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I11teati®nai , Symposium ® Atherosclr®sis + 1 ; ` November 6-9,1979 Houston, Texas 1" 1 i , i ~ Program under the auspices of the Internationat Atheroscterosis Society Honorary Sponsors Mrs. Mary Lasker Princesse Lilian Co-Sponsoring Institutions 9aytor College of Medirine The Methodist Hospital

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t3e9c Frker~ Message from the Chairman, V Infernational Symposium on Atherosclerosis TtysOrganittingCCmmittee otttte V 1nlemetic+mfSymposarmanak~erosde.osis Thg Meihodist NOSprtat end 6sytorCoqege o! Medicine }oin me {n welcoming you to "0uston. TRis6yntPos+uin is suppmled by meny indivkdut:tsend orger+izattons. The Mgthodist Hospital erd t3aybx College of Medicine have made it Poggibte to hold 'Ghe Meeiing +n Houston. Or William Holmes directed the fund raising aotivitie6 nutside of Texas. The CAUntal On Athero9oterosis ot trte American Heart Aasoc+ation. the Texas ANitttte and the Houston Chapter o1 the American HeeR AS3oCi8twn ttre Co-Spord0*V this meaLng. We are espaciany honored to hev0 as out HottorElry Co-SPO1t80ts Ct the $ymposyunt. Mrs. Mery Lasknr Irom h1ewY0rlt and Print:eSSOLiliBn ot 9elgium.whp ere t-o o1 the wortde +nomd-stinguished 8upportere ol8iomsdtcel Research. They Rave troth bsen especially intereste0 in progrmns tortne treaanent and prevention of t8rdtovlascuter drseese. tl is nsost eqropr:atethat Qe0 ol7ening SesSku n otihe Fhnntonsymposium steoutd be devoted to tqdoring Qottor Michael E. Det3sksy's eontritrutwna to the surgical il08tneent of gtherOgGlgrwis. The Symposium t><mg8 together a rerr9ty ot Owiplmes. tvom cardWvascutar surgsons to se+entists intereste0 in dret. platelets. Pr0518gtttndms. the rffoleaul9r UuitM of the arterial wetl, and the pethoganesisot 81herOgClerdgig in Iipid and 4poprotein met8U01i9T. A special coilOq W Wti to be held on wedneYdAy Brening. Nnvemtfer 7th under the 9uBPwAs of the PrinCegSe Lilian Cerdsoyogy Foundatron. will focus onthe quest+on ot the OeWining Deatfi Rate from CoronBry Artery Oi,sease Nre atticipetetnat the presentation and drstussion of new disCOV61t890rM new ecAsesemente witl excite imestigetonto erenewed dedicatwn towarda the eorsquesi ot eerd,ovaseular disease. ThBSoGiatprogr8rn tstgm2s the OosmopW iten toveh of the weMd'e fexemose oil eity wHh some Te>r&s atyleg8r• 3-OrJe end Rodeoaatiritres.On behaf?ot tny staff and the prgenriing Cormnittee. wo nope that you spend an Interesting and enjoya0le week In Houston. Yours sirucerety. ~~ K. 4;EG:- 1)

, INTERNATIONAL PROGRAM COMtwITTEE: Jean-Louis Beaumont Henry Buchwald - Lars A. Carlson William E. Connor Alan J. Day Fredric H. Epstein Yuichiro Goto Antonio M. Gotto, Jr. M. Daria Haust William L. Holmes Anatoli N. Ktimov David Kritchevsky K. T. Lee Kare R. Norum Michael F. Oliver Rodolfo Paoletti Gotthard Schettler Gunther Sclllierf Yechezkiel Stein Daniel Steinberg Jack P. Strong AD HOC ADVISORY COMMITTEE: Gustav V. R. Born H. Bryan Brewer, Jr. Richard J. Havel Robert I. Levy Robert W. Mahley Russell Ross - Richard W. St. Clair David C. Sabision, Jr. Angelo M. Scanu Colin J. Schwartz Harvey Wolinsky 4 FUND RAISING COMMITTEE: CHAIRMAH~- William L. Holmes Lars A. Cartson Yuichiro Goto W. Dsria Haust David Kritchevsky Henry C. McGill Paul J. Nestel- Michael F. Oliver Rodolfo Paoletti Gotthard Schettler Yechezkie( Stein Daniel Steinberg - Robert W. Wissler TEXAS ORGANIZING CO@YINtITTEE: CHAIRMAN: Louis C. Smith Arthur C. t3eall Gerald S. Berenson Mark L. Entman Joseph L. Goldstein Dudley Hafner Sam Inman Henry C. McGill Richard R. Miller Jerry R. Mitchei( Joel D. Morrisett Josef R. Patsch Henry L. Pownall James T. Sparrow Jack t_. Titus LOCAL RECEPTION COi'd1MITTEE: Mrs. Ted Bowen Mrs. AntonioiVl. Gotto, Jr. Mrs. Randolph Schaffer

11 .. aNSMUT oNs AND CORPOAATIONs: Baylor College of Medicine The Methodist Hospital The International AtIerosclerosis Society Council on Arteriosclerosis of the American Heart Association The American Heart Association The American Heart Association; Texas Affiliate The American-Heart Association; Houston- Chapter Abbott Laboratories Ayerst Best Foods Burroughs Wellcome Company Ciba Geigy Corporation Dow Chemical L.ompany. USA Hoffman-La Roche. Inc. hmecican Cyanamid Company Eli Lilly and Company McNeil Laboratories- Mead Johnson Pharmaceutical Division Merck Sharp & Dohme Research Laboratories Norwich Eaton Miles Laboratories, Inc. Ortho Pheirmaceutical Corporation - The Proctor and Gamble Company William H. Rorer, Inc. Sandoz, Inc. - Schering -Corporation G. O. Searle and Company Smith, :Clirte-and-Erench Laboratories Standard Brands, Inc. Sun Company Syntex Research The Upjohn Company Wyeth Laboratories,-Inc. ACKNO1AfLEDGEMEN'PS• We gratefully acknowledge these individuals, institu- tions, organi2ations and companies whose generosity and support have made this meeting possible: THE ORGANIZING COMMI[TTEE. CHAIRMAN Antonlo M. Gotto, Jr. CO-CHAIRMAN Yuichiro Goto GENERAL SECRETARY Louis C. Smith

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11 SCIENTIFIC hROGRAM AT A GLANCE Belvedere B Room LC LENARY SESSION: Grand 9atirosm - Tuesday :30 a.nfl. - 12:00 noon Cardiovascutar Surgery AT - I Castiiian,A/B/C Room Cardiology - Myocardial tschemia -1 Cameliia Room Hemodynamics - i USNngs !ol iyorASNpP Proglanrs do nof neeesaarfy l6//gC/ Olde/ ol P'"emdrfbng. WORKSHOPS: 1:30 - 4:00 p.m. SCIENTIFIC PROGRAM AT A GLANCE Embassy Room Coronary Bypass Surgery Wednesday ,t;',rQve Room Epidemiology of Atherosclerotic Lesio ". PLENARY SESSION: 8:30 a nt 0 i Grand Bailroom . . 0 noon Marco Polo Room Drug Treatment of Hyperlipidemia Dietary Prevention of Coronar H Azalea Room The Arterial Wall -1 y eart Disease Bluebonnet Room Lipid. Apoprotein and Lipoprotein Origin and Synthesis - WORKSHOPS: 1:30 - 4:00 p m Camellia Room Lipoprotein Structure Azalea Room . . Hype+lipidemia: Pnsvatence and Inh eritance Embassy Room Risk Factors In Children ORAL PRESSPe'YIC4tOP3S: 4:00 - i6:30 p.m. Marco Polo Room Diet Treatment of Ath Embassy Room Animal Models of Atherosclerosis - I Bluebonnet Room Grove-Room - eroscferosis immunofogy A Marco Polo Room Epidemiology - I _ Cameiiia R nimal Models Grove Room Drug Effects in Animals - I oom EnzY+nes of LP Metabolism Azaie,e Room Smooth Muscle Cell - I BtueBionnet Room The Arterial Wail - I ORAL Q:00 . Normandy A Room Non-Dietary. Non-Pharmacological PRESENTATIONS: • 6.3b p.m. Therapy of Hyperlipoproteinemia - I Azatea Room Smooth Muscle Cell - it i/enatian Room Hormone Effects of Hyper- li Bluebonnet Room The Arterial YVap poproteinent€a - I Venetian Room - il Diet-11 Nile Room Regulation of Cellular Cholesterol N ormandy A Roo Metabolism - ! m Metabolic Origin •of Hyper- Belvedere A Room LDL Structure - t N ile Room lipidemia -11 Normandy i} Room HCIt_ Strucfiffa . I s -•- - - LOL Metabolism - il

v Normaady S Room Belvedere B Room Casuiiian A/S/C Room Embawj Room Marco Polo Room Grove Room Lipoprotein Lipase - 11 Thrombosis and Immune Complexes - I Risk Factor Modification Animal Models of Atheroscterosis -11 Epidemiology - tl Drug Effects anii Therapy In Man - II Lis&W ror W.arknnop Frogrmns do nor neoessaNty relfecl ord6r ol praagnrBfiOn SCIENTIFIC PROGRAM AT A GLANCE 'Thursday QLENARY SESSION: 8:30 a.m. - 92:00 noon Grand Ballroom The Vessel Wall in Atherosclerosis WORKSHOPS: Marco Polo Room Azalea Room Embassy Room Grove Room Btuebonnet Room Camellia Room 1:30 - 4:00 p.m. Non-Dietary. Non Pharmalogical Treatment of Hypertipidemia HDL: Negative Risk Factor for CHD Ci6ical Trials The Arterial Wall - 11 Vessel Wail-Piatelet Interaction- Catabolism of Lipids, Apolipo- proteins and Lipoproteins ORAL PPIESENYATIOMS: Embassy Room Marco Polo Room Grove Room Azalea Room 4:00 - 6:30 p.m. Animal Models of Atherosclerosis - III Epidemiotogy - III Drug Effects and Therapy In Man - III Smooth Muscle Cell - I II t3tuebonnet Room Venetian Room Normandy Room Nile Room Belvedere Room Normandy g Room, Belvedere B Room - CastiNian A/B/C Room Cametlia Room rhe Arterial Wall - iu Oief - III . "Genetics of Hyperlipopro- teinemia - I I I LOL Structure - III HDL Itdetaboiism - /lt VLDL Metabolism Platelets Regression HDL - Negative Risk Facto r - 111 Lrsrnrtgs rar WorksAop FrograM d,,,w,, ~ssray r~lieer orofer or pigsenlerfon. SCIENTfFIC"19ROGRAAR AT A GLANCE Friday PLENARY SESSION: 8:90 a.tn, - Tg,0p noon Grand Ballroom Plasma Lipids, i-i~protetns Atheroscierosfs and WORKSHOPS: 61uebonnet Room Marco Polo Room Embassy Room Grove Room Azalea Room Cameiiia Room 1:3d1- 4:00 p.tro. Mutants Affecting .Lippprotein and Apoproteins HYpertension Regression The inter-Refationship Between t.ipid and Prostagiandin Metabolism Cellular Metabolism ot Lipoproteins Apoprotein Quantification

v- ORAL pRESEPlTATf ONS: Embassy Room Marco Poto Room Grove Room Azalea Room Btuetsormet Room Card Room Normandy A Room Nile Room Belvedere A Room Normandy B Room Beivedere B Room Castilian Room Qartselka Room 4:00 - 6:30 p.m. Animal Models of Atheroscierosis-IV Risk Factors in Children - IV Drug Effects and Therapy in Man - iV Endothefial Cell - IV The Arterial Wall - IY Exercise and Diet - IV Lipoprotein Methodology - tV LDL Metabolism - IV Apoprotein Structure - IV _ Lipoprotein Lipase - IV Prostaglandins - IV Risk Factor.Synergism HDL: Negative Risk Factor - IV Lrs/irrg5 for Workshop ProgrBms do not neaeseerily rotlsa' order of presentatfon. . Irm"OGRAM INIi-" MJ°i1TIO® UES®AY November 6th, 1979 k

