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the Webb-Waring Institute for Medical Research Annual Report 1969-1970 [St]

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I SCIENCE AND THE UNRELENTING SEARCH FOR TRUTH Thomas Carlyle (1795-1881) the brilliant Scottish historian encouraged more thought about the mysteries of our universe in these words: "The world, after all our science and sciences, is still a miracle; wonderful, inscrutable, magical and more to whoever will think of it." The research scientist, though unconcerned in his work with how this miracle came to be, does take delight in unlocking the door to many of its mysteries. For doing this, Alexander Von Humboldt (1769-1859), the German naturalist, gave us his impression of the scientist's basic responsibility: "The mysterious and unsolved problems of how things came to be does not enter the empirical province of objective research, which is confined to a description of things as they are." Describing "things as they are" by laboratory methods is not completely satisfying to most scientists, who because of their "faith in order" look for reasons beyond the realm of science to justify their faith. In pondering this question, Asa Gray (1810-1888) the eminent American botanist and one time Professor of Natural History of Harvard University, provided this answer: "Faith in order, which is the basis of science, cannot reasonably be separated from faith in an Ordainer, which is the basis of religion." And thus man continues his unrelenting search for truth and for an understanding by which meaning can be measured. THE STAFF Webb-Waring Institute
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TABLE OF CONTENTS COVER PICTURE: Columbine, Colorado State Flower Officers, Trustees and Staff of The Webb-Waring lnstitute ----._._---__---_---_-•__-_---__ Report of the President, Robert S. Liggett --_--•_•-_----_-_----- ----------- __--.---_6 Report of the Director and Principal Investigators: Roger S. Mitchell, M.D., Director and Head, Division of Clinical Research 7 M. L. Morse, Ph.D., Division of Genetics _-------.-_-------- _---- _--_•-----_------_----------_-...__-..... _ 9 Giles F. Filley, M.D., Division of Pulmonary Physiology ----- ------- _----- -._---_------- .---.._------ _10 Alfred J. Crowle, Ph.D., Division of Immunology _----------- _--------- -_--__..... _..-___---.._-.-._--------- 12 Oscar K. Reiss, Ph.D., Division of Biochemistry - ------- .............. _--------- -...... _•._..-_..... _..... _.-_----13 Albert E. Vatter, Ph.D., Division of Cell Biology •____________•_.--_-__--_----_--------- 14 Report of Research and Training Grants (Table 1) ...-............. _......................................................... 15 Publications of Staff Members for the Academic Year (Table 11) _--.__-------- _---w-------- ----- 16 Medical Education (Table 111) ___ ------------ -------------- _........ ...... w---- __.-._-.._--___ __l7 Financiat Report as of June 30, 1970: Statement of Wilkins, Winter and Barrett, Certified Public Accountants Schedule of Changes in Fund Balances ------ .___..--_-_-_----- _•-_________ Balance Sheet _.•-........ -.......... ------------------ ------ ----.._..... - - - _ _ - - - _20-21 Maintenance Fund Income Statement ...------------- _---- _---- _---- _--_--_-._.______.. Report on Memorials, Bequests and Other Contributions: Budget - 1970 - 1971 _-_-.----- - -.. -- _-.._-----........................._._._...__.._____._.._.__.__-.-__.-.-_-_______.---23 Contributions to the Webb-Waring Institute ------------------•-----_-------- _------ _..__.. _..__.__........ 24 Information and Suggestions for Contributions ..---------- -__-•_---___---_--------- -_------- _---- _ ................28 Biographical Notes on Staff Members and Research Associates -................. _.... ...-._._---__-............ .29 Biographical Notes of Research Fellows _.-.......................... -_.......... _ .__.__...._. _._ _...._._31
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THE WEBB-WARING INSTITUTE FOR MEDICAL RESEARCH UNIVERSITY OF COLORADO MEDICAL CENTER, DENVER, COLORADO 80220 OFFICERS DR. ROBERT S. LIGGETT, President MRS. EDWARD D. WHITE, JR., Vice-President MRS. JOHN W. STEWART, Vice-President HENRY W. TOLL, Vice-President MORRIS A. ESMIOL, Secretary-Treasurer MARC L. MILLISON, Assistant Secretary-Treasurer TRUSTEES 1968-1971 1969-1972 1970-1973 Mr. Roger D. Knight (2)* Mr. Gerald Webb Bennett Mrs. George B. Berger, Jr. Mr. Gilbert Mueller (1, 2, 3,) Mr. Robert Donner, Jr. (1, 2) Mrs. Edward D. White, Jr. (3) Mr. Aksel Nielsen (2,3) Dr. John R. Durrance (3) Mr. Morris A. Esmiol(1, 2, 3) Dr. Francis S. North (1) Hon. William S. Jackson (2) Dr. Robert S. liggett (1) Dr. Robert l. Stearns (1) Mrs. John W. Stewart Dr. Gordon Meiklejohn (3) Mr. Henry W. Toll (1) Mr. Joel A. H. Webb (2) Mr. Allan R. Phipps Mrs. James J. Waring (1) Dr. Wm. D. Millett"°* Dr. Theodore T. Puck ''Numbers Indicate members of committees: (1) Executive ;(2) Finance (3) Budget "''Deceased April 17, 1970 Honorary Trustees Mrs. C. H. Boissevain Mr. Alfred Cowles Mr. Quigg Newton Mr. Harold Silver Mr. James B. Day Mr. William W. Grant Mr. Donald Rauth Dr. Edward N. Chapman (also Financial Consultant Board of Trustees) THE INSTITUTE STAFF AND CONSULTANTS Administration Roger S. Mitchell, M.D., Director Carl W. Tempel, M.D., Maj. Gen. (ret.), Program Coordinator M. Laurance Morse, Ph.D., Asst. Director Mr. Charles Wilkins, C.P.A., Auditor & Financial Consultant Albert Starr, Administrative Assistant Division Chiefs Clinical Research Roger S. Mitchell, M.D. Pulmonary Physiology Giles F. Filley, M.D. - Genetics M. Laurance Morse, Ph.D. Immunology University Position - Professor of Medicine - Professor of Medicine - Professor of Biophysics Alfred J. Crowle, Ph.D. -- -- -- - Associate Professor of Microbiology Biochemistry Oscar K. Reiss, Ph.D. - - -- - - - Associate Professor of Biochemistry Cell Biology Albert E. Vatter, Ph.D. - -- - - - - - Associate Professor of Pathology Research Associates David Ashbaugh, M.D. - - D. Boyd Bigelow, M.D. - Edward Byrne-Quinn, M.D. - Wolfgang Hengstenberg, Ph.D. John C. Maisel, M.D. - - Assistant Professor of Surgery Assistant Professor of Medicine Instructor Instructor Assistant Professor of Pathology - - - - Instructor Helvise G. Morse, Ph.D. - Joyce K. Newman, Ph.D. - Thomas L. Petty, M.D. George J. Revis, D.D.S. - Golyn Stahl, M.D. - - - Ray,rtt,and E. Stanford, M!D. - Thomas Vincent, M.D. - - John Weil, M.D. - - Biochemist Associate Professor of Medicine Assistant i n Sur gery , , Resident in Pathology - - Assistant in Pathology Assistant Clinical Professor of Pathology - - Assistant Profa-~n. _; & A- -'°-`-- 1
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THE INSTITUTE STAFF AND CONSULTANTS (Continued) FELLOWS IN RESEARCH AND BRUCE A. BRIAN, M.D. - - - FRANK H. BRUNSTETTER, M.D. - BUFFINGTON B. BURTIS, M.S. - DAVID C. CHAR, M.D. - - - V. ALTON DOHNER, M.S., LT, CDR. USPHS DONALD B. ELLIS, PH.D.* - - - ENRIQUE FERNANDEZ, M.D. - - - YUTAKA FUJITA, M.D.* - - - - - GEORGE A. GRIGGS, M.D. - - - - KEITH HORSFIELD, M.D.* - - - - PETER N. Y. HUANG, PH.D.* - - - VALDEMAR A. Y. LINDQUIST, M.B., B.S.* - KAREN HITCHCOCK O'HARE, PH.D. - - DONALD OLSEN, D.V.M.* - - - - W. PETER PETERSON, M.D. - - - DAVID S. TERMAN, M.D.* - - - - RICHARD C. BRANAN, B.S.* BEATRICE BRET JOHN W. BUTCHER MICHAEL J. CARLON* DAVID CLOSE* VINCENT CORBIN ROLF DAHL* GLADYS DART, B.A. GEORGE H. FAYETTE DORIS GASKIN* MARLYCI: GEORGE ELLY G. GROENEBOER PERRY HACKETT* WALTER L. HATFIELD* BENNIE BETH HIGGINS JUDITH RAY BISBEE* MARGARET BRAUN, B.A. CAROL I. GRANT MARY HALLIWELL *Part Year - - Assistant in Medicine Postdoctoral Research Fellow - Assistant in Medicine Assistant in Medicine Assistant in Medicine Postdoctoral Research Fellow - - Assistant in Medicine Postdoctoral Research Fellow Assistant in Medicine Assistant•in Medicine Postdoctoral Research Fellow - - Assistant in Medicine Postdoctoral Research Fellow Postdoctoral Research Fellow - - Assistant in Medicine Postdoctoral Research Fellow PRIMITIVO ROMERO* G. WAYNE SILVERS, B.A. INGVAR SODAL, B.S. RICHARD SPECK, B.S. JANET STRONG* JO ANN SUCHEY* DANIEL SUKLE* ROBERT TELEPAK, B.S., M.S. BRIAN UNDERHILL JEFFREY WAGGONER, B.A.* WILTZ W. WAGNER, JR., B.A. DIANA WATSON SHARALYN WOODS* MICHAEL YARRON* SECRETARIES JEAN HALVORSON* LYLE B. McMURRY* CAROLE HILLARD JOANNE MIGNEAULT* JOAN JACKAMORE* RUTH S. ROBERTS, MARY LETOURNEAU CONSULTANTS SHELDON DRAY, M.D., Ph.D. Professor and Head Department of Microbiology University of Illinois College of Medicine Chicago, Illinois KONRAD E. BLOCH, Ph.D. Higgins Professor of Biochemistry Harvard University Cambridge, Massachusetts HUDSON HOAGLAND, Ph.D.,Sc.D. President Emeritus Worchester Foundation for Experimental Biology Shrewsbury, Massachusetts J. BURNS AMBERSON, JR., M.D. Professor Emeritus of Medicine College of Physicians and Surgeons Columbia University New York, New York RENE J. DUBOS, Ph.D., Hon. MD., Hon. D.S. Member, The Rockefeller Institute for Medical Research New York, New York WARD DARLEY, M.D. Consultant to the Executive Director Association American Medical Colleges Visiting Prof, of Med., School of Med. IUiniyersity Ilo1f'llCollorad,b Denver, Colorado CLINICAL PULMONARY DISEASES LABORATORY TECHNICAL STAFF KATHERIN L. HILL, B.A.* NANCY HOOVER JUDITH HORSFIELD* KAREN JARRETT, B.A. CAROL JOHNSON, B.A.* KENT JOHNSON, B.S.* JAMES S. KLINE* MARK KUTNIK* DONALD LETCHER* KARIN L. LINDQUIST, M.S. JAMES McQUAiD* ALEXANDER MICCO DALYCE E. MONTGOMERY MARGARET L. MORSE* WILLIAM PENBERTHY, B.S. ALEXANDER HOLLAENDER, Ph.D. Director Biology Division Oak Ridge National Laboratory Oak Ridge, Tennessee EDWARD P. RADFORD, M.D. Professor and Director Department of Environmental Health University of Cincinnati Cincinnati, Ohio WILLIAM B. TUCKER, M.D. Director, Medical Service Department of Medicine and Surgery Veterans Administration Hospital Washington, D.C. HONORARY CONSULTANTS WILLIAM H. FELDMAN, D.V.M. Chief, Laboratory Research in Pulmonary Diseases Department of Medicine and Surgery Veterans Administration Hospital Washington, D.C. ROBERT J. GLASER, M.D. Vice-Pres. for Medical Affairs & Dean Stanford University School of Medicine Palo Alto, California ESMOND R. LONG, M.D., Ph.D. Professor Emeritus of Pathology Univl rsity of Pennsylvarl'a Medical ICen~tdr I' I 15;' Philadelphia, Pennsylvania
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REPORT OF THE PRESIDENT My first year as president of our Institute has been a real educational experience. I haven't yet had time to hang around each investigator's laboratory to see what goes on, but I have visited with each and have a fair idea of the thoughts running through their minds. Another educational experience has been visiting with each of our consultants at the end of his visit. This combined with reviewing all consultant reports has given me a fair idea regarding the direction our Institute should take. The most frequently mentioned consultant recomendation was that we should emphasize our interest in the structure, chemistry, physiology, pathology, im- munology of the lung, and the effect of environment on these various phenomena. In other words, we should become a lung institute - probably the only one of its kind in the world. Next in frequency was,the recommendation that we try to develop a method of operation that would bring about more cooperation between the sundry disciplines represented by our investigators. These were the two most frequently mentioned suggestions. A comment frequently made was the excellent relationship between the Institute and the University. it gives the Institute the "Critical Mass", the inter- disciplinary stimulation so essential to real scientific endeavor. Though at the moment it seems desirable to make certain adjustments in our University relationship to enable us to qualify as a "Public Foundation", we shall jealously guard our affiliation which has been so meaningful to us all. Often mentioned by our consultants was the need to carry on training of post-doctoral fellows as potential replacements for our investigators and director. The need for recruitment of a director to replace Dr. Mitchell, who will be retiring within 5 years was mentioned by two individuals. Though there are other recommendations upon which I shall touch later, this brings us to a discussion of an extremely urgent matter, namely, our building. The Webb-Waring building has reached a point of saturation. We can't adequately train post-doctoral fellows; we can't take on any more investigators until we acquire more space. In fact, we're having trouble finding a place to put the new, badly needed, Xerox machine. We are in no position to recruit a new director because we have no place for him to work. Our present director is a clinician who occupies only an office - his laboratory has been the hospital wards and clinics. The cry among our investigators is that the new director be a research basic scientist. We will cross that bridge when we get there, but whomever we get must have laboratory space. Space in the Medical School is not available and if it were, I'm not sure it would be desirable. The University has approved adding minimally to the South of our existing building with limited extension towards the West. It appears that we can acquire about 10,000 feet of space by extending our present building thirty feet to the South and a little over thirty feet west of our present west line. This addition would measure thirty feet by sixty-six feet and rise a full five stories. Some could remain unfinished until the need became urgent; however, I would predict this is not too far down the road. --- 6 - ~
