Council for Tobacco Research
Application for Research Grant An Investigation of the Spectral and Chromatographic Characteristics of Aromatic Hydrocarbons. [Study on High Temperature Gas-Liquid Partition Chromatography]
Abstract
CNF
Fields
- Depository Date
- 25 Sep 1995
- Master ID
- Ctrmn00000667-6967
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- CTRMN004974-4975 Anti-Smoking Theories Not Based on Complete Scientific Knowledge [Scientific Investigation Into What the Real Effects Are From Tobacco Use]
- CTRMN004976-4977 Hartnett Comments on Statistical Study [Research Intensified in Past Year, No Proof That Smoking Causes Cancer]
- CTRMN004978-4980 Doctor's Survey Termed 'biased, 'says Hartnett [Questionnaire Would Give No Concrete Conclusions About Tobacco Causing Cancer]
- CTRMN004981-4982 Hartnett Alerts Burley Men to Challenge Tobacco Attacks [Doctors Are Expressing Their Doubts About Statements Already Made; Tobacco Effects]
- CTRMN004983-4984 Bright Belt Warehouse Men Told Facts Challenge Critics [Still Looking for Proof That Tobacco Causes Cancer]
- CTRMN004985-4986 Tobacco Spokesman Says Facts and Position Are Unchanged [Various Experiments with Animals Showed That Cancer Was Not the Outcome From Tobacco Smoke]
- CTRMN004987-4987 Hartnett Comments on Statistical Study [Methods Used for Cancer Research Still Do Not Give Enough Information]
- CTRMN004988-4990 British Tobacco Experiments Unable to Induce Cancers [Still No Connection, Tests Will Continue]
- CTRMN004991-4993 Tobacco Research Grants Now Over 838,000 Mark [Tobacco Research Is Getting More Support From Doctors, Scientists, and Educators]
- CTRMN004994-4996 Statement by Timothy V. Hartnett, Chairman Tobacco Industry Research Committee [Summary of the Past Years' Events in Tobacco Research]
- CTRMN004997-4999 Tobacco Research Fund Raised to 1,500,000 [Finding New Ways to Break Down Tobacco]
- CTRMN005000-5001 Tobacco Industry Group Renews Medical Research Fellowships [More Medical Students Are Receiving Fellowships Than Last Year]
- CTRMN005002-5003 Hartnett Statement on Cancer Meeting Reports [There Is Still Much Research to Be Done Before Tobacco Is Linked to Cancer]
- CTRMN005004-5005 [Pathologists From Around the Country Have Studied Human Lung Tissues Over the Past Year]
- CTRMN005006-5006 [Smoking Patterns Do Not Explain Differences in Lung Cancer]
- CTRMN005007-5008 Hartnett Cites British Tobacco Tests Failing to Produce Animal Cancer [the Search for Cancer Must Be Broadened and Intensified]
- CTRMN005009-5010 Hartnett Comments on Statistical Claims [Although Many Believe Smoking Causes Cancer, Scientists Still Have Not Found Any Prof]
- CTRMN005011-5011 [Present Knowledge Doesn't Hint A Relationship Between Smoking and Heart Problems]
- CTRMN005012-5016 Hartnett Comments on Cancer Society Booklet [Pamphlet Omits Some Important Research Results]
- CTRMN005017-5018 Statement by Timothy V. Hartnett, Chairman Tobacco Industry Research Committee [Research Committee Needs More Scientific Investigation]
- CTRMN005019-5025 Tobacco Research Funds Reach 2.2 Million Mark [Over 60 Independent Scientists Throughout the Country Are Working in Institutions to Further the Research of Cancer and Tobacco Use, They Are Listed]
- CTRMN005026-5027 Hartnett Comments on French Report [French Are Reporting Rapid Cancer Formation in Mice, Hartnett Feels It Can't Be Judged on the Basis of New Reports Without Longer Consideration and Careful Analysis]
- CTRMN005028-5030 Harnett Cites Points for Clarification in Tobacco Health Study [Smoking Study Reached the Public's Attention Before It Was Reviewed and Before the Facts Were Made Crystal Clear]
- CTRMN005031-5032 Hartnett Comments on Wynder News Stories [News Story Claims That Assumptions Have Been Made About Mouse Skin Painting Experiments]
- CTRMN005033-5037 Statement on Smoking and Health Studies [Scientists Are Developing A Program for Different Phases of Tobacco Use and Health, Members Listed]
- CTRMN005038-5045 Hartnett Says Statistics Do Not Establish Causes [Studies Are Open to Assumptions and Certain Selection of Subjects]
- CTRMN005046-5048 Hartnett Cites Scientists Doubting Smoking-Cancer Theory [the Surgeon General Believes the Studies Are Missing Essential Facts That Should Be Acknowledged]
- CTRMN005049-5050 Scientist Comments on Benzpyrene Report [Benzpyrane in Tobacco Smoke, Under Investigation for Years Caused Cancer in Lab Animals But Not Humans]
- CTRMN005051-5055 "Cancer Researcher Challenges "Cause and Effect" Charges Against Smoking" [It's Difficult to Have A Cause and Effect Relationship When Dealing with Cancer and Tobacco Use]
- CTRMN005056-5056 [Atlantic Monthly Gives A Misleading Picture of Dr. Little and His Public Position]
- CTRMN005057-5058 Tobacco Committee Chairman Comments on Cancer Society Talk [Many Unresolved Questions About Tobacco Causing Cancer Don't Stop Researching]
- CTRMN005059-5061 Tobacco Research Scientist Discusses Smoking Question [Most Tend to Believe the Anti-Cigarette Theory But It Shouldn't Be Confused with the Facts There's Still Not Enough Facts to Prove That Smoking Causes Cancer]
- CTRMN005062-5062 Hartnett Says Leaflet Admits Differing Opinions on Smoking [Leaflet Tells How Scientists Disagree on Evidence]
- CTRMN005063-5066 Research Program Throws Doubts on Smoking Charges [Incorrect Claims and Harmful Effects From Tobacco]
- CTRMN005067-5069 Statement by Timothy V. Hartnett, Chairman Tobacco Industry Research Committee [More and More Scientists Had Doubts and Disbeliefs in the Charges Against Smoking As A Cause of Cancer]
- CTRMN005070-5071 Tobacco Research Scientist Discusses Smoking Question [Scientists Say Smoking Has Been Proved Guilty When Linked with Human Health Problems]
- CTRMN005072-5072 Pamphlet Merely Review, Dr. Little Says [Opinions Is All the Author Gives in His Pamphlet Scientists Are Still Disputing]
- CTRMN005073-5076 TIRC Fund for Research Boosted to $2,700,000 [Grants for Independent Scientists Interested in Studying Problems of Cancer and Heart Disease When Related to Smoking]
- CTRMN005077-5080 [New Knowledge on Smoking and Health Questions]
- CTRMN005081-5081 [Veterans Study of Smoking Habits]
- CTRMN005082-5082 [Report on How There Was Existing Research Evidence and How It Was Ignored]
- CTRMN005083-5085 [Regarding Anti-Tobacco Movement]
- CTRMN005086-5086 [Benzpyrene in Cigarette Smoke]
- CTRMN005087-5088 [Experimental Evidence Is Weak]
- CTRMN005089-5089 Hartnett Says Article on Arsenic Goes Beyond Facts [Farmers Use of Insecticides with Arsenicals on Growing Tobacco Has Steadily Been Declining]
- CTRMN005090-5091 [Scientists Who Produce Conflicting Results Are Being Ignored by the Health Department]
- CTRMN005092-5094 Statement by Timothy V. Hartnett, Chairman Tobacco Industry Research Committee [Even More Grants Have Been Made Available More Factors Have Been Associated with Lung Cancer]
- CTRMN005095-5100 Tobacco Industry Group Announces Research Grants [Grant Increases to $3,200,000 List of Grants Announced]
- CTRMN005101-5103 Tobacco-Health Research Described in 1958 Report [the Report Talked About Experiments That Were Unable to Produce Cancer and the Cause and Effect Theory]
- CTRMN005104-5104 [Report Shows That Other Factors Besides Smoking Have Been Causing Lung Cancer, But Scientists Do Not Dismiss the Fact That Lung Cancer Is Possibility From Smoking]
- CTRMN005105-5105 [Anti-Smoking Campaign Is Thought to Be A One-Sided Propaganda Effort]
- CTRMN005106-5106 [Questions Arise From on-Sided Study]
- CTRMN005107-5111 Cancer Scientist's Comments on Smoking-Lung Cancer Review [Evidence on Smoking and Lung Cancer Is Accumulating, Among Other Contributing Factors]
- CTRMN005112-5117 [Comments Relating to Observation on Various Studies]
- CTRMN005118-5122 Research Grants Announced by Tobacco Industry Group [$500,000 Was Added to Research Funds, A List of Recipients with the New Grants Is Mentioned]
