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) h, mo ogy; he has published more than 400 scientific paW pors; he has received ,nur,txorµ aus honors from American iotaal medical or- d un3vers1 music ranging piano etudes to choral sym- phornios, He was married to the late Mary Whipple Bztag for 52 years and recently marked his 81st birthday. All these numbers, of course, do not even begin to tell the story of Da, Bing, his life and his work, Leaping fromm highlight to highlight will have to suffice for the purposes of this nowslotter. HMR1 Executive Director William Opel said of Dr. :R9chardJ. I3ing, M.D., has been Dxrector of Experimental Cardi- ology at Huntington Medical. Researeh Institutes since 1969. Bing, "He appreciates bear.xtiful patterns, whether he finds them i:o nature, music or human relationships. Beyond his dedica- ticann to facts and the scientific method, he has a special ability for lifting the human spir9t," Recently, in his memento-filled office, Dr. Bing, relaxed and affable in his immac- ulate white coat, talked about what tie deemed to be his most important contri- butions to cardiology and other highlights of his lifo. Working at j 1940s vwith I7rs. Taussig, who were famous for their in.no- e"blue baby" operations, he helped S forms of congenital heart catheterization of the heart ch.atnbcrs, One of these which they first described was nartied Taussig-Bing clisµ oase, He and his team of researchers could see on the fluoroscope where the prob- lems were, "I think we were one of the first laboratories at the time to do this," he said. Most of his patients were blue-lipped babies and young children who were unµ able to get onougkah oxygen into their sys- tems due to the heart defects they were born wlth, One day, while directing the catheter - a narrow rubber tube --- from a vein in a patient's arm into t accidentally slip into the coronary sinu the large vein that drains the heart muscle, The blood sample he collected was very continued on page fe+ur said C, Hunte HMRI's Neurosu "Many stroke patients become so emo- tionally disturbed and so mentally de- pressed by their i.nability to perform the most basic tasks, as well as their burden onn the family, that they entertain suicidal icloas, C, Hunter Shelden, M.D., director of HM1't.t's stroke research program, studies iznages for in- dications tkxa.t a stroke has occurred. "Billions of dollars are spent annually to care for these patients," he trontinuod, "It is time for a more Izx-dopth analysis of stroke wztbh the hope that disability can be greatly reduced or possibly even olimi- nated," continued ars pszgv seven

, . and Stroke, National Institutes of Health, and the diroctionn of Douglas B. McCreery, F'h,D., is developing a new method of re- storing hearing In deaf persons. Also col- laborating on the research is the House Ear Institute (HET) in Los Angeles, Called an auditory prosthesis, the de- vice functions by encoding sounds picked up by a microphone into electrical signals that are then conveyed to an array of elec- trodes Implanted in the brain. Electrode fabaraicator.A.L Tirado tests the ira•suia- tion of an etectrocle to be used in experimental treatment of profound deafness in a joint HMItt project with the House Ear Tnstitute, The HMRI group, which also experimental pathologist Ted Yuen, Ph.D., and electrode fabricator Al Tirado, has been developing parameters for safe stim- ulation of microelectrodes to be im- planted In the tarain's cochlear nucleus, It is impottarlt to determine the maximum tration of electrode, and the duratioran of stimui that nerve cells will tolerate. William iM•. Agnew, Ph.D., is