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University of Wisconsin Medical School Milwaukee Clinical Campus Department, of ~Medicine ~ PETER I. LELKES, Ph.D. Ass0~ate Professor Director. Laboratory Of Cell BiOlo~, (414) 285-7651 August 24~ 1992 Dr. Arthur D. :Eisenberg Associate Research Director. The Council for Tobacco Research USA,. inc. 900 Third Avenue New York, NY 10022 • (414) 283-7753 FAX (414).283-7874 RE: Subgroup Specialty Symposium on :?Endothelial CellHeterogeneity .and Organspecificity', at the Annual Meeting of the;Ameriean Society for .CellBiology,~Denver, CO, .November :15-19, t992 Dear Dr. Eisenberg: As you may be aware, ASCB has invited me to Organize the second annual.subgroup Specialty symposium on "Endothelial Cell Heterogeneity and Organspecificity" which will take place on Sunday, November 15, 1992 prior to the annual meetings of the American Society for Cell Biology. This meeting .is the follow-up of last year's.succ.essful meeting under .the same title which was made possible in part by the generous, support from industrial sources and which was attend by more that 250 people. The topic of this symposium is important and timely since many aspects of "Endothelial; Cell Biology" have become the focus of today's basic and applied research in cellular biology. For your~information, J ihave enclosed a list of•invited speakers-to this symposium.: ~ The issue of endothelial cell heterogeneity and organspecificity is of particular interest to pharmaceutical and biotechnology companies because of the many potential clinical applications, be it passivation of blood contacting surfaces, seeding of vascular, grafts, specific targeting Of drugs for accurate pharmacological interventions, gene-therapy, etc. I am aware of your company's interest in endothelial cell research andwould like to invite representatives of your company topa~t, icipate in the symposium. I would behappy to discuss with you the possibility of.having a distinguished scientist of your company present some aspects of your work which relates to endothelial cell heterogeneity and organspecificity at this symposium. To make this symposium possible I would specifically like to ask you for your generous Support to help defray some of the expenses. The ASCB sponsors these subgroup symposia, but does not contribute in any way to the costs for bringing t0gether an excellent rostrum of speakers. As a matter of fact, in addition to covering the costs for the .speakers, this year we will also have to pay for all the facilities. ~Th.er..efo_re, your corpo.rat~s very much ~needed and .appreciated in these times of tightening biadgets. As a ~ible~come of this meeting, I will assemble a booklet of abstracts and encourage the speakers to publish their presentations in the new journal "Endothelium". ~$1NAI SAMARITAN MEDiC.AL CENTER -:SINAI CAMPUS * 950 NORTH TWELb'TH ST. *,.P~O. BOX ~42 • MILWAUKEE. ~W155201-0342

August 24, 1992 Page two I would be grateful if you support thissymposium. Please make ~Jut ~a eheekko the "University of. ~ Wisconsin Medical School, -,Milwaukee Clinical Campus;:.Depax-tment O, LMedicine, Laboratory of Cell iBiology", earmarked for the ASCB Symposium. Thankyou in advance for your generous contribution. I am looking forward to hearing, from you soon. Sincerely, Associate Professor = " , Director, Laboratory of Cell Biology PIL/dmr. Encl.