- CTRMN005123-5127 Research Supported by Tobacco Committee Discussed in Scientific Director's Report [It Seems That Finding An Answer to Lung Cancer and Cardiovascular Diseases Are Too Complicated]
- CTRMN005128-5128 [Attacks on Tobacco, the Lung Cancer Issue Is Still Not Settled]
- CTRMN005129-5129 Nta Stand on Smoking Repeats Opinions [Statement Gives No Evidence and Is Dealing Mainly with Opinions]
- CTRMN005130-5132 Tobacco Research Group Adds New Scientific Associate [New Scientific Director Was Added to the TIRC, Curriculum of J. Morrison Brady]
- CTRMN005133-5134 Tobacco Research Group Cites Questions Raised in Heart Statement [Lack of Evidence Proposes New Questions and Doubts About Cardiovascular Disease]
- CTRMN005135-5137 New Evidence Shows Complexities of Lung Cancer, Scientist Says [Hundreds of Studies Indicate Many Factors Contribute to the Complex Chain That May Result in Lung Cancer, No One Can Figure Out the Right Factor and Still the Reported Lung Cancer Cases Are Rising]
- CTRMN005138-5140 New Grants to Scientists Made by Tobacco Research Group [Research Grants Totalling $523,000 Made to 40 Scientists This Year]
- CTRMN005141-5144 Cancer Research Opens Up New Areas, Extra Funds Appropriated for Study [TIRC Stepping Up Financial Support of Independent Health Research]
- CTRMN005145-5147 Scientists in 11 States Get Research Grants for Tobacco-Health Studies [17 Research Grants Totaling Nearly $200,00 Awarded to Scientists in 11 States for Studies of Tobacco Use and Health]
- CTRMN005148-5151 New Direction for Tobacco-Health Research in '61, Says Chairman of Tobacco Industry Research Committee [Future Research to Concentrate on How Lung Cancer and Heart Disease Originate]
- CTRMN005152-5160 Research on Smoking and Health Discussed by Scientific Advisory Board to T.I.R.C. [Health Research Expansion Called for in 22 Specific Areas]
- CTRMN005161-5162 Scientist Reports on Research Progress As T.I.R.C. Boosts Funds to $4,650,000 [Dr. Clarence Cook Little Proposed Steps for Medical Research]
- CTRMN005163-5163 Nation's Medical Students Offered Research Fellowships by Tobacco Research Group [Program Designed to Encourage Research As A Career]
- CTRMN005164-5168 Scientists in 14 States Get Research Grants for Tobacco-Health Studies [Fifteen Grants for New Research Announced]
- CTRMN005169-5173 Tobacco Industry Research Committee Adds $800,000 for New Research [Emphasis Put on Viruses, Bioassay, Psychological and Physiological Research]
- CTRMN005174-5176 ""Significant Developments" in Cancer Research Reviewed in Annual Report by Dr. C.C. Little" [Scientific Findings of the Past Year Reviewed]
- CTRMN005177-5179 Tobacco Research Group Offers Fellowships to Medical Students to Spur Interest in Research Work [Program Designed to Encourage Career in Research]
- CTRMN005180-5180 Tobacco Research Committee Chairman Comments on Mouse Skin Painting [Harmless Everyday Substances Can Cause Cancer in Laboratory Animals]
- CTRMN005181-5182 Smoking-Health Situation Calls for Facts, Not Emotions, Says Hartnett [Repetition Does Not Add to Scientific Knowledge]
- CTRMN005183-5217 Smoking-Health Situation Calls for Facts, Not Emotions, Says Hartnett [Repetition Does Not Add to Scientific Knowledge]
- CTRMN005218-5224 52 Additional Research Grants Made by Tobacco Industry Group [Money for Studies Designed to Give New Leads to Lung Cancer and Other Health Problems]
- CTRMN005225-5225 Medical Student Fellowships Offered by Tobacco Research Group [Program to Encourage Research]
- CTRMN005226-5228 Gaps Still Exist in Knowledge of Lung Cancer and Heart Disease, Says Little [Multiple Factors and Influences That Contribute to Lung Cancer Unknown]
- CTRMN005229-5230 Scientific Director of Tobacco Industry Research Committee Comment on Resolution by American Heart Association [TIRC Welcomes Recognition of Need for Further Research to Determine Full Facts About Smoking]
- CTRMN005231-5234 Tobacco Committee Adds $1 Million for Continuing Research Studies [Scientific Advisory Board Assured TIRC Will Provide More Funds]
- CTRMN005235-5235 [Scientific Director of TIRC Sent Telegrams to the Surgeon General and the President of the Ama]
- CTRMN005236-5236 [Ama Supports Research on Tobacco and Health]
- CTRMN005237-5239 [TIRC Renamed and Reorganized]
- CTRMN005240-5241 Dr. Howard B. Andervont Named to the Scientific Advisory Board [Editor of the Journal of the National Cancer Institute Appointed]
- CTRMN005242-5277 Tobacco Industry Group Awards $817,165 for Health Research [37 Additional Research Grants Have Been Awarded by the Ctr]
- CTRMN005278-5282 Scientific Director C.C. Little Reports Decade of Tobacco-Health Research [Findings on What Diseases Smoking Can Cause]
- CTRMN005283-5286 Council Awards $500,000 for Tobacco and Health Research [Number of Grants Awarded for Tobacco Use and Health Research]
- CTRMN005287-5291 Summary of the Testimony of Clarence C. Little Before the Senate Commerce Committee [Discussion on Cancer and How It Affects Our Bodies]
- CTRMN005292-5319 Council Awards $514,767 for Tobacco and Health Research [Number of Grants Awarded to Scientist Over the Period of 10 Years]
- CTRMN005320-5348 Tobacco - Health Studies Reviewed in Annual Report [Discussion on Cigarette Smoking Being Helpful with Causing Diseases in Smokers]
- CTRMN005349-5367 Tobacco and Health Research Awards Pass $9 Million Total [Grants Given to Scientist Studying Matter Related to Tobacco Use and Health]
- CTRMN005368-5375 Tobacco-Health Research Grants Awarded New York Scientists [Scientists Approved to Continue Research on Lung Cancer and Other Diseases]
- CTRMN005376-5382 Tobacco - Health Studies Reviewed in Annual Report [Studies of the Respiratory System in Experimental Animals and Human Patients Especially on Causes of Pulmonary Cancers]
- CTRMN005383-5384 [Opinions of Scientists That There Is No Relationship Between Smoking and Disease]
- CTRMN005385-5387 New Tobacco-Health Research Grants Total $2 Million [Number of Approved Grants for Studies on Tobacco Use and Health]
- CTRMN005388-5388 Furst Becomes Consultant to Tobacco Research Council [Dr. Furst Advise to Council on Programs Sponsored by Them]
- CTRMN005389-5393 Studies Raise Questions About Smoking As Health Hazard [Numerous Studies Done to Show What Effect Smoking Had on Our Health]
- CTRMN005394-5400 Broad Review of Tobacco-Health Picture Covered in Dr. Little's Latest Report Lung Cancer, Heart Disease, Chronic Pulmonary Ailments Are Complex in Nature, Says Noted Researcher Genetic and Environmental Factors May Be Involved Reports Scientific Director of Council for Tobacco Research [Recent Research Finding on Lung Cancer, Heart Disease and Chronic Pulmonary Ailments]
- CTRMN005401-5404 Significant Smoking-Health Finding Covered in Report by Dr. C.C. Little [Findings From Independent Scientists on Smoking and Health]
- CTRMN005405-5408 New Tobacco-Health Grants Announced; One Helps Revive Framinghan Heart Study [Awards Granted to Independent Scientists Researching Tobacco and Health]
- CTRMN005409-5412 New Scientific Findings About Cancer, Heart Disease, the Lung, Other Areas, Reported by Council for Tobacco Research [New Findings From Independent Scientists Relating to Tobacco and Health Issue]
- CTRMN005413-5415 New Smoking-Health Studies Boost Total to $23-Million [Council Awards More Grants to the Study of Lung Cancer, Viruses and Cancer, Heart Disease, and Chronic Pulmonary Ailments]
- CTRMN005416-5418 Progress in Tobacco-Health Research Achieved: Machines That Simulate Human Smoking [Machines to Help Scientists Effectively Study Smoke and Health Issues]
- CTRMN005419-5421 Noted Cancer Scientist Named Scientific Director of the Council for Tobacco Research [Dr. Hockett Who Was Acting Scientific Director Got Promoted to Research Director]