director of the Neurolog- ical Research Labo:ratories, "Nerve cells are not particularly tolerant to overstimulation," Dr. McCreery said. "It's like exercise - if you work out too often or benchh press too heavy a•woight, it will wear you down and perhaps dam- age your mttscles. We need safe protocols; these electrodes should work for many yoars," At HEI, progress has also been made. Researchers have found, by examining the cochlear nerve cells of cadavers of people who had been deaf for many years, that there are still viable nerve cells left to stimulate, Long-term deafness has not re- sulted In their total deterioratiota. © N, El hosted by Cathy Andrews and Maureen Savage. During the recep- Ilows Temple, guests crossed the street for a tour of HMRI's tis- otherapy, cqtogenctics and prostate cancer research laboratories at 99 Providing ann overview of the clinical aspects of prostate cancer was Dr. Lawrence •W. Jones, who told the audience that 50 percent of men over the age of 80 have prostate cancer, the second leading cause of cancer deaths of men in the United States and in the Pasadena area. "Digital rectal examination has proven through the years to be the most successful method of diagnosing prostate cancer," he said, "with ultrascrttnd agood sup- portive tool in conjunction with prostatic needle biopsy." Most prostate cancer is latent, that is, it is present but apparontly dormant, It is discov- ered often by chance, when another genito-urinary prolalo:mm is being treated, or else at autopsy. Latent prostate cancer causes no problems; clinical prostate cancer does, Repressing prostate cancer ~ David Kirk, Ph.D., a HMRI cell biologist, has been at work to isolate and identify sub- stances from normal human tissue that could perhaps repress clinical prostate cancer. It is possible,ho said, that these same substances are present inn latent prostate cancer, pre- venting it from growing. "Any future breakthrough in the control and understanding of clinical prostate cancer will probably involve the ide.ntification and purification of normal growth inhibitors from normal prostate tissue," he said. HMRI's Magnetic Resonance Spectroscopy (MRS) program under the direction of Brian D. Ross, M.D., D. Phil., is developing new methods for early diagnosis of the disease, its metabolic identification and characterization, its chemical "fingerprints" in preclinical and precancerous conditions, and. MRS monitoring of patients' treatment. Franlc Parivar, M.D., of HMRI's Magnetic Resonance 1ab has been working on the prcts- tate 3magio.g program for two years. For this imaging a coil is inserted into the rectun:am and provides a,txa.uch better view of the prostate than conventional MRI proced,ures, The ex- aminatiotx ta.kes abc,ut 45 minutes, HMRC is one of four centers in the U.S., and the only one on the West Coast, to test the coil for FDA approval, which has now been given. Also participating In this effort are Dr. Ross,lJr. Jones, who has referred research patients, and Vas i^tajanayaga:m, Ph.D., who de- veloped the necessary pulse sequences for MR imaging of the prostate, Patients are referred by their physicians to i;7r. Parivar at (818) 397-8532, D izag at the Odd Fellows Te:mtale, Guild HMRL dvances in HMRI's prostate cancer research program were presented for Al- Guild members and their husbands at the Guild's November 2:meetiang, The ii drews welcome HMit.T scientists Frank Parivar, M.t7., and

