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i THE ARTERIAL WALL -1 Azalea Room LIPOPROTEIN STRUCTURE Camellia Room Chairpersons Ch,airpersonc M. Oaria Haust Kenneth M. Walton H. Bryan Brewer Wifhelm Stoffel M. Daria Haust Coiirt J. Schwartz Abet Robertson ack t.. Titus Elspeth B. Smith Participants tntroducfion Uitrastructure on Normal Arterial t:ndofhelium Arterial EndOthelium In lnitial Stages of Atherogenesis Smooth Muscle Cells in i Atherosclerosis 0iochemical Studies on Permeability and /nteraction Between 81ood Constituents and Arterial Components in Atherosclerosis Discussants Participants German Camejo The Associating System of Smell Subunits in Apo LOL Richard L. Jackson Lipoprolein Structure-and;he Mechanism of Action -0t _ Lipoprotein Lipase Gerhard M. Kostner StructureofHighDensityL-ipoprofeins Joel D. Morrisett Structu ! S ra hedies o/ Cholesterylester- Rich Very L ow Density Lipoproteins (CER-VLDL) G. Graham Shipley Wiihef ~ m Stoftet Topochemical Studies on Human Serum High Density Lfpoprotein r~} ~! £y~~ ~C- F Colin W. M. Adams Scren Bojorerud CONCURRENT ORAL PRESENTA Lesie Robert TIONS 4:00 - 6:30 p.m. Kenneth M. Walton Summing-Up ANIMAL MODELS OF A THER . OSCLEROSiS - I LIPID, APOPROTEIN AND LIPOPROTEIN , ORIGIN AND SYNTHESIS Bluebonnet Room Chairpersons Richard J. Havel Barry Lewis i Shtomo Eisenberg Participants The Origin in Plasma of Low Density and High Density Lipoproteins Godfrey S. Gett 8iosynthesis of Rat Lipoprotein E Roltert M. Glickman Apoproteirf Searetion from Human lntestine Robert L Hamilton David B. Weinstein Embassy Room Chairpersons Douglas A. Eggen Jan Author Rapacz_ Title 2 Mu"Iler, Klaus R. Geneticatl H . lemic Rafs as Animals tor Hypolipidemic Drugs. 3 Kramsch. Dieter M. The Role ot Calcium in 4 Aschenbrener. Carol r. I terolemic Diet on Two-Kidney ~ (3o1db/atf Rabbifs. Atherogenesis-srrd-ita Suppression by Calcium lnhibitors in Primatbs. Effects or a Hypercho:es_ 1

r", 5 Keifey Jim L --•~ I The Turkey as a Modal for i , . Atherosclerosis: Quantifica- 1 tion of Plasma and Arterial ~ 6 eRey. Jim L. f Apolipoproteins by Eiectroimmunoassay. - Effect of Dietary Cholesterol [ on Plasma and Arterial Lipo- proteins in rhe Turkey. s 7 McTaggart. Fergus investigation of the Common [ Marmoset as an Animal 8 emura. Eliichi r Model for Lipoprotein Research. Experimental Atherosclerosis ~ 9 Mills. Gervase L Produced by Simple Sugar I Feeding. Induction of Hyperlipaeinia in - 10 Mills. Gervase t.. Gc inea Pigs. Serum Lipoproteins ol i Sturgeon. ~ EP1®EbV®LOGY I - ~ ~ Marco Poto Room Chairpersons Nemat Borhani David Brunner AbWWp 11 First Author Kupke, Ingeborg. R. Title Metabolic Factors Associated 2 Wallentin. Lars C. with Atherosclerosis. - Exami- nation of Young Children In Duesseldorf. Lipoprotein Lipids in ~. 