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TI3E COUNCIL FOR TOBACCO RESEARCI3'-U. S.A. August 7, 1970 ! ® No. 766 Richard A. Lerner, M.D. Scripps Clinic and Research Foundation La Jolla, Calif. MEMORAIIIDUM : TO: The project committee comprising Dr. Huebner, Chm., Dr. Andervont, Dr. Sommers, and Dr. Jacobson. (Dr. Loosli and Dr. Little). FROM: John H. Kreisher SUBJECT: Site visit to Dr. Richard A. Lerner, M.D. A site visit was made to Dr. Lerner's laboratory on July 15, 1970. Dr. Lerner is a very bright young investigator working under Dr. Frank James Dixon. The laboratory facilities were excellent. Severa]l of the research approaches have been modified to reflect new findings by David Baltimore and Howard Teminiin the field of R N A virus transmission. The host control mechanism of viral genome expression is still central to the research program, although the experimental approach has been adapted to reflect this new information. The immediate target of the project is to find the location on the chromosome of the R N A viral genome using cells in synchronized growth. This work compliments that of Dr. Hans Meier at Jackson Laboratories. It would seem advantageous at this time for Dr. Lerner to visit the laboratories of Dr. Robert Huebner, Dr. George Todaroaand Dr. Ray Gilden, all located at the National Institute of Health and F.L.O.W. Laboratories in Bethesda, Md. Later in the fall, Dr. Lerner will have a post doctoral fellow working on our grant program exclusively. Dr. Lerner requested that the fellow be allowed to stop off at the laboratory of Dr. Ray Brittain at the Carnegie Institute in Washington, D. C. and to further inform himself of the techniques involved in nucleic acid hybridization. I have requested a letter covering both requests for submission to the Scientific Advisory Board for the September meeting. Also, in order to further coordinate Dr. Lerner's program with other similar research now supported by the CTR, we ahould have small meetings of the related groups and appropriate outside consultants in order to expedite the research and assure the optimal results. JHK:is 0