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Returning to consultants' comments, several praised the balance between basic and clinical research, and one thought we should restrict investigations to matters relevant to the lung. One went so far as to say we should put more emphasis on tuberculosis. Most thought we needed more endowment to give security to our investi- gators and to enable us to assure continuity of funding when and if the government grants dry up. This brings me to another point of degression. I have discovered that the University pays from 13% to 96% of the salaries of our investigators with an. overall average of 53%. More specifically, the Uni- versity pays, 13%, 25%, 48%, 59%, 68% and 96% of the six salaries. Here is another stumbling block in the recruitment road leading towards new investi- gators or a new director. We don't have the salary and we don't have the assur- ance that the University would be willing to continue its benevolent attitude. To summarize, the solution to the Institute's problems is MONEY. We have an excellent staff of dedicated investigators, we have a director of renown, and we have one of the few tung Institutes in the world. The world needs us and we need to grow. We have an inspired and dedicated group of trustees and are continually on the search for more. We are looking towards the newly formed National Heart and lung Institute for a degree of support. The NHLI is still in the formative stage without clearly defined objectives or operative procedures. Before the year is up, we think it will be given some direction. We hope to be able to get matching funds for construction, post-doctoral fellowship funds, and research grant money. As trustees, however, we still have the goal of greater endowment. The tragic loss of Dr. Millett will be felt by all of us for a long time to come. He was a distinguished, dedicated physician sincerely interested in Webb-Waring. ROBERT S. LIGGETT, M.D. President REPORT OF DIRECTOR AND DIVISION OF CLINICAL RESEARCH During the fiscal year 1969-1970, a total of 90 different persons were employed by the Institute; of this number many worked part of the year or part- time. Our average full time equivalent staff has been approximately 50 for the year. The general operating budget request for the past fiscal year was $130,798. When this is added to the $380,500 provided by research grants (Table 1), the total amount of money expended upon our entire program in 1969-1970 amounted to $511,298. Members of the Staff presented papers at 2 international, 25 national and 39 regional and local scientific meetings during the year. Members of the Staff during the same period published 21 papers in scientific journals (Table 11). The Pulmonary Disease Fellowships continue to be one of the most im- portant programs with which the Institute is concerned. The first year of this 3 -7-
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program emphasizes acute respiratory care, pulmonary disease consultations and tuberculosis diagnosis and treatment. The second year stresses teaching and research. The 8 trainees were supported this year by the Department of Medicine, Denver General Hospital, Denver Veterans Administration Hospital, The National Tuberculosis and Respiratory Disease Association-American Thoracic Society, the U.S. Air Force, the U.S. Public Health Service, The American College of Physicians and the Francis S. North Foundation. We are grateful to those who have provided the funding to make these Fellowships possible. Our first-year Fellows in Pulmonary Disease in 1969-1970 have been Drs. Bruce Brian, Buffinton Burtis, Enrique Fernandez (American College of Physicians), George Griggs (U.S. Air Force), Valdemar Lindquist and Peter Peterson. Second year Fellows were Drs. David Char (Francis S. North Foundation) and V. Alton Dohner (USPHS). In the face of the ever increasing problem of chronic lung diseases in our country - affecting at least 10 million Americans according to the U.S. Public Health Service surveys - the training of pulmonary disease specialists and teachers is indeed important. At a recent meeting of the newly created National Heart and Lung Institute the participants brought out the existence of at least 100 funded, unfilled, full time teaching positions in Pulmonary Disease in U.S. Medical Schools. The special Research Fellowship Fund, established by the Institute Board of Trustees in January 1969 to employ postdoctoral research Fellows other than those provided for under a training grant from the U.S. Public Health Service (Table i), received support from the Donner Foundation ($10,000), Boettcher Foundation ($10,000) and the El Paso County Tuberculosis and Respiratory Disease Association ($500.00). With gratitude for the help received to date, I should like to emphasize that a total of approximately $50,000 annually will be needed to meet the growing needs of this program. This need is in recognition of the fact that talented young investigators become available for employment at,various times when funding may not be immediately available; its existence will enable us to take advantage of their services and will help make possible the infusion of new talent upon which the institute must depend for intellectual and productive growth. It should be noted that the total of government support in the form of research grants fell by approximately $20,000 in the past year (Table I). Income from other sources is being sought in order to avoid the loss of trained and essential research personnel - particularly members of our technical and administrative staff - who are essential to the continuation of projects under way. Two interesting new developments nationally are worthy of note. The National Heart Institute has recently been changed to the National Heart and Lung Institute, and the American Heart Association is in the process of expanding its interests in lung disease. These changes have occurred in recognition of the growing importance of heart disease caused by chronic lung disease, the difficulty at times of sorting out and separately treating heart and lung problems, and the present inadequacies of training and treatment facilities for pulmonary problems. I have served on committees advising both agencies. These two major agencies will probably increase support of lung oriented research and training in the months to come. During the present year we were honored and greatly aided by having visits by 3 regular and one special Consultants: Dr. Sheldon Dray in August 1969, Dr. -8-
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William Tucker in January 1970, Dr. John Goldsmith in February 1970 (special) and Dr. Hudson Hoagland in May 1970. The 1970 Aspen Emphysema Conference, the 13th in the series, was again an outstanding success and would not have been possible without much effort on the part of members of the Institute Staff. The Division of Clinical Research continued to follow 258 surviving patients with chronic airways obstruction in our Emphysema Registry and added 62 cases to the ongoing clinical-physiological-morphological study of human lungs. We feel we are getting closer to understanding the various causes of airways obstruction; these now appear to be permanent loss of small airways from infections, loss of airway wall integrity (atrophy) and tractional support (destructive emphysema) and inflammatory swelling and mucus plugging. The NIH grant supporting this project was renewed in May 1970 for four more years. It is a pleasure to report that this project will now come under the jurisdiction of our new Division of Experimental Pathology to be headed by Dr. John C. Maisel who has joined our investigative team as of July 1, 1970. The Budget request for the coming year shows a substantial increase. The reasons for this increase are principally the following: the addition of a new Division Head (Dr. Maisel) and Webb Building remodeling expenses occasioned thereby; the termination of Dr. Morse's 10-year U.S. Public Health Service Career Development Award with consequent Institute funding of most of his salary (balanced to a considerable extent by the now available income from the James J. Waring Chair of Biology Fund); an increased contingency fund (because of the currently uncertain government grant picture); and salary increases. On behalf of the entire Staff, may I express again to our Trustees and many benefactors our deep appreciation for the continued enthusiastic and generous support of our scientific program. ROGER S. MITCHELL, M.D. DIVISION OF GENETICS Research on the genetics and biochemistry of Staphylococci has continued during the year with particular emphasis on sugar utilization. The enzyme phosphb- B-galactosidase has been purified and partially characterized. It is the first enzyme of its kind to be so characterized. It is responsible for the splitting of phos- pholactose (milk sugar) formed by the transport mechanism of the staphylococcal cell. With Dr. Helvise G. Morse we have continued our fundamental study of metabolic regulation in bacterial cells. This research has been approved, but not funded by the NIH, and it is hoped that it will go forward more rapidly with NSF support beginning in the summer.of 1970. In this study we are learning how a simple cell, yet whose genetics is well understood and manipulatable, regulates its metabolic system. !t is planned to apply the information obtained with this system to mammalian cells in culture within a year or two. During the year, Dr. Don K. Button, Professor of Marine Science of the - 9-
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University of Alaska spent a sabbatical year in the laboratory. He participated in various areas of research, including maltose metabolism in Staphylococcus and in the research to produce larger amounts of the anti-leukemic agent, L- asparaginse. He picked up many new techniques adaptable to his studies on marine organisms at the Institute for Marine Science. In addition some pre- liminary studies were made of hydrocarbon utilizing marine microorganisms. These organisms are important in the elimination of oil spills and slicks in the ocean, since they metabolize readily such things as crude oil. The program to produce better strains of the bacterium Escherichia coli, (supported by the American Cancer Society) the source of L-asparaginase, the anti-leukemic has progressed slowly. The procedure proposed was to place cells in an environment where those cells with increased amounts of L-asparaginase would be selectively favored, and therefore isolated from the rest of the pop- ulation. After some months of work it was found that this was not directly achievable, since the limiting factor was not L-asparaginase production, but entry of the substance on which it acts (L-asparagine) into the cells. It was therefore necessary to remove this limiting factor (by making mutants which transport aspara- gine more rapidly) before starting the initially proposed procedure. This has now been done. The programs described briefly above have in their own right been interesting and productive. In addition, they have provided training, in thought and in experiment, that is applicable to higher cell forms such as mammalian cells in culture. Each of the above programs is expected to last one to two years longer. During this time it is proposed to prepare a program on human cells in culture, perhaps lung cells, in which all the technics employed in our previous studies can be applied to the study of human cells. Coupling this with information on human genetics, it is expected that a research 'program will become available in about three years which will contribute not only to fundamental knowledge of the cell, but may prove useful in the study of human disease, such as emphysema, and in understanding the action of environmental agents on cells. M. L. MORSE J. J. Waring Chair of Biology DIVISION OF PULMONARY PHYSIOLOGY The past year's investigations of the pulmonary mechanisms of oxygen, carbon monoxide and carbon dioxide transport, of the physiological regulation of breathing, of the way the lung can be injured by fat embolization and of certain factors responsible for shortness of breath in patients with lung disease can be summarized by listing the publications by the staff of this division. Flow patterns in the upper airways were measured in living men and in lucite casts of the mouth and larynx of a cadaver. The control of breathing by oxygen tension was studied using a fast 02 analyzer and on-line computer. Disabled patients were shown to breathe slower and deeperr with pursed lips than without, improving their ventilatory efficiency without changing their arterial blood oxygenation. Cigarette smoking was shown to cause serious but transient decreases in blood oxygen pressure. r 10 -