ry M. netic resonance programs and prostate cancer research. "Prostate cancer is so widespread that I'm greatly interested in its detection, prevention, control and cure," he said, Mr, Harrington has been a member of the Board's investment committee for eight years. "f attempt to make observa- tions that may point out over-evaluation in the portfolio," he said. Jerry Harrington grew up in the Pasa- dena area and lived here for many years. He earned business administration and fi- nance degrees from UCLA, then became an officer in the CJ.S. Navy, I-Ie worked for Coldwell Banker, the real estate firm, in property management and in 1959 joined E. F.1-lutton. as a stockbroker and financial consultant. Today his offices are at Shear- son, Lehman, Hutton in Newport Beach. Mr. Harrington has two daughters in their m.id-twenties, His main avocation is traveling to faraway, little-known places; he tries to visit the:r.tam during times of festi- vals and special events, usually accotnpa- nied by hi returned from Tibet an western China. He has taken trips to Ant- arctica and cruised to remote islands such as St, Helena and Pitcairn Island. He sailed for a month from Chile to 'awa.hiti, after cruising the Chilean fjords. "I'm always looking for something a bit different when I travel," Mr, Harrington said. in 1974, he went around the world in five weeks, visiting Iran, Afghanistan, Ceylon, Nepal, Burma, Laos, Vietnam. He's had the good fortune to travel to Cambodia, Lebanon and Kuwait when they were still safe to visit. He speaks "semi-fluent" Spanish, a bit of German and French, and has studied Japanese and Russian in preparation for his trips to those countries. "The words 'where is' are very important in every country," he added. When not managing portfolios or trav- eling, he skis, plays tennis and golf. Roberts Awarded Nation ohn D. Roberts, f'h.D., treasurer of HMRI's Board of Directors and Jtitute Professor of Chem- istry, Emeritus, at Caltech, has received the National Medal of Science, the na- tion's highest honor in sci- ence, In a ceremony at the White House on November 13, President Bush pre- sented Dr.l2oberts and 20 other scientists with their medals. « ceive the hon Roberts. "It was a nice sion. President and Mrs. Bush were very gracious." Dr. Roberts is noted for his studies of magnetic reso- nance spectroscopy and re- action mechanisms in John D. Roberts, Ph.l)., received the National Medal of Science, the nation's highest honor in science, from President George F3ushh in a White House ceremony November 13, 1990, corganic chemistry. Also a member of the National Academy of Science, he chairs HMRI's Magnetic Resonance Research Committee. Past recipients of the National Medal of Science include Nobel Prize winners Linus Pauling, Richard Feynman, g. J. Corey; William Hewlett, a founder of Hewlett-Packard; Paul Lauterbur and Edward Purcell, pioneers in MR imaging; and industrialist-philanthro- pist Arnold Becltrnan,C1 harp, M.D., one of nd William Opel, 1-1M1t,C Board member Jerry 141.Harriragton As for the future of HMRI, Mr, Har- rington hopes that "more measures to ef- fect cures for various types of cancer can be found. I think we're doing a good job. Bill Opel knows just where plans and en- eraies should be directed." 0 Liver and Braa~. esearchers in HMF21's Magnetic Res- onance onance Spectroscopy Laboratory are refining the technique of nitro- gen ('IN) spectroscopy to study how liver disease can affect brain function. According to laboratory director Dr. Brian Ross, recent studies indicate that 80% of patients with cirrhosis of the liver may be unfit to drive a car due to the in- terference of their disease with brain func- tion, Another disease, hepatic encephalopathy, is a disturbance of brain rrr.etabolisrnm that occurs when alcoholism disrupts liver function; it is also seen in patients after