heart, Yucular t7stem and other agaas of subjoctt of .ariooi atea, .ex and 'ctraau. 3. Smoking and otha tobaooo habits, and the emoti4nal tnd physical makeup o( aaolera, in rda.tjoa to esublishment, duratim and iateagity of tobaxo nae. and coczelatioo of tbese data with mczsbolic, tlsndnlar and aavow types cndcr rariocu deg.croa of stras and charieag+e. It ii :+eoogsuaod that edective work hat bocn done and is being done bere md abcoad in these SeMi. The Scieatific Advisory Board •eeb to s.oid repeaziag ..ocY thst has produoed .cctgted resvhs, as in the field of tobacco or tobacco mtote oaapaition. Where rantct have beea iacaaclvsive, however, or wheso grps in knowledge exist, further careful study aad weD-pLanod research may be indicated, e7pociany where new or better techaiqua have btcame available. The Proaram In its second step, tbe Board developed a coordinated research prvgram intended not only to kryestigate futx with rrspoct to the qucs- tiam raiud ooaarniag tobacco use and health, but also to contribute to further understanding of cancer, heart disease and other public heslth ptabkmt. The ptugraru, in operi.DOn tince mid-1954, is inunded to produce diaical and eiper'rmeatal findings thst are necessary for valid coacleuioal reYudiag (possibk) :etarionships betwroen tobacco use and human health. - I Cj~. 1346 231%
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Research Projecss Research projects are encouraged in the foIlowing general subjects. Primary rapondbtlity for overall advice and informal guidance has been assigned to andy trovpc and snboommitt.as of the Board .vtth consultation from outside spec:ialiata. Iwhalatiow of SrwoJae: Carefully planned and regulated experiments with marnmah subjected to inhalation of tobacco tmoke -uader controlled oooditions. Di,vtt .(ppiioctiow of Snwke Cowdswaat.a: Projects to best the effect of amoke coodcasates, derived under controiled oookioom, on tissues of aaim.ah with varying degsees of tusoepti'bt'1:'ty to cancrr ot other allmeats. Study of LAcsg Tiunsa: Projecu to ttudy lung tiuuet in Ttviag aaimila and-man, and studies of putmonary pbysio}ogy in :ela.tion to smoking. Haitawm.t Ckange, tn Tiuues: Studi cs of malignant changes oi tiuaes under controlkd laboratory conditions. Study o/ Cardiooaacular Tiuueu: Studies of changes involving de- generation or imbalance in cardovucular tistaes, as well as re- spoases to nicotine or iahakd smoke. Bobita o.d Cl.arxtertatic, of Sanoksrs: Survcyc of selected populs- ooos ia various parts of the cotmtry to dctermine the chir&c=Ls- tics of human smokers and non-tmokexs, considering aM sex, emotipnal constitution or condition, environmental faaors and ezpocurrs, as well as smoking habits. Prtparation aad Bioaa.ay of Tobooeo Deri~: Development of wQrocs for a continuous supply of tobacco smoke ooodeasatca for use in biological experiments. Efforts to improve duplicatioo of haman smoking in machines, and to maintain a high degree of control of the eanditioas under which smoke is produeed, Tiua. C"lture: Ciltivati, of centtlar rapoases subcunccs. Yl.odla..o+u Sub ject.: F'lant pb76ology, aic to the ccacnl progra- Reaearch granu undc tists at such iastitutions a Uaivsuity ot Texas, the ' Zion Hospiul at San F. Fondham L}niver:ity, Harne tau at Buffalo, New Yor CoIkge Medical School, Surgery, the Ivitdiral coli ciana and Surgcons at Col New researcb applic-- Scientific Advuorv Boar: to time. ADMINIST The Scieatific Advis: research groups or orV.: Board also originates prc and seeks appropriate iL projects unda Tobacco 1 Each applicant and <uremant of policy apprc The stazement of p< atarch Committcc "desL- froodom and without dor to direct the administratii course or to control its r are properly erpcndev .o- are reported in accordp ^. ~ ~TR: 1347 CT .~ f~~~ ~~~ ~ ~':~' I