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In press or preparation are the following papers: "Blood Gas and Acid Base Regulation." Filley, G.F. Lea & Febiger, Philadelphia. "Evaluation of hypoxic ventilatory drive - findings at high altitude." Weil, J. V., E. Byrne-Quinn, I. E. Sodal, G. F. Filley, and R. F. Grover. In HYPOXIA, HIGH ALTITUDE AND THE HEART, edited by J. H. K. Vogel, S. Karger, Basel, 1970. "Rapid reversal of smoking-induced arterial hypoxemia at altitude." Brewer, G. J., J. W. Eaton, R. F. Grover, and J. V. Weil. Am. Soc. for Clin. Invest. (Abstract) "Complications of the Guillain-Barre syndrome." King, E. G. and H. Jacobs. Canadian Med. Assoc. J. "Acid regulation and CO2 retention." Filley, G. F. Chest. "Alterations in pulmonary microanatomy after fat embolism: in vivo observations via thoracic window of the oleic acid-embolized canine lung." King, E. G., W. W. Wagner, D. G. Ashbaugh, l. P. Latham, and D. R. Halsey. (Submitted to Chest.) "Consumption coagulopathy in experimental fat embolism." King, E. G., Weily, H. S., E. Genton, and D. G. Ashbaugh. "An automatic method for chromatographic gas analysis using a helical gas collector." Sodal, I. E., L. V. Corbin, J. V. Weil, and G. F. Filley. "The effects of breath holding on the responses of the cardiovascular system to isometric exercise." Lindquist, V. A. Y., and J. V. Weil. "Ventilatory control in the athlete." Byrne-Quin, E., J. V. Weil, I. E. Sodal, F. G. Filley, and R. F. Grover. (Submitted to J. A. P.) " Acquired attenuation of chemoreceptor function in chronically hypoxic man at high altitude." Weil, J. V., E. Byrne-Quinn, (. E. Sodal, G. F. Filley and R. F. Grover. "Central airway resistance in excised emphysema lungs during artificial ventilation." Silvers, G. W., T. L. Petty, R. S. Mitchell, G. F. Filley and J. C. Maisel. (Submitted to Am. Rev. Resp. Dis.) Plans for work in the next few years will be to intensify the investigations al- ready being carried out by the staff in the following areas. 1. Measurements of the geometry and physical properties of lung tissues obtained at autopsy and of the aerodynamics of flow through the bronchial system under controlled laboratory conditions. 2. Further development and testing of mathematical models of the lung as a carbon monoxide extractor in an effort to devise more useful tests of pulmonary diffusing capacity. 3. Continued use of the surgically implanted window for direct microscopic observation of the dog lung under normal conditions, during the breathing of toxic materials such as carbon monoxide and with various experimental insults to the lung similar to those which occur in human disease (e.g. fat embolization). 4. Determination of the regulation of breathing by changes in O,, and CO- pressures at altitude, in athletes, in patients and under special circumstances such as treadmill exercise and during CO-inhalation. Computer controlled in- strumentation is essential for this work. 5. Attempts to understand the overall regulation of the oxygen and CO: -11-
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transport systems of the body - not only how the pulmonary and cardiac mechanisms are controlled, but how oxygen and acid-base demands are bio- chemically regulated at the tissue level. It is hoped that the aid of a physical chemist can be enlisted for part of this work. 6. For measuring air pollutants and their effects on man, new techniques for gas analysis and computerization of the measurement process is of increasing importance. Significant progress has been made in our laboratory in improving and adapting mass spectrometers for use in cardiopulmonary research. Computeri- zation of the laboratory procedures will be emphasized. GILES F. FILLEY, M.D. DIVISION OF IMMUNOLOGY Hypersensitivity. - Our continuing experimentation on control of induction of delayed hypersensitivity to various antigens in mice, guinea pigs, and rabbits has suggested operation of a heretofore unsuspected mechanism which regulates induction and development of delayed-type hypersensitivity. This mechanism functions through a special humoral antibody which can specifically repress the earliest phases of sensitization. We have identified this antibody as y, globulin in mice, have determined conditions for its production and for demonstration of its effects, have shown that it is effective in rabbits, guinea pigs, and mice, although not always accross species lines, and that it can account for an immunologic unresponsiveness of previously unknown cause. As a consequence, we have been able to transfer this type of unresponsiveness from tolerant mice to normal mice passively with serum and adoptively with living spleen cells. These advances promise rational rather than empirical development of specific techniques for avoid- ing homograft rejection, for overcoming certain kinds of malignant tumors, for preventing or alleviating allergic and autoallergic diseases, and for selecting helpful (i.e., immunizing) as opposed to useless, competitive, or even harmful (i.e., allergic) immunologic responses in man. On a theoretical level, our findings suggest a single explanation for several different kinds of immunologic unresponsiveness studied by other laboratories for which previously there has been no unified concept. From our experiments on induction of delayed hypersensitivity we have learned also of ways to improve the effectiveness of Freund's adjuvant. We have used these improvements to show, for instance (in experiments with Dr. Noel Rose of Buffalo, New York), that mice injected with mouse thyroid extracts will develop auto-allergic thyroiditis. Tuberculoimmunity. - Our experiments indicate that the immunizing antigen which we have isolated from the tubercle bacillus should be a useful improvement over BCG for practical immunization of man because it does not induce tuberculin hypersensitivity, it is more stable, and it is simpler. We have developed an ef- ficient one-step purification procedure for this antigen and a way of changing it chemically for increasing its immunizing effectiveness., We have also developed techniques for preparing in vivo-grown tubercle bacilli and then challenging ex- perimental animals with these bacilli by inhalation rather than by injection so as most closely to approximate natural infection in man for realistic evaluation of our vaccine. Results - from these various efforts have encouraged Lincoln -12--
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ind cardiac ds are bio- E a physical r techniques bf increasing n improving Computeri- af induction and rabbits :h regulates mechanism repress the : globulin in ation of its :e, although -nmunologic ~ have been ormal mice 1 advances s for avoid- tumors, for aing helpful e., allergic) a suggest a onsiveness no unified f we have We have Noel Rose Ill develop .ng antigen iprovement ~ tuberculin oed an ef- :hanging it developed 'enging ex- :tion so as iluation of :d Lincoln Laboratories, a pharmaceutical company in Decatur, Illinois, to underwrite ad- ditional experimentation with this vaccine leading to and including field trials with it in human beings. Research on human secretions. - Experiments by Dr. George Revis on the identification of lysozyme in human tears and saliva have nearly been completed. They indicate that lysozymes from the two sources differ antigenically and e l ectro p h o reti ca l ly. Training. - Postdoctorate fellows who have worked in this laboratory during the past year included David Terman, M.D., George Revis, D.D.S., and Frank Brunstetter, M.D. This Division has been responsible for the reintroduction of a course in the Medical School on the subject of delayed hypersensitivity. Dr. Crowle is composing the second edition of his book "Immunodiffusion", which he hopes to complete late this year. ALFRED J. CROWLE, Ph.D. DIVISION OF BIOCHEMISTRY Knowledge of the biochemical processes of normal lung tissue is required in order to understand the lesions that are involved in various diseases. Bio- chemical information about the normal lung is also essential for studies of effects of air pollutants on the lung. For these reasons, the biochemistry division of The Webb-Waring Institute has been investigating certain biochemical aspects of the normal mammalian lung. At first, we developed techniques to permit us to work with lung tissue. Isolation and separation of subcellular organelles from the lung and studies with these preparations led us to the identification of some of the chemical reactions found uniquely in the lung. The results of these investigations directed us toward our present areas of study. The lung requires the presence of surface-active (detergent-like) compound for its normal function. We have isolated and purified this material and have obtained proof that "it" comprises several different surface active species of molecules. We assume that all species are responsible for the observed physiological action. They all contain protein and lipid (lipoprotein). The protein of one of these complex molecules is composed of a very unusual amino acid combination. We are now attempting to elaborate the total comp- osition of these molecules. The next step will be studies that are directed to find out how these molecules are made by the lung and how they are broken down. The study of the synthesis and degradation of molecules has in several instances led to an understanding of disease processes. Another interesting aspect of the pulmonary lipoproteins is that they are insoluble in water and can be made to form membranes similar to those which are part of all living cells. This material contains fewer components than the lipoproteins of most membranes, and there- fore is considerably simpler to study. We hope to gain some insight into the structure of membranes from physical-chemical studies of the lipoprotein from lung. Some proteins that we believe to participate in the metabolic reactions of the pulmonary surfactant are enzymes which we have been studying in col- laboration with the Division of Cell Biology (Drs. Vatter, Newman and O'Hare). We have established that these enzymes are most prominent in the same cell type in the lung which is thought to be implicated in the metabolism of the pulmonary -13-
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surfactant. Another observation which suggests that these enzymes are connected with the lipoprotein is the fact that they appear at the same time in embryonic de- velopment as the pulmonary surfactant. Because of this correlation, we are now investigating possible changes of these enzymes in certain pulmonary diseases such as the respiratory distress.syndrome in infants. Our observation that these enzymes are inhibited when animals are exposed to some pesticides suggests a possible mechanism of attack of environmental pollutants on the lung. We are now purifying these enzymes from lung to learn more about their function and the effect of some pollutants on these enzymes. OSCAR K. REISS, Ph.D. DIVISION OF CELL BIOLOGY Our studies of lung biology are directed to the understanding of lung structure, development and function. We are studying these phenomena in fetal, newborn, and adult animals. Pulmonary physiology is affected by changes in the metabolism of the lung which in turn is controlled by the component enzymes. For this reason, enzyme studies are useful tools for monitoring lung metabolism. The approach we are using to study lung structure and function is unique. We are concerned with developing and mature tissues with special emphasis on the type and location of the enzymes. Changes in the type and location of certain enzymes occur at different stages of development and these are a reliable index for aspects of cellular development and function in the lung. To be able to analyze changes of enzyme components in the lung during growth, we established special assay methods that permit us to see where the enzymes are located in the tissues and to determine certain of their chemical properties. One important assay method adopted in our laboratory for the studies of lung enzymes is electrophoresis. This technique permits us to separate enzymes on the basis of their electrical properties and has been useful in demonstrating that there are seven or eight different enzymes in the lung of the special class we are presently studying. The next step will be to separate and purify these enzymes so that we can characterize their properties, establish with accuracy their cellular origin and functional location. Antibodies will be produced to these enzymes and used to trace any changes in the enzyme patterns in lung tissues. With these methods, we have conducted pilot studies which demonstrate our ability to examine substances from the environment and tobacco smoke to determine the effect of the compounds on enzymes of the lung. It is well estab- lished that an interference with an enzyme affects its functions which in turn modifies cellular processes and tissue structure. The final response in such a situation is usually detrimental to the organism and is expressed in disease. For these reasons, the aim of our research is to continue our studies on the morphology and enzyme distribution in the normal and pathologic mammalian lung with the major emphasis being devoted to the establishment of a sound understanding of the morphological and functional aspects of the normal lung. With the under- standing of normal lung cells, we will be able to study their diseased states. ALBERT E. VATTER, Ph.D. P DR.~ Divts Geni $54; DR. Divrc Imm $23 DR. Div Cti Re: $6( DR Di, Pu Ph $1 D t E C s -14-