- CTRMN005422-5425 Massive Cancer Study Using Made-to-Order Mice [Study Using Mice to See If Human Lung Cancer Can Be Induced Regularly]
- CTRMN005426-5427 Tobacco Research Group Announces New Studies [12 New Studies Have Been Funded to Study Generic Factors in Lung Cancer and Emphysema and the Possible Influence of Nicotine on Fetal Growth]
- CTRMN005428-5429 Studies of Twins Expanded by Tobacco Research Group [Human Twins Used for Study to Determine Effects of Environment Agents on Various Diseases]
- CTRMN005430-5432 News About Smoking and Health Study Interaction of Genetic and External Influences in Lung Cancer [Studies Show That Only Minority of Smokers Get Lung Cancer Therefore Lung Cancer May Be Caused by Genetic Characteristics or External Influences Which People Have Been Exposed]
- CTRMN005433-5434 New Smoking and Health Grants Made by Tobacco Research Council [New Studies Have Received Grants to Continue Researching on Smoking and Health]
- CTRMN005435-5435 Yeaman Assumes Leadership of Council for Tobacco Research [Addison Yeaman Succeeds H.H. Ramm for Chairman and President of the Council for Tobacco Research]
- CTRMN005436-5438 14 New Studies Funded by Tobacco Research Council [Grants Awarded to Studies for Inhibition of Cancer by Different Chemicals, the Influence of Nicotine on Pregnancy and the Effects of Cigarette Smoke on the Body's Disease Fighting System]
- CTRMN005439-5441 Progress Being Made in Research on Emphysema [Scientist Discover Ways to Help Defend Against Emphysema]
- CTRMN005442-5444 14 New Smoking-Health Projects Are Approved [Recent Research Studies Dealing with Smoking and Health Have Been Given Grants]
- CTRMN005445-5446 Grants Awarded for New Smiking-Health Studies [Scientists Were Approved for Studying of Certain Enzymes in Human Lung Cancer and Emphysema]
- CTRMN005447-5448 Tobacco Research Report Discusses Heart Disease [Studies Have Found Progressive Atherosclerosis Rank First As Number One As Causes of Death From Cardiovascular Disease]
- CTRMN005449-5451 Grants Awarded for New Smoking-Health Research [New Studies Have Been Approved for Marker Substance That May Indicate Presence of Lung Cancer and on Smoking and Pregnancy]
- CTRMN005452-5453 Tobacco Research Group Funds New Smoking-Health Projects [A New Study for Relationship of Childhood Respiratory Disease to the Development of Adult Chronic Lung Disease]
- CTRMN005454-5455 Tobacco Research Group Reports... Funds for Smoking-Health Studies Pass $46,000,000 [Amount Council Has Given to Scientist for Research]
- CTRMN005456-5458 $5.9 Millions Given for Smoking-Healths Studies [Council Has Given Millions Over the Years to Researchers]
- CTRMN005459-5460 Tobacco Research Group Says... Continued Research Needed to Find Causes of Cancer and Other Major Diseases [Council Pledges to Continue to Give Financial Support to Scientists Studying Smoke-Health Issues]
- CTRMN005461-5462 $6 Million Granted for Smoking-Health Studies [Millions Given to Scientist for Further Study]
- CTRMN005463-5465 Tobacco Research Group Continues Funding for Independent Scientists [Council Has Provided Millions Over the Years to Researchers and Will Continue to Do So]
- CTRMN005466-5467 $5.5 Million Given for Smokin-Health Studies [Council Has Given Millions to New and on Going Studies Over the Years]
- CTRMN005468-5469 Annual Report Issued by Tobacco Research Group [Over 1.5882 Reports From Scientists Acknowledging Support From the Council Have Been Published]
- CTRMN005470-5473 $6 Million Awarded for 34 New Smoking-Health Studies [Millions Were Given to Scientists with New Studies and Continuing Ones From the Council]
- CTRMN005474-5474 Ctr's Latest Report Sets Abstract Record [More Reports Were Published From Scientists Acknowledgingg Support From Council for Tobacco Research Than Any Other Report Published in the Past]
- CTRMN005475-5475 Scientists Show... Growing Interest in Doing Smoking and Health Studies [Growing Number of Application Have Gone to the Council of Tobacco Research for Funding on Smoke Related Diseases]
- CTRMN005476-5479 $7 and A Half -Million Awarded for Smoking-Health Research [Millions Given to Scientists for Studying Lung Disease]
- CTRMN005480-5481 Council for Tobacco Research Announces... Hoyt and Hockett Retire After 30 Years: Gertenbach Is Named New President [Introduction to President of the Council for Tobacco Research]
- CTRMN005482-5482 Ctr's Annual Report Sets Abstract Record [the Number of Reports Acknowledging Support by the Council of Tobacco Research Is More Today Than It Was Years Ago]
- CTRMN005483-5485 Findings Published on Cigarette Smoke Inhalation Study with Mice [Results From Study Show That Smoke Did Not Produce Any Squamous Cell Lung Cancer]
- CTRMN005486-5525 Statement of Dr. Clarence Cook Little, Scientific Director, Tobacco Industry Research Committee, at Press Conference, University Club, New York City, June 15, 1954 [Regarding Relationship Between Lung Cancer and Tobacco]
- CTRMN005526-5533 "Transcript of Edward R. Murrow's First Tv Show on "Cigarettes and Lung Cancer"" [Regarding Experiments That Show That Cigarette Smoking Increases Chances for Lung Cancer]
- CTRMN005534-5541 "Transcript of Edward R. Murrow's Second Tv Show on "Cigarettes and Lung Cancer"" [Regarding Issue That Cigarette Smoke Does Not Cause Lung Cancer]
- CTRMN005542-5562 the Lung Cancer Problem and the Research Program of the Tobacco Industry Research Committee [Regarding Continuation of Study Dealing with Tobacco and Health]
- CTRMN005563-5573 A Report of Progress [Results From the Study of Smoking and Health Issue Will Greatly Depend on Well Planned and Well-Executed Scientific Research]
- CTRMN005574-5585 Tobacco and the Cardiovascular System the Program of the Tobacco Industry Research Committee [Program Strives to Discover Facts and Relationships Described with Objectivity]
- CTRMN005586-5597 A Search for Facts [Regarding Information Needed to Be Gathered on Smoking and Health Problems to Defend Industry]
- CTRMN005598-5605 the Lung Cancer Problem and the Research Program of the Tobacco Industry Research Committee [Discussion on Different Studies Will Continue to Be Made Until A Answer Is Found]
- CTRMN005606-5607 Cancer Research Guest Editorial Smoking and Lung Cancer Volume 16 [St Regarding Support Given to Scientist for Research]
- CTRMN005608A-5609 "Correspondence Regarding "Smoking and Health"" [Discussion on Researching on Tobacco and Health with Objectivity and Not Be Judgmental]
- CTRMN005608B-5609 Hypfibrinogenemia [Regarding Transfusions and Clotting Mechanism in A Case of Extraordinarily Delayed Post-Partum Hemorrhage]
- CTRMN005608C-5609 Diabetic Children [Admitting Omission of Different Data From Other Sources]
- CTRMN005608D-5609 Revocation of Licenses [Revoking of Registration From Dr. Louis A. Scinta]
- CTRMN005610A-5613 Mayo Clinic Head Believes Smoking Not Cancer Cause Tobacco and Health Volume 1 Number 1 [Smoking Not Believed to Be Cause of Lung Cancer, According to Some Noted Physicians]
- CTRMN005610B-5613 Six Experts State Doubts on Smoking-Cancer Theory Tell Congressmen Reasons for Position Tobacco and Health Volume 1 Number 1 [Reasons for Not Accepting Theory That Smoking Causes Lung Cancer]
- CTRMN005610C-5613 New Book Says Tobacco 'scare' Not Justified Tobacco and Health Volume 1 Number 1 [""Science Looks at Smoking"]
- CTRMN005610D-5613 Editors View Smoking-Cancer Tie As Unproved, Open Question Excerpts From Editorials Tobacco and Health Volume 1 Number 1 [Excessive Smoking Probably the Main Cause of Lung Cancer, While Moderate Smoking As Causation of Lung Cancer Has No Scientific Support]
- CTRMN005610E-5613 British Scientist Opposes Campaign Against Smoking Tobacco and Health Volume 1 Number 1 [Sir Ronald Fisher, British Statistician, Refuses to Produce Anti-Smoking Writing, States It As A Cause for Anxiety]
