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D. H AN1 1,~~ 0 N D LOS ANGELES COUNTY - UNIVERSITY OF SOUTHERN CALIFORNIA CANCER HOSPITAL. AND RESEARCH INSTITUTE AND REGIONAL CANCER PROGRAM CONTENTS PAGE SUMMARY 1 CANCER PLANNING COMMITTEE CURRENT _CANCER ACTIVITIES - USC FACULTIES BACKGROUND AND HISTORY ROLE OF THE LAC-USC CANCER CENTER SIGNIFICANT PROGRAM ACCOMPLISHMENTS SINCE 1971 DESCRIPTION OF THE PROPOSED FACILITY THE SELECTED SITE SPECIAL CHARACTERISTICS OF THE FACILITY 4 8 13 15 18 19 20 COST ESTIMATES 21 MAP OF MEDICAL CENTER - MEDICAL CAMPUS 24 PROPOSED CANCER HOSPITAL & RESEARCH INSTITUTE , 25 AERIAL VIEW OF MEDICAL CENTER - MEDICAL CAMPUS MODEL OF THE MASTER PLAN SITE PLAN LONGITUDINAL SECTION OF PROPOSED STRUCTURE TYPICAL FLOOR PLAN ,. November 1973 27 31 33 34 , 35 D. HAMMCIND

LOS ANGELES COUNTX - UNIVERSITY OF SOUTHERN CALIFORNIA CANCER CENTER SUMMARY An understanding between the County and the University was announced in December 1968 to jointly develop a regional cancer center by providing local funds to augment those anticipated from the Federal Government. A joint University=County Planning Committee, has worked to bring these plans to reality. During this period the National Cancer Act was passed which provided additional funds to the National Cancer Institute to develop a national plan for the conquest of cancer. Working closely with the National Cancer Institute (NCI), local planning has progressed rapidly during the past two years and has led to the following accomplishments : o Identification and coordination of the basic science and Medical Center faculty involved in cancer research, treatment and education at the University and the LAC-USC Medical Center. o Designation by the NCI of the LAC-USC Cancer Center as one of eight new Comprehensive Centers to be developed with assistance of NCI into a national network. o Award of a Cancer Center Grant for operational funding of advances in diagnosis, treatment and basic research. This totals $7.6 million for the first three years of the program. These programs will benefit thousands of cancer patients throughout the region. ® Award of $2 ,145,700 for renovation of three buildings at the California College of Medicine property and the Medical Center to develop beds for advanced cancer treatments and laboratories to develop new techniques for diagnosis and treatment. • Approval of a construction grant from the NCI in the amount of $11, 880, 000 to assist in financing the LAC-USC Cancer Hospital and Research Institute.

CANCER PIANNING COMMITTEE L.A. County, Chief Administrative Office William A. Leone Chief, Capital Projects Division L.A. County, Department of Health Services Liston A. Witherill Director John E. Affeldt, M.D. Medical Director David Odell Director of Planning (to August 1972) Donald Avant Deputy Director for Operations (from September 1972) L.A. County - USC Medical Center Leslie R. Smith Executive Director Aaron Lohr Acting Executive Director Robert E. Tranquada, M.D. Medical Director USC School of Medicine Dean Chairman, Department Chairman, Department Chairman, Department Chairman, Department Chairman, Department Chairman, Department Chairman, Department Chairman, Department Chairman, Department Chairman, Department Chairman, Department Chairman, Department Associate Dean, Basic Associate Dean of Medicine (to 9/6/72) of Medicine (from 9/7/72) of Obs. and Gyn. of Surgery of Pediatrics (LAC-USC) of Pediatrics (CHLA) of Pathology (to 8/31/72) of Pathology (from 9/1/72 ) of Community Medicine of Biochemistry of Pharmacology of Radiology Sciences Franz K. Bauer, M.D. Thomas Brem, M.D. John Bethune, M.D. Edwa rd J. Quilliga n, M. D. Leonard Rosoff, M.D. Paul F. Wehrle, M.D. George N. Donnell, M.D. Hugh Edmondson, M.D. Nancy Warner, M . D . Harold Mazur, M . D . Arnold F. Brodi e, Ph. D. Samuel Bessman, M.D. George Jacobson, M. D. Paul R. Saunders, Ph.D. Allen Mathies, M. D. USC School of Pharmacy John A. Biles, Ph.D. USC School of Dentistry John Ingle, D.D.S. William Crawford, D.D.S. Dean Dean (to October 1972) Acting Dean L:A. County - USC Cancer Center Denman Hammond, V.D. Director William J. weitekamp Administrator Thomas C. Hall, M.D. Associate Director for Clinical Investigation Robert J. Hasterlik, M.D. Associate Director for Regional Activities -2- C 4.