13 applt. Jan J. Coronary Atheromatosis rnterrelationship Between 4 rank, Gall C. Ultracentrifugal and Electro- phoretic Patterns of Plasma Lipoproteins and Topogra- phy of the Pre-Al Cornpiex. The Relationship of Jntant Feeding Patterns to Coronary Risk Factor Variables in the First Year of Life. 15 Schneider, JOrgen Ather I os 16 tCutsumi, Yasunori '17 L~larriq, Jean 18 ®erchtoid, Peter 19 Hatano. Shuichi c erobc Comprica. J tions in Octo- and Non. agenarians Related to Hiyh- Density_Lipoprotein -Cho/esterol. Ethnica/ Dillerence o/ Plasma Llpoprotein Concentratfon in Adult and Umbilical Cord Blood.• Higher Levo10l plesnraHigh Density Lipoprotein (HDL) in Japanese. An Epideiniologicat Research . ol Ath erosclei ross Among Patients Presenting Vascular Risk Factor Without Any Clinical Vascular Symptom. High Densit y L fpopro tein- Cholesterol and Coronary Risk F ectors in Ob ese Patienrs. Trends o1lschenric H eart D sease Mtl 'oraity and Possible Risk Factors in Japan. 20 Angelico, Francesco The Rome Pro Coronary HABrr Disease Prevention: Evaiuation f o Ly,etary ChangesAltera Four- Ypar Intervention. ®RUG ErFECTS Ip ANIMALS -1 Grove Room Chairpersons Howard Eder Alan N. Howard First Author 21 _ Cayen, Mitchell N. r F V Title ~ Bspecrs oJ Serum Protein ` i ndmg of Clclibric Acid in Normal mw n..,-___. - -

1 22 thn Harry Y. C. Wong e r pn f l Abwftaip First Author Title . iDL Valrum O Etlecf ol 31 Uoneda. Genju Smooth Muscle Cells in the 3 Cholesterol Jri Atherogenic- Fed Roosters. Wu. Chun-Churg Mechanisms of Cholesterol Development of Atheroscle- rosis and Arterionecrosis of the Intracerebra/ Arteries. Lowering Effect uf Acupunc- 32 Reiniia. Aiti Accumulation of Lipid in 4 ture in Rabbits: A Plasma Factor. _ Langner. Ronaid O. Relationship of Tissue Muscular Arteries of Short- Term Diabetic Rats: Electron Microscope Study. Protein Synthesis to 33 Makita. Takashi Fine Structure of Elastic r Cholesterol Accumulation in Different Tissues of the Rabbit. Layers and Other Features ofg lntima/ Smooth Muscle Cell - Masses in the Abdominal 25 Jett. Charlene M. Shift in Guinea Pig Lipo- Aorta of Swine. protein Profiles Induced by 34 Newton, Sheila A. Characteristics of the 5= 6 aikonen. Marjatta Modulation of HMG CoA Reduc.tase Activity. Paradozical Altera.rC ns d b t Nucleotidase Activity of Swine Arterial Smooth Muscle. e Lipoprote+n Ltp+ds aus y 35 Morisaki. Nobuhiro Lipid Metaboliam in Aorta and Gemfibrozil. Clofibrate and Nicotinic Acid. 6 Brain Microvessels. Largis, Elwood E. E/lects of Cetaben Sodium 27 Fears. Robin B. The Effect of Compactin on Chotesterogenesis and Serum Cholesterot in Ftats and Chicks. 7 on Lipid Metabolism in Aortic Smooth Muscle Cells in Tissue Culture. Crass. Maurice F. Effects of Insulin and 28 Cheng. Davy C. H. Norethindrone Acetate Norepinephrine on Glucose 9 hessebeuf. Nadme L Inhibition of Hepatic Triglyc- erids Synthesis in Isolated Rat tiepatocytes. li resAes a Model to Study C 8 Utilization in Perfused Arteries from Different Regions. Kishi. Yukio_ Estrogen and Calcium u Hypolipidemic Drug ' Metabolism Jn Aortic Wall. _ - Metabolism and Effects. 39 Anyanwu. Enyeribe Electron Microscopic Obser- 30 Laymen, ppn r- Anti, Atherogenie Effects of Dimethyl Sulfoxide In Rebbits Fed CholesteroL 0 vation on the Synthesis of Lipids in the Human Aortic Media. Gendre. Philippe M. J. Smooth Muscle Cells e d h SMOOTH MUSCLE CELL - I n t e Initiation of Arterial Pathological Processes. Azalea Room Chairpersons Alan J. Day Katti Fisdter-Dzoga