- CTRMN005610F-5613 'pick Your Expert, Take Your Choice' Tobacco and Health Volume 1 Number 1 [Witnesses Linking Cigarettes to Lung Cancer Testify Before House Operations Sub-Committee]
- CTRMN005610G-5613 'still Open Question' Tobacco and Health Volume 1 Number 1 [Authorities on Cancer State That Smoking Is Not Proven to Cause Lung Cancer]
- CTRMN005610H-5613 Smoking and Death Rates Tobacco and Health Volume 1 Number 1 [If Everyone Stopped Smoking There Would Be No Significant Change in Death Rate]
- CTRMN005614-5616 Summary of Comments for Delivery Before: Central Subsection, North Jersey Section, American Chemical Society, Elizabeth, New Jersey [Review of the Chemical Analysis of Cigarette Smoke and Investigations of Smoking and Lung Cancer]
- CTRMN005617-5620 the Public and Smoking Fear or Calm Deliberation? [How Doubt, Suspicion and Fear May Affect the Deliberation of Whether Cigarette Smoking Causes Lung Cancer or Other Ailments]
- CTRMN005621A-5624 TIRC Reports Progress in Smoking-Health Research Tobacco and Health Volume 1 Number 2 [Too Many Unknowns Exist Concerning Lung Cancer to Warrant Conclusions Citing Smoking As Causation of Lung Cancer]
- CTRMN005621B-5624 'tar' Misnomer for Condensed Smoke Tobacco and Health Volume 1 Number 2 [Difficulties in Analyzing Tobacco Smoke Make Tobacco Tar A Misnomer]
- CTRMN005621C-5624 New Statistics Contradict Anticigarette Theory Tobacco and Health Volume 1 Number 2 [Cigarette Smoking May Be Compatible with Normal Health Report on Done Smokers Who Have Longer That Average Life Span]
- CTRMN005621D-5624 TIRC Funds for Smoking Research Now Over $2,000,000 Tobacco and Health Volume 1 Number 2 [Scientific Advisory Board Approves 52 Grants and Renewals in 1957 Totalling $550,000]
- CTRMN005621E-5624 Press Questions Anti-Smoking Plan Tobacco and Health Volume 1 Number 2 [State-Supported Campaign Against Cigarettes Warranted in New York]
- CTRMN005621F-5624 Study Suggests Bronchitis May Be Prime Factor in Lung Cancer Tobacco and Health Volume 1 Number 2 [Preliminary Study at Beatty Institute Favors Bronchitis As A Factor of Lung Cancer]
- CTRMN005621G-5624 Doctors' Comments on Smoking-Health Tobacco and Health Volume 1 Number 2 [Increasing Number of New Chemicals in the Atmosphere at Fault for Rise in Cancer]
- CTRMN005621H-5624 Nation-Wide Lung Tissue Study Now Being Evaluated Tobacco and Health Volume 1 Number 2 [TIRC Studying Lung Tissues From 1,600 Persons]
- CTRMN005625-5648 Biological Aspects of Cancer Research Journal of the National Cancer Institute Vol. 30, No. 3 [St Background Research and New Information on Cancer Studies]
- CTRMN005649-5654 Interview the Cigaret Smoker and Lung Cancer Reprinted From Modern Medicine, Vol 26 [St Advises on Smoking and Its Relation to Health]
- CTRMN005655-5660 Comments on the Mortality of Smokers and Non-Smokers. A Paper by Harold W. Dorn Before the American Statistical Association Dec. 27, 1958 [Reflections on Figures Presented in Dorn's Paper]
- CTRMN005661-5671 An Experimentalist Looks at Statistics on Smoking [Reflections on the Figures in Dorn's Paper]
- CTRMN005672-5672 Letters to the Times Findings on Smoking [Statistical Proof of Link Between Smoking and Cancer Denied]
- CTRMN005673-5683 A Brief Review of the Smoking-Lung Cancer Theory [Review of Data Known on the Relation Between Cigarette Smoking and Lung Cancer]
- CTRMN005684-5686 Cancer-the Research Approach [Discussion on Cancer and A Category of Factors Which May Play Roles in Cause and Development of Cancer]
- CTRMN005687-5692 [Address Before the Burley and Dark Leaf Tobacco Export Association, Inc. Information About the Research Program Supported by the TIRC]
- CTRMN005693-5697 Some Phases of the Problem of Smoking and Lung Cancer the New England Journal of Medicine Vol. 264 No. 24 [St Disputes Findings That Smoking Causes Lung Cancer]
- CTRMN005698-5704 Some Aspects of the Lung Cancer Problem Reprinted From Punjab Medical Journal Vol. Xi No. 7 [St Discussion of Relationship of Cigarette Smoking to Lung Cancer]
- CTRMN005705-5735 Current Knowledge of Tobacco and Health [Discussion of Experimental Attack on Lung Cancer and Tobacco Use]
- CTRMN005736-5739 Cigarettes-Why More Research? Reprinted From the Yale Scientific Magazine [St Comments on the Uncertainties of the Correlations Between Cigarette Smoking and Lung Cancer]
- CTRMN005740-5740 Why Do People Think That Quitting Smoking Affects Their Appetite or Their Weight? the Apothecary [St Comments on the Scientific Basis of How Smoking Affects Hunger]
- CTRMN005741-5754 Address to Be Delivered by Dr. Clarence Cook Little, Scientific Director, the Council for Tobacco Research - U.S.A. At A Dinner Honoring the Centennial of the University of Kentucky and the Burley Tobacco Industry Lexington, Kentucky January 12, 1965 [Talk Addressing Research Programs of the University of Kentucky]
- CTRMN005755-5772 Communications and the Biological Sciences [Brief Discussion of Principles That Should Inspire and Guide Communications in the Biological Sciences]
- CTRMN005773-5785 Perspectives in the Experimental Approach to the Human Lung Cancer Problem [Experimental Research on Lung Tumors in Animals May Lead to Insights on Human Lung Cancer]
- CTRMN005786-5798 Tobacco and Health Research [Elaboration on the Purpose, Research Practices and Studies of the TIRC]
- CTRMN005799-5805 Tobacco and Health Research [Discussion of Experimental Studies by the TIRC Concerning Smoking and Health]
- CTRMN005806-5813 the Research Perspective on Smoking and Health [Discussion on the Search for Causes of Diseases with Which Smoking Has Been Associated]
- CTRMN005814-5820 Tobacco and Health Research [Discussion of Studies on Cigarettes and the Diseases Statistically Associated with Smoking]
- CTRMN005821-5834 Tobacco and Health Research - Where Shall We Go From Here? [Suggestions for Continuing Studies and Research on Cigarette Smoking and Health]
- CTRMN005835-5852 A Look Ahead Smoking and Health - Where Do We Stand? [Talk on Chronic Diseases and Factors of Their Causation and Development in Relation to Cigarette Smoking]
- CTRMN005853-5854 Smoking-Disease Links Continue to Lack Scientific Proof [Discusses the Role of the Council for Tobacco Research]
- CTRMN005854-5854 Lawrence Promoted to Vp Post at Mmi [Jack Riddle Announces the New Vp of Micro-Magnetic Industries]
- CTRMN005854A-5854 Philip Morris Expands Promotional Allowances [Discusses Special Offers Made to Philip Morris Vendors]
- CTRMN005855-5882 Chapter 3 the Tobacco Health Issue: An Overview of Medical Research [St Questions Methodology of Experiments Where the Sole Objective Was the Attempt to Induce Tumors]
- CTRMN005883-5900 the Research Program (Cancer Segment) of the Council for Tobacco Research - U.S.A., Inc. Presentation Before the Tobacco Working Group [Describes the Concept, Plan, and Purpose of the Council for Tobacco Research]
- CTRMN005901-5902 Smoking Prevention Education Act Hearings Before the Subcommittee on Health and the Environment of the Committee on Energy and Commerce House of Representatives Ninety-Eighth Congress First Session on H.R. 1824 [Statement of Sheldon C. Sommers]
- CTRMN005903-5919 [Regarding Anti-Smoking Bill]
- CTRMN005920-5931 Hearings Before the Subcommittee on Health and the Environment of the Committee on Energy and Commerce House of Representatives Ninety-Eighth Congress First Session on H.R. 1824 March 9 and 17, 1983 Serial No. 98-8 Statement of Robert Casad Hockett Regarding H.R. 1824 [Disputes Findings Set Forth in H.R. 1824 Regarding Cancer, Cardiovascular Disease, Atherosclerosis and Emphysema]
- CTRMN005932-5932 Hearings Before the Committee on Labor and Human Resources United States Senate Ninety-Eighth Congress First Session on S. 772 May 5 and 12, 1983 [Concerning Smoking Prevention Health and Education Act of 1983]
- CTRMN005933-5940 Statement of Sheldon C. Sommers, M.D., Consultant in Pathology, Lenox Hill Hospital, New York, N.Y. [Comments on Smoking Prevention Health and Education Act]