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onnected ionic de- are noW diseases ,at these ggests a We are ion and of lung in fetal, :s in the 1zymes. ,bolism. unique. asis on ' certain 3 index xb(e to blished ated in oorfiant ,mes is asis of re are esently /e can n and sed to TABLE I RESEARCH AND TRAINING GRANTS - 1969 - 1970 PRINCIPAL I TITLE OF RESEARCH PROJECi GRANTING AGENCY* ANNUAL AMOUNT Present Support Ends IHVESTIGATOR Career Development Award USPHS $ 28,900 12/31/70 DR. MORSE Division of Molecular Basis of Carbohydrate LIFE INS. 9 600 6/30/72 Genetics Transport in S. Aureus Med. Res. Fund , $54,300 ACS Genetic Studies ACS 15,800 2/28/71 Delayed Hypersensitivity in Mice USPHS 11,400 2/28/70 DR. CROWLE Production and Testing of Tubercle Division of $acilius Immunogen USPHS 10,200 1/31/70 Immunotogy The Salivary Proteins (Dr. George UCMC Revis) GRS #141 700 5/31 /70 $23,300 Enhancing Antibody-Mediated UCMC Tolerance in Mice GRS #254 1,000 4/30/71 DR. MITCHELL Division of Correlation of Premortem and Clinical Postmortem Lung Function USPHS 60,200 5/31 /74 Research and Pathology $60,200 The Chemical Engineering of Pulmonary Gas Transport in Man DA 46,100 12/31/70 DR. FILLEY Cardiopulmonary Disability for Division of Muscular Exercise USPHS 32,500 8/31/70 Pulmonary Physiology Pulmonary Training USPHS 35,200 6f30/71 Pulmonary Microcircuiatory Hemo- $151,700 dynamics and Oxygen Transport NSF 22,100 8/31/70 Social and Rehabilitation Services HEW 15,800 4/30/71 DR. REISS Lipid and Carbohydrate Metabolism in Mammalian Lun s USPHS 25,400 5/31/74 Division of g Biochemistry $57,800 Biochemical Studies of the Pulmonary Surfactant ''4 32,400 10/31/70 DR. VATTER Division of Biochemical and Histochemical Cell Biology Investigations of Enzyme Systems AMA 33,200 1/31/71 in Mammalian Lung $33,200 GRAND TOTAL i $380,500 ~ Instrate ~ke to ^ estab- li turn ! ich a For ology with '`Granting Agencyr nding inder- S. ACS - American Cancer Society AMA--American Medical Association DA-- Department of the Army HEW -- Department of Health, Education and Welfare NSF-- National Science Foundation UCMC--Univenity of Colorado Medical Center USPHS - U.S. Public Health Service -15-
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TABLE 11 PUBLICATIONS OF WEBB-WARING INSTITUTE STAFF - 1969-1970 340. La Via, M. F. and Vatter, A. E.: A Morphologic Study of the Terminal Events of Primary Antibody Response. J. Reticuloendofihelial Society, 6:221-231, 1969. 341. Wagner, W. W., Brinkman, P. D., Baker, D. B. and Filley, G. F.: Erythrocyte Photomicro- graphy: Contrast Control by Monochromatic Transillumination. J. Biol. Photo. Assn., 37:156-162, 1969. 342. Hengstenberg, W. and Morse, M. L.: An Improved Method of Synthesis of Beta-D- Galactopyranoside 6-Phosphate. Carbohyd. Res., 10:463-465, 1969. 343. Crowle, A. J. and Hu, C. C.: Adoptive Transfer of Immunologic Tolerance Into Normal Mice. J. Immunol., 103:1242-1247, 1969. 344. Macintyre, E. H., Grimes, R. A. and Vatter, A. E.: Cytology and Growth Characteristics of Human Tumor Astrocytes Transformed by Rous Sarcoma Virus. J. Cell Sci., 5:583-602,1969. 345. Hengstenberg, W. K., Penbarthy, W. K., Hill, K. L. and Morse, M. L.: Phosphotransferase System of Staphylococcus Aureus: Its Requirement for the Accumulation and Metabolism of Galactosides. J. Bact., 99: 383-388, 1969. 346. Morse, M. L. and Pollock, B. F.: Reversion Instability in the Galactose Operon of Escherichia co/i. J. Bact., 99:567-569, 1969. 347. Mitchell, R. S.: The Outlook for Subjects with Emphysema and Chronic Bronchitis. New Eng. J. Med., 280:445-446, 1969. 348. Abram, D., Mitchen, J. R., Koffler, H. and Vatfer, A. E.: Differentiation Within the Bac- terial Flagellum and Isolation of the Proximal Hook. J. Bact., 101:250-261, 1970. 349: O'Hare, K. H. and Sheridan, M. N.: Electron Microscopic Observations on the Morphogenesis of the Albino Rat Lung, with Special Reference to Pulmonary Epithelial Cells. Am. J. Anatomy, 127:181-206, 1970. 350. Olson, D. E., Horsfield, K., Wagner, J., Wagner, W. W. and Filley, G. F.: Investigation of Flow Patterns in the Upper Airways During Mouth Breathing. Am. Rev. Resp. Dis., 101:(3), 456, 1970. 351. Well, J. V., Bryne-Quinn, E., Sodal, 1. E., Fiiley, G. F. and Grover, R. F.: Ventilatory Control During Hypoxia in Normal Man. Am. Rev. Resp. Dis., 101:(3), 458, 1970. 352. Schnebli, H. P., Vatter, A. E. and Abrams, A.: Membrane Adenosine Triphosphatase from Streptococcus faecalis. J. Biol. Chem., 245:1122-1127, 1970. 353. Mitchell, R. S.: Answers to Quesfiions on Suppurative Lung Disease. Hospital Medicine, 5:(31, 54-68, 1970. 354. Crowle, A. J. and Hu, C. C.: Studies on the Induction and Time Course of Repression of Delayed Hypersensitivity in the Mouse by Low and High Doses of Antigen. Clin. and Exper. Immunol., 6:(3), 363-374, 1970. 355. Mitchell, R. S.: Differentiation of Chronic Lung Diseases. Hospital Practice, 5:(4), 46-57,1970. 356. Olson, D. E., Dart, G. A. and Filley, G. F.: Pressure Drop and Fluid Flow Regime of Air Inspired into the Human Lung, J. Appl. Physiol., 28:(4), 482-494, 1970. 357. Mueller, R. E., Petty, T. L. and Filley, G. F.: Ventilation and Arterial Blood Gas Changes Induced by Pursed Lips Breathing. J. Appi. Physiol., 28:(6), 784-789, 1970. 358. Well, J. V., Bryne-Quinn, E., Sodal, 1. E., Friesen, W. 0., Underhill, B., Filley, G. F. and Grover, R. F.: Hypoxic Ventilatory Drive in Normal Man. J. Clin. Invest., 49:1061-1072,1970. 359. Mitchell, R. S. and Lester, W.: Clinical Experience with Cycloserine in the Treatment of Tuberculosis. Scand. J. Resp. Dis., Suppl. No. 71, 94-108, 1970. 360. Hengstenberg, W., Penberthy, W. K. and Morse, M. L.: Purification of the Staphylococcal 6-Phospho-Beta-D-Galactosidase. Eur. J. Biochem., 14:27-32, 1970. 361. Frlley, G. F.: The Respiratory Function of the Blood. Red Cell Metab. and Function, 177-190, 1970 (Plenum Press). 1 2. 3. 4, 5. ~ c 6. f c
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TABLE III ~-i 970 Events of Primary :)cyte Photomicro- iol. Photo. Assn., thesis of Beta-D- ince Into Normal Characteristics of 5:583-602, 1969. iosphotra nsfe rase and Metabolism tose Operon of Bronchitis. New Within the Bac- 1, 1970. I-vations on the r Epithelial Cells. Investigation of ;sp. Dis., 101:(3), F.: Ventilatory 3, 1970. ~osphatase from spital Medicine, of Repression of igen. Clin. and ~:(4), 46-57, 1970. v Regime of Air 9 Gas Changes 4ley, G. F. and 061-1072,1970. e Treatment of Staphylococcal and Function, 1. 2. 3. 4. 4 5. 6. 7. 1i MEDICAL EDUCATION Teaching, consultation and other contributions of the Staff Webb-Waring Institute for Medical Research Staff assignments, University of Colorado Medical Center: Professorships and other full- time teaching appointments are held by 6 members of the Staff in the Departments of Medi- cine, Biophysics, Microbiology and Biochemistry. Participation in predoctoral and postgrad- uate medical education of the Medical School and University Hospital is part of this respon- sibility. Training Programs of the Institute. a) Fellowship training is provided for 1-2 years or more in the specialty of pulmonary diseases and 10 physicians are in the present program. In the last ten years 42 clinical Fellows and 16 research Fellows have completed training. Many of these are now dis- tinguished specialists and some have established comparable teaching programs else- where. In addition, medical residents of Colorado General Hospital participate in similar training programs of the Institute for shorter periods each year. b) Training of foreign physicians is included under the exchange program and sponsor- ship of the "Educational Council for Foreign Medical Graduates," averaging 1-2 phy- sicians annually for 1-6 months each. c) Sponsorship and participation in postgraduate pulmonary disease courses. Several such courses averaging 5 days for each are scheduled in the Denver area each year. d) Predoctoral and postdoctoral assignments in medical research, workshops in medical technology, and on the job training are provided. Approximately fifty people working in the laboratory in some "training status" have gone on to technical or professional careers (M:D., Ph.D. and others) in the past decade. The James J. Waring Visiting Professorship in Medicine, presently supported by the North Fund, provides for exchange visits of leading national and international scientists and physicians. Cross fertilization of ideas occurs in this stimulating program. state and local health departments and other institutions. Consultant services: Members of the Staff serve as Consultants to governmental agencies, Committee memberships: These include the Medical School, medical societies, health agencies and national professional associations. Participation in local, regional, national and international medical meetings: Lectures, panels, and exhibits. Medical publications of the professional staff: Approximately 25 to 30 papers are now being published each year and nine medical books are numbered among the publications of Staff members to date (listing in Annual Reports of the Institute).
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WILKINS, WINTER AND BARRETT CERTIFIED PUBIiC ACCOUNTANTS August 5, 1970 The Webb-Waring Institute for Medical Research Colorado Springs, Colorado Gentlemen: We have examined the balance sheet of the Webb-Waring Institute for Medical Research as of June 30, 1970, and the related statements of income and expenditures and changes in fund balances for the fiscal year then ended. Our examination was made in accordance with generally accepted auditing standards and accordingly included such tests of the accounting records and such other auditing procedures as we considered necessary in the circumstances. In accordance with practices followed by non-profit organizations, no pro- vision has been made for depreciation of buildings or equipment. The accounts shown do not include the special grants received and dis- bursed by the University of Colorado. No accounting for these grants is made by the institute nor are they covered by this opinion. In our opinion, the accompanying statements present fairly the financial position of the Webb-Waring Institute for Medical Research at June 30, 1970, and the results of its operations for the year then ended, on a basis consistent with that of the preceding year. Respectfully submitted, /s/ Charles Wilkins WILKINS, WINTER AND.BARRETT --18 --
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THE WEBB-WARING INSTITUTE FOR MEDICAL RESEARCH SCHEDULE OF CHANGES IN FUND BALANCES For The Year Ended June 30, 1970 Exhibit "D" MAINTENANCE FUND ENDOWMENT FUND JAMES J. WARING CHAIR OF BfOLOGY FUND ROBERT DONNER CHAIR OF MEDICAL RESEARCH TOTAL ALL FUNDS Balances, July 1, 1969 ._._._.__._.___.____$602,067.22 $1,472,237.47 $376,148.29 $505,270.75 $2,955,723.73 Maintenance Fund Net Income (Exhibit "B") --------- _______$ 35,235.93 $ 35,235.93 Endowment Fund General contributions $ 30,730.31 $ 30,730.31 Margaret Liggett Memorial Fund contributions 110.00 110,00 I James J. Waring Memorial Fund contributions ____.___---- ___ 51,030.41 51,030.41 Increase of cash value of insurance 2,334.76 2 334 76 0 , . Securities - gain on sale 270,085.85 270,085.85 ~ Tarbox Memorial Fund interest ..... __ 344.34 344.34 Tarbox Memorial Fund dividends 233.75 233.75 Tarbox Memorial Fund contributions 1,000.00 1,000.00 James J. Waring - Chair of Biology Fund: Interest $ 10,803.24 10,803.24 Dividends 5,822.16 5,822.16 Gain (loss) on sale of securities (41,646.00) (41,646.00) Robert Donner - Chair of Medical Research: Interest _________. $ 13,081.32 13,081.32 Dividends 10,931.06 10,931.06 Gain (loss) on sale of securities 2.43 243 Less: Transfer to Maintenance Fund (640.43) (23,568.12) (24,208.55) Safekeeping and trust services (11.41) (444.26) (455.67) Total additions . ..... _$ 35,235.93 $ 355,217.58 $ f25,020.60) $ 2.43 $ 365,435.34 BALANCES, JUNE 30, 1970 _....... _______$637,303.15 $1,827,455.05 $351,127.69 $505,273.18 $3,321,159.07
