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Smolensky, M.H. and G.E. D'Alonzo. Medical chronobiology: Concepts and Applications;- N. o.Eturnal Ast.hma, R. Martin (ed.), Futura Pub. Co., N.Y,, pp. 1,23, 1993. • SmolEnsky, M.H. and G.E. D'Alonzo. Biological rhythms and medicmious: Chronopharmaco!ogy and chronotherapeuties. Nocturnal Asthma, R. Martin(cal.), Furors Pub.. Co., N.Y., pp. 25-69, 1993. D'Aionzo, G.E. and M~H.' Smolensky. Chronobiol0gy and chronotherapy of noctttmal asthma, Brit. I. PharmaEol. in press (1994). D'Alonzo, G.E., M.H..Smoleusky et al. Batnbuwrol .in the treatment of asthma: a placebo-controlled comparison.of morning versus evening administration. Chest in press (!994). Smolensky,. M.H~ and M..Weber. Chronotherapy of mild hypertension by evening verapamil~ GITS. In preparation, JAMA (1994). SELECTED EARLIER FUBLICATIONS:- Smolensky, M.H., I.A. Kraft, R.B. Sotheru, T.D. Down, C.W. Eiflcr and E.A. Mealy. : Circadian rhythmicity'in pulse rate and duration of cardiac cycle (P-P interval) in donor and recipient cardiac tissue of heart homograph ~afiEnts. Texas Reports o_..~n Biolo~,y-and Medicine 33(4):533-548, !975, SmolEnsk'y, M., S. Samueloff, B. Harlevy, E. McDonald and A. Reinberg; Circannual rhythm of cardiac motudity: An anempt to identify possible endogenous and exogenous factors. Israel _J. Med. ScL I2(8):818-827, 1976. Cech, I., M.H. Smoleusky, R, Lane, B. Harlevy andS. Samueloff. Biometeorologic aspects of short,term fluctuations of. cardiac mortality in Jerusalem and Tel-Aviv studied by lagged cross~ovariance analysis. Israel J. Meal. Sc..~, 12(8):828,831, 1976. ,. Smolensky, M,H., S.A. Bergman, C.N. Baruard, W. Beck and I. Kraft. Circadianrhythmic characteristics of innErvated and non-innerw_t_,M cardiac tissues of single and double-heart trausplanted patients. Cardiovascular Bulletirh Texas Heart Institute 3(2): 150-168,. 1976. Ccch, I., and M.H. Smoleusky, Daily and seasonal card.iovascular mortality patterns in Houston. Cardiovascular Disease Bulletin, Texas Heart Institut~ 3(4):370-381, 1976. Harmng; H.O., M.H. Smoleusky, R, Harrist and C. Skrovan. Effects of varied durations of physical training on improvement in cardiore.spiratory endurance. J. Human E~ol. 6:61-68, 1977. SmolEnsky, M.H., S.E. Tatar, S.A. Bergman, J.G. Losman, C.N. Baruard, C.C, Dacso and I,A, Kraft, Circadian rhythmic aspects of cardiovascular function. A review by chr~.nobiologic statistical methods. Chrono~ 3:337-371, 1977. Smolensky, M., J. Jovonovich, G.-Kyle and B. Hsi. Chronotoxicity in rodents challenged with propranolol HCL (Inderal). In: .Chronopharmacolo~,, A. Reinberg and F. Halberg (eds.). Pergamon Press, Oxford, 1979, pp. 263-271. Smolensky,.-M.H., A. Reinberg and J. Queng. Chronobiology and ¢hronopharmacology of allergy. An~. 47(4):234-252, 1981. . ~.cinberg, A., M.H. Smoleusky and F. Levi. Therapeutic implications of time dependencies. In: Topic.s. Pharmaceutical .Sci.ences 1985, Elsevier Science Publishers B.V, (Biomedical Division), 1985, pp. 191-205. Reinbcrg A.,.M.H. Smoleusky and G. Labrcc.que; New aspects in chmnopharmacology. Ann. Rey. Chronopharmaco.l. 2:3-26, 1986. Smolcnsky, ~M.H., P.H. Scott and W. Kramer. Clinical significance of day-night differences in serum the.opb~ii:;. -. concentration with special reference to TheoDur. ~. Allert, v C!in. Immun01. 78: 716-722, 1986. Smolensky, M.H;, P.J. Barnes, A. Reinberg and J.P2 McGovcrn. Chronobiology and asthma. I. Day-night differences ., in bronghial patency and ~yspnes and circadian rhythm dependencies. J_. Asthma 23(6):321-343, 1986. RandEm, B., M.H, Smolcusky, B. Hsi, D..Albdght and S. Burge. Field survey of circadian rhythm in PEF ofclectronics workers suffering from colophony-induced asthma. Chronobioioev Internat'L 4(3):263-272, 1987. Smoleasky, M.H.,$.P. McGovern, P.H. Scott and A. Reinberg. Chronobiology and asthma. II. Day-night differences in the kinetics.and effe~ts ofbronchodilator medications. J. Asthma 24(2):91'I34, 1987. SmolEnsky, M.H. Chronobiology and epidemiology.. Pathol. Biol. 35(6):991-I004,-I987. Rcinberg, ~., M.H. Sulol~.asky,. G. I~brecque and M~ Hallek. Aspects of chronopharmacology and. chronotherapy in • . children, Chronobiologia 14:303;325~ 1987. Rcinberg, A., M.H. Smoleusky,. G..E.~.~D~_~Alonzo aad J.P. M~;Govera. C'm'uaoblology and asthma. I'~. Timing corticbtherapy to biological rhythms to optimizetreatment goals. J. Asthma 25(4):219-248, 1988. Smolensky, M.H. Medical chronobiology. Amer.. J_. Medicine 85(Suppl Ib): 34-46, 1988. Albright, D., A. Voda, M.H. SmolEnsky, B.P: Hsi and M. Decker. Circadian rhythm in hot flash in natural and surgically induced menopausE. Chronobiol~ Intcrnat'.l. 6:279'284, 1989.

. BIOGRAPHICAL SKETCH . ' Give the following information for the key personnel and consultants and collaborators. Begin with the pnncipal investigator/program director. Photo<mpy this page for each person. NAME i[ POSITION ,ll ~~SCO PORT~PI ~ H~ of H~m¢~ion Unit EDUCATION. (B~in ~th ~umate or o~er i~al pmte~onal ~n, s~ ~ ~, ~ ~ ~s~ml ~.} ~R INS~ON AND LOCATION DEGR~ . CONFERRED RE~ OF STUDY O~ Forest no~i~, ~nicago M~ Sch~U ~niv.ofHeal~ Sciences, Chicago, Illinois~ USA. g~se~h F¢11o v 1979/80 : ~olo~ RES~RCH AND PRO~SSION~ ~PERIENCE: ~ng .~ ~ese~ ~n, ~ ~ ~m~i~l o~er, ~ous emplo~nt, ex~ence, ar honom. Key ~nnel in~ ~e pd~ ~e~gator ~ aw ot~r t~ ~ ~e in ~ ~e~fic ~etop~m or ex~ion of the projec ~laureate I~el p~d ~ey ~e ~ a s~ ~y to ~ ~ de~nt or exxon of the p~. I~ wesent mem~rship c "any Federal G~emment public a~ ~m~. ~L ~ ~mno~l ~r, t~ psst thr~ yearn and to represen~ ea~er ~bli~o~ ~nent to t~ ~pli~n. DO NOT ~CEED ~':~ PAGES. ~cwer for ~cy ~tcmafion~ P~ERS D~ING ~ PAST ~ ~ARS 1, Po~uppi F, Momm~ L~ Mm~ M, Di Chi~ V, ~pmna M. ~ss of nocmm~ dectin~ of bI~ 2. Po~uppi F, Bali B, ~v~ AR, ~s~si M, V~pon~ a~ na~u~fic pepfid~ ~ in~ ~ no~otensive pos~nopaus~ wom~n ~ a function of ag~. ~olo~ 1991;78(4):317-322. 3. Po~aluppiF~ Mon~ ~ Ver~mi L, degli U~ E. ~f~ of ~ conv~ng enz~e inhibit~ qu~ap~ on autono~c function in no~otensiv~ ~ ~ssenfi~ h~nsiv~ subject, C~ ~er Res 1991;50(2):231, •.238. 4. Po~uppi F, Momm~ L, F~Ii~ M, ~mi L, D'Am~osi A,~v~ini AR, Bali B, deg~ Ube~ E. Consis~em chmg~s in ~ ~~ ~~ of bl~ p~ss~ ~d a~ h~ f~I~. C~onobiol ~t 1991;8(5):4~2~39. 5. T~fofini G, M~ A, Po~uppi F, Menega~ M, ~b~sio MR, Bali B, Pmsini R, D~g~ ~ EC. 1991;73(5):945-951. " 6. Po~uppi F, Mon~ L, y~i L, T~ G, ~v~ini AR, G~i P, Bali B, deg~ ~ EC, ~ss of n~ ~¢ ~ pl~ con~n~on of a~ na~c p~pfid= ~diolo~ 1992;80(5-6):312-323. 7. P~uppi F, Mon~ ~ F~lini M, Vcr~i L, Bali B, Dc~ ~ EC. Differences in bl~ ~ssum m~lafion of congCsfiv~ hc~f~, ~f~ ~d ~t~ ~cn~ ~lam ~ ch~g~s h ~ c~a~g patt~ of a~ na~fic p~pfid¢. E~ H~m J 1992;I3~):99~996.: ~. Dcgli U~ E~ S~v~o~ S, T~fofini G, M~ A, Am~sio ~, Rossi R, Po~luppi F, P~shi R. Effect of dclto~hin on ~~-~ m@onsc to insuHn-hduc~ h~oglyc¢~ ~d o~nc c~co~ph- ml~ing ho~onc in h~thy ~. J Oh End~nol M~ 1992;75(2):37~374. 9. Po~uppi E, T~fofini G, ~~ A, V~r~i L, Am~sio u~m EC. C~--~.~m of C~cito~n gcn~-.mht~ ~pfide h uncomp~cat~ essen~ h~enensiom J H~en~ns 1992; 10(10): 1227't2M. 10. Po~uppi F,. Con~11i P, Avoni P, Sfo~ E, Vcr~L, degH Ub~ EC, Lug~csi E. C~c~ ~~ of bl~ pressure ~d hc~ mt¢h fa~lf~ inso~ ~ htc~s~pl. Cycle Rcs 1992;23(3):227-~9~ 11. degli U~.EC, S~vadofi S, T~fofini G, M~ A, Am~osio MR, Rossi ~ Po~uppi F, Vcrgn~i L, P~sini R. ~-Opioid rcceptom ~d ~e s~cfion of ~w~ ho~onc (GH) h ~: Effect of opioid ~-mccpmr (15)'

agonist deltorphin on GH responses to GH-rclcasing hormone and insulin-induced hypoglycemia. Neurucndocr/nology 1992;56(d):907,912.. 12. Fontani G, Vergnani L, Salvadori S, Voglino N, Aloisi AM, Portaluppi F,degli Ubcrti EC. Effect of dermorphin on behavior and hippocampal electrical activity in rabbits, Life $ci 1993;52(3):323-8. 13: Fontani G, Vergnani L;Salvadori S, Voglino N, Aloisi AM, Portaluppi F, Degli Ubcrti EC. Effect of deltorphin on behavior andhippocampal electrical activity in mbbits.Physiol Behav 1993 Feb;53(2):285, 90. 14. Portaluppi F, Vergnani L,' degli ~ EC; Atrial natriumtic 1~ptide and blood pressure regulation. Clues ¢'~ from a chronobiological approach. Chronobiol Int 1993;10(3):176-189. LL~I 5. Portaluppi F, Vergnani L, Margutti A, ,Ambrosio MR,.Bondandli M, Trasforini G, Rossi R, Degli Uberti ~ EC. Modulatory effect of the renin-angiotcnsin system on the plasma levels of calcitonin gone-related pcptidc in normal man, J C1in Endocrinol Mctab 1993;77(3):816-20; ~¢~I 6. dcgli Ubcrd EC, Ambr0sio MR,Vcrgnani L; Portaluppi F, Bondanc.Ili M, Trasforini G, Margu~ A_, ¢-~ Salvadori S. S.tress-induccd activation of sympathetic ncrcous system is attenuated by the selective d .-opioid receptor agomst dcltorphin in healthy man. J C1in Endocrinol Mctab 1993;77(6): 1490-1494.. Zi7. Portaluppi F, Cortclli P;,Avoni P, Sforza E, Vcrgnani L, dcgli Ubcrti EC, Lugaresi E. Loss of sleep activity and cimadia~, rhythms of blood prcssurcin fatal-famflird insomnia. J Hypcrtcns 1993; 11 (Suppl: 5):$469-$470. ~18.Trasforini G; Margutti A, Vergnani L Ambrosio MR, Valentini A, Rossi R, Portaluppi F, degli Uberti EC. Evidence that enhancement of cholinergic tone increases basal plasma levels ofcalcitonin gene-rdated peptide in normal man. J Clin Endoerinol Metab I994;78(3):763-766; ~19. Portaluppi F, CorteHi P, Avoni P, Vergnani L, Contin NL Maltoni P,Pavani A, Sforza E; degH Uberd EC, ~, Gambetti P, Lugaresi E. Diurnal blood pressure variation and hormonal correlates in fatal familial insomnia • Hypertension 1994;23(5):569-576. ~20. Portaluppi F, Cortelli P, Avoni P; Vergnani L, Maltoni P, Pavani A, Sforza E, degli Uberti EC, Ga~abetti "1". P, Lugaresi E. Progressive disruption of the circadian rhythm of melatonin in fatal familiai insomnia~ J Clin. I'-" Endocrinol Metab i994;78(5):1075,1078 ~21. Manfredini R, Gallerani M, Porraluppi F, Salrni R, Chieriei F, Fersini C. Circadianvariation in the occun'ence of paroxysmal supraventricular taehyeardia in elinieally healthy, subjects. Chronobiol Int ~. 1994;11:in press. .~__. Portaluppx 1::, Manfredim R, degh Ubertx. EC, Fersmx C. Time-dependent effect of isradipine on the i-- nocturnal hypertension of chronic renal failure..Am J-Hypertens 1994;7:in press. .~. REPRESENTATIVE EARLIER PAPERS Lid 1. Portaluppi F, degli Uberd E, Strozzi C, Margutti A, Montanari L, Rambaldi R, Trasforini G, Pansini R. 03, 10: Slow,release nifcdipine: effect on the circadian rhythm of blood pressure in essentinl hypertension. Acta Cardiol 1987;42(1):37-47. Portaluppi F, Stroz.zi C, degli Uberti E, Rambaldi R~ iTrasforirti G, Margutti A, Montanari L, Fersini Pansini R. Does placebo lower blood pressure in hypertensive patients? A nordnvasive ehronobiologi.cal. study. Jpn Heart J 1988;29(2):189-197. Por-~aluppi F, Ml?ntanari L. Consistency of circadian blood pressure pattern assessed by non-invasive monitoring and eosinor analysis in hospitalizedhypertensive patients. Acta Cardiol 1988;43(5):605-613. Portaluppi 1=, Montanari L, Capanna M; Ferlini M. Chronobiologie vs. sphygmomanometrie assessment of hypertension in a hospital setting. CIin.Cardiol 1989;I2(7):380-383. Portaluppi F, Montanari L, Bagni B, degliUberti E,, Trasforini G, Margurd A. Circadian rhytbm-~ of atrial natriuretie peptide, blood-pressure and heart rate in normal subjects. Cardiology 1989;76(6):428-432. Portaluppi F, Montanari L, Feriini M, Capanna M. Are we overtreating hypertensive patients? Chronobiologie vs. sphygrnomanometrieevaluation of. ambulatory antihypertensive therapy. Jpn Heart J Portaluppi F, Bagni B, degli Uberti Zasiella M, Patti M. Circadian rhythms, of atrial nawiureti'e peptide, renin, aldosterone, cortisoi, blood pressure and heart.rate in normal and hypertensive subjects. J Hype=ens" 1990;8(1):85~95: Pormluppi 1=; Pradella A, Montanari L, Degli Uberti E,-Trasforird G, Margutti A, Cavallini AR, Bagni B. Atrial strain is the main determinant of release of atrial natriuretic pepfide, Int J Cardiol I9.90;29(3):297-303 PortaluppiF, Montanari L, Pansini'K-:-~f-fects of the converting enzyme inhibitor quinapril on the circadian rhythm of blood pressure and heart rate in essential hypertension. Curt Ther Res 1990;48(4):613'622. Pomaluppi F, Montanari L, Ferlini M, Gilli P. Altered circadian rhythms of blood pressure and heart rate in non-hemodialysis chronic renal failure, Chronobigl I~nt 19c~9;7(4):321-327.