- CTRMN005941-5963 Hearings Before the Committee on Labor and Human Resources United States Senate Ninety-Eighth Congress First Session on S. 772 to Promote Public Health by Improving Public Awareness of the Health Consequences of Smoking and to Increase the Effectiveness of Federal Health Officials in Investigating and Communicating to the Public Necessary Health Information, and for Other Purposes Statement of Robert Casad Hockett Regarding S. 772 [Disputes Methodology of Experiments Which Expose Animals to Smoke]
- CTRMN005964-6009 Hearings Before the Subcommittee on Health and the Environment of the Committee on Energy and Commerce House of Representatives Ninety-Seventh Congress Second Session on H.R. 5653 and H.R. 4957 March 5, 11, and 12, 1982 Serial No. 97-106 [Disputes Methodology of Experiments to Demonstrate That Cigarette Smoking Can Cause Lung Cancer in Animals]
- CTRMN006010-6012 Testimony of Dr. Robert C. Hockett During Hearing on Cigarette Smoking and Health Before the Subcommittee on Oversight and Investigations of the House Committee on Interstate and Foreign Commerce, October 5, 1978 [Responds to Question Regarding Research on Health and Smoking]
- CTRMN006013-6023 Statement of Robert C. Hockett, Ph.D. Before the Subcommittee on Oversight and Investigation of the Committee on Interstate and Foreign Commerce in Response to the Letter Dated September 27, 1978 From the Chairman of the Subcommittee to William U. Gardner, Ph.D., Scientific Director, the Council for Tobacco Research - U.S.A., Inc [Discusses the Purpose of the Council for Tobacco Research]
- CTRMN006024-6069 Hearings Before the Subcommittee on Health of the Committee on Labor and Public Welfare United States Senate Ninety-Fourth Congress Second Session on S. 2902 February 19, March 24, and May 27, 1976 [Disputes Scientific Basis of S. 2902]
- CTRMN006070-6125 Hearings Before the Consumer Subcommittee of the Committee on Commerce United State Senate Ninety-Second Congress Second Session on S. 1454 Serial No. 92-82 [Discussion of Cigarette-Smoking and Peptic Ulcers]
- CTRMN006126-6135 Report of the Scientific Director [St]
- CTRMN006136-6189 Hearings Before the Consumer Subcommittee of the Committee on Commerce United States Senate Ninety-Second Congress Second Session on S. 1454 February 1, 5, and 10, 1972 [Discusses Edimeological Comparisons Between Smokers and Non-Smokers]
- CTRMN006190-6200 [Bibliography Listing Over 1,275 Articles and Books About Tobacco and Disease]
- CTRMN006201-6311 [Articles About Tobacco and Disease]
- CTRMN006312-6321 Hearings Before the Consumer Subcommittee of the Committee on Commerce United States Senate Ninety-Second Congress Second Session on S. 1454 to Amend the Federal Cigarette Labeling and Advertising Act to Require the Federal Trade Commission to Establish Acceptable Levels of Tar and Nicotine Content of Cigarettes [Statement of Dr. Sheldon C. Sommers]
- CTRMN006322-6348 Hearings Before the Consumer Subcommittee of the Committee on Commerce United States Senate Ninety-Second Congress Second Session on S. 1454 to Amend the Federal Cigarette Labeling and Advertising Act to Require the Federal Trade Commission to Establish Acceptable Levels of Tar and Nicotine Content of Cigarettes [Statement of Dr. Robert Casad Hockett]
- CTRMN006349-6359 Hearings Before the Consumer Committee of the Committee on Commerce United States Senate Ninety-Second Congress Second Session on S. 1454 to Amend the Federal Cigarette Labeling and Advertising Act to Require the Federal Trade Commission to Establish Acceptable Levels of Tar and Nicotine Content of Cigarettes [Statements of Dr. Sheldon C. Sommers and Dr. Robert C. Hockett]
- CTRMN006360-6370 Hearings Before the Consumer Subcommittee of the Committee on Commerce United States Senate Ninety-Second Congress Second Session on S. 1454 to Amend the Federal Cigarette Labeling and Advertising Act to Require the Federal Trade Commission to Establish Acceptable Levels of Tar and Nicotine Content of Cigarettes [References Reporting on Tobacco and Nicotine]
- CTRMN006371-6412 Hearings Before the Committee on Interstate and Foreign Commerce House of Representatives Ninety-First Congress First Session on H.R. 643 A Bill to Amend the Federal Cigarette Labeling and Advertising Act with Respect to the Labeling of Packages of Cigarettes and for Other Purposes (and Similar Bills) [Statement of Dr. Sheldon C. Sommers]
- CTRMN006413-6492 Hearings Before the Committee on Commerce United States Senate Eighty-Ninth Congress First Session on S. 559 and S. 547 Bills to Regulate Labeling of Cigarettes and for Other Purposes [Statement of Dr. Clarence C. Little]
- CTRMN006493-6533 Hearings Before the Committee on Interstate and Foreign Commerce House of Representatives Eighty-Ninth Congress First Session on H.R. 2248 A Bill to Amend the Federal Food, Drug, and Cosmetic Act So to Make That Act Applicable to Smoking Products [Statement of the Council for Tobacco Research U.S.A. History and Organization]
- CTRMN006534-6540 Hearings Before the Committee on Interstate and Foreign Commerce House of Representatives Eighty-Ninth Congress First Session on H.R. 2248 A Bill to Amend the Federal Food, Drug and Cosmetic Act So As to Make That Act Applicable to Smoking Products [Statement of Clarence Cook Little, SC.D.]
- CTRMN006541-6548 Hearings Before the Committee on Interstate and Foreign Commerce House of Representatives Eighty-Ninth Congress First Session on H.R. 2248 A Bill to Amend the Federal Food, Drug, and Cosmetic Act So As to Make That Act Applicable to Smoking Products [Statement of Robert Casad Hockett, Ph.D.]
- CTRMN006549-6577 False and Misleading Advertising (Filter-Tip Cigarettes) Hearings Before A Subcommittee of the Committee on Government Operations House of Representatives Eighty-Fifth Congress First Session [Statement of Dr. Clarence Cook Little]
- CTRMN006578-6611 False and Misleading Advertising (Filter-Tip Cigarettes) Hearings Before A Subcommittee of the Committee on Government Operations House of Representatives Eighty-Fifth Congress First Session [Statement Concerning the Origin and Purpose of the Tobacco Industry Research Committee and Its Proposed Functions]
- CTRMN006612-6614 False and Misleading Advertising (Filter-Tip Cigarettes) Hearings Before A Subcommittee of the Committee on Government Operations House of Representatives Eighty-Fifth Congress First Session [Hartnett Cites Scientists Doubting Smoking-Cancer Theory]
- CTRMN006615-6618 Research Into Smoking and Health [Arguments Against Tobacco Cancer Link]
- CTRMN006619-6623 [Study to Examine Reported Causes of Death in Each of 17 Regions in Houston Specifically the Five Major Respiratory Diseases]
- CTRMN006624-6624 A Frank Statement to Cigarette Smokers [Industry Promotes Research Into Tobacco Disease Link]
- CTRMN006625-6625 the Council for Tobacco Research - U.S.A., Inc. Board of Directors [Members of the Board]
- CTRMN006626-6627 the Council for Tobacco Research - U.S.A., Inc. Scientific Advisory Board [Members of the Board]
- CTRMN006628-6634 No. E-121,486 I. D. Rogers, Individually and As Independent Executor of the Estate of Marjorie Helen Rogers, Deceased; Et Al Vs. R. J. Reynolds Tobacco Company, Et Al in the District Court of Jefferson County, Texas 172nd Judicial District Third Amended Notice of Intention to Take Oral Deposition [Matters on Which Ctr Witnesses Must Be Knowledgeable]
- CTRMN006635-6967 Deposition of Dr. James Glenn [Deposition of Glenn in the Matter of Broin]
- Author
- Tirc
- Becker, R., Univ Houston
- Request
- 118
- Type
- APPLICATION FOR GRANT
- Box
- 002
- UCSF Legacy ID
- qnq30a00
Page count mismatch (files 719, split 540)
Document Images
N
C
TO6ACCO INDUSTRY RESEARCH COMMITTEE
150 EAST FORTI SECOND STREET KEW YORK 17, N. Y.
Appicc8on For R...ord,Groni
THIS DOCU6'EA1T SUBJECT T0. AUG.