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ywing general subjects. adormal gnidaace has = of the Board with regulated ezptrimeats tobacco s:aoke tmder ojects to tat the effect trrotkd coaditioas, on uacptrb~liry to cancer issucs in tiving aaimals sio{ogy in rdasioa to ;ant changes of tissues changes involving de- tissaes, as •fe.ll as re- :ys of sdxud popula- crmine the e'urarteru- considcring age, sex, vw-mental fac~.ors and t, ra.: I)evelopmcn t of smoke condeasate.s for mprove duplication of itain a high degree of e is produced-- Tissue Culn.n: Cultivation of lung and other tissues in vitro for study of cellular responses to tobacco smoke ingredients and other substances. Xi.cailmn.ow Subj.ctar Gastrointestinal ettsdies, aeloctad topics in plant pbytiolM, aicotine metaboli:m and other subjects rslated to tbe ceatral proiram. Reaearch p aats under the approved program have yooe to aciea- tiSts at ar..b tesftudom u the Utuversity of Soathera Catifornia, the Uaivessitp o( Texas, the Tempb University School oi Pharmacy, Mt. Zion Hrotpital at San Fraocisco, the Medical CoIlege of Virginia, Fordham Univerrity, Harvard Uairtnity, Roswell ParY Memorial Insti- tute at Buffalo, New York Uairasity=Beilevne Medical Ceater, Tufts Coikge Medical School, UtsiverYity of Pcanrytvaaia Departmeat of SurYery, the Medical Coikge of South Caroiina, the College of Pbysi- eiaai and Surgeons at Cobambia Uaivesaity and others. New research appEcatiatss arc tmder oocsunt ooasideratian by the Scientific Adviaory Board, and new grants are announced from time to time. ADMINISTRATION OF GRANTS The Scientific Advisory Board welcomes proposals from qaalified research groups or orgaaizatiom for specific researrb projects. The Board also originatcs proposals which will eaatn'buu to the program and seeks appropriate ind'svidnah and tastvd¢tiom to carry out socb projects under Tobacco Industry Research Committce spoasorship. Each applicant and prospoctive rocipieat of a grant rticeives a statement of policy apprvved by the Scicatific Advisory Board. The statement oi pokicy derlarra that the Tobacco Industry Re- search Commimee "desires to hrn aamtiats wocY with tbe Q+catrst freedom and wit3ioat domiaadon ot any 33nd. It wi71 make no attempt to direct the admiaistnticxi ot ti,e projoct o00o started, to infiueaee its course or to oontroi its resulti other than to be assured that the fimds arz properjy expended for the purpoee:s of the grant and that all findings are reported in axordaaoo with the best adeatific ptactice " ' CTH.1348 C 301 ~'E''~
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Forms of Applioadion Standard applicxtioa forms are aent to tbose desiring to appty for arants from the Tobaxo Indcrtry Reaea:rb Committee. The applica- tioas are sabmittod to the Scicatffic D'uector and to each member ot the Scientific Advisory Board for atndy and oommtat. Wbea fodicabed., peaomal oammtmicitioas or YWU are made .vish the app5cant in order to clarify or expand his proposaL F.arb application is measured a;ainst such criteria as the fodbwing: 1. Is the psoposal rekvant to the aoope of the progsam? 2 Is it made by an in&vidual qualiftod to pcdaQm the work? 3. ~ill it oootnbate to lmowledge of the subject? 4. How does it rank in inporYance with other projects under way or under contideration? 5. Doea it promise results not already ccmtrmplated from otbcr raeircb projects? 