THE ARTERIAL WALL - I •eroaa. 41 Bluebonnet Room Chairpersons t:oiin W. M. Adams Kazunart Wada First Author JFiNineh. Harry Title Morphological Features of Aftered Permeability in -- Atherosclerosis. 42 Asmuss+:n, Inger Coronary Risk Factors investigated in an Experimen- tal Modei- in Man. Ultra- structural Studies on the - Fetal Cardiovascu)ar System at Birth. 43 Johnson. W.T.M. Studies of Lfpid/Protein Ratia_Hydroxyproline and Proline in the Intima in / 44 Yoshidn. Yoji Relationship to Arterial Occlusive Disease. Cerebral Thrombcsis: Patho- genesis of Tear at Periphery of Plaques. Arterial Calcifications. Vasa Vasroum in Coronary Arteries and Their Rote in Progression of.Coronary SClerosis. 47 SchwlF-pett. Berbera Increased Rough Endo- 48 tVicvR, Anne ptesmatic Reticulum 1" Skin - Fibroplasts from Patients with 3 Dirterent Types ot Familial Hyperlipoproteinernia Lipoprotein Flux in Normal and Abnormal Human Artery Wall. 49 Tracy. Richard E. Aortic Atherosclerosis as a. Poisson Process. NON-DIETARY, NOR7-PHARMACQLOGIC/4.e. THERAPY OF HYPERLIPOPROTEIWEMI&1- I Normandy A Room Chairpersons Bruce A. Kottke Akiro Yamamoto First Author Title 51 Gevers Leuven. Jan A. Effect of Plasmapheresis or Insulin Sensitivity Plasma G/ucagon, Lipids and Apo- proreins "n a Type V Hyper- lipoproreinemic Man. 52 KWmeier, Martin Reproducibility ol the Lithogenic Index of Hum.-n 8ile. 53 Weizel, Achim influence_ofPorlocavalShunt- on Lipid Parameters in Cirrhosis. 54 Rossner. Stephan HOL After By-Pass Surgery in Severs Obesity. 55 Postigllone. A.liredo Serum Lipoprotein Concen- tration and Early Signs of Atherosclerosis of Lower Limbs in Thyroidectomized Patients. 56 Witztum, Joseph L. Successful Plasmapheresis in a Four Year Old Child with Horriozygous Familial Hyper- Cholesterolemia (HFH). 57 Rossouw, Jacques E. The Lipid-Lowering Effect of Portacaval Shunt. 58 Faergeman, Ole Aeal By-Pass Surgery for Familial Hypercho/esterolemiaa

)I ~ HORMONE EFFECTS ON 68 Wahlberg, Gustaf K. Increased High Density Lipo- HYPERLIPOPROTEINEMIA - I protein (HDL1 Cholesterol (CHOL) During IYicotin3c i Acid Treatment of Hyper- lipemic Patients. Venetian Room 69 Kushwaha Ramprata Efr S t f . p . ec o Exogenous Estro- Cttairpersons gens on Lipoproteins in aem.,ct, 61 Goran WaIIC+us First Author 9allanEyne, Fiona C. Kjell Helistrom Normal and Cholesterol-Fed Title Pigtail Monkeys (Macace Nemestrina). The Effect af Thyroxine Ther- ~ 70 Malkanen, Marjstte Lipoproteins. LCA T and apy on the Composition Of Low Density Lipoprotein Sub- Lipolytic Activity in Hypo- fractions in Primary I physectomised Rats. I idi n A L i sm. Hypothyro ~ RgGl8Li4TION OF CELLULAR ~ e 62 . eo S ntons. - pphore ctomize d Women. CHOLESTEROL METABOLISM - I Elena N i High Density Lipoprotein i 63 . mova. Geras Subtractions and Sex Hor- mones in Mates Plasma. { Nile Room 64 1-iirvonen, Erkki : me opause~Women During I Chairpersons Godfrey Getz 0. Roger lllingworth ~ Estradiol Vaterianate •e«.,n e First Author Title bined with Different 5 amai. Toshitaka Com Types of Progestins and in Endometriotic Subjects Dur- ing Progestin Treatment. Effects of Oxendrolone on 71 Koiiumi, Junji Regu/etion of Lipogenesis Isolated Hepatocytes by Intestinal Chylomicrons and i Their Remnants. 