20, 1°_85 NCN DISSEMINATION ORDE.R
IN ROGERS AND DUKE CASES.
Dow, November 11, 1959
1. KoT" of 4wa;qah 1 Dr. Ralpb Becker
2. Tt+i.: 'p.csociate Professor of Chemistry
s.kwo%mon University of Houston
s AddmmL- 3801 Cullen Blvd.
Houston, Texas
a. P.oi«+orsWbi.cr An Investigation of the Spectral and Chromatographic
. Characteristics of Aromatic Hydrocarbons.
C
S. Daotl.d Pion el Proe.dvr. (Uw rrwrs~ iid+ if edd'itionol ipooa ia n..d.d): This projec t at pres
e:1:
is conceived as having two principal purposes: (1) A study of the
use of high temperature gas-liquid partition chromatography for
analysis of aromatic hydrocarbons and comparison of this analysis
with electronic spectral data. (2) A concentrated effort on develop-
ing correlations of fundamental spectroscopic experimental and
theoretical data and the relation of these to carcinogenic act_:ity.
I. No completely satisfactory method is available for :he
analysis and separation of aromatic hydrocarbons. Conventional
techniques involving liquid solvents and solid adsorbents do not
provide detailed analysis and, in addition, may be restricted to minute
quantities (such as paper chromatography) or may require too large
a quantity compared to that available. Gas-liquid partition poten-
t:ally offers a unique combination of characteristics. It is
capable of analyzing minute quantities of materials (in the range
of a microgram). In addition, the technique provides high resolu-
~ion capability for compounds having very similar properties. (such
as.the isomeric xylenes). Finally, it is poss_ble to analyze and
separate working quantities of materials (mg and ml batche:.).
Conventional units are limited to a maximum temperature of ap-
proximately 225°C. The construction of special high temperature employing sapphir.e insulators is
planned. Th_s unit will allow
temperatures of 400 C°to be attained, if required.
CONFI[)E.NTIAI.: MINNESOTA
TOEiACCO LITIGATION
CtR 1897
c
r;
L. i R i i i i 0ti.+r 22224
.
. V
i . .
TNIS DOCU:.:_'tT cD;ECT TO /'D,
20, 19s3 N;;N.D;SSE&i1N:~T1oN ORu~
1N ROGERS AND DUKE CASES.
f. iudpa Kon:
f4bria
P.rewr+.m 6Ruipn~.r+t
Owrfi.od
O16.r
18600
30.0-0
00
4240-
10an
T,+ot 31840
pwavi,n,t We,k, Three years are des irable in order to take advantage
-mew developments in the instrumentation phase and continuing new
C
A
-.
ar~dSx~IFA.otbbk: Staff: Dr. A. Zlatkis of the University of Houstor.
will work directly with us on the instrumentation phase. Dr. Zlatkis
bas been very active in the realm of gas-liquid chromatography and
is one of the leaders in the field. He has published several articles
and is al.so a consultant in the field. Graduate students and a-
xesearch assistant are also available. Facilities: Three spectro-
graphs, a spectrophotometer, a densitometer, a monochromator, and
xtecessary auxillary optical supplies.
`ata in the correlation phase.
-
-
7. *Idl+ioaial bqvtr.enntu
(a) Righ Temperature gas-liquid chromotographic unit. This will
be specially constructed by Barber-Colman, Rockford, 111. - approxi-
mately $5,000.
(b) Full-time post-doctoral associate whose effort will be directed
to the correlation phase - $6,200 per 11 months.
40. AddNiawl brfornwtion Onaictuq r.6wn ef work w ah.. proj.ct+ and otf+.r .a,rc.r ef .vpply):
, The author presently holds a grant for study of aromatic hydrocarbons
from the Department of Health, Education & Welfare. This is a three
year grant obtained after the conclusion of a two year grant. The
alppropriations available are primarily for spectral investigation
of the hydrocarbons. Funds are included for a full-time researcc
°:zr,~:-wnsietant and students, chemical compounds, expendable photographic
h
l
d l
d ot
er supp
ies an
ow temperature absorption spectra attachment
e author has been responsible for the collection of some 130 ciiffere-=
omatic hydrocarbons. This includes five complete methyl series and
everal partially complete ones.
//1J'l(Z_dG21i~~
t
i.
W~inw W6c.r of th. kwbvlion
f T D
CONFIDENTIAL: MINNESOTA
TOBACCO LITIGATION
R-ri' i. t i i i 0r.1r~. ~,~ ,~
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TO6ACCO INDUSTRY RESEARCH COMMITTEE
150 EAST FORTY SECOND STREET NEW YORK 17, N. Y.
ApP6cation For R...arch Gront
rfhledrf(utroA .f*:";
Do++: March 29, 1960
1. Nonw of Inv.sfipator:
Lr: Ralph Becker /4.D.
2. Tt+6: Associatr Professor of Chemistry
3. inrn,,,rion The University of Houston
a Addrw: 3801 Cullen Blvd.
Houston 4, Texas
a. Proi.o orsubi.cn An Inrestigation of the Spectral and Chromatographic
Characteristics of Aromatic Hydrocarbons.
S. D.tall.d Plon of Proc.dvr. (Ure rev.nm i+d. N odditionai ~poa is nsd.d): This proj ect at
presel:t
is conceived as having two principal purposes: (1) A study of the
use of high temperature gas-liquid partition chromatography for
analysis of aromatic hydrocarbons and comparison of this analysis
with electronic spectral data. (2) A concentrated effort on develop-
ing correlations of fundamental spectroscopic experimental and
theoretical data and the relation of these to carcinogenic activity.
I. No completely satisfactory method is available for
the analysis and separation of aromatic hydrocarbons. Conven:ior.al
techniques involving liquid solvents and solid adsorbents do not
provide detailed analysis and, in addition, may be restricted to
minute quantities (such as paper chromatography) or may require
too large a quantity compared to that available. Gas-liquid parti-
tion potentially offers a unique combination of characteristics.
It is capable of analyzing minute quantities of materials (in the
range of a microgram). In addition, the technique provides high
resolutiot, capability for compounds having very similar properties,
(such as the isomeric xylenes). Finally, it is possible to analyze
and separate working quaatities of materials (mg and ml batches).
Conventional units are limited to a maximum temperature c:
t. approximately 225°C. The construction of special high temperature
u;.it employing sapphire insulators is planned. This unit will
allow temperatures of 4J0°C to be attained, if required.
CONFIDENTIAL: MINNESOTA
TOBACCO LITIGATION
C T R 1900
C i i.. It -- I N 0 0 1 222 6
1
Itl.~ . . . . . .....
20. 155., .;,5LI ~i~..TiON GRuER
IN ROGERS AND DUKE CASES.
Much of the probLn involves the selection of the proper statiorr
ary liquid phases and operating conditions. Several liquid phases
are available and more will become available in the future. Pre-
liminary analysis of a mixture of phenanthrene and two isomeric
methyl derivatives resulted in separation of the phenanthrene and
methyl derivatives and partial separation of the methyl derivatives
themselves. Despite the fact that only one stationary phase has
been utilized thus far and only limited variation of operating
conditions has been accomplished, this is indeed promising.