severe viral hepatitis. Keiko Kanamori, Ph.D., explains that in cases of hepatic encephalopathy the waste product ammonia cannot be removed by the liver and is carried in the bloodstream to the brain, where it diffuses and acts as a toxin, causing disturbances of brain me- tabolism. "Through 'sN spectroscopy," she 1'"we can also detect the incorpora- ia into glutamine - which pathway by w xified in the brain - and even GABA, an important neurotransmitter." "Dr. Kanamori has improved the method of "N 100-fold," said Dr. Ross, "by observing the protons attached to ni- trogen." He hopes the research will lead to a treatment for metabolic abnormalities which result from common liver diseases, thereby preventing the onset of brain complications. 0

MMRI news Ac } 1lwlltt he izarradix&d high-speeci'cine , _. ~tngtdph`y' vievv the cantrn~~e~t r,o>r~.~ , g„1:E ` ~s a way to, mierc~ ~t.aa,~.ul itian,af the heax>y., , _._ ..M.M~ ,.: ...w... ....... ,.,,. dark, mearai6t; it l,rckcd n,;,ygen. 'T"his had- Arid'nciw he is working on the role of ,hs.ppun~,.~th pchc, t e arrhers,$~~~ ~., t~~~rt~lqt~ielial cells which line.the blood wthe ~vould°'trst l,tiki t hc tr.~k,c t, t~k ~et~t~y ~~resse~s i] k~es~ eelis prcrduce :rnany .sul~4 - ~' s.zxd aim for the hc_arl c laailabc [ taun wath stattees, sazra.e of which prevent Clot;tic~:,~, . •. ati~aat. ~. ~ ~ ~ 4z~C~.kt~ri7~tF tl~ofsttr.>,,un~l3nt -~ p t ~iYt~~ia, a ili~~d'tka;at<•} 'l, ad irc,t ~:,- ~rraiiscl C~1l.S t'~gul ttiti~.;1S1t~Crd ~c~ssc~i=~ da. lecteci blooi'd wkiich the laeact musclh h.rd ~diuneter, others that relax the s,rteries. He _ ~.,,,„ us~d fcsr xt~xai~,n rtr~urisklrrAet,i i rrd ~;a~~ rn .~:~i~, l~~ttic'~~::r~~*'intetest6d~an th~substatiees ~tapprartur9ity'Wafiginai r~ itcch'c;ra "~" fl'itlt"wla: live.pati6cats_;ts .tc?..,vuhi0xzwIr>M..~ts uack kcraw vmucsYa o'~~tti'~dm~th-e.t%~~~~i ei~~:d aaa 'd ~~iaus~diae aesea~ch~.rs ~i~ue. d~e::~~ ~ : h cazn ..~, .pa.ufu ... ,v. ds it dis~~rd~d"as ~raste. ent ide4s as,~.,..~.t.,ra cvh~t canstitut~s 1 I~li~. ~c5t5trd`tk, lu :ir r rta~ tn.iJqt c~l the, =Scattac t'tiital, it cc~n.tainsrn~itric ~ ~p.... ~ eXx~faum ~h I,I: r,tf "'h~sa~d•~aka4xlt k~ts':~~7r`.~~at~g-laeaiev~s that,:lyscaletilkaan~-a-~ilic:,s "~"That w;c; rff c c,v, ycru see lt was ~•phplipid in the traezrlbrane of those cc=lls, ~.... ~ StiC f lt~li _:.5rl~k~ i 4,~,rgc t711~ Yirn~ ~ ,~; 'rl]~Y~UP~ I~E:}; to t11c reI N~~7~tier•iif C;ardr.ic:°Gw~~~alSalisSrr ~ Llucacl":(-,sseis: l~Titrtc rr~x,.de is,l:;t,uiluktc:d l,y r tb n e t<ca 1-tas ~> ~a~l~s. tncl ~ w anitsc,k=ly~er~u,..v~rhtcla l~ss been.,used sir, e ., ~~18QC~storelte tiac,mtascle~ttaic aol,~l,c stardacd tk,,netaix,lasn) c i thr c c,nstriclw the heart's bir -k v( fsels and - i. _.,~ _. . ... ~~ ' - Stita.litrr)d_ te;rls.I ,f i,. 7gi11~~17eCtt,~:Cic'"Tt ~ 1 nt•,~~ta=thatNU ci'~,c Ire (y<°at !c ,.. ~ itetthc sli;~;ii ,tzth,~aii~k iliii~~i iln..~. ,di~tlt ;x~ater prcauctn ca uxaac ,rars rnees .. . ~ r h~t~ iilate cli~~slba2~~ c 5~ l5 "t;uc kr se1E-` egulation caf the circulatiora is v'e.ry beauti- I I rt1 hut yc,tre;etwthat~frotn'i1T~.-wisdom c>f tl4`body,'- "i six,~xn:,~ "ai"d 5~5~rtarpc,se= . ' :.r.• ~ .fr.itl} ind beauti:t51~ drrne." kab r5 i~y~~~~n i f iL.owt~ ~t~ a:d,tkaelial c~lI`s or :~rier n~.arch by s,t~ tac.hrpgthetM:„tr~-plnstt~bc trl„sc?xhat the.) ' st,ck~ii tlae tts?~~c~~~ll,~.r_I cp~t, cells and beads s~e bad~,ea f, cl, x Plcawin~ .~ ki; r f rr I hystalogic~ iictcacheliat c :nnet:,.tiotrtla< t',clinit`lueS st Y1 a'O;C.tI.atC1g:Ca il rt se as to: p I rt a Ia. 1 i ~a> t'~'Sti2lg+CrldCltl,e'Gal re1V3 to titwciy_ [hcir r f feia; un i~roiiar y ar TvS.T7.,aallAl,djxtldria C)rmtc; (qfficliiig,~lliarra I.orclc^rr, 1)r: Fiirieh pa'caduced. ~ .,n,1lvzecl, «r liai~ori i,.a»^rwe6 and l;altech's Mi- ~I)r`_lircil perfrrrznsia dr.is,n,,sii Ci~~~t ,)n r hluc.