Council for Tobacco Research
Report of the Council for Tobacco Research-U.S.A., Inc. [St]
Abstract
MAR
Fields
- Depository Date
- 25 Sep 1995
- Master ID
- Ctrmn00000667-6967
- CTRMN000667-0808 Deposition of Robert F. Gertenbach [Deposition of Gertenbach in the Matter of Rogers]
- CTRMN000809-0827 Certificate of Incorporation of the Council for Tobacco Research - U.S.A., Inc. Under Section 402 of the Not-for-Profit Corporation Law [Details Definitions and Purposes for Forming A Not-for-Profit Corporation]
- CTRMN000828-0848 by-Laws of the Council for Tobacco Research - U.S.A., Inc. [Rules and Regulations for the Operation of the Council]
- CTRMN000849-0854 Application for Research Grant [A Blank Funding Request Form for Scientific Studies]
- CTRMN000855-0856 Statement of Policy Containing Conditions and Terms Under Which Project Grants Are Made [Stipulations for Receiving A Funding Award]
- CTRMN000857-0859 [Suggestions and Guidelines for Submitting A Request for A Grant]
- CTRMN000860-0871 [Transmittal of Information for Securing A Research Grant]
- CTRMN000872-0882 [A Blank Funding Request Form for Scientific Studies]
- CTRMN000883-0892 Closing Dates for Application of Renewal Grants Requirements: (1) Progress Report and (2) Abstract of Progress Report [Procedural Information for Applying for Continued Funding for Scientific Project]
- CTRMN000893-1031 Published Reports on Research Supported in Whole or in Part by the Council for Tobacco Research - U.S.A. Formerly the Tobacco Industry Research Committee [List of Scientific Studies]
- CTRMN001032-1045 1956 Report of the Scientific Director [St]
- CTRMN001046-1094 1957 Report of the Scientific Director [St]
- CTRMN001095-1127 1958 Report of the Scientific Director [St]
- CTRMN001128-1163 1959 Report of the Scientific Director [St]
- CTRMN001164-1201 1960 Report of the Scientific Director [St]
- CTRMN001202-1239 1961 Report of the Scientific Director [St]
- CTRMN001240-1269 1962 Report of the Scientific Director [St]
- CTRMN001270-1306 Annual Report of the Scientific Director [St]
- CTRMN001307-1346 Report of the Scientific Director [St]
- CTRMN001347-1387 Report of the Scientific Director [St]
- CTRMN001388-1429 Report of the Scientific Director [St]
- CTRMN001430-1485 Annual Report of the Scientific Director [St]
- CTRMN001486-1529 Report of the Scientific Director [St]
- CTRMN001530-1578 Annual Report of the Council for Tobacco Research-U.S.A., Inc. [St]
- CTRMN001579-1632 Report of the Council for Tobacco Research-U.S.A., Inc. [St]
- CTRMN001633-1681 Report of the Council for Tobacco Research-U.S.A., Inc. [St]
- CTRMN001682-1727 Report of the Council for Tobacco Research-U.S.A., Inc. [St]
- CTRMN001728-1771 1975 Report of the Council for Tobacco Research-U.S.A., Inc. [St]
- CTRMN001772-1816 Report of the Council for Tobacco Research-U.S.A., Inc. [St]
- CTRMN001817-1860 1977 Report of the Council for Tobacco Research-U.S.A., Inc. [St]
- CTRMN001861-1913 Report of the Council for Tobacco Research-U.S.A., Inc. [St]
- CTRMN001914-1967 1979 Report of the Council for Tobacco Research-U.S.A., Inc. [St]
- CTRMN001968-2025 1980 Report of the Council for Tobacco Research-U.S.A., Inc. [St]
- CTRMN002026-2088 Report of the Council for Tobacco Research-U.S.A., Inc. [St]
- CTRMN002089-2148 Report of the Council for Tobacco Research-U.S.A., Inc. [St]
- CTRMN002224-2942 Application for Research Grant An Investigation of the Spectral and Chromatographic Characteristics of Aromatic Hydrocarbons. [Study on High Temperature Gas-Liquid Partition Chromatography]
- CTRMN002943-3303 [Regarding Polio and Tuberculosis As Predisposing Factor in Lung Cancer]
- CTRMN003304-3322 Tobacco-Health Research Program [Display Case Showing Main Areas of Investigation]
- CTRMN003323-3326 Statement of Policy Containing Conditions and Terms Under Which Project Grants Are Made [Rules for Approval of Grants Relating to Tobacco Use and Human Health]
- CTRMN003327-3337 A Brief Review of the Smoking-Lung Cancer Theory [Concerning Problems of Cigarette Lung Cancer Causation and Why They Have No Been Solved]
- CTRMN003338-3357 A Scientific Perspective on the Cigarette Controversy [Views of Cancer Experts on Causes of Lung Cancer]
- CTRMN003358-3365 Some Information About... The Council for Tobacco Research-U.S.A., Inc. ...and Its Research Program [Informs About the Purpose and Function of Organization's Research Program]
- CTRMN003366-3374 the Research Program of the Scientific Advisory Board to the Council for Tobacco Research - U.S.A. [Informs the Purposes, Policies, and the Research Program of the Board]
- CTRMN003375-3419 the Cancer-Smoking Controversy [Regards the Fallacious Conclusions of Cigarette Smoking Causing Lung Cancer From A Mathematical and Scientific Point of View]
- CTRMN003420-3425 Some Harvard Men & the Smoking Habit [Give Results of Questionnaire Relating to Biological Factors of Tobacco Smoking]
- CTRMN003426-3431 the Pathologic Anatomy of the Bronchial Tree and Lungs Reprinted From the Archives of Pathology Vol. 70 [St Finds of Equivocal Results with the Use of Tobacco]
- CTRMN003432-3437 Some Statistical Observations on A Co-Operative Study of Human Pulmonary Pathology Reprinted From the Proceedings of the National Academy of Sciences Vol. 43 No. 12 [St Examines Systematically the Conditions at Autopsy in the Bronchial Mucosae of Random Cases]
- CTRMN003438-3442 Some Statistical Observations on A Cooperative Study of Human Pulmonary Pathology, II [Results Show Pathological Lungs in Different Cities Are Acutally Different]
- CTRMN003443-3447 Some Statistical Observations on A Cooperative Study of Human Pulmonary Pathology. II [Study Comparing Pathological Conditions in 8 Different Cities Shows That Conditions Are All Different]
- CTRMN003448-3456 Some Statistical Observations on A Cooperative Study of Human Pulmonary Pathology [Systematic Examinations of the Conditions at Autopsy in the Bronchial Mucosae of Run-of-the-Mill Cases]
- CTRMN003457-3464 Some Statistical Observations on A Cooperative Study of Human Pulmonary Pathology III [When Probability Is Doubtful the Use of Variable Tables to Calculate Results Is the Best Way to Make A Precise and Accurate Answer for Sufficient Range of Pathological Conditions]
- CTRMN003465-3476 Differences Between Smokers and Nonsmokers [Differences Between Smokers and Nonsmokers Have to Do with Personality Traits and Physiologic Criteria]
- CTRMN003477-3485 the Psychology of Smoking [Smoking Is Determined by Certain Personality Variables and Personal Needs]
- CTRMN003486-3490 the Tobacco and Health Research Program of the Scientific Advisory Board [Regarding Information the Tobacco Industry Research Committee Do for the Research Program]
- CTRMN003491-3558 Tobacco Consumption in Various Countries [Results of Cigarette and Cigar Smokers From Different Countries]
- CTRMN003559-3560 Statement of Policy Containing Conditions and Terms Under Which Project Grants Are Made [Guidelines for Which Grants Are Approved]
- CTRMN003561-3780 Tobacco Smoking in the United States in Relation to Income Marketing Research Report No. 189 [A Report Compiled by the Bureau of the Census for the United States Public Health Service on Smoking Characteristics in Relation to Income, Age, Region, Urban-Rural Residence and Occupation.]
- CTRMN003781-3781 Operating Results 1982 and Budget 1983 [Record of Expenditures]
- CTRMN003782-3782 Operating Results for Ten-Months Ended 10/31 Budget 11/1/83 Through 10/31/84 [Record of Expenditures]
- CTRMN003783-3783 Actual Operating Fiscal Year 1984 and Budget Fiscal Year 1985 [Record of Expenditures]
- CTRMN003784-3787 Confidential Report on Meeting January 18, 1954 Tobacco Industry Research Committee (TIRC) [St]
- CTRMN003788-3797 Confidential Report on Meeting March 15, 1954 Tobacco Industry Research Committee [St]
- CTRMN003798-3800 Tobacco Industry Research Committee Meeting [St]
- CTRMN003801-3815 Tobacco Industry Research Committee Meeting [St]
- CTRMN003816-3835 Tobacco Industry Research Committee Meeting [St]
- CTRMN003836-3852 Tobacco Industry Research Committee Meeting November 3, 1955 [St]
- CTRMN003853-3869 Tobacco Industry Research Committee Meeting February 14, 1956 [St]
- CTRMN003870-3895 Tobacco Industry Research Committee Meeting October 9, 1956 [St]
- CTRMN003896-3907 Tobacco Industry Research Committee Meeting May 9, 1957 [St]
- CTRMN003908-3923 Tobacco Industry Research Committee Meeting November 8, 1957 [St]
- CTRMN003924-3931 Tobacco Industry Research Committee Meeting May 8 1958 [St]
- CTRMN003932-3939 Tobacco Industry Research Committee Meeting November 6, 1958 [St]
- CTRMN003940-3945 Tobacco Industry Research Committee Meeting [St]
- CTRMN003946-3956 Tobacco Industry Research Committee Meeting December 10, 1959 [St]
- CTRMN003957-3969 Tobacco Industry Research Committee Meeting November 15, 1960 [St]
- CTRMN003970-3982 Tobacco Industry Research Committee Meeting October 18, 1961 [St]
- CTRMN003983-3991 Tobacco Industry Research Committee Meeting [St]
- CTRMN003992-4002 Tobacco Industry Research Committee Meeting November 15, 1962 [St]
- CTRMN004003-4006 the Council for Tobacco Research - U.S.A. March 5, 1964 [St]
- CTRMN004007-4014 the Council for Tobacco Research - U.S.A. June 8, 1965 [St]
- CTRMN004015-4020 the Council for Tobacco Research - U.S.A. January 27, 1967 [St]
- CTRMN004021-4026 the Council for Tobacco Research - U.S.A. January 24, 1968 [St]
- CTRMN004027-4034 the Council for Tobacco Research - U.S.A. January 31, 1969 [St]
- CTRMN004035-4041 Minutes of the First Meeting of the Board of Directors [St]
- CTRMN004042-4048 Minutes of the Second Meeting of the Board of Directors January 29, 1971 [St]
- CTRMN004049-4052 Minutes of the Meeting of the Executive Committee of the Board of Directors June 24, 1971 [St]
- CTRMN004053-4057 Minutes of of the Board of Directors January 28, 1972 [St]
- CTRMN004058-4061 Minutes of the Meeting of the Board of Directors November 10, 1972 [St]
- CTRMN004062-4066 Minutes of the Meeting of the Board of Directors January 26, 1973 [St]
- CTRMN004067-4070 Minutes of the Special Meeting of the Board of Directors July 26, 1973 [St]
- CTRMN004071-4076 Minutes of the Meeting of the Board of Directors February 1, 1974 [St]
- CTRMN004077-4081 Minutes of the Special Meeting of the Board of Directors June 13, 1974 [St]
- CTRMN004082-4086 Minutes of the Special Meeting of the Board of Directors December 5, 1974 [St]
- CTRMN004087-4091 Minutes of the Meeting of the Board of Directors January 31, 1975 [St]
- CTRMN004092-4095 Minutes of the Special Meeting of the Board of Directors July 24, 1975 [St]
- CTRMN004096-4141 Retirement Plan for Employees of the Council for Tobacco Research - U.S.A., Inc. Amended and Restated As of July 1, 1975 [St]
- CTRMN004142-4147 Minutes of the Special Meeting of the Board of Directors December 10, 1975 [St]
- CTRMN004148-4153 Minutes of the Meeting of the Board of Directors January 30, 1976 [St]
- CTRMN004154-4157 Minutes of the Special Meeting of the Board of Directors September 9, 1976 [St]
- CTRMN004158-4161 Minutes of the Meeting of the Board of Directors January 28 1977 [St]
- CTRMN004162-4166 Minutes of the Special Meeting of the Board of Directors April 21 1978 [St]
- CTRMN004167-4167 Minutes of the Special Meeting of the Executive Committee of the Board of Directors August 17, 1978 [St]
- CTRMN004168-4172 Minutes of the Meeting of the Board of Directors January 29, 1979 [St]
- CTRMN004173-4176 Minutes of the Meeting of the Board of Directors February 1, 1980 [St]
- CTRMN004177-4178 Minutes of the Board of Directors Executive Committee Meeting New York, New York [St]
- CTRMN004179-4184 Minutes of the Meeting of the Directors January 30, 1981 [St]
- CTRMN004185-4189 Minutes of the Special Meeting of the Board of Directors June 25, 1981 [St]
- CTRMN004190-4192 Minutes of A Meeting of Certain Members of the Board of Directors [St]
- CTRMN004193-4198 Minutes of the Meeting of the Board of Directors [St]
- CTRMN004199-4205 Minutes of the Meeting of the Board of Directors [St]
- CTRMN004206-4209 Minutes of the Meeting of the Board of Directors [St]
- CTRMN004210-4213 Minutes of the Special Meeting of the Board of Directors [St]
- CTRMN004214-4217 Confidential Report of Scientific Advisory Board Meeting [St]
- CTRMN004218-4221 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004222-4226 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004227-4232 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004233-4236 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004237-4240 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004241-4246 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004247-4251 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004252-4256 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004257-4266 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004267-4283 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004284-4287 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004288-4292 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004293-4297 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004298-4303 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004304-4310 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004311-4316 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004317-4319 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004320-4323 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004324-4330 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004331-4335 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004336-4339 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004340-4344 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004345-4348 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004349-4353 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004354-4357 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004358-4366 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004367-4370 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004371-4376 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004377-4390 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004391-4395 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004396-4400 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004401-4404 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004405-4409 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004410-4413 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004414-4416 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004417-4420 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004421-4426 Confidential Report Scientific Board Meeting [St]
- CTRMN004427-4430 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004431-4433 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004434-4436 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004437-4439 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004440-4443 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004444-4446 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004447-4450 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004451-4454 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004455-4459 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004460-4463 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004464-4467 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004468-4472 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004473-4475 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004476-4480 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004481-4484 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004485-4492 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004493-4497 Confidential Report Scientific Advisory Board Meeting September 23-24, 1967 [St]
- CTRMN004498-4501 Confidential Report Scientific Advisory Board Meeting December 9-10, 1967 [St]
- CTRMN004502-4505 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004506-4510 Confidential Report Scientific Advisory Board Meeting La Jolla, California March 2-3-4, 1968 [St]
- CTRMN004511-4516 Confidential Report Scientific Advisory Board Meeting New York New York May 25-26, 1968 [St]
- CTRMN004517-4522 Confidential Report Scientific Advisory Board Meeting New York, New York September 14-15, 1968 [St]
- CTRMN004523-4526 Confidential Report Scientific Advisory Board Meeting New York, New York December 8-9, 1968 [St]
- CTRMN004527-4531 Confidential Report Scientific Advisory Board Meeting New York, New York March 22-23, 1969 [St]
- CTRMN004532-4538 Confidential Report Scientific Advisory Board Meeting New York, New York May 16-18, 1969 [St]
- CTRMN004539-4544 Confidential Report Scientific Advisory Board Meeting New York, New York September 12-14, 1969 [St]
- CTRMN004545-4549 Confidential Report Scientific Advisory Board Meeting New York, New York December 12-14, 1969 [St]
- CTRMN004550-4555 Confidential Report Scientific Advisory Board Meeting Colorado Springs, Colorado March 20-22, 1970 [St]