6. Can it be of .atue as a eheck av iast wos~ atready being earried on? The Board d'ncusses and reviews aIl appliatioas in regular meet- ings and recommends grants for the approved apg&ationc. Grants are then made by the Tobacco Induttry Research Cocrmittee. Unless ocbavviu requested or agreed, ptymeats are made qnar- ter3y in advance to the iastiwtioa at which reaeirrb is eooducted_ Grants may be tnndtzre-d from aoe iardurtian to anotber, where tbere is a change in the afflli.ation of the principal 'm.estigitor, if permission is obtained. Gnntoes are roquestod to ftztnnb a:cpott d scti.ities ami- annaaIty. Tbese are to include both aooaaating for fuad~ and summary of aG.eatific findings with sufficient detail to permit tbe Board to estimate progrtiss. A complete report is ezpected by the Saeatilic Advisory Board at the oooclusion of a project. This fma] report may consist in part of manuscripts prepared for publia.tion. ERCHANGEc AND PUBLIC Rr'rth the consenc :eoommcad the escb a:. on different projcrs. ' to assist and expedite form of occasiona] ia` scimfistt for discussio Tbe Tobacco In c presentation of resea- modical and scientific soeieties. It has no o; ways of any or all finz When a journai c iags from a projec-., t to furnish a statemec wbject taatt~ of boi s abreast of plans for ; a grant-cn-aid. In.atigztors an Board two dozen rrpr aid support from the Infotmition de:i• public by the Com-* ; While no spe:ii oovering costs of L _ Tobacco Industry Re funds upon presenta: 1349 CT R, fi-1 N 0 03 3;7 11
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• , those desirimg to apply for Committx. The aQplica- 4rsd to each member of the tmmsa t. W ben iadiated, rith the applicant m order :h criteria ai the foibwwing: a of the prognml f to periorm the .vorkl bc aabjcct? a otber projects ander way • coatemplated from other xinst work atrcady being plications in regular meet- d applicatioas.. Grants an 1 Committee. payments an made quar- earcb is conducted. Grants another, .vhere there is a 'rstiguor, if permission is report of activities aemi- ig for funds and summary to permit the Board to rpected by the Scieatific xt. This imal report may ablirs.tion. J EXCHANGE OF INFORMATION AND PUBLICATION With the caoxat oc graatoes, the Sdeati5c Ad.isory Board may recommend the eschange of iaformation betweea urvactgatim wotiing on diffeneat projocts. The purpoae of tliis nxchange ot taformation is to assist and erpedibe work in psogcxa. Such e=changa may take the form oi ooaisiooal fcdormal ooafcrraces of grantem and selected tucst scientists for discussion of pa.rticular Wpica. The Tobacco Industry Reyearch Gammittee approves the initial pracatation o( research raaYts by the ia.e:>igatar only in aocepted medical and scientific joamals or before accepted medical *or satztific aocieoes, It hcs oo objection to diuemina~ to the public in these ways of any or aIl $aal cooctusiom of the iavesdptora. Wbca a journal or society sclbdnks the presentation of any find- iags from a project, the 5cieatific Advisory Board expects the grantee to furaiih a mLeaxat or an abstract coseamg the date and geaeral anbjoct taatter o( his preseatitioa. The Board apptxiatcs being kept abreast of plans for pabticatioa of any paper res9hing directly from a graat-ia-aid Invcstiguors are requestcd also to furnish to the Scientific Advisory Board two daaea reprints oi any paper pnbbsh.ed as a result of grant-in- aid support from the Tobaccv Industry Rtsearra Comaittce. Iniormation aerived from .emi-sancul or $nal reports wW be made pabric by the Commrttee only with the peimiasioa of the ia.estigator. Whiie no special fvads ate prtovidod to assut pablica.>YOa of rtsults covering costs of t'I '~n g, typesetting or other expenditures, the Tobaoco Industry Researcb Committx wM eoaaider reqnescs for sncb funds upon presentation of tbe manuscript to be pabYiahed. 1 CTR. 1350 N N 0 0'J -~'J '~~'r1:

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