-.; :baby" wlrile at l'd LIITTopl.inti ITo,l,ital in i9J"„ Bing t willv,. at7 salcaeieta.ft(7 i i, IriU7 •a At an early age, M ,Oon lraund"tlrar_his~-i _ irt cr,riap, rn > tka,uj,ta,:,ight readi j laVin4; pt~c e°I , tl u_,i< n.ei ~ },r udown foz liit n a nd tra r11 rotas Cr ~-ptataists to pll•y..11< wr~~t~ k,i~'fir~t oxis,,st age six"~c ~cral or hr I~i:~r~ co.txapCa- •--:>itiorts, iu,cludinl; his Missa, a cello sonata, ~,tcrc,s`"Old ~ti kn~:_ikta.utets *ha~~~ee~i played ancl [;c cc~rt~e~tli,r~rCrssiiarlall~-~~ftvv have ti6hof EIJ,ltl' is cau5t`d h}-.~~r~' k,cr~n,pulrlrstaf~il.r k,lat;ie~,1 f(i1;t~e of b1.Ca,<7rk flova• t,llecl "5laear Izi }1igk1 school, stress." The greater the flow cal blood - gh constricted blood wessels,- t ita;'graod`Fae rnia, hypertensiuia Yhc ~.,.rt . t r~ridtsi~ ~ti%d, wa.zinuc, ri,rins disease:^s work're~traaed hirra t "Father of Cardtac Metabolism among cRTitrh anc_- ~ ~a i,yiaet`tkay- c ekks ` ~., n

HMR1 news 1 , w]ri i i tt 5 z i lu B t , k 2 t)r Itcl~tl latts ~} 1,ui~ci„ ~il t;c~irlu[r cazz~iolc,i},' zr~d~~~ a~aitla<rtfivv%t~a1)>. tit„t;aili,c il,i,~Iazu~ ~tc~ui~< c~rlFtcis~rtf ar'clecs7~ CP~+";~ltl. 196& ~;t)getheC, they f I rst d< tic t Ihe•d tlit c ortz c xtttal l;lea.t.'t _. =:.~.,,;,...~...~ n, ~ .r ~,I u, In(ic to tki< <I~~tn"1~ ~I ~ine~iai c~I`i~il~la :al w ;ltluiia;;; ~y~~ tt~w,iilt ~ ui, I'• ril, -rl l,il~~si,l II ~ h~ ~i,ral l~ i.ic~l`~.an„~ iL~rI.U ~~lin~;~it I>lcl]15,3U1~1 11 r. I Il i . r ~ tz-eil;: I'I e t on t I history of cardictlcagyWlaa aretthe - ~Iiial> t CClntrir>11tpI'S tC1.th-1' C.'-fielCl? b»t. tttivG: [>urittg the Renaissance, Vesa- _/im. ~ I, ~,cr4bec1 thombiood ve45t-is7r,f the' ~= p . lt]g th6ta:-futir,:kiC+ri. tt(:;,a vicliaut ktauw inci made beautiful draw- rtinaityc.irculattc7ri Ili t"~"~al~espeares t;ti1e) de- ia6c+ln` vexvtliit~,~ zt75Gi iz t~latii'tay ss w~a~sirkacle until the 19thh and ics: Thcrt tnan.y~sciernti5mop`w=.` a lwof advanct s~~A~cre zna;dOy with the discovcty af nitara- w~l~~ri~i;;tl~e el~~t>ocardia~tam, ~t< _ ..._ ,..,....~. ....,. ~...,. w . __.. . _... 'mC}Te""fc;cc'I,ltly" -catl'l`6teI`iZitibffg11C{ t chia- ~1 -dy aac ~S_W °rn zt~ id~.. IltniiaUeslrClpri.pht il <i : Clz., u.try -;"W71A1 A,itE "YC1T~V.~EW~ C1N~ :n1ca01".a<iiv C 1oat,0c.W~,t..;: ~ NYrcll, I think It's gDtng crcat f;tin> clina- i:i"t;'rtky vit:'p5i:is Cluat s 4 t c at. ie tl is ;. I t,rr~c pid~miialza,g~ _ tb tt ,~~~, tatia „, y Ir~ ;f li,t tjCb[u 1n tnit<t,l tsarlt7-. ni le•tc't1x i;11T17j~,118 C~11~"iti~~tlli:,iri • pr-`- d, , tl, r„;,r~rtificat~~~aicl~tzri fc i;lc . l sluc9zc ~, e is personal lifc: ; ; Ycaix"a:re f1nishin%t a boo cerpt nt A i e + 5 I~1k. tissue cultrare lai,'„:I I, tt al ItS,titntr'itl'G ,e_ , , aaClcrvd t~ tliC: I iitlLt'rt'. tklc nd ~;ttJ1e"ka tuch t~r~l>c[ P,r'i>cA , "~ er AI,:-:(':~~ Ic I. wla~u "W'dSiaX'lpt, ~',rrl II young ~rld l~"lt' 11 bt, :in,";i iil(iii iii ili, ~T"5,~:Fiiti~~llc cli~ iw:re ktr° ~ttlt~ir~ l illc cli~, t_, ?1~ciat rtta ~~i ircl fiofn tla< 4rmi lietitclaanr I-nlr,rrcl+ attr.l cluritj,i~ iIl •,vo~k w illz 1'au ~::.~ucl lil t1~i.Ck; 1'~~ visiteci Germany bricfly under t1 j, .zutil>ice5 (,C iI jk in Fraakft,txt to tC".rizatiC7L1.C1:CYa yC11Ll,tii thc :illut, r iiu I-,!d ;i I>UIlCf Ialat ,2 ~ ~~ had lpdgedItt tlir: Ii,,ltt vc^tlttiClI _ ..1'nlr,.ii~ i_Ilir l_~,~,~~ somewhat cciri6 ~I I Ic i hc ~t:;~.11z1; " Over the y(%l ls, l i,:' 1, i a. Cf tL] tl'It ~c l.l , l kl l g,t7 a!.I ~,Ci! I i I Ili j', J-1e1ptW,`d i1C1"t~~E",~I Iili:lilV CdCcllplO V;pIO~",PZ1111.:1i1, i ltaltl~l~ C~C/~~T1Sc rtsnt ~.