,The New. York-, Ac.ademy of Sciences FoundinqT Membership~ and Independence The Academy, founded in 1817, ~is now in its 1.79th year. It is the third oldest scientific society in Amedca andone of New York City's oldest and ._roost endudng cultural institutions. The Academy's mission includes complimentary commitments to science and. society through ,leadership in both ideas and in. programs of action. In service to science, it will sharpen its efforts to facilitate exchanges among scientists in New York and around the wodd. In service to society, it is expanding its activities in public communication, policy-debate, and science education to illuminate and improve the quality,timeliness, and reliability of contributions .of science to global social and economic progress.- Today, it is an international.organization with over 43,500 members .in more than 150 countries-nearly fifty percent of whom reside outside the United States. With a balanced annual operating budget of just under $10 million, and little governmental support, the Academy has an unusual degree of independence. Plans for the 1990s In December 1993, the Academy's Board of Governors adopted a strategic plan that builds on and expands the Academy's position at the intersection of science, business, education, health care, and government. In December 1994, the Plans were reviewed and updated with clear priorities and action plans. Conferences and Publications Approximately 20-30 scientific conferences are held annually in locations around the wodd. A new emphasis on presenting the metropolitan region as a global science .and technology center is resulting in more conferences, being scheduled in New York. Conference proceedings are published in the Academy's Annals, which are among-the oldest (172 years) and most frequently quoted sources of scientific research, About 30Annals are distributed each year to more than 745 libraries and to tho'usands of scientists and engineers worldwide. Additionally, the Academy publishes The Sciences, a bi-monthly magazine with a circulation Of almost 75,000. The Sciences has earned many national awards for scientific and artistic distinction in presenting scientific information to an educated lay public. W'~h a lead grant from the Esther A. and Joseph Klingenstein Fund, the Academy will issue a sedes of .publications on science policy issues drawn from meetings .of. its Science, Policy Association. Science Policy and Economic Development~ Since 1985, the Academy has sponsored a Science Policy Association that brings together leaders of business, education, philanthropy, the-professions, policy, makers, government officials, scientists, and engineers to discuss policy-related issues at the intersection of science, technology, education, and economic development. Scienceand technology serving economic development--in the New York region as well as in national and global policy-is a rising pdority of the Academy. Through policy analysis and through outreach, prestige, and the ability to convene experts from a vadety of disciplines, the Academy aims to share experiences, problems, and solutions. K-12 Science and Math Education The Academy's programs support science teachers and teaching in the City~s-and the region's-public, private; and parochial~ schools. They encourage about 3,000 students and teachers to do science, provide internships in corporate,=govemment, and other laboratories, encourage achievement through the Academy's six annual Science and Technology Expos for students in grades 5-12, and seek to advance public awareness of science, technology, and issues such as infrastructure and competitiveness. The Academy recently published the. first directory of professional science and educational development opportunities for science teachers and is looking =to design and implement.a new series of initiatives for teachers. Our education priorities are motivation and presentation of opportunities and initiatives leading to a more scientifically literate and prepared workforce. We bring the talents of scientists, social scientists, and engineers to.the K-12 education process as mentors for students and teachers, and as catalysts for improvement and change in science education in the City's public schools~ A Junior Academy for high schoo.I students was establishedjn---¢963 and now has about 1 ;000 members.

Science and Engineering Across Disciplines Differing=from traditional professional organizations, the Academy seeks to function at the intersection of disciplines and issues. :Through sections in twenty-four scie.ntlfic and engineering areas, the Academy provides continuing education opportunities whereby scientists meet with the leaders in their, and other fields. More than 180 meetings of scientists and engineers are held annually atthe Academy's headquarters. Sections on Science Education., and on Women in Science, cross all disciplinary boundaries to focus on opportunities and special needs in these crucial areas. Section meetings are open to the public without charge; The Lyceum Club ~ In 1993, the Academy sponsored the foundingof the Lyceum Club, a program for retired .and semi-retired Academy members that provides daytime discussion programming and a talent bank of highly skilled individuals whose services are available to school, non-profit, for-profit, and government agencies. Human Rlqhts of Scientists The Academy has an active program which promotes the human rights of scientists; physicians;-engineersl= and educators irrespective of the political or economic policies of the countries in whiohsuch individuals reside. The Academy ~was credited by Andrei Sakharov and Fang Lizhi with coordinating the international pressure that led to.. their reiease.~ Both made their first U.S. appearances at theAcademy. Today, w~th the Committee of Concerned Scientists, the Academy is assisting emigree scientists from the former Soviet Union, the Peoples' Republic of China: and other countries to adjust to and find positions in the U.S. while simultaneously working on behalf of scientists worldwide to ensure the free pursuit of scientific careers and free expression; And we continue to work on behalf of scientists such as Vii Mirzayanov of Russia, whose work to eliminate chemical weapons testing has proved the role of.the new Russian constitution. The Gallery of Art and Science ~ In fall, 1994; the Academy formalized its longstanding exhibition program of artand science with the appointment of a curator and establishment of an alliance with the State .University of New York at Binghampton. The opening exhibition, Madness in America, received an enthusiastic and extensive review in The New York Times. Programs change throughout the year; the public is invited without charge.. ~ The New York Academy Of Sciences - orqanization, support, and leadership The New York Academy of .Sciences is located at Two EastSixty-third Street, New York, New York. Open to all who. are interested in science, it-is a non-profit 501(c)(3) supported by membership dues, publication and .magazine sales, and from the gifts of corporations, foundations, members, and friends around the wodd, It sponsors a thriving Corporate Membership program, and collaborates with corporation, foundations, individuals, and other organizations in presenting science-based programs for the public good, The Academy has a Board of Govemors of distinguishe~! individuals from all sectors. The Board, and the Academy's president, chief executive officer, and staff benefit strongly from the President's Council which is comprised of individuals, of extraordinary, accomplishment and with broad expertise who are chosen for their leadership in,fields important to the Academy's mission. Academy committees draw heavily on leaders from business, education, and the non-profit sector, advancing the Academy's work as thecenter where people, ideas, and issues in science and. technology-based social and economic development converge. (18) 2/95 =

THE NEWI YORK ACADEMY OF SCIENCES Chairman of the Board Joshua Lederberg Raymond & Beverly Sackler Foundation Scholar and University Professor The Rockefeller University 1230. York Avenue New York, NY 10021 President Dr. Henry M. Greenberg • Associate Professor of Clinical Medicine Columbia University College of Physicians & Surgeons and Director, Coronary Care Unit St. Luke'skRoosevelt Hospital Center 425 West 59th Street New York, New York 10019 President-Elect Dr. Martin L. Leibowtiz Managing Director Salomon Brothers, Inc: 7 World Trade Center 41 st Floor New York, New Yorl~ 10048 Treasurer Mr. Henry A. Lichstein Vice President Citibank, N.A. 399 Park Avenue New York, .NY 10043. (19) . • Phone (_1_~ 2 [:.a~t t~3rd Street. New ~'~rk. NY 101121 • ~ ~ ,~3,~-0230 • Fax t212) 838-5640 • Cable NYACscI "

Governors Dr. Eleanor Baum Dean, School of Engineering The Cooper Union 51 Astor Place New York, New York 10003 o Dr. Barry-R. Bloom Professor, Weinstock Professor Department of Microbiology and Immunology Albert Einstein College of Medicine 1300 Morris park Avenue Bronx, NY 10461 Dr. D. Allan Bromley Professor of Physics Yale University New Haven, CT 06520 Mr. Edward Cohen Chairman,-CEO, Managing Partner Ammann & Whimey; Inc. 96 Morton Street New York; New York 10014,3309 Dr, Susanna Cunningham~Rundles Asso'eiate Professor of Immunology Comell University Medical College 1300York Avenue New York, New York 10021 Mr. Bill Green .... Director N.Y.C. Housing Development Corporation 75 Maiden Lane New York, NY ~10038 (20)

Governors (cont.) Sandra Panem Managing Partner Vector Fund Management L.P. 17-51 lake Cook Road Suite 350 Deerfield, IL 60015 Dr. Richard A. Rifla'nd Chairman, Sloan-Kettering Institute Memorial Sloan-Kettering Cancer Center 1275 York Avenue New York, New York 10021 Dr. Dominick Salvatore Professor and Director of Graduate Program Department~ of Economics Fordham .University Bronx, New York 10461 Dr. David E: Shaw Managing General Partner D.E, Shaw & CO.. 120 West 45th Street 39th Floor New York, New York 10036 • Mr. William C. Steere, Jr. President & CEO Pfizer, Inc. 235 East 42nd Street New York, New York 10017-5755 Dr. Shmuel - Winograd Director, mathematical Sciences Dept. T:I Watson Research Center P.O. Box 218 Yorktown Heights, New York 10598 (21).

Past Chairman Dr. Cyril M. Harris ~ , Charles Bachelor Professor Emeritus of Electrical Engineering Columbia University " New York, New York 10027 Honorary Life Governor Mr. William: T. Golden 40 Wall Street Room 421 New York, New York 10005 General Counsel Ex-Officio Mrs. Helen L. Kaplan Skadden, Arps, .Slate,. Meagher & Flora 919 Third Avenue New York, New York. 10022 Chief Executive Officer Ex-Officio Mr. Rodney W.. Nichols The New York Academy of Sciences 2 East 63rd Street• New York; New York 10021, Secretary Ex-Officio Ms. Svetlana Kostic-Stone The New York Academy of Sciences 2 East 63rd Street New York, New York 10021: (22)

Salaries Conference Director Development Manger Conference Coordinator Administrative Assistant Promotion Coordinator Pro j ect .Budget~ 1,800.00 1,260.00 5,880.00 2,275.00 1,767..00 Benefits (31%) Conference Expense Conference Promotion Typesetting-and Printing-~ Postage and Shipping. Conference Materials Conference Facility Rental AV Technician/Audio~Taping. Receptionist Speakers'~ Food Function Reproduction Expenses 6,000.00 2,200.00 2,500.00 1,000.00 3,000~00 3,000.00 1,000.00 1,000.00 400.00 Travel. Staff Travel $ 3,000.00 Domestic Speakers' Travel $~ 4,500.00' Foreign. Speaker's Travel $ 10,000.00 Speakers'. Per Diem(sls0.00/n±~t~-~)$ 8,100.00 .Supplemental Support: Junior~Faculty.2X500 ~ $ ~ 1,000.00 Graduate Students 2X500 $ 1,000~00 Minority Attenders 2X500 $- 1,000.00' Publications Annals Academy Expense (12%) Rent Utilities Telephone Fax General Administration SUB-TOTAL TOTAL. Conference Sources of Support SmithKline Beecham Bristol Mayer~ Squibb ~3) $ 12,.982.00 $ 4,024.00 $ 20,.i00.00 $~28,600..00 .$ 18,000..00 $.83,706,00 $ 10,045.00 $ 1,50.0.00 $ 2,000.00