0 Plasma Lrpoprotems m Patients with Type ila, tib and IV Hyperlipoproteinentie. Occurrence of Hypo-High Density Lipoproteinemia. 72 Turner, Peter Splanchnic Metabolism of Plasma Apollpoproteins in Man. 73 Calandra, Sebastlano Catabo/fsm of LP-X in 1 66 David M. Spain - Paradoxical Effects of Estro- Isolated Rat Hepetocytes. ( , gens on Atheroma. I 74 Young, Nancy L Diabetes increases Rat intestinal HMG-CoA 67 Pagnan. Antovio Serum Lfpids and Apoprotein Composition Of the Very Low Reductase. ~ Density Lipaprotein (VLDL) Fraction in Hypothyroid 75 Maume. Gabrielle Cholesterol Synthesis and Metabolism Regulations by i I Patients Before and During Reptrrcement Therephy. Epithelial Liver CeN Culture. Establishment of an tn Vltro Cellular Model. 76 - 8ar-On, Hanoch Hepatic Lipoprotein Secretion in .Experimental Diabetes Mglli..- I i -9

98 iVialmendier. Claude L. Isolation and Partial Chbrac- 107 t7ousset, Jean Claude terization of NewApoproteins from Human High Density 108 Segrest Jere P 9 erova. Natalia '!. 1 ipoproteirrs. Effects of Dietary Changes. A Spin Label Study rif Plasma . . Upoproteins in Hyperalphalipoproteinemia. 109 Pownati, Henry J. 100 TverdiStoV, Vsevolod A. Studies of the Non-Receptor Interaction of Plasma Lipo- proteins with Model Lipid Membranes. 10 outar, Anne K. LCAT-I Arterial Cholesterol Esterifying Activities. Transler end -Exchange of - Cholesterol Between Lipo- proteins or HDL Recombi- nants and Human AOrtic Smeoth Muscle Cells. Activation of Lecithin: Cholesterol Acyltranslerese by a Synthetic Model of a Human Plasma Apo- lipoprotein. Lecithin: Cholesterol Acyl- transferese Activation and Lipid Binding by Synthetic Fragments of Apolipo- protein A-L CARDIOLOGY - MYOCARDIAL ISCHEMIA - I Absum• 101 Frst Author Hans Diepiinger Title A Fast and Simple Method for Castilian A/B/C Room . LCA'T Determination: A Modi- Chairpersons 102 Subbaiah. Pap>rsajli V. fied Enrlmatic Procedure. I Low Density Llpoproteln ~ .ex.eer. Mark Entman First Author Kenzo Tanaka Title ((.DL) Activated Lysolecithin 1f1-- Paulson, Dennis J. Changes In the Heart Acylatfon by Human Plasma Lecithin: Cholesterol i Triglyceride Fatty Acid (TGFA) Composi!ion with 103 Schmitz.-Gerd Acyltransterase (LCAT). LCAT in Tangier Disease. 112 Pratt. Craig-M. ExperimentatDiabetes. Ambulatory Electro- I 104 JahanE. ARehmcwsh pensi~ifrpoAro eltts (HDL)h cerdiographic P+edictors-o7- Ventricular Tachycardia in t 105 Batthotom® Margret Lecithin: Cholesterol Coronary Artery Disease. . Acyltranserase. An Improved 113 Reid, John W. Assessment of Postoperative pg On;. Giovanni Assay System and Substrate Specification of Different Plasma Lipoproteins, Comparative Effects of C/o- fibrete and Beialibrate ort Various Er•.zy.nes Involved in 14 inask.,Juri Left Ventricular PeNornnance - Followirrg Aortocoronary Bypass Surgery with - Sequentisl Gated Cardiac Blood Pool lmaging. PaYhophysiology of Coronary Cholesterot IBiosynthesis. Flow. Belvedere B Room Chairpersons Christopher J. Fielding John D. Bagdade