~rs9inltzz;ists in his t;thc,t-air>t y, llc has been YIIIU~• l1y(ict,'I71at1y 1IIllUd7ilfl,=tll~ IUf;111 - of Iitt~, Fc•clt'r;tlMRci,iilbiiI :1't•t>'f'c: sscrr~-Scac: atist ;aCtcl° I~c"ltlini, irtll,r,rtaztt-aclznini4b ltivc l5c,st's W1'tile continuing his catz;di.tc rrse.it(JIat various tnwdical schuc,is Eic,:ros the country, he~canic taHtttttiut;totl Mhnzorlai llospital and ical Kcscarc_l,;atad r;tart tlac: l.tcaspit tl's inte:rraa ]~l,e~l1acl t,.>~rc"t~7ruit cach~resi rrt'ancl frc,m ttusC7it;tis.that'tod itc, l1t~stryCar, the ~~rc.uF~•raxrz~~kza5 i

HM,RM news are important, but you have to take some of these statistics wit I think great advanc by cliruciatas; i""or example, occlusion of coronary blood vessels (heart attack) was not recagrxized until Herrick described it in 1912, wh.ich got tion. Modern c ardi all 1aiolcagieal°sciences -M- trtr.7fe.cula,r bical- cagy. "i"hey"ve°stlready cloned the gene re- spansible frir,.~amitial h.yp&t:rophy:(')1 the .," heart, whicli;cint lead t+a"'s~clcieta d~;ttlt ir~: `; athletes, f~r~ jnstance. '~~j~ _the dir,c cri90. of modern science. . [ Et W'OULD YCiLT LIKE TO ANCIT'HEH. -DIRECTION;': I+Ia. We will always g6'ix;~ shawnn by the advances In physic istry and blrii0~y.'We an~~t~ticr~ 1(~ l ~ 11 L 1 y Well, x.met Mary when I was an intern musician I've ever znet wl Ctilutrtbia-~'reslayteriat~, and she wa~ a µtc, ta~j "zr~x~sic: Cither,crrrrsit chniciart.. I think we Rc,t ttiaz'ried `with'in:F""vcau clte"time of dav; '1'ix6 ree.:ar four .trtcanths.r:rf stpCltlwt7 at the momen irxtportat'tt t 1 e ii tr ave so throug A s been.a;,..„,.„ _or..srr.,occupied with.then ~„ Cp ~tt~wttu~r with tha, ari was at them from very early chi by tkteiri: iehli ways s At home m~."ah J.uts'latt: w1f.',: ~.?i one of his original compositions. not always "lea ding. ~ = "CVT-iAT ARE 'I"HE HIGH w''t"1TN'I" 5"5 YOUR CA REER? With Carrel uacl "1.it1c11>etr +.l i"<tc Otu.). An-i Ii( ~r lrfx~inf~1'l~ty ' ; rt intern in knew music, surgery. JM:rtct:n•:.t;ctca mucn,s77rgr:ry more inter ple, Mary"s father, was hrc.".+:d'>f sur there. And working cvitk, I (qrner Smi Hopkins was'aisa aa high iauin.t - there were such n.ic.e people of~t1-te same age_asw rzr.y wife and`L Our ehiidrera played tci- r gether. The old folks (age.') ~)ralsa.Were;` it to n.ur Priends, three kids. Bill, who is Birminghaz~,,,, Alabama '~ the medical,' _" dence at Caltech, is a ver schc~al -- also was a high point. It was my trumpeter, married to a ee11i favorite place to wc~rk..1 had a lab all to myself, under my own direction, and that's why I did the work on cardiac t~eµ tabpli.sm. And Alaban~.a is a lovely place. Northerners don't know it. A wonderful experien.cel th S17cs utid~ dif!icult.at bara, who studied voice at Music but switched to speech therapy. She's busy with her two kids now, WHAT ARE THE HIGHLIGHTS !t~.~ Y'UT I~t. LIFE WITH ~CECx.A..RJ TO "YQTJ1t2R ci atxr;ntir~nr_ n't'l~ivc ase- it's _ ,Ar7.at}~er high 5tan linga>f ' ,aiC ~Iay< d here a :, ontipares ~.vell_i~layr°d!. 1~()13B~' orxe hobby I liked nnnsc vras sl i;t~;;. It ;4as iliffe~;erYt, then, iri.tk~e "2C)s at~~i ',0,. A ! '~Vetaztd t~a"wallr", up d7.e'~1~.t~u~.t,titas, ~,rrr~ur ~ oArri ,slci~,,with sicins uraciex them to f?re-_ µ >kie:r ;w a boy. But then when T"~vas about 1.G,,:~~.vpt7,twta, the Tyr~rl:with a ;fricnds, ;~ril all of a si~~.~leus it c r>>tnfv,a .;afc.~~:kicr, es~at`^cially on tl~~° „la "Ct< is,~v~rkr<^[l~you hd<<~ ~;cwYlecrne e';sr• on :°r~~i~e: Yota lekrn hr~~.v Ici1>e C:rrta%1! tlic~.tr. 'OU..t1,e.VeJ=sChLlss p17 a ~;la(lt'r, Irla)'{,)tz p~...., .. . . ., , etia;ises are, i"tl-rirzi~:-rri+wlc climbin~,~G) the S~c,l~.;rraites`-_ ttASl s,!~'iin~;~"ti~rere prc~~?sil)ly my t~~ca4t t;taot-° - " , ce hobt ies, i~Sathi:ng_c:~~.ruld cr~t~,~± are t±are to ;hat." Notkii.t~g nc+thin.,~,-h. ~3'~>Er.~:r FA.CTa~.S PLA"X° A R (:oM1[NC~-A-SC7CCESSFC.TE SCIE: afraid;that cerrra.~,~te .n eer,~te.nee is t~aac. only f:rctt r. Getting along 'a,ith your scien- tt1iCt t-,lletif;nies :is q~`tlar=t=reat~5t itn~ ~tiru r :-Y_,u only succ.c.cci k.~eCauaet <,t } tr~renris,_ant>,_.yau fnail.k~ec;iuse of itirlifferet~t ie 1 w~.ic ; .,, . e a },1 t nd Ju ra_-your eneu at~.< 3N"I' •I°r~.YE:G~'" . Mla't~T~..`I AN `I' T~ wy'.'re of CQUrs~..; :ctect t~,ase trtlrags; even so, you cann lal~t~rr;ir thann knawin.gtl~e rrt , s•~,4rd as you can, and'i:F'y , that was ve'['V EN? and is wcjilcir~g vha al.mcist zrt.acle ed, now lias isician in Resi-. y , very busy t! ~ 0 i Musica these p for full performed in.1981. It is one of over 250 pieces composed by Dr, Eicag.

e ne iac e would drive a hardd bargain," said HM t was very able and was respected itt th son was tisqcciallv interested ixx HM1tT's work in cancer and n rraajor, ccrntributar, particularly in tim tdale cc,tatitiued. "He woulcl always cattxe through witbh an extr it 'W<aS r1eeC1e d." ' ire i , rteous. with a shar R< t m years, he caw . >>, 0 i e xecutive ;Ui:rectt7r, '~Mz". Swanson otten statecl ie long-term goal of conquering cancer. He was p withthe late 1 Biology LabciM ter, M atm .ueser ar- alpgical of need," 0 Feb- ing, s" theme cele- ght about by f7r. Bing, but also his acco Music will be furnished by Art Deco and His Society Orchestra, which is led by Vincent Houser and includ The reception begins at Benefit committee ;mem Bolenbaugh, Ginny Cushman, Sa Getzen, Carolyn Helsfacr, Connie Weston. For reservations and further information, please call Mary Ann (818) 397-5447.0 e carettnuerX fra»z page arte Strokes cann occur at any age but. usually affect persons in late-middle life and in- crease in frequency with age. Dr. Shelden has developed aprOject in collaboration with Huntington Memorial Hospital, a basic in-depth study of stroke at the molecular level. The term "stroke" suggests a process that is sudden iun ansct, vascular in character and intracranial in lo- aneurysm, brain tumor. His project re most common form of stro clude primary arte- red ociated with o the e, secondary Oxygen deprivation hcnn some tissue Is deprived of an a quateatnc,unt of oxygen. This catl result from the clogging of a small blood vessel by a clot or a piece of tissu,e that breaks off from a small roughened area (plaque) and disrupts the necessary flow of oxy- gen-carrying b10od. The area of the vascu- lar disruption can lead to severe local damage, while the rest of the brain is rela- tively unaffected. Symptoms vary depending upon the diameter of the clogged vessel and the area of its final distributicrn. Different areas of the brain control specific functions - e.g., speech, vision, ability to think. "It's a problcza.~ from which you may recover, but it's likely there will be some residual impairment of function," said Dr. Slaclden. "And also there is a possibillty of repeti- ticrnn of strokes iun the future." The project over the next two years is concerned with strokes caused by clog- ing of the arteries. 1Jr, just what ac- naturc t of a clot and restoration of normal ci tion. Usually the brain can't wait that lcrng.>, sels and what the obstru "We want to find how mucc ticu.t has from the time of onset of a stroke until irreversible brain changes have occurred," Dr. Shelden said. "We've tried to design a program to develop some cedures that would keep the affected cQ:ztznetcd on page eight 7

Stroke Project cc+ntlnued jroat page seven Perfusion, diffusion, diversion The two-year program encompasses three unique areas of research: 1) A study of "perfusion," the straight- forward movement through the blood vessels of fluid containing nutrients and oxygen. Dr. Shelden compares the prob- lems the brain has during stroke to the function of a lawn sprinkling system. Whenn the water is turned on and the pipe open, the grass stays gree.o. If turned' off, the grass becomes progressively less via- ble and turns brown.. If the water is turned on again, even after several days, the grass is still alive and recovers its green coloar. However, if the water is with- held for too long a time, the grass dies and no additional amount of water will be ef- fective. Brain tissue is rrt.uchh more sensiw tive, of course, but it follows a similar pattern. 2) "Diffusion," movement of the fluid at approximately 90 degrees out throughh the walls of the capillaries. This motion of fluµ icls and oxygen out through the capillary wall Into the intercellular space is under intense study, and it can now be visual- ized noninvasively by magnetic resonance spectroscopy (MRS). Diffusion is a slow- acting system but a valuable source of ox- ygen inn tissue at the lower boundary of viability. In the lawn sprinkler analogy, this might account for seepage of sub-surM face water that flowed down a side hill to the browran patch. Water from such-a source might even add another day or so of viability to the brown grass. 3) The temporary rerouting of the circu- lationn to the affected braira area. If oxyr gerrated blood cannot reach the stroke > be tried - i,e., aon arrr tory can be joined to a vein so that blood will pass into the capillaries in a reverse, direction and transport necessary oxygen and nutrients into the stroke area. In the grass model, it would be like forcing wa- .CviR techaiciann josh T:C,urutz displays a magnetic resonance hxtaging coil which he has designed for early detection of stroke. Other members of fT.MTtI"s stroke research team itzclude. (i to r) surgical nurse Gitsa Anhalt, surgery technician Stacy Pritt, neurosurgeons Charles Y. "Yeh,14T.D., and C. Hunter Shelden, M.D., program director. ter through a pipe that normally functions as a drainage outlet, MRS helps treatment With experimental MRS at HMRI, diag- nosis of a stroke caon frequently be con- firmed within one hour. As treatment is given, MRS can monitor brain chemistry ---• amino acids and acidity plus the hydro- gen atoms i;o the brain fluid. Brain func- tion an.d regulation of blood flow can also be checked on a noninvasive basis. Sev- eral stroke patients have already been monitored at HMRI's spectroscopy facility under the direction of Brian D. Ross, M,D,, D. Phil. "Treatment has to be started within the first hour," Dr, Sheidenn said, "That means the procedures must be simple, rton- traumatic and defi.nitive. You have to plan what you're going to do and then be able to do it. "Ve've spent a year developing a small, precise reproducible brain model that will allow analytical diagnostic procedures, plus a number of specific chemical treat- ment methods," he continued. Once a stroke occurs, a patient must be given oxygen, nutrients and chemicals by all available routes. In this way, viability of the affected brain area may be maintained until nature's own clot-dissolving method cann restore natural blood flow. HTvJ,R.I's stroke research is funded jointly by contributions from the James G. fios- vrell Foundation, the Braun Foundation, the Lucile H, and Mitchell B. Howe Foun- dation, the,)a.meson Foundation, the Hunw Trust and other donors. 0