Because of the extremely rapid developments in detection tech-
niques, capillary columns, new liquid phases and the like, several
years of study is desirable to allow for utilization of the newes:
developments as they appear. The analysis by the above technique
will be studied in relation to the results obtained from electronic
spectral absorption and emission data. This will permit evaluation
of the sensitivity of the spectral data to impurities and in addi-
tion, potentially allow for analysis in those cases where chromato-
graphy is not applicable or successful. Of course, there is gained
the obvious benefit of establishing the nature of the spectra oqta:ned
as due to that of a single compound or mixture of compounds. I::
c=rtain cases, a mixture may contain sufficient quantities of :s:-
purities to cast doubt on the authenticity of the spectrum obta:ned
In these cases, it is anticipated that the chromatographic technique
will provide the means for obtaining a sufficient quantity of a pure
compound for spectral study. Thus, more rigorous spectral criteria
for purity will be obtained. Moreover, any improvement in spectral
accuracy provides a better basis for fundamental theoretical, experi-.
mental and correlation development.
II. In every chemical reaction, some one or combination of
the fundamental molecular properties are involved. These fundamental
properties include energy of states, lifetime of states and quant:m
yield (ratio of number of quanta or molecular reactions out to number
of quanta in). It is obvious that a better understanding of these
properties would provide a broader and more sound basis for inter-
pretation of any reactions involving the molecules.
Although certain correlations have been obtained in this lab-
oratory among carcinogenic activity, absorption and emission spectral
characteristics, a more concentrated effort is required. Prior tc
this, a concentrated study is necessary on the prediction and cor-
relation of molecular properties. The basis for this would be data
already existent and/or coincidentally obtained. Several such
molecular properties include lifetimes of electronic excited states,
location of electronic excited states and location of perturbing
electronic states. In addition, the significance of variations
of such molecular properties between individual and groups of
aromatic hydrocarbons requires more concentrated investigation.
When more information is available regarding tbe correlation of
the fundamental properties, the possible further correlations of
these with carcinogenic activity will have a much greater chance
of success. Moreover, it is inevitable that a more clear under-
standing of the nature and chemical reactivity of the aromatic
hydrocarbons would result.
CONFIDENTIAL: MINNESOTA
TOBACCO LITIGATION
C T R 1901
l~ 25 ['r, i i i ~ S.~ 0~.~ ~. ~, f` ~
01
r
L
THIS DOCUMENT SU3.EGT T0 AUG.
20, 1985 NONDISSEMINATION ORDER
lN ROGERS AND DUKE CASES.
. ....._..,
Solorist . $ 8,385
bp.ndobl. suppai 760
P.rnwn.nt Equtpm.nt 5,000
OV.*h.od -1., ~+~
p1t,,, 3 50
to,o~ $15,919
Q Wdp.t Pion:
7. f,nbopof.da,rononotwort: Three years are desirable in order to take
advantage of new developments in the instrumentation phase and
cDntinuing new data in the correlation phase.'
t. hdtnisondswff Arotbbl.: Staff: Dr. A. Zlatkis of The University of
Houston will work directly with us on the instrumentation phase.
Dr. Zlatkis has been very active in the realm of gas-liquid
chromatography and is one of the leaders in the field. He has
published several articles and is also a consultant in the field.
Graduate students and a research assistant are also available. .
Facilities: Steinheil Universal Spectrograph/, Model G.H. with
f/3 coated glass optics; 3 coated glass prisms; Beckman Spectro-
hotometer, Mo 1 p automatiq re ordi ran e 21~ ~u to 2800 mu;
9. ~ddironoi~vir.n»nra: ~aci~ities continue~ at ~~~tom ~Z pa e
(a) High Temperature gas-liquid chromatographic unit. This will
be specially constructed by Barber-Colman, Rockford, Ill. - approxi-
mately $5,000.
(b) Full-time post-doctoral associate, whose effort will be directed
to the correlation phase - $6,200 per 11 months.
10. Additioncl Inforn+ation (Includinp r.btion of woric to o1h.r proj.ch and orh.r sovrca of wpply):
The author presently holds a grant for study of aromatic hydro-
carbons from the Department of Health, Education & Welfare. This
is a three year grant obtained after the conclusion of a two year
grant. The appropriations available are primarily for spectral
investioation of the hydrocarbons. Funds are included for a full-
time research assistant and students, chemical compounds, e:;pendable
photobraphic and other supplies and a low temperature absorption
spectra attachment.
sipnofvrs
system, darkroom, refrigerator and deep frjeezp.
cells of Pyrex, Corex and fused quartz; phosphoroscope; vacuum
The author has.been responsible for the collection of some 130
different aromatic hydrocarbons. This includes five complete
methyl series and several partially completed ones.
Facilities (continued): Hilger medium visible-infrared glass spec-
trograph; Bausch & Lomb grating monochromator; Hilger quartz prism
monochromator; light sources and power supply; special made optical
.-,
Wdnw OlFiar of fi+. InttfAMion
CONFIDENTIAL: MINNESOTA
TOBACCO LITIGATION
C T R 1902
tr i {'r. i iiq 0 ti.+T2G.2 6
DOCUrENT Su6;E0T T;
20, 1985 N0NDISSEMINATION
` GarC l 01f a s c 11 /er, phy rrt e c.l eJ y e ,~1 C ti c r+c i S fY yjN ROGERS AND DUKE CASES.
' GoMht, t.ttL. TO6ACC(% INDUSTRY RESEARCH COMMITTEE ,tSf/Q R1
150 EAST FURTY SECOND STREET NEW YORK 17, N. Y.
Oy .Tj cioson
OrV t j tt4- 81
C
t
AP. LICATIOh FOR RENEWAL OF RESEARCH GP.Ah'T
DQw. February 9. 1961
1. Nom* of tnwa+qoron p= Ralph 5. Becker#0 ph.,D.
2- n+: Associate Profes-or of Chemistry
3. hwfi"on University of Houston
a Aarew- 3801 Cullen Boulevard
Houston, Texas
a. PwF«i«subi.ct: An Investigation of the Spectral and Chromatographic
Characteristics of Aromatic Hydrocarbons.
S. Deldil.d Plan of Procsdvr. (Uie nvKSm wd. if oddtiw+o) tpow iu n..d.d): Basically a continua-
tion grant is requested. The future program will invoive the
.study of the two principle portions as outlined irn the original
application for research grant. Some additional approaches to
one portion of the project is anticipated.
I. In addition to the study of the separatiorn of aromatic
hydrocarbons by gas chromatoraphy, a simultaneous study of electron
capture (electron affinity spectroscopy) will be carried out. This
technique is new and has some potentially exciting fundamental
aspects. The method was first discussed by Lovelock and Lipsky,
J. Am. Chem. Soc.4-t`riew review by Lovelock has just appeared,
Analyt. Chem, 42,t*162 (1961). In essence, the technique is a
method for oua_itative identification of functional groups. How-
ever, other facets relative to the aromatic hydrocarbon probleW
appear to be potentially important. For example, preliminary
data indicated that only one of the two isomeric tricyclics
(phenan;,hrene-anthracene) shows electron capture. The reason
for this is not known. The author believes there is a fundamental
reascn why this is true. For example, this fact could be a func;.=cn
of the relative energies of the singlet and/or triplet levels
of the molecule. On the other hand, it could be a function of
the difference of the molecular or electron distribution syrr.te:.-y.
There is not sufficient data to decide these factors. Consecuer.tly,
during the periot cf the visit of Dr. Lovelock arn accelerated,
CONFIDENTIAL: MINNE:SOTA
TOBACCO LITIGATION
C T R 1903
CTR ~°~h~ c~~~~~9
THIS DOCUtdE~~'T SUBJECT TO AUG.
20, 1985 NONDISSEA4IN.4TION ORDER
1N ROGERS AND DUKE CASES.
concci,ted study of large number of aromatic hydrocarbons will be
carried out. Once this is accomplished, correlation will be
attempzed between the results and fundamental molecular properties.
Unfortunately, the information available regarding application of
this technique to aromatic hydrocarbons is nearly non-existent
and .herefore it is not possible at the present time to be more
definitive than the foregoing. However, it is obvious from the
one eYample that this technique may offer a new approach to the
study of electron affinity of molecules which can be correlated
with fundamental molecular properties.
In additicn to the study and potential purification of
hydrocarbons by gas chromatography, the writer plans to investi-
gate another new technique for purification. This technique
involves the process of zone refining. The technique involves
the principal of purification by repeated freezing and melting.
The instrument is available and is appropriate for most compour.~s
melting between 50 and 300°C. Because of the automatic nature cf
this device, it presents an attractive technique for purificaticn.
Rece.it Russian literature indicates the use oi' this technioue :ct
the purif:caticn of naphthalene.