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THE WEBB-WARING INSTITUTE FOR MEDICAL RESEARCH BALANCE SHEET June 30, 1970 Exhibit "A" MAINTENANCI FUND ASSETS Cash in banks ........... ---------------- -----_ ------- -------------- ... -•----••----... $ 15,054.47 Accounts receivable -- TB & RD Ass'n ---•--------•--------------------- ----------- ------- --•.... 666.13 Accounts receivable - others _-.-_----___....... _------ _____.......... ____------- ______......... 713.40 Securities - stocks (See Note 1) -________________________.......... _---- __________ Securities - bonds, debentures and notes (See Notes 1 and 4) ...... _.......... 40,000.00 Securities - Tarbox Memorial Fund (See Note 1) .......................................... Notes secured by mortgages _-_.---------- --.--••_•-_•_-.-__-.-__•.__-•_-•__-•------ --_••-_-•_. Life insurance: Prepaid premium --- - -- - -•------ ------ ------- ............. Cash surrender value - - - ------------ .... _.... ------------------- --------- Dividends receivable ----- ------------ -•____ _ .__---_---_-........ _...... ___..•.... _-____-___ Leasehold: Gerald B. Webb Memorial Building (cost) (See Note 2) --...... 441,000.69 Equipment (cost) (See Notes 2 and 3) ---------------------------------------- Y..... _...... -•_.-- 139,837.94 Insurance deposits _ ............ -..... -.... ---------------- -------------- ------........ _ 125.00 Interfund accounts: Due from Endowment Fund ----- -......... ------- --...... _................. -.__-..--. 127.19 TOTAL ASSETS _.......... ________________ --------------- $637,524.82 LIABIUTIES AND FUND BALANCES Liabilities Accrued payroll taxes _......... ---•------------•------------------------------------ ------- $ 221.67 Due to Maintenance Fund _•__--------- ------------------------.-__.-------------------.------_.--_•- TOTAL LIABILITIES ------------------------------------------------ -.------._.--._--_.---.---.221.67 Fund Balances Maintenance, Endowment and other funds .._----- _---- -______..___ .._.... $602,067.22 Tarbox Memorial Fund _........ -----_..--_._--------- _•__---- --.---..•_._•....... _________ James J. Waring Memorial Fund _..__.._--•_---------- - ____.__...._ Raymond Young Memorial Fund .... .-_---------------_...-..-_------ _.-------- _---_---- Margaret Liggett Memorial Fund ----- ._••-_W_------ _ ---- --------- .___.---- __.------- __-_- Current year excess of income over/(under) expenses -_________________----•-_ 35,235.93 TOTAL FUND BALANCES -----_- ................_-___._---_-.---.-------.-------._.-_--_-_$637,303.15 TOTAL LIABILITIES AND FUND BALANCES __•_------- _-------- ________-_-•-_--..-$637,524.82 NOTES, 1. Values as set forth in Exhibit "A" for securities of stocks and bonds are shown at cost or fair market value at the date of the contribution. These values are also compared to the fair market value as of June 30, 1970, on Schedules 1, 2, 3 and 4 for each of the endowment funds. 2. Depreciation or amortization has not been considered on furniture, fixtures, equipment or building because, in our opinion, the Institute is a non-profit public organization and is not subject to either Federal or State income taxes. 3. A physical examination of equipment was not made, the amount shown ($139,837.94) is token from the books and records with emphasis on determining approval for acquisition and the cost of the asset acquired. 4. Research Fellowshio Contributionso During the post year, the Institute received $20,500.00 for the defraying of certain Fellowship salaries. Prior to June 30, 1970, this money was not used and is held intact in the Maintenance Fund for use in the 1970-71 fiscal year. -20- I $ $ $1,409, 11, 39. 10, 1, 355,', $1,827,c $1,827,5
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ICH . $A" CE ENDOWMENT FUND JAMES J. WARING CHAIR OF BIOLOGY FUND ROBERT DONNER CHAIR OF MEDICAL RESEARCH TOTAL BOOK VALUE 4.47 5,786.50 $ 6,748.35 $ 532.64 121 96 $ 28 13 6 . , . 666.13 40 3 . 713.40 706,098.80 167,863.38 289,332.80 294.98 163 1 0.00 995,764.37 176,515.96 215,407.74 , , 1,427,688.07 11,734.24 11,734.24 41,504.47 41,504.47 15,999.35 15,999.35 40,268.00 40,268.00 10,426.51 10 426.51 69 , 441 000.69 7.94 , 139 837.94 5.00 , 125.00 7.19 127.19 4.82 $1,827,582.24 $351,127.69 $505,273.18 $3,321,507.93 1.67 $ 221.67 $ 127.19 127.19 1.67 $ 127.19 $ 348.86 7.22 $1,409,906.01 $376,148.29 $505,270.75 $2,893,392.27 11,090.58 , 11,090.58 39,671.88 39,671.88 10,000.00 10,000.00 1,569.00 1,569.00 .93 355,217.58 (25,020.60) 2.43 365,435.34 3.15 $1,827,455.05 $351,127.69 $505,273.18 $3,321,159.07 4.82 $1,827,582.24 $351,127.69 $505,273.18 $3,321,507.93 5 6 1 0 fair 2, 3 Iding et to from u f the the held -2~ -
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THE WEBB-WARING INSTITUTE FOR MEDICAL RESEARCH MAINTENANCE FUND INCOME STATEMENT For The Year Ended June 30, 1970 Exhibit "B" RECEIPTS Contributions: Maintenance Fund - Scedule 6_------------------- $ 51,284.81 interest income _.-_---_---_----___---------------- -----.--------- -- 61,529.53 Dividends ------ _. _-__--------- ------- -_._.---- -_... 50,003.75 Laboratory fees for tests or equipment use ........ ---•_-__-______________ 8,094.05 Misceiianeous income -__-•---. _---------•---.---_-_..-.•-..--_-..----- 893.29 Lincoln Laboratories - grant -0-- Total Receipts ..... __-.___.------------ -.-_-_.-------------- _ EXPENSES Professional meetings ._---------------------- -------- _------------ ....------------------- -$ 283.00 Salaries - administrative _...... -...... -----_-. ......... --_-_-------------- ..-_.- 84,997.88 Salaries - secretaries ------................... --_ ------------------ ___....... ____ 15,541.75 T.I.A.A., P.E.R.A. and group insurance ___------ -------- .......... 5,835.55 Maintenance on building and equipment ----.-_--.-_------ _------------ 3,876.19 Brochure expense _ _ __------ 3,161.45 Miscellaneous expense _ ..... __----- ----- ----- 543.33 Payroll taxes --------_.._.-----------------_ ------•------------------------ 3,612.28 Safekeeping and trust service - First National Bank, Colorado Springs, Colorado w-------------- ---------•-_----. 2,452.87 Denver office expense _ --__----------- ....... -•-•----- ---•--- 2,026.53 Travel expense ------ -.----._ ------------ -_._-__._ 3,594.27 Audit ----------------------------------------- --- -.... .... --------- --------- - 1,000.00 Laundry 837.07 Smaii instruments and supplies 3,097.02 Mimeograph ._._-----_._.----_.._-------------•----------- ............ ----- 1,309.38 Coiorado Springs office expense 453.94 Medical publications _........ _________----- _-------- -_-__-..__.... __ 638.63 Audio-visual expense __.. ......... -._--------- -------- ___--_-_----- 638.25 Telephone ------- ----- --------- ----------------•------------- 269.20 Insurance •------ ----------- ------- ------ ........ -..-_.---------•----- ----------------•- 647.00 A n i m a i s--------- •-------------- •------------- ----------------- - ---- - 232.01 Freight -- ------- -------- ---- - 88.35 Aspen Emphysema Conference ------------------__.._._..-----__------___. 300.00 Legal expense --------- ------------ ----•-------- 93.75 Typewriter pool 178.70 Consultant expense 861.10 $171,805.43 Total Expenses _---.•.._.-------------------------------- ____ -------------- $136,569.50 Net income f IossJ -------------- ------------ -------- ---- --------- ---- $ 35,235.93 *This does not include $1,143.20 spent for equipment, which is included In the balance sheet. -22 - I
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THE WEBB-WARING INSTITUTE FOR MEDICAL RESEARCH BUDGET - 1970 - 1971 APPROVED BUDGET 1970-1971 BUDGET 1969-1970 ACTUAL 1969-1970 RECEIPTS Interest ____ .- .__.________-------- $ 60,000.00 $ 60,000.00 $ 61 529.53 Dividends 50,000.00 40,000.00 , 003.75 50 Laboratory fees for test or equipment use ..__. 5,000.00 6,000.00 , 094.05 8 Miscellaneous other income 1,000.00 1,000.00 , 893.29 Contributions ._.__ 78,646.00 23,798.00 51 284.81 Lincoln Laboratories grant , -0- Total Receipts _._.._______.__$194,646.00 $130,798.00 $171,805.43 DISBURSEMENTS Audit expense 1,000.00 $ 1,000.00 $ 1,000.00 Brochures and annual report ___ 3,600.00 3,600.00 3,161.45 Building maintenance ~ 2,500.00 2,500.00 3,876.19 General insurance _ 600.00 200.00 647.00 Consultant expense-honorarium 1,000.00 700.00 861.10 Education 1,000.00 1,000.00 638.25 Freight express, hauling -0- 50.00 88.35 Grants, reserve, cost sharing: Contingenty reserve for grants 10,000.00 2,000.00 -0-. Cost sharing _ -0- -0- -p_ Laundry 1,000.00 1,000.00 837.07 Library expense __ 800.00 300.00 638.63 Mimeograph and reproductions 1,500.00 1,200.00 1,309.38 Office expense (Denver & Colorado Springs) .__. 2,000.00 1,200.00 2,480.47 Postage and mailing costs r._ 1,600.00 1,200.00 --0-- Salaries and matching funds _- 140,146.00 109,048.00 106,375.18 Supplies: Animals and animal care ~-0- 100.00 232 01 Storeroom (University Catalog) -0- 700.00 . -0-- Small instruments _ --0- --0-- 3,097.02 Safekeeping and trust service _ 2,000.00 1,400.00 2,452.87 Travel expense 2,000.00 1,000.00 3,594.27 Typewriter pool .~. 200.00 200.00 178.70 Telephone tolls 400.00 400.00 269.20 Miscellaneous - other unlisted 1,000.00 1,000.00 1,220.08 Taxes 4 300 00 -0- 3 612 28 , . , . Total oper. disbursements -$176,646.00 $129,798.00 $136,569.50 Capital improvement: Remodel 4th Floor 15,000.00 $ -0- $ -0- Webb building modification --0-- 500.00 -0.- Equipment and furniture 500.00 500.00 2,691.19 Sonicator dishwasher .Y _._ 2,500.00 -0- -0- Total disbursements _____$194,646.00 $130,798.00 $139,260.69 Excess of receipts over disbursements $ 32 544 74 , . -23-
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CONTRIBUTORS TO THE WEBB-WARING INSTITUTE Mrs r M . V/il To those who have shown an interest in our professional programs, encouraged our staff and provided material support in the form of grants, bequests or other contributions, we Mr. send our sincere thanks and warm greetings. We especially wish to thank the following in- dividuals, Public Supported Health Associations, Foundations, and other benefactor organiza. The Mr. tions for their contributions during the fiscal year ending June 30, 1970. Unless the special E/ P purpose of the gift is listed (e.g., memorials, salaries of investigators, research projects, medical Ti education, equipment, or the endowment fund) it was scheduled as part of the Institute main- tenance fund. Mrs Mr. Mr. and Mrs. David M. Abbott Mr. and Mrs. Temple H. Buell Mrs (in memory of Ralph M. Broadhurst) (in memory of Ora H. George) Miss Hazel C. Adshade Mrs. Ruth Scollard Bulkley Mr. (in memory of Fred Stuart) (in memory of Sewell Thomas) Dr. Mr. L. L. Aitken, Jr. Mr. and Ralph L. Burgess Mr. Mr. and Mrs. Philip K. Alexander (in memory of Ruth E. Underwood) Ed Joseph D Allen Mrs Mr and Mrs Mitchell Burns T . . (in memory of Joseph D. Allen) . . . (in memory of Mrs. Velma E. Kem) Mr. Dr. Ivan A. Allred Mrs. Emma Byler and Marie Byler Dr. (in memory of Dr. Dora E. Walker) (in memory of Jacob Schafer) American Metal Climax Foundation, Inc. Mrs. Alexander Campbell Mrs Mrs Arthur S Amilon Mr Joseph E Carroll . . (in memory of Joseph Rosenberg) . . Mrs. David Twiggs Chalmers Mr. Mr L. B Anderson (in memory of Comdr David Twiggs Chalmers) . . (in memory of Louis A. Goalby) . Mai. Gen. and Mrs. Robert D. Charlton Mrs Mis Mr. and Mrs. E. William Andrews (in memory of Clarence H. Adams, Jr.) Mis (in memory of W. Cyrus Wilson) (in memory of Col. Valerius Hakanson) Mr (in memory of Ayres Crews) (in memory of Col. Philip S. Van Cise) . Anonymous (in memory of Dr. James J. Waring) (Maintenance Fund; Endowment Fund; (in memory of Mrs. Clee (Jennie) Fitzgeraldl Dr. James J. Waring Memorial Fund) Mr. and Mrs. Kimberly Cheney Mr. Dr and Mrs William Mathews Bane (in memory of Eric A. Swenson) . . (in memory of James B. Stewart) Dr. Paul M. Clark Goc Mr. and Mrs. Thomas H. Barber (Endowment Fund) (in memory of Ralph B. Moore) Mrs. Lillian Cohen Mr. Dr. Mary Louise Barker (in memory of Janet Marie Pinsky) Mr. (in memory of Paul S. Barker, Sr.) (in memory of Ida Edelson) Mr. and Mrs. Lloyd Barnes (in memory of Julius Leberstein) Mrs (in memory of Jacob Schafer) Colorado Mountain College, East Campus Mrs. Leo L. Beavers (in memory of Robert H. Tracy) Mrs (in memory of Mrs. Mabel Kimball) Colorado Tuberculosis and Respiratory Otto Bendewald Family Disease Association Mrs (in memory of Jacob Schafer) (Education Fund) Harry Benner Family Adolph Coors Company Mre (in memory of Jacob Schafer) Brig. Gen Thomas P. Corwin, USAF (Ret.) Mrs. George Berger, Jr. (in memory of Carl A. Norgren) Mr. (Endowment Fund) Mr. Alfred Cowles Mrs. R. Clifford Black (Endowment Fund) Mr! (Endowment Fund) Mr. Knight C. Cowles N Mr. and Mrs. J. C. Blickensderfer Mrs. J. Wallace Coxhead T (in memory of Ralph M. Broadhurst) (in memory of Woodford A. Matlock) B Mrs. Liddon Blood-Smyth Mr. and Mrs. Kevin C. Croke Boettcher Foundation (in memory of Dr. James Burris Perrin) Mr. (Research Fellowship Fund) (in memory of Nancy Denious) Mr. Mrs. Arthur H. Bosworth and Dr. and Mrs. Ward Darley Mr. Mr. and Mrs. Barry M. Sullivan Mr. and Mrs. Maxwell S. Davidson Mrs. Robert G. Bosworth (in memory of Dr. Gerald B. Webb) Mr. (Maintenance Fund; in memory of (in memory of Mary Day MeLane) Mr. Ralph M. Broadhurst) (in memory of Meriam B. Berger) Mist Mrs. Roderic J. Bosworth (in memory of Dr. and Mrs. Gerald B. Webb) (in memory of Louis A. Goalby) Dr. Charles L. Davis Mrs Mrs. T. Kenneth Boyd Mr. and Mrs. Jefferson Hayes Davis Mr and Mrs William A Boyd (in memory of Dr Gerald B Webb) . . . . . Miss Mrs. A. S. Brodhead Mr. and Mrs. W. W. Dean (in memory of Aurther Sayer Brodhead) Denver Policemen's Protective Association Mrs. John Brooks, Jr. (in memory of Ralph M. Broadhurst) Dr. Mr. and Mrs. David R. C. Brown Dr. and Mrs. David E. Dines M (in memory A. E. Humphreys) (in memory of Eugene Dines) -24-
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TE ouraged our ributions, we Eollowing in- ~r organiza_ : the special scts, medical istitute main- Chalmers) Jr.) on) se) zgerald) ws ) 3. Webb) i Mrs. Eugene Dines and Family (in memory of Douglas Findlay) Mr, and Mrs. Robert Donner, Jr. William H. Donner Foundation (Research Fellowship Fund) Mr. and Mrs. Montgomery Dorsey (in memory of Edward G. Knowles) The John G. Duncan Trust Fund Mr. John Elliott El Paso County and Central Colorado Tuberculosis Association (Educational Research Fellowship Fund) Mrs. Howard Eric Mr. and Mrs. Morris A. Esmiol Mrs. Viola E. Fancher (in memory of Jacob Schafer) Mr. C. Merrill Fanoni Dr. and Mrs. L. J. Farabaugh Mr. George Fayette Ed Fisher Family (in memory of Jacob Schafer) Mr. William M. Flansburg Dr. and Mrs. Carl Flaxer (Margaret Liggett Memorial Fund) Mrs. John F. Gallagher (Endowment Fund) Mr. and Mrs. Walter W. Garnsey (in memory of Mrs. Esther M. Bohannon) Mrs. George H. Garrey Miss Margaret Gebhard Miss Minnie Gebhard Mr. Ralph Owen Giddings, Jr. (in memory of Mrs. John Renzulli) (in memory of Joseph Warden Reid) Mr. and Mrs Elroy F. Goebel, Sr. (in memory of Mrs. Velma E. Kem) Goodwill Auxiliary, Hobby Group (in memory'of Mrs. Carl Stitt) Mr. and Mrs. Joseph B. Gould Mr. William W. Grant (in memory of Ora H. George) Mrs, Alice E. Griggs (in memory of Marshall R. Griggs) Mrs. Mary Louise Grills (in memory of Ralph M. Broadhurst) Mrs. R. H. Halpenny (Endowment Fund) Mrs. Robert W. Halpenny (in memory of Dr. William D. Milleft) Mr. W. H. Halpenny Mrs. LaWanda Harding (Meadow Gold Dairies) with Ken Thompson, Russ Lykins, Bill Struble, ,Tony Sersante, Bert Dragt, Fred Hodapp, Bill Schutz, Bert Hendrickson, Vic Kuxhaus (in memory of Jacob Schafer) Mr. and Mrs. Jene Harper Mr. and Mrs. Mark H. Harrington Mr. and Mrs. J. Ramsay Harris (in memory of Ora H. George) Mr. and Mrs. Richard A. Harris Mr. and Mrs. Sidney G. Haskins Miss Edith M. Henry (in memory of Mr. and Mrs. S. M. Henry) Mrs. Alfred C. Hicks (in memory of Ruth Taylor Erwin) Miss Louise Hildebrandt (in memory of Jacob Schafer) Dr. and Mrs. Peter C. Hoch and Mrs. H. Hoch-VonSalis (in memory of James 8. Stewart] Mr. and Mrs. Josiah G. Holland for the Division of Pulmonary Physiology (in memory of Archibald M. Bell, Jr.) (in memory of Mrs. Clinton E. Seney) Mr. and Mrs. Charles S. Hover (in memory of Dr. James Burris Perrin) Mr. J. B. Howe (in memory of Louis A. Goalby) Mr. and Mrs. James A. Humphreys, Jr. (in memory of Mrs. Lloyd P. Jones) Mr. and Mrs. Harry E. Hutton (in memory of Dr. Gerald B. Webb) Mr. and Mrs. Clarence L. Ireland (in memory of W. Cyrus Wilson) Mr. and Mrs. John W. Irving and Family (in memory of James B. Stewart) (in memory of Edward G. Knowles) Miss Helen Jackson (Endowment Fund) Judge and Mrs. W. S. Jackson (Endowment Fund) Mr. and Mrs. Albert F. Jepson, Jr. (in memory of Howard Rombach) Mr. and Mrs. Harry Johnson (in memory of Jacob Schafer) Mr. Francis Jones (in memory of Dorothy B. Jones) Mr. Lloyd P. Jones (in memory of Dorothy B. Jones) Mrs. Wanden M. Kane Mr. and Mrs. C. Howard Kost Mr. E. G. Keefe (in memory of Ora H. George) Mr. and, Mrs. Dana E. Kepner - (in memory of W. Ralph Johnson) Mr. Kenneth K. King Mr. William J. Kirn Mrs. Baxter Lanius (Dr. James J. Waring Memorial Fund) Mrs. Myrtle Larson (in memory of John E. Larson) Dr. Robert S. Liggett (Margaret Liggetf Memorial Fund) Mr. and Mrs. Eugene Lilly Mr. and Mrs. Joe G. Lind Mrs. John G. Lowe Miss Dorothy M. Lucas (in memory of Mrs. Malfie Langford) Mrs. John Mackenzie (in memory of Ralph M. Broadhurst) Dr. and Mrs. David S. Madison (in memory of Louis A. Goofby) Mrs. Harry A. Marr Dr. William D. McCarthy (in memory. of Dr. Harry Gauss) (in memory of Mrs. Wilbur F. Denious) Mr. and Mrs. T. Verne McCaw (in support of research projects) Mrs. Donald C. McCreery (in memory of Mrs. Daniel R. Higbee) Mr. and Mrs. Douglas McHendrie (in memory of Ora H. George) Mrs. Hugh McLean Meadow Gold Daries (in memory of Jacob Schafer) Dr. and Mrs. William D. Millett (Endowment for Division of Pathology) Mr. and Mrs. Guy P. Million (in memory of Brian D. Million) Mr. and Mrs. Charles Mills (in memory of Jacob Schafer) -25-
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Mr. and Mrs. Marvin Mintz (Endowment Fund) Dr. and Mrs. Robert G. Mitcheltree (Endowment Fund) Mr. and Mrs. Cedric Mittag (in memory of Jacob Schafer) Mr. and Mrs. 1. T. Monseth (in memory of Louis A. Goalby) Miss Fortunee L. Morrison (in memory of Ralph M. Broadhurst) Miles Morton Family (in memory of Jacob Schafer) Mr. and Mrs. Merle F. Moss (in memory of Jacob Schafer) Mr. and Mrs. Gilbert J. Mueller (in memory of Edward G. Knowles) (in memory of Ora H. George) (in memory of Archibald M. Bell, Jr.f Mrs. Theodore Neumann (in memory of E. Irving Hanson, Jr.) Mrs. Henry L. Newman Mr. and Mrs. Aksel Nielsen Maj. Gen. and Mrs. O. K. Niess (in memory of Harry Huffman) (in memory of Gen. Eugene Reinoriz) Carl A. Norgren Foundation Carl A. Norgren Trust Francis S. North Foundation North Central Colorado Health and Tuberculosis Association (Fellowship Fund) Mrs. E. Garrick O'Bryan (in memory of Henry Denison) Mrs. Donald M. Oenslager (Endowment Fund, in honor of Marka Webb Stewart) Mr. and Mrs. Benjamin A. Oxnard General and Mrs. E. E. Partridge Mr. Joseph D. Pepper Mr. and Mrs. C. A. Peterson (in memory of Mrs. A. H. (Mary) Ayres) Dr. and Mrs. Roy A. Phillips (in memory of Mary MeKelvy) (in memory of Evelyn Bond) (in memory of Dr. Roy A. Philiips. Jr.) (in memory of Dr. James Burris Perrin) (in memory of James MeKeivy) Mr. and Mrs. Allan R. Phipps (Endowment Fund, In memory of Henry C. Van Schaack) Mrs. Vincent Charles Pigott, with Blanche L. Calkins, Lila L. Calkins and Flora L. Youmans Mr. and Mrs. Thomas Emerson Proctor Mrs. Paul T. Rhody, for the Kem Family neighbors (in memory of Mrs. Velma E. Kem) Roger Richter Family (in memory of Ralph M. Broadhursf) Mrs. Henry B. Riedeburg (Endowment Fund, In memory of Henry B. Riedeburg) Mrs. William F. Ross (in memory of Jacob Schafer) Mrs. Geerge Lee Sargent pn memory of Mrs. Lloyd P. Jones) Mrs. Norma Saur Family (in memory of Jacob Schafer) Mr. and Mrs. Eari M. Scanlan Dr. and Mrs. Eugene Schulman (in memory of Terry Ruth Bilett) Mrs. Amelia Seader (in memory of Jacob Schafer) John Seader Family (in memory of Jacob Schafer) Mr. Mrs. William Serat Mr. and Mrs. Morrison Shafroth Mr. and Mrs. Samuel S. Sherman, Jr. (in memory of Ora H. George) The Myrtle J. Shore Trust Mrs. Paul E. Shriver (in memory of Paul E. Shriver) (in memory of Martha T. Shepard) Mrs. Reginald Sinclaire Mrs. C. Lee Smith (in memory of Mrs. Lloyd P. Jones) (in memory of Dr. Gerald B. Webb) Mr. and Mrs. Dudley T. Smith Dr. G. Paul Smith and Dr. Lynn A. James Maj. Gen. and Mrs. John F. Smaller (in memory of Mr. and Mrs. William M. Randoi) Mr. and Mrs. Leonard V. Sommer (in memory of Louis A. Goalby) Dr. and Mrs. Robert L. Stearns (in memory of Edward G. Knowles) Mr. and Mrs. Charles S. Sterne John W. Stewart 1952 Trust (Endowment Fund) Mr. and Mrs. John Wolcott Stewart (in memory of Dr. Dumont Clark) (in memory of Mrs. Charles T. Ryder) (in memory of Mrs. James Mclane) (for Division of Pathology) (in memory of Knight C. Cowles) Mr. and Mrs. James E. Stokes (in memory of Ora H. George) Mr. and Mrs. William E. Sweet, Jr. (in memory of Robert E. Williamson) Mr. and Mrs. Thomas E. Taplin Mr. and Mrs. George E. Tarbox (Dorothy Blayney Tarbox and Shirley Anne Tarbox Memorial Fund) Mr. and Mrs. Harry Tarkoff (in memory of Dr. Charles J. Keller) Dr. and 'Mrs. Carl W. Tempel (in memory of Mrs. Ofa Buck) (in memory of Dr. Harry Gauss) (in memory of Colonel Charles F. Howland) Mr. and Mrs. Emmett J. Thurmon (in memory of Velma E. Kem) Dr. Giles D. Toll (in memory of Ora H. George) Mr. and Mrs. Henry W. Toll (Maintenance) (Dr. James 1. Waring Memorial Fund) (in memory of James B. Stewart) (in memory of Mrs. Helen Newbury) (in memory of Etienne Perenyi) (in memory of Heber R. Harper) (in memory ol Dr. Dumont Clark) (in memory of Carl A. Norgren) (in memory of William Tracy Hover) (in memory of Ora H. George) (in memory of Roland F. Maroneyl Dr. Henry Wolcott Toll, Jr. (in memory of Ora H. George) Mrs. Harold H. Tracy and Sons (in memory of Robert H. Tracy) Mrs. Robert H. Tracy, for Neighborhood Friends (in memory of Robert H. Tracy) Mrs. Frank A. Taylor (in memory of Mrs. Carl Stitt) Dr. and Mrs. Warren W. Tucker -26-
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, ard) snes) Nebbl t rrk) Ryder) ane) es) .) amson) f Fund) eilerl :) s F. Howland) 1 I Fund) rrt) wbury) 1) .er) :irk) 1) Hover) ,) 'ney) ,) r1 Mr. and Mrs. Herbert R. Vandemoer (in memory of Mrs. George Marlow) Mr. and Mrs. Albert E. Vatter, Sr. (in memory of Martha H. Storner) (in memory of Mrs. Mathilda Lutter) Mr. Arthur G. Vetter The Elizabeth Firth Wade Endowment Fund fin memory of Mrs. Velma E. Kem) (for endowment) Mrs. A. J. Waring (Dr. James J. Waring Memorial Fund) Mrs. James J. Waring (in memory of James B. Stewart) (in memory of Dr. William D. Millett) (in memory of Arnold B. Gurtler) William Doane Watson Family (in memory of Robert H. Tracy) Rev. Harry Watts (in memory of Clarence W. Gstettenbauer) (tn memory of Dr. Robert W. Gordon and Dr. Aileen Gordon) (in memory of Mrs. Margaret Morris) Mr. and Mrs. Joel A. H. Webb Miss Eleanore M. Weckbaugh (Endowment Fund) Mrs. Stanley A. Welsh (Endowment Fund, in memory of Mr. and Mrs. Samuel L. Shober) Mrs. Edward D. White, Jr. Dr. and Mrs. Richard W. Whitehead Larry Williams Family (in memory of Jacob Schafer) Rev. and Mrs. L. C. Wolcott (Endowment Fund) Mrs. Elizabeth Yager and Miss Mary Johnston (in memory of Ora H. George) Mr. and Mrs. Harry Yost (in memory of Jacob Schafer) Dr. and Mrs. John Zarit (Endowment Fund) -27-
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INFORMATION AND SUGGESTIONS FOR CONTRIBUTIONS If we have not properly listed your name or purpose of your gift, please be kind enough to inform us for future reference. We are anxious to record the purpose of each contribution correctly and to use it as designated by the donor. The following exemplifies how gifts may be scheduled: 1. Living Memorial contributions: A planned annual gift to perpetuate the cherished memory of a loved one or esteemed friend. (See comments below) 2. Memorial contributions as an expression of sympathy to a bereaved family. 3. Salaries of investigators. 4. Support of research projects. 5. Medical education. 6. Medical and scientific equipment. 7. The Endowment Fund, 8. Maintenance and operation: All funds not otherwise designated. Though the Institute works closely with the University of Colorado Medical School, it is a private, non tax-supported institution, dependent to a large extent upon private contribu- tions and upon income from its own Endowment fund, built up through the years by individuals wishing to support research to improve health and save lives. It has become a most appropriate expression of sympathy to the bereaved family to make a memorial contribution to the Institute in the name of the deceased. When such con- tributions are received, the family is always advised of the gift. It should be noted that "Living Memorials" are planned annual gifts to perpetuate the cherished memory of loved ones or esteemed friends and recognizes the fact that many years will be required in the eventual conquest of certain respiratory diseases. These annual contributions may be changed or dis- continued when circumstances make this desirable. Please make checks payable to The Webb-Waring Institute for Medical Research. Gifts of securities provide distinct tax advantages to the donor and should be sent unendorsed with a stock power endorsed in blank and sent under separate cover. Gifts are deductible as provided by law. They may be addressed to the Secretary-Treasurer, the Webb-Waring Institute for Medical Research, 418 First National Bank Building, Colorado Springs, Colorado, 80902, or to our Denver address. Bequests to the Institute are exempt also from Federal and State inheritance and Estate taxes. The following form can be used for making such bequests by will: "I give and bequeath to THE WEBB-WARING fNSTITUTE FOR MEDICAL RESEARCH, a non-profit corporation under the laws of Colorado, the sum of $ .-_ _ __ -._.._..___-. (or describe property). ~ c s P Pi a; ts C iC( sis Hc 1 9, Ho We to Coi Me, Phy: Edu R 1907 M.D 1931 Yard Medi Corp atorii eiate 1953-1 Assist, Vernro fessor 1967, Fellow Ametic Americ Chest the N Associc Medicc Health, Plannin munico Membe Associc totogic lYlK setts, , sitx of versity Ridge Feilow, (Genef Associ, ant Pt 1966l physio sistant Reseal Webb• presen -28-
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fIONS kind enough i contribution >w gifts may le cherished I School, it te contribu- , individuals d family to isuch con- that "Living td ones or te eventual led or dis- arch. Gifts forsed with iuctib(e as 'ng Institute do, 80902, and Estate 7AL of 'tyJ. BIOGRAPHICAL NOTES OF STAFF MEMBERS Robert S. Liggett, M.D. Born: St. Louis, Missouri, November 21, 1903; L.A.S., University of Illinois, 1923, St. Louis University, 1929; D.D.S., Washington Uni- versity School of Dentistry, 1928; M.D., Washington University School of Medicine, 1933; Intern, Colorado General Hospital, 1922-1923; Medical Residency, Colorado General Hospital 1934-1935; O.P.D. Res- idency, Colorado General Hospital, 1935-1939; As- sistant in Interna! Medicine, 1939-1942, Assistant Professor of Internal Medicine, 1945-1946, Associate Professor of Internal Medicine 1946-1949, Professor and Acting Head of Department of Internal Medicine, 1949-1950, Assistant Dean, 1945-1950, University of Colorado School of Medicine; Assistant Chief, Med- ical Service, 29th General Hospital, 1942-1944; As- sistant Chief, Medical Service, Fitzsimons General Hospital 1944-1945; Private Practice (Internal Medicine) 1950-1964; Director Medical Education, St. Luke's Hospital, 1964 to date; President Board of Trustees, Webb-Waring Institute for Medical Research, 1969 to date; Member, Denver Medical Society; Member, Colorado State Medical Society; Member, American Medical Association; Fellow, American College of Physicians; Member, Association of Hospital Medical Education. Rog.r S. Mitehell, M.D. Born: September 26, 1907, Wayne, Pennsylvania; B.A., Harvard, 1930; M.D., Harvard, 1934; Intern, Boston City Hospital, 1934-1936j Assistant, Department of Neurology, Har- vard Medical School, 1936; Private Practice (Internal Medicine) Glens Falls, New York, 1937-1942, Medical Corps, AUS, 1942-1945; Resident, North Carolina San- atorium. McCain, North Carolina, 1945-1946; Asso- ciate Medical Director, 1947-1953; Clinical Director, 1953-1954, Trudeau Sanatorium. Trudeau, New York; Assistant Clinical Professor of Medicine, University of Vermont Medical School, 1950-1954; Associate Pro- fessor of Medicine, 1955-1967, Professor of Medicine, 1967, University of Colorado School of Medicine; Fellow American College of Physicians, Diplomate, American Board of Internal Medicine; Ex-President American Thoracic Society; Fellow American College Chest Physicians; Member, Board of Directors of the National Tuberculosis and Respiratory Disease Association. Member, Colorado State Board of Medical Examiners; Member, Council on Public Health, and Committee on Comprehensive Health Planning, Colorado Medical Societyj Member, Com- munications Committee, Denver Medical Society; Member, Board of Directors, Colorado TB and RD Association; Member, American Clinical and Clima- tological Association. M. L Morse, Ph.D. Born: Hopkington, Massachu- setts, February 23, 1921. B.S. (Bacteriology) Univer- sity of New Hampshire, 1944; M.S. (Bacteriology) Uni- versity of Kentucky, 1947; Radiation Research, Oak Ridge National Laboratory, 1947-1951; Predoctoral Fellow, National Science Foundatlon, 1954; Ph.D. (Genetics) University of Wisconsin, 1955; Research Associate, University of Wisconsin, 1955-1956; Assist- ant Professor, 1956-1960, Assocfate Professor, 1960- 1966, Professor, 1966 - present, Department of Bio- physics. University of Colorado Medical Center; As- sistant Director, Webb-Waring Institute for Medical Research, 1959-present; Head, Division of Genetics, Webb-Waring Institute for Medical Research, 1958 - present; Holder of James J. Waring Chair of Biology, Webb-Waring Institute for Medical Research, 1960- present; Career Development Awardee, U. S. Public Health Service, 1961 - present; Foreign Research and Study at the Institut de Biologie Moleculaire, Univer- sit6 de GenbvB, Geneva, Switzerland, 1962-1963; Ed- itorial Board, Journal of Bacteriologyj Consultant, Fitzsimons General Hospital (Army Medical Research and Nutrition Laboratory) 1960-present. President, Rocky Mountain Branch, American Society for Micro- biology, 1967; National Councilor-elect, 1967-1968. Chairman, Committee on Seminars, University of Colo- rado Medical Center, 1966 to present. Member, Editorial Board, Journal of Bacteriology, 1967-1969, reappointed 1970. Member, All University Council in the Biological Sciences, 1968. Subcommittee Member of the American Society for Microbiology on Micro- coccoceae. Giles F. Fiiley, M.D. Borne April 30, 1915, New York City; M.D., Johns Hopkins Medical School, Boi- timore, Maryland, 1942; Intern, 1942-1943; Assistant Physician in Out-Patient Department, 1944-1945; In- structor in Medicine, 1945-1946, all at Johns Hapkins Hospital, Baltimore; Assistant Resident Physician. Barnes Hospital, St. Louis, Missouri, 1946-1947j Asso- ciate Physiologist, The Trudeau Foundation, Saranac Lake, New York, 1947-1953; Director, Department of Physiology, Trudeau-Saronac Institute, Saranac Lake, New York, 1953-1955, Assistant Professor 1955-1958; Clinical Physiologist, Webb-Waring Institute for Med- ical Research, 1955 - present. Associate Professor of Medicine, University of Colorado School of Medicine. 1959-1969; Fellow American College of Physicians, Diplomate American Board of Internal Medicine. Member of American Clinical & Climatological Asso- ciation, American Physiological Society, American Trudeau Society, Colorado Tuberculosis Association, Feliow, American College of Physicians, Western As- sociation of Physicians. Professor of Medicine, Uni- versity of Colorado School of Medicine, 1969. Alfred J. Crowl., Ph.D. Bomr Mexico, D. F., Mexico, April 15, 1930. A.B. (Biological Sciences) San Jose State College, 1951. National Tuberculosis Association Medical Research F®Ilow, 1953. Ph.D. (Microbiology) Stanford University, 1954. National Tuberculosis Association Postdoctoral Medical Re- search Fellow, 1954. Nationat Academy of Sciences- National Research Council Postdoctorat Medical Re- search Fetiow, 1955. Research Microbiologist, Webb- Waring Institute for Medical Research, 1956-1959. In- structor, University of Colorado Medical Center, De- partment of Microbiology, 1956-1959. Head, Division of Immunology. Webb-Waring Institute for Medical Research, 1959 - present. Assistant Professor, Depart- ment of Microbiology, University of Colorado Medi- cal Center, 1959-1965. James Alexander Miller Tuber- culosis Research Fellow, New York Tuberculosis and Health Association, 1959. Associate Professor, De- partment of Microbiology, University of Colorado Medical Center, 1965 - present. Holder of the Robert Donner Chair for Medical Research, Webb-Waring Institute for Medical Research, 1965 - present. Osocr K. Refss, Ph.D. Born, Bad-Duerkheim, Ger- many, May 6, 1921; Naturalized, Anniston, Alabama, August, 1944; Graduate In Animal Husbandry, Na- tional Agricultural College, Pennsyfvania, 1937-1940; U. S. Army, 1944-1947j B.S., University of Chicago. 1950; Ph.D., University of Chicago, 1954; Instnrctor in -29-
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i Chemistry, George Williams College, Chicago, Ill- inois, 1953-1954; Post-Doctoral Fellow, American Heart Association and Research Associate, Department of Medicine, University of Chicago, 1954-1955; Post-Doc- toral Fellow, American Heart Association and Fellow, Department of Physiological Chemistry, The Johns Hopkins University School of Medicine, 1955-1957; In- structor in Physiological Chemistry, The Johns Hopkins University School of Medicine, 1957-1958, Assistant Professor of Physiological Chemistry, The Johns Hop- kins University School of Medicine, 1958-1959; As- sociate Professor of Biochemistry, University of Colorado School of Medicine, 1967 to present. Consultant for Air Sanitation and Industrial Hygiene, California State Board of Public Health. Albert L. Vafter, Ph.D. Born: Chicago, Illinois, November 6, 1921. B.S. (Botany) Northwestern Uni- versity, 1946; M.S. (Botany) University of Illinois, 1953; Ph.D. (Botany, minor in virology and analytical chem.) 1955; Member 1941-42 Chicago Natural History Mu- seum Botanical Expedition to Guatemalat Biologist, Chicago Division of Water Purification, 1946-49t Re- search Electron Microscopist, University of Illinois, 1955-58; Research Electron Microscopist, Abbott Lab- oratories, 1958-61; Associate Professor, University of Colorado School of Medicine, Dept. of Pathology, 1962 - present. John C. Maiset, M.D. Born: Brooklyn, New York, December 31, 1931. B.S., Union College, 1953; M.D., Albany Medical College, Albany, New York, 1957; Intern, Colorado General and Presbyterian Hospitals, 1957-58; Fellow in Pediatric Virology, University of Colorado Medical Center, 1958-60; Medical Corps, U. S. Navy (Epidemiology of Respiratory Infections), 1960-62; Resident in Pathology and Instructor, Dept. Pathology, University of Colorado Medical Center, 1962-65; Faculty Fellow, Department Molecular, Cellu- lar and Developmental Biology, University of Colorado Medical Center, 1969-70. Assistant Professor, Path- ology, Webb-Waring Institute for Medical Research, 1966 to present. Certificate, Anatomic Pathology, American Board of Pathology, 1967. D. Boyd Bigelow, M.D. Born: May 25, 1929, Ed- monds, Washington. Attended University of Washing- ton, 1947-1948; Juiiiiard School, New York, 1948-1950; University of Long Island, 1951 (USAF 1950-1953); University of Colorado, Boulder, 1955-1957; M.D., University of Colorado School of Medicine, 1961. Intern, Colorado General Hospital, Denver, Colorado, 1961-1962. Fellow, USPHS Research Training (Pul- monary Physiology) 1958-1960; Fellow, Internal Med- icine, Sansum Clinic, Santa Barbara Cottage Hospital, 1962-1964; Fellow, American Thoracic Society-National Tuberculosis Association Pulmonary Disease Fellowship, University of Colorado Medical Center, 1964-1966; Assistant in Medicine, 1964, Instructor in Medicine, 1967, Assistant Professor of Medicine, 1968, University of Colorado Medical Center; Research Associate, The Webb-Waring Institute for Medical Research, 1966-t Chief, Pulmonary Disease Service and Direc- tor, Respiratory Care Unit, Denver General Hospital, July, 1968-June 1970. Awards and Honors: Alpha Omega Aipha Honor Society; Roche Award, 1961; Denver Medical Society Auxiliary Award, 1961. Mem- ber, American Thoracic Society, Alpha Omega Alpha Society, Colorado Trudeau Society, Denver Medical Society, Colorado Medical Society, American Medical Association. Thomas L. Petty, M.D. Born: December 24, 1932, Boulder, Colorado. B.A., University of Colorado, 1955; M.D., University of Colorado School of Medi- cine, 1958. Intern, Philadelphia General Hospital, 1958-1959. Assistant Resident In Medicine, University of Michigan, 1959-1960; Junior and Senior Resident in Medicine, University of Colorado Medical Center, 1960-1962. Research Feliow in Pulmonary Disease, University of Colorado School of Medicine, and Webb-Waring Institute for Medical Research, July 1, 1962-July 1, 1963. Instructor of Medicine 1962-1964, Assistant Professor 1964-1968, and Associate Professor University of Colorado Medical Center July 1968 to present. Coordinator of Medical Services, University of Colorado School of Medicine, July 1, 1963-1964. Diplomate of American Board of Internal Medicine and Pulmonary Disease Subspecialty Board. Thomas N. Vincent, M.D. Born: February 21, 1931; B.A., Princeton University, 1952; M.D., Univer- sity of Colorado School of Medicine, 1959; Intern, Walter Reed General Hospital, 1959-1960; Resident, University of Colorado Medical Center, Washington University School of Medicine, and Barnes Hospital, St. Louis, Missouri, 1960-1963; Assistant in Pathology, University of Colorado School of Medicine, 1961-1963; Assistant in Pathology, Washington University School of Medicine, 1963-1964; Instructor in Pathology, 1964- 1965, Assistant Professor of Pathology, 1965-1966, Clinical Assistant Professor of Pathology, University of Colorado School of Medicine, 1966 to date; Active Staff, Mercy Hospital, 1966 to date; Consultant, Clinical Pathology, Veterans Administration Hospital, Denver, 1969 to date; Member, College American Pathologists; Member, American Society of Clinical Pathologists; Member, Colorado Society of Clinical Pathologists; Member, Denver and Colorado Medical Societies; Member, Sigma XI; Member, Alpha Omega Alpha. Ray E. Stanford, M.D. Born, December 4, 1939, Son Diego, California; B.S., Stanford University, 1962; M.D. University of California (Los Angeles), 1966; Resident In Pathology, University of Colorado Med- ical Center, 1966-1969t Instructor in Pathology, Uni- versity of Colorado Medical Center, 1969-1970; Con- sultant in Pathology, The Webb-Waring Institute for Medical Research, 1968-1970. Helvise G. Morse, Ph.D. Born September 17, 1925, Frederick, Maryland. B.A., Hood College, 1946; M.S., University of Kentucky, 1949; Ph.D., University of Colorado, 1966. Research Fellow in Biophysics, 1966- 1967, and Instructor in Biophysics, 1967 to date, Uni- versity of Colorado Medical Center. Joyce K. Newman, Ph.D. Bom: Atlantic City, New Jersey, 1927. B.A., Cornell University, Ithaca, New York, 1948. Ph.D., Biochemistry, University of Chicago, 1955. Research Fellow, Webb-Waring 1n- stitute for Medical Research, 1963-1964 and Research Associate 1964 to date. Wolfgang Hengstenbsrg, Ph.D. Bom February 1, 1939, Mannheim, Germany. B.S. (Chemistry), 1961; M.S. (Organic Chemistry), 1963; and Ph.D. tCarbohy drate Chemistry), 1966, University of Freiburg, Ger- many. Research Associate, Webb-Waring Institute for Medical Research, 1966-1967r instructor in Bio- physics, University of Colorado Medical Center, 1968 to dote. -30-