115 Michael. Lloyd 11 . The Cardiac LymplF in Early 115 Seidel. Charles L. Myocardral ischemia in Conscious Dogs. Phannacologic and Bio- 17 utphy, David L, chemicat Adaptations of Surgically Grafted Saphhenous Veins. Quantitative Studies of 118 McMillin-IRrood. Jeanie B. lschernic Canine Jbryocardiurrr. Lipid Metabolitas and Ca7• i 19 Ballantyne. David D. Transport Interaction In Cardiac Mitochondria. Effect of Myocerdiai Jnlerc- tion on Plasma Lipids and Lipoproteins. OiEMODYNAMICS - I Camellia Room Chairpersons ; Robert M. Nerem Sandor Gero aoBbVa. First Author Title 121 Cotnhifl. J. Fredvick 122 Spence. J. Oavic ~ 123 Tomitr.. Takako A. 924 tiirobumi. tlletoid -Localization of Atherosale- -- ros;s Lesions in the Human Basilar Artery. Effects of Antihypertensive Drugs on 81ood_ Velocity in Man. Hemodynamic Effect on Aortic Cholesteryl Ester Hydrolase Activity in the Rat. A Study on i3toorr vrscosnYrrr CVA - The Relationshlp Batwreen Blood Viscosity and Duration After Stroire and the Effect of Pentoxifyltln. I ; 3 E I 125 Wrobiewski. Tadeusz E. 126 Leszcynski, Dennis E. Effect of Excess Free Fatty Acid (FFA) on Contractile Response of Vascular Smooth Muscle. In Vitra Evaltration of Hemo- dynamics and Hyperlipidemia as Refative Risk Factors in Atherosclerosis. 127 Zarins, Christopher K. Effects of Coerctauon on Aortic Athbrosclerosis and Connective Tissue Content. 128 Silberhauer. Karl Development of$udanophilic Lesions Around Aortic Ostis of Human Fetuses. Newborn and Children. 129 Radvan-Ziemnowic:, Early Diagnosis and Progno- Sten A. - sis in Cerebral Atheroscfe- rosis by Non-Pnvasive Methorl of Regional Rheoelicephalo- gmphy (RRF. G). 401 Nash. David T. Timo/ol In Hypertension.

PR -- GRA - lNFOIVBAI'! N WED ES®AY ®ore ber 7th, 1979

® tAIIMUP'OLOGY Bluebort..e Room ' Chairpersons ~ C. Richard Atinick John O. Mathews 4. J. L Beaumont I Carl G. tlecker ~ Participants Recent Advances in Autoirnmune Hyperlipidemie Tobacco, Immunologic ttfjury and Cardiovascular Disease Francis V. Chisar9 Immunoreguiatory Lipoproreins, Viral ~ HepBtitus and Cancer ~, Thomas S. Edgington ~pht~~ ~if erentiat ontby the Serum Lipoprotein: LDL-in ~: Anatoli Klimov The Rote of Autotmmune Mechanisms- /4y in the Devetopment of Atheroscterosis •dis, John D. Mathews lnteraction of Genetic and fnviron- ~ mentat Factors Causing Atheroscle- / ` rosis by Immunologic Mechanisms f 1 C. Richard Milnick tmmunotogic Arterial tnlury and / Atherogenesis , ANIMAL MODELS - Grove Room T Draga Vesseiinovitch Reversa/ of Atherosclerosis: Evaiuation of Primate Models ENZYMES OF LP METABOLISM Camt31lia Room Chairpersons John A. Glomset Keare R. Norum Participants Virgil Brown Christopher J. Fielding Esko Nikkita Thomas Olivecrona How Does Lipoprotein Lipase Bindlo- Subs:rate Lipoproteins and How Is /ts Activity Regulated Lvuds-C• 8mith Activation of Lipoprorein Lipase by Synthetic Fragments