PLENARY SESSION: CARDIOVASCULAR SURGERY 8:30 a.en. - 12:00 p.rst. - Grand Ballroom Chairpersons E. Stanley Crawford - David C. Sabiston. Jr. Participants Michael E. DeBakey Patterns of Atheroselerosis Harris S. Shumaker. Jr. Mechanism of Progress. Page from the History of Cardiovascular Surgery Charles Oubost Surgery of the Heart and Great Vessels David C. Sabiston. Jr. Surgery for Coronary Artery Disease CONCUR RENT WORKSHOPS: 1:30 - 4:00 p.m. CORONARY BYPASS SURGERY Embassy Room EPIDEMIOLOGY OF ATHEROSCLEROTIC 71 LESIONS- ~ Grove Room Chairpersons Yuichiro Goto Jack P. Strong tntroduction: Workshop on Epidemiofogy ot~ Atheroscierotic LesFons Participants- MaNo t3arcia-Palmeri ~~ l1w William B. Kannel Postmortem vs. Clinical Risk Factor Correlations. The Framingham Study. Lars A. Solberg Risk Factors for Coronary and Cerebrovascular-Atheroscferosis in the Oslo Study. Grant Stemmerman Atherosclerosis and Its Risk Factors Among the Japanese. Nils Sternby Atherosclerosis. Smoking end Other Risk €actors.- DRIDG TREATMENT OF HYPERLIPIDEMIA Marco Polo Room Chairpersons Michaei i=. DeBakey J. Willis Hurst Chairpersons David Kritchevsky Rodolfo Paoletti Participants Participants - John F. Goodwin My Current Vfeias Regarding ' Donald B. Hunninghake Drug Treatment of Type li Hyperlipo- Coronary Bypass Surgery proteinemia. Effects on Plasma Lipid and Lipoprotein Levels- Gerald M. Lawrie- Results of-Cof.onary Bypass: A-L-ong= John P. Kane Synergism fn Drug Treatment of Term Perspective Amilial Hyperct,ofesterolemia Henry D. Mcintosh Current Views Regarding Coronary Anatoll-N.- Klimov- Effect of Plasma Lipoextraction and Bypass Surgery - fnfustr'oa of Heteroiogous slDi orrthr Richard Pk. Milidr Comparison of Medical and Surgical Development of Experimental Mortatify in a Hfgh Risk Subject of ; Atherosclefosis In Rabbits Coronary Patients with Extreme David Kritchevsky Nutritional Factors in AtheroscJerosis Degrees of Exercise - ia l h Anders G Ol N em sc Induced . sson ew Drug Treatment in Hyperlipidemia David C. Sabiston. Jr. Cesare R. Sirtorl Apoprotein Changes Following Harris B. Shumaker, Jr. I TrAaln.o»rQ ...l0s. -- -

i THE ARTERIAL WALL -1 Azalea Room LIPOPROTEIN STRUCTURE Camellia Room Chairpersons Ch,airpersonc M. Oaria Haust Kenneth M. Walton H. Bryan Brewer Wifhelm Stoffel M. Daria Haust Coiirt J. Schwartz Abet Robertson ack t.. Titus Elspeth B. Smith Participants tntroducfion Uitrastructure on Normal Arterial t:ndofhelium Arterial EndOthelium In lnitial Stages of Atherogenesis Smooth Muscle Cells in i Atherosclerosis 0iochemical Studies on Permeability and /nteraction Between 81ood Constituents and Arterial Components in Atherosclerosis Discussants Participants German Camejo The Associating System of Smell Subunits in Apo LOL Richard L. Jackson Lipoprolein Structure-and;he Mechanism of Action -0t _ Lipoprotein Lipase Gerhard M. Kostner StructureofHighDensityL-ipoprofeins Joel D. Morrisett Structu ! S ra hedies o/ Cholesterylester- Rich Very L ow Density Lipoproteins (CER-VLDL) G. Graham Shipley Wiihef ~ m Stoftet Topochemical Studies on Human Serum High Density Lfpoprotein r~} ~! £y~~ ~C- F Colin W. M. Adams Scren Bojorerud CONCURRENT ORAL PRESENTA Lesie Robert TIONS 4:00 - 6:30 p.m. Kenneth M. Walton Summing-Up ANIMAL MODELS OF A THER . OSCLEROSiS - I LIPID, APOPROTEIN AND LIPOPROTEIN , ORIGIN AND SYNTHESIS Bluebonnet Room Chairpersons Richard J. Havel Barry Lewis i Shtomo Eisenberg Participants The Origin in Plasma of Low Density and High Density Lipoproteins Godfrey S. Gett 8iosynthesis of Rat Lipoprotein E Roltert M. Glickman Apoproteirf Searetion from Human lntestine Robert L Hamilton David B. Weinstein Embassy Room Chairpersons Douglas A. Eggen Jan Author Rapacz_ Title 2 Mu"Iler, Klaus R. Geneticatl H . lemic Rafs as Animals tor Hypolipidemic Drugs. 3 Kramsch. Dieter M. The Role ot Calcium in 4 Aschenbrener. Carol r. I terolemic Diet on Two-Kidney ~ (3o1db/atf Rabbifs. Atherogenesis-srrd-ita Suppression by Calcium lnhibitors in Primatbs. Effects or a Hypercho:es_ 1

r", 5 Keifey Jim L --•~ I The Turkey as a Modal for i , . Atherosclerosis: Quantifica- 1 tion of Plasma and Arterial ~ 6 eRey. Jim L. f Apolipoproteins by Eiectroimmunoassay. - Effect of Dietary Cholesterol [ on Plasma and Arterial Lipo- proteins in rhe Turkey. s 7 McTaggart. Fergus investigation of the Common [ Marmoset as an Animal 8 emura. Eliichi r Model for Lipoprotein Research. Experimental Atherosclerosis ~ 9 Mills. Gervase L Produced by Simple Sugar I Feeding. Induction of Hyperlipaeinia in - 10 Mills. Gervase t.. Gc inea Pigs. Serum Lipoproteins ol i Sturgeon. ~ EP1®EbV®LOGY I - ~ ~ Marco Poto Room Chairpersons Nemat Borhani David Brunner AbWWp 11 First Author Kupke, Ingeborg. R. Title Metabolic Factors Associated 2 Wallentin. Lars C. with Atherosclerosis. - Exami- nation of Young Children In Duesseldorf. Lipoprotein Lipids in ~. 13 applt. Jan J. Coronary Atheromatosis rnterrelationship Between 4 rank, Gall C. Ultracentrifugal and Electro- phoretic Patterns of Plasma Lipoproteins and Topogra- phy of the Pre-Al Cornpiex. The Relationship of Jntant Feeding Patterns to Coronary Risk Factor Variables in the First Year of Life. 15 Schneider, JOrgen Ather I os 16 tCutsumi, Yasunori '17 L~larriq, Jean 18 ®erchtoid, Peter 19 Hatano. Shuichi c erobc Comprica. J tions in Octo- and Non. agenarians Related to Hiyh- Density_Lipoprotein -Cho/esterol. Ethnica/ Dillerence o/ Plasma Llpoprotein Concentratfon in Adult and Umbilical Cord Blood.• Higher Levo10l plesnraHigh Density Lipoprotein (HDL) in Japanese. An Epideiniologicat Research . ol Ath erosclei ross Among Patients Presenting Vascular Risk Factor Without Any Clinical Vascular Symptom. High Densit y L fpopro tein- Cholesterol and Coronary Risk F ectors in Ob ese Patienrs. Trends o1lschenric H eart D sease Mtl 'oraity and Possible Risk Factors in Japan. 20 Angelico, Francesco The Rome Pro Coronary HABrr Disease Prevention: Evaiuation f o Ly,etary ChangesAltera Four- Ypar Intervention. ®RUG ErFECTS Ip ANIMALS -1 Grove Room Chairpersons Howard Eder Alan N. Howard First Author 21 _ Cayen, Mitchell N. r F V Title ~ Bspecrs oJ Serum Protein ` i ndmg of Clclibric Acid in Normal mw n..,-___. - -

1 22 thn Harry Y. C. Wong e r pn f l Abwftaip First Author Title . iDL Valrum O Etlecf ol 31 Uoneda. Genju Smooth Muscle Cells in the 3 Cholesterol Jri Atherogenic- Fed Roosters. Wu. Chun-Churg Mechanisms of Cholesterol Development of Atheroscle- rosis and Arterionecrosis of the Intracerebra/ Arteries. Lowering Effect uf Acupunc- 32 Reiniia. Aiti Accumulation of Lipid in 4 ture in Rabbits: A Plasma Factor. _ Langner. Ronaid O. Relationship of Tissue Muscular Arteries of Short- Term Diabetic Rats: Electron Microscope Study. Protein Synthesis to 33 Makita. Takashi Fine Structure of Elastic r Cholesterol Accumulation in Different Tissues of the Rabbit. Layers and Other Features ofg lntima/ Smooth Muscle Cell - Masses in the Abdominal 25 Jett. Charlene M. Shift in Guinea Pig Lipo- Aorta of Swine. protein Profiles Induced by 34 Newton, Sheila A. Characteristics of the 5= 6 aikonen. Marjatta Modulation of HMG CoA Reduc.tase Activity. Paradozical Altera.rC ns d b t Nucleotidase Activity of Swine Arterial Smooth Muscle. e Lipoprote+n Ltp+ds aus y 35 Morisaki. Nobuhiro Lipid Metaboliam in Aorta and Gemfibrozil. Clofibrate and Nicotinic Acid. 6 Brain Microvessels. Largis, Elwood E. E/lects of Cetaben Sodium 27 Fears. Robin B. The Effect of Compactin on Chotesterogenesis and Serum Cholesterot in Ftats and Chicks. 7 on Lipid Metabolism in Aortic Smooth Muscle Cells in Tissue Culture. Crass. Maurice F. Effects of Insulin and 28 Cheng. Davy C. H. Norethindrone Acetate Norepinephrine on Glucose 9 hessebeuf. Nadme L Inhibition of Hepatic Triglyc- erids Synthesis in Isolated Rat tiepatocytes. li resAes a Model to Study C 8 Utilization in Perfused Arteries from Different Regions. Kishi. Yukio_ Estrogen and Calcium u Hypolipidemic Drug ' Metabolism Jn Aortic Wall. _ - Metabolism and Effects. 39 Anyanwu. Enyeribe Electron Microscopic Obser- 30 Laymen, ppn r- Anti, Atherogenie Effects of Dimethyl Sulfoxide In Rebbits Fed CholesteroL 0 vation on the Synthesis of Lipids in the Human Aortic Media. Gendre. Philippe M. J. Smooth Muscle Cells e d h SMOOTH MUSCLE CELL - I n t e Initiation of Arterial Pathological Processes. Azalea Room Chairpersons Alan J. Day Katti Fisdter-Dzoga