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mber 24, 1932, of Colorado, :hesol of Medi- v>mmt Hospital, d've, University nor Resident in exficai Center, ry Disease, uledicine, and search, July 1, dne 1962-1964, eiate Professor -v July 1968 to ces, University 1, 1963-1964. tmal • Medicine 3aard. February 21, M.D., Univer- 1959; Intern, 6960; Resident, w, Washington cmes Hospital, in Pathology, me, 1961-1963; iversity School sthology, 1964- 3y, 1965-1966, agy, University 966 to dote; te; Consultant, rtion Hospital, ege American ty of Clinical ty of Clinical xrado Medical Alpha Omega snber 4, 1939, niversity, 1962; ngeles), 1966; olorado Med- athology, Uni- 369-1970; Con- g institute for ieptember 17, College, 1946; , University of )physics, 1966- to date, Uni- Attantic City, ersity, Ithaca, . University of ~)b-Waring In- and Research -n Febnuary 1, :mistry), 1961; .D. (Carbohy- :reiburg, Ger 3ring Institute vctor in Bio- ' Center, 1968 Carl W. Tempel, M.D., Major General, USA (Ret.) Born: July 22, 1903, Canton, Missouri; B.S. 1924 and M.D. 1929, St. Louis University; Intern, Wm. Beaumont General Hospital, 1929; Medical Corps, U. S. Army, 1929-1962, with last assignment Commanding General Fitzsimons Army Hospital; Volunteer Staff, University of Colorado Medical School, 1947 to date; Clinical Professor of Medicine Emeritus 1969; Member Amer- ican Medical Association and Colorado Medical Society; Fellow American College of Chest Physicians; Member Association of Military Surgeons; Member American Thoracic Society; Member Colorado Tuber- culosis Association; Consultant in Tuberculosis, Colo- rado State Health Department; Member, Colorado Interagency Committee on Smoking and Health; Secretary, Colorado Interagency TB Control Council; Diplomate, American Board of Internal Medicine and Pulmonary Diseases; Voluntary Staff Webb-Waring Institute 1970. Edward Byrne-Quinn, M.B. Born: March 2, 1936, Bilston, Staffordshire, England. Trinity College, Cambridge, England, 1954-1957, B.A.; St. Thomas' Hospital, London, England, 1957-1960, M.B.; ap- pointments in hospitals in England 1960-1968; Research Fellow and Assistant in Medicine, Cardiovascular Pulmonary Research Laboratory, University of Colo- rado School of Medicine, 1968-; Research Associate, The Webb-Waring Institute for Medical Research, 1968-. Member, The Royal College of Physicians; Fellow, The Royal Society of Medicine, London, England. John V. Weif, M. D. Born: May 10, 1935, De- troit, Michigan. Yale University, 1957, B.S.; Yale School of Medicine, 1958-1961, M.D. Yale-New Haven Hospital, 1961-1968. Research Fellow, University of Colorado School of Medicine, 1966-1967. Military Service: Surgeon, USPHS., Heart Disease Control Program - Colorado State Health Department and High Altitude Research Unit, University of Colorado Medical School, 1964-1966. Clinical Associate in Medicine and Attending Physician, Chest Clinic, 1964- 1966; Assistant Professor of Medicine, University of Colorado School of Medicine, 1968-. Honors: Alpha Omega Alpha. Research Associate, The Webb-Waring Institute for Medical Research, 1969-. BIOGRAPHICAL NOTES OF RESEARCH FELLOWS Bruce A. Brian, M.D. Born: March 17, 1939, Baltimore, Md., B.A., Williams College, Williamstown, Mass., 1961; M.D., University of Maryland School of Medicine, 1965; Intern, University Hospital, Baltimore, Md., 1965-1966; Junior Assistant Medical Resident, Vanderbilt University Hospital, 1966-1968; Fellow, Middle Tennessee Heart Association in Cardiopul- monary Diseases, Vanderbilt University Hospital and Instructor, Department of Medicine, Vanderbilt Uni- versity School of Medicine, 1968-1969; Fellow in Pulmonary Diseases, University of Colorado Medical Center and The Webb-Waring Institute for Medical Research, 1969-1970. Buff B. Burtis, Jr. Born= June 29, 1936, Clinton, Oklahoma. B.A., University of Oklahoma, 1959; M.D., University of Oklahoma School of Medicine, 1964; Internship and Residency in internal Medicine, Denver General Hospital, 1964-1967; Lieutenant Commander, MC, USNR, stationed in San Diego; Fellow in Pul- monary Disease, University of Colorado Medical Center and Webb-Waring Institute for Medical Re- search, 1969-1970. David Char, M.D. Born: July 30, 1937, Canton, China; B.A., Haverford College, Haverford, Pa., 1959; M.D., Johns Hopkins University School of Medicine, Baltimore, Md., 1963; Intern and First-year Assistant Resident in Internal Medicine, Barnes Hospital, St. Louis, Mo., 1963-1965; Tuberculosis Branch, USPHS, assigned to New York City Department of Health, 1965-1967; Second-year Assistant Resident in Internal Medicine, University of Washington, Seattle, Washing- ton, 1967-1968; Fellow in Pulmonary Diseases, Webb- Waring Institute for Medical Research and Assistant in Medicine, University of Colorado Medical Center, 1968-1970; North Foundation Senior Fellow in Pui- monary Diseases, 1969-1970. V. Alton Dohner, M.D. Born: June 5, 1934, Las Vegas, New Mexico. Undergraduate training, Uni- versity of New Mexico, 1952-1956 and University of Tulsa, 1958-1960; U. S. Army Medical Service School, January-March, 1957; B.S. Zoology January, 1960, University of Tulsa; University of New Mexico, M.S., Physiology 1960-1961; University of Colorado School of Medicine, M.D., 1961-1965; Internship, U. S. Public Health Service Hospital, Seattle, 1965-1966; Residency in Internal Medicine, U. S. Public Health Service Hospital, Seattle, 1966-1968; Postdoctoral fel- low in Pulmonary Disease, Webb-Waring institute for Medical Research and Assistant in Medicine, Univer- sity of Colorado Medical Center, 1968-1970. Mem- berships: American Medical Association, Colorado Medical Society; Denver Medical Society; American Thoracic Society; American Association for the Ad- vancement of Science; American Institute of Biological Sciences; Commissioned Officers Association of the U.S. Public Health Service; Clinical Society of the U.S. Public Health Service. Enrique Fernandez, M.D. Born: July 10, 1936, Valparaiso, Chile, S.A.; M.D., University of Chile School of Medicine, 1960; Internship, 1960; Fellow and Resident in Internal Medicine, San Borja General Hospital, University of Chile, 1961-1963 Assistant Professor, Pneumothisiology, University of Chile, 1966- 1969. Fellow, American College of Physicians in Chest Diseases, University of Colorado Medical Center, 1969-1971. Yutaka Fujita, M.D. Born May 11, 1930, Toyamo City, Japan. M.D., Osaka University School of Med- icine, 1954; internship, Toyama Central Hospital, 1954-1955; Research Associate, Tuberculosis Research Institute, Kyoto University, Kyoto, Japan, 1955-1964 and 1965-1967; Research Fellow, Department of Micro- biology, University of Colorado Medical Center, 1964-1965r Postdoctoral Fellow, Webb-Waring Institute for Medical Research, September 1967 to 1969. George A. Griggs, M.D. Born: July 24, 1932, Pueblo, Colorado; B.A., University of Delaware, 1954; M.D., Jefferson Medical College, Philadelphia, 1958; Intern, Delaware Hospital, Wilmington, Delaware, 1958-1959; General Medical Officer, U.S. Air Force, in Europe and Andrews Air Force Base Hospital, 1959-1963; Resident in Internal Medicine, Walter Reed -31 -
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Army Medical Center, 1963-1966; 10 month course Military Medicine and Allied Sciences, Walter Reed Army Institute of Research, 1967; Chief, Internal Medicine Department, USAF Academy Hospital, 1967- 1969; Fellow in Pulmonary Diseases, Webb-Waring Institute for Medical Research and Assistant in Med- icine, University of Colorado Medical Center, 1969- 1970. Keith Horsfteld, M.D. Bom: May 5, 1933, Ac- crington, England. M.B., Manchester University Med- ical School, 1956. House Surgeon, Manchester Royal infirmary, 1957. House Physician and Senior House Officer, Blackburn Royal Infirmary, 1957-58. Senior House Officer and Medical Registrar, Bury and Ross- endale Hospital Group, 1959-61. Member of Royal College of Physicians of London, 1961. Medical Reg- istrar and Senior Research Fellow, Queen Elizabeth Hospital, Birmingham, 1962-66. Lecturer in Medicine, University of Birmingham, 1966 to present. Doctorate thesis (with honours and the Leonard Barrows Prize), University of Birmingham, 1967. Fellow in Pulmonary Disease, Webb-Waring Institute for Medical Re- search, and Assistant in Medicine, University of Co- lorado Medical Center, 1968-69. Yaldemar A. Y. Lindquist, M.B., B.S. ,Born: De- cember 3, 1938, Kuala Lumpur, Malaysia. M.B., B.S., Middlesex Hospital Medical School, University of London, 1963; Member of Royal College of Physicians (England), 1968; Internship in General Surgery and General Medicine, Royal Hampshire County Hospital, Winchester, and Gloucester Royal Hospital, 1963-1964; Junior Medical Resident, Royal Devon and Exeter Hospital, 1964-1965; Resident in Chest Medicine, St. John's Hospital, London, S.W. 11, 1966; Medical Resident, St. Stephen's Hospital, London, S.W. 10, 1967-1969; Fellow in Pulmonary Disease, University of Colorado Medical Center and Webb-Waring Institute for Medical Research, 1969-1970. Karen H. O'Hare, Ph.D. Born: February 10, 1943, Williston Park, New York; B.S. (Biology) St. Lawrence University., 1964; predoctoral fellow, National In- stitutes of Health 1964-1968, Ph.D. (Anatomy) Univer- sity of Rochester 1968. Postdoctoral research fellow Department of Pathology (University of Colorado School of Medicine) and The Webb-Waring Institute for Medical Research (Cell Biology) 1968 to present. Member Rocky Mountain Society for Electron Micro- scopists. Donald B. Olsen, D.Y.M. Born: April 2, 1930, Bingham, Utah; Education: Animal Nutrition and Chemistry, Utah State University, Logan, Utah Sept. 1949 - March 1952; School of Veterinary Medicine, Colorado State University, Fort Collins, Colorado Sept. 1952 - June 1956; B.S. Degree June 1953, D.V.M. Degree June 1956; Graduate School University of Nevada, Reno, Nevada Sept. 1966 - March 1968; Graduate School University of Colorado School of Medicine, Denver, Colorado Sept. 1968 - Present. Experience: Private practice Veterinary Medicine, Smithfield, Utah 1956-1963; Assistant Professor of Veterinary Science, University of Nevada, Reno, Nevada 1963-1965; Biomedical Research Veterinarian, Patho-Physiology Laboratory, Desert Research Institute, University of Nevada, Reno, Nevada 1965-1968; Special Post-doctoral Fellowship (National Heart In- stitute) Department of Pathology and The Webb- Waring Institute 1968-Present. Affiliated with Drs. Vatter and Reiss. Member American Veterinary Med- ical Association, National Society for Medical Re- search, American Association for the Advancement of Science, American Society of Animal Science, and American Association of Laboratory Animal Science. W. Peter Petersan, M.D. Born: September 26, 1937, Jamestown, New York. B.S., Allegheny College, Meadvilte, Pa., Cum laude, 1959; M.D., Harvard Medical School, 1963; Assistant in Pathology, Peter Bent Brigham Hospital, 1963-1964; Intern and Resident in Internal Medicine, Cleveland Metropolitan General Hospital, 1964-1967; U.S. Army, Major, MC, stationed Fort Riley, Kansas and 17th Field Hospital, AnKhe, Viet Nam, 1967-1969; Fellow in Pulmonary Disease, University of Colorado Medical Center and Webb- Waring Institute for Medical Research, 1969-1970. David S. Terman, M.D. Born: October 23, 1940, New York, New York. B.A., Syracuse University, 1962, M.D. Georgetown University School of Medicine, 1966; Intern and Assistant Resident, University of Alabama Medical Center, Birmingham, 1966-1968; Fellow in Nephrology, University of Colorado Medical Center, 1968-1969, Fellow in Immunology, University of Colo- rado Medical Center, 1969 to date.
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