of ApoC-11 ANIMAL MODELS OF ATHEROSCLEROSIS - !i Embassy Room Chairpersons . i ° q-6-7 PY ~ Chairpersons Thomas S: Clarkson Henry C. McGili Dieter a;. Kramsch Giorgio Weber David Kritchevsky Participants Nutritionai Factors In Atherosclerosis Aba•«ee 131 First Author Stender, Steen Title Tiansfer of Labeled Esterifled i Robert H. Mahley Satisanur R. Srintvssn Cholesterol lnduced Hyperpro• teinemia In Atherosclerosts in Dogs, Swiae and Monkeys Dletery Animal Models for Studying 32 ankin, Vadim 2. Cholesterol from Chylo- microns into the Arterial Wall of Rabbirs. Ent.vme Systems of Gener- / Wilbur A. Thomas CarrJiovascular Disease Risk Factors Transformation of Naturally Occurring Ouiescent fntimal Snwoth Muscle Cetl Masses into Atherosclarotic 33 tange. Eduard F. ation and Detoxicetion of Active Forms and Oxygen in Experirnerttal Athenoselcrosis. In Vivo and In Yttro Regule- I Lesions in Swine Fed Hyperlipidemic Diet tion of 3 •Hydroxy-3-iNethy, glutaryl-COA-Reducrase in Pbe n.._,--•---• - - - - - r.

134 Wurm. Heimut 135 Clopatfis. Peter Jnvesrigation of a Atew Apo- poprotein" in the Rat: Demonstration of a,-(3lyco- protein-t in all Major Lipo- protein Classes. MorphologJcal and Bio- chemical Studies During Atnerogenesis fn Swine. 136 Kohter. Constarce A. PlateJet Survival Time as an a e l 137 Sadava. David 138 Saito. Yasushi 139 Cho. Byung H. g . ar am index of Vascu Effect of Vitamin C on Rapid inductiori- of 1Atherasclerasis in Rabbits. Studies on Lipid Metabolism In Arterial Wall. Plasma Lipid Profiles. Hepatic Cholesterolgenesis and Aortic Lesions in Layer and Hereditary Nonlayer Chickens. 140 Chakravatti, R. N: Study of Spontaneous Atherosclerosfe in Wild Rhesus Monkeys. An EKpe- rience of 15 Years_ - • EPI®EMi®1.®Glf - i1 I illarco Polo Room ~ Chairoersons- ~ Nits H. Stenaby William Insuii. Jr. E ,e.MNA . First Author Titie ~ 141 tWaConathy. Mlsiter J. Cord Serum Lipids and Apolipoprofeins in PerinatJ - Disorders. ! 142 woidow. Asher a~fe~r~jsgi the Aged. 143 Coyer. Alan R. ~ 0e8th~m Cancer and Other Causes In Three Chicago BpJdemiological Studies.: 144 Heiss. Gerardo Detection of Type 11A Hyperlrpoprofeingma from Tolal Cholesterol Measure- menrs in a Pediatric Population: The Lipid Research Clinics Program (LRC). 145 Feigl, Walter Atherosclerosis in Mortality e Statish'cs. 146 Fordyce. Marianna K. Adipose Tissue Fatty Acid Compositiocr of Cretan Men With and Without Myocardial Inlarction (MI). vnd Their Children_ 147 Hailer, Hans Risk Factors in Oral Treated Diabetics. 148 Staheiin, Hannes 3. HDL-Cholesterol, Risk ~ Factors and LilaF Style in Families of a Working Population. 140 Shutman, Richard S. Peri-Inrercfion Changes in Cholesterol, HDL-Cholestero/ and Apolipoprotein A-l. 150 Ataupovic, Polar Plesmte-Apofepoproteilr Levels in Patients with Abetalipoproteinemia and Hypobetalipoproteinemie. DRUG EFFECTS AND THERAPY tff MAN-=-1I- nasrcea s Grove Ro Chair ons Ole Faerge n Fumlo Kutuys First Author Title 151 Wechster.~Jotf nes E3. DL-andLDL•Cholesterolin Pa fs with HyperlipidenNa Type IlA Trested With Different Lipid Lowering Drugs.