II. As noted in the progress report, certain results have
been obtained for benz(a)anthracene. This prograc must be extende~y
to the remaining tetracyclic compounds and their alkyl substitLtec
derivatives. This is a complex problem because of the fact that
several of the electronic transitions overlap each other and a~so
because several vibrational progressions occur thresghout the
electronic transitions. Moreover, the effect of alkyl substi-
tution is varied and complicated. However, a better understa.^.d_n;
of these molecules is essential. The study will provide a clearer
knowledge of the number of electronic transitions and the effect
alkyl substitution on (1) positions of.excited states, (2) ~v
transition probabilities amcng single states as well as singlet
and trinlet states. In addition, such knowledge along with tza:t
presently knok-r:, will aid in ccnsideration of the results of t:e
electron capture investigation.
CONF7I)ENTIAl.: MINNESOTA
C T R 1904
TOBACCO LITIGATION
CTR t~~~ t~~.~'.'~'~0
)
.j
6. audp.t pIon: 4/1 /61 - 3/3 1/62
THlS DOCUMENT SUBJECT 70 AUG.
20, 1985 N0N-DISSEn1IN.4TI0N ORDER
IN ROGERS AND DUKE CASES.
asobri.s e'1. 7, c,P
j. Exp.ndobl. StrppGa I , MY)
t . r.rnwn.M Eqvipm.nr RC10
,t. o»++.od (rrf.t a~~*dt ) 90~_
cAlMr
Tobi Z7 -_ 7T_
7. AnKopof.d Dvrotion of work: two additional years
. e. FoaFitia and Sw1I Awlbbte-: Staff : Dr. A. Zlatkis of the University of Houston
will work directly w-iET us on the instrumentation phase. Dr. Zlatkis
has.been very active in the realm of gas-liquid chromatography and
is one of the leaders in the field. Facilities: absorption spectro-
photometer, 2 glass prism spectrograph-'s;2 monochromators and
necessary auxillary equipment. Also, infrared absorption spectrd-
photometer.
9. i.ddin«,otk.qvtn.nwm: The budget as given above assumes that the un-
expended funds as of 3/31/61 can be carried over to the succeed_np
year. (f jofo tt)
C
10. Additionol Informofion (Indudinp rsbtion of vror4 fo oth.r proj.ch and otfi.r sownc.s of wpp1Y):
.The author presently holds a grant for study of arematic hydrocarbcrs
from the Department of Health, Education & i'elfare. This is a
three year grant, terminating 3/31/62, obtained after the con-
clusion of a two year grant. The appropriations available are
primarily for spectral investigation of the hydrocarbons. Funds
are included for a full-time research assistant and students,
chemical compounds, expendable photographic and other supplies
and a low temperature absorption spectra attachmer.t.
The author has been responsible for the collection of some 130
different aromatic hydrocarbons. This includes five complete
methyl series and several partially ccmpleted ones.
n
I#-
CONFIDEN77AL: MINNESOTA
TOBACCO LITIGATION
V17 .N LN. 11 / -*)a
of rroj
C T R
w«n.a oBo.. M,. 4uNtvfion
C. F. McV inney,
1905
1~_z
~
a
Vice President & Buainess Manager
C~`~ ~~ ~~~~~.~~
,
Dr. *XPbWWV6*K1WxPdC*"" Rchewcd ; 4NEc
APPLICATION FOR RENEWAL OF RESEARCH'GKANT
ow., February 6, 1962
I----
Cphthtl7tce '
TOlACCO INDUSTRY RESEARCH COMMITTEE
2 S.g~ ~2
b/.xoT i n, C h M 150 EAST FORTY SECOND STREEI NFW YORK 17, N. Y.
= l) l'.Tacob5on A cI-iVdfed
t. NaR» oF Fnwniy.rot: Dr. Ralph S. Decker :
2 TeF., Associate Professor of Chemistry
C:ardioY a s c vlar, phatm r c c /09 y and ChenclSTrv,
3. MttinAion
& AtWrtu:
University of Houston
3801 Cullen Boulevard
Houston, Texas
THIS DOCUMENT SUBJECT TO AUG.
20, 1985 NONDISSEMINATION ORDER
IN ROGERS AND DUKE CASES.
.. Pro;.c, o< sub;.ci: An Investigation of the Spectral and Chromatographic
Characteristics of Aromatic Hydrocarbons.
,
it
S. ttiasil.d Pl.n of Proc.dur (Ua4 r.v.ra, side if addition.l sp.ca is r+quir.dJ. In essence, a
continuation
grant is requested. The program will continue to involve the two major efforts
as outlined in the original proposal; that is; a study of the electron capture
phenomenon and analysis of the hydrocarbon electronic absorption and emission
spectra. '
I. The hydrocarbons used in the spectral study and the electror.
capture study appear to be of high purity. However, because of the difficulty
of finding a proper stationary liquid phase and carrier for a gas chromatographic
study, no careful definitive study of putity has been carried out. With the
cooperation of Dr. Lovelock and others, it now appears that a good carrier and
stationary liquid phase having good separation characteristics for the hydro-
carbons and high temperature stability has been found. It is anticipated that
the study of the tetracylics may be cbmpleted by the end of the grant period;
however, if it is not, it will be continued as part of the effort of the next
grant period. In addition, mass spectrographic data should also be available
for additional cross checking. Of cburse, also the spectral data (particularly
the emission) gives a good indication of purity.
The principle effort will be directed toward a bettsr and further understand:-
of the electron capture process. The progress report indicates that it has beer
rnssible to obtain the electron absorption coefficients for quite a variety of
;amatic hydrocarbons (see preprint from Nature). The possible significances
are also described.
CONFIDF,NTIAL: MINNESOTA
TOF3ACCO LITIGATION
CTR 1906
CT~ ~~ 002232
'~..
~
TNIS DOCUMENT SUBJECT TC AUG.
20, 1485 NOt:-DISSEtINATlDK ORDER
-
IN ROGERS FJiD DUKE CASE&
Continuation of S. Detailed Plan of Procedure
In addition, the pr.ogress report n cites what is considered to be the
present concept of the significance the electron absorption coefficients
and'kfasl'relation to a furuamental of molecules. The previous propo-
sal indicated a correlation may exist between the'absorption coefficients and
the relative energies of the first excited state which indeed seems to be the
case. However, further effort needs to be extended to assure the fact that
equilibrium is establisGed. One approach to this is varying the time between
pulse applications (see progvess report and preprint from Nature concerning
cell operation). Also other fundamental data such as lifetimes of excited
states could correlate with electron absorption coefficients. Therefore,
the lifetime data neeq to be obtained. The equipment for such work has be-
come available recentlyand such a study will be carried out. Moreover, of sig-
nificant importance is the effect heteroatoms in the aromatic ring have upon
the electron absorption coefficient. This feature shall also be investigated.
The incorporated heteroatom of most interest from both the spectroscopic and *
biological viewpoints would seem to be nitrogen. 'l~s, these types of'molecules
will receive the earliest attention. ~e he -C
Certain theoretical implications are involved as indicated in the progress
report. A portion of our effort will include the further exploration and
ramifications of these implications, for example, electron affinities of
molecules.
As noted in the progress report, there appearl to be two major consequence.s
of electron capture; (a) formation of a negative ion and (b) a dissociation
of the molecule. Indeed, it does not seem reasonable to compare electrnn
absorption coefficients arising from these two processes since one does involve
the molecule and the other the molecule plus fragments. Since the details of
the mechanism in the dissociative process are obscure, it is not possible to
be very definitive. In any event, this comparative feature is a salient one
and tbe significances and ramifications of this factor will be considered
during the exploration.
II. The analysis of the electronic transitions in aromatic hydrocarbons
will continue. This effort will be directed toward determining the numberand
nature of the electronic transitions and the nature of the vibrational se-
quences within and between transitions. As indicated in the progress report,
a knowledge of the energy of the first excited state (energy of the first
electronic transition) was an important factor in better understanding and
correlating the electron capture process with a fundamental molecular parameter.
The vibrational analysis will continue.'This analysis will not only provide
information relative to the vibrations which are excited upon electronic ex-
citation but will also assist in the assignment of electronic tra.nsitions
within the total absorption spectra. Also, it may be possible that a vibra-
tional analysis of the fluorescence a-hd phosphorescence will allow the symmeLry
of the lowest triplet state to be assigned.
CONFIDENTIAL: MINNESOTA C T R 1907
TOBACCO LITIGATION
V' { {ti i SN 00f ...~.~3vb