THE ARTERIAL WALL - I •eroaa. 41 Bluebonnet Room Chairpersons t:oiin W. M. Adams Kazunart Wada First Author JFiNineh. Harry Title Morphological Features of Aftered Permeability in -- Atherosclerosis. 42 Asmuss+:n, Inger Coronary Risk Factors investigated in an Experimen- tal Modei- in Man. Ultra- structural Studies on the - Fetal Cardiovascu)ar System at Birth. 43 Johnson. W.T.M. Studies of Lfpid/Protein Ratia_Hydroxyproline and Proline in the Intima in / 44 Yoshidn. Yoji Relationship to Arterial Occlusive Disease. Cerebral Thrombcsis: Patho- genesis of Tear at Periphery of Plaques. Arterial Calcifications. Vasa Vasroum in Coronary Arteries and Their Rote in Progression of.Coronary SClerosis. 47 SchwlF-pett. Berbera Increased Rough Endo- 48 tVicvR, Anne ptesmatic Reticulum 1" Skin - Fibroplasts from Patients with 3 Dirterent Types ot Familial Hyperlipoproteinernia Lipoprotein Flux in Normal and Abnormal Human Artery Wall. 49 Tracy. Richard E. Aortic Atherosclerosis as a. Poisson Process. NON-DIETARY, NOR7-PHARMACQLOGIC/4.e. THERAPY OF HYPERLIPOPROTEIWEMI&1- I Normandy A Room Chairpersons Bruce A. Kottke Akiro Yamamoto First Author Title 51 Gevers Leuven. Jan A. Effect of Plasmapheresis or Insulin Sensitivity Plasma G/ucagon, Lipids and Apo- proreins "n a Type V Hyper- lipoproreinemic Man. 52 KWmeier, Martin Reproducibility ol the Lithogenic Index of Hum.-n 8ile. 53 Weizel, Achim influence_ofPorlocavalShunt- on Lipid Parameters in Cirrhosis. 54 Rossner. Stephan HOL After By-Pass Surgery in Severs Obesity. 55 Postigllone. A.liredo Serum Lipoprotein Concen- tration and Early Signs of Atherosclerosis of Lower Limbs in Thyroidectomized Patients. 56 Witztum, Joseph L. Successful Plasmapheresis in a Four Year Old Child with Horriozygous Familial Hyper- Cholesterolemia (HFH). 57 Rossouw, Jacques E. The Lipid-Lowering Effect of Portacaval Shunt. 58 Faergeman, Ole Aeal By-Pass Surgery for Familial Hypercho/esterolemiaa

)I ~ HORMONE EFFECTS ON 68 Wahlberg, Gustaf K. Increased High Density Lipo- HYPERLIPOPROTEINEMIA - I protein (HDL1 Cholesterol (CHOL) During IYicotin3c i Acid Treatment of Hyper- lipemic Patients. Venetian Room 69 Kushwaha Ramprata Efr S t f . p . ec o Exogenous Estro- Cttairpersons gens on Lipoproteins in aem.,ct, 61 Goran WaIIC+us First Author 9allanEyne, Fiona C. Kjell Helistrom Normal and Cholesterol-Fed Title Pigtail Monkeys (Macace Nemestrina). The Effect af Thyroxine Ther- ~ 70 Malkanen, Marjstte Lipoproteins. LCA T and apy on the Composition Of Low Density Lipoprotein Sub- Lipolytic Activity in Hypo- fractions in Primary I physectomised Rats. I idi n A L i sm. Hypothyro ~ RgGl8Li4TION OF CELLULAR ~ e 62 . eo S ntons. - pphore ctomize d Women. CHOLESTEROL METABOLISM - I Elena N i High Density Lipoprotein i 63 . mova. Geras Subtractions and Sex Hor- mones in Mates Plasma. { Nile Room 64 1-iirvonen, Erkki : me opause~Women During I Chairpersons Godfrey Getz 0. Roger lllingworth ~ Estradiol Vaterianate •e«.,n e First Author Title bined with Different 5 amai. Toshitaka Com Types of Progestins and in Endometriotic Subjects Dur- ing Progestin Treatment. Effects of Oxendrolone on 71 Koiiumi, Junji Regu/etion of Lipogenesis Isolated Hepatocytes by Intestinal Chylomicrons and i Their Remnants. 0 Plasma Lrpoprotems m Patients with Type ila, tib and IV Hyperlipoproteinentie. Occurrence of Hypo-High Density Lipoproteinemia. 72 Turner, Peter Splanchnic Metabolism of Plasma Apollpoproteins in Man. 73 Calandra, Sebastlano Catabo/fsm of LP-X in 1 66 David M. Spain - Paradoxical Effects of Estro- Isolated Rat Hepetocytes. ( , gens on Atheroma. I 74 Young, Nancy L Diabetes increases Rat intestinal HMG-CoA 67 Pagnan. Antovio Serum Lfpids and Apoprotein Composition Of the Very Low Reductase. ~ Density Lipaprotein (VLDL) Fraction in Hypothyroid 75 Maume. Gabrielle Cholesterol Synthesis and Metabolism Regulations by i I Patients Before and During Reptrrcement Therephy. Epithelial Liver CeN Culture. Establishment of an tn Vltro Cellular Model. 76 - 8ar-On, Hanoch Hepatic Lipoprotein Secretion in .Experimental Diabetes Mglli..- I i -9

98 iVialmendier. Claude L. Isolation and Partial Chbrac- 107 t7ousset, Jean Claude terization of NewApoproteins from Human High Density 108 Segrest Jere P 9 erova. Natalia '!. 1 ipoproteirrs. Effects of Dietary Changes. A Spin Label Study rif Plasma . . Upoproteins in Hyperalphalipoproteinemia. 109 Pownati, Henry J. 100 TverdiStoV, Vsevolod A. Studies of the Non-Receptor Interaction of Plasma Lipo- proteins with Model Lipid Membranes. 10 outar, Anne K. LCAT-I Arterial Cholesterol Esterifying Activities. Transler end -Exchange of - Cholesterol Between Lipo- proteins or HDL Recombi- nants and Human AOrtic Smeoth Muscle Cells. Activation of Lecithin: Cholesterol Acyltranslerese by a Synthetic Model of a Human Plasma Apo- lipoprotein. Lecithin: Cholesterol Acyl- transferese Activation and Lipid Binding by Synthetic Fragments of Apolipo- protein A-L CARDIOLOGY - MYOCARDIAL ISCHEMIA - I Absum• 101 Frst Author Hans Diepiinger Title A Fast and Simple Method for Castilian A/B/C Room . LCA'T Determination: A Modi- Chairpersons 102 Subbaiah. Pap>rsajli V. fied Enrlmatic Procedure. I Low Density Llpoproteln ~ .ex.eer. Mark Entman First Author Kenzo Tanaka Title ((.DL) Activated Lysolecithin 1f1-- Paulson, Dennis J. Changes In the Heart Acylatfon by Human Plasma Lecithin: Cholesterol i Triglyceride Fatty Acid (TGFA) Composi!ion with 103 Schmitz.-Gerd Acyltransterase (LCAT). LCAT in Tangier Disease. 112 Pratt. Craig-M. ExperimentatDiabetes. Ambulatory Electro- I 104 JahanE. ARehmcwsh pensi~ifrpoAro eltts (HDL)h cerdiographic P+edictors-o7- Ventricular Tachycardia in t 105 Batthotom® Margret Lecithin: Cholesterol Coronary Artery Disease. . Acyltranserase. An Improved 113 Reid, John W. Assessment of Postoperative pg On;. Giovanni Assay System and Substrate Specification of Different Plasma Lipoproteins, Comparative Effects of C/o- fibrete and Beialibrate ort Various Er•.zy.nes Involved in 14 inask.,Juri Left Ventricular PeNornnance - Followirrg Aortocoronary Bypass Surgery with - Sequentisl Gated Cardiac Blood Pool lmaging. PaYhophysiology of Coronary Cholesterot IBiosynthesis. Flow. Belvedere B Room Chairpersons Christopher J. Fielding John D. Bagdade

115 Michael. Lloyd 11 . The Cardiac LymplF in Early 115 Seidel. Charles L. Myocardral ischemia in Conscious Dogs. Phannacologic and Bio- 17 utphy, David L, chemicat Adaptations of Surgically Grafted Saphhenous Veins. Quantitative Studies of 118 McMillin-IRrood. Jeanie B. lschernic Canine Jbryocardiurrr. Lipid Metabolitas and Ca7• i 19 Ballantyne. David D. Transport Interaction In Cardiac Mitochondria. Effect of Myocerdiai Jnlerc- tion on Plasma Lipids and Lipoproteins. OiEMODYNAMICS - I Camellia Room Chairpersons ; Robert M. Nerem Sandor Gero aoBbVa. First Author Title 121 Cotnhifl. J. Fredvick 122 Spence. J. Oavic ~ 123 Tomitr.. Takako A. 924 tiirobumi. tlletoid -Localization of Atherosale- -- ros;s Lesions in the Human Basilar Artery. Effects of Antihypertensive Drugs on 81ood_ Velocity in Man. Hemodynamic Effect on Aortic Cholesteryl Ester Hydrolase Activity in the Rat. A Study on i3toorr vrscosnYrrr CVA - The Relationshlp Batwreen Blood Viscosity and Duration After Stroire and the Effect of Pentoxifyltln. I ; 3 E I 125 Wrobiewski. Tadeusz E. 126 Leszcynski, Dennis E. Effect of Excess Free Fatty Acid (FFA) on Contractile Response of Vascular Smooth Muscle. In Vitra Evaltration of Hemo- dynamics and Hyperlipidemia as Refative Risk Factors in Atherosclerosis. 127 Zarins, Christopher K. Effects of Coerctauon on Aortic Athbrosclerosis and Connective Tissue Content. 128 Silberhauer. Karl Development of$udanophilic Lesions Around Aortic Ostis of Human Fetuses. Newborn and Children. 129 Radvan-Ziemnowic:, Early Diagnosis and Progno- Sten A. - sis in Cerebral Atheroscfe- rosis by Non-Pnvasive Methorl of Regional Rheoelicephalo- gmphy (RRF. G). 401 Nash. David T. Timo/ol In Hypertension.

PR -- GRA - lNFOIVBAI'! N WED ES®AY ®ore ber 7th, 1979

® tAIIMUP'OLOGY Bluebort..e Room ' Chairpersons ~ C. Richard Atinick John O. Mathews 4. J. L Beaumont I Carl G. tlecker ~ Participants Recent Advances in Autoirnmune Hyperlipidemie Tobacco, Immunologic ttfjury and Cardiovascular Disease Francis V. Chisar9 Immunoreguiatory Lipoproreins, Viral ~ HepBtitus and Cancer ~, Thomas S. Edgington ~pht~~ ~if erentiat ontby the Serum Lipoprotein: LDL-in ~: Anatoli Klimov The Rote of Autotmmune Mechanisms- /4y in the Devetopment of Atheroscterosis •dis, John D. Mathews lnteraction of Genetic and fnviron- ~ mentat Factors Causing Atheroscle- / ` rosis by Immunologic Mechanisms f 1 C. Richard Milnick tmmunotogic Arterial tnlury and / Atherogenesis , ANIMAL MODELS - Grove Room T Draga Vesseiinovitch Reversa/ of Atherosclerosis: Evaiuation of Primate Models ENZYMES OF LP METABOLISM Camt31lia Room Chairpersons John A. Glomset Keare R. Norum Participants Virgil Brown Christopher J. Fielding Esko Nikkita Thomas Olivecrona How Does Lipoprotein Lipase Bindlo- Subs:rate Lipoproteins and How Is /ts Activity Regulated Lvuds-C• 8mith Activation of Lipoprorein Lipase by Synthetic Fragments of ApoC-11 ANIMAL MODELS OF ATHEROSCLEROSIS - !i Embassy Room Chairpersons . i ° q-6-7 PY ~ Chairpersons Thomas S: Clarkson Henry C. McGili Dieter a;. Kramsch Giorgio Weber David Kritchevsky Participants Nutritionai Factors In Atherosclerosis Aba•«ee 131 First Author Stender, Steen Title Tiansfer of Labeled Esterifled i Robert H. Mahley Satisanur R. Srintvssn Cholesterol lnduced Hyperpro• teinemia In Atherosclerosts in Dogs, Swiae and Monkeys Dletery Animal Models for Studying 32 ankin, Vadim 2. Cholesterol from Chylo- microns into the Arterial Wall of Rabbirs. Ent.vme Systems of Gener- / Wilbur A. Thomas CarrJiovascular Disease Risk Factors Transformation of Naturally Occurring Ouiescent fntimal Snwoth Muscle Cetl Masses into Atherosclarotic 33 tange. Eduard F. ation and Detoxicetion of Active Forms and Oxygen in Experirnerttal Athenoselcrosis. In Vivo and In Yttro Regule- I Lesions in Swine Fed Hyperlipidemic Diet tion of 3 •Hydroxy-3-iNethy, glutaryl-COA-Reducrase in Pbe n.._,--•---• - - - - - r.