- CTRMN004556-4560 Confidential Report Scientific Advisory Board Meeting New York, New York [St]
- CTRMN004561-4569 Confidential Report Scientific Advisory Board Meeting New York, N.Y. September 18-19-20, 1970 [St]
- CTRMN004570-4578 Confidential Report Scientific Advisory Board Meeting Chicago, Illinois January 15,16, 1971 [St]
- CTRMN004579-4585 Confidential Report Scientific Advisory Board Meeting New York, N.Y. May 7-8-9, 1971 [St]
- CTRMN004586-4593 Confidential Report Scientific Advisory Board Meeting New York, N.Y. September 24-25-26, 1971 [St]
- CTRMN004594-4598 Confidential Report Scientific Advisory Board Meeting New York, N.Y. [St]
- CTRMN004599-4604 Confidential Report Scientific Advisory Board Meeting Palm Springs, California March 24-25-26, 1972 [St]
- CTRMN004605-4609 Confidential Report Scientific Advisory Board Meeting New York, New York June 9-11, 1972 [St]
- CTRMN004610-4614 Confidential Report Scientific Advisory Board Meeting New York, New York September 15-17, 1972 [St]
- CTRMN004615-4623 Confidential Report Scientific Advisory Board Meeting New York, New York March 14-15-16, 1973 [St]
- CTRMN004624-4626 Meeting Executive Committee of the Scientific Advisory Board June 13, 1973 New York, N.Y. [St]
- CTRMN004627-4634 Confidential Report Scientific Advisory Board Meeting New York, New York October 10-11-12, 1973 [St]
- CTRMN004635-4643 Meeting Executive Committee of the Scientific Advisory Board December 4, 1973 New York, N.Y. [St]
- CTRMN004644-4654 Confidential Report Scientific Advisory Board Meeting New York, New York October 30-31 November 1, 1974 [St]
- CTRMN004655-4656 Meeting Executive Committee of the Scientific Advisory Board December 13, 1974 New York, N.Y. [St]
- CTRMN004657-4664 Confidential Report Scientific Advisory Board Meeting Santa Barbara, California March 26-27-28, 1975 [St]
- CTRMN004665-4672 Confidential Report Scientific Advisory Board Meeting New York, New York September 10-11-12, 1975 [St]
- CTRMN004673-4675 Meeting Executive Committee of the Scientific Advisory Board New York, New York December 13, 1975 [St]
- CTRMN004676-4683 Confidential Report Scientific Advisory Board Meeting Santa Barbara, California March 17-18-19, 1976 [St]
- CTRMN004684-4686 Meeting of the Executive Committee of the Scientific Advisory Board New York, New York June 11, 1976 [St]
- CTRMN004687-4694 Confidential Report Scientific Advisory Board Meeting New York, New York September 28-29-30, 1976 October 1, 1976 [St]
- CTRMN004695-4697 Meeting of the Executive Committee of the Scientific Advisory Board Bethesda, Maryland December 1, 1976 [St]
- CTRMN004698-4706 Confidential Report Scientific Advisory Board Meeting Tuscon, Arizona March 23-25, 1977 [St]
- CTRMN004707-4708 Meeting of the Executive Committee of the Scientific Advisory Board Tuscon, Arizona March 25, 1977 [St]
- CTRMN004709-4710 Meeting of the Executive Committee of the Scientific Advisory Board New York, New York May 19, 1977 [St]
- CTRMN004711-4719 Confidential Report Scientific Advisory Board Meeting New York, New York October 26-28, 1977 [St]
- CTRMN004720-4723 Confidential Report Scientific Advisory Board Meeting Phoenix, Arizona January 16-17, 1978 [St]
- CTRMN004724-4724 Confidential Report Meeting of the Scientific Advisory Board Committee Phoenix, Arizona January 17, 1978 [St]
- CTRMN004725-4734 Confidential Report Scientific Advisory Board Meeting New York, New York April 26-27-28, 1978 [St]
- CTRMN004735-4735 Confidential Report Scientific Advisory Board Executive Committee New York, New York April 27, 1978 [St]
- CTRMN004736-4737 Confidential Report Meeting for the Scientific Advisory Board New York, New York July 27, 1978 [St]
- CTRMN004736A-4736A Confidential Report Meeting of the Scientific Advisory Board New York, New York July 27, 1978 [St]
- CTRMN004738-4747 Confidential Report Scientific Advisory Board Meeting New York, New York October 18-19-20, 1978 [St]
- CTRMN004748-4750 Confidential Report Meeting of the Scientific Advisory Board New York, New York December 20, 1978 [St]
- CTRMN004751-4759 Confidential Report Scientific Advisory Board Meeting New York, New York April 11-12-13, 1979 [St]
- CTRMN004760-4769 Confidential Report Scientific Advisory Board Meeting New York, New York October 17-18-19, 1979 [St]
- CTRMN004770-4770 Confidential Meeting of the Report Scientific Advisory Board New York, New York October 18, 1979 [St]
- CTRMN004771-4780 Confidential Report Scientific Advisory Meeting New York, New York Aprill 9-10-11, 1980 [St]
- CTRMN004781-4781 Confidential Report Executive Committee of the Scientific Advisory Board Meeting New York, New York June 20, 1980 [St]
- CTRMN004782-4783 Confidential Report Executive Committee of the Scientific Advisory Board Meeting New York, New York September 16, 1980 [St]
- CTRMN004784-4792 Confidential Report Scientific Advisory Board Meeting New York, New York October 8-9-10, 1980 [St]
- CTRMN004793-4794 Confidential Report Meeting of the Scientific Advisory Board New York, New York October 9, 1980 [St]
- CTRMN004795-4804 Confidential Report Scientific Advisory Board Meeting New York, New York April 8-9-10, 1981 [St]
- CTRMN004805-4805 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board New York, New York April 8, 1981 [St]
- CTRMN004806-4806 Confidential Report Meeting of the Scientific Advisory Board New York, New York September 10, 1981 [St]
- CTRMN004807-4816 Confidential Report Scientific Advisory Board Meeting New York, New York October 14-15-16, 1981 [St]
- CTRMN004817-4818 Confidential Report Meeting of the Executive Committee Scientific Advisory Board New York, New York October 15, 1981 [St]
- CTRMN004819-4820 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board New York, New York December 9, 1981 [St]
- CTRMN004821-4831 Confidential Report Scientific Advisory Board Meeting New York, New York April 21, 22, 23, 1982 [St]
- CTRMN004832-4833 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board New York, New York June 21, 1982 [St]
- CTRMN004834-4843 Confidential Report Scientific Advisory Board Meeting New York, New York October 6,7,8, 1982 [St]
- CTRMN004844-4844 Confidential Report Meeting of the Executive Meeting of the Scientific Advisory Board New York, New York October 8, 1982 [St]
- CTRMN004845-4845 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board Scottsdale, Arizona February 24, 1983 [St]
- CTRMN004846-4857 Confidential Report Scientific Advisory Board Meeting New York, New York April 20, 21, 22, 1983 [St]
- CTRMN004858-4858 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board New York, New York April 22, 1983 [St]
- CTRMN004859-4859 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board New York, New York June 6, 1983 [St]
- CTRMN004860-4871 Confidential Report Scientific Advisory Board Meeting New York, New York October 12, 13, 14, 1983 [St]
- CTRMN004872-4882 Confidential Report Scientific Advisory Board Meeting New York, New York March 28, 29, 30, 1984 [St]
- CTRMN004883-4883 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board New York, New York March 29, 1984 [St]
- CTRMN004884-4895 Confidential Report Scientific Advisory Board Meeting September 19, 20, 21, 1984 New York, New York [St]
- CTRMN004896-4896 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board New York, New York September 20, 1984 [St]
- CTRMN004897-4897 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board Palm Beach, Florida February 25, 1985 [St]
- CTRMN004898-4898 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board New York, New York April 16, 1985 [St]
- CTRMN004899-4910 Confidential Report Scientific Advisory Board Meeting April 15, 16, 17, 1985 New York, New York [St]
- CTRMN004911-4911 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board New York, New York April 16, 1985 [St]
- CTRMN004912-4923 Confidential Report Scientific Advisory Board Meeting April 15, 16, 17, 1985 New York, New York [St]
- CTRMN004924-4927 for Release: A.M.'s Wednesday, April 14, 1954 ["Reaction to the Compendium "A Scientific Perspective on the Cigarette Controversy""]
- CTRMN004928-4929 for Release: A.M.'s Tuesday, April 27, 1954 [Scientific Advisory Board Organized Early to Begin Research Into All Phases of Tobacco Use and Health for the Year]
- CTRMN004930-4931 for Release in A.M.'s of Tuesday, May 18, 1954 [Proposals Submitted for Cancer Research Projects for Consideration by Scientific Advisory Board]
- CTRMN004932-4933 for Release After 10:30 A.M., June 15, 1954 [Appointment of Dr. Clarence Cook Little Announced by the Tobacco Research Industry Committee]
- CTRMN004934-4937 for Immediate Release [American Cancer Society Survey Conveys the Need to Further Research to Discover Cause of Cancer and Cardiovascular Disease]
- CTRMN004938-4939 for Release in Am's of Tuesday, July 20, 1954 [Edwin B. Wilson of Harvard University Became A Member of Scientific Advisory Board of the Tobacco Industry Research Committee]
- CTRMN004940-4942 for Release: A.M.'s of Wednesday, July 28, 1954 Little Announces Research Policy of Tobacco Industry Research Committee [Three Main Areas to Be Covered by Research Program Announced]
- CTRMN004943-4944 for Release in A.M.'s Thursday, August 19, 1954 [Dr. Julius H. Comroe of University of Pennsylvania, Accepted Membership on Scientific Advisory Board of the Tobacco Industry Research Committee]
- CTRMN004945-4945 for Immediate Release (Monday, October 11, 1954) Dr. Little Gives TIRC View [Little States That No Convincing Evidence Has Yet Been Found to Prove That Cigarette Smoking Causes Lung Cancer]
- CTRMN004946-4946 for Immediate Release (Tuesday, October 12, 1954) [Timothy V. Hartnet, Chairman of Board, Stated That Public Should Be Reminded That No Lung Cancer Causing Agent Has Yet Been Identified in Tobacco]
- CTRMN004947-4947 for Release: Wednesday, October 20, 1954 Hartnett Approves Care in Research [Committee to Be Sure That Reliable Evidence Is Available Before Announcing Important Conclusions to the Public About Smoking]
- CTRMN004948-4948 for Immediate Release (Thursday, October 21, 1954) Hartnett Comments on Cigarette Paper Burning [Timothy V. Hartnett Comments That A Cancer Causing Compound on Skin of Mice Has Been Produced by Burning Cigarette Paper Under Certain Lab Conditions]
- CTRMN004949-4952 for Release: A.M.'s, Monday, November 8, 1954 Tobacco Industry Research Committee Announces Initial Grants [Six Scientific Research Grants Totalling Over $82,000 Made Public]
- CTRMN004953-4954 for Release in A.M.'s, Monday, December 6, 1954 Scientific Associate Named by Tobacco Research Group [Robert C. Hockett Appointed As Scientific Director of TIRC to Help Develop Research Into Tobacco Use and Health]
- CTRMN004955-4956 for Immediate Release Cross-Country Lung Study Planned by Tobacco Group [Group of Pathologists Plan A Cooperative Study to Increase Knowledge of Lung Ailments]
- CTRMN004957-4959 for Release in Year-End Editions But Not Before December 27, 1954 Statement by Timothy V. Hartnett, Chairman Tobacco Industry Research Committee [TIRC Will Approve A Quarter of A Million Dollars for Research Into Public Health Problems by the End of 1954]
- CTRMN004960-4963 for Release: Monday A.M.'s, January 17, 1955 Tobacco Industry's New Research Grants Send Total to More Than $300,000 [New Research Grants Announced by TIRC to Relate to Both Human and Animal Scientific Studies]
- CTRMN004964-4966 for Release in A.M.'s of Friday, April 8, 1955 Tobacco Industry Group Votes Medical Research Fellowships [TIRC Announced Fellowship Program to Create Interest in Research Among Medical School Students]
- CTRMN004967-4969 Release Tuesday, May 17, 1955 and Thereafter Tobacco and Health Studies Cover Wide Range of Research [Although No Scientific Proof That Cigarettes or Air Pollution Cause Lung Cancer, Progress Is Being Made to Learn More About Tobacco Use and Health by the TIRC]
- CTRMN004970-4972 Tobacco Research Grants Increased to 490,000 Mark [Research Grants Are Created So Science Can Provide An Answer to Public Health Problems]
- CTRMN004973-4973 Hartnett Comments on Auerbach Paper [Many Studies on Human Lung Tissue, Not Enough Data Available to Draw A Conclusion Yet]
- CTRMN004974-4975 Anti-Smoking Theories Not Based on Complete Scientific Knowledge [Scientific Investigation Into What the Real Effects Are From Tobacco Use]
- CTRMN004976-4977 Hartnett Comments on Statistical Study [Research Intensified in Past Year, No Proof That Smoking Causes Cancer]
- CTRMN004978-4980 Doctor's Survey Termed 'biased, 'says Hartnett [Questionnaire Would Give No Concrete Conclusions About Tobacco Causing Cancer]
- CTRMN004981-4982 Hartnett Alerts Burley Men to Challenge Tobacco Attacks [Doctors Are Expressing Their Doubts About Statements Already Made; Tobacco Effects]
- CTRMN004983-4984 Bright Belt Warehouse Men Told Facts Challenge Critics [Still Looking for Proof That Tobacco Causes Cancer]
- CTRMN004985-4986 Tobacco Spokesman Says Facts and Position Are Unchanged [Various Experiments with Animals Showed That Cancer Was Not the Outcome From Tobacco Smoke]
- CTRMN004987-4987 Hartnett Comments on Statistical Study [Methods Used for Cancer Research Still Do Not Give Enough Information]
- CTRMN004988-4990 British Tobacco Experiments Unable to Induce Cancers [Still No Connection, Tests Will Continue]
- CTRMN004991-4993 Tobacco Research Grants Now Over 838,000 Mark [Tobacco Research Is Getting More Support From Doctors, Scientists, and Educators]
- CTRMN004994-4996 Statement by Timothy V. Hartnett, Chairman Tobacco Industry Research Committee [Summary of the Past Years' Events in Tobacco Research]
- CTRMN004997-4999 Tobacco Research Fund Raised to 1,500,000 [Finding New Ways to Break Down Tobacco]
- CTRMN005000-5001 Tobacco Industry Group Renews Medical Research Fellowships [More Medical Students Are Receiving Fellowships Than Last Year]
- CTRMN005002-5003 Hartnett Statement on Cancer Meeting Reports [There Is Still Much Research to Be Done Before Tobacco Is Linked to Cancer]
- CTRMN005004-5005 [Pathologists From Around the Country Have Studied Human Lung Tissues Over the Past Year]
- CTRMN005006-5006 [Smoking Patterns Do Not Explain Differences in Lung Cancer]
- CTRMN005007-5008 Hartnett Cites British Tobacco Tests Failing to Produce Animal Cancer [the Search for Cancer Must Be Broadened and Intensified]
- CTRMN005009-5010 Hartnett Comments on Statistical Claims [Although Many Believe Smoking Causes Cancer, Scientists Still Have Not Found Any Prof]
- CTRMN005011-5011 [Present Knowledge Doesn't Hint A Relationship Between Smoking and Heart Problems]
- CTRMN005012-5016 Hartnett Comments on Cancer Society Booklet [Pamphlet Omits Some Important Research Results]
- CTRMN005017-5018 Statement by Timothy V. Hartnett, Chairman Tobacco Industry Research Committee [Research Committee Needs More Scientific Investigation]
- CTRMN005019-5025 Tobacco Research Funds Reach 2.2 Million Mark [Over 60 Independent Scientists Throughout the Country Are Working in Institutions to Further the Research of Cancer and Tobacco Use, They Are Listed]
- CTRMN005026-5027 Hartnett Comments on French Report [French Are Reporting Rapid Cancer Formation in Mice, Hartnett Feels It Can't Be Judged on the Basis of New Reports Without Longer Consideration and Careful Analysis]
- CTRMN005028-5030 Harnett Cites Points for Clarification in Tobacco Health Study [Smoking Study Reached the Public's Attention Before It Was Reviewed and Before the Facts Were Made Crystal Clear]
- CTRMN005031-5032 Hartnett Comments on Wynder News Stories [News Story Claims That Assumptions Have Been Made About Mouse Skin Painting Experiments]
- CTRMN005033-5037 Statement on Smoking and Health Studies [Scientists Are Developing A Program for Different Phases of Tobacco Use and Health, Members Listed]
- CTRMN005038-5045 Hartnett Says Statistics Do Not Establish Causes [Studies Are Open to Assumptions and Certain Selection of Subjects]
- CTRMN005046-5048 Hartnett Cites Scientists Doubting Smoking-Cancer Theory [the Surgeon General Believes the Studies Are Missing Essential Facts That Should Be Acknowledged]
- CTRMN005049-5050 Scientist Comments on Benzpyrene Report [Benzpyrane in Tobacco Smoke, Under Investigation for Years Caused Cancer in Lab Animals But Not Humans]
- CTRMN005051-5055 "Cancer Researcher Challenges "Cause and Effect" Charges Against Smoking" [It's Difficult to Have A Cause and Effect Relationship When Dealing with Cancer and Tobacco Use]
- CTRMN005056-5056 [Atlantic Monthly Gives A Misleading Picture of Dr. Little and His Public Position]
- CTRMN005057-5058 Tobacco Committee Chairman Comments on Cancer Society Talk [Many Unresolved Questions About Tobacco Causing Cancer Don't Stop Researching]
- CTRMN005059-5061 Tobacco Research Scientist Discusses Smoking Question [Most Tend to Believe the Anti-Cigarette Theory But It Shouldn't Be Confused with the Facts There's Still Not Enough Facts to Prove That Smoking Causes Cancer]
- CTRMN005062-5062 Hartnett Says Leaflet Admits Differing Opinions on Smoking [Leaflet Tells How Scientists Disagree on Evidence]
- CTRMN005063-5066 Research Program Throws Doubts on Smoking Charges [Incorrect Claims and Harmful Effects From Tobacco]
- CTRMN005067-5069 Statement by Timothy V. Hartnett, Chairman Tobacco Industry Research Committee [More and More Scientists Had Doubts and Disbeliefs in the Charges Against Smoking As A Cause of Cancer]
- CTRMN005070-5071 Tobacco Research Scientist Discusses Smoking Question [Scientists Say Smoking Has Been Proved Guilty When Linked with Human Health Problems]
- CTRMN005072-5072 Pamphlet Merely Review, Dr. Little Says [Opinions Is All the Author Gives in His Pamphlet Scientists Are Still Disputing]
- CTRMN005073-5076 TIRC Fund for Research Boosted to $2,700,000 [Grants for Independent Scientists Interested in Studying Problems of Cancer and Heart Disease When Related to Smoking]
- CTRMN005077-5080 [New Knowledge on Smoking and Health Questions]
- CTRMN005081-5081 [Veterans Study of Smoking Habits]
- CTRMN005082-5082 [Report on How There Was Existing Research Evidence and How It Was Ignored]
- CTRMN005083-5085 [Regarding Anti-Tobacco Movement]
- CTRMN005086-5086 [Benzpyrene in Cigarette Smoke]
- CTRMN005087-5088 [Experimental Evidence Is Weak]
- CTRMN005089-5089 Hartnett Says Article on Arsenic Goes Beyond Facts [Farmers Use of Insecticides with Arsenicals on Growing Tobacco Has Steadily Been Declining]
- CTRMN005090-5091 [Scientists Who Produce Conflicting Results Are Being Ignored by the Health Department]
- CTRMN005092-5094 Statement by Timothy V. Hartnett, Chairman Tobacco Industry Research Committee [Even More Grants Have Been Made Available More Factors Have Been Associated with Lung Cancer]
- CTRMN005095-5100 Tobacco Industry Group Announces Research Grants [Grant Increases to $3,200,000 List of Grants Announced]
- CTRMN005101-5103 Tobacco-Health Research Described in 1958 Report [the Report Talked About Experiments That Were Unable to Produce Cancer and the Cause and Effect Theory]
- CTRMN005104-5104 [Report Shows That Other Factors Besides Smoking Have Been Causing Lung Cancer, But Scientists Do Not Dismiss the Fact That Lung Cancer Is Possibility From Smoking]
- CTRMN005105-5105 [Anti-Smoking Campaign Is Thought to Be A One-Sided Propaganda Effort]
- CTRMN005106-5106 [Questions Arise From on-Sided Study]
- CTRMN005107-5111 Cancer Scientist's Comments on Smoking-Lung Cancer Review [Evidence on Smoking and Lung Cancer Is Accumulating, Among Other Contributing Factors]
- CTRMN005112-5117 [Comments Relating to Observation on Various Studies]
- CTRMN005118-5122 Research Grants Announced by Tobacco Industry Group [$500,000 Was Added to Research Funds, A List of Recipients with the New Grants Is Mentioned]
- CTRMN005123-5127 Research Supported by Tobacco Committee Discussed in Scientific Director's Report [It Seems That Finding An Answer to Lung Cancer and Cardiovascular Diseases Are Too Complicated]
- CTRMN005128-5128 [Attacks on Tobacco, the Lung Cancer Issue Is Still Not Settled]
- CTRMN005129-5129 Nta Stand on Smoking Repeats Opinions [Statement Gives No Evidence and Is Dealing Mainly with Opinions]
- CTRMN005130-5132 Tobacco Research Group Adds New Scientific Associate [New Scientific Director Was Added to the TIRC, Curriculum of J. Morrison Brady]
- CTRMN005133-5134 Tobacco Research Group Cites Questions Raised in Heart Statement [Lack of Evidence Proposes New Questions and Doubts About Cardiovascular Disease]
- CTRMN005135-5137 New Evidence Shows Complexities of Lung Cancer, Scientist Says [Hundreds of Studies Indicate Many Factors Contribute to the Complex Chain That May Result in Lung Cancer, No One Can Figure Out the Right Factor and Still the Reported Lung Cancer Cases Are Rising]
- CTRMN005138-5140 New Grants to Scientists Made by Tobacco Research Group [Research Grants Totalling $523,000 Made to 40 Scientists This Year]
- CTRMN005141-5144 Cancer Research Opens Up New Areas, Extra Funds Appropriated for Study [TIRC Stepping Up Financial Support of Independent Health Research]
- CTRMN005145-5147 Scientists in 11 States Get Research Grants for Tobacco-Health Studies [17 Research Grants Totaling Nearly $200,00 Awarded to Scientists in 11 States for Studies of Tobacco Use and Health]
- CTRMN005148-5151 New Direction for Tobacco-Health Research in '61, Says Chairman of Tobacco Industry Research Committee [Future Research to Concentrate on How Lung Cancer and Heart Disease Originate]
- CTRMN005152-5160 Research on Smoking and Health Discussed by Scientific Advisory Board to T.I.R.C. [Health Research Expansion Called for in 22 Specific Areas]
- CTRMN005161-5162 Scientist Reports on Research Progress As T.I.R.C. Boosts Funds to $4,650,000 [Dr. Clarence Cook Little Proposed Steps for Medical Research]
- CTRMN005163-5163 Nation's Medical Students Offered Research Fellowships by Tobacco Research Group [Program Designed to Encourage Research As A Career]
- CTRMN005164-5168 Scientists in 14 States Get Research Grants for Tobacco-Health Studies [Fifteen Grants for New Research Announced]
- CTRMN005169-5173 Tobacco Industry Research Committee Adds $800,000 for New Research [Emphasis Put on Viruses, Bioassay, Psychological and Physiological Research]
- CTRMN005174-5176 ""Significant Developments" in Cancer Research Reviewed in Annual Report by Dr. C.C. Little" [Scientific Findings of the Past Year Reviewed]
- CTRMN005177-5179 Tobacco Research Group Offers Fellowships to Medical Students to Spur Interest in Research Work [Program Designed to Encourage Career in Research]
- CTRMN005180-5180 Tobacco Research Committee Chairman Comments on Mouse Skin Painting [Harmless Everyday Substances Can Cause Cancer in Laboratory Animals]
- CTRMN005181-5182 Smoking-Health Situation Calls for Facts, Not Emotions, Says Hartnett [Repetition Does Not Add to Scientific Knowledge]
- CTRMN005183-5217 Smoking-Health Situation Calls for Facts, Not Emotions, Says Hartnett [Repetition Does Not Add to Scientific Knowledge]
- CTRMN005218-5224 52 Additional Research Grants Made by Tobacco Industry Group [Money for Studies Designed to Give New Leads to Lung Cancer and Other Health Problems]
- CTRMN005225-5225 Medical Student Fellowships Offered by Tobacco Research Group [Program to Encourage Research]
- CTRMN005226-5228 Gaps Still Exist in Knowledge of Lung Cancer and Heart Disease, Says Little [Multiple Factors and Influences That Contribute to Lung Cancer Unknown]
- CTRMN005229-5230 Scientific Director of Tobacco Industry Research Committee Comment on Resolution by American Heart Association [TIRC Welcomes Recognition of Need for Further Research to Determine Full Facts About Smoking]
- CTRMN005231-5234 Tobacco Committee Adds $1 Million for Continuing Research Studies [Scientific Advisory Board Assured TIRC Will Provide More Funds]
- CTRMN005235-5235 [Scientific Director of TIRC Sent Telegrams to the Surgeon General and the President of the Ama]
- CTRMN005236-5236 [Ama Supports Research on Tobacco and Health]
- CTRMN005237-5239 [TIRC Renamed and Reorganized]
- CTRMN005240-5241 Dr. Howard B. Andervont Named to the Scientific Advisory Board [Editor of the Journal of the National Cancer Institute Appointed]
- CTRMN005242-5277 Tobacco Industry Group Awards $817,165 for Health Research [37 Additional Research Grants Have Been Awarded by the Ctr]
- CTRMN005278-5282 Scientific Director C.C. Little Reports Decade of Tobacco-Health Research [Findings on What Diseases Smoking Can Cause]
- CTRMN005283-5286 Council Awards $500,000 for Tobacco and Health Research [Number of Grants Awarded for Tobacco Use and Health Research]
- CTRMN005287-5291 Summary of the Testimony of Clarence C. Little Before the Senate Commerce Committee [Discussion on Cancer and How It Affects Our Bodies]
- CTRMN005292-5319 Council Awards $514,767 for Tobacco and Health Research [Number of Grants Awarded to Scientist Over the Period of 10 Years]
- CTRMN005320-5348 Tobacco - Health Studies Reviewed in Annual Report [Discussion on Cigarette Smoking Being Helpful with Causing Diseases in Smokers]
- CTRMN005349-5367 Tobacco and Health Research Awards Pass $9 Million Total [Grants Given to Scientist Studying Matter Related to Tobacco Use and Health]
- CTRMN005368-5375 Tobacco-Health Research Grants Awarded New York Scientists [Scientists Approved to Continue Research on Lung Cancer and Other Diseases]
- CTRMN005376-5382 Tobacco - Health Studies Reviewed in Annual Report [Studies of the Respiratory System in Experimental Animals and Human Patients Especially on Causes of Pulmonary Cancers]
- CTRMN005383-5384 [Opinions of Scientists That There Is No Relationship Between Smoking and Disease]
- CTRMN005385-5387 New Tobacco-Health Research Grants Total $2 Million [Number of Approved Grants for Studies on Tobacco Use and Health]
- CTRMN005388-5388 Furst Becomes Consultant to Tobacco Research Council [Dr. Furst Advise to Council on Programs Sponsored by Them]
- CTRMN005389-5393 Studies Raise Questions About Smoking As Health Hazard [Numerous Studies Done to Show What Effect Smoking Had on Our Health]
- CTRMN005394-5400 Broad Review of Tobacco-Health Picture Covered in Dr. Little's Latest Report Lung Cancer, Heart Disease, Chronic Pulmonary Ailments Are Complex in Nature, Says Noted Researcher Genetic and Environmental Factors May Be Involved Reports Scientific Director of Council for Tobacco Research [Recent Research Finding on Lung Cancer, Heart Disease and Chronic Pulmonary Ailments]
- CTRMN005401-5404 Significant Smoking-Health Finding Covered in Report by Dr. C.C. Little [Findings From Independent Scientists on Smoking and Health]
- CTRMN005405-5408 New Tobacco-Health Grants Announced; One Helps Revive Framinghan Heart Study [Awards Granted to Independent Scientists Researching Tobacco and Health]
- CTRMN005409-5412 New Scientific Findings About Cancer, Heart Disease, the Lung, Other Areas, Reported by Council for Tobacco Research [New Findings From Independent Scientists Relating to Tobacco and Health Issue]
- CTRMN005413-5415 New Smoking-Health Studies Boost Total to $23-Million [Council Awards More Grants to the Study of Lung Cancer, Viruses and Cancer, Heart Disease, and Chronic Pulmonary Ailments]
- CTRMN005416-5418 Progress in Tobacco-Health Research Achieved: Machines That Simulate Human Smoking [Machines to Help Scientists Effectively Study Smoke and Health Issues]
- CTRMN005419-5421 Noted Cancer Scientist Named Scientific Director of the Council for Tobacco Research [Dr. Hockett Who Was Acting Scientific Director Got Promoted to Research Director]
- CTRMN005422-5425 Massive Cancer Study Using Made-to-Order Mice [Study Using Mice to See If Human Lung Cancer Can Be Induced Regularly]
- CTRMN005426-5427 Tobacco Research Group Announces New Studies [12 New Studies Have Been Funded to Study Generic Factors in Lung Cancer and Emphysema and the Possible Influence of Nicotine on Fetal Growth]
- CTRMN005428-5429 Studies of Twins Expanded by Tobacco Research Group [Human Twins Used for Study to Determine Effects of Environment Agents on Various Diseases]
- CTRMN005430-5432 News About Smoking and Health Study Interaction of Genetic and External Influences in Lung Cancer [Studies Show That Only Minority of Smokers Get Lung Cancer Therefore Lung Cancer May Be Caused by Genetic Characteristics or External Influences Which People Have Been Exposed]
- CTRMN005433-5434 New Smoking and Health Grants Made by Tobacco Research Council [New Studies Have Received Grants to Continue Researching on Smoking and Health]
- CTRMN005435-5435 Yeaman Assumes Leadership of Council for Tobacco Research [Addison Yeaman Succeeds H.H. Ramm for Chairman and President of the Council for Tobacco Research]
- CTRMN005436-5438 14 New Studies Funded by Tobacco Research Council [Grants Awarded to Studies for Inhibition of Cancer by Different Chemicals, the Influence of Nicotine on Pregnancy and the Effects of Cigarette Smoke on the Body's Disease Fighting System]
- CTRMN005439-5441 Progress Being Made in Research on Emphysema [Scientist Discover Ways to Help Defend Against Emphysema]
- CTRMN005442-5444 14 New Smoking-Health Projects Are Approved [Recent Research Studies Dealing with Smoking and Health Have Been Given Grants]
- CTRMN005445-5446 Grants Awarded for New Smiking-Health Studies [Scientists Were Approved for Studying of Certain Enzymes in Human Lung Cancer and Emphysema]
- CTRMN005447-5448 Tobacco Research Report Discusses Heart Disease [Studies Have Found Progressive Atherosclerosis Rank First As Number One As Causes of Death From Cardiovascular Disease]
- CTRMN005449-5451 Grants Awarded for New Smoking-Health Research [New Studies Have Been Approved for Marker Substance That May Indicate Presence of Lung Cancer and on Smoking and Pregnancy]
- CTRMN005452-5453 Tobacco Research Group Funds New Smoking-Health Projects [A New Study for Relationship of Childhood Respiratory Disease to the Development of Adult Chronic Lung Disease]
- CTRMN005454-5455 Tobacco Research Group Reports... Funds for Smoking-Health Studies Pass $46,000,000 [Amount Council Has Given to Scientist for Research]
- CTRMN005456-5458 $5.9 Millions Given for Smoking-Healths Studies [Council Has Given Millions Over the Years to Researchers]
- CTRMN005459-5460 Tobacco Research Group Says... Continued Research Needed to Find Causes of Cancer and Other Major Diseases [Council Pledges to Continue to Give Financial Support to Scientists Studying Smoke-Health Issues]
- CTRMN005461-5462 $6 Million Granted for Smoking-Health Studies [Millions Given to Scientist for Further Study]
- CTRMN005463-5465 Tobacco Research Group Continues Funding for Independent Scientists [Council Has Provided Millions Over the Years to Researchers and Will Continue to Do So]
- CTRMN005466-5467 $5.5 Million Given for Smokin-Health Studies [Council Has Given Millions to New and on Going Studies Over the Years]
- CTRMN005468-5469 Annual Report Issued by Tobacco Research Group [Over 1.5882 Reports From Scientists Acknowledging Support From the Council Have Been Published]
- CTRMN005470-5473 $6 Million Awarded for 34 New Smoking-Health Studies [Millions Were Given to Scientists with New Studies and Continuing Ones From the Council]
- CTRMN005474-5474 Ctr's Latest Report Sets Abstract Record [More Reports Were Published From Scientists Acknowledgingg Support From Council for Tobacco Research Than Any Other Report Published in the Past]
- CTRMN005475-5475 Scientists Show... Growing Interest in Doing Smoking and Health Studies [Growing Number of Application Have Gone to the Council of Tobacco Research for Funding on Smoke Related Diseases]
- CTRMN005476-5479 $7 and A Half -Million Awarded for Smoking-Health Research [Millions Given to Scientists for Studying Lung Disease]
- CTRMN005480-5481 Council for Tobacco Research Announces... Hoyt and Hockett Retire After 30 Years: Gertenbach Is Named New President [Introduction to President of the Council for Tobacco Research]
- CTRMN005482-5482 Ctr's Annual Report Sets Abstract Record [the Number of Reports Acknowledging Support by the Council of Tobacco Research Is More Today Than It Was Years Ago]
- CTRMN005483-5485 Findings Published on Cigarette Smoke Inhalation Study with Mice [Results From Study Show That Smoke Did Not Produce Any Squamous Cell Lung Cancer]
- CTRMN005486-5525 Statement of Dr. Clarence Cook Little, Scientific Director, Tobacco Industry Research Committee, at Press Conference, University Club, New York City, June 15, 1954 [Regarding Relationship Between Lung Cancer and Tobacco]
- CTRMN005526-5533 "Transcript of Edward R. Murrow's First Tv Show on "Cigarettes and Lung Cancer"" [Regarding Experiments That Show That Cigarette Smoking Increases Chances for Lung Cancer]
- CTRMN005534-5541 "Transcript of Edward R. Murrow's Second Tv Show on "Cigarettes and Lung Cancer"" [Regarding Issue That Cigarette Smoke Does Not Cause Lung Cancer]
- CTRMN005542-5562 the Lung Cancer Problem and the Research Program of the Tobacco Industry Research Committee [Regarding Continuation of Study Dealing with Tobacco and Health]
- CTRMN005563-5573 A Report of Progress [Results From the Study of Smoking and Health Issue Will Greatly Depend on Well Planned and Well-Executed Scientific Research]
- CTRMN005574-5585 Tobacco and the Cardiovascular System the Program of the Tobacco Industry Research Committee [Program Strives to Discover Facts and Relationships Described with Objectivity]
- CTRMN005586-5597 A Search for Facts [Regarding Information Needed to Be Gathered on Smoking and Health Problems to Defend Industry]
- CTRMN005598-5605 the Lung Cancer Problem and the Research Program of the Tobacco Industry Research Committee [Discussion on Different Studies Will Continue to Be Made Until A Answer Is Found]
- CTRMN005606-5607 Cancer Research Guest Editorial Smoking and Lung Cancer Volume 16 [St Regarding Support Given to Scientist for Research]
- CTRMN005608A-5609 "Correspondence Regarding "Smoking and Health"" [Discussion on Researching on Tobacco and Health with Objectivity and Not Be Judgmental]
- CTRMN005608B-5609 Hypfibrinogenemia [Regarding Transfusions and Clotting Mechanism in A Case of Extraordinarily Delayed Post-Partum Hemorrhage]
- CTRMN005608C-5609 Diabetic Children [Admitting Omission of Different Data From Other Sources]
- CTRMN005608D-5609 Revocation of Licenses [Revoking of Registration From Dr. Louis A. Scinta]
- CTRMN005610A-5613 Mayo Clinic Head Believes Smoking Not Cancer Cause Tobacco and Health Volume 1 Number 1 [Smoking Not Believed to Be Cause of Lung Cancer, According to Some Noted Physicians]
- CTRMN005610B-5613 Six Experts State Doubts on Smoking-Cancer Theory Tell Congressmen Reasons for Position Tobacco and Health Volume 1 Number 1 [Reasons for Not Accepting Theory That Smoking Causes Lung Cancer]
- CTRMN005610C-5613 New Book Says Tobacco 'scare' Not Justified Tobacco and Health Volume 1 Number 1 [""Science Looks at Smoking"]
- CTRMN005610D-5613 Editors View Smoking-Cancer Tie As Unproved, Open Question Excerpts From Editorials Tobacco and Health Volume 1 Number 1 [Excessive Smoking Probably the Main Cause of Lung Cancer, While Moderate Smoking As Causation of Lung Cancer Has No Scientific Support]
- CTRMN005610E-5613 British Scientist Opposes Campaign Against Smoking Tobacco and Health Volume 1 Number 1 [Sir Ronald Fisher, British Statistician, Refuses to Produce Anti-Smoking Writing, States It As A Cause for Anxiety]
- CTRMN005610F-5613 'pick Your Expert, Take Your Choice' Tobacco and Health Volume 1 Number 1 [Witnesses Linking Cigarettes to Lung Cancer Testify Before House Operations Sub-Committee]
- CTRMN005610G-5613 'still Open Question' Tobacco and Health Volume 1 Number 1 [Authorities on Cancer State That Smoking Is Not Proven to Cause Lung Cancer]
- CTRMN005610H-5613 Smoking and Death Rates Tobacco and Health Volume 1 Number 1 [If Everyone Stopped Smoking There Would Be No Significant Change in Death Rate]
- CTRMN005614-5616 Summary of Comments for Delivery Before: Central Subsection, North Jersey Section, American Chemical Society, Elizabeth, New Jersey [Review of the Chemical Analysis of Cigarette Smoke and Investigations of Smoking and Lung Cancer]
- CTRMN005617-5620 the Public and Smoking Fear or Calm Deliberation? [How Doubt, Suspicion and Fear May Affect the Deliberation of Whether Cigarette Smoking Causes Lung Cancer or Other Ailments]
- CTRMN005621A-5624 TIRC Reports Progress in Smoking-Health Research Tobacco and Health Volume 1 Number 2 [Too Many Unknowns Exist Concerning Lung Cancer to Warrant Conclusions Citing Smoking As Causation of Lung Cancer]
- CTRMN005621B-5624 'tar' Misnomer for Condensed Smoke Tobacco and Health Volume 1 Number 2 [Difficulties in Analyzing Tobacco Smoke Make Tobacco Tar A Misnomer]
- CTRMN005621C-5624 New Statistics Contradict Anticigarette Theory Tobacco and Health Volume 1 Number 2 [Cigarette Smoking May Be Compatible with Normal Health Report on Done Smokers Who Have Longer That Average Life Span]
- CTRMN005621D-5624 TIRC Funds for Smoking Research Now Over $2,000,000 Tobacco and Health Volume 1 Number 2 [Scientific Advisory Board Approves 52 Grants and Renewals in 1957 Totalling $550,000]
- CTRMN005621E-5624 Press Questions Anti-Smoking Plan Tobacco and Health Volume 1 Number 2 [State-Supported Campaign Against Cigarettes Warranted in New York]
- CTRMN005621F-5624 Study Suggests Bronchitis May Be Prime Factor in Lung Cancer Tobacco and Health Volume 1 Number 2 [Preliminary Study at Beatty Institute Favors Bronchitis As A Factor of Lung Cancer]
- CTRMN005621G-5624 Doctors' Comments on Smoking-Health Tobacco and Health Volume 1 Number 2 [Increasing Number of New Chemicals in the Atmosphere at Fault for Rise in Cancer]
- CTRMN005621H-5624 Nation-Wide Lung Tissue Study Now Being Evaluated Tobacco and Health Volume 1 Number 2 [TIRC Studying Lung Tissues From 1,600 Persons]
- CTRMN005625-5648 Biological Aspects of Cancer Research Journal of the National Cancer Institute Vol. 30, No. 3 [St Background Research and New Information on Cancer Studies]
- CTRMN005649-5654 Interview the Cigaret Smoker and Lung Cancer Reprinted From Modern Medicine, Vol 26 [St Advises on Smoking and Its Relation to Health]
- CTRMN005655-5660 Comments on the Mortality of Smokers and Non-Smokers. A Paper by Harold W. Dorn Before the American Statistical Association Dec. 27, 1958 [Reflections on Figures Presented in Dorn's Paper]
- CTRMN005661-5671 An Experimentalist Looks at Statistics on Smoking [Reflections on the Figures in Dorn's Paper]
- CTRMN005672-5672 Letters to the Times Findings on Smoking [Statistical Proof of Link Between Smoking and Cancer Denied]
- CTRMN005673-5683 A Brief Review of the Smoking-Lung Cancer Theory [Review of Data Known on the Relation Between Cigarette Smoking and Lung Cancer]
- CTRMN005684-5686 Cancer-the Research Approach [Discussion on Cancer and A Category of Factors Which May Play Roles in Cause and Development of Cancer]
- CTRMN005687-5692 [Address Before the Burley and Dark Leaf Tobacco Export Association, Inc. Information About the Research Program Supported by the TIRC]
- CTRMN005693-5697 Some Phases of the Problem of Smoking and Lung Cancer the New England Journal of Medicine Vol. 264 No. 24 [St Disputes Findings That Smoking Causes Lung Cancer]
- CTRMN005698-5704 Some Aspects of the Lung Cancer Problem Reprinted From Punjab Medical Journal Vol. Xi No. 7 [St Discussion of Relationship of Cigarette Smoking to Lung Cancer]
- CTRMN005705-5735 Current Knowledge of Tobacco and Health [Discussion of Experimental Attack on Lung Cancer and Tobacco Use]
- CTRMN005736-5739 Cigarettes-Why More Research? Reprinted From the Yale Scientific Magazine [St Comments on the Uncertainties of the Correlations Between Cigarette Smoking and Lung Cancer]
- CTRMN005740-5740 Why Do People Think That Quitting Smoking Affects Their Appetite or Their Weight? the Apothecary [St Comments on the Scientific Basis of How Smoking Affects Hunger]
- CTRMN005741-5754 Address to Be Delivered by Dr. Clarence Cook Little, Scientific Director, the Council for Tobacco Research - U.S.A. At A Dinner Honoring the Centennial of the University of Kentucky and the Burley Tobacco Industry Lexington, Kentucky January 12, 1965 [Talk Addressing Research Programs of the University of Kentucky]
- CTRMN005755-5772 Communications and the Biological Sciences [Brief Discussion of Principles That Should Inspire and Guide Communications in the Biological Sciences]
- CTRMN005773-5785 Perspectives in the Experimental Approach to the Human Lung Cancer Problem [Experimental Research on Lung Tumors in Animals May Lead to Insights on Human Lung Cancer]
- CTRMN005786-5798 Tobacco and Health Research [Elaboration on the Purpose, Research Practices and Studies of the TIRC]
- CTRMN005799-5805 Tobacco and Health Research [Discussion of Experimental Studies by the TIRC Concerning Smoking and Health]
- CTRMN005806-5813 the Research Perspective on Smoking and Health [Discussion on the Search for Causes of Diseases with Which Smoking Has Been Associated]
- CTRMN005814-5820 Tobacco and Health Research [Discussion of Studies on Cigarettes and the Diseases Statistically Associated with Smoking]
- CTRMN005821-5834 Tobacco and Health Research - Where Shall We Go From Here? [Suggestions for Continuing Studies and Research on Cigarette Smoking and Health]
- CTRMN005835-5852 A Look Ahead Smoking and Health - Where Do We Stand? [Talk on Chronic Diseases and Factors of Their Causation and Development in Relation to Cigarette Smoking]
- CTRMN005853-5854 Smoking-Disease Links Continue to Lack Scientific Proof [Discusses the Role of the Council for Tobacco Research]
- CTRMN005854-5854 Lawrence Promoted to Vp Post at Mmi [Jack Riddle Announces the New Vp of Micro-Magnetic Industries]
- CTRMN005854A-5854 Philip Morris Expands Promotional Allowances [Discusses Special Offers Made to Philip Morris Vendors]
- CTRMN005855-5882 Chapter 3 the Tobacco Health Issue: An Overview of Medical Research [St Questions Methodology of Experiments Where the Sole Objective Was the Attempt to Induce Tumors]
- CTRMN005883-5900 the Research Program (Cancer Segment) of the Council for Tobacco Research - U.S.A., Inc. Presentation Before the Tobacco Working Group [Describes the Concept, Plan, and Purpose of the Council for Tobacco Research]
- CTRMN005901-5902 Smoking Prevention Education Act Hearings Before the Subcommittee on Health and the Environment of the Committee on Energy and Commerce House of Representatives Ninety-Eighth Congress First Session on H.R. 1824 [Statement of Sheldon C. Sommers]
- CTRMN005903-5919 [Regarding Anti-Smoking Bill]
- CTRMN005920-5931 Hearings Before the Subcommittee on Health and the Environment of the Committee on Energy and Commerce House of Representatives Ninety-Eighth Congress First Session on H.R. 1824 March 9 and 17, 1983 Serial No. 98-8 Statement of Robert Casad Hockett Regarding H.R. 1824 [Disputes Findings Set Forth in H.R. 1824 Regarding Cancer, Cardiovascular Disease, Atherosclerosis and Emphysema]
- CTRMN005932-5932 Hearings Before the Committee on Labor and Human Resources United States Senate Ninety-Eighth Congress First Session on S. 772 May 5 and 12, 1983 [Concerning Smoking Prevention Health and Education Act of 1983]
- CTRMN005933-5940 Statement of Sheldon C. Sommers, M.D., Consultant in Pathology, Lenox Hill Hospital, New York, N.Y. [Comments on Smoking Prevention Health and Education Act]
- CTRMN005941-5963 Hearings Before the Committee on Labor and Human Resources United States Senate Ninety-Eighth Congress First Session on S. 772 to Promote Public Health by Improving Public Awareness of the Health Consequences of Smoking and to Increase the Effectiveness of Federal Health Officials in Investigating and Communicating to the Public Necessary Health Information, and for Other Purposes Statement of Robert Casad Hockett Regarding S. 772 [Disputes Methodology of Experiments Which Expose Animals to Smoke]
- CTRMN005964-6009 Hearings Before the Subcommittee on Health and the Environment of the Committee on Energy and Commerce House of Representatives Ninety-Seventh Congress Second Session on H.R. 5653 and H.R. 4957 March 5, 11, and 12, 1982 Serial No. 97-106 [Disputes Methodology of Experiments to Demonstrate That Cigarette Smoking Can Cause Lung Cancer in Animals]
- CTRMN006010-6012 Testimony of Dr. Robert C. Hockett During Hearing on Cigarette Smoking and Health Before the Subcommittee on Oversight and Investigations of the House Committee on Interstate and Foreign Commerce, October 5, 1978 [Responds to Question Regarding Research on Health and Smoking]
- CTRMN006013-6023 Statement of Robert C. Hockett, Ph.D. Before the Subcommittee on Oversight and Investigation of the Committee on Interstate and Foreign Commerce in Response to the Letter Dated September 27, 1978 From the Chairman of the Subcommittee to William U. Gardner, Ph.D., Scientific Director, the Council for Tobacco Research - U.S.A., Inc [Discusses the Purpose of the Council for Tobacco Research]
- CTRMN006024-6069 Hearings Before the Subcommittee on Health of the Committee on Labor and Public Welfare United States Senate Ninety-Fourth Congress Second Session on S. 2902 February 19, March 24, and May 27, 1976 [Disputes Scientific Basis of S. 2902]
- CTRMN006070-6125 Hearings Before the Consumer Subcommittee of the Committee on Commerce United State Senate Ninety-Second Congress Second Session on S. 1454 Serial No. 92-82 [Discussion of Cigarette-Smoking and Peptic Ulcers]
- CTRMN006126-6135 Report of the Scientific Director [St]
- CTRMN006136-6189 Hearings Before the Consumer Subcommittee of the Committee on Commerce United States Senate Ninety-Second Congress Second Session on S. 1454 February 1, 5, and 10, 1972 [Discusses Edimeological Comparisons Between Smokers and Non-Smokers]
- CTRMN006190-6200 [Bibliography Listing Over 1,275 Articles and Books About Tobacco and Disease]
- CTRMN006201-6311 [Articles About Tobacco and Disease]
- CTRMN006312-6321 Hearings Before the Consumer Subcommittee of the Committee on Commerce United States Senate Ninety-Second Congress Second Session on S. 1454 to Amend the Federal Cigarette Labeling and Advertising Act to Require the Federal Trade Commission to Establish Acceptable Levels of Tar and Nicotine Content of Cigarettes [Statement of Dr. Sheldon C. Sommers]
- CTRMN006322-6348 Hearings Before the Consumer Subcommittee of the Committee on Commerce United States Senate Ninety-Second Congress Second Session on S. 1454 to Amend the Federal Cigarette Labeling and Advertising Act to Require the Federal Trade Commission to Establish Acceptable Levels of Tar and Nicotine Content of Cigarettes [Statement of Dr. Robert Casad Hockett]
- CTRMN006349-6359 Hearings Before the Consumer Committee of the Committee on Commerce United States Senate Ninety-Second Congress Second Session on S. 1454 to Amend the Federal Cigarette Labeling and Advertising Act to Require the Federal Trade Commission to Establish Acceptable Levels of Tar and Nicotine Content of Cigarettes [Statements of Dr. Sheldon C. Sommers and Dr. Robert C. Hockett]
- CTRMN006360-6370 Hearings Before the Consumer Subcommittee of the Committee on Commerce United States Senate Ninety-Second Congress Second Session on S. 1454 to Amend the Federal Cigarette Labeling and Advertising Act to Require the Federal Trade Commission to Establish Acceptable Levels of Tar and Nicotine Content of Cigarettes [References Reporting on Tobacco and Nicotine]
- CTRMN006371-6412 Hearings Before the Committee on Interstate and Foreign Commerce House of Representatives Ninety-First Congress First Session on H.R. 643 A Bill to Amend the Federal Cigarette Labeling and Advertising Act with Respect to the Labeling of Packages of Cigarettes and for Other Purposes (and Similar Bills) [Statement of Dr. Sheldon C. Sommers]
- CTRMN006413-6492 Hearings Before the Committee on Commerce United States Senate Eighty-Ninth Congress First Session on S. 559 and S. 547 Bills to Regulate Labeling of Cigarettes and for Other Purposes [Statement of Dr. Clarence C. Little]
- CTRMN006493-6533 Hearings Before the Committee on Interstate and Foreign Commerce House of Representatives Eighty-Ninth Congress First Session on H.R. 2248 A Bill to Amend the Federal Food, Drug, and Cosmetic Act So to Make That Act Applicable to Smoking Products [Statement of the Council for Tobacco Research U.S.A. History and Organization]
- CTRMN006534-6540 Hearings Before the Committee on Interstate and Foreign Commerce House of Representatives Eighty-Ninth Congress First Session on H.R. 2248 A Bill to Amend the Federal Food, Drug and Cosmetic Act So As to Make That Act Applicable to Smoking Products [Statement of Clarence Cook Little, SC.D.]
- CTRMN006541-6548 Hearings Before the Committee on Interstate and Foreign Commerce House of Representatives Eighty-Ninth Congress First Session on H.R. 2248 A Bill to Amend the Federal Food, Drug, and Cosmetic Act So As to Make That Act Applicable to Smoking Products [Statement of Robert Casad Hockett, Ph.D.]
- CTRMN006549-6577 False and Misleading Advertising (Filter-Tip Cigarettes) Hearings Before A Subcommittee of the Committee on Government Operations House of Representatives Eighty-Fifth Congress First Session [Statement of Dr. Clarence Cook Little]
- CTRMN006578-6611 False and Misleading Advertising (Filter-Tip Cigarettes) Hearings Before A Subcommittee of the Committee on Government Operations House of Representatives Eighty-Fifth Congress First Session [Statement Concerning the Origin and Purpose of the Tobacco Industry Research Committee and Its Proposed Functions]
- CTRMN006612-6614 False and Misleading Advertising (Filter-Tip Cigarettes) Hearings Before A Subcommittee of the Committee on Government Operations House of Representatives Eighty-Fifth Congress First Session [Hartnett Cites Scientists Doubting Smoking-Cancer Theory]
- CTRMN006615-6618 Research Into Smoking and Health [Arguments Against Tobacco Cancer Link]
- CTRMN006619-6623 [Study to Examine Reported Causes of Death in Each of 17 Regions in Houston Specifically the Five Major Respiratory Diseases]
- CTRMN006624-6624 A Frank Statement to Cigarette Smokers [Industry Promotes Research Into Tobacco Disease Link]
- CTRMN006625-6625 the Council for Tobacco Research - U.S.A., Inc. Board of Directors [Members of the Board]
- CTRMN006626-6627 the Council for Tobacco Research - U.S.A., Inc. Scientific Advisory Board [Members of the Board]
- CTRMN006628-6634 No. E-121,486 I. D. Rogers, Individually and As Independent Executor of the Estate of Marjorie Helen Rogers, Deceased; Et Al Vs. R. J. Reynolds Tobacco Company, Et Al in the District Court of Jefferson County, Texas 172nd Judicial District Third Amended Notice of Intention to Take Oral Deposition [Matters on Which Ctr Witnesses Must Be Knowledgeable]
- CTRMN006635-6967 Deposition of Dr. James Glenn [Deposition of Glenn in the Matter of Broin]
Related Documents:
Document Images
REPORT
111/: l'O1'\l'll. 1OH Il>IS\('('O Kt~:~l::\H('U-1'.\. \.. lu:.
+/lh! 1 l+lnl A.cnur.
i
r
aC1ENTIFIC ADVISORY BOARI)
o Thc Council Gx Tig>rrru Rc..c.rch- U.S.A. Inc.
u of Lkccmbcr )1, 1yts} PI:(I:K M. lI()WI.LY, M I).
t.rhrNruNy 611 Patl>.rlugy
N: tuxirl ('arwci In.tnutc
Iicthcsda. Maryland
~
~
III:NKY T LYnCH. M.D.
~
LEON O. JACOBSON. M. D.. Chuirmun l'nr/rssw unJ Chuirmun
uul Scirnrrs (rmrritus)
P
Hwfu I),cparlnknt of 1'rcvcntrvc McJtctnc and Public Ifcalth
rofessor uj
g
Jusrph Rrxrnsrrin
Prufrsstrr ujrhr lNpurtmrnt r,JMrJa'inr (rmrruws) l'rufrsuur u/ Mribrrnr
' U
Univerarty of Chicago l
rrsulrnr. I lcrcditary Canccr Inaitutc
('rcrKhtrm Univcraity Schuul of McJwrnc
Is
Chicago. lllmoia
Onraha, Ncbra%ka
RICHARD J. BING, M.D.
Dirtcurr of E.yxrimrntal CarJiuluKv arrJ Sr+rnnfic Drvrlupmrnt
Huntington Mcdical Rescarch Instituto. Paaxkna. Cabforma
Visiting Asxxiett
California lnstitutc of Tcchnology, Pasadcna
Prufrssur ojMrJicine (emeritus)
Univcraity of Southcrn California School of Mcdicinc
Los Angcks, California
ROSWELL K. BO(JTWELL, PH.D.
Pruftssur of Unrrdogl
McArdle Labrxatrxy for Canccr Rcxarch
Univcrsity of W isconsin
Madisun, Wixunain
DRUMMOND H. BOWDEN. M.D.
PrnJtssur and Hrod
Drpartment of Pathology
Univcrsity of Maniloba Health Scicnccs Ccntcr
Winnipeg. Canada
MICHAEL J. BRENNAN. M.D.
Prrsitknt and Medical Director
Michigan Canccr Fuumlatiurr
Dctmir. Michigan
JOSEPH D. FELDMAN. M.D.
Member (rnrrruru). Rescarch Inmutute of ScrtPPs Clinic
Scrippa Clinic and Research Foundatrun
La Jolla. California
EdiaK. Jrwrnal rr( Imrrwuurk,gy
San Drego. Cahfurnra
G. BAKRY I'Ii:RCE. M.D.
Amrrirun ('anrtr Srwirtv Centennial Resrurrh Prufrrsur
Urriver.uy o( CulunAo Lkalth Scrcnces Centcr
Denvcr, ColoraJo
GORDON H. SATO. PH.D.
t)urvtur
W Alam Jrmc. Ccll Sricncc Centcr
Lake PIx:iJ, New Yark
SHFI.I)ON C. SCNMML:RS, M.D.
Scrrntifii Dirrrarr, The Council forTubacco Rc.carih-11.S.A.. Inc.
Clinrcul l'nrfrssur of Pathology
Cullegc uf Physicians & Surgcunb. of Columbia Unrvcrauy
New Yurk, Ncw York
Scicntibc S1afT of The Council
SIIIiI.D(NV C SOMMIiKS, M.D.
Sr trnq/ir Urrrrrur
DONAI.D 11. Ii)KD. L'N.D. HARMON C. MCCAL.LISTI:K, Jk.. Pit t)
A»uciulr Rrsrurrh Dtrrrtc.r Assrw-ittr Rtsturr h l)urrwr
VINCI:NT E 1.11ANTI, D.M.D. DAVID STONI:. PH.D.
AssrKturr Rrsrurrh Urrrrtur Asxnrurr Rrsrurch l)urrtAa
WILUAM U. GARDNER. PRt D.
Proftssor uf Anutumy (rmrruas)
Y.k llnrvcnpy Schrr>a of McJrcinc
New Havcn. Cumcctrcut
CONTENTS
InIr/rJuautn . . . .................. ........ . . . . . . . . . . . . . . . . . . 5
Ahasract% ul' Rcplxt. . . ... . ... ..... . .............. ...... . . . . 7
('an.crRrlrtcJ Studlr. ...... . ....... . . . . . . ... ... . 7
7-fx Ltc.plrattxy sy>Ictn ..... . . . . . . . . . . . . . . . . . . . . .... ... 21
11car 1 rnJ CtrCulatran ...... . ...... . . . . . 541
Nrur.>{ttwnuacl>lo}y anJ Phy+luhtly. - . .... . KU
Nharnr:tl:oktl,ry anJ Huxhcroulry, . ..... . . . . ........ Kh
Lnmunulugy .nd Adapuvc Nkrhant.m. ........... .. ..... . ili I
Lptdcmtulagy .................. ........... ... ....... I 1 K
ACl lvc i'ntjCi n ...................................... . . . .. ..... 122
CurnplctcJ I'rujerl. ........ . . . . . ..... ......................... . 1,11
Indcx u! pnnrlpal Invc.uplwa ............ . ....... .... .... . . 144
lnJex of Scnr/r Atuhors .............................. . . . . . . ... 146
Introduction
®
111 19,17. It11CC yl'rll JIICI Ih I/xn1311Un. IIK C UUM'II I1x T IlhJlt/1 H\'ll`Jtlh I1111N1'l)
JINI l11\tllhull'll lhl' III%I 111 wtrJt hclJnK' :InnuJl rl'plxt. Itt.uMJln JhlllJlh 111 hPubr\
1hJt had Ikcn Iluhlt.l>td in v:rrluu..rlcnslhi nkJla with J.AnuwlcJKerrl.m u1 ('uwwll
aupputt. lhclc wcrc uoly 16 rh%tr.ct. In that lun}.gu J.wunlrnt II hJJ. unJ~r.IJnd
.bly~lal.cn sww lut otgrnvalrun. Icvtrw ;tnJ.pprwv.l uI glJm Jpph:Jhun, h) the
('Iwlk 11'v Sc Irnullc AJvlxwy 1104141. rcxrrch Iu lk ctrnlplctcJ. .rnJ mrnu..l yll% tu tw
prcparcJ, .uth^lIUeJ .nJ arccptrJ /ur puhhrubun
l4y mid IIM7, tlk hxal number ul vetrmlhc puhh.anun% r:L.nuwlcJl:ulg C"Intnal
.upplxt wa. Mh, and ten ycau later Ihc hgurc had n.cn tu 1,k/7 In tln PJ741 annu.tl
rcplnt. 196 uI.nulrc puhhcxuon+arc ahararleJ, the l.ttge.r nuluhcr /n.ny utr< )cu
Thl. hgurc hrln}% tu rt lc.vt 2,3S41hc tlNal nunlhcr ol .c/cntrh. pal*r..x'AnuwleJfrnk
('/wncIl.uplxlrt puhh.hcJ an.c thc C"uunrtl bcg.rrt,uppttning rc.rut.h by InJrprnJcnt
~ilcnsr.u Inw.nntL,tng atJ health.
-Chc.e puhhcanlma :uc rn tnvallrwblc .rwnc ul tnhxntatulrt r/>,1 rrlrrrn.r hx
rr>. ar. hcr.. vrrywhcre :uw/. Jxrelorc, rcprrxnt ./ nraur rutxrn/muut tu thr a Icnuh:
Incralurc. Tlw y.tlu/ ran hc cun+IJrrrJ..ymMtl u/ a rcx.uih prugr.rnl th.n hJV hcilmk
the niua cxt.n+l.r rlhxl ut tb kind in Ihc wlxlJ.
L.a>t ycar. thr ('I)wutl utrrca+cJ thr annual huJ}e1 lur nN rr.rarih prugrrnt and
nulnt:rrncJ Ihr tnl7cJw IUr Ihln. yl'Ar Tht\.KINxr b Irttla'.ttlva ttl Ilh' ('uutx II".IkJKa
tton hl Illc prngr.lm.
A. Id shr cnJ /11 1983. sh. C/wrwll'. .111-yc.r pougnnl h.u pr/llukd wlnK
SlS.4.l11111,11/I1/ tn 497 In+c.1tE.N/x. !/x AS Ixlgln.rl pruXcu in 279 ured/i:rl .a"htNd%.
hn.pnrla.nJ rr.cuch tnstslwatna.
S
Abstracts of Reports
Fulluwurp .rn rh.tr.xl., .rlhM.uv..1 by Ihr rullupr\ UI rC11UfIs un Ix'N r.'.nur Ir
:xA1M/wICJ):111~ %111ryMN1 I1rNn I hc Vrwn.rl that hrvc rl>twricJ in .axnulx µ.urnrl.
.ux'c puhh:ruun ..1 thc 1482 Kcl>trrl '1 hc nrnts: uf tlk grrnl acipt.nt rs rn nrh.r
1'h. :IhNrra I% rh' IGNN!(1CJ Wxll'r lha'M: hlJJInp% I( dnCCr HclrtcJ SurJrr,. 11
~
'(Ik H..prrrp-ry 1ymcM. 111. I lerrt and ('rq ulrnr.n. IV Ncuruldrrrnax'riluEy and 1.-
I'hy.ruhrEy, V I'hrrnlacuhlgy and IiawlKnustry VI InuuurxduEy and AJrlutvc
Mcchrnm+m. V II. LprJcMNrlugy. U
m
l. Cancer-Related Studies
I:VOI.IIIION 01- A('11VA'IION I)li1'OXII-I('A711)N I:NlYMf:l'Al-1l:KNS
I)1IK11yG PHI'.('AK('IN(X~I:NI'.SIS IN SYNIiKGISM:
3-MI:1/IYI.('II()I.AN'I IIKl:NL ANt) l)IML'I IIYLNITK()SAMINI:
'] IM w1lrAln)1 hyIllNhlll? UI this slualy rs thrt puln>,mrry ~yM':1rCIM1 fl'M:~I~ hc
twcru I>.Jy.yclx' hyJnKrrtxrn% and nruunrnunr% l. Jue tu the rcctpuwrl cllc. t% ul the
rFl'M\ I/n thelr rlwn rnJ rNl l'7l'h Nthl'r'\ InClr1A1IK f1:LLAwr) 1'u tr.l th~., lhc rllc~h uf
3 wclhyl.hMdanthrenc 13MC) rnJ JrmclhylMtru.rruun (l)MN). rJMrm.r.rcJ singly
ur in cumtnnru.rn u chnmrc crrriMrgcnw Juse. am the cvulutrun u1 rcuvrry prtncrn%
involvcal in Ihe nx:trMrh+m of DMN and frrrlyry.lt< hyJrrw:rrhvn% w'crc studied in the
hve r and lung ul 11xr fur 1)rwlcy rrr. rnJ Swr.s ou.r l lie Jru x: umulrtcJ in the rrt
audre..uggc+l that in tlx hra vlrEc aul lir Ixrti'e.u. rt 7 wceA.. llx rc rs'cuw. r Jci rer.cJ
arhvruun rnJ rnrrer.eJ JcluarlkcrlNrn ul iMC: thu rs fulluwcJ rnwMl IS wccA. by a
gnrl rnrrcr.r ul rruvrurm runcurnumt wnh rk. rca.rng rktusth. rurrn 'fhr rxl rc.ult
ul the.r rchvuy ch.nl;cs may be a high carx'entrruun u1 rcu.rleJ mlrrrnrJrrtc..l
3M(' in the lung. Alvr, lhe nrxkrxe enh:ulccnknt ol xuvrty MMrJ wuh 1)MN J in Ihc
lung ol wlv (:xhrum.hrcJ DMN ur DMN t iM(') wuuW .rnulrrly 1rrJ lu rM rcr.c in
Ihc rcxlrvc nx'IrMrhtclv) ol DMN 'I'hr..nJ uthcr Jalr .uyge.t that tlw fxcvuru.Iy
uh.crveJ pulnMrnrry.yncrrrtnu~crk.ry hclwecn iMC:rnJ DMN in rrt. i. prr.hrhl$ Juc
to increase ul re.r:trve nKtrlxrhte. ol Aonh 3MC rMl DMN In Ihe nMlu.c Irver. rro lhe
dher h.uW. a cumhrnatnro ul initial uxreaae ul efxrxxk h)Jrr%.c and IIUP-EIu.'ur.myl
trrnacrr.e rctrvrty at S wccM.. tul;cther with Jerrer.e aN AHH riuvrty rl Ill wecA..
.u):}e.ts a decrease u( rctrvrtcJ hyJrrwrrhm nKlrtwlda'% .vrllrhle Lw hukhnf ur
mrir.mr~dcaula. fhruvcrrllJrrrprewnlcJhrrerr. cun.racntwuhlx.vuru.td...rvr
uom% dtrt rrlrvrt.J ntetrtrrhte.nnEuwuog IruM hver rre unlikely arlx.r-ntnbuxue rn
1)MN r 3M(' IwlnMaury .yncrrcuxrl;crk.r.
Lri, 1) Y, Itryrur. (: M. Myar.. 1(' . W.%r. Y 1' ArKus. M 1` . rrx/.Sr..-r./ ('
Hrrrur. Ir ~rrpJ ('hrrr..d Ow-.L.g% 103 _'_724tl. IYI{_'
1'rum dr Ikprrturrnr ul McJw'uk. Tulrn. llnrvcr.rty Medical C'cnlar. New Uricrn..
('UMI'AKAI IVI Pl/l MONAKY'IUMOKIGI'.NI.IIS IN INiA._'1 rnJ ('S7ULb)
MI('1: 11Y AI)MINI.1'IKAfION OF .1MI:IIIYI.('llOI.ANTIIKI:NI. ANl)
I)IMI:I 111'I.NI I K()SAMINI'. SIN(;1.1' ANI) ('()MIIINI.I)
In tlus puhiw-urr) luuwn}irM>r..tuJy. ('57111 tJ wr:. vwhah rrc I/xhxJlle Ira
IwHhlxprtw'rnJlxr6rwm.ryrrylbyJr.wrrMarby.lu~.ylr.clAlilll.rudl)ISA _'1rm.c.
1
l
wln.h Jrc rMNrIrMlwlhlr /ar hLp.1/N' AIIII (1ut rlMMkrJICIy 1nJucrblc lur 1N1111M1rIJry
AIIII. rc:cts.J JruNthylurtrsr.,utunc IIIMNI t p. 1N nM'ihyhlwl.rnlhutM' IM('AI
rrrJll). ur J:urnMnJU,In ul h.Nh Jl;cnt.. lur Itl wccl., thc uuurJl. wcrc ah.crvcJ IrK rn
aJJrurarJl 10 wccl. The lung {c.ron. induced here were JlwaluEcmi tunMU. JnJ
J.IcdnnJlua. Alvcnla~cnr.tunMU.wcrcrnJurcJmJUSU.hIJrF.rnundxrull)liA/21
mrcc than in ('S7B1/hJ mtcc. It. howcvcr, thc sum o/ Jlvculugcnr: tunr.K. JnJ JJcnu-
nuhw. nlMlulcs r% c1m.rJcrcJ and rs cxpre....cJ I><r lung Ic.tun I>LJnng nMlu.c. thcn
Ihcx rJ(fo> :rrc Irlr thc cunltul, MCA. DMN and MCA + l)MN Eruup.: 2 7, I S. ) 5,
and S.J in the UHA/2J nuce and 1.0. 1.1 2,7, and 3.6 in ncs, CS71i1/AJ uuic, rc.lk.-
Irvcly. Thr..uggea. a rclJrivcly greater +u.ccprrhrlrry ul thc ('S71i11b1 ntfrrn rl,hc
r:ItNN Jfe l'lHllrafl'11/.1 thl' fe%111'Ct/Ye CHr11p1I vJIuC1. I711\ FHJICr \rrN'cIN/hlllty 1/1
r1K
('S71iI161 rs t>La seen by r:utupJnng the pcr:cnt rrrrrcJ.c nl thc r.ruu Iru thc M('A r
DMN gnwp., thc nct increase ra I/MI'4 hw 1)IIA/21 and 2M)'.f lur ('S7111/6J.
Argus. M I~., tllMrh-Ltgetu, C. and Arrus, J. ('.
Nrup/usnwr'_'1!5):5.7-5.11, W82.
hrsxn ScJn><n'. McnMlrwl Rc.cJrrh 1-Jh~xaurry. (1. S I'uhkc HcJlth Scrvric Hu~puJl,
New U~rkJn., .rnJ the 1)lPJrtrrnnt ul McJrrrne. Tulurc University McJr..l Ccrucr,
New Orleans.
IN('KEASFI) Lh.V1:1. OF PKOLA(TIN GI:NIi SI:QUIiNCLS IN
HKUMUULUXYUKIUINL TKL-ATLU Gl1 C'1:Ll.S
'Clx thytnrJine an:rlul:ue. 5-harnxltkuayunJrne (HrJllrJ), has been klurnl tu
intlucnrx .cvcr.rl Jrllerentr:rtcJ lurrcriurra in vJrrau% eul.:rryutK .cll.. LJrlwr +tuJrc
have .Iwwn tha HrJUrJ inrtlrppwaes rnlo cell DNA replacing thymtdrrrr:. and thJt
InJuauln ul prulxun (PRL) aynthr:ar% by the JnrE .eem% tu hc dependent lur 1)NA
synthe.n JnJ .uch h.x .uhaituuun.. In the re.ult. reptlncJ hcre, it w.. xcn thJt the
S-brurrw Mkuxyurrdrnc-rc.u(.M I BfJl1rJ ) rk nvatrvc I k, H(iH,1C, ) ol prula: hn rMrrqxu-
Jrxmg (PKI. 1 rat pituitary tunwrr r:ell-.ubcklne G11,2(' .ynthc.uc. PKI. in tlw
presence ul the drug. Analy.r. ul nrxkar KNA uul.tcJ Irum BrJUrJ ItrrJlcJ
F,B(iH,2C, rcllafknrrnratrNCJ xver.l high nurkLul.rr weryChr KNA,,, xyur:ntc., .rrnr-
l.r tu rtMr.e r)bxrveJ in the rwckJr RNA IartMln rrl PRI. pnrJurrng (PKL- )(it1, rcll..
Nu such KNA,,, vcyuerweu r:uuW be detected rn nuclear RNA trJcurrn ut untreated
P,B(iH,2C, ccliv. PKl..cyuernc% in the gefMMrrc ul (ill, ll'KI.' 1. (i11,2(', 01141. 1 Jrn1
1=,HCiN,2C, IPKL . HrJUrJ, GH cells crwlJ he iJentdreJ by M.M .urJlya. in 4 M S 21.h
Ir.gnren( ul revtnctMln cntklnucka.c, IhoJ 111 JrgcacJ 1)NA. tiuth PKL and I'KI.
rcll..ecnr la have apprulsuratcly the vnre kvel ul PKL fcnc .cyu.nccs in aHJl.cll
1)NA, lluwcvcr, HuM1 III Jrgc.ICJ l)NA ul BrJltrJ trcJtrJ I,li(i11,2( , rclh rrvcJlrJ
the pre,%crne ul wtgnrhr.mly Mghcr kvcb 44 PKL )errc .cyucntc.. in aumprrr..ur ttl
thal uh.crveJ in aNa DNA sd untreated rcll.. The tnrreJ.cJ level ul I'KI. FctM:
xyucn.c. wa. Jcpentkm rrn the (1en1M1 rd drug 1(rJtrrunt JrMI J r.rJ1k 1 urarcJ.c tn IIM:
ryhlPlavnrM: KNA,,, seyuencc% wa. Jlwr f/h.erved.
NnMU.I. 1). A JrMI HJnc., S I).
Nwr Irrr A, rr/l Kerrufr h IIN131 j`1')S11M)M 19M2.
Other suppru7: NJp1MUl Cancer In.uwte
1aMn Ihc LJt>,rr,uury ul I'h.rrrnxulugy. IIJrvJrJ 1.IMMd ul IhutJl McJorur.. and tllr
Ikp.rrtutculul t'Ir,uurxukll;y. Il.rrvJrJ McJt.Jl S.h.Md, 14u.tun
lil'Nl ll(' ANI) I.X1l.KNA1. KI.(i111.A71UN 01 NATUKAI. K11.I.1.K ('1.1.1. ~
l'Y I()I/)XIl'I I Y IN MI('I: .-y
NJIurJl A/ll.r (NK )..Il., whtch.rn»ttlutr urwul Ihr: natural unmuu. nM:. h.rnl.rov
hll\tulJtlJ tl/ r/IJy :1 r1/Il rn lllllnK Jl.rlnlt rK1111IJ%tll' 11CVCIIIIMIK'llt and
nll'IJ\IJ\r\, Jrl
rc ful,ac.l hy Jl numhcr ld gerrcK cuauulhnE md lmly NK cell nun>I>tr hut Jlw th. rf lylt.
ability In many .tr.un% ul mtce, thc rMlrm.l kvrl ol NK x'hvtly Jrrnmr.hc% wnh JEc
In tht, I1JIM:r, .tuJtc% un I I rnhrcJ JrMI rci unrhrnrnt inbred arJrnl ul nu: c, JnJ .onk 1o1
tlM:u hyhrtJ., ,nr prc.cntcJ. 'lhcy sknMnrarJt. thJr Ihc }r:wluJl lu. id rMlnnJl NK
:ruuv tly wrlh J}rnl: t. JLu:rc.unrp:lnrcJ by a kl.% in Illc ability tu rc.~,nJ tu tn,crlcrun
uuluruun wnh Jn}nrcnrr.l NK J.hvny, I unhcr, cvr.klM:c 1\ prNVIJrJ II1.r11J11I1renv~
GI2
!'ooll
41
~
U
tu Ear.uyltc cJn lurMluic 11ran1Jn: JoIl.rcrM:cv in NK ..nvuy fn nu.c .hrum.Jlly ~
c61N/.lJ ru i1 vuu% rn Jcunt.111unJ,cJ nMru+C cU11N1y Irn.uy. aVcoMarr JOJIy\r11/I tIN
cll:ct nl in 1rtM.ugenrc agent. PrraJrlr, uu NK ..uvny r. IxcwnlcJ 1'rr.tJrrc. whnh
lmlucc, plJ.nlacyuuu.r% ro surn muJrn% ul rurtc, .ich.h dlc HALW.. .upprr..c% mu
unly Y cell and li tell rc~lxrn.c. but Jl.u NK activity. It r% tnrw .M/wo that there Jrc
.rgnrhrrnt .tr:rrn Jdlcrenres ln the cllcct ul Pr1.tJnc rm NK actrvuy, J. wcll J. Jdlcr-
crx'c% tu rccuvcry Iruru that Jcprc..Mm. PJnirulJtly .tuJr.% ul hybrtJ% reveal that Ihc
ErtMari nkcham.nr. rc.lllmabk 14K lhc prt.trne-tnJuccJ k»% ul NK activity in nc.
IIALH/r JnJ rn the CS7NI..Inm. Jrc n1N the .JnK.
Hhur, I'. B. rl ul.
In ('n.pcn K() IcJI (-urw rr' l:u-drlct unJ1'n crruMln. New YIUA l:I+cvrcr Scrcnrc
Publishing Cu.. Im., P1M3. pp. 1NI-14)1.
Olbtr srrpporr: NJuunJl ('arrrer In>trtule. ArnencJn Cancer S4M:tcl) and rcxarrlr
Iwr.b ul the University r/l C.Ilil.rrnrJ.
Urunr Ihe 1kpJnnrent ul Mtrruhrulugy and ImmurMllugy, and thc ('Jncer Kc.rrr.h
I.aMorJa/ry Ilnrvcr.ny u/ CJklrunrJ, Berkeley
INIIIli1'1'OK (I:LLS IN JPLI:LNS OF MICL WITH Ll)W NA"tUKAI- KIL1-LK
A(TIVITY
In.urvey. ul v:rraw% rnhrcJ.tr:rrnv ul mrcc lur rwtural killer INK) cell xuvrty
alrrl,tng vrrr:ruun% in n.urnJl rc.llnn.rvcrrc.N have hccn nutcJ. 1-ur c aJmplc- IiPS ratcc
rMK/uJlly have vrry klw.illccn.cll NK aruvrly lluwavct. thcrr NK Jruvrry.JU ht
vly:ruh.Jnlly Ju fuwmc.l wnh Ihc u.: ul an 1nr.r/cr.M1 rnJuccr, wlurh .ugr..t% that thlm
hcntc luw reJruvrly r% rnu J tcvull rlt Iaw numbe(% ul (lrccur..K ccll. lK JcIC.t. In Ihc
ly hr nrrchJnr.nr Wc rclMln thJt IIPti.pkcm:rwuJm vup(xeaa.u cc Il. J. rvr.krM:c.l hy
dlc Jhdrty 44 li1'l.placn.clh tn inhibit in lura the NK Jrtwrty ul .plccn.cllv Irunr
IuEh rc.l>.nl.kr .tfJUr, ul nlr.c ( l'Il% Il',IMqr%rhk IrN the ]ull(1hv-snNl JN kM J/CJ 1r1 (11N
rkn.c IrJI't11r11 JItc1 N'IIJIJtrIMI 101 rIUII-) Iy11 MItK and Jrc nykql wU11I ,nIlKK'Irt Ktncu:
auJIc. /nk.'Jt.' IhJr tlr. r11ClhAr/V1r sit rnllrhr11rM1 N n1M rrM:rely ~urn111'UOun lur 1Jr}ct-
hrrrdrny:.nc. AIIIM1u1CIr thCw WI111reoMrr cells lJn JCt lb1 rr6llurC NK rl Ic. t.u% ur 1 urr'.
llwu .r.ltvu) ui rn,t u1Jv he r1MMe iruupk.. .rnrc mJture BI'S NK cilcilur. Jrc tMu
rd vcakJ wIwn ,IM: .ul>11avvlr. Jrr r.nwrvcJ
filuu. Y)t . 1tJ\hJwr\/, A1 O JrrJ NJUr- 1 S
J~ wnul ,/ rhr .V,imuul ('um rr ln.nfurr 711 1/ 571 577 I')K3
(Jthrr suppp.rr: NJU,urJl ('anrrr In.uluta. AulrniJn ('JtM:ii Siwt:t1 J1MI rc..Jr.h
Iun.l. ~d tlw I Im.:r.uy ul ('Jkl,/nu.l
M ,)
(tout th. IkpannKut tit N1K-r.+hNrluEs .uiJ ImmwNJ+igy. r+Nl tIN: ('a1Ker Krscrtih
Latxurt.Nt'. Un+sir.uy rN (;+1rhNnrr, ilcrkclcy.
A1111: fIPI.Ii. IMMIIN(UI)t-:NTI('AI. H)RMS OP I'11F.N(>BAKBffAL-INl)UC'lil)
KA'1 1.11'I:K ('Y f(X'iiRUML'S 1'a5(t ARt: i:N('()1)Fa) IiY 1)1: II:KLN-f
mKNAS
Tix w.xl rcp.»1cJ 1><re mwiiv.J in ria., Irunaatian auJrc> u,mg L.mg-livan%
rnJ Huhtm:ui r:rt.. In th+..tuJys onc iuirNry tit l.unl:t:vans rrts czhrbrtrtl.Ntly iytu-
r:hrr,nres P4utb rnJ Pi5(k :rnN+ng Ihc.c uturwrNNt1 uiJ cniymc.: wlxrras, +x+c
iukNry al H.rltinrwn nu w;rs ih:rrai+cnicJ hy iyuahnNrxs P451)h,,.nJ P-4S(!r. A/ter
jittCrKrbachnal rrcrtnnnt, tkP.+ui I++Jy !A1'-mRNA w.s is.+l.ueJ /rrxu thac }rnups nl
rat..rnJ trinslacJ tit rrua. TI>< "SlahckJ puwJuC1s werc rnxuunrN.++IrtcJ wuh .rnlu
INrJy Iu iy1(xhr.Nrk P4511/r uul .rrrr/ytcJ by /wurhnknsNxrdi }cl ck:uaptNNao.
The rc.uQ. rn0u:rtcJ Ih:u 1he pnNluit. synl/ksncJ rn c+rrrl i.xre',tNNN) ra..'tly tu the
(wp P;rnK'uldr Itxrus Ol the en/ynM thrt ihAr:litCR1C hVCr nUCrUSNINI (HNn l':Klr UI
titr.c y:r.)ul» ol rata. It is ctxtclukJ that Jtllercnt slrtu'1ur rl }!cncs crkrN/c thcsc tnr
rtrurKrrcl:rtcJ lunus ul cyuKhrun+c 1'-aSl) aal th+t .+/Cn+hianr lN+u tr rnslrUr+nu! IxrK'
csamg ul thcu P+dypcpuJe PnxluitU tkk. rKN +>liur in wr.,.
Wa/t, F. G.. 1r., V/sul. G. P.. (huiicin.6r, C. J.. Brro+.A. t.' , TMnnas. P. 1:.,
Ry.n. D. L'., and Lcvrn. W.
TheJuunwl ujBad..kwul C'hrrn+.ur.r 2S7t8):1023-4u2A, 19112.
DlMtr srlportu: N:uuxwl In.utuWe+ u( tk.ith anJ the N.uunai Sriertic FrrunJatrun.
frum ttk lkpannKnt ul C'hrnNSuy. Kcnt St:rte Unrven+ty Kent (N1: the Ikpan+uNnt
trt BNK'hcnusrry, tlntvcr.rly ul VernNNN SiMN+I u! Medicine. lSwim}uNi, .uK) the
lkp.anrncnt ul BKKhemrvuy unJ [kug McurM+lan+, Hu/ln+ann-i. RrK'Ik. Ini.. Nut
ky. N1.
BINDIN(; OF Bt.N'LO/u1PYRLNE AND INTRA('ELI.UI.AK TRANSI'OKl' OF
A BOUND I:1.1 C'1'K<)PHU.I(' BI:N'L()/ulPYKI:Nt: MI:1'A13Ut.IT1: BY
LIPOPR()T!~INS
In Ihu hNlihcnHCat atuJy, rKNUUV.knt uptakc ul /'H /bcniu/<c IPYrrrK wus yu rnu-
t.ICJ Itx Irxtrtxrd tulkcleJ Irrmi the dqucnl i+f a IryurJ ihrtNtirtuKr rlsh+i aP+r,tuN+ut
human scruut ya1 w.s fuurN! tu JueaNy i.xrelac Wnh thC htN>{1pNCrn IYNNXUUJINNI
An eleiur>{)hrlrc bcntu/ulPyrenc wctahrdrrc, 111/rrun. 7,i1 JrhyrkrNlNrt 4,/l1 riw+ay
hcnn,lulpyrenc, MxrcuvakMly asxkr.{cJ with luw tknsby hiwryxrxcrm wus tr.tns
/crrcJ tu hunun IymPli.wytcn ur r ruu .uN/lxnrnJ r tJ prci rpuuiik nuikrc x N1. u1 rlK:
IympiNKy/e. s u tunctN+n ul trnrc. licnrrr/u/11yrCik nICr11NJItC hlrMlnll: ta ty/nlrlNll yiC
DNA was rkm.N+str+teJ by nt,am ul ('s('I tknsuy gr:rJrcnt :rn'rlysr.. NrNUrutu}cr+
uruurl.rleJ lyn{ph..J yte. ca1N+sCJ tit very h+w aNKrMr rU.+m u/ ivrruN+gen in Ak Ixc.-
erK'cul l.+w Jl'nsny l+(h+IxtxCMJI'nNNlstr8ll'J 1'II1lhyntrJl+N IrK'tNI11N IUtxi. WUlNWI Ilk
i.NK+Nlttrdnt .NI<hlNNi ul h+w Jl'ns+ty Ir(N+(xtNcln the h+w i.NKTnU,+tNNh.+I iJrirrN.{'fn
JNl rNN uunuLuc /'1111hymNLrKr +nirxlNN:r1uN+. Ovcrall. thr JJta IN..inlyd ikrc wluth
+nJ1iJk' Ih,rt IhCI'1hl1i+K'y Ill iJrl nN/gCNh1nJn11 Iu.x rsWw ruUUn wuh ILIN+pnNr'ru.++
JC17CnJl'rn +Nl h(N.INtNCIn I.NN'C+11r.liNN1, d+C VurFes11vC.+1 .t s+{9//QiJn1 r.+il' I.N hlN.tb.r
tc+ns +n rtN: cdlul.n rnirr.KUou ul hlNydulK i:u.u+N.E.r» wuh bunwu c.lls
lru+1N. 1~. I. rr ul
('ar. tt 10l 111l7 1112 1')1/.
Uthrrsuppvrt: AmcrKVn Canicr S.Ktety.nJ a Nixth 7iRU. Strtc lJnrvcrsrq t-.Wulty
Kcsc.rrih Gnnt
from the (A'nctuc+ C'cntrr. Ikp:rmiN:nt u/ BruN+f+c rl S.rerKe., N.Nth Tes.rs St.rlt
Unrvcrstty. Ikntun.
tiNHAN<'ED VIRAL TRANSFORMATION OF SKIN FIBROBLASTS FKt)M
NLUKI)fIHROMA1'US1S PATII:NTS '
('uUurcJ sl.+n tibn+hlaas ISta trnm Murnt. wuh renu+n .uro.rrmal Jnnunanl
prcranicnws strtes exMhrt rnire.xJ s.n.ruvrty 11) rNKogcnri vuus tr.n./.Nmatrun
( tk rbra IxcuntrJ stNrw tire+KcuncrKC u/ Cnh:uxeJ vrwi tr.nsb+rm,rtN+n ul cultures srl
SF estabbslKd truat prarnts with neurrdrtxunr:rtrrs tNhi In thrs stuJy rultures n/
sAut l+hn+ld.rst, trrrat Iwr.wxrs w+tir rrNl wnlNNrt chmcal NI in Lnulres in whr.h the
J+su(J.r had txrN Jrr}aN+.eJ wcre eAArntned Irrr trrmiorrnas+hty by knslen uwrrnc
saauuw vrru. '11>< vu.t trana~+rniruun results were cunip.rcJ with thusc uhtarrkJ
w+rh SI rt+Uures uutr,rlrJ IitNU c.mlrul. rn I:undrts wntNwr hra.Ky ul iny JraN.kr w nh
rn hcredqxy cuurlNmrrN .r curKcr Thc rewhs ahuw tha A) /+Criem.rl i uhures lurm
P.t{rem. with ihnr.vl Nh were tunshxnxJ. c+NnpureJ with arvcn pcrient u1 iunuul
culturrs. (bUwa rH sArn hhu~f+/a.r> Ir.Nn 1><nrm. N NlKw1 thr il.+..+i al Icrtures ul NF.
hut in lanuhcs +n whK'h the JrsrNJar h,rJ h.cn reiuEnueJ. .lw. e th+bncJ :+ rcl.+rrs:l)
h+}It trausl.xauu.Ni ratc. tirnic 7S Pcrirnt wcre tr.rn,fnrnkJ 1 hrs w+N6 rrKlK ~tr. rh.n
nruruhtxtNiutrnts can hc rrJurkJ .+uNong tdhcr IkrcJrtary J+s.xrkn in whrih rn
h.rnicd tranahN+nab+lrty .rl .uttures tit SF hy :rn.NKUgrnK' vrrv% may tx JruNNislr.rtcJ.
IiKAx-{..+pci. 1' and PrunArl J W.
Aru+uG uJ ('lum tit ruul l.+h,.rruun' Srunrr 13! 1) 27 3_' 1983.
(Other supporr: II.S. i'uhirc Ilcalth Srrvrrc.
hr.un+ Ilu Tan+pa lir.rnih LrtNxanxy lk({rnnkM tit Hcalth anJ Kchrhtht.mvc Sarv-
rics, TrmP.. /1..
1)li(`f. F.X(X'HINIi. AN!> I:NI)X'KlNF. ('UMPONl:NTS OF CUI.IURIiIy
FI:1-Al. M(Hitik 1'AN('KLAS
SuKa rua(arllul.rr uN.rrauai. rtrt) (.r rruuNrunt u+c,ui+n.+j;.+MsI..d rln p.rn-
iuvs, tlx yvuwth tit rt k.tsl three LrrKi% ul eptttirlul iclis. r r..hht. a+nu. l+N/
i:uhu,xuwr u+ tlk .jnK iulturc i.wlJ t>< rmhx6r+N. TiK INrriwr.c ui ttM pahcr pie
slYdrJ hCri' wJS tu rtwr.Ktrnic IurKrav..rlls iuhurcJ uu + p+g.l.to suhstr.rt: rnJ N+
Jrsrnhr t/k ..INUU,J +,ulw+c i+NNt/1NNls 1'.N thrs tudy ,r NN.d 11 'l) ta".IJ\% /M+st
\ul{urrr rINN1K' 10.81 (rA/Nll'J% 1N fdn hn% wa'ra' a'ulturcJ.N+ dK J.+uut su+lxa a.t u++Jr
alr.lp+l;s{.ror..rsuhstr.Nr 1-Ir uWJmuruv.11.N /.Nrl:rrruNau/turri.N+.+st.J.d I.aflc's
Mtmmum Ias.nt+.rl hAd+uUl w11I1 IIN: ,N)Jni.N+ .d IIM4 t>,su+r vrurn. U+i` 11 u+l
msubu.It 25 Nl;.url thN.+y,.Ni. i* tit Nrrul l+sA++s..n+..au. 1tM/ µ' uw/ suiMau rn
p.ut rnhJNtur %.+ 141 ' R1.urupuK %i'INn dK' nNJ+u+u I r: t:.l u)p.ur u+h+hmN .N ,u+.qN+K
IINI i.NnJ11K'J (IN' (iitl'.' INNtINN1Cs. (IN' IN~~L//1 ~IIIIISNr IR{:.NI N.l1C ah'1Il.-ii fl.+lt+'/
2 N+1
.-i
--4
~+Z
t"I
N
R--.
M
wi In culturc I hel\Jller, IfIC l ulWrhf Ci II, CINIIII /NN gr11w JINI survlvl' tln /IK 111ge%ICII
I+tF.Aln Wh.n IO M au.-lulK wJN .rJ.lyd lu IIN' IInr/1uln. rnlylr.i .rllrn-al IUUnI
culturcd icli. JnJ drarucuun ul pl fAltl wcre Irrh/hu.J anuplelay hut prlw tir. c.11.
clwW rw>t grow ur.urvlvcr ln:untrr.r. 11M1 µgrml ..ryhcan 1ryPan Inh/hnlx ur It) ' M
aruprnc fwruuneJ cell pruwth rnJ amylr,c .ccreulMr Irunl the cullurcJ rclnrr rcll..
and prevented the rkarucuun ol plg.kln. l InJcr Ihr:.c:uudulun.L p:nw'rcr..rlls nugrr-
tell rnJ/ur grew fnuu the IxEan hl(.Imtu thc.urla.e ul the pigskin Ikmu. rnJ url:allurlJ
aggregations I1NDN11. HyJn1CIN11wIne wa% nccJrJ lu Pemnt growth Int murc Ihan 2
wk. Glucagon and insulin hrJ rJdlUvc cllecla Light and clcctrun nucruscupli uh.cr-
vatMln] IIMIIc.r1eJ the culture lll rt lC.IN live klMl\ rll cell., r,/., duct, xlnrr, ccn-
troxln:u. crwlucnne, antl nrcxnchynral. The mrplrny uf culturcJ cell% were Juct icll.
anJ xlnar cell.:lhcrc were Itw nlexrkhyntal tclla. Mlnrx Panceaa cclla were cultureJ
fur at least 12 wk by Ihr% mc1MrJ.
Hirata. K.. Uku, T. rrKl Frrrrrwn, A. E.
!n Vuru 1KlH):78N-7y4, lytl..
Ot'btisrpport: National Carxer Institute and the Amencan Cancer S4>tkty.
Front the Center lot Ncuruluglc Study. San Diego. CA.
POPULATION DISTRIHIITION UF PLACENTAL B6NZOtu1PYKL'NE
MtTAii()LISM IN SMOKERS
Hurn:m placental nucruxrmc+ Iwlated from Icnn placcntaa JcrlvcJ Irunl rrnn-
.Imrkmg wrmrcn and wumen.rrwking one tu 40 clguclte. a day were anrlyreJ llx she
nretalx)h.m ul henirMo)pyrenc (BP) mea%ureJ a. various mclahulnc% by high pre..urc
lrqurJ chnrnwwgraphy (HPLC) anJlut a. aryl hyJrucarlwrn hyJruayfa..e ( Allll l aitlv-
sty. Re.ult% aMlw, that AIIH activity wrs several umcs higher In .nwkers thro in
rMm.nruAcn. Regre..urn analym.urr 13 Jlllerenl plxcnlal rl.,uc.lruln wunren.nwlk-
rng lrum rme to dOclgaretlcv rlcrrxm.tratrJ a high rxxrclalum tw lwcen AI11 I:rcuvlt y(n/
the furmalurn uf UP Plrenr)ls resolved by IIPL(1 versus the /nnnaunn ol she pnwar-
clnogenac HP-7,)!-Jnrl. Subscyucn( GituJlc% on placcntaa derived Irum h7 wlutxn wlNl
amukeJ Il) In 4(1 cigarettes Per day Jerrua.tralcda Iklinac Jnc-re.{>rn.e rclaturn.hlP
Jrlx-rc.irln..
between AHH activity nnJ the nutr'rher /rf cigucucs amukeJ/Jay. The
curve was arl:nurlJal tn vhape; M/wever, when the data were pluueJ /xl a.emr log acrlc
the curve a..umcJ a linear .hapc, rexh/ng.aturaurm uf Alil I InJuruun hctwc. n 20 /u
25 r:rtcatette.rday. WMk mean AHH riUvlty was JepcnJcnl ulwn Ihe nuulbcr ul
crgarettea anxrkeJ/Jay, cumrJerabk IntcnnJrvNlual vanabrlny in A1111(raogluy. nuKc
than 1,(1W-fuW In wnrc caxv) was uh.crvcJ anualK IrrJlvrJuals with rlHnlunh(c
xrwrkmg hlvturres In lunher studies. {rlqxllatr.ul J/.tnlwtulrl .uggc.ICJ clustering ut
the pufwlatum in the lnw-AFlH-ainvny region while auJ hilr.l duacyanalc rrwlya.
and twin uuJlea vuggetilcJ that I;cnctr: larl.uv c11n1nhuleJ lu r nla)ou iwrnlun ul she
/nter-u1JlvrJual variability in Alifl xllvlry ub.erveJ anrrNll; snu/kcr..
(.wrr/w,, ll. l.V rr u!.
fnrrrnuuunul Juurnul uf Cuni rr 31(1) 29-37. 1983.
UOther supperr: Naburul In.utulcv ul Ilcalth arlJ the Anlcncan l-arw'cl S/rvcty
FnNll thl' I)l'panlllent UI 1:111ir1111enIJI Ilh'rJlh'utlC~ an1) /irJaC ('Jr1Cl'r I)tu} Cilllil.
Ku.wcll IrrA Mcuulrlal In.htute. ISu11Jlu, aud thc IkP,rnukul uI PrJlrtnc.. llnrvrl
mny ul /'.durarhl S.1ww/l ol McJlrln., Iknvcr
I
'1111 I'KI I'AKAIIr)NOI I 11 IIOM( K'YS'11:INi'.-flllOI.ACI()Ni:IKI'.1:OI'
I':1IM1- I I11ONIN1:
A n..% r1, unplr atlJ Ir.t PnscJurc I/K tcwvcrlnf uM thlunlnrn Irrc l Sihom1M y.
tl'lIM IIIIUIJCIIMN I.-Iluwlng II\ %ynlhCm] /% described In this nrl'Ih1111111uEy (/,111Cr. A
rcl>,-nrJ hclc, rlla ("Slnlclhlo/urx wr..ynlhc.ucJ, she pruJucl was INII:rtcv Ir11111
nlcrlwmulc by t.rklnE Ihc muturc lyl ut 2lM) µl ul ab.ulutc Inethrnul and pII.Inf Ihc
rc.ultrng ..rlulnm un r rulumn containing I nil ul M.C B. dry chruulrulgrrPlruc
alununr. Thc cululun wad c1u1cJ with nlclhanul, anJ the purity u( she Pnslucl wa% then
llill'rllllned by r1111M1 Jcnl rnalyll\. Thin layer ChHrlnatUl(rJ(1hy, wwas used r\ a tiClRpl
nktlwid lu dctcrlmrk it thc .ynthc.ucJ hunwliy.rcrne was mctlnutltnc-Irce Kc+ult.
show that Ihc yield ul thc alununr-culunln PtrnhcJ 1"SiMurKkyacurc 1. 5-IU`6 but.
unlrllnrnUy, rt ProvrJc> r nlcthlrl tur she clwuplcle .eparanon uI 1' S1hunMlcy'.tcurc
rhlulr.'pmc Irum unrcarlcll 1':1/nrethuuunc The rncthnlnlnc 1% held .dlnrgly h) the
rlurruna thuwfh It% carM/AyI gnlup and 1% rww elutcJ by mclhrrMd. Hunwliy.telne
thlulx4NM, hKk111F :r rarlvrxyl E/uup, u clutcd very rapidly. 1'hn raprJ Jnml easy
punhrrnun ul she tluulJrlutx, Ircc ul .:r14, makcA a very cunvcnlcnt Ilrctluil I.H Ilrc
preparation ul u><thuminc-Irce label (ur use in biological .yacm. 'I h/+ raJulacnvc
romPllurMl.hlwlJ hc ul nnpurtant u.e a. a tracer in studying the mrPlmrnt reacu.mv uf
hlrol.><yarlnc with no amMguuy due Io arntamrnalrng mcthrunulc.
Stern. P. 11. 7dich:rnt JO. and Holf/.nun, B.M.
Juurnul u/ Hria hruw'ul urwf &upht.urul Mrrlu.Jt 7:II.l-2q(, 1982
Orhrr srrpport: National InWUute% ul I IeJlth anJ the Un11eJ Canrer Council. Ilx.
Fruln the lkpannknt ul PcJl:unr+. University uf Crllhrrnlr-San Ulcgn, 1-a Jolla.
T111i I'KO1'IiKll1:S 1)I THP. NIiIJTKAi. PROTEINASE RF.I.i'ASEI) BY
I'KIMAKY C'Ht)NI)K(X'YTk Cl1LTUKES AND ffS A("fION ON
PKOI Ii/X;LYI'AN A(i(iKI:GATL
lllc nrcch,un.nl tll Ixul.ugly:rn ialahulom ard It% regulrulHr 1, ul panl.ulrr
Inlcrc.t .Incc it hJ. hcen PruPILCJ that rncrerxJ enrylnalc brcaklbwn ol Ixlwcugly-
can, nuy be Inv.llveJ in u.tclarnhrltls. The Prpcr presented here Je.inhc% the pn.Pcr-
ac. ul the Ixlwcol;ly.an-JcgraJlnl: eniynles rchaxJ rau the e.uxcllular nuhcu by
:Mnalnwylc.ullur.% rlrrl Inolu.c canllagc vl+aclhc type 11 cnll.gcn hur rnrJclcclaAle
tylw I cul/agcn Since Ihc p11 ul she cimxcllular matnx la ar.wrw/ ncutrrht), Jucntum
hrs hcin Iuiu.c4 nn t'IUy11K] .Kllve rt rwWral pit Biugel P-hU cht.NUalu}taphy u(
clnlicnlrrlcJd ullurc ulrAlwn.hnwcd J nurlr PCah rd en/yme ac4vny rwl lx/Nnr}:lyaan
nNaunrlrl cnltalqwJ rn Iw/lyarrylarnrJc hcaJ% a. wcll aa rrn native Prdcuglyi an aKyrc-
I:atr.. lhc cniynlc yields a%f1lYllh' Irlllll tf1/Y%tnMr (re11/111e InNtl Ihe agl;rcgatc ul
rl/(IrnRlOlrk Iy SS,IMN111,11kM~ hhe llQl(tn1y1K Cnlynle Ib IJtent but i Jn hf ri Ilvrlell hy
JIIIIIN/I1lNnyI11MIiurK .KcIrIC 11r Iryfr%111 lhc artrvrt) Iv alr inhibited hy
Idrenvlulcthyl>uII1H1yI IlIMMNIC la pclnlran fwl r. awnpktcly InhlMtcd by a)ptwnrnlbrullnc the
ailivlly 1% remUtill by IAIN ('u IINI~ III IIk INl'%cnCl r11 vrli Iu111lhlUrllle 1 IK ICIiaK UI
such nklrll.qx~d.mr.c by :hullJruiylc. rntu she clitrarcllulrr uulhcu. u. J.uvny rt
12 1 11
l
phyanhol;tral p1f And n, afxhty tu Jrfr.uk nruvc prdco):ly:rn% arc cun.utcn/ wnh a
rok ul the cnry'mr In INrN1:UElyCan nlNt,lhoh.m.
Murales. T. 1. And Aurrmrr, A. E.
Bna'hurur~r rl Hr,,phvarru Ardr 7115:92-1(/1, 19112.
Other srpport: Nalional AnMus Foundation and the Natrunal In.ututcs uf Ilealth.
Fnmt the Ikpanmenta af CkthupeJtc Surgery And Bn><hcmtary. Rush McJtcal Cul-
kKe, C'hlcagu.
TI11: RESISTANCH OF EPITHE:1.lA TO VAS('111.AK1"/.A'fl()N: I'K()TI:INASI:
ANU I:NI)UTHF:1-IAI-CI:1-I.GKOWTH INHIBITOKY ACTIVITII:S IN
URINARY 1f1-ALN)I:R LPITIII:LIUM
The avascular nature uf tr.sues has been NuJreJ cacn.ivcly m a mrKkl Irs.uc,
hyaline cartilahc. Findtngs indicate that the noted ava.culanty uf epolxha may he
attnbutcJ to the presence of an extractabk. low-rrKdecular-waght ixlnr. lbts fachu
amtams fauent mhibitrxs of protertlyuc cntymcs a% well a. a growth infnbuury a.'uvuy
JrrecleJ againal crKk>thehal cells rn vuru. The facrur u er,trx'teJ Irwu the cpuheltum uf
bovine urinary h1aJJen by I M NaCI. The attract i% ultr.rhltcrcJ through an Amtcun
XM-SIl memtxane, then cuncentrateJ and Jlalyted into a 0.9% N.CI .rrlubon using a
UM-2 memlxane. Thu ultrahltratc, ca1kJ the UM-2 rctentate (UM-2K). crmtamS
approsmutely 6 µg protein per gram of tis.ue. Thc UM-2R has a low cunlent uf unHnc
aciJ And is practically JevoKl uf hyJruayprrrlme. SUS-PAGI: reveals that the lIM 2K
consists of sia nulur prntems. The U M-2R contains a Trasy lul -hke prutcma.c inhibitor
that expre»ea strong trypsm rnhtbiktry activity. GwnPariwms between bI.JJer And
serum UM-2Rs amf electruph.xetic mtbdily assays indicate that this prulcma.c inhibi-
tory activity is JenveJ frum the blarkter epllhehurn And na Innn the .erum. 7'hc I IM-
2R ts cytutoatc to cultureJ CndrMhehal cells Cullures ol other cell types (n.xnul And
ncoplastir) are not affected. It seems, therefure, that the bladrkr JcnvcJ fxrnema.e
and enJuthelul cell growth mhrbrrory, actrvnres may protect cptthcha Iruut va.cular
invasion.
Watrkr, H.. Kurunar, K. E. and Puuli- B U.
Tusur 6 Cell 14.657-667. 1HM2.
Other srpport: Natroul Instuutcs of Hcalth.
From the Depanmen(s uf PuMrNrgy. BNrchcmutry And (1nhuPcJrc Surgcry. Ku.h
Presbytcnan-St. Luke's McJrcal Ccnter, Chtcagu.
16 THk KLGUI.ATION OF INVASION BY A CAK771.AGIi-I)IiKIVLI)
ANTTINVASI(>N FACTUR
Tht% ut Jclxh Jocu..um ul nW rcgul.uun u1 urva.wn hy a c+rtila);c-Jruvc.l .rntr
mvairun IaLpK r. JrvKkJ mlu +cvcra/ nuhu .c.brmS rn.ludmg Kcaarn.c ul /MHIINI
candage u. rnv.uum. Su.ccfNththty ul catra.'ICJ:arida);c lu tnvaauu, anJ ('anula);c-
denvcJ antrmvasrve factur. A C'rmclu.uun .ccuun iuntaIn. thc Lrlluwurl; rrb.crva
1-0
~
Inrn. un thc cslxnurntal .cnc% whw'h havc pnwukJ l'vNlCncc Ihat Ilrc rc.rtancc ul"
cartulal't br tuuha 1nv,r.uHr owy INc Jtk lo an c 1trxtabk. hrw-nrrk. ular wctltht /ac HK,
luncbrmally J.hrkJ a. anir-mva.nm lackrr (AIF). Thrs factor amtam. Ihc lulluwtng~
amrmvauvc acuvuk.: (I) PnMetna.e (crdlagcnase) inhibitory aclivny;(2) anb-prulr
Icrauvc And anu-nugratury artivutcs JlrmctcJ against entkxhcbal cell. (antrangnrKcmc ~
xuvny): And / i) lun>trr growth tnhihmiry xtrvny. These acllvttrev occur in the hrw- ~
nwdccular-wctght (1,(MN)>MW<S(l,1MMq Pnncin IractKrn uf a I M NaCI-csuact .uf U
hyalmc.anilagc ra, a..hown only recently, in cMmJrucytc culwres caahlnhcJ /urm
hovirk articular canriagc. They may wcll xt a% local regulators kx suntc of the maprr
mechantaic pathways by which tumor ccll% are thrwght to invnk hu.t a..uc% and ~
mctaaasuc tu Jutant sue.. namely by matna-rkgraJtng enrymes And mcrcavJ tir'o-
nnNum. Al.u, they may inhibit tunwir neuvascul.utta/Km and cuntrul Iuia1 tumrx
growth.
Pauh, 11. lJ. And Knrrrnrr, K. t.
In: Lanta. 1.. A And Ilan, I. K. (cJa. ): Twnwrr lnrwum und Mrruuu.+u. The Haguc:
Maninu. Nr/hull I'ubluhcn, 1982. pp. 267-2'Al.
Other srrpport: National Ins(nutei (if Health.
Frum Ihe Ikpanment of Bukhemntry, Rush-Presbytcnan-St. Luke's MeJtcal Ccnter,
Chicago.
.
VASC UI-ARII-Y OF CARTILAGE
Thrs t>,«r{, chaptcr t% a review of thc literature on the sprclal rnatomr:.l rrwwluuro.
ul the rartUla);c bhsrl .ul)ply And Ihc mcchanr.m. thad Prutccl aJult .antlagc rnatrrt
Irum PCrkttauun by va.cular cnrhNhchum The PenchorwJnal hhaKl .upPly, .:uulrKe
canal., thc }ruwth plarc And arucular candage are all surveyed in this seclwm of the
chaIMCr, while nkcham.m. ul Ihc resutan.c uf candage matncc% to vascular mva.Nm
And the re.ularwe r-f candage lu tunwu cell rnva.urn are Jrx'usseJ lully in rnhcr
+ccurm. In .wnurAry, the cun.lu.nm. JrAwn .rt the erwl uf thi. Papet rnJrc atc that thc
rc.i.r4n.'c rd c.ud_~c to V.1N'ular a/M/ IunMrr invasion 114y bl' duc /U an (Ylrallahlc hlw-
uwdccular-wciEhl Ixlur IurMnun.rlly JcAncJ a. uurmvaswm (xIrK (AIF) Thu lartrrc
can hc cr,tr:w'tcJ Irum uncalcdieJ hyalmc cartilage or Irrxn cultures ul huvme anrcular
clwawJnw'ytei by wdJ.,Jt .rduturnt. 7-Ih hW1UgKJI KIIv1tK% of (he %ah c4lracl- ]IN'h a\
{x,ncrna.c mhrbnnm And cmhNhclal cell gnrwth mhrbnnm, arc prc.cro in a Ix.acrn
Irxuun Ihat ha. a uwrkculrr wcrKht rN bc twecn I,OIMI anJ SO,(XIU. llte.e .wtU.nbc. nwy
cw't r. Lhal rCguIJhN\ I1K MInM UI Ihl' nIJ11K nl[chanl.lpc PatllWay\ by WIII\11 \'nJ1nhC-
hrl .rll. And IunMU ccII% mrNk Iwr.l bsuc., by nutna-JegraJmg .niymc. And by
uw-rar.cJ I>ruhlcrauun arMl mrl:ratum
Kurrurrr. A' f. rIal H. (I
In I lall. It K Ird 1 l'urrdu,rr. New YurA Ac,nlrmw Prc... 141(?. vol I. inr 'X1- i1'
(lrhrr sappurr: NarnHtal Iu.ututc% ul I Ic,Jlh
1'ruiu I1k 1)cp.rnuwaN u1 Ilu01cuwotry arM/ l'athrd1-fy, Ku.h Prc.hytcn.ro Sl I uAc'.
MrJIcrl ('cnlci. ('hIc a);o
Iti
\la'AKAIIONO1 A MIIKINI. 1.1a11.I:M1A VIKU\ I'Kllll'IN7:INASI:
A('17VI11' 1 Kt)M I111'rAS- 1:IN 1(IUtiI-KAfI: AFf1:K
UNA('I:LI.I ILl )JL (I IKl )MA'l ( KiKAP11Y
I7n /nurlnc IculclnrJ viru\ IMuLVI-J..ucIJIcJ prnlrin LInJ\c :n'Uvhy has rc-
ccnlly h.cn IuunJ. tn nrru. lu prcJonunrndy pM/a)hNq IJIC PrhS+, a vlru. prlNCln
present in r.latlvcly>nlJll anxNmt\ in pJnlJliy punhcd varu\ prcp.IrJU.un. Other vlru%
prulcm\. .uih .1\ pK/ Pr27'+ and Pr11Y-, :uc JI\u pMr.ph.NylatrJ in nu,/. but gu a
ks.er tkgrce. Punhentxlre, whcn tnu11aturc:nrlr whpartlacs which are cnhrn.cJ in
P65-are prepared frunt vlnuns by Scpharu+c dli e.clu+lun rulumn ihromatuy:rJidly,
ablwt S(Ir.f nI the Illn:rK :KtIv1Iy la\ J\%:IyeJ with the e7rtll;l'rhNh \uhllrJte plxuvrulnl
rcnwins a....><weJ with the rures. In lhls paper. it ts repnrteJ that iMm cnrea.\IwlateJ
acuvity 1% dlalmt Irunl 1k05'+a(kc it cao be xparat(J Irurn PrtrS- by chrumatnEraphy
un denaturcd ONA-ccllulrne columns IulhrweJ by ccmnlugaulNl ul the (F2 nrNJC'I.
eluleJ Ir7l'tNN1. Under these l'nndllnM\, PrtrSY+ is (kllcled while the Alna\c .rruvlty.
which can pM)\phurylale MNh crlrfagenrlu. IMuLV I'rb5'+ anJ plt)1 Js well a% c.ufc
nrxu IpMrvtunl wbatrrtea. rerrulns in the .upcmalanl. Inlcrc.nngly. wiKn thc
anMrunl ol PrtrtS+ is rcduccd. aa in such prcparatum.. pll) then bc.uak% nulrc heavily
phoapMKylatcd.
Yuahln:du. Y.. Shamca, R. and LuJug, R. B.
Jrwrnul ulGrnrrul Vlrulugy bt:9S-K12, 1911).
(NArr sopport: Naalural Cancer In.dtute and Guvemrrxnt of Japan 1 Y. Y. ).
From Ihe Ikpanmenl of Mlcrnb/ulugy and Immunulugy. University uf tiauh ('Jruhna
Scharl ul Mcdlclne, Culurnbra.
PARAVfRTEI3KAL MAI.I(:NANT KIIAIi1X)11) TUMOR IN INFANCY: IN
V1TR0 STUUILS OF A FAMILIAL TUMOR
F.x the study preaenled here, medlcal.nJ gencuc evaluJruut waa pcrllxnleJ on J
kindred in which twu femak slblings dred within thrce muntha alter prcxnung with
paravenebral hulxrn in the hnt year uf life. Tbe pathukrgy ul the two tulllur% was
Idenllcal and charactenslrc ul a mallgnaM rhatNinld tumor. Thcre were no Irknutt:rble
tumur pattcrna within the krndreJ which have bccn a.xrcialcd with any hcredu.rry
cancer ur prccancer syakomea. Flbnrbluts were Cultured fnrm skin bulalea ntxalneJ
frum the aecuaJ patrenl and Iruth parent. Asaays //f growth k/ncrrra aa.rwlJteJ with
cellular tranafumralrwr rcvealed that bbrubla..ta /rum the al/ecteJ albling can be dra/n-
guuhed from thuse of the parenta and age-matched caluul% by utcreaxJ in 1rrru
uccurrence of Ielraplrruly. Such evrdence .uggests that In.re.xd in vuro Ictrrpluldy
rKcumng spuMancuualy In cultured hbrnblJ.u 1\ .n caprc.\uul u/ . ranrrr-pr1uN:
gene. Incrcastrf rn wrru tetraphrlJy haa prevunraly bccn dcnM.nurateJ in wmn LlndreJ.
with heritable culrxt cancer ayndr.rrnca, and it nuy cstend understanding ul the genctlr
clwlogy of wnrc chlldhrruJ t:ancen.
Lvni h, fl T er ul.
Cunrrr 52:2911-296, N114 l.
Other snpport: NaululJl ('anrcr In\Inulc, 1)Jnc. M.Jlcal Krxal.h IunJ ('urlnll
linlvcrauy Medical C'ulkgc .IIJ the Lcnwrray FlwndunNl.
FnNn Ihc Ikpanmcru ul Nrcvcnuve McJlclnc.nJ Public Hcddl, ('rclghtun (Iluvcr.uy
~
,--(
ti, hlyd ..l Mr,L11/K, t)/11JAJ: IIN' I)\'lIJn11N'lll ul I'cJIJlr11 \, Ihvl\lun nl I I.mJllJu}y- CZ
thh:oluy:y, IINr 1>.LJ11unn1 4.1 I',Illl.dllpy J/wi lhc (IIpxullcnt nl Slu:.ly. 1)1.1\luu ol
-vo.{
1'.JlJUIi 1u11'~ly K.unl>,Iw llrhl~\Jnrl('h1lJ/rn\IIn.p//.Jul llnlvc/\ny Iln\INWI\ul
('IrvcIJ11J ('Jw W..Icln Kc+rrvc Unrvcr.uy S.hlNll ul Mcdlulrc, CkvrlJnJ. JnJ the
~
laprnmcnt.ul Mcdlanc, C'nrncll Unlvcr\Ny McJmal ('ullegc, Ncw YurA ~
A KI:VIIiW OF IIIiKIa)I'CAKY MAI.I(iNAN'I MhLANOMA IN('1.1I1)IN(i
1)Il)MAKKI:KJ IN t-AMILIAI. ATYPIC'AI. MUI:rIP1.L- MOLL MLLANOMA
5YN1)KOMli
MJllgnant Incl'rnnma which u\JIJ lu havc t>ten described by Ifipfxocr.rtc% whn
wJ\ Ihe hr\I lu rcco}nric /tb oullgn.rnt IxNrnUal, ha..huwn an Inrrea\Ing /r1.IJ.nce
dunnE Ihe pJ\t \cvcrrl JecaJr:.. There are .cveral varieties UI Ih/\ .IrKll'lll dIMaK
.Ixlrahc J% well J\ I:cnctlt. JnJ in the hcrcdu:rry vartetle% ol nwllglunl nx:IJ/lrma
cxlxe\.uNl ulJy dlll.r .Ignlh.antly, 'I-lu. In-dcfwh review pruvlJe. J aumlxchcnvlve
cuvcrlaEe ul hcrcJllary ouhgn:rnl u1.IJmNnJ with emphJ\I% ulxm n% hclcruEcneny a\
well a% newly rkvchlpcd hionlarAcr mve\u}.uon\. Thc arcn/ly described Ianulul
alyplrJl nlultuplc nhrlc nlclJmNlla IFAMMMI>yndrurne n IcJlurcJ PJnrculu ancn-
aun hJ\ been given to hrr)Ing\ uf ulrrcJ.cJ hyprrdlphndy rlh.crvcd .\ Jn in 1'rrru
p11e1Nlnlcnun in cultured .LIn hbarblJ\t\ Inrnt hlghn.M and FAMMM-allcctcJ \ub-
Jccl.. 'fhc FAMMM gcnrNype I% runlpks in that it preJl\pux.. pJUCnI mN I/nly tu
nlclanl urta Icutanclw\ :rnd Inlraw uLrr nullKnant melanlNrta) bul also lo r llher hl.luluglr
vanrllcs uf ranr.r. Inrludrng rancl.r rrl the lunl;, panrrea., and bre.Ul. AIIanInM 1\
given to cJnCcr +urrveilll/nie and n1:lnnFenN:n1 pruj!r;1111\ IUr prtKnl\ at /rKrCJKJ rl\f,
Iur the .everJl lurnl. nl' hercdll:uy Irulll;n:rnl melanonu This JppraJrh rrpllahre.
:rdv:rulaErlw.ly uprxl clupluynlcnl nf a hnuwkdgc of gcnclw'\ and hcredltwry, c.rrlrcr
\ynJrU11M IJl'111111i.IlItN1 with panKular :IltenINN1 to tullMlr a)Nx:IJtNM\.
1.cnl lr 11. 1'. rr .rl.
('Irurrr (:rrrrra .1 unJ ('ctuArnrrn s 8.l?S- {S){. iVl/ l.
Other swpport: National Canccr In.tltute arwl the Nebrraa DIva1.N1 ul the FrJtcrn.d
Order uf liaglc..
1rum the IkpJnnlenr ul' Preventive McJlclnc anJ Public HcJllh lhc Ikprnnlcm nl
Ikrnuluhrgy and liny. 'fuwn In./ltule I.u COGnnwnlcJtlorl Ih\nrJ.r\ 10 ('h1lJrrn,
('re/phpln llruvcnuy tirlxMJ uf M.Jlrlne: llnrver.rty ol Nebra.LJ M..h.al Crnl.r
(1u1JhJ anJ the l.Jtxurlury ul ('cIl lirulagy, ('unlcll Unrv.nlty McJlc.rl Culkg. N. w
YurA.
GI:NIi'fl('S OP TKANSPLA('I:NTAI-I.Y INUU('kD 71:RAT(X;I:NIC ANI)
('AK('IN(X&NI(' 1:1 I 1:("1'1 IN KAI3HITti'1'RI:AThI) WI-ffl
N-NI 1 K( ).1( )-N-I:TI IYI.I IKI:A
111 Ih1\ }.Ilru: .nrJy. prrgo.lu1 /J1dat\ u1 rhrcc pJltlJlly Inh1.J .uJUI\. Vv1I'1.
IIIVOr1,Jlwl XA.r11JpJlu.nlwI IIIVI)r1.N N'li JulJl.\w:l. }1..ulpluh~Uun.u1
ralnlE ul N-rolr.-\u-N .rllvlu/cJ tNI 111J/\\.dv.d ru unr'tJn.NU "u JJ.. IK ul fc.truun
(N'IN'IN .IIIII'Ir'Ih1'\ 111 IUIIMN U\~\INIh1I111 hlwl'1'n \Ir./ln\ WII J(I11w IIIIIhN IIN1
Jt'INI' \{1J/111 .IIh1 IIIVtIJJ /hl~h-11111hN111CN/CIKI' \t/J111) IIJ\C hv.'u .knN~u\u.u.J Iw
11.1 UI ?? WIr J x 111VOrJ hylxlJ lurl}ruy wrJnc.l 17/kv:ll~lx,1 pruu./n IrnJl
Iu11hN\JtJhIxU\IIIWIcIyllvl'/INN1tI1\UIJ)'i t)111l11VlYJ - W111hyMl.llu~~}cny
{--~
U
m