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CURRENT CANCER ACTIVITIES OF THE MEDICAL CENTER AND BASIC SCIENCE STAFF The cancer activities conducted by the Medical Center clinical staff and the TAC-USC basic science staff probably comprise the major cancer research and treatment effort in the West and one of the largest in the country, as illustrated by the following: • Clinical Care On an average day, Medical Center and basic science staff supervise the management of over 225 bed patients with cancer at the Medical Center, the John Wesley Hospital, and the Childrens Hospital of Los Angeles, • Clinical Investigation Formal studies of new and advanced diagnosis and treatment of cancer patients are in progress in almost all clinical departments of the USC School of Medicine and in the Schools of Dentistry and Pharmacy. LAC- USC faculty and staff members in various departments are participants in national studies of breast, renal, prostate, bladder and gynecologic cancer and in cancer radiation therapy. The Chairmen and Headquarters Office of two national cooperative groups conducting controlled clinical investigation of new treatments for cancer are located at the LAC-USC Medical Center and John Wesley Hospital. These are: the Childrens Cancer Study Group consisting of investigators of 23 major pediatric medical centers of the United States and Canada, and, the Western Cancer Study Group which includes the major university hospital and medical centers of the Pacific Coast. • Basic Research Approximately 90 USC faculty members devote a major part of their activities to basic laboratory research related to cancer. Over 70 principal investiga- tions in the Schools of Medicine, Dentistry and Pharmacy are recipients of contracts and grants for research and training related to cancer totalling over $7 million per annum. This represents a nucleus of scientici man- power already committed to the clinical, -research and educational challenges of cancer and available to assist in the rapid translation of important research results to LAC patient care.

• Education Within the Schools of Medicine, Pharmacy, and Dentistry and USC affiliated hospitals are nine NIH supported postdoctoral programs providing training in clinical and research aspects of cancer. The immediate proximity of the Cancer Center to the LAC patient care facility and to medical school and graduate medical programs will allow ready access of students , house officers, and faculty both to the beds and tothe laboratories of the Cancer Center. There are areas of adknowledged excellence among the programs of basic and clinical cancer research, care and education at the Medical Center. However, current cancer activities are conducted in many different locations, with little or no coordination even in areas of endeavor where this would be highly desirable. Therefore, the many advantages which the existing staff, programs, facilities and patient populations can make available to this project remain largely unrealized. The facility will provide for the first time an environment where the appropriate mix of professionals, facilities, and patients can be brought together for the effective communication, coordination, and collaboration which will enhance the overall cancer effort of the institutions involved and enable them to be effectively related to the region they can potentially serve.

NUMBER OF CURRENT FULL-TIME USC FACULTY WITH SIGNIFICANT INVOLVEMENT IN CANCER RESEARCH, EDUCATION, AND TREATMENT SCHOOL OF MEDICINE ................... 118 Departments Anatomy Anesthesiology Biochemistry Medical Education 6 2 7 1 Obs. & Gyn. Pathology Pediatrics Pharmacology 5 14 14 3 Surgery 8 Neurological Surg. 2 Orthopedic Surg. 2 Oto.,Rhino, Laryn. 2 Medicine Microbiology Neurology Opthalmology 22 7 1 2 Phys. Med. & Rehab. Physiology Psychiatry Radiology 1 3 2 13 Urologic Surgery 2 Res. &Train. in Rehab. 1 Post Grad. Med. Edu. 1 S CHOOL OF PHARMACY ................... 11 SCHOOL OF DENTISTRY ................... 11 ~ SCHOOL OF ENGINEERING ................. 4 DIVISION OF BIOLOGICAL S CIENCES ........ 3 TOTAL 147 ~ ---------------------------------------------------------------------- RANK OF CURRENT FACULTY INVOLVED IN CANCER ACTIVITIES Profe s s or 80 Associate Professor 23 Assistant Professor and Instructor. 44 147 -6- ,~~

PRESENT SOURCES AND AMOUNTS OF SUPPORT TO USC FACULTY FOR CANCER RESEARCH AND TRAINING (January 1973) SOURCE NO. OF PROJECTS ANNUAL FUNDING Federal NIH Research Grants 34 $ 1,643,850 NCI Planning Grant (Cancer Center) 1 150,000 NIH Training Grants 10 594,737 NCI Cancer Clinical Investigation Groups 4 689,908 NIH Career Development Awards 4 74,450 NCI Special Virus Cancer Program 1 2,392,550 NIH Other Contracts 3 396,399 National Science Foundation 4 145,177 Children's Bureau 1 152,794 Community Health Services Division 1 88,000. Atomic Energy Commission 1 24,000 Subtotal 64 $ 6,351,865 Private American Cancer Society Research Grants 7 229,843 American Cancer Society Research Professorship 1 17,000 Leukemia Society of America 2 29,750 Council for Tobacco Research 2 135,879 American Medical A s s ociation 1 20,000 All Other Private Sources 10 233,891 Subtotal 25 $ 665,835 TOTAL: 89 $ 7,017,770 ---------------------------------- -------------------- ------------- SITE OF PER,ORMANCE OF ABOVE PROJECTS LAC-USC Medical Center Medical School Dental School Pharmacy School Childrens Hospital of Los Angeles John Wesley Hospital $ 889,298 4,196,498 469,457 141,813 958,639 362,065 $_ 7,017,770 -7-