134 Wurm. Heimut 135 Clopatfis. Peter Jnvesrigation of a Atew Apo- poprotein" in the Rat: Demonstration of a,-(3lyco- protein-t in all Major Lipo- protein Classes. MorphologJcal and Bio- chemical Studies During Atnerogenesis fn Swine. 136 Kohter. Constarce A. PlateJet Survival Time as an a e l 137 Sadava. David 138 Saito. Yasushi 139 Cho. Byung H. g . ar am index of Vascu Effect of Vitamin C on Rapid inductiori- of 1Atherasclerasis in Rabbits. Studies on Lipid Metabolism In Arterial Wall. Plasma Lipid Profiles. Hepatic Cholesterolgenesis and Aortic Lesions in Layer and Hereditary Nonlayer Chickens. 140 Chakravatti, R. N: Study of Spontaneous Atherosclerosfe in Wild Rhesus Monkeys. An EKpe- rience of 15 Years_ - • EPI®EMi®1.®Glf - i1 I illarco Polo Room ~ Chairoersons- ~ Nits H. Stenaby William Insuii. Jr. E ,e.MNA . First Author Titie ~ 141 tWaConathy. Mlsiter J. Cord Serum Lipids and Apolipoprofeins in PerinatJ - Disorders. ! 142 woidow. Asher a~fe~r~jsgi the Aged. 143 Coyer. Alan R. ~ 0e8th~m Cancer and Other Causes In Three Chicago BpJdemiological Studies.: 144 Heiss. Gerardo Detection of Type 11A Hyperlrpoprofeingma from Tolal Cholesterol Measure- menrs in a Pediatric Population: The Lipid Research Clinics Program (LRC). 145 Feigl, Walter Atherosclerosis in Mortality e Statish'cs. 146 Fordyce. Marianna K. Adipose Tissue Fatty Acid Compositiocr of Cretan Men With and Without Myocardial Inlarction (MI). vnd Their Children_ 147 Hailer, Hans Risk Factors in Oral Treated Diabetics. 148 Staheiin, Hannes 3. HDL-Cholesterol, Risk ~ Factors and LilaF Style in Families of a Working Population. 140 Shutman, Richard S. Peri-Inrercfion Changes in Cholesterol, HDL-Cholestero/ and Apolipoprotein A-l. 150 Ataupovic, Polar Plesmte-Apofepoproteilr Levels in Patients with Abetalipoproteinemia and Hypobetalipoproteinemie. DRUG EFFECTS AND THERAPY tff MAN-=-1I- nasrcea s Grove Ro Chair ons Ole Faerge n Fumlo Kutuys First Author Title 151 Wechster.~Jotf nes E3. DL-andLDL•Cholesterolin Pa fs with HyperlipidenNa Type IlA Trested With Different Lipid Lowering Drugs.

11 134 Wurm. Hetmut /nvestigation of a New Apo- 35 topath. Petet Poprotei.•r" in the Rat: Demonstration of A,-Giyco- protein-f in all Malor Lipo- l rotein Classes. Morphological and Bio- 136 Kohter. Constance A. chemical Studies During Atherogenesis 1n Swine. Platelet Survivat 7irne as an 137 Sadava. David index of Vascular Damage. Effect of Vitamin C on Rapid 138 Saito. Yasushi lnduction of Atherosclerosis in Rabbits. _ Studies on Lipid Metabolism i 139 Cho. Byung H. in Arterial Watl. Plasma Lipid Profiles, Hepatic 40 itakravarti, 1. N. Crrotesterolgenesis and Aortic Lesions in Layer and Hereditary Non/ayer Chickerrser . Study of Spontaneous c Atheroscierosis In Wild Rhesus Monkeys. An Expe- rience of 15 Years. • . EPIDEMIOLOGY - !i Marco Polo Room Chairpersons Amn«r. 141 Nits N. Stembyr First Auth,3r McConathy. Walter J. William Insult, Jr. Title - r Cord Serum Lipids and I ` 42 otdow. Asher ApoJipoPrCteins in Perinatal Disorders. Differentiai Diagnosis oi" ~ 143 Dyer. Alan R..~ Atherosclerosis in the Aged. Serum Cholesterol and Rislr of Death rrorn Cancer and 144 Heiss.-Gerardo 145 Feigi; Watter Detection Of Type 11A MYperlipOprOtelnemia from Totar Cholesteror Measure- ments irl a Pediatric PoPWation: The Lipid Research Clinics Program (LRC). Atherosclerosis in Mortelity / Statistics . 1448 Fordyce. Marianna K. . Adi t4i Hatter, Hans C~'mPosNion4 of Cret an Men WitA and Wfthout Myocard:al Infarction (1iAl). and Their Chitdren. Risk Factors in Oral Treated Diabetics . 148 St5hetin. Hannes 8. ~ HDL-Gholesterol, Risk Fai,tors and Lile-5tyle in Families of a Working Population. 149 Shutman. Richard S. Ppd-1 1 150 Araupovic, Petar Cholesteroi, HDL-Cho esterol and ApolrpoprOtein A-l. Plasma Apolipoprotein Levels in Patients with Abetalipoproteinemia and HYpobetalipoproteinetnte. DRUG EFFECTS AND THERAPY IN MAN - 11 Grove Ro Chair ons Ote Faerge an Fumio Kuzuya "°'" °ar First Authnr 151 Wechster I J h~ pitre o nes G. - n...... ,,. ; Ofher Causes in Three Chicago Epidemio/ogical 5tudiss. Pa-lBnfs with 1 /- r# TYpe ilA Treat~ w th ~demia L> Dillerent Lipid LOwering

I 144 tleiss. Gerardo Detection of Type ltk Hyperripoproteiiremia-Orom Total Cholesterol Measure- ments fn a Pediatric Population: The Lipid Research Clinics Program (LRC). Atherosclerosis,fb Mortality Statistics. 146 Fordyce.tlAarianna K. \ Adfpose j!(ssue Fatly Acid 147 Haiter, Hans ction (M!), and Their dren. Riskc _tors in Oral Treated. Diabeti HDL-Chol erol, Risk Factors and Ye-Style In Families of a rking Population. Perf-lnferction Cha es in Chholesterol. HDL-Cho sterol and Apolipoprolein A- Plasma Apolipoprotein Levers in Patients with Abetalipoproteinemia and Hypobetalipoproteinemie. DRUG EFFECTS AND THERAPY IN MpeP0 - s! . Grove Room Chairpersons- Ote Faergeman Fumio Kuzuya ac.&.a. First Author Title 151 UVechs3er. Johanruss G. HDL-and LDL•.Cholestero.'irt Patients with Hyperllpider+tle Type IlA Treated with Different Lipid Lowering Druos. Com h~rrt ol Cretan Men ith nd Without Myocardial I Awm 152 Yam- 153 ~ oto. Akira Therepeulic Effects of ML-236B on Essential wyp~cholestero/emia. t Tsuchi da, Tetsuya Primary Prevention of Ceretarovascuta Di 154 r sease - A Reporr of Eight•Year Trial. Schwatizkopff,-Wottgang The Etfectiveness of Lipanthyl in Comparison with C/olibrate Under L t 55 ong enn Thesapy in HPL Types llA. rIe and JY. Manninen, Vesa Ge f' m lb f 156 ror l and Plasma High Density Lipoprotein (HDL). Wechsler, Johanttes G. Lipids and Lipoprotefns in t r 57 Famiha/ HyperiipoproteinemJa (FH) During a Combined Drug Therapy. Kather, Horst The Human Fat Cell 58 Adenyfete Cyclase is the Common Effector System ol Antegnostic C9facholamine Errects Upon Lipolysis. Sailer, Sigurd Effect of Treatment on Lipo. 159 proteins in Patients with Diebetes Mellitus. jal Olsson, Anders G f 1 . Antiaggregerory F» ects of Ticlopidfne in Patier+.ts With Peripheral ; Atherosclerosis. ! 160 Oisson, Anders G. Dose Response Study of ~ Ciprolibrete on Serum Upo- proteins in i I Hyperppoproteinaemfa (HLPJ.

SMOOTH MUSCLE CELL - tI . AzAea Room 47ieirpiarsons Hanoch Bar-On Genju Ooneda .61 First At?thor Hauss. Werner H. 162 Hauss. Werner H. 163 Riinnemaa. 'i'apani +/ Combination on the Prolifer- Titki Effect of Risk Factors. Antirheumatic Drugs and Their Combination on the Proliferation of Arterial Wall Celrs. Effect of Risk Factorw Anti- rheumatic Drugs and Their 164 Scott-Burden. TirraMy 165, Stout, Robert W. 166 Pfeifle. geate 167 Chamtey-Campbell, Julie H. 164 dagdade. John OV ation of Arterial Wall Calls. Sera With Different LiRo- protein Compositions Influence the Synthesis of Glycosaminoglycans by Cultured Human Aortic Smooth Muscle Cells. Etastin 8iosynthesis by Smooth Muscle Ceps Under Scorbutic Conditions. Differential Effects of Serum and Hormones on DNA Synthesis in Cultured Endo- theial and Smooth Muscle Cells. . Effect of Insulin on 8rowtlt of Htinttcn Arterfal Smooth Muscle Cells !n Vit% Phenotype Modulation and Proliferetion of Aortic Smooth Muscle. Polyamines: Unrecognized Serum Mitogens which lnqu- ence Arterigt Smooth.iNuscle Cell Proliferation. i 169 Tate, Charlotte A. Temperature Dependent Alterations in pH Effects of Isolated Sarcoplesmic Reticulum. 170 Van Winkte, W. Barry Regiona/ Heterngeneity of L' Aeer.n. 171 ,prd-Calcium Atpase Comp/exes in Fast Sheletal Muscle Serpoplasmic Reticulum. THE ARTERIAL 1fVALL • li Bluebonnet Room Chairpersons Henry D. Hoif Richard E. Tracy First Author Subbiah. iiavi M. T. Title Altpred Prostaglandin Syn- thesis in Aorta and Platelets 01 Sponteneously Diabetic Wistar Rats. A Comparative Scanning Electron Microscopy Study of Human Uterine Arteries with Special Reference 10 Smoking. Myocardie/ end Aortia Lipids_ in Human. Prefereniial Accumulation of Proleog/ycensJn Endo- thelieim-Covered Neointifia After One Endotheifel 1nJury. Nonspeciffc Esterase Activity in Human and Baboon Aortic Lesions. - Apoproteins and FibNnogen in Surgically Excised AtherosC/erotlc Arterfas: Lipid Metabolism of Human Arterial Explants in Longterm Tissue -cuiture. Huma. Postheparin Plasma Lipolytic Activities Irrom the Sinus Coronarius af Pa#ients with CoronaryArtery Disease. 172 Bytock, Anders 173 Suzuki, Naoki 174 Richardson, Mary 175 Sprague, Eugene A. 176 Bradby. (00Nrey V. H. 177 Janssen, Edgar Jen 178 Augustin, Jan

