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THE COUNCIL FOR TOBACCO RESEARCH-U.S.A., INC. January 9, 1992 GRANT APPLICATION NO. 1475CR1 CANCER TO: The committee comprising Drs. Brennan and Sato SUBJECT: Eric Stanbridge, Ph.D., University of California Irvine, Irvine, CA lst Renewal Application No. 1475CR1 "Interactions between Oncogenes and Tumor Suppressor Gene in Cancer" HISTORY This application was not considered as a case. Dr. Stanbridge has received from CTR since 1982 (1475: Transfer of S?ecific Individual Human Chromsomes to Recipient Cells" Support has continued through various title changes on investigations dealing with oncogenes and cancer. The present program, entitled as above was initiated in July of 1991 wherein $110,000 was requested for the Ist year and $118,248 and $127,040 for years 2 and 3 respectively. The application was approved at the April 1991 SAB meeting and funded for $90,000. REQUEST Application No. 1475CR1 requests $112,994 for the second year of this three year program. DOCUMENTS SUBMITTED (ATTACHED): 1. Application dated 11/12/91 (8 pages) 2. Progress Report Abstract for the period 7/1/91 - 11/30/91 (1 page) 3. Reprints ( 3 in number, all acknowledge CTR) COMMENTS As progress appears to be satisfactory this application will be handled administratively and withheld from the bulky SAB agenda for the April 1992 SAB meeting, unless you object. In this case your written comments will be appreciated, and, for your convenience may be noted on the check-off sheet. Please return the check-off sheet at your earliest opportunity. DONALD FORD DF/mla