THE LAC-USC CANCER HOSPITAL AND RESEARCH INSTITUTE BACKGROUND AND HISTORY Several years ago the National Cancer Institute, as one of the National Institutes of Health of the U. S. Public Health Service, activated a Cancer Research Centers Program ... "TO PROVIDE GRANTS FOR THE SUPPORT AND DEVELOPMENT OF CANCER COMPLEXES WHICH COULD ENGAGE IN CLINICAL AND BASIC RESEARCH, IMPROVED DIAGNOSIS AND TREATMENT OF PATIENTS, TRAIN AN EFFECTIVE CANCER CADRE FOR THE FUTURE AND RADIATE INFLUENCE TO UPGRADE CANCER CARE IN SURROUNDING COMMUNITIES. " Recognizing the absence of any major cancer center in the far West, officials of the NCI explored with the USC School of Medicine their possible mutual interest in developing such a project. This led to an award to USC of a grant for support of exploratory planning for a cancer hospital and research institute: Since 1966, a Cancer Planning Committee of the School of Medicine and the L.A. County Department of Hospitals has been exploring plans for develop- ment of a cancer center for this region. The efforts have been supported by a succession of planning grants from the NCI totalling over $500, 000. Thus, planning for a major center in this region for the study and treatment of cancer began five years before the Conquest of Cancer was made a national priority by Congress in 1971. A proposal to join the County in developing a cancer center for this region was presented to the Board of Trustees of the University of Southern California in November 1968 by the President of the University, Dr. Norman Topping. Leadership in sponsoring the undertaking was provided by Mr. Kenneth T. Norris, of the USC Board of Trustees and Chairman of the Medical School Board of Councilors. In December 1968 Mr. Kenneth Hahn, -representing the Los Angeles County Board of Supervisors, and Dr. Topping, announced plans to develop a regional cancer center to be operated jointly by the County and USC. With policy established by officials of the County, USC, and the Cancer Planning Committee, the following five tasks were undertaken: Task I A study of alternatives for a regional cancer program and facility Task II Operational Financial Analysis Task III Immediate Space Needs Study . Task IV Architectural Program Statement, Cancer Hospital and Research Institute . Task V Conceptual Design Drawings, CHRI -8-

A CANCER PROGRAM FOR THE REGION The Cancer Center is envisioned, not simply as a physical facility, but as the focus of a regional program in which the institutions, health specialists and scientists of Southern California would participate and which would in- clude programs of basic and clinical research, clinical care, education and community service. The program and facility was to provide a center of ex- cellence for the region serving the needs of private and public patients alike. CANCER PLANNING COMMITTEE Based upon the understanding between the County and the University the Cancer Planning Committee continued to meet to develop the broad concepts and guidelines concerning the organization and operation of the Cancer Center Program. To ensure the benefits of an interdisciplinary approach and to acknowledge cancer research activities in other health disciplines, representatives from the Schools of Pharmacy and Dentistry were added as were the Chairman of the principal academic departments involved in cancer activities. ORGANIZATIONAL CONCEPTS The Cancer Center is envisioned as the Cancer Hospital and Research - Institute and programs of treatment, research, and education throughout the region for which these facilities will provide the focus. Programs of the Cancer Center will be task-oriented, interdepartmental, and multi- disciplinary rather than following traditional academic departmental organization. They will be developed by the faculty and staff of the. Medical School, its affiliated hospitals and other schools of the University, com- bining the fundamental research and teaching competence of the Uriiversity with the facilities and capabilities of a specialized teaching and research hospital. It will provide the scientific and administrative headquarter-s for programs of clinical cancer investigation, basic research, education, and e service to the health specialists and institutions of the region and to their cancer patients., The planned structure will provide the central focus for Cancer Center• programs; however, it is not planned to physically consolidate all cancer programs into the new facility. Cancer Center programs are expectedto be conducted in the existing facilities of the health science schools of the University, the LAC-USC Medical Center and other affiliated hospitals, including, in particular, the Childrens Hospital of Los Angeles and the John Wesley Hospital. Scientific, clinical and educational programs will be developed, not only by USC faculty and affiliated hospitals, but with scientists, clinicians and health specialists in the hospitals and other scientific and educational institutions in the region. The Cancer Center will provide an additional mechanism for coordination and funding of cancer research, particularly for research which can be developed best in a multidisciplinary, interdepartmental, and collaborative setting. -9-