11 179 2emptenyi. Tibor K. Major and Trace Element 188 Arntzentus, Alexander C. Results of Dietary instruc- 80 Content ol Human Aorta wrth Emphasis on Aortic Silicon. tadisFas Purification end Properties of Robert tions to 597 Hypercholes- r! terofemic Individuals. Con- t/ sultation Bureau Heart . Human Aorta Elastese Like Protease. 189 Project. Netherlands. i . Kohtmefer, Martin The Efiect of Lipid Lowering If Diets on Lipo rotein ®IET - II 190 p Composition. Hellstrdm Kjell The Eff 1 Venetian Room , ect of Cholesterol •,. Feeding on BileAcid Kinetics, Chairpersons Steroid Balance and Biir'sry Lipids in iVOrmoli id i Fted H. AAattson Jan J. Oppit thor Titte t A Fi p em c and Hyperh"+ceridemic Subjects. Abmees 181 u rs Morrison. John A. Nutrient lntake: Relationships METABOLIC ORIGIN OF with Lipids and Llpoproteins in B-t9 YeerOld Children: The i IiYPERLIPI®EIUIIA - II ct Princeton School Distr Study. Normandy A Room . 182 A Dietary Cause of Oster. Kurt A. i Chairpersons 183 Atherosclerosis. Brussard. J. H. Effects of Amount and Type .eu.me George D. Steiner Joseph L Witzum First Author Title of Dietary Fat an Serum Upids. Upoproteins and Apo- 191 Sakuma, Nagahiko Changes of Serum Lipopro- proteins in Man: A Controlled 8-Week Trial. 192 tefn in Hypovitamin C Atherosclerosis. Carroll. Kenneth K. Effects of Dietary Prorein on ! 184 Schne'rder, .lurgen Effect of Food lntake Distri- Cholesterol Metabolism in bution and Polyur?saturatedl Saturated Fat Ratio On 24 Hour Profiles. 193 Rabbits. Reardon, Michael Independent Production of Intermediate Density Lipo= ~ 185 86 Ftovrard. Alan N. The-Hypochoiestero/aemtc Factor in Milk. Cholesterol Tolerance Test: A Scdht, Harbhg;an S. ~ Novel Approach Providing 94 t protein Particles in Type itt Hyrperllpoproteinemia. I ®hattacharyya, Ashim K. Mechanism of Severe Hyper- cholesterolemia In High- ~ Evidence That Diet Induced Rise in Plasma Cholesterol , Responding Rhesus Monkeys Fed Cholesterol. tsDue to Change In Structure and/or Metabolism of Hepatic 185 jl Kfose, Gerald Disturbed Lipoprotein Cata- 8T' Lipoproteins and It is Not Due to the Presence of Remnants of Inetestinal Lipopr?teins. Gibney. MicFeel J. Soya. SaPonins and Serum 96 bolism and Abnormal Lipo- protein Composition in Pancreatitis. Middelhoff, t3ert Disturbed Lipid Metabolism Cholesterol. Secondary to Liver Disease.

I 197 Amer. Peter Uptake and Ester)ficatfon of Fatty Acids by Human Ad.j- pose Tissue in Hyperlipaemia. 196 Kupke. Ingeborg R. Lipids-andtipoprotelns-inthe- Rat. - Neonatal Aspscts In Controls and Diabetics. 199 Leijd. Barbro Cholesterol and Bile Acid Metabolism in Obesity and Hyperli poprotefnaernfa (HDL) Type IV. 200 lloumas. Jacques Metabolic Pathways of Hypo- lipidemic Drug Administered to Rats and Humans. Indenti- fication of -IVletabolites- in Physiological Fluids and Tissues. 9.®L METABOLISM - -[9 Nile Room Chairpersons Howard G. Margan M. John Chapman .C65,20. First Author 201 Haba. Toshihiro Title Low Density Upoprotein Receptor in Fibroblasts From Patients with Familial Hyper- cho/esterotemia in Japan. 202 Packard. ChrMopher J. Receptor Dependent Low Density Lipoprotein Cata- bolism in Normal and Familial Hypercholesterolemic Subiai,ts. 203 Nakada, Isao Scanning Electron Micro- 3copy of Familial Hypercho- lesterolemic Fibroblasts. 204 Weech, Philip S. The Magnitude of Metabolic Changes In the Density of Low-Density Lipoproteins in Man. 205 Valente. Anthany A Simple Atternative Tech- nique for the Demonstration of Specific Low Density Upo- protein Reaeptor Sites on Ceil +embrane. - 208 8ates, Sandra R. HDt. Reduction of Cellular Cholesterol Ester Accumu- latiOn Stimulated by Hyperlipemic LDi. 207 Schmitz; Gerd- LDL-Turnover and tipopro- tein Composition in Patients with Jejuno llaa/ Bypass. 208 Ulingworth, 0. Roger Cholesterol Syn;t:Osis in A beta/ipoproteinemi. i. 209 Houseman. Kathy . Lipoprotein Metabolism in Normal and Hypercholes- terolemic Rabbits: K,,?etic Analysis.- 210- Ghiselli; Giancario-C. D-uel Synthetic and Cetaboli„ PoOI o/ Low Density tipopro- lein A PO 8 in Normal Rabbits. HDL WIE'fABOI.OSM - IB Belvedere A Room Chairpersons Philip J. Barter Anne-Lise &brressan Aeiftaa. First Author Title 211 Nestei, Paul J. Cholesterol Kinetics In 212 Rao, Suresh N. Hyperalphalipoproteineemie. Plasma Apolipoprotein Al and All Kinetics in Hyper- triglyceridemia. 213 Magill. Patrick Relationships of High Den- sity Lipoprotein (HDL) Apo At and Apo Ali Kinetics to Very Low Density Lipoprotein (VLDL) Apo 6 Metabolism in Man. 214. Kay. Ruth M. Acute Effects of Dietary Fat Load Di3tribution on Plasma Hlgh -Densify-Lipoprotein - (HOL) Components. - 215 Assmann. Gerd Chylomicron Metabolism In Tangier Disease. I

t i r 216 Van Tol, Arie Dlstinction Between the T Fiaf f the Protein er es o 217 Miiier. George J. rotein Metabolism ii Li Gi o I' 218 8 i p ~tvanne p a agg ~ During Poatprandiel Phase: Relationship Between Very Low end High Density Lipoproteins. 219 Rossner, Stephan Serum Lipoprotein Abnor- malities in Critically lli Intensive Care Patients. 220 _ Waitdius, Goran Abnormal Cholesterol Distri- bution in Serum Lipoproteins in Patients +vitRAcute Pancresfitis. LIPOPROTEIN LIPASE - 11 - Nt-rmandy B Room Chairpersons David J. Galton ~x,o First Author 221 Kotze.Johan P. Ann-Margret Ostlund-Undclvist umov and Lipid Moieties of Serum High Density Lipoprotein. Separation of Plasma HDL Subclasses by a Simple Precipitation Procedure. Title Isolation and Characteriza- tion of Baboon Cardiac Lipo- protein Lipase.. Inhibition of Hepatic Lipase by apoproreins. Hydrolysis of Human VLDL TG on Vascular Surface of Rat Heert. Isolation and Characferiza- tion of Human Milk Llpopro- tein Lipase. Evaluation of Three Proce- dures for the Differential Determination of f.ipolytic Activities in Human Pbs!-Heparin Plasma 222 Kinnunen, Paavo K. J. 223 Wada. Kazunari 224 Wang, Chi-Sun 225 Wang. Chi-Sun .w f I n 226 Dashti. Nassrin Synthesis and Secretion of Lipoproteins by R8t Liver Cells in Primary Culture. 227 Appiebaum-Bowden, Effect of Heperin on Release Deborah of Hepatic Trigylceride Lipase. 228 Bensadoun. Andre Direct Solid Phase Radio- immunoassey of Chicken Lipoprolein Lipase. 229 Etienne. Jacqueline Purification of tipoprotein Lipase by Affinity Chrometog- rephy FolloweJ by Prepera- tive Eectrolocusing. 230 Schrecker. Otto Some Aspects on the Subunjt Str:rcture of Human Plasma Lipoprotein Lipoprotein Lipase. THROMBOSIS AND IMMUNE COMPLEXES - I Belvedere B Room Chairpersons Viofette Beaumont _ Isamis Salcurai .bmMO. First Author Title 00, Food Antigens and Experi- 231 Gallagher. Patrick J. ,/ mental Atherosclerosis. 232 Tanaka. Kenzo Cerebral Artery Thrombosis and Hypenensron. 233 Weigenaberg, Bernard I: Eflect of Circulating Factors From Thrombus on Choles- terol Atherosc/erosis in Rabbits. 234 Vijayagopal, Parekat Studies of Biological Pro- perties of Proteoglycans iroc ®ovitts Aorta. 235 Chakravartl, R. N. Selective Depletion of Fibri- nogen and tts Effect o`^t the Evolution of Cholesterol Atherosclerosis In Rabbits. 2W Ger& Sfindor= - Circulating =tmmatne Com-- pieires tn Myocardial tnrarction. 50 , i,.Wk _ .. t

i AL- 23T Horsch. A. K Immunologic Arterial injury in Rats and Swine. 249 Heu( k. Claus-Chr. Effect of Bicarbonate Hemo- i ~ 238 Moo{en. Ed. J. Coagu/erlon-Promot'n$ dia/ysis on Hyperlipemia in Diaiysed Subjects. i t ~ ~ Activity. 250 Oster, Peter Diurnal Lipid Profiles in t Renal Disease. ~ ~ RISK FACTOR llAO®iFICATION ~ Castiiian A/B/C Room Chairpersons I aemW. TedaQ Yasugi Hugh MaA. Taggart First Author Title 241 8[erenbaum. Marvin L Effects of Shorl- Term Treat- 42 obec'cy, Jitka S. ment of Post Coronary and Diabetic Subjects with High Levels of V'nemin -E. Nutrition Intake end Serum 243 , Tuomilehto, Jtiakko Cholesterol Level in Infants Six Months of Age. Reducing Complfcations of 244 Tuomilehto. J:3akko Hypertension In en Entire Cornmunity. Coronary Risk Factor 45 altentin. t.ers-C. Changes Ouring a Five-Year Community Intervention (The North Karellu ProJeCtj. Plasma! ipoprolein Metab- 48 smussen. inger olfsm During Estrogen pnd Antiandro®en Therapy In Men. Smoking Habits arnong Prep- 47 Roore, Riahe.M J. nanf Women - Its Clinical Consequences for the Next Gteneration. The Progratn on the Surgical 1i 248 H4etmerm Ingvar Control of the Hyperlipidemfe (POSCH). The Rendomized 'Sinodcirrg- , ~. Lipid T.rief°of the Oslo Study. ~~

ji ~ r ~I Ir PLENARY SESSION: " THE VESSEL WALL IN ATHEROSCLEROSIS 5:30_ a.m._-12:00 p.m. Grand Ballroom Chairpersons Jatnes F. Mustard Robert W. Wissier Participants Bengt Samuelson Michael A. Ginibrone Jr. Russell Ross The Platelet - Derived Growth Factor Salvador Moncada _ CONCURRENT WORKSHOPS: 1:30 - 4:aa p.m. : I FATI vim . T1111"URIAY ove ber 8th91979 NON-DIETARY, NON-PHARMACOLOGICAL TREATMENT OF HYPERLIPIDEMIA Marco Polo Room Chairpersons Thomas E. Starzle Gilbert R. Thompson Participants Thomas E. Starzle Surgical Approaches to the Treatment of tiyperlipidemfa E. A. Stein Portscaval Shunting for Homorygous Familial Hyp`srcholesterolemia Henry 8uchvvaid Treatment of Hyperfipidemia byParti®t lJeal By-Pass Tatu Mienttinen Comparison of Chofestyramine, lleal By-Pass and Portaceval Shunt in Familial Hypercholesterolemia G. M. 8. Berger Plasma Exchange in the Treatment ol Homorygous Familial Hyper cholesterolemia

W I Paul J. Lupien Selective aff nity Chova~~g aph~ PiasmB Giitiert R. Thompson for Famil H percho esterofemie~ I THE ARTERIAL WALL- !9- Grove Room Chairpersons Elspeth B. Smith Donald M. Small Participanls I DL: NEGATIVE RISK FACTOR FOR CHD Azalea Room Etspeth B. Smith Introduction: Transport of Macro- molecules Across the Artery Wall Henry Hoff Low Density Lipoproteins in Aorta: Relation to Atherosclerosis Chairpersons ' Fujio Numano Cyclic Nucleotides and Atheroscle- Fredric H. Epstein William P. Castelti rosis .F i yl. ~ . E. Bottinger Fredric H. Epstein harles J. Glueck Participants i Role of HDL in tndividual Prediction and Community Prevention of Cornnary Heart Disease Richard W. St. Clair Differences in the Metabolism of Ab- normal Low Density Lipoproteins from Cholesterol-Fed Nonhuman Primates by Cells in Culture`" Yoshida Hata Donald M. Small Synthesis and Suming up Tavia Gordon Norman E. Miller Epidemiology end High Density Lipoproteins HOL Cholesterol, Tissue Cholesterol nd Coronary Atherosclerosis: VESSEL WALL-PLATELET INTERACTION Bluebonnet Room a Epidemiological Correlations Chairpersons ~t= Hans R. Baumgartner Gustav V. R. Born 1 t CLINICAL TRIALS 1=mbassy Room Chairpersons William T. Friedewald Jeremiah Stamler Participants Hans R. Baumgartner The Role of F.VilliWilfebrand Factor in .p the lnteraction of Platelets with Subendothelium Gustav V. R. Born Do Platelets Contribute to Athero- ~I I Participants Wittiam L. Holmes R~ M. Knopp, Test of the Lipid Hypothesis: The Coronary Primary Prevention Trial (CPPT) of the Lipid Research Clinics Program Michael F. Oliver James A. Schoenb+HrgOr genesis taurence A. Marie®r Platelet and Shdotheldet Alterations in Experimental Arteriosclerosis C. Richard Minick Endothetlum and jFxperimental Atherosclerosis Michael B. Stemerman Smooth Muscle Celt Kinetics In dho: A Comparative 8tudy J! Salvador Monceda

1 i p: 253 Hoimes Ross P CATABOLISM OF LIPIDS, APOLIPOPROTI?IN5 AND LIPOPROTEINS Camellia Room 54 , . Griggs. Thomas R. Chairpersons DeWitt S. Goodman Paul J. Nestel DeWitt S. Goodman Participants Turnover and Metabolism of Body Cholesterol in Man 255 Naito. Herbert K. Paul J. Neste: David W. 8itheimer Scott M. Grundy Very Low Density Lipoprotein Protein Catabolism in Man Low Density Lipoprotein Metabolism in Man Kinetics of VLDL-TG Transport in Man i 56 inzinger, Helmut James Shepherd HDL Apoprotein Metabolism ` Allen Sniderman A Model for Reutilization of Cholesterol Ester Betwnen Human VLDL and LDL 257,_ Sinzinger, Helmut Donald 9. Zilverstnil Rote of Chylomlcrons in AtherogRnesis CONCURRENT ORAL PRESENTATIONS 258 4:00 - 6:30 p.m. 259 AIdIMAL MODELS OF -ATHEROSCLEROSIS - III , 13elvedere B Room Chairpersons 251 Rober! W. Mahtey First Asstitor Betlort, ErrW t,l}, Dieter Kramach Title The Utility of Arteriography In the Evaluation of Experi- mental Atherosclerosis: A Ten-Year Experience with Rhasus and Fascicularls ~earwu o - 269 252 Katocs. Andrew S J_r_ Monkeys. Reevaluation of the Balloon- 262 Catheter (BC) rnlury Model or Atherosclerosis (A). Rapacz, Jan Weecfi, Philip K. The Role o125-Hydroxy- vitamin D, in the Induction of Atherosclerosis in Rabbits by Hypervitaminosis D. Effect of Carbbn Monoxide Exposure on Endothelial Permeability end Aorric Cell Replication !n Normal and Von Wiliebrand s Disease Swine. The Relationship Between Dietary rnquced Hypencho- festerolemis, High Oensity Lipoprotein and Resistance tohN Atherogenesis in the Ground Squirrel. Proslacyclin Generation of Arteries of Miniature Swine. Decreased Prostacyclln Generation of Arteries of a Genetically Hypercholes- terolemic Strain of Rats (RICO). immunogenetic Poly- morphism of, Serum Beta- Lipoproteins In sonne. High Concentrations of Serum Lipoproteins In Cap- tive Gorilla Gorilla. EPIDEMIOLOGY - III Marco Polo Room Chairpersons Lars A. Solberg Shuichi Hatano First Author Kay, Ruth M. Nakamura, Haruo Tifie Relationship of Fat and Fiber Intake to Serum Lipids. HDL-Cholesterol In Humen Obese Subjects - Sumo Wrestler. en

264 Hanefetd. Markoif Coronary Risk Factors in Insulin Dependent Diabetes. 274 265 Brown. 8. Greg The Natural History of a - Coronary Lesion: A New Quantitative Approach to the Clinical Investigation of Coronary Atherosclerosis. 275 266 Montaguti, Ubaldo CHO Risk Factors in a Medium Sized Italian Town. 267 Tyroler, Herman A. Apofipoprotein A-t. A-li, and C-11 in Evans County-Black- and Whites. 276 2$8 Wieland, Heinrich A New Method for Measure- ment of Plasma-Lipoproteins: A Clinical Evaluation. 410 269 Lenzi. Sergio The Bristghella Study. A Six Y Year Follow-Up. 278 270 Stone. titeii J. Hypertriglyceridemia In Peritorreat Dialysis: Compari- sons with Hemodialysis. 279 263 BjSmheden. Tom G. S. DNA and Cholesterol in Skfr& in Young Survivors from Myocardial Intanstion. 280 Y DRUG EFFECTS AND THEFBAPY IN MAN - III !E Grove Room ~ ~ Chairpersons ~ 1lViFliam f1. Hazzard Richard B. Moore ~ xxVW• First Author Title 271 Stone.llAaurice C. The Response of Hyper- lipidemic Patients to Different . } i Doses of Clolibrate. 272 Wolfe. Bernard M. Clotibrate Inhibits Hepatic Triglyceride Secretion in ~ Glucose-Fed HyperVfglycerf- Wu.cu demic Men. 281 273 ( Marka. John Comparetive-Prted of tsemfl- { brozil and Clofibrate In Diabetics. Nash, David T. • Heuck. Ciaus-Chr. Haacke, Hartwig Tikkanen, Matti J. Metabolic Effects of Probucol arrd Cloflbrategn Dyslipopro- teinemia In Patients with Proven Coronary Artery Disease. Nicotine Mediated Effects ~ During Adrenergic Blockade with Respect to Plasma Nico- tine and COl-tb-Concen- tiations. Mechanism of the Hypo- triglyceridemic- Effect at- Biguanides. Effectiveness of Gemfibrozil in Clolibrate Non- Respondeq.Transport of NIMe:tine in Human Serum. Effect or Xantinol-Nicotinate on Lipids and Lipoproteins of Serum with Respect to Drug Dosage and Blood Levels of Nicotinic Acid. Progestin Treatment Influ- ences Plasma t.fpopro tein Concentrations and Postheparin Plasma Hepatic Upese Activity in Normal Women. SMOOTH MUSCLE CELL - 61i Azaiea- Room- Chairpersons Juiis i# Chartdey-CampbeiF First Author Habenicht, Andre9s J. R. Sandra R. 9ates- Titte Platelet Growth Factor tn- creases Cholesterol-Synthesis in CuiruneoNonkey Smootlr Muscle Cetls. J i

! ` 282 gjotkerud. Soren U. t , I Decreased GrowtOtCorttraFol Smooth Muscle in Athero= sclerotic Lesions May Be an Atherogenic Mechanism. THE AR3ERIAL WALL --011- Bluebonnet Room 283 Biornheden, Tom G- S. A System for the StudyRof Chairpersons 134 owyer. David E. Arterial rissue During Long Time lncubation Under Continuous lserifusian. Tangier Serum Lacks Ability AMMO. 291 Ladislas Robert First Author Bazanov. Evgenij A. Tadao Yasugi Title Collagen Fractions of Aorta to Promote Elllux of Choles- teryl Esters (CE) from Human Fibroblasts (HF) and Pig Aortic Smooth Muscle Cell (SMC) in Culture. . 92 urozumi, Takeshi and Protein Lipid Content of Plasma Lipoproteins in Rabbits with Different Degrees of Atherosclerosis. Permeation of Fibrinogen in 285 Fischer-Dzoga. Katti R. Response of Aortic Smooth I Coronary Artery of Hyper- 286 A4iam. Setiah Muscle Cells to Mechanical Iniury tn Vitro. Characterization of Cdlagen 293 Ehrhart. L. Allen cholestolermic and Hyper- tensive Rabbits. Synthesis e.nd Distribution of 87 edet, Thomas Synthesized by Cultured Human Aortic Cells from Patients with Aortic isthmus. Diabetic Serum. Growth 94 omita, Takako A. Polymorphic Types of Collagen in Canine Atherosclerosis. Aortic Cholesteryl Ester 89 tien, Julius C. Hormone, Insulin. and Synthesis of Type 1, Type fll Procollageft, and Glycoprotein from Arterial, Medial Cell Cultures. Regulatory Nature of Vascu- 95 hinomlya. Masaki Kydrolase Activity in the Rat: Sex-Related Differences and Fluctuations Due to Castra- tion and to Gonadal Hormone Treatment. The Regulation of Choles- 290 Avifa. Elba M. fer Smooth Muscle Membranes. The Role ol Surface Charge 296 Si:irai, Kohil terol Ester Hydrolysis in Lipid inclusion. Studies on the Relationship on the Interaction o! Lipopro-. teins or Apoproteins with Arterial Tissue and Isolated Arterial Proteoglycans. 97 ell, Frank P. Between L-ipase in Rat Arterial Wa/l and Serum-r+/oftspecitic Carboxyf Esterase. Inhibition of Adenine Nucleo- tide Transtocese in Arterial Mitochondria by Long-Chain AcylCoe and.Long-Chein Acylcernitine. r

301 302 304 305 306 307 308 309 11 DIET - oli Venetian Room _ - 310 Norbeck. Hans-Erik Low Relative Content of Lino- leic Acid in Uremic Patients Treated with a Diet Rich in Saturoted Fatty Acids. Chairpersons tsch Gert Middtet+otf f R J P . a ose F+rst Author Tift Descovich. Gialcarb Malinow. M. Rane Soya-Besn Treatment of Pri- mary Hyperlipoprofeinemz - A Muitricentric Trial. Reduction in Chotesterolemie Associated with Ingestion of ds Alf lf S GENETICS OF HVPERi.IPOPFtOTEitdERli6A -.Ji1 Normandy A Room Parry. Charles A. . a a ee I Significant Aspects of a Study Covering the Last Thirty Years of Research Into Major bur.a. Chairperson6. W. Carl Breckenridge Sigurd Sailer First Author Title ' Factors in the Etiology of 311 Janus, Edward D. Studies of Apolipoprotein B Fragiacomo. Claudia Cardiovascular Disease. Anafysis of the Lipid Lower- ing Eflect. Lipoprotein and Homonel Modifications 12 Kinetics in Genetically Defined Primary Hyperlipidaemfas. Dahten, G69ta H. E. Insulin Glucose and Lipid ubba. Paolo Following Soybean Treatment. Changes in Plasma Lipopro- 13 , , Levels in tndividuals with Different LP Phenotype. Pinon. Jean-Claude P. Plasma Llpoprotein Distribu- teln Composition in Patients with Marked Hyperlipidemia on Ljpid Lowering Diet. 14 tion and Composition in a Patient with Analbuminemia. Angelin, 8o A. Bile Acid Metabolism in Contaldo. Frnnco angiorgi, Zina Changes in Plasma Lip:pro- tein Composition in Massive Obesity After Weight Loss. Lipid Metabolism and Fruc- tose: Short Term Lipid Lower- 15 Familial Hypercholesterolemia: A Study Comparing Affected and Non-Affected Siblings of Two Kindreds. Kashyap. Moll L. Apollpoprotein C111 Defi- R6ssner. Stephan ing Effect ol Orat Loading. Relationship Between HDL and the Intravenous Far Tolerance Test. 16 o ciency in Triglyceride Rich LipoproleMs in Type V Hyperlipoproteinemia. Berg. Kere LP (a) Phenotypes. OLher Catvert, G. Dennis Double-Blfttd Crossover Study Shows No Effect of Soybean Flour. irrespective of Saponin Content, on Plasma Cholesterot. 17 Lipoprotein Parameters, and a Family History of Coronary i Heart Disease in Middle Age,+ Metes. Schaefer. Hans-Eckert LipidStorageandAtheroscle- rosis in Tangier Disease. i

I 318 Capurso. Antonio Measurement of ApoC-!l. 19 ranceschini, Guido ApoC-tH and PHLA in Three Families Affecterd with Pri- mary Type V Hyperfipo- protelnemia. Characterization of an Anorn- 20 obertson. Forbes W. alous High Density Lipopro- !ein in a Family with Hyp~r- triglyceridemia and Hypoalphacholesterolemia. Genetic and Environmental Variation of Lipoproteins. i LOL STRUCTURE - IIB Nile Room Chai!persons nen..a. Gunnar Sigurdwon First Author William A. Bradley Title 321 Chapman. M. ,lohn Characterisation of the. 22 lofsson. Sven-+?iof Trypsinreleasable Surface- Exposed Protein of the Human-Serum-Low-Density- i.ipoprotein. isolation and Partial Charac- 23 im, Hak-Joong terization of a Polypeptide Belonging to APOB from Human Plasma Low Density Lipoprotein (LDL). Non-Enayfnatit: Gfycosyl- 324 Chen. Tsung-Chang. eCion of Low Density Lipoprotein. - Binding of the Chemical Carcinoyen, p-Oi- Methylaminoazobenzene by Human Plasma Lipoproteins !n 1IlP% 32S Leggner. Peter Studies on the Surface Structure and Solvation of r -- rfsriaifv ZinoDfoteln. 326 Forfnaziuk, !litaiii-E. Sltedies_onlhe-B1ood Lipa- 27 rempler, Franz protein Structure Under Experimentaf Atheroscferosis by Means of Fluorescent Probes and Light Scattering Measurements. Lipoprotein LP (A): Is It a 28 ahien, Gdsta H.E. Metabolic Product of Other Lipoproteins Containing Apoprotein B? Structural.and Biological Properties of the Human Plasma Lipoprotein LP (A). 329 Wulfert, Ernst Specific Precipitation of Apo-$ with Concanavalin A (Con A) in Whole Serum and Isolated Lipoprotei'n Frac- 330 Goldstein. Sonia tions. A New Routine Method. Mole of the Carbohydrate Moiety in the Immunological R i i v eact ty of Human Serum Low-Density Lipoprofein: A Radioimmunologicel Study. HDL METABOLISM - III Belvedere A Room Chairpersons Allan Sniderman Alberico L. Catapano AbIVW . First Author Title 331 McLean. Larry R. Mechanism of Cholesterol Exchange. , 332 Koschinsky, Theodor High Density Lipoprotein 33 uusi, Timo Metabolism in Skin Fibro- blasts from 4 Patients with Hyperalphalipoprotefnemia. Inactivation of Heparin- ~ Releasable Hepatic Lipase by Specific Antiserum Influ. ences Rat Plasma Low_and_ High Density Lipoproteins In VIvQ. i I I

I .` 334 Ysrn3da. Shiro r a t t e 935 BaRer, Philiip J. 336 Ose. Leiv 337 Julien, Pierre ~g gl8rresen. Anne-Lise 339 Bachorik. Paul S. 340 Vessby. Bengt VLDL #AE'TABO9.ISM • III Normandy 8 Room Chairpersans - Jonas Boberg t3iovanneisa Baggio UMS0e First Author Title 341 Gibson. Joyo3 C. Trfglyceride Turnover in Regulation by lnsulin of High Density Lipoprotein or Apo- lipoprofein A-1 Swithesis 1n Primary Monofayer Culture of Adult Rat Hepatocytes. Transfers of Esterified Cholesterol Between Human LDL and HOL. Binding. Uptake and Degra- dation of High Density Lipo- protein in Rat Liver Cells. Characterization of Cardiac Lymph Lipoproteins in Dogs. Serum Reserve Cholesterol Binding Capacity (SRCBC): The Aetative Importanae of Different Lipoprotein Classes. interaction of High Density Lipoproteins with Isolated Porcine Liver Membranes: Evidence for More Than One High Affinity Site. Reduction of High Density Lipoprotein Chclesterol and Apolipoprotein A-l by a Lipid Lowering Diet. Chronic Renal Fatlure After Renal Transpfantation. 342 Yoshimine. Ploboru 8tudes on the Correlation Between Postheparin LJpri- protein Upase and Heparin Heaarinase. I 343 Nakai, Tsuguhiko 344 Dewailly. Philippe 345 Wirth. Alfred 346 Kather. Horst 347 Augustin, Jan 348 - Olsson, Anders G: 349 Pateiski. Jerzy- 35C Walldius,Giiran Regulation of Hepatic Triglyceride Lipase by Insulin -in -Rat. Diuririal Patterns of Plasma Glucose. Triglycerides. Free Fatty Acids. Cholesterol and Apolipoproteins in Normal Subjects on Regular Feeding. Beta Cell Function in Hyper- lipidemic Patients with Renal Insufficiency. Fat Tissue and Obesity: Age- Associated Changes of Responsiveness of the - Human Fat Cell Adenylate Cyclase Towards Peptide Hormones. Composition of In Vlvo Catabolized Human C.'sylomicrons. Starch Elock Electroptroresis of Late PreQ Containing Very Low Density Lipoproteins. Effects of Alimentary Lipaemia and Polyenylphosphatidylcholine on Lipase Metabolic Activity of Serum. Increased Fatty Acid (FIAT) and Glucose (GLlAT) lncnr- poration Into Human Adipose Tissue During Nicotinic Acid Treatment. PLATELETS Card Room ^ Chairpersons Gordon Cempbeti Ryszard J. Gryglewski

wa.M.n. First Author 351 Bierenbaum. Marvin L. Title tncreased Platetet Aggrega- lion and Decreased HOL Cholesterol in Women on Oral Contraceptives. 352 Bylock. Anders Early Reaction of the rlortic Wett and whe Blood Elements Following Deendothetialization. 353 Kumpuris. Andrew G. Detection of Post-Euercise Circulating Platelet Aggre- gales in Coronary Patients. . 354 Do Marinis, Milena Circulating Platelet Aggre- gates: A Chronic Platelet Activation in Patients with Transient Ischemic Attacks. 355 Waiter. Erhard E. Prolonged Action of Sullinpyrazone on Plate/et Aggregation and Induction of Drug Metabolizing Enzymes. 356 6oberg. Merike Platelet Aggregation Inhibition Produced by Ticlopidine. 357 Lewis. Jon C. Binding and Uftrastructural Localization of Low Density Lipoproteins on Thrombocytes. 358 Giansante, Carlo Platelet Aggregation end ""Other Laboratory Parametera" - in Diabetic Children and in Children of Diabetic Mothers. 359 Tremoli, Eiena Effects of lndobulen on Aggregation and Malondialdehyde (MDA) Formation in Platelets from Hyper and Normocholesferol- emic Subjects. 360 Walter. Erhard E. Platelet Function and Risk Factors in Patients of a Reinfarction Prevention Trial with ASA. Placebo and Phenprocoumon. - .:, REGRESSION Castilian A/B/C Room Chairpersons ll Absh-,a. Robert H. More First Author Ronald M. Krauss Title 361 Simons. Leon A. Failure of Cholesterol- 362 Sasaki. Norihiro Lowering Therapy to induce Atherosclerosis Regression. Studies on Regulation of I 1 ~ i 363 64 Fritz, Katherine eichl. Drago Cholinephosphotransferese Activity in Arterial Wall: CeH Types in Early Stages of Regression of Swine Atherosclerosis. Appearance of Tissue ~ Cholesterol in Lipoproteins of 365 ChakrBvarti. R. N. Peripheral Lymph in Man. ' Effect of Polyunsaturated Fat I i ~ end Low Fat Low Caloric Diet on Reversibility of Experi- mental Atherosclerosis in Monkeys. i 366 Oster, Peter Regression of Athsroscle- 67 e Gennes. J. L. rosis in a 12 Year Old Boy with (Homozygous) Familial Hypercholesterolemr'a. Lipoprotein Changes After 88 dams. Colin W. M. Portocaval Shunt Procedure in Four PBtients with Homozygous Type i'ta Familial Hypercho- lesterolemia. Cholesterol Solubilization by i 369 Moutafis, Costas D. High-Density Lipoprotein. Regression anA Progression t ~ of Xanthornas in Children with Homorygous Type il Hyperllpoproteinemia. I ~ 370 Jain. A. C. Regressive Effects of GaNic __ Oil on Cholesterol Induced Atherosclerosis in Rahhilc

iF4®i : NEGATIVE RlSK FACTOR -110 379 Canzler, Helmut No'Prevention of Coronary Heart Disease in -Farasuial Cameilia Room Combined Hyperelphe- and Hyperbetalipoproleinemia. Chairpersons 380 Hntt. Voiker The Influence of the LP (A) Li rotein an the C o n Aav,w. 371 Gerhard M. Kostner First Author Nash. David T. George Miller Title The Elfect of Brnwer's Yeast p p or po- sition and Cholesterol Concentration of the HOL- Density-Cless (1.063-t..25) in Different Types of Hyper- 72 ihari-Varga, Magdoina Containing Chromium Rich Glucose Tolerance Factor on Serum Lipids. In Vivo and In Vitro Corre- lipidemia. 373 Brunner, Daniel fations Between HDL and Coronary Disease. Cholesterol. Triglycerides 74 essel. Louwrens W. and High Density Ltpoprotein Cholesterol in Ischemic Heart Disease Patients -and in Healthy Persons. High Density-Lipop.olen _ CholestgroL Tiiglyceride and Apolipoprotein A1 Levels In a Dutch City. Monthly Variation and Association with Card1fovascular Risk Factors. 375 Mordasini. Rubino Abnormal Apo-A- 78 ' upke, ingaborg R. Composition in Patients with Angiographically Docu- mented Coronery Heart Disease. Serum and High Density 77 ager, Gunnar Lipoproteln (HOL) Lipids In Young -Men and 1Nomen, Microanalysis of Various Lipids. Apollpoproteins and I 378 9andJsrs, G&an Myocardiaf fnfarction. Cholesterol Elimination from Hurrisn Afterisl Tisslee--- t?tfects of HDL and Apo A-t Recombined with Phosphativyf Choline. I i

i @'rD A IFOR ATIO F1 AY - November 9th, 1979 .• PLENARY SESSION: PLASMA LIPIDS, LIPOPROTEIPlS AND ATHEROSCLEROSIS 8:30 a.m. - 12:00 p.m. Grand Ballroom Chairpersons Angelo M. Scanu Daniel Steinberg Participants Antonio M. Gotto, Jr. Lipoproteirr Structure Yechezkiei Stein Merabolism of Plasma Lipoprateins Joseph L. Goldstein Heiner Greten Robert W. Mahley CONCURRENT WORKSHOPS: 1:30 - 4:00 p.m. MUTANTS AFFECTING LIPOPROTEINS AND APOPROTEINS Bluebonnet Room Chairpersons Gerd Assrnan J. Alick Little Participants Gerd Assman Introduction to Tangier and Abetalfpoprote/nemfa H. Bryan Brewer, Jr. Tangier Disease Peter N. Herbert Abetalipoproteinea+fa and Hypobetaffpoproteinemfe J. Atick Little Introduction to Deficiencies of Apo- Ifpoprotein C-ll and APO E Ifl with some Associated Clinical Findings W. Cart Breckanridge Apolfpoprotein C-ft Deficiency G. Utermann APO E-flf Polymorphism

THE INTER-RELATIONSHIP BETWEEN LIPID AND PROSTAGLANDIN METABOLISM Grove Room Participants Chairpersons rin l Ch D li Sune Bergstrom G. S. 8oyd Anrrn V. Chobanian g u anges Aortic Fndothe a Development and Reversal of Participants Errperimentat Hypertension Ryszard J. Gryglewski Prostacyclin and Atherosclerosis - A Hypothesis Yuichiro Goto Laragh John M Renin Sodium Profiling and Vaso- Kafait U. Malik Modulation by Prostaglandins of . constriction Volume Analysis of Vascular Reactivity to Andregenic Hypertensive Patients. A New Era for StimuU Diagnosis and Treament Salvador Moncada Richard Lovell Controlled Therapeutic Trial in Mild Hypertension - Initial Results Rudolfo Peoletli Prostaglandins, Thrombin Receptors Philippe Meyer Clinical and Pathogenic Relevance of and Platelet Aggregation in Normal Erythrocyte Cation Fluxes Measure- Hypercholesterolemic Subjects ment in Human Hypertension Bengt Samuetson HYPERTEAISIOIV Marco Polo Room Chairpersons John M. Laragh Jerry R. Mitchell REGRESSION Embassy Room Chairpersons David F. Blankenhorn Jack P. Strong Participants - Mark t_. Armstrong Regression Sequences After Experimental Atherosclerosis Henry Buctnaatd Thomas B. Clarkson Assaad S. Oaoud Regresston of Advanced Atheroscle- rotic Lesions In Swine C. H. Stary Differences fll the Degredatfon Rate of tntracellular Ltpid Droplets in the intenat Smooth Muscle Cells end Macroph~eges of Regressing Athero- sclerotia Lesions of Primates- Robert W. WisBler CELLULAR METABOLISM OF LIPOPROTEIItIS Azalea Room Chairpersons Edwin !.. Bierman Nicholas Myant Participants Alan M. fogelman The Scavenger Pathway in Human Monocytes-Macrophages George H. Rothblat Chofesrerol Flux in Hepatome and 1•lepatocyte Cells:- tnfluence of d.CA T and Serum LPpoproteins Olga Stein DePosition end Hydnofysis ol Cyto- plasmic Triglyceride and Cholesterol Ester in Aortic Smooth Muscle Ceils in Culture. Ganiel Steinberg Edwin L. Bierman - Concluding Rer»arks: The Role of Hormone Associatad with Athero-- genesis in Modulating Cellular Metab- olism in Lipoproteins

APOPROTEI N QUANTIFICATION Cameifia Room Chairpersons Petar Alaupovic OieirPch Seidel Participants Peter Alaupovic Standarditation of Apolipoprotein fmmunoassays by an Isotope Dilution Method Gustav Schos>feld Ouenlitation of Apolipoprofeins C-I( end C-Ill in Plasma Marian C. Cheung Methodofogicaf Considerations in Apolipoprotein Irnmunoassay Pietro Avogaro Plasma Levels of Some Apotipo- proteins in Human Atherosclerosis Ncet H. Fidge Ouanfifation of C Apolipoproteins Metabolism in Human Subjects Dietrich Seidel Nephelometry of A-I and Efectrophoresis CONCURRENT ORAL PRESENTATIONS 4:00 - E:30 p.m. ANIMAL MODELS OF ATHEROSCLEROSIS -1V r=mbassy Room Chairpersons 0 384 Rapacz. Jan I 385 T li El remo . ena 386 Norbeck. Hans-Erik ' 387 Knipping. Gabriele 388 , Pagnan. Antonio 389- iLasmstrug. Oie- 390 Kamslrup. Ole Abefffla 381 s C. Richard Minick First Author Muller. Klaus R. isao Nakada- Titie i Endocrine Regulation of 391 382 Weber. Giorgio Serum Lipoprotein Concen- trations in'the Mate Ret. Some Uttrestructurat (SEM 392 and TEM) Aspects of Aortic Lesions During Chotesterol Atherogenesis Under the. 393 383 Baumgartner. Hans R. - Influence of GAG. Intimal Thickening Causes Yasooonatriction. P Arterial 1Nlmal Lipidosis. Fibrosis. Serum Lipid Concentrations-and lmmuno-- genetics of Serum 8eta- Lipoproteins in Swine. Metformin Reduces Platelet Sensitivity to Aggregating Agents in Hypercholesterol- emic Rabbits. /ncreased In Vitro Lipolysis in Adipose Tissue of Urelnic. J Rats. :so/atlon and Characteri- 3ation of a LP (A) Anaioyous Lipoprotein in Swine. Serum Lipoproteins and Atherosclerosis in Hyper- tens+ve Broad Breasted White Turkeys. Exposure uf Rabbits to S PPM- Carbonyl Sulfide. No Effect of Chronic Renal Failure on the Concentration of Free and Esterified Chores- terol in the Aortic tNall of Cholesterol-Fed Rabbits. WS4t FACTORS IN CHILDREN -111 Marco Polo Room Chairpersons Hans Fialler Neil J. Stone FirstAuthor- Title Laskarzewski, Peter Relationships of Measure- ments of Body Mass to Plasma Lipoproteins in School Children and Their Parents. Hatano, Shuichi Cardiovascular Risk Factors of Middle-School Children in a Japanese Mountain Village. Voors. Antonie W. Correlates of Blood Pressure During Childhood In a Total Biracial Population - The Bogalusa Heart Study. I

Asmussen. fnger Diabetes ldgelTrtus - A Risk Factor Acting Br,fore Birth. Ulrrastructural Studies ol the Umbilical Artery at Birth. Asmussen. fnSer Tobacco Smoking - A Coronary Risk Factor Acting Before Birth. Ulerastructural Studies on the Fetal Cardio- vascular System at Term. 396 Anyanwu. En)-eribe Coarctatio Aortae. Risk Factor in Children for the Development of Arlerioscle- rosis. 397 Webber, Larey S. A Persistence in Ranking for Cardiovaseular Disease Risk Factor Variables in Children. 398 Widhalm, Kttrt M. Age Dependency and Tracking of Serum Lipids end Lipoproreins in Healthy Children 11 to 14 Years of 399 Age. Plasma Upid end Upoprotein LeYels at Birth in Naples. DRUG EFFECTS AND THERAPY IN MAN - I!i 405 Mordasini, R. The Effect of Probucol and Diet on Serum Lipids and - Lipoprolein-Fractions. 406 Oriente. Pasquale ., Lipoprotein Patterns and 407 Oster. Peter Lipolioytic Activ€ty Modifl- catn Alter tntravenous Administration of Glycuronil Glucosamino Glycan Sulfate (3GS°). Diurnal Plasma Lipids and Ltpopruteins in lVormal and Hypenrrglyceridemic Subpcts wtth Liprd Lowering Therapy. 408 Frareceschini. Guido G. TiadenaJ Trcaaeeent in Type IV Hyperfipdderrria VLDL Modotication an Basal and Fntctow Ennt:hed Drsrs. 409 Wahlbecg. Gustaf K. Human Adipose trssue 277 Wu, Chun-Ctiung Grove Room ~ l:hairpersons So Angelin Elena Gerasimova .t=&,n. First Author Title 401 Endo. Akira The Cholesterol Synthesis lnhibifor ML-238B: Discovery to Preclinical Trials. 411 402 Tamai, Toshitaka Effects of Glibenclamlde and Insulin on Plasma High 412 403 Csogor. Stephan f. Density L/Qoprotain in Diabetics. Cholesterofuria. 413 404 Einarsson, N:urt A. Hepatic HMG ~Co-A- Reducfase Activity In Nonno- and Hyperllpoprotelnende: Etfects-of Si/e Acid Treatment 414 and Cfofibrate Therapy. Lipotysis During Treatment with NrCtltmlC Acid. Treatment of Hyperlipafemx Subiects with Long Acting Ear Acupuncture. ENDOTHELIAL CELL - IV- Azalea Room Chairpersons Thomas L. Innerarity Yoji Yoshida First Author Title Blhari-Varga, Magdolna Glycosatnlnoglycans of Endothelfal Cells. Nakanishl, Masato The Role of Lipfd Containers for Regression of Athero- achferosfs. Hayashi, Katsuhiko Changes of Aortic Endo- thelial Cel/s with Hypovitamin - C. A Scanning Electron Microscopic Study. Haneson, faOfan K. Plasma Proteins and Endothelfal Inium. I il

415 Moore. Sean Lipid Accumulation in Aortic Wall in Response to One Balloon Removal of ,Endothelium. 416 Burk, Robert P. Diagnosis of Atherosclerosis Using Tissue culture? 417 Izumida. Hide6 i Morphological Change of Arterial Intima Caused by Lipid Peroxide. 419 Levesque. Murina ,i. Mlcroscopic Examination-of the Arterial Endothe/ium Using Vascular Casts. 420 Coetzee, Gerhard A. Uptake and Deg.radation of Low Density Lipoproteins (LDL) by Coniluent, Contact Inhibited Bovine and Human Endothelial Cells Exposed to Physiological Concentrations of LOL. 425 Comhill, J. Fredrick Endothelial CeU Morphology at Aortic Flow Dividers. 426 Bomberger. Richard Effect of Hypercholesterol- emis on the Evolution of Aortic Microinjuries. 427 Adams, Colin W. M. Tissue Reaction tat3xidized- Derivatives of Cholesterol. 428 Robert. Ledislas Interaction Between Lipids and Arterial Wall. 429- Wight. Thomas N. The-Effect of Growth Stimae- fation on GlycosaminoglXcen Synthesis by Arterial Smooth Muscle Celts. EXERCISE AND DIET - IV Card Room Chairpersons Kenneth K. Carroll Wemer H. Hauss o, Aew..o+ Fin3t Author Title 431 Lehtonen, Aapo Physical Activity and HDL. 432 Frank-W: Booth pt-Exercrsing. LOngevlty THE ARTERIAL WALL - Id. . , Corpulent Hypertensive Rats. I 433 NJirth, Alfred fatty Acid Composition in Btuebonnet Room Chairpersons 434 Lithell, Hens Physically Trained Rats. Relationship Between Lipo- it f A ti i Li I aa.eaew 421 H. C. Stary Henry F. Hoff First Author Title Campbell. Gordon R. 'Spontaneoua' lnfimal Loss 38 escovich, Giancarlo v y o pase c prote n- Skeletal Muscle and Body Weight. Long-Term Treatment of !i " P i and Medial Smooth Muscle Ce11 Proliferation In Arteries of Hypertensive Rats and Rabbits. 37 chrott. Helmut G. Primary Hyperlipopro- tninemia with Soya-Bean Rroteins. Lipoprotein Changes in 422 Ghosh, S. Transport Across Aortic Wall: Massive Weight Loss. ~ Selectivity and Porosity. ~ 423 Daiteres Edward R Jr Studies of Glycoproteins 438 Diehl. Hans A. