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New sulphony[urea drug helps treat diabetics 4 A new sulphon}•lurea compound, glibenclarnide, is effective in the treatment of diabetic patients, ac- cording to the reports of a study described in the British lblcdical I oirrnal. In the test 9 men and 23 women who had suffered from diabetes for periods ranging fronT 1 to 16 vears were chosen as participants, Dr. 1. Anderson, who headed a research team at King's College Hospital Jledical School. London, reported. Dr. Anderson said that the 32 patients included in the study all presented difficulties in treatment. Four of the patients had been trans- ferred from insulin therapy and 2 of these were not well controlled during the study. Five of the pa- tients were given biguanide in ad- dition to high doses of another sulphon-•lurea before the study be- gan-and in the last 3 months of the trial were given biguanide in addition to glibenclamide. Thirteen of the subjects had a blood glucose level of 250 mg per 100 nil at the beginning of the trial. The normal level is 80 mg to 120 mg per 100 tnl. After the tests started, the pa- tients were seen monthly, so that the dosage of glibenclamide could be adjusted to fit individual needs. The dose ranged from 2.5 mg to 3; mg daily. Results: At the initiation of ther- apy, according to Dr. Anderson there was only one patient with a blood glucose concentration less than 130 mg per 100 ml. At the end of a 6 month period. 6 patients fell into this category. At the end of I year there were 7 such patients. Dr. Anderson noted that dosages of 35 mg daily produced no signifi- cant improvement over dosages of 15 mg daily. Second study: In the other stud,,., a team of researchers, led bv Dr. S. K. Bhatia of the Royal Victoria Hospital, Belfast, found that the h.•poglvcemic potency of ~ mg of glibenclamide corresponcL, to ab,,ut 1500 mg tolbutamicle or 37; mf: chlorpropamide. During the sturh, 2x patient, were treated for periods ul, to I year. The group included patient~ who had previously been maintained on diet alone, tolbutamicle. chlc,r- propamide, tolazamicle, or metfor- min. Rubella vaccine proves safe Transient arthralgia or arthritis seem to be the only side effect~, as- sociated with the German measle; vaccine, according to the \ ational Communicable Disease Center. The vaccine has been given to about 13 million Americans. WE OFFER MUCH MORE THAN LIP SERIIICE PROFIT, FOR EXAMPLE! 11 1 Compare Chap-et lip balm profit with what other lip balms promise you...there's a lot more in it for you when you sell Chap-et. For details and cooperative advertising programs, write Stanback Co., Ltd., Salisbury, N. C. 28144. AMERICAN DRUGGIST • September 7, 1970 . 1;, I I' i l d ` 6ca! Sc ence • 51 Phormoceui~co & Mrd