Council for Tobacco Research
Report of the Council for Tobacco Research-U.S.A., Inc. [St]
Abstract
MAR
Fields
- Depository Date
- 25 Sep 1995
- Master ID
- Ctrmn00000667-6967
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- CTRMN000828-0848 by-Laws of the Council for Tobacco Research - U.S.A., Inc. [Rules and Regulations for the Operation of the Council]
- CTRMN000849-0854 Application for Research Grant [A Blank Funding Request Form for Scientific Studies]
- CTRMN000855-0856 Statement of Policy Containing Conditions and Terms Under Which Project Grants Are Made [Stipulations for Receiving A Funding Award]
- CTRMN000857-0859 [Suggestions and Guidelines for Submitting A Request for A Grant]
- CTRMN000860-0871 [Transmittal of Information for Securing A Research Grant]
- CTRMN000872-0882 [A Blank Funding Request Form for Scientific Studies]
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- CTRMN001046-1094 1957 Report of the Scientific Director [St]
- CTRMN001095-1127 1958 Report of the Scientific Director [St]
- CTRMN001128-1163 1959 Report of the Scientific Director [St]
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- CTRMN001270-1306 Annual Report of the Scientific Director [St]
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- CTRMN001430-1485 Annual Report of the Scientific Director [St]
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- CTRMN001530-1578 Annual Report of the Council for Tobacco Research-U.S.A., Inc. [St]
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- CTRMN001633-1681 Report of the Council for Tobacco Research-U.S.A., Inc. [St]
- CTRMN001682-1727 Report of the Council for Tobacco Research-U.S.A., Inc. [St]
- CTRMN001728-1771 1975 Report of the Council for Tobacco Research-U.S.A., Inc. [St]
- CTRMN001772-1816 Report of the Council for Tobacco Research-U.S.A., Inc. [St]
- CTRMN001817-1860 1977 Report of the Council for Tobacco Research-U.S.A., Inc. [St]
- CTRMN001861-1913 Report of the Council for Tobacco Research-U.S.A., Inc. [St]
- CTRMN001914-1967 1979 Report of the Council for Tobacco Research-U.S.A., Inc. [St]
- CTRMN001968-2025 1980 Report of the Council for Tobacco Research-U.S.A., Inc. [St]
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- CTRMN002149-2223 Report of the Council for Tobacco Research-U.S.A., Inc. [St]
- CTRMN002224-2942 Application for Research Grant An Investigation of the Spectral and Chromatographic Characteristics of Aromatic Hydrocarbons. [Study on High Temperature Gas-Liquid Partition Chromatography]
- CTRMN002943-3303 [Regarding Polio and Tuberculosis As Predisposing Factor in Lung Cancer]
- CTRMN003304-3322 Tobacco-Health Research Program [Display Case Showing Main Areas of Investigation]
- CTRMN003323-3326 Statement of Policy Containing Conditions and Terms Under Which Project Grants Are Made [Rules for Approval of Grants Relating to Tobacco Use and Human Health]
- CTRMN003327-3337 A Brief Review of the Smoking-Lung Cancer Theory [Concerning Problems of Cigarette Lung Cancer Causation and Why They Have No Been Solved]
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- CTRMN003358-3365 Some Information About... The Council for Tobacco Research-U.S.A., Inc. ...and Its Research Program [Informs About the Purpose and Function of Organization's Research Program]
- CTRMN003366-3374 the Research Program of the Scientific Advisory Board to the Council for Tobacco Research - U.S.A. [Informs the Purposes, Policies, and the Research Program of the Board]
- CTRMN003375-3419 the Cancer-Smoking Controversy [Regards the Fallacious Conclusions of Cigarette Smoking Causing Lung Cancer From A Mathematical and Scientific Point of View]
- CTRMN003420-3425 Some Harvard Men & the Smoking Habit [Give Results of Questionnaire Relating to Biological Factors of Tobacco Smoking]
- CTRMN003426-3431 the Pathologic Anatomy of the Bronchial Tree and Lungs Reprinted From the Archives of Pathology Vol. 70 [St Finds of Equivocal Results with the Use of Tobacco]
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- CTRMN003438-3442 Some Statistical Observations on A Cooperative Study of Human Pulmonary Pathology, II [Results Show Pathological Lungs in Different Cities Are Acutally Different]
- CTRMN003443-3447 Some Statistical Observations on A Cooperative Study of Human Pulmonary Pathology. II [Study Comparing Pathological Conditions in 8 Different Cities Shows That Conditions Are All Different]
- CTRMN003448-3456 Some Statistical Observations on A Cooperative Study of Human Pulmonary Pathology [Systematic Examinations of the Conditions at Autopsy in the Bronchial Mucosae of Run-of-the-Mill Cases]
- CTRMN003457-3464 Some Statistical Observations on A Cooperative Study of Human Pulmonary Pathology III [When Probability Is Doubtful the Use of Variable Tables to Calculate Results Is the Best Way to Make A Precise and Accurate Answer for Sufficient Range of Pathological Conditions]
- CTRMN003465-3476 Differences Between Smokers and Nonsmokers [Differences Between Smokers and Nonsmokers Have to Do with Personality Traits and Physiologic Criteria]
- CTRMN003477-3485 the Psychology of Smoking [Smoking Is Determined by Certain Personality Variables and Personal Needs]
- CTRMN003486-3490 the Tobacco and Health Research Program of the Scientific Advisory Board [Regarding Information the Tobacco Industry Research Committee Do for the Research Program]
- CTRMN003491-3558 Tobacco Consumption in Various Countries [Results of Cigarette and Cigar Smokers From Different Countries]
- CTRMN003559-3560 Statement of Policy Containing Conditions and Terms Under Which Project Grants Are Made [Guidelines for Which Grants Are Approved]
- CTRMN003561-3780 Tobacco Smoking in the United States in Relation to Income Marketing Research Report No. 189 [A Report Compiled by the Bureau of the Census for the United States Public Health Service on Smoking Characteristics in Relation to Income, Age, Region, Urban-Rural Residence and Occupation.]
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- CTRMN003784-3787 Confidential Report on Meeting January 18, 1954 Tobacco Industry Research Committee (TIRC) [St]
- CTRMN003788-3797 Confidential Report on Meeting March 15, 1954 Tobacco Industry Research Committee [St]
- CTRMN003798-3800 Tobacco Industry Research Committee Meeting [St]
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- CTRMN003816-3835 Tobacco Industry Research Committee Meeting [St]
- CTRMN003836-3852 Tobacco Industry Research Committee Meeting November 3, 1955 [St]
- CTRMN003853-3869 Tobacco Industry Research Committee Meeting February 14, 1956 [St]
- CTRMN003870-3895 Tobacco Industry Research Committee Meeting October 9, 1956 [St]
- CTRMN003896-3907 Tobacco Industry Research Committee Meeting May 9, 1957 [St]
- CTRMN003908-3923 Tobacco Industry Research Committee Meeting November 8, 1957 [St]
- CTRMN003924-3931 Tobacco Industry Research Committee Meeting May 8 1958 [St]
- CTRMN003932-3939 Tobacco Industry Research Committee Meeting November 6, 1958 [St]
- CTRMN003940-3945 Tobacco Industry Research Committee Meeting [St]
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- CTRMN003983-3991 Tobacco Industry Research Committee Meeting [St]
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- CTRMN004053-4057 Minutes of of the Board of Directors January 28, 1972 [St]
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- CTRMN004142-4147 Minutes of the Special Meeting of the Board of Directors December 10, 1975 [St]
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- CTRMN004158-4161 Minutes of the Meeting of the Board of Directors January 28 1977 [St]
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- CTRMN004168-4172 Minutes of the Meeting of the Board of Directors January 29, 1979 [St]
- CTRMN004173-4176 Minutes of the Meeting of the Board of Directors February 1, 1980 [St]
- CTRMN004177-4178 Minutes of the Board of Directors Executive Committee Meeting New York, New York [St]
- CTRMN004179-4184 Minutes of the Meeting of the Directors January 30, 1981 [St]
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- CTRMN004405-4409 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004410-4413 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004414-4416 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004417-4420 Confidential Report Scientific Advisory Board Meeting [St]
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- CTRMN004434-4436 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004437-4439 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004440-4443 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004444-4446 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004447-4450 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004451-4454 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004455-4459 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004460-4463 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004464-4467 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004468-4472 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004473-4475 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004476-4480 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004481-4484 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004485-4492 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004493-4497 Confidential Report Scientific Advisory Board Meeting September 23-24, 1967 [St]
- CTRMN004498-4501 Confidential Report Scientific Advisory Board Meeting December 9-10, 1967 [St]
- CTRMN004502-4505 Confidential Report Scientific Advisory Board Meeting [St]
- CTRMN004506-4510 Confidential Report Scientific Advisory Board Meeting La Jolla, California March 2-3-4, 1968 [St]
- CTRMN004511-4516 Confidential Report Scientific Advisory Board Meeting New York New York May 25-26, 1968 [St]
- CTRMN004517-4522 Confidential Report Scientific Advisory Board Meeting New York, New York September 14-15, 1968 [St]
- CTRMN004523-4526 Confidential Report Scientific Advisory Board Meeting New York, New York December 8-9, 1968 [St]
- CTRMN004527-4531 Confidential Report Scientific Advisory Board Meeting New York, New York March 22-23, 1969 [St]
- CTRMN004532-4538 Confidential Report Scientific Advisory Board Meeting New York, New York May 16-18, 1969 [St]
- CTRMN004539-4544 Confidential Report Scientific Advisory Board Meeting New York, New York September 12-14, 1969 [St]
- CTRMN004545-4549 Confidential Report Scientific Advisory Board Meeting New York, New York December 12-14, 1969 [St]
- CTRMN004550-4555 Confidential Report Scientific Advisory Board Meeting Colorado Springs, Colorado March 20-22, 1970 [St]
- CTRMN004556-4560 Confidential Report Scientific Advisory Board Meeting New York, New York [St]
- CTRMN004561-4569 Confidential Report Scientific Advisory Board Meeting New York, N.Y. September 18-19-20, 1970 [St]
- CTRMN004570-4578 Confidential Report Scientific Advisory Board Meeting Chicago, Illinois January 15,16, 1971 [St]
- CTRMN004579-4585 Confidential Report Scientific Advisory Board Meeting New York, N.Y. May 7-8-9, 1971 [St]
- CTRMN004586-4593 Confidential Report Scientific Advisory Board Meeting New York, N.Y. September 24-25-26, 1971 [St]
- CTRMN004594-4598 Confidential Report Scientific Advisory Board Meeting New York, N.Y. [St]
- CTRMN004599-4604 Confidential Report Scientific Advisory Board Meeting Palm Springs, California March 24-25-26, 1972 [St]
- CTRMN004605-4609 Confidential Report Scientific Advisory Board Meeting New York, New York June 9-11, 1972 [St]
- CTRMN004610-4614 Confidential Report Scientific Advisory Board Meeting New York, New York September 15-17, 1972 [St]
- CTRMN004615-4623 Confidential Report Scientific Advisory Board Meeting New York, New York March 14-15-16, 1973 [St]
- CTRMN004624-4626 Meeting Executive Committee of the Scientific Advisory Board June 13, 1973 New York, N.Y. [St]
- CTRMN004627-4634 Confidential Report Scientific Advisory Board Meeting New York, New York October 10-11-12, 1973 [St]
- CTRMN004635-4643 Meeting Executive Committee of the Scientific Advisory Board December 4, 1973 New York, N.Y. [St]
- CTRMN004644-4654 Confidential Report Scientific Advisory Board Meeting New York, New York October 30-31 November 1, 1974 [St]
- CTRMN004655-4656 Meeting Executive Committee of the Scientific Advisory Board December 13, 1974 New York, N.Y. [St]
- CTRMN004657-4664 Confidential Report Scientific Advisory Board Meeting Santa Barbara, California March 26-27-28, 1975 [St]
- CTRMN004665-4672 Confidential Report Scientific Advisory Board Meeting New York, New York September 10-11-12, 1975 [St]
- CTRMN004673-4675 Meeting Executive Committee of the Scientific Advisory Board New York, New York December 13, 1975 [St]
- CTRMN004676-4683 Confidential Report Scientific Advisory Board Meeting Santa Barbara, California March 17-18-19, 1976 [St]
- CTRMN004684-4686 Meeting of the Executive Committee of the Scientific Advisory Board New York, New York June 11, 1976 [St]
- CTRMN004687-4694 Confidential Report Scientific Advisory Board Meeting New York, New York September 28-29-30, 1976 October 1, 1976 [St]
- CTRMN004695-4697 Meeting of the Executive Committee of the Scientific Advisory Board Bethesda, Maryland December 1, 1976 [St]
- CTRMN004698-4706 Confidential Report Scientific Advisory Board Meeting Tuscon, Arizona March 23-25, 1977 [St]
- CTRMN004707-4708 Meeting of the Executive Committee of the Scientific Advisory Board Tuscon, Arizona March 25, 1977 [St]
- CTRMN004709-4710 Meeting of the Executive Committee of the Scientific Advisory Board New York, New York May 19, 1977 [St]
- CTRMN004711-4719 Confidential Report Scientific Advisory Board Meeting New York, New York October 26-28, 1977 [St]
- CTRMN004720-4723 Confidential Report Scientific Advisory Board Meeting Phoenix, Arizona January 16-17, 1978 [St]
- CTRMN004724-4724 Confidential Report Meeting of the Scientific Advisory Board Committee Phoenix, Arizona January 17, 1978 [St]
- CTRMN004725-4734 Confidential Report Scientific Advisory Board Meeting New York, New York April 26-27-28, 1978 [St]
- CTRMN004735-4735 Confidential Report Scientific Advisory Board Executive Committee New York, New York April 27, 1978 [St]
- CTRMN004736-4737 Confidential Report Meeting for the Scientific Advisory Board New York, New York July 27, 1978 [St]
- CTRMN004736A-4736A Confidential Report Meeting of the Scientific Advisory Board New York, New York July 27, 1978 [St]
- CTRMN004738-4747 Confidential Report Scientific Advisory Board Meeting New York, New York October 18-19-20, 1978 [St]
- CTRMN004748-4750 Confidential Report Meeting of the Scientific Advisory Board New York, New York December 20, 1978 [St]
- CTRMN004751-4759 Confidential Report Scientific Advisory Board Meeting New York, New York April 11-12-13, 1979 [St]
- CTRMN004760-4769 Confidential Report Scientific Advisory Board Meeting New York, New York October 17-18-19, 1979 [St]
- CTRMN004770-4770 Confidential Meeting of the Report Scientific Advisory Board New York, New York October 18, 1979 [St]
- CTRMN004771-4780 Confidential Report Scientific Advisory Meeting New York, New York Aprill 9-10-11, 1980 [St]
- CTRMN004781-4781 Confidential Report Executive Committee of the Scientific Advisory Board Meeting New York, New York June 20, 1980 [St]
- CTRMN004782-4783 Confidential Report Executive Committee of the Scientific Advisory Board Meeting New York, New York September 16, 1980 [St]
- CTRMN004784-4792 Confidential Report Scientific Advisory Board Meeting New York, New York October 8-9-10, 1980 [St]
- CTRMN004793-4794 Confidential Report Meeting of the Scientific Advisory Board New York, New York October 9, 1980 [St]
- CTRMN004795-4804 Confidential Report Scientific Advisory Board Meeting New York, New York April 8-9-10, 1981 [St]
- CTRMN004805-4805 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board New York, New York April 8, 1981 [St]
- CTRMN004806-4806 Confidential Report Meeting of the Scientific Advisory Board New York, New York September 10, 1981 [St]
- CTRMN004807-4816 Confidential Report Scientific Advisory Board Meeting New York, New York October 14-15-16, 1981 [St]
- CTRMN004817-4818 Confidential Report Meeting of the Executive Committee Scientific Advisory Board New York, New York October 15, 1981 [St]
- CTRMN004819-4820 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board New York, New York December 9, 1981 [St]
- CTRMN004821-4831 Confidential Report Scientific Advisory Board Meeting New York, New York April 21, 22, 23, 1982 [St]
- CTRMN004832-4833 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board New York, New York June 21, 1982 [St]
- CTRMN004834-4843 Confidential Report Scientific Advisory Board Meeting New York, New York October 6,7,8, 1982 [St]
- CTRMN004844-4844 Confidential Report Meeting of the Executive Meeting of the Scientific Advisory Board New York, New York October 8, 1982 [St]
- CTRMN004845-4845 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board Scottsdale, Arizona February 24, 1983 [St]
- CTRMN004846-4857 Confidential Report Scientific Advisory Board Meeting New York, New York April 20, 21, 22, 1983 [St]
- CTRMN004858-4858 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board New York, New York April 22, 1983 [St]
- CTRMN004859-4859 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board New York, New York June 6, 1983 [St]
- CTRMN004860-4871 Confidential Report Scientific Advisory Board Meeting New York, New York October 12, 13, 14, 1983 [St]
- CTRMN004872-4882 Confidential Report Scientific Advisory Board Meeting New York, New York March 28, 29, 30, 1984 [St]
- CTRMN004883-4883 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board New York, New York March 29, 1984 [St]
- CTRMN004884-4895 Confidential Report Scientific Advisory Board Meeting September 19, 20, 21, 1984 New York, New York [St]
- CTRMN004896-4896 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board New York, New York September 20, 1984 [St]
- CTRMN004897-4897 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board Palm Beach, Florida February 25, 1985 [St]
- CTRMN004898-4898 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board New York, New York April 16, 1985 [St]
- CTRMN004899-4910 Confidential Report Scientific Advisory Board Meeting April 15, 16, 17, 1985 New York, New York [St]
- CTRMN004911-4911 Confidential Report Meeting of the Executive Committee of the Scientific Advisory Board New York, New York April 16, 1985 [St]
- CTRMN004912-4923 Confidential Report Scientific Advisory Board Meeting April 15, 16, 17, 1985 New York, New York [St]
- CTRMN004924-4927 for Release: A.M.'s Wednesday, April 14, 1954 ["Reaction to the Compendium "A Scientific Perspective on the Cigarette Controversy""]
- CTRMN004928-4929 for Release: A.M.'s Tuesday, April 27, 1954 [Scientific Advisory Board Organized Early to Begin Research Into All Phases of Tobacco Use and Health for the Year]
- CTRMN004930-4931 for Release in A.M.'s of Tuesday, May 18, 1954 [Proposals Submitted for Cancer Research Projects for Consideration by Scientific Advisory Board]
- CTRMN004932-4933 for Release After 10:30 A.M., June 15, 1954 [Appointment of Dr. Clarence Cook Little Announced by the Tobacco Research Industry Committee]
- CTRMN004934-4937 for Immediate Release [American Cancer Society Survey Conveys the Need to Further Research to Discover Cause of Cancer and Cardiovascular Disease]
- CTRMN004938-4939 for Release in Am's of Tuesday, July 20, 1954 [Edwin B. Wilson of Harvard University Became A Member of Scientific Advisory Board of the Tobacco Industry Research Committee]
- CTRMN004940-4942 for Release: A.M.'s of Wednesday, July 28, 1954 Little Announces Research Policy of Tobacco Industry Research Committee [Three Main Areas to Be Covered by Research Program Announced]
- CTRMN004943-4944 for Release in A.M.'s Thursday, August 19, 1954 [Dr. Julius H. Comroe of University of Pennsylvania, Accepted Membership on Scientific Advisory Board of the Tobacco Industry Research Committee]
- CTRMN004945-4945 for Immediate Release (Monday, October 11, 1954) Dr. Little Gives TIRC View [Little States That No Convincing Evidence Has Yet Been Found to Prove That Cigarette Smoking Causes Lung Cancer]
- CTRMN004946-4946 for Immediate Release (Tuesday, October 12, 1954) [Timothy V. Hartnet, Chairman of Board, Stated That Public Should Be Reminded That No Lung Cancer Causing Agent Has Yet Been Identified in Tobacco]
- CTRMN004947-4947 for Release: Wednesday, October 20, 1954 Hartnett Approves Care in Research [Committee to Be Sure That Reliable Evidence Is Available Before Announcing Important Conclusions to the Public About Smoking]
- CTRMN004948-4948 for Immediate Release (Thursday, October 21, 1954) Hartnett Comments on Cigarette Paper Burning [Timothy V. Hartnett Comments That A Cancer Causing Compound on Skin of Mice Has Been Produced by Burning Cigarette Paper Under Certain Lab Conditions]
- CTRMN004949-4952 for Release: A.M.'s, Monday, November 8, 1954 Tobacco Industry Research Committee Announces Initial Grants [Six Scientific Research Grants Totalling Over $82,000 Made Public]
- CTRMN004953-4954 for Release in A.M.'s, Monday, December 6, 1954 Scientific Associate Named by Tobacco Research Group [Robert C. Hockett Appointed As Scientific Director of TIRC to Help Develop Research Into Tobacco Use and Health]
- CTRMN004955-4956 for Immediate Release Cross-Country Lung Study Planned by Tobacco Group [Group of Pathologists Plan A Cooperative Study to Increase Knowledge of Lung Ailments]
- CTRMN004957-4959 for Release in Year-End Editions But Not Before December 27, 1954 Statement by Timothy V. Hartnett, Chairman Tobacco Industry Research Committee [TIRC Will Approve A Quarter of A Million Dollars for Research Into Public Health Problems by the End of 1954]
- CTRMN004960-4963 for Release: Monday A.M.'s, January 17, 1955 Tobacco Industry's New Research Grants Send Total to More Than $300,000 [New Research Grants Announced by TIRC to Relate to Both Human and Animal Scientific Studies]
- CTRMN004964-4966 for Release in A.M.'s of Friday, April 8, 1955 Tobacco Industry Group Votes Medical Research Fellowships [TIRC Announced Fellowship Program to Create Interest in Research Among Medical School Students]
- CTRMN004967-4969 Release Tuesday, May 17, 1955 and Thereafter Tobacco and Health Studies Cover Wide Range of Research [Although No Scientific Proof That Cigarettes or Air Pollution Cause Lung Cancer, Progress Is Being Made to Learn More About Tobacco Use and Health by the TIRC]
- CTRMN004970-4972 Tobacco Research Grants Increased to 490,000 Mark [Research Grants Are Created So Science Can Provide An Answer to Public Health Problems]
- CTRMN004973-4973 Hartnett Comments on Auerbach Paper [Many Studies on Human Lung Tissue, Not Enough Data Available to Draw A Conclusion Yet]
- CTRMN004974-4975 Anti-Smoking Theories Not Based on Complete Scientific Knowledge [Scientific Investigation Into What the Real Effects Are From Tobacco Use]
- CTRMN004976-4977 Hartnett Comments on Statistical Study [Research Intensified in Past Year, No Proof That Smoking Causes Cancer]
- CTRMN004978-4980 Doctor's Survey Termed 'biased, 'says Hartnett [Questionnaire Would Give No Concrete Conclusions About Tobacco Causing Cancer]
- CTRMN004981-4982 Hartnett Alerts Burley Men to Challenge Tobacco Attacks [Doctors Are Expressing Their Doubts About Statements Already Made; Tobacco Effects]
- CTRMN004983-4984 Bright Belt Warehouse Men Told Facts Challenge Critics [Still Looking for Proof That Tobacco Causes Cancer]
- CTRMN004985-4986 Tobacco Spokesman Says Facts and Position Are Unchanged [Various Experiments with Animals Showed That Cancer Was Not the Outcome From Tobacco Smoke]
- CTRMN004987-4987 Hartnett Comments on Statistical Study [Methods Used for Cancer Research Still Do Not Give Enough Information]
- CTRMN004988-4990 British Tobacco Experiments Unable to Induce Cancers [Still No Connection, Tests Will Continue]
- CTRMN004991-4993 Tobacco Research Grants Now Over 838,000 Mark [Tobacco Research Is Getting More Support From Doctors, Scientists, and Educators]
- CTRMN004994-4996 Statement by Timothy V. Hartnett, Chairman Tobacco Industry Research Committee [Summary of the Past Years' Events in Tobacco Research]
- CTRMN004997-4999 Tobacco Research Fund Raised to 1,500,000 [Finding New Ways to Break Down Tobacco]
- CTRMN005000-5001 Tobacco Industry Group Renews Medical Research Fellowships [More Medical Students Are Receiving Fellowships Than Last Year]
- CTRMN005002-5003 Hartnett Statement on Cancer Meeting Reports [There Is Still Much Research to Be Done Before Tobacco Is Linked to Cancer]
- CTRMN005004-5005 [Pathologists From Around the Country Have Studied Human Lung Tissues Over the Past Year]
- CTRMN005006-5006 [Smoking Patterns Do Not Explain Differences in Lung Cancer]
- CTRMN005007-5008 Hartnett Cites British Tobacco Tests Failing to Produce Animal Cancer [the Search for Cancer Must Be Broadened and Intensified]
- CTRMN005009-5010 Hartnett Comments on Statistical Claims [Although Many Believe Smoking Causes Cancer, Scientists Still Have Not Found Any Prof]
- CTRMN005011-5011 [Present Knowledge Doesn't Hint A Relationship Between Smoking and Heart Problems]
- CTRMN005012-5016 Hartnett Comments on Cancer Society Booklet [Pamphlet Omits Some Important Research Results]
- CTRMN005017-5018 Statement by Timothy V. Hartnett, Chairman Tobacco Industry Research Committee [Research Committee Needs More Scientific Investigation]
- CTRMN005019-5025 Tobacco Research Funds Reach 2.2 Million Mark [Over 60 Independent Scientists Throughout the Country Are Working in Institutions to Further the Research of Cancer and Tobacco Use, They Are Listed]
- CTRMN005026-5027 Hartnett Comments on French Report [French Are Reporting Rapid Cancer Formation in Mice, Hartnett Feels It Can't Be Judged on the Basis of New Reports Without Longer Consideration and Careful Analysis]
- CTRMN005028-5030 Harnett Cites Points for Clarification in Tobacco Health Study [Smoking Study Reached the Public's Attention Before It Was Reviewed and Before the Facts Were Made Crystal Clear]
- CTRMN005031-5032 Hartnett Comments on Wynder News Stories [News Story Claims That Assumptions Have Been Made About Mouse Skin Painting Experiments]
- CTRMN005033-5037 Statement on Smoking and Health Studies [Scientists Are Developing A Program for Different Phases of Tobacco Use and Health, Members Listed]
- CTRMN005038-5045 Hartnett Says Statistics Do Not Establish Causes [Studies Are Open to Assumptions and Certain Selection of Subjects]
- CTRMN005046-5048 Hartnett Cites Scientists Doubting Smoking-Cancer Theory [the Surgeon General Believes the Studies Are Missing Essential Facts That Should Be Acknowledged]
- CTRMN005049-5050 Scientist Comments on Benzpyrene Report [Benzpyrane in Tobacco Smoke, Under Investigation for Years Caused Cancer in Lab Animals But Not Humans]
- CTRMN005051-5055 "Cancer Researcher Challenges "Cause and Effect" Charges Against Smoking" [It's Difficult to Have A Cause and Effect Relationship When Dealing with Cancer and Tobacco Use]
- CTRMN005056-5056 [Atlantic Monthly Gives A Misleading Picture of Dr. Little and His Public Position]
- CTRMN005057-5058 Tobacco Committee Chairman Comments on Cancer Society Talk [Many Unresolved Questions About Tobacco Causing Cancer Don't Stop Researching]
- CTRMN005059-5061 Tobacco Research Scientist Discusses Smoking Question [Most Tend to Believe the Anti-Cigarette Theory But It Shouldn't Be Confused with the Facts There's Still Not Enough Facts to Prove That Smoking Causes Cancer]
- CTRMN005062-5062 Hartnett Says Leaflet Admits Differing Opinions on Smoking [Leaflet Tells How Scientists Disagree on Evidence]
- CTRMN005063-5066 Research Program Throws Doubts on Smoking Charges [Incorrect Claims and Harmful Effects From Tobacco]
- CTRMN005067-5069 Statement by Timothy V. Hartnett, Chairman Tobacco Industry Research Committee [More and More Scientists Had Doubts and Disbeliefs in the Charges Against Smoking As A Cause of Cancer]
- CTRMN005070-5071 Tobacco Research Scientist Discusses Smoking Question [Scientists Say Smoking Has Been Proved Guilty When Linked with Human Health Problems]
- CTRMN005072-5072 Pamphlet Merely Review, Dr. Little Says [Opinions Is All the Author Gives in His Pamphlet Scientists Are Still Disputing]
- CTRMN005073-5076 TIRC Fund for Research Boosted to $2,700,000 [Grants for Independent Scientists Interested in Studying Problems of Cancer and Heart Disease When Related to Smoking]
- CTRMN005077-5080 [New Knowledge on Smoking and Health Questions]
- CTRMN005081-5081 [Veterans Study of Smoking Habits]
- CTRMN005082-5082 [Report on How There Was Existing Research Evidence and How It Was Ignored]
- CTRMN005083-5085 [Regarding Anti-Tobacco Movement]
- CTRMN005086-5086 [Benzpyrene in Cigarette Smoke]
- CTRMN005087-5088 [Experimental Evidence Is Weak]
- CTRMN005089-5089 Hartnett Says Article on Arsenic Goes Beyond Facts [Farmers Use of Insecticides with Arsenicals on Growing Tobacco Has Steadily Been Declining]
- CTRMN005090-5091 [Scientists Who Produce Conflicting Results Are Being Ignored by the Health Department]
- CTRMN005092-5094 Statement by Timothy V. Hartnett, Chairman Tobacco Industry Research Committee [Even More Grants Have Been Made Available More Factors Have Been Associated with Lung Cancer]
- CTRMN005095-5100 Tobacco Industry Group Announces Research Grants [Grant Increases to $3,200,000 List of Grants Announced]
- CTRMN005101-5103 Tobacco-Health Research Described in 1958 Report [the Report Talked About Experiments That Were Unable to Produce Cancer and the Cause and Effect Theory]
- CTRMN005104-5104 [Report Shows That Other Factors Besides Smoking Have Been Causing Lung Cancer, But Scientists Do Not Dismiss the Fact That Lung Cancer Is Possibility From Smoking]
- CTRMN005105-5105 [Anti-Smoking Campaign Is Thought to Be A One-Sided Propaganda Effort]
- CTRMN005106-5106 [Questions Arise From on-Sided Study]
- CTRMN005107-5111 Cancer Scientist's Comments on Smoking-Lung Cancer Review [Evidence on Smoking and Lung Cancer Is Accumulating, Among Other Contributing Factors]
- CTRMN005112-5117 [Comments Relating to Observation on Various Studies]
- CTRMN005118-5122 Research Grants Announced by Tobacco Industry Group [$500,000 Was Added to Research Funds, A List of Recipients with the New Grants Is Mentioned]
- CTRMN005123-5127 Research Supported by Tobacco Committee Discussed in Scientific Director's Report [It Seems That Finding An Answer to Lung Cancer and Cardiovascular Diseases Are Too Complicated]
- CTRMN005128-5128 [Attacks on Tobacco, the Lung Cancer Issue Is Still Not Settled]
- CTRMN005129-5129 Nta Stand on Smoking Repeats Opinions [Statement Gives No Evidence and Is Dealing Mainly with Opinions]
- CTRMN005130-5132 Tobacco Research Group Adds New Scientific Associate [New Scientific Director Was Added to the TIRC, Curriculum of J. Morrison Brady]
- CTRMN005133-5134 Tobacco Research Group Cites Questions Raised in Heart Statement [Lack of Evidence Proposes New Questions and Doubts About Cardiovascular Disease]
- CTRMN005135-5137 New Evidence Shows Complexities of Lung Cancer, Scientist Says [Hundreds of Studies Indicate Many Factors Contribute to the Complex Chain That May Result in Lung Cancer, No One Can Figure Out the Right Factor and Still the Reported Lung Cancer Cases Are Rising]
- CTRMN005138-5140 New Grants to Scientists Made by Tobacco Research Group [Research Grants Totalling $523,000 Made to 40 Scientists This Year]
- CTRMN005141-5144 Cancer Research Opens Up New Areas, Extra Funds Appropriated for Study [TIRC Stepping Up Financial Support of Independent Health Research]
- CTRMN005145-5147 Scientists in 11 States Get Research Grants for Tobacco-Health Studies [17 Research Grants Totaling Nearly $200,00 Awarded to Scientists in 11 States for Studies of Tobacco Use and Health]
- CTRMN005148-5151 New Direction for Tobacco-Health Research in '61, Says Chairman of Tobacco Industry Research Committee [Future Research to Concentrate on How Lung Cancer and Heart Disease Originate]
- CTRMN005152-5160 Research on Smoking and Health Discussed by Scientific Advisory Board to T.I.R.C. [Health Research Expansion Called for in 22 Specific Areas]
- CTRMN005161-5162 Scientist Reports on Research Progress As T.I.R.C. Boosts Funds to $4,650,000 [Dr. Clarence Cook Little Proposed Steps for Medical Research]
- CTRMN005163-5163 Nation's Medical Students Offered Research Fellowships by Tobacco Research Group [Program Designed to Encourage Research As A Career]
- CTRMN005164-5168 Scientists in 14 States Get Research Grants for Tobacco-Health Studies [Fifteen Grants for New Research Announced]
- CTRMN005169-5173 Tobacco Industry Research Committee Adds $800,000 for New Research [Emphasis Put on Viruses, Bioassay, Psychological and Physiological Research]
- CTRMN005174-5176 ""Significant Developments" in Cancer Research Reviewed in Annual Report by Dr. C.C. Little" [Scientific Findings of the Past Year Reviewed]
- CTRMN005177-5179 Tobacco Research Group Offers Fellowships to Medical Students to Spur Interest in Research Work [Program Designed to Encourage Career in Research]
- CTRMN005180-5180 Tobacco Research Committee Chairman Comments on Mouse Skin Painting [Harmless Everyday Substances Can Cause Cancer in Laboratory Animals]
- CTRMN005181-5182 Smoking-Health Situation Calls for Facts, Not Emotions, Says Hartnett [Repetition Does Not Add to Scientific Knowledge]
- CTRMN005183-5217 Smoking-Health Situation Calls for Facts, Not Emotions, Says Hartnett [Repetition Does Not Add to Scientific Knowledge]
- CTRMN005218-5224 52 Additional Research Grants Made by Tobacco Industry Group [Money for Studies Designed to Give New Leads to Lung Cancer and Other Health Problems]
- CTRMN005225-5225 Medical Student Fellowships Offered by Tobacco Research Group [Program to Encourage Research]
- CTRMN005226-5228 Gaps Still Exist in Knowledge of Lung Cancer and Heart Disease, Says Little [Multiple Factors and Influences That Contribute to Lung Cancer Unknown]
- CTRMN005229-5230 Scientific Director of Tobacco Industry Research Committee Comment on Resolution by American Heart Association [TIRC Welcomes Recognition of Need for Further Research to Determine Full Facts About Smoking]
- CTRMN005231-5234 Tobacco Committee Adds $1 Million for Continuing Research Studies [Scientific Advisory Board Assured TIRC Will Provide More Funds]
- CTRMN005235-5235 [Scientific Director of TIRC Sent Telegrams to the Surgeon General and the President of the Ama]
- CTRMN005236-5236 [Ama Supports Research on Tobacco and Health]
- CTRMN005237-5239 [TIRC Renamed and Reorganized]
- CTRMN005240-5241 Dr. Howard B. Andervont Named to the Scientific Advisory Board [Editor of the Journal of the National Cancer Institute Appointed]
- CTRMN005242-5277 Tobacco Industry Group Awards $817,165 for Health Research [37 Additional Research Grants Have Been Awarded by the Ctr]
- CTRMN005278-5282 Scientific Director C.C. Little Reports Decade of Tobacco-Health Research [Findings on What Diseases Smoking Can Cause]
- CTRMN005283-5286 Council Awards $500,000 for Tobacco and Health Research [Number of Grants Awarded for Tobacco Use and Health Research]
- CTRMN005287-5291 Summary of the Testimony of Clarence C. Little Before the Senate Commerce Committee [Discussion on Cancer and How It Affects Our Bodies]
- CTRMN005292-5319 Council Awards $514,767 for Tobacco and Health Research [Number of Grants Awarded to Scientist Over the Period of 10 Years]
- CTRMN005320-5348 Tobacco - Health Studies Reviewed in Annual Report [Discussion on Cigarette Smoking Being Helpful with Causing Diseases in Smokers]
- CTRMN005349-5367 Tobacco and Health Research Awards Pass $9 Million Total [Grants Given to Scientist Studying Matter Related to Tobacco Use and Health]
- CTRMN005368-5375 Tobacco-Health Research Grants Awarded New York Scientists [Scientists Approved to Continue Research on Lung Cancer and Other Diseases]
- CTRMN005376-5382 Tobacco - Health Studies Reviewed in Annual Report [Studies of the Respiratory System in Experimental Animals and Human Patients Especially on Causes of Pulmonary Cancers]
- CTRMN005383-5384 [Opinions of Scientists That There Is No Relationship Between Smoking and Disease]
- CTRMN005385-5387 New Tobacco-Health Research Grants Total $2 Million [Number of Approved Grants for Studies on Tobacco Use and Health]
- CTRMN005388-5388 Furst Becomes Consultant to Tobacco Research Council [Dr. Furst Advise to Council on Programs Sponsored by Them]
- CTRMN005389-5393 Studies Raise Questions About Smoking As Health Hazard [Numerous Studies Done to Show What Effect Smoking Had on Our Health]
- CTRMN005394-5400 Broad Review of Tobacco-Health Picture Covered in Dr. Little's Latest Report Lung Cancer, Heart Disease, Chronic Pulmonary Ailments Are Complex in Nature, Says Noted Researcher Genetic and Environmental Factors May Be Involved Reports Scientific Director of Council for Tobacco Research [Recent Research Finding on Lung Cancer, Heart Disease and Chronic Pulmonary Ailments]
- CTRMN005401-5404 Significant Smoking-Health Finding Covered in Report by Dr. C.C. Little [Findings From Independent Scientists on Smoking and Health]
- CTRMN005405-5408 New Tobacco-Health Grants Announced; One Helps Revive Framinghan Heart Study [Awards Granted to Independent Scientists Researching Tobacco and Health]
- CTRMN005409-5412 New Scientific Findings About Cancer, Heart Disease, the Lung, Other Areas, Reported by Council for Tobacco Research [New Findings From Independent Scientists Relating to Tobacco and Health Issue]
- CTRMN005413-5415 New Smoking-Health Studies Boost Total to $23-Million [Council Awards More Grants to the Study of Lung Cancer, Viruses and Cancer, Heart Disease, and Chronic Pulmonary Ailments]
- CTRMN005416-5418 Progress in Tobacco-Health Research Achieved: Machines That Simulate Human Smoking [Machines to Help Scientists Effectively Study Smoke and Health Issues]
- CTRMN005419-5421 Noted Cancer Scientist Named Scientific Director of the Council for Tobacco Research [Dr. Hockett Who Was Acting Scientific Director Got Promoted to Research Director]
- CTRMN005422-5425 Massive Cancer Study Using Made-to-Order Mice [Study Using Mice to See If Human Lung Cancer Can Be Induced Regularly]
- CTRMN005426-5427 Tobacco Research Group Announces New Studies [12 New Studies Have Been Funded to Study Generic Factors in Lung Cancer and Emphysema and the Possible Influence of Nicotine on Fetal Growth]
- CTRMN005428-5429 Studies of Twins Expanded by Tobacco Research Group [Human Twins Used for Study to Determine Effects of Environment Agents on Various Diseases]
- CTRMN005430-5432 News About Smoking and Health Study Interaction of Genetic and External Influences in Lung Cancer [Studies Show That Only Minority of Smokers Get Lung Cancer Therefore Lung Cancer May Be Caused by Genetic Characteristics or External Influences Which People Have Been Exposed]
- CTRMN005433-5434 New Smoking and Health Grants Made by Tobacco Research Council [New Studies Have Received Grants to Continue Researching on Smoking and Health]
- CTRMN005435-5435 Yeaman Assumes Leadership of Council for Tobacco Research [Addison Yeaman Succeeds H.H. Ramm for Chairman and President of the Council for Tobacco Research]
- CTRMN005436-5438 14 New Studies Funded by Tobacco Research Council [Grants Awarded to Studies for Inhibition of Cancer by Different Chemicals, the Influence of Nicotine on Pregnancy and the Effects of Cigarette Smoke on the Body's Disease Fighting System]
- CTRMN005439-5441 Progress Being Made in Research on Emphysema [Scientist Discover Ways to Help Defend Against Emphysema]
- CTRMN005442-5444 14 New Smoking-Health Projects Are Approved [Recent Research Studies Dealing with Smoking and Health Have Been Given Grants]
- CTRMN005445-5446 Grants Awarded for New Smiking-Health Studies [Scientists Were Approved for Studying of Certain Enzymes in Human Lung Cancer and Emphysema]
- CTRMN005447-5448 Tobacco Research Report Discusses Heart Disease [Studies Have Found Progressive Atherosclerosis Rank First As Number One As Causes of Death From Cardiovascular Disease]
- CTRMN005449-5451 Grants Awarded for New Smoking-Health Research [New Studies Have Been Approved for Marker Substance That May Indicate Presence of Lung Cancer and on Smoking and Pregnancy]
- CTRMN005452-5453 Tobacco Research Group Funds New Smoking-Health Projects [A New Study for Relationship of Childhood Respiratory Disease to the Development of Adult Chronic Lung Disease]
- CTRMN005454-5455 Tobacco Research Group Reports... Funds for Smoking-Health Studies Pass $46,000,000 [Amount Council Has Given to Scientist for Research]
- CTRMN005456-5458 $5.9 Millions Given for Smoking-Healths Studies [Council Has Given Millions Over the Years to Researchers]
- CTRMN005459-5460 Tobacco Research Group Says... Continued Research Needed to Find Causes of Cancer and Other Major Diseases [Council Pledges to Continue to Give Financial Support to Scientists Studying Smoke-Health Issues]
- CTRMN005461-5462 $6 Million Granted for Smoking-Health Studies [Millions Given to Scientist for Further Study]
- CTRMN005463-5465 Tobacco Research Group Continues Funding for Independent Scientists [Council Has Provided Millions Over the Years to Researchers and Will Continue to Do So]
- CTRMN005466-5467 $5.5 Million Given for Smokin-Health Studies [Council Has Given Millions to New and on Going Studies Over the Years]
- CTRMN005468-5469 Annual Report Issued by Tobacco Research Group [Over 1.5882 Reports From Scientists Acknowledging Support From the Council Have Been Published]
- CTRMN005470-5473 $6 Million Awarded for 34 New Smoking-Health Studies [Millions Were Given to Scientists with New Studies and Continuing Ones From the Council]
- CTRMN005474-5474 Ctr's Latest Report Sets Abstract Record [More Reports Were Published From Scientists Acknowledgingg Support From Council for Tobacco Research Than Any Other Report Published in the Past]
- CTRMN005475-5475 Scientists Show... Growing Interest in Doing Smoking and Health Studies [Growing Number of Application Have Gone to the Council of Tobacco Research for Funding on Smoke Related Diseases]
- CTRMN005476-5479 $7 and A Half -Million Awarded for Smoking-Health Research [Millions Given to Scientists for Studying Lung Disease]
- CTRMN005480-5481 Council for Tobacco Research Announces... Hoyt and Hockett Retire After 30 Years: Gertenbach Is Named New President [Introduction to President of the Council for Tobacco Research]
- CTRMN005482-5482 Ctr's Annual Report Sets Abstract Record [the Number of Reports Acknowledging Support by the Council of Tobacco Research Is More Today Than It Was Years Ago]
- CTRMN005483-5485 Findings Published on Cigarette Smoke Inhalation Study with Mice [Results From Study Show That Smoke Did Not Produce Any Squamous Cell Lung Cancer]
- CTRMN005486-5525 Statement of Dr. Clarence Cook Little, Scientific Director, Tobacco Industry Research Committee, at Press Conference, University Club, New York City, June 15, 1954 [Regarding Relationship Between Lung Cancer and Tobacco]
- CTRMN005526-5533 "Transcript of Edward R. Murrow's First Tv Show on "Cigarettes and Lung Cancer"" [Regarding Experiments That Show That Cigarette Smoking Increases Chances for Lung Cancer]
- CTRMN005534-5541 "Transcript of Edward R. Murrow's Second Tv Show on "Cigarettes and Lung Cancer"" [Regarding Issue That Cigarette Smoke Does Not Cause Lung Cancer]
- CTRMN005542-5562 the Lung Cancer Problem and the Research Program of the Tobacco Industry Research Committee [Regarding Continuation of Study Dealing with Tobacco and Health]
- CTRMN005563-5573 A Report of Progress [Results From the Study of Smoking and Health Issue Will Greatly Depend on Well Planned and Well-Executed Scientific Research]
- CTRMN005574-5585 Tobacco and the Cardiovascular System the Program of the Tobacco Industry Research Committee [Program Strives to Discover Facts and Relationships Described with Objectivity]
- CTRMN005586-5597 A Search for Facts [Regarding Information Needed to Be Gathered on Smoking and Health Problems to Defend Industry]
- CTRMN005598-5605 the Lung Cancer Problem and the Research Program of the Tobacco Industry Research Committee [Discussion on Different Studies Will Continue to Be Made Until A Answer Is Found]
- CTRMN005606-5607 Cancer Research Guest Editorial Smoking and Lung Cancer Volume 16 [St Regarding Support Given to Scientist for Research]
- CTRMN005608A-5609 "Correspondence Regarding "Smoking and Health"" [Discussion on Researching on Tobacco and Health with Objectivity and Not Be Judgmental]
- CTRMN005608B-5609 Hypfibrinogenemia [Regarding Transfusions and Clotting Mechanism in A Case of Extraordinarily Delayed Post-Partum Hemorrhage]
- CTRMN005608C-5609 Diabetic Children [Admitting Omission of Different Data From Other Sources]
- CTRMN005608D-5609 Revocation of Licenses [Revoking of Registration From Dr. Louis A. Scinta]
- CTRMN005610A-5613 Mayo Clinic Head Believes Smoking Not Cancer Cause Tobacco and Health Volume 1 Number 1 [Smoking Not Believed to Be Cause of Lung Cancer, According to Some Noted Physicians]
- CTRMN005610B-5613 Six Experts State Doubts on Smoking-Cancer Theory Tell Congressmen Reasons for Position Tobacco and Health Volume 1 Number 1 [Reasons for Not Accepting Theory That Smoking Causes Lung Cancer]
- CTRMN005610C-5613 New Book Says Tobacco 'scare' Not Justified Tobacco and Health Volume 1 Number 1 [""Science Looks at Smoking"]
- CTRMN005610D-5613 Editors View Smoking-Cancer Tie As Unproved, Open Question Excerpts From Editorials Tobacco and Health Volume 1 Number 1 [Excessive Smoking Probably the Main Cause of Lung Cancer, While Moderate Smoking As Causation of Lung Cancer Has No Scientific Support]
- CTRMN005610E-5613 British Scientist Opposes Campaign Against Smoking Tobacco and Health Volume 1 Number 1 [Sir Ronald Fisher, British Statistician, Refuses to Produce Anti-Smoking Writing, States It As A Cause for Anxiety]
- CTRMN005610F-5613 'pick Your Expert, Take Your Choice' Tobacco and Health Volume 1 Number 1 [Witnesses Linking Cigarettes to Lung Cancer Testify Before House Operations Sub-Committee]
- CTRMN005610G-5613 'still Open Question' Tobacco and Health Volume 1 Number 1 [Authorities on Cancer State That Smoking Is Not Proven to Cause Lung Cancer]
- CTRMN005610H-5613 Smoking and Death Rates Tobacco and Health Volume 1 Number 1 [If Everyone Stopped Smoking There Would Be No Significant Change in Death Rate]
- CTRMN005614-5616 Summary of Comments for Delivery Before: Central Subsection, North Jersey Section, American Chemical Society, Elizabeth, New Jersey [Review of the Chemical Analysis of Cigarette Smoke and Investigations of Smoking and Lung Cancer]
- CTRMN005617-5620 the Public and Smoking Fear or Calm Deliberation? [How Doubt, Suspicion and Fear May Affect the Deliberation of Whether Cigarette Smoking Causes Lung Cancer or Other Ailments]
- CTRMN005621A-5624 TIRC Reports Progress in Smoking-Health Research Tobacco and Health Volume 1 Number 2 [Too Many Unknowns Exist Concerning Lung Cancer to Warrant Conclusions Citing Smoking As Causation of Lung Cancer]
- CTRMN005621B-5624 'tar' Misnomer for Condensed Smoke Tobacco and Health Volume 1 Number 2 [Difficulties in Analyzing Tobacco Smoke Make Tobacco Tar A Misnomer]
- CTRMN005621C-5624 New Statistics Contradict Anticigarette Theory Tobacco and Health Volume 1 Number 2 [Cigarette Smoking May Be Compatible with Normal Health Report on Done Smokers Who Have Longer That Average Life Span]
- CTRMN005621D-5624 TIRC Funds for Smoking Research Now Over $2,000,000 Tobacco and Health Volume 1 Number 2 [Scientific Advisory Board Approves 52 Grants and Renewals in 1957 Totalling $550,000]
- CTRMN005621E-5624 Press Questions Anti-Smoking Plan Tobacco and Health Volume 1 Number 2 [State-Supported Campaign Against Cigarettes Warranted in New York]
- CTRMN005621F-5624 Study Suggests Bronchitis May Be Prime Factor in Lung Cancer Tobacco and Health Volume 1 Number 2 [Preliminary Study at Beatty Institute Favors Bronchitis As A Factor of Lung Cancer]
- CTRMN005621G-5624 Doctors' Comments on Smoking-Health Tobacco and Health Volume 1 Number 2 [Increasing Number of New Chemicals in the Atmosphere at Fault for Rise in Cancer]
- CTRMN005621H-5624 Nation-Wide Lung Tissue Study Now Being Evaluated Tobacco and Health Volume 1 Number 2 [TIRC Studying Lung Tissues From 1,600 Persons]
- CTRMN005625-5648 Biological Aspects of Cancer Research Journal of the National Cancer Institute Vol. 30, No. 3 [St Background Research and New Information on Cancer Studies]
- CTRMN005649-5654 Interview the Cigaret Smoker and Lung Cancer Reprinted From Modern Medicine, Vol 26 [St Advises on Smoking and Its Relation to Health]
- CTRMN005655-5660 Comments on the Mortality of Smokers and Non-Smokers. A Paper by Harold W. Dorn Before the American Statistical Association Dec. 27, 1958 [Reflections on Figures Presented in Dorn's Paper]
- CTRMN005661-5671 An Experimentalist Looks at Statistics on Smoking [Reflections on the Figures in Dorn's Paper]
- CTRMN005672-5672 Letters to the Times Findings on Smoking [Statistical Proof of Link Between Smoking and Cancer Denied]
- CTRMN005673-5683 A Brief Review of the Smoking-Lung Cancer Theory [Review of Data Known on the Relation Between Cigarette Smoking and Lung Cancer]
- CTRMN005684-5686 Cancer-the Research Approach [Discussion on Cancer and A Category of Factors Which May Play Roles in Cause and Development of Cancer]
- CTRMN005687-5692 [Address Before the Burley and Dark Leaf Tobacco Export Association, Inc. Information About the Research Program Supported by the TIRC]
- CTRMN005693-5697 Some Phases of the Problem of Smoking and Lung Cancer the New England Journal of Medicine Vol. 264 No. 24 [St Disputes Findings That Smoking Causes Lung Cancer]
- CTRMN005698-5704 Some Aspects of the Lung Cancer Problem Reprinted From Punjab Medical Journal Vol. Xi No. 7 [St Discussion of Relationship of Cigarette Smoking to Lung Cancer]
- CTRMN005705-5735 Current Knowledge of Tobacco and Health [Discussion of Experimental Attack on Lung Cancer and Tobacco Use]
- CTRMN005736-5739 Cigarettes-Why More Research? Reprinted From the Yale Scientific Magazine [St Comments on the Uncertainties of the Correlations Between Cigarette Smoking and Lung Cancer]
- CTRMN005740-5740 Why Do People Think That Quitting Smoking Affects Their Appetite or Their Weight? the Apothecary [St Comments on the Scientific Basis of How Smoking Affects Hunger]
- CTRMN005741-5754 Address to Be Delivered by Dr. Clarence Cook Little, Scientific Director, the Council for Tobacco Research - U.S.A. At A Dinner Honoring the Centennial of the University of Kentucky and the Burley Tobacco Industry Lexington, Kentucky January 12, 1965 [Talk Addressing Research Programs of the University of Kentucky]
- CTRMN005755-5772 Communications and the Biological Sciences [Brief Discussion of Principles That Should Inspire and Guide Communications in the Biological Sciences]
- CTRMN005773-5785 Perspectives in the Experimental Approach to the Human Lung Cancer Problem [Experimental Research on Lung Tumors in Animals May Lead to Insights on Human Lung Cancer]
- CTRMN005786-5798 Tobacco and Health Research [Elaboration on the Purpose, Research Practices and Studies of the TIRC]
- CTRMN005799-5805 Tobacco and Health Research [Discussion of Experimental Studies by the TIRC Concerning Smoking and Health]
- CTRMN005806-5813 the Research Perspective on Smoking and Health [Discussion on the Search for Causes of Diseases with Which Smoking Has Been Associated]
- CTRMN005814-5820 Tobacco and Health Research [Discussion of Studies on Cigarettes and the Diseases Statistically Associated with Smoking]
- CTRMN005821-5834 Tobacco and Health Research - Where Shall We Go From Here? [Suggestions for Continuing Studies and Research on Cigarette Smoking and Health]
- CTRMN005835-5852 A Look Ahead Smoking and Health - Where Do We Stand? [Talk on Chronic Diseases and Factors of Their Causation and Development in Relation to Cigarette Smoking]
- CTRMN005853-5854 Smoking-Disease Links Continue to Lack Scientific Proof [Discusses the Role of the Council for Tobacco Research]
- CTRMN005854-5854 Lawrence Promoted to Vp Post at Mmi [Jack Riddle Announces the New Vp of Micro-Magnetic Industries]
- CTRMN005854A-5854 Philip Morris Expands Promotional Allowances [Discusses Special Offers Made to Philip Morris Vendors]
- CTRMN005855-5882 Chapter 3 the Tobacco Health Issue: An Overview of Medical Research [St Questions Methodology of Experiments Where the Sole Objective Was the Attempt to Induce Tumors]
- CTRMN005883-5900 the Research Program (Cancer Segment) of the Council for Tobacco Research - U.S.A., Inc. Presentation Before the Tobacco Working Group [Describes the Concept, Plan, and Purpose of the Council for Tobacco Research]
- CTRMN005901-5902 Smoking Prevention Education Act Hearings Before the Subcommittee on Health and the Environment of the Committee on Energy and Commerce House of Representatives Ninety-Eighth Congress First Session on H.R. 1824 [Statement of Sheldon C. Sommers]
- CTRMN005903-5919 [Regarding Anti-Smoking Bill]
- CTRMN005920-5931 Hearings Before the Subcommittee on Health and the Environment of the Committee on Energy and Commerce House of Representatives Ninety-Eighth Congress First Session on H.R. 1824 March 9 and 17, 1983 Serial No. 98-8 Statement of Robert Casad Hockett Regarding H.R. 1824 [Disputes Findings Set Forth in H.R. 1824 Regarding Cancer, Cardiovascular Disease, Atherosclerosis and Emphysema]
- CTRMN005932-5932 Hearings Before the Committee on Labor and Human Resources United States Senate Ninety-Eighth Congress First Session on S. 772 May 5 and 12, 1983 [Concerning Smoking Prevention Health and Education Act of 1983]
- CTRMN005933-5940 Statement of Sheldon C. Sommers, M.D., Consultant in Pathology, Lenox Hill Hospital, New York, N.Y. [Comments on Smoking Prevention Health and Education Act]
- CTRMN005941-5963 Hearings Before the Committee on Labor and Human Resources United States Senate Ninety-Eighth Congress First Session on S. 772 to Promote Public Health by Improving Public Awareness of the Health Consequences of Smoking and to Increase the Effectiveness of Federal Health Officials in Investigating and Communicating to the Public Necessary Health Information, and for Other Purposes Statement of Robert Casad Hockett Regarding S. 772 [Disputes Methodology of Experiments Which Expose Animals to Smoke]
- CTRMN005964-6009 Hearings Before the Subcommittee on Health and the Environment of the Committee on Energy and Commerce House of Representatives Ninety-Seventh Congress Second Session on H.R. 5653 and H.R. 4957 March 5, 11, and 12, 1982 Serial No. 97-106 [Disputes Methodology of Experiments to Demonstrate That Cigarette Smoking Can Cause Lung Cancer in Animals]
- CTRMN006010-6012 Testimony of Dr. Robert C. Hockett During Hearing on Cigarette Smoking and Health Before the Subcommittee on Oversight and Investigations of the House Committee on Interstate and Foreign Commerce, October 5, 1978 [Responds to Question Regarding Research on Health and Smoking]
- CTRMN006013-6023 Statement of Robert C. Hockett, Ph.D. Before the Subcommittee on Oversight and Investigation of the Committee on Interstate and Foreign Commerce in Response to the Letter Dated September 27, 1978 From the Chairman of the Subcommittee to William U. Gardner, Ph.D., Scientific Director, the Council for Tobacco Research - U.S.A., Inc [Discusses the Purpose of the Council for Tobacco Research]
- CTRMN006024-6069 Hearings Before the Subcommittee on Health of the Committee on Labor and Public Welfare United States Senate Ninety-Fourth Congress Second Session on S. 2902 February 19, March 24, and May 27, 1976 [Disputes Scientific Basis of S. 2902]
- CTRMN006070-6125 Hearings Before the Consumer Subcommittee of the Committee on Commerce United State Senate Ninety-Second Congress Second Session on S. 1454 Serial No. 92-82 [Discussion of Cigarette-Smoking and Peptic Ulcers]
- CTRMN006126-6135 Report of the Scientific Director [St]
- CTRMN006136-6189 Hearings Before the Consumer Subcommittee of the Committee on Commerce United States Senate Ninety-Second Congress Second Session on S. 1454 February 1, 5, and 10, 1972 [Discusses Edimeological Comparisons Between Smokers and Non-Smokers]
- CTRMN006190-6200 [Bibliography Listing Over 1,275 Articles and Books About Tobacco and Disease]
- CTRMN006201-6311 [Articles About Tobacco and Disease]
- CTRMN006312-6321 Hearings Before the Consumer Subcommittee of the Committee on Commerce United States Senate Ninety-Second Congress Second Session on S. 1454 to Amend the Federal Cigarette Labeling and Advertising Act to Require the Federal Trade Commission to Establish Acceptable Levels of Tar and Nicotine Content of Cigarettes [Statement of Dr. Sheldon C. Sommers]
- CTRMN006322-6348 Hearings Before the Consumer Subcommittee of the Committee on Commerce United States Senate Ninety-Second Congress Second Session on S. 1454 to Amend the Federal Cigarette Labeling and Advertising Act to Require the Federal Trade Commission to Establish Acceptable Levels of Tar and Nicotine Content of Cigarettes [Statement of Dr. Robert Casad Hockett]
- CTRMN006349-6359 Hearings Before the Consumer Committee of the Committee on Commerce United States Senate Ninety-Second Congress Second Session on S. 1454 to Amend the Federal Cigarette Labeling and Advertising Act to Require the Federal Trade Commission to Establish Acceptable Levels of Tar and Nicotine Content of Cigarettes [Statements of Dr. Sheldon C. Sommers and Dr. Robert C. Hockett]
- CTRMN006360-6370 Hearings Before the Consumer Subcommittee of the Committee on Commerce United States Senate Ninety-Second Congress Second Session on S. 1454 to Amend the Federal Cigarette Labeling and Advertising Act to Require the Federal Trade Commission to Establish Acceptable Levels of Tar and Nicotine Content of Cigarettes [References Reporting on Tobacco and Nicotine]
- CTRMN006371-6412 Hearings Before the Committee on Interstate and Foreign Commerce House of Representatives Ninety-First Congress First Session on H.R. 643 A Bill to Amend the Federal Cigarette Labeling and Advertising Act with Respect to the Labeling of Packages of Cigarettes and for Other Purposes (and Similar Bills) [Statement of Dr. Sheldon C. Sommers]
- CTRMN006413-6492 Hearings Before the Committee on Commerce United States Senate Eighty-Ninth Congress First Session on S. 559 and S. 547 Bills to Regulate Labeling of Cigarettes and for Other Purposes [Statement of Dr. Clarence C. Little]
- CTRMN006493-6533 Hearings Before the Committee on Interstate and Foreign Commerce House of Representatives Eighty-Ninth Congress First Session on H.R. 2248 A Bill to Amend the Federal Food, Drug, and Cosmetic Act So to Make That Act Applicable to Smoking Products [Statement of the Council for Tobacco Research U.S.A. History and Organization]
- CTRMN006534-6540 Hearings Before the Committee on Interstate and Foreign Commerce House of Representatives Eighty-Ninth Congress First Session on H.R. 2248 A Bill to Amend the Federal Food, Drug and Cosmetic Act So As to Make That Act Applicable to Smoking Products [Statement of Clarence Cook Little, SC.D.]
- CTRMN006541-6548 Hearings Before the Committee on Interstate and Foreign Commerce House of Representatives Eighty-Ninth Congress First Session on H.R. 2248 A Bill to Amend the Federal Food, Drug, and Cosmetic Act So As to Make That Act Applicable to Smoking Products [Statement of Robert Casad Hockett, Ph.D.]
- CTRMN006549-6577 False and Misleading Advertising (Filter-Tip Cigarettes) Hearings Before A Subcommittee of the Committee on Government Operations House of Representatives Eighty-Fifth Congress First Session [Statement of Dr. Clarence Cook Little]
- CTRMN006578-6611 False and Misleading Advertising (Filter-Tip Cigarettes) Hearings Before A Subcommittee of the Committee on Government Operations House of Representatives Eighty-Fifth Congress First Session [Statement Concerning the Origin and Purpose of the Tobacco Industry Research Committee and Its Proposed Functions]
- CTRMN006612-6614 False and Misleading Advertising (Filter-Tip Cigarettes) Hearings Before A Subcommittee of the Committee on Government Operations House of Representatives Eighty-Fifth Congress First Session [Hartnett Cites Scientists Doubting Smoking-Cancer Theory]
- CTRMN006615-6618 Research Into Smoking and Health [Arguments Against Tobacco Cancer Link]
- CTRMN006619-6623 [Study to Examine Reported Causes of Death in Each of 17 Regions in Houston Specifically the Five Major Respiratory Diseases]
- CTRMN006624-6624 A Frank Statement to Cigarette Smokers [Industry Promotes Research Into Tobacco Disease Link]
- CTRMN006625-6625 the Council for Tobacco Research - U.S.A., Inc. Board of Directors [Members of the Board]
- CTRMN006626-6627 the Council for Tobacco Research - U.S.A., Inc. Scientific Advisory Board [Members of the Board]
- CTRMN006628-6634 No. E-121,486 I. D. Rogers, Individually and As Independent Executor of the Estate of Marjorie Helen Rogers, Deceased; Et Al Vs. R. J. Reynolds Tobacco Company, Et Al in the District Court of Jefferson County, Texas 172nd Judicial District Third Amended Notice of Intention to Take Oral Deposition [Matters on Which Ctr Witnesses Must Be Knowledgeable]
- CTRMN006635-6967 Deposition of Dr. James Glenn [Deposition of Glenn in the Matter of Broin]
- Author
- Hobbs, W.D., Ctr
- Request
- 118
- Type
- ANNUAL REPORT
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- 002
- UCSF Legacy ID
- onq30a00
Document Images
L:X'1'1(A COPY REPORT
Of
THE COUNCIL FOR
TOBACCO RESEARCH-U.S.A., Inc.
1982
1,
Organization and Policy
The Council for Tobacco Rasearch-U.S.A., Inc. is tbe sponsoring aycucy
of a proFaJn of research into questions of tobacco we and hcalth. It is tbe out-
growth of ao ortanir..tioo formed early in 1954 by tobacco manufacturcn,
jrowera and warehowemen. Research support has been mainly through a pru-
yram of lraota-io-aid supplemented by contracu for rescarch with irutitutionm
and laborawrie.. TLe Council does oot operate any researcb facility.
The ScicntiCc Advisory Board to The Council meets regularly to cvaluaie
applicationa for research aupport, judging tbcro solely on the basis of acicotillc
mcrit aod rdevanos.
The Council awards research grants to independent scientists who are as-
sured complete scieatiflc frocdom in conducting their atudies. Grantces alone
are reapoou" tor reportinj or publishint their flodinp in the acccptcd scicn-
tibc raaoacr - throuslt modiul aqd acicntitk jouroal. and socictica.
WlLLIAM D. Noaas
Chairman
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198'l RRI'OR'1' p ~
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o d i
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TiIE COUNCIL FOR TOBACCO RESEARCH-U.S.A., Inc.
TIIE COUNCIL FOR TOItAC/'O IIESF.AIit'fl-U.S..4., Inc.
110 Eut 59th Street, New York, N.Y. 10022
c
Slal:NTtI'll: ADVISUItY 1tl)AIiI)
to Thc Council for Tobacco Rcacarch-U.S.A., Inc.
as of December 31, 1992
LEON O. JACOBSON, M.D., Chuirutun
lusrph Regcwlcirt Pru/c'ssur uJ lliulugic-ul Scirrn rs ( rinrritus )
I'ruJcssur of rlti Departmcnt u/ Mrdiccinc (rrncritus)
University of Chicago
Chicago, Illinois
RICf IARD J. BING, M.D.
Dirrctur u/ fs'.rprrirnrnrul Cardiology ruuf St itnti/ic /).vrloqnc'nl
Huntington McJical Research Institutc, PasaJcna, California
PruJrssur u/ Medicine (rrneriuo')
University of Southern California School of Medicine
Los Angcles, California
ROSWELL K. BOUTWELL, 1'tt.D.
Pru/rasor u/ Onculugy
McArdlc Laboratory for Cancer Research
Univcrsity of Wisconsin
Madison, Wisconsin
DRUMMOND 11. LIOWDLN, M.D.
l'rolrssur and Ilrad
DcPartmcnt of Pathology
Unrversity of Manitoba I Ieahh Sciences Center
Winnipeg, Canada
MICHAEL J. BRENNAN, M.D.
PresiJent and Mulical Director
Michigan Cancer Foundation
Dctroit, Michigan
JOSEPH D. FELDMAN, M.D.
Mernber, Research lnstitute of Scripps Clinic
Scripps Clinic and Research Foundation
La JoUa, California
WILLIAM U. GARDNER, Ptt.D.
E. K. !lunt Pru/essar u/ .1 natuury ( cnrrritus )
Yale University School of Medicine
New tlaven, Connecticut
PL'rLR M. I LOWLEY, M.D.
l.aboratury uf I'athalogy
National Canccr lnstitutc
Bethesda, Maryland
11ENRY 1'. I.YNCf f, M.D.
l'ru/cssur and Chairman
L)cpartment of Preventive Medicine and Public Health
Crcightun Univcrsity School of Medicine
Umaha, Nebraska
G. BARRY I'IERCE, M.D.
Aiurrirurt Cunrrr Scx4rty Crurrnniul Rr3rurc h NruJrssur
llnivcr.ity of Colorado l{eallh Sclcncc\ Cenlcr
1)cnvcr, CuluraJu
GORDON lf. SATO. Ptr.D.
f'rujr.r.wr u/ hiulugy
University of California, San Diego
La Jolla, C'afifurnia
SIILI.tX)N C. SUMMIiRS
Sricutifir Uirrrlur, Thc C'uuncil fur Tobacco Rcscarch-U.S.A., Inc.
('Gni4 ul l'ru/rs,fur u/ l'ur/wlugy
Collcgc of Physicians & Surgcuns of Colurnbia Univcrsity
New York, New York
ScieutiGc StrfC of '1'lrc Council
SHELDON C. SOMMERS, M.D.
Scic'rui/ic Director
ROBERT C. HCKKETT, Pu.D.
Research Dirrrtur
DONALD II. FORD, Ptt.D. VINCENT F. LISANTI, l).M.D.
if ssuuutr Kcsrarrh Director Associutc Kcscun b Dirrc rur
DAVID STONE, 1'tt.D.
Associutr Krarun'/r Dircc lur
t.
CONTENTS
Introduction . ... . . . . 5
Abstracts of Rcports . . . . 7
Canccr-Rclatcd Studics . . - 7
The Rcspiratory System . . . . 23
Heart and Cireulation . . . . 49
Ncuropharmacology and Physiology . . . . . - . . . 60
Pharmacology and Biochemistry . . . . . . . 65
Immunology and Adaptivc Mcchanisms . . . 78
Epidcmiology . . . . . . . . . . . . . . . . 89
Activc I'rojccts . . . . . . 95
Cornplctcd Projccts . . . . . . . . . . 105
Index of Principal Investigators . . . . . . . . . . . IlK
Indcx of Scuiur Authors . . . ... . . . . . . 119
Introduction
®
~
H
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'I he ('uuncil tor Tobacco Kescarch's program cxprndcd turthcr tTP1982
in rc.ponx tu a gruwing number of solid and ullcn yultc imgin.ruvc grant
apphc:Itiun. 111.11 cuntinucd to comc Iruns indepcndent xnnusks. It xcnted
clCar Junog the ycar Ihal evcn with the vasl amount ul rc-scarch done tur ncarty
thfcc dccadr. nt/o yucslwns rclatcd to smoking .nd hc.rlth, many in the sci-
cntr6c cumnnmuy Inhcvc impurlam gaps in knowlcddc r.mam to be lilkd.
'Ilxrctuic, rcll.cung whal appcars 1o be an in.rc.xd tnlcresl in smoking
.md hcahh f.x:uch rmung scwnlhls, the Council suhslanually enlrrgcd its an-
nu.t1 cumnuUninl. Ilic acltun :J.o rclkctrd the Councd's suptxrrl lor the pl.ns
rnd Jc+ir.N ut ih SaanUtic Adviwty Board, which /s alw:ryN on the luokout
lur yuwhh.d mvc.lig.tlurs :u vtutly pectliC jrYas Ih.A are corlvidered irnpurunl.
S-u.r 1'fl 1. the ( uuncJ ha% piuvr.lcd 17b.1MM11MM! La iLs Ics.jrch prugram,
wlu.h I. IKIwvcJ lu Iw the I.ug..1 .md mua ritlcn.rvc ul its ktnd in the wurld.
Ifrlay, a..u Ih: oW.a. Ihr piul;r.urr cmph.f.ucv rrscjfih by independenl sei-
culnl. In Ihnl; C.ItJN/v.1~/1IJr Ih.ct.c. arxl chrunic pulnwnary atbucrlK.
I bc.r luu.l, wce. lur M_'9 urnginal granh aoJ nurncruus renewals, smce
iuany ol the piul:cl. w.fe Iur 1w.f rnd Ihtre yc:us ..r lun6rr. the ('uuncd h.r-,
Ihiuugh the y:..n, Iun.l.d 466 i..e.u:has in 272 nkJt.:rl schouls, husprlah
jnd tr.c.urh m.utuuun..
A nu.r+uic ot Ihc ('ouiw'ds vuulnhuUUn Io the jdvan:cmerH uf s.iculilic
Inlunn.iUon u.ten m the nun1hcr ul rcpurl% puhh.hed by gnntccs Ihal .c-
kouwlcdgc ('uuikil supporl. Ihal ligurc was'_,168 w of 1?rccutbcr 11, I9M_'.
the CouncJ r.m:nns Jcflicalcd to cuntinurncc of h% resc.rch ctlort.
Abstracts of Reports
Fulkrwing art ahatracts, approved by the authoo, of rcprxts rnr ncw rescarch
ackrrowk;dging sulr{xxt from The Council that have appcucJ in xicnti(ic j.wrnals
sincc publication of thc 19g1 Rcport. The name of the grant rccrprcnt is in rtalics.
Thc abstracts arc grouped under these headings:t. Canccr-Rclatcd StuJics,11.
llrc Rcspiratory Systcm, 111. Heut and Circulation. IV. Ncunrpharmaculugy and
Physiulogy. V. Pharmacology and Bwrchcmiury, VI. ImmurKrkrgy and Adaptive
Mechanisms, VII. Epidemiology.
I. Cancer-Related Studies
MECI(ANISM OF ACCION OF fiLNZO/aIPYR(sNf. AND NICOTINE ON
HORMONE PKODUC"CION BY RAT PITUITARY TUMOR CELLS
Akhough hrxTnoncs have bccn associated with induction and pwEres+run of tu-
nrxs in many cxpcnmcnul systcros. the role of hurrnones in the process uf initiation
and prugrcssiun uf carcinugcncsis is rNx clcarly dchned as yet. In thc present attcmpt to
wxkrstand tlr- rncchamsm of action of bcnm(a)pyrcnc (fiaP), a cyclic anunauc
hydakarbrm. anJ that of nrcwrnc, the tobacco alkaloid, the clfectu of thesc agents on
Ixulactin (1'KI.) arrJ gruwth IKxnrrxrc (Gil) synthcsu by rat pquuary IuuNx cells in
culture (GI I cclL ) were audicd. Treatment of Gil cclls with mcrxmc (U.1-XK) µl:/ml)
ncuhcr affcctcJ the growth nr)r significantly altcred the gcnrral pattern uf humrunc
pu><lucurxt in these cells. BaP at concentrations greater than Sµgnnl xrevcrsrbly
inlxhitcd the gruwth uf these cclls. The sublethal cunccntrahuns of HaP. which did not
al(cct either (I) cell growth, or (2) amino acid transfxwrt rx (3) aaal protein synthcsrs or
Jcgradatirxt, did however inhibit spccihcally hurmunc synthc.is by these cells. More
interestingly, axrcentrauons of nicotrrre, which did na affect either cell growth or
Ixxnwnc syntlresrs, modulated both of thcse cellular prucc»es in thc prcscnce of HaP.
A cunccntratHm dcpcndent sonwlauon uf micrownsal iSaP uwnaraygcnax activity
was uhscrved in nicotine or BaP ucatcd cells. The cllccts of ::xsc subsunccs on
stimulation uf IIaP mrxwuxygcnase activity scems to be additivc. Nicotine alvr cn-
hanccd the asxkiauun uf raJioa.uvity (presumably /'H It3aP nkt,tb.ddcowith DNA m
)'H/UaP trcatcJ cells. 1t is concludcd that niatxrnc by uself did skw Jcnwmstratc any
cyt.wuxic cfl'cct nur inlluence hurrrwne synthesu in GH cclls. IJuwevcr. nlarNlnc
atimulatcJ Bal' munrwaygcnax activity anJ the rrueracuun ul 1'H1BaP nktububtcs
wrth ccllular UNA anJ alsu modulatcJ BaP irnlurcJ intubitrun u( MxrrwMk synth.su m
Gil cells.
CTakrabani, S., Hai>LS- S. D. and Bra»wi, l1. K.
!!rw'hemrul und 8rupbisirul Rrararrh C'r,m.aunrruuuru IOK(.) S'M-(03, IV%:.
Frum t)rc I-abxatury of Ph:unr.rculugy, H:warJ SrM.d of D.nt,rl Medicine anJ Dc -
partnknt uf 1'harrnaculugy, FluvarJ MrJrcal SaNrul. Busam.
7
POSITIVE C'ORRELATION BGTWEEN HIGII ARYL IIYI)R<KAR(iON
HYDROXYLASE ACTIVITY AND PRIMARY LUNG CANCER AS
ANALY'LF3) IN CRYOPRGSERVED LYMPHOCYTES
Blood sampks from SI paticnts at the Veterans Aduunisoratiun 1lu.pital, I luur
lon, were collected, cakd, and scm tu Microbiological Asx>tiatcs, Bcthcxla, MD.
where the lymphocytes werc isolated and cryoprcxrvcd :n - I'JA°C bclure cxuoina-
tion. AI the timc of assay, lymphocyte samples were simultaneously thawed, phytolrc-
ongglutinin activated, and analyzed (or benz(a)anthracenc-induccd aryl hydrucarbun
hydroxylase (AHH) kvels, ('H/thymidinc incor(wration, and reduced mcuunanridc
adenirse dinuckotide-dependent cytuchrome b, (cytuchrume c) rcductasc activity. Uc-
lennirrations werc made at both 96 and 12U hr in culture, and pcak activittcs wcrc
compared among the SI individuals who cxprc»ed such lesions as syuatnous ccll
carcirwmas (22`b), adcnocarcinomas (14%), oat ccll carcinomas (64u), chronic ub-
srnactivc pulmonary disease (22'b), and other nonmalignant dueascs. O) the 14 high-
est AHH/cytuchromc c activities obscrvcd, all were found in paticnu with pruuary
lung cancer. Mean AHH/cytochrome c activities were U. M9 fur lung cancer patients (a
Iot:J of 21) and 0.47 for noncancer patients (a lotal of 30). No relationship was
obscrvcd belwcen AHH/cytochtomc c activity and age of paticnt, number of cibarcttes
srrsuked, family history of cancer, location or histological type of twnur, or Icvcl of
phytohernagglutinin blastogcnesis (I'HlthymWine cpm/cytuchrunk c). Although the
present communication presents data which show a striking correlation between the
prcscnce of pulnwrsary carcinomas and high AHII levels in lytnphucytcs tsulatcd (rum
patienu, whether the higher AHH kvcls arc the cause or the result of the primary lung
cancer still remains to be determined.
Kouri. R.E. rr al. (Micrubiologicrrl Associurrs)
Concrr Rrsrwcb 42(12):5030-5037, 1982.
O[Aei support: American Cancer Society and the Vctcratu Adnunisltatiun Hu.pttal,
1 iuusuia.
From the Dtvisiun of Toxieulogy and Orrculugy, Mtcrubiulugical Asx,ciatcs, Ile-
thesda, MD, Departmeru of Biological Sciences, Nonh Tcxas State Univcnity, Den-
tun. and the Department of Motlicine, Baylor College of Medtcine, and Veterans
Hospiul, Houston.
ARYL HYDROCARBON INDUCIBILITY IS NOT ALTERED IN BLADDER
CANCER PATIENCS OR THEIR PROGENY
The ruk of aryl hydrocarbon hydruxylasc (AHH) urJucrbthty in prcdi.pt.inK
perwrrs to cancet has been the subject of considerabk cuntruvcny, with suntc reptms
shuwing an increased risk of respiratury cancer in perwns with high AHI I irrducibtltty
and others showing no such effect. In the present sttrdy, the pu»ible m0ucrke of AHl I
on susceptibility to bladder cancer in humans was carefully investtgatcd. AHH nniuct-
bility was mcasured in the cultured lymphcuytes of 16 patients who were tktng lul-
luwed a(ter successful treatment for blackkr cancer, in 53 progeny of bladder cancer
p.t,cnl., atxl in nutdkd cuntrul.. In both thc progcny and paucnt pupulawm., nu
evidence was Irwtkl for a diffcrerxe between the dutnbuuun of AHiI tnduitMltty or
induced AHiI activtty ctnnpared to the diuribuhon atnong corurul tndtvtduah. Thus.
AHI I aruvity or inducibilhy dtd rwl appear to bc a rnajor dctcrmnant of bladder cancer
risk in humans.
1'aigcn, B. rr u(. (Puigrn. A. J
lnrrrnuriunul Juurnuf ojCuncrr 23:312-315, 1979.
A
Urbrr support: National Cancer Institute
Frum the Dcpartmcnt of Molecular Biology. Ruswell Park Mcnwnal Institulc. ~
Bulfaks.
MONOOXYGENASE AND EPOXIDE HYDROLASE REGULATION IN
PRIMARY FtiTAL RAT LIVER CELL CULTURE
In this rcpun, various lines of evidence arc presented dcrn,mstratmg Ihat a cyto-
chrunx: P450 comparahlc to that of the adult rat liver can be found in /etal hcpauicyte
culturc. and that nm appeuancc is strictly controlled by nuticords. The liM.vidcncc
cited hcre slwws that the level o( the cyn>Lhromc P450 content in primary Ictal liver cell
culturc is rcourkably atablc and does n.N sigmAcantly dtllcr Irutu that hwnJ in Ict.rl
hvcr uscd fut.ulturc prcparattun. Aryl hydnrcarb.m hydruxyl.r.c IA1111) arMl epustdc
hydrulasc (El l) Ji uvuUC. arc casrly nx~surabk 10 thc.clls and Icnd tu Jc.rcax sltghtly
as a IuwK'ttun of tlK culture duration. High conccntrauutr of phcntbarbual (Ptl l urduces
both AI111 and 1i11 acttvitics, whereas hcnt (a)unhraccne t1fAI xts prclcrenn.lly and
2.3,7,1itctrachlunxldx ntu-p-dwxin selectively on A)1H acttvtty. Tnns-stiltwne ux-
kk atwl ethoxyywn behave as selective induccrs of EH. Other evtdcn.e shuws that
AIIFI and EII activities in fetal liver cells uc mudthed in a parallel manner by the
aWniun uf dcxanwthasunc to the culture medium. This eflect is biphasic as tl>< eruyme
acttvtttcs arc lirst inhibited and then induced when the contcotd axnentrauun is
prugrcsswcly raised. The cunirutd also rrxxlities the AHII activity .xt a yualitaNve
ba.is. In the absence uf the conicuid, the enzyme activity is inhibited rn ruru by u
napluMrllavonc but nnt by mctyrapnnc. Dexameth:.xme alsu nKKlthes thc induction of
AH) I by PB and BA. both on a qualitative and yuarrutative basu. Ovtrall, un the basts
ul' Ihis and other evirknce, it xctns yuuc reaxmabk to assumc that prtnary fetal r:u
liver cells tn.ulture might cunstitutc un interesting uwxkl lur studying the physruNppr
cal regulatory rncchanunu of drug nxtabulizing enzymes.
Girlta. J. t.'% rr ul.
In: Snyder rr u( (cd.. ): Htulugrrul Rrurrivr lnrnmrdturrs ll. Purr A, N. w Yurk:
1'knunt Publuhtng Corp.. 1982. pp. g7-97.
Other support: Frnx(s National dc la Rcchcrche Screntrliyue.
Protn the Lal>,or.uuuc rk Clwntc Mrdtcalc et Jc Tuxtca,lugte, Inuitut .k P.nMdogn,
Uutvtt.dc dk Lt.ge. l.t.tigc. kla'll;tuut.
It)
1
t
MULTIPLICITY OF CYTOCHROME P-450 IN PRIMARY FLTAL
HEPATOCY7FS IN CULTURE
TM pcrirutal period of life is a critical tiasc for thc quanntauvc and qualitauvc
dcvebprncnt of micsusurnal morKwaygcrusscs. and earber ubscrvatiuns suggcst th.d
fetal hcpatocytcs in culture might constitute an idcal tuul lur studying the pcnn.tal
regufatary mechanism of mooooxygenascs. While it has becn known for a while that
pnmary fcul rat hcpatocytcs in culture display diffcrent nwrKxrsygcnasc activiuo
which can be induced by several chemical inducers, thcse hcpatucytcs wcrc bclievcd
uotil now to produce only one singk cytochrorne P-450 spccies, nanicly the cytu-
chrorrre P,rIS0(orP-448). Howevu, it now scems possibic to induce other cynxhrume
P-450 spccia in thesc hepatocytes, providing that they receive an appropriate hormu-
nal trutmcru. ln the worlt rcportod bers, cxamination was made of the effect of
duameQtasooc on various morrooaygenases and on the type of cytochromc P-450
wppatting these enzymic activities. Thrce enzymcs, aryl hydnx:arbun hydruxylasc,
ettwaycoumaria doetbylasc and aldnn monooaygcnase, wcre measured for this pur-
pose. Results of this study show that the prcsence of dcaamcthasunc in the culturc
medium pttoducts qualilative and quantitative changcs in the ownuusygenase-supI^xt-
wg cytochrorsre(s) Pr150. For low deaameUusone concentrations, a cytochrumc P-450
is formed displaying biochemical and biophysical propenics simdar to thosc induccd
by phenobarbrtat in the adult rat liver. At higher concentratiuns, similar qualitative
changes arc observed; but a quantituive phenomenon occurs, the (cynuhrome P-450)-
dcpcodeat uszymic activities bciag also induced. Dcxanscthasone also has a syncrgis-
tic effoct in the induction of cnzymic activity by the mixturc of p(scnobarbital plus
bcrwnthraccae. Tbe various biochemical changes induced by dexamcthawnc in the
fetal ccll cultures parallel those observed in vivu during the pennatal period of life.
Thcrefore, this ccll culture system may constitute an intcresting model fur studying the
onwgcnic development of liver rrwrsooxygcnascs.
Krcrsxrs, P.. Goujoa, F., Dc Gracvc, J., Van Cantfon, J. and Gir)rn. J. E.
Eruopcan Jo+unal ufBioclremisrry 116:67-72, 1981.
OiA.r sswrwt: Foods rk Is Rahen:lte Scicntifiquc Mtrlicalc.
From the L..bontoirc ck Chimie Mtdica)e, lnstitut de Pat(wlugie. Untvcrsnt dc Lttgc.
LJtgc, Belgium.
DNA METIiYLAT1ON IN NORMAL AND SV40-TRANSFORML-D IIUMAN
FIBROBLASTS
The 5-methykytosine base contcnt of DNA in four numal and (rwr SV4U-(rrnS
furmed human diploid fibroblast cullurts was measured by high pcrturnrancc liquid
chromatography (HPLC). Rcsults show that the percent uf cytusmes methylatcd fur thc
four nonrral ceU lines ranged from 2.83 to 3.18, whrlc thc rangc lur the tuur SV4t1
transforracd cells was from 2.90 to 3.03. The mean (ur thc nNal nuuobcr uf HPLC
detcrminations was 2.94 ± 0.28(51 dctcrminatwns) fur thc nurm.l cvll ty(x.:nx13 t10
± 0.28 (53 dcternuna[ions) for the transformed lines. Thus, in axwa..t to whrr
12
rc{wutu) studics .uatparing normal and oncogcnically transf.uarcd cclls, no appareni
dtl lcrcncc was ot»crved in thc 5-rnethyky(osinc to cytusinc base ratius in the two ccll
types. It is worth cmplusrzrng that the IIPI.C method used here gives an absolute
measurc of the 1)NA bases. In addinun, the purity of the DNA is controlled by
urrritunng for thc prescnce uf uracil. Other methods using radioactive label may be
hinckrcd by. variuus dtflcrcnt artifacts.
Diala, E. S.. Plcnt, M. M., Coalsoa, D. W., and IIu,Q'man, R. M.
Biuc)rcmiraf and Biophysical Rrsrarch Carunwsicarions 102(4):1379-1384, 1981.
Otbar support: National /nstitutes of Hca)th, The United Cancer Courkil, Inc., TTe
Cancer Research Coordinating Committee of the University of California, the Aca-
dcmic Senate, University of California, San Diego, and the Leukemia Soctety of
Anscrrca.
From the Deparunent of Pediatrics, Univcrsity of California at San Diego Schoul uf
Mcdicinc, La Jolla.
CONSTITUTIVE BEHAVIOR OF METHIONYL-tRNA SYNTHETASE
COMPARED TO REPRGSSIBLE BEHAVIOR OF METHIONINE
ADENOSYLTRANSFI:RASE IN MAMMAUAN CELLS
Methioninc, because of its tules in protein synthesis and in mcthylation, is of
central unpurtancc to all cells. In the metabolic prucess, mcthtunmc can be used by the
cell through twu dtrfcrcm pathways: (I) nscthioninc can be cunverted to S-aJcrw-
syhncthtuninc, the ntajur medtyl source fur cellular uansmcthylation rcacuons ard the
source of the prrKrylarninc group for pulyaminc biosynthesa, or (2) it can be convened
to nscthiunyl-tRNA, an important inecrmcdiate in protein biusynthesis. In thc paper
prcscnted hcrc, it is rcpurted that rnethionyl-tRNA synthccase, unlike rnethioninc
ademrsyltransferasc, bchaves in a constitutive manner with respect to the concentratron
of methioninc in the culture medium. This behavior is seen in Chinc.c hamster uvary
cells and in normal diploid and SV4U-tsansformed hunun 6btublasts. Alahough the
kinetics of regulatrun of tncthioninc acknosyltranskrase and rncthiunyl-tRNA synthe-
tA.e by cxugenuus rncthiurtinc arc ckatly different, the levels of the two cazymes in the
human ccll lines arc similar.
Rubnitz, J. E., Jacobscn, S. 1. and Huffman. R. At.
Birr htmica tr Bwphystra Acra 677:269-273, 1981.
Other sapport: Nauonal Insntuics of Nealth. The United Cancer Cuun.'tl, bk , 71k
C'anccr Research Courdinaing Committee of the University ul' California. the A.a-
dcmic Senate, Univenrty of Califurnu, San Diego, and the Leukemia S.wrcty of
Amcrx a.
From the Dcprnn><nt of Pcdratrres. University of CalJornu at San Diego SchcKtl of
Muhctnc, La Julla.
13
FOLATE POLYGLUTAMATE AND MON(X;L(1-fAMA'1'I: AC'C UM(1LA'fIC)N
IN NORMAL AND SV4(1TKANSFOKMfiU IIUMAN I7BKO1)LA51:S
In the present attcmpt to asccrtain thc role of (utatc palyy.luumalcs in cell divi-
siun, it sccmul necessary fint w starvc the cclls of tulatcs uuJ cstnn.nc their total (ulatc
requirements for growth. AII four ccll lincs aurdtcd hcrc, the nunnal huu,rn dtpluirl
foncskin hbrrsblasl BA, the normal human fctal dipluid AF2. and the SV40-uan.-
formod lines P5 and PI, showed similar kinctics lur fulatc starvattun. Scpha.ka O-IQ
gel filtratwn chrumatogntphy was used to measure the k-cumulauun of h,latc 1>.dyglu-
tunate arKf rranoglutamat.e in all of these cell lincs. After the cells had bcen dcpletcd uf
folaru, they were provickd with lirruting anwunts of I'Hl-(uhc acid in order that tlk
cells wouW accumulue only forms uf fulate necessary litr pruhfcrauun. Buth the
nurmal aod the transformed cells accumulatcd nKmugluumatc and ptolygluwauutc
ftxrrrs, but by 72 hours of labeling. the ttansfurn><d cclb cuntairkd 3-Il) unks murc
polyglutanutc then the normal cells. Thc growth rates for the tMtnnal atxl lranslunncd
ccl(s were similar at this limiting folic acid conccmrauun. Thus, il' (olatc pulygluta-
nrates are more important for the prolifcrauun of SV4/1-uanstomxd cclls than thc
nrrrnal cells, the inhibition of polyglutarnatc formation could possibly be an tmpurtanl
potential target for chemotherapy.
llujjnrun, R. M. er ul.
Journal of Cellular Physiolugy 109:497-505. 19111.
Otltar srpporr: National Institutes of Health, The United Cancei ('riurw,I, hk'., TIh:
Cancer Research Caxdinating Comnuttee of the Univenuy of C'aldorrna, the Aca-
dcmic Scnate, University of California. San Diego. arxl the Lcukcmia Society of
America.
From the f1<partment of Pediatrics, Univcnity of Cahlumu at San Docgo Schuul of
Medicine, La Ju(la, and the Genetics Unrt, Children's Scrvtce. Massarhuscas Gcncral
fiospital, Department of Pediatrics and Center for Hunun Getx:tic., 1(arvard Medical
School. Boston.
DNA METHYLATION LEVELS IN NORMAL ANI)
CHEMICALLY-TRANSFORMED MOUSE 3T3 CELLS
-iltis investigation was undertakcn to assess the effcct uf chcmtcal trnn.funnanun
on wul gcrwmic DNA rnethylation as mcasured by high Ixrlunnarxc liquid cluumr-
wgr'aphy (HPLC). In the study presented hcrc, nunual nmnrx: cmbryu 3T3 cell cultures
and prose oacogcnically transformed by the chemical c:rrcinugcns IxniiNa)pyrcrk aud
rncthykholanthrene were analyzed by HPLC tu rktcmmrc the S-nkthycytn.uk to
cytosine base ratios in their total gcnumic DNA. Rcsults showed that the nKan hu 10
HPLC dcterminations uf the normal 3T3 cells was 2.1/TJ6 of cytusmes nuahylatcd with
a standard dcviation of s0.S8, while thal for the bcntt(a)pyrcnc-tran.funucd 31:3
cells and the methykhufanthrene-transformed 3T3 cells was 2.It11'i s U. 31 113 rktcrmt-
nationsl and 2.81'b 20.18 (IS determinatruns), respecUvcly. These rc.ults led tu thc
conclusirm that there is no real diffcrcnce in the catcnt of wtal gcnonu. UNA rnwohyla-
twn between normal and chcmically-uansformcd 3T3 cells whcn mcawrcd by I IPL('.
1)iala, (:. S. and lluf/nwn, R. M. C11z
lLiwhrtnicul und llmphysirul Rr.tnurh Cummunirutrun.t 1(ll(4/:(4K9-14'N, 1482. ~
Other support: National Insuwtcs of Ucalth, The Unitcd Cancer Cuuncil, Inc.. lbe TI
(']nlCr Kcxuch C00ndInating Cumnuttcc of the Univcnny u( Cahhnnta. the Aca-
rkm,c Scnatc. University of California. San Dicgu, and the Lcukcmia Society o(
Anknca.
Prum tlw lhpartn>Lnt uf Ncdiatrics. University of Calilurma at San Diego School of
Mcdkutc, La Jolla.
M6f111UNINE DEPENDENCE IN CANCER CELLS-A REVIEW
Mcthir>,unc dcpcrukncc uccun tn a largc numher and wide variety u( canccr cells
and dr>LS not xcm w be a random cumpuncnt of the transfurrncd phenotype. Dchnruun
ol' methiuninc rkpcr>d<.nce states that it is a defect found in many cancer ccll hncs that
inhibits their growth in culture when methionine is replxed by its imrncdiate precur-
sur, humr><ystcine, in the culture medium. Normal cultured cell. do nut have thts
dcfcrt. Tlris reprxt lists the diverse and large number of anunal and human cancer lines
that arc mcthiuninc-dcperwknt, and critically reviews the ccll biology and mclhiomne
birxhcnusuy of the phenomenon.
11u,0'mun, R. M.
In Vitru 18(5):421-428, 1982.
Olher support: National Inatitutcs of Hcalth, The United Cancer Council. Inc.. The
Canrer Keacarch Cr>,ndtnaung Crxtunutce of the Univcrsity af C.rltkxnu, the Aca-
demic Senate. Univcnity of Caldrunia, San Diego. anrl the (.cukemia Society of
America.
prruo Uw lkpanuwm of ('cdrautcs. Unrvcrsuy of Cahlurma at San Diego S:huul of
Mcd,ctna, la Jolla.
IIYI'OMETIIYI.ATION OF 11i:LA CELL DNA AND THE ABSENCF. UF
5 MI~fHYL(.'YTOSINE IN SV4U AND ADENOVIRUS (TYPE 2) DNA:
ANALYSIS t)Y 111'LC
In thc study presented hcrc, nxthylatiun of the punhcd viri.nt 1)NA uf b.,th SV4U
arKl .nlcnrrvirus (typc 2) wa. n>,'asurcd by high pcA,unt.rncc liquid c1u,MU.rtuKr.rphy
(IIPI,(') :url crnulwcd to tlkrr Mx.ts. Afrk:rn gr.rn ru,wtl.ry kidney ccllk and IkL-A
cclls, rca>lcuvcly. In SV4O DNA, as nwch as 12 na,MHmrks ul cytusmc has brcn
n,.a.urr:d without crNrcumit.tnt rkt.ctn,n of mCyt. $V40 iuruarns 27 C'p(i parnm
which ra tlk u.u.rl m.thylabuu sttc. II all Cp(i (t.rr% were nrcthylitcd. tho wuuW ytcW a
srgn,bcanr 1.3% rr>Lthylatron uf tutal cytustncs; Mrwcvcr, ut the vtnun DNA studt.d
here, nuru sccnKd tu bc n><thylatcd. Alsu, as with SV4U, m'C yt was mM present in the
15
14
ekµioa patscrn of virion adcnovinu (type 2) DNA basea. Ovcrall, essentially no 5-
methykytosine was ducctod in cithcr viral DNA. lmplicatiuns (ur viral gcnc rcgula-
lion by metAylatioa are discusscd herc. In comparison with normal human ccll DNA
mct(rylatioa kvels, liel.a ccll DNA mcthyluion is rc.luccd stgntficantly.
Diala, E. S. and !/o,Q'man. R. M.
Biochemical and Biophysical Rcsearch Communicutions 107(l):19-26, 1982.
Olkar sstipport: Natioaal IrWitutu of Health.
From the Dcpuvncat of Pediatrics, Univcrsity of California at San Dicgu School of
Medicine. La Jolla.
REDUCED AVAILABIUTY OF ENDOGENOUSLY SYNTIif:Sl"LI:D
METHIONINE FOR S-ADENOSYIvfEiH1ONINE FORMATION IN
METHIONINE-DEPF1dDFNT CANCER CELLS
Mcthioninc (Mcl) dcpendcncc-i.a, the inability of culturcd cells to grow when
Met is replaccd by its irrunodiate precursor hornocystcme (Met- Hcy' mca(wm)-is a
frequent component of the oncogcnically transformcd phcnotype. Normal cclls, on the
other hand, grpw in this rnodium. Thcnc have been reports 1Hof(man, R. M. & Erbc.
R. W. (1976) Proc. Natl. Acad. Sci. USA 73, 1523-1527; Hoffman. R. M., Jacobsen,
S. J. dc Erbc, R. W. (1978)Biochcm. Biophys. Res. Commun. 82, 225-2341 of normal
or Aighcs rates of Met biosynthcsis in Met-dcpcrrdem cells and a postulation that Mct-
dcpcndent cclls are dcficicnt in utilization of cadogenously synthcsrud Met as opposed
to cxogerwusly supplied Met. To rutswcr the critical question of what biochcmical
rcauion(s) requires prcfornrod Met in Mcl-depcndcnt cells, we labclcd cells with Mct-
troe IS1 i{cy or ('S) Met and dctcnnincd the kvels of Met. S-sdenosyhoetluunine
(AdoMU), and S-sdenosyRromocysteine (AdoHcy). We report hcre cxpcrinrents that
dcasonsocare that Met-dcpcrsdcal cclls synthesizc a rxxnul arrxwnt of cndugcmwaly
syatDcsizod Met and are deficient in utilizing this Met for AduMu synthesis. In
cootraat, exogcrsously suppliod Met is utilized normally for AduMct brusynthcsrs. The
ratio of AdoMet to AdoHcy is low in Mcldcpcndent cclls growing in Mct'tlcy'
nrodium. Wcducrminod that the low AdoMct/AdoHcy ratro probably lirnita growth of
Met-0epceduu cells in Mct-Hcy medium.
Coa)son, D. W., Mccham, J. 0.. Stern, P. H., and IloQman, R. M.
Proceedings of the National Acadenry of Sciences of the Unired Srutes of America
79:4248-4251, 1982.
O(Jssr srryport: Natioasl Institutes of Hca)th, The Univerauy Cancer Cuunctl, Inc..
The Cancer Research Coordinating Cornmrttcc of the Univcnity of California, the
Acadcmic Senate. UNvctsrty of CaJtfornrs at San DKgo. and the Lcukemra Society of
America.
From the Departnsent of Pcdiatncs. University of California uat San Diego Schr«d of
Modiciac, La Jolla.
VASCULAR INVASION OF CARTILAGE: CORRELATION OF
MOKPHOLOGY WITH LYSOZYME, GLYCOSAMINOGLY('ANS,
PKOTEASE, AND PROTEASE-INHllI1TORY ACTIVITY DURING
IiNDOCIIONURAL BONE DEVELOPMENT
Although it is well known that cartilage vasculanzation is a prercquuitc fur txxte
dtllcrcntiation, tlrc prcasc mechanisms of this vascularizatwn arc incompletely wxlcr-
strxrJ. In the ptcscnt attcmpt to study these changes. dcmincralrzcd bone matrix prc-
parul front rat diaphyacs was trsnsplanted subcutaneously into bilateral sites in the
thoracic region of 28- to 35-day old malc Long-Evam strain rats; the day of transplan-
uuon was dcsignateJ as Day 0. While using the rnatrix-induced endrkhundnl bone
ddfcrenuaticrn as a rnoJel systcm, changes in the kvcls of lysozymc, patterns of
glycosarnirurglycans, and actrvitics of protcascs and protcase inhibitors were studted
during matrix-induced carrilage, bone, and buttc marrow development The morpbo-
hrgtcal transitions were corrclatcul with the biochemical parameters. Rcsults showed
that thcre was a pcak in lywzynse content on Day 3. during mcsenchymal cell prolifcr-
auun, (ulluwed by a decline during cndochorx)rsl bone formation. The lysozymc levels
increased again and attained masimal values during hcmatopoicsis on Day 21. Pro-
tcasc-inhibitory activity was maximal during chorxLogencsis and drnunishcd during
ostcogcncsis. Prutcase activity was maximal on Day 3 during mescnchymal ccll prolrf-
«auon and was apparcntly prcscnt as an enzynre-inhibitor complex. Vasculanzatron
and bone formation were accompanied by an increase in protcase activity. Chon-
druitin-4-sulfate was the prcdonunant glycosaminoglycan detected in the nutrix-in-
duccd cartilagc and bone.
Reddi, A. 11. and Kueuner, K. E.
Developmentul Biology 82:217-223, 1981.
Other supporr: National Institutes of Hcalth.
From the Laboratory of Biological Structure, National Institute of fkntal Rcsearch,
National Institutes of Health. Bcthexla, MD., and the Depanmcnts of Onhopedic
Surgery and Ihochetnrstry, Rush-Presbyterian-St. Luhc's Medreal Ccntcr, Chicago.
RESISTANCE OF CARTILAGG TO INVASION
In this cxtensrve and cucfully workcd-out chaptcr, a simplified conccpt of the
invaaivc procc» is intruduccd, and a unique sequence of cvcnts occurring during
physiologic (emkxhelial cells) and paehologic (ostcosarconu cclls) invasion is
dcscnbuf. The term invasion, as used here, is dchncd as the pa»rng, rntcrpencuatrun,
of infiltration of cells into ad)acent tissues. The events that characterize this prrrccss
have been studicd in vuro in a combincd organ-ccll culture syucm consisting of
marnalian hyalinc cartilage and TE-85 osteosarcoma cells. Cartilage was ab-e to reaist
the invasion by uateusarconu cclls in the organ-cell culture system. Ostarsaramu
cells forced to grow in direct contact with the cut surfaces of articular hyalrnc cartilage
pikd up to sevcral cell layers, but were unable to penetrate the canilagmous nutnx. In
vivo. similar reatrictiona of cantlagc to tumot cell invasion havc been rc(xxtcd in
ptinury and n><tastalic tumors. Also, cartilage is thought to be resprmatbk for the slow
invasion of carcrnuma cells into the walls of the larynx. Spccihc studies reprwred here
shuw that hyilrnc canilagc, mddly cxuarted with vatiuus salt auluriuna, is readily
ieGltrated by uateuaarcunu cells in the urgan-eell culture system. These lmdmgs kd to
16 17
th.: conclusion thar canilagc cuntatns caraelahlc matrrs .anqxrunJs that inlnhn inv.r-
rc
sNm in an e apenmental system. W frcn these Ji((usahlc and c s tra.-tahtc subslarrccs wC
further studicd. it was found that the inhibition ul ostcrrsarconra cell pruhfcnuon was
caused by nwkcuks with a molecular weight of less than 50.1(X) Jaltotu. From thu
anti-invuive factux of the canilage extract, a prutcasc inluhitur was irknNlic.l that has
tbe ability tu inhibit nuntalian collagcnast, InCludlnl7 that CIaMnBICJ by UNtCoAarlUnra
cells And errdWlwlial cclls. These espcrmwntal data led ar tlrc hylartlresrs that rnv.rsrun
of citlx:r wrnrx tx endothchal cells depcnds on pruteulyu. (<nll.rgenulyuc) cniyme
xtivities. Other studies along these hrres havc Ixen in.ntutcJ tu lidluw the rnvasrvc-
ncss and proliferation of bladder carkcr.
Krurtnar, K. E. And Pauli, fl. U.
In: Gilben. ff. A., Wciss, L. and Monscn, D. C G. /eJs>: Rrrnr Alrtu.rru.rr.r, lsustom:
G. K. Hall Medical Publishcrs, 1981, pp. 131-Ib5.
Otbsr srrppat: National lnstitutes uf Health.
From the [kpartrnents of Orthopedic Surgcry, Pathology and l)io<Ikmutry, Rush-
Presbytcnan-St. Lure's Medical Centcr, Chicago.
ANTIINVASION FACTOR MEDIATES AVASCULARITY 01: IIYALINE
CARTILAGE
To test an aruiinvasiun (actor (AIF) hyputlxxsis uf Q>t resutarwc u( canilag. to
vascular rnvrsion, a novel in vitro system was surdicd that cmpluycd twvuu ua: ular
canilage as a growth surface for normal hcparin-stimulatcd endrxlxbal cells. In (hrs
study, cells were tested for their ability to invade the matns uf viable urd Jcvitalv.cJ
extracted cartilage as monitored by thin-sectwn ckctron mtcruscupy. The growth
bchavior of cells on rkvitalized extracted cartilage was cxamirred in the prcxnce anJ
abserrce of cartilage-dcrived, extractabk AIF in the culture medrum. Whereas nor-
mally viable anictrlu cartilage is a poor growth surface for crrdutluhal cdls, the
eodothelial eells studied here, in contrast, grew as cuntact-inhrbitcd nwnulaycn u(
flattcned cells on the surfaces of extracted cartilage. The cells were +cparatcJ Iruur the
cartilage matrix by rrbundant basal lamina. lbcrc were a few rnicruvilli at the basrl
plasma merrrbrane, but thcrc was no dcgradation or pcrutr.nun u( the cullagcnuus
mauix uf extracted cartilage. Huwtver, when endutfxlral cells were sunrulatcd by
heparin, they aswmtd a polyhedral shape and perktratcu thc extrxtcJ canilagc wu;r
numerous mierovilli and some cytoplasmic processes. Thrs penetration ul tfic tulla-
gcnous rrsasna was associated with tissue rarclaction and degradation ol collagen
fibcrs. lnrportandy. howevcr, this invasion of hcparrn-stunulatcd a>,kdhclral cells wns
abolishe.J when low concentrations of canilagc-deriveJ AIF werc added tu tik culrurc
medium. These data provide evidence that the resrsurrKC uf hyahrrc cartilage to cn-
duthclial cell invasion is regulated in pan by tissue JenvcJ prutcin+ac rnhrbuurs anJ an
arstiproli(erative activity direeted against errduthehal cclls.
Krrrrtrrtr. K.E. er d
Scnrinurs in Arthritis 6 Rhtrurwpsrrr 11:67-69, 19Z<1.
Ot/ur srroPort: National Institutes of lkalth.
From Rush Medreal Culkgc. Chicago.
1>S
CUAKACTIiKI-LATION OF ADULT BOVINE ARTICULAK CliONUROCYT(iS
IN CUL'1-UKE
Anrs:ular cartilage sliccs, obtaincJ from 1g-mrr-ulrl brrvrnc metacarprsphalangcal
juints, were used as source nutenal (or this rkscnprive articlc ol eMrnduxytes in
culture. A(tcr sequential digestion and hlu.tion, .clls wcrc plated in either nssue
cuhure Jrshcs or ruller IxNtks. ChurrJrucytes fixed in bulfcrcd glutarakkhyde corrtain-
ing 0.1% rullKnlum rcJ, were examined by light And transmr.sn>rr electron mkru-
srupy. Cullagcn lype dclerrninalron of 7l-prohnc-labekd pnrtcins iwlated frunt
culrures were IvrlurnkJ by clcctropMxctic and CN(3r pcpridc analyso. (Siu.ynnccsis
of protcuglycrns was nrcasured by "JO, rncurporatrun into macromulccuks cxtrxtcJ
under drssur:iauvc conditions. Eaaminatton showed that iwlatcJ chundrucytc. prior to
culture were typically rounded with scanl territorial matrra, which could be removed
by mild trypsiniiation. Throughtwt the progressiun of the cultures, phcnutypw alkra-
buns were mN observed. Ekctrofluorugraphs of collagen tfut was exxracted Irrxn I f-
prulhnc-labclcd cultures after mild pepsin digestion showed I band in the position of the
aI chain; an a2 chain could rrot be detected. Cyanogcn bromide pcplidc analysrs
confimxd that the majur radioactive peptides eornigrated with unlabeled peptides
obtained from type 11 collagen- type I collagcn was nut dctectabk in these . ultures.
Prutcoglycan aggrcgatc was extracted from both culture Jishcs And roller bottle cul-
tures, under associative conditions. There were dif(ererrres noted in this cxpcnment
suggestmg that the roller culture ccll-associatcJ matrix may hase a greater rkgree of
txganization than that grown in standard tissue culture drshcs. Thcse samc data also
indicate that articular chorwlrocytcs grown in mass rullcrcultures are capabk of synthc-
sizing a plremrtypically stable, tiuuc-like matrix in viuo.
Kwttrner. K. E. tr ul.
Srmrnun in Anhrrus 6 Rhtumurisnr 11:101-103, 198 1.
Odur supporr: National Institutes of Health.
From Rush Mcdical College and the University of Illinur. Dental S:h.w1, Chrcagu.
KLGUI.ATIUN OF TUMOR INVASION BY CAKTILAGE-t)ERIVED
ANTI-INVASIUN FACTOR IN VITRO
Mamrnaltan candagc is highly resistant to invasion by tunwr irll. TTrr. reast-
arkc was studied hcrc with the usc uf a novel in vurr.:ullure sysrcm. Anrculu:anilagc
obtained Irum Iresh nrctacarlwrtralangcal jornts ul prcaJrrlcsarnt twvuks was uxda. a
gnrwth surfacc lrrr huuran TE-g5 ustcusarcoma cclls and hrreskrn hbrubla.ts. ('artrlagc
drsAs furmeJ t1k bullunn of stainkss-sleel cylrndera, providing cluscJ growth charn-
hrrs for these cells. Hnlh invasive ostcosarcuma rclls And normal hbrubla.ts were
unable tu pcnruatc vobl., uneatracted canilage during a 2-wecl cuhure pcrMrJ Wlno
cartilage was JcvntalucJ by lrcctrng arxd thawrng, the trssue renr.rrncJ resutanl to
invasion Cutrlagc, extractcJ with either I or 3 M gu.worJrnc hydnMhkrrrde, was
invar)eJ by ost.usarcrtina cells. but nrM by control bbruMasu. Inva.arn by usteosar-
cunra cclls rnlu salt catrx'tcJ cartdagc was ahuhslrcJ wlrrn low c.xr.rnpatnrns u( a
cartrlage-dknveJ, anu; rnvasaxr (actor were adrkd to the culture nreJrunr. These data
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