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VETERANS ADiVIINISTRATt®N HosPITAL, 130 WEST KINGSBRIDGE ROAD BRONx 68, NEw YORK April 16~ 1963 YOUR FILE REFERENCE: IN REPLY REFER TO:7o8lf 112 Dr.+Robert C,: Hockett Assoc: 'Scien.tific Director Tobacco Industry Research Committee 150 E, 42nd Street '' New York 17, New York Dear Bob: I'ju'st returned from a visit to Houston where I attended Cancer Chemotherapy and the Aimericari Associationi of , Thoracic Surgery meetings. While ther.e, I spent -soine time witYi'John 'Trentin at Bayl©r University Medical School. He -4as the one who_was able to induce malignant tumors in the chest cavity of newborh fiamsters by inj*ect,ing adenovirus 12. I reviewed his work care- fuYly with hs.m,'and as a result have some additional ideas-for our investigs.tive work. It appears obv3.ous to me that we are in a better position using'an influenza virus, such as PR-8, or the vaccina virus in lung studies for they are more likely to produce epithelial changes, whereas the'adenovirus 12, so far seems to be inducing malignant connective tissue tunors. Maria Duran Reynals is to use the vaccina to induce pulm'onary 1:esions.' 'The' animals will subsequently be exposed'to gases.. Dr. Goldring, meanwhile„ will combine`the work with the influenti:a, virus.. This combinat3:ori wi1.3l be very helpful. ' I'have 'definite'pYans - now' f or larger exposure chambers, and will follow through on their fabrication. Next week I airi going Jin for some- surgei-y at'Mt, Sinai 1ospital., but expect" to be out -3.n* about eight to.ten days~.-_so-I- should be availabe for discussa.on purposes in that time, and will return to full work in three to four weeks. I greatly appreciate tYie support 'you had given 'us -for the- "siapplemental grant. I exxpect'that -we`wi1.l'Yiave soine success with our other grarit r~equests. We expect site visits fr-om.-the N. Io H...and_ A, C. S, within the next month, Warm regards. Sincerely yours., ?HrLIp- COOPER - M.-ri__ .. . _.,_ Chief, Surgical Service Show veteran's full name and VA file number on all correspondence. If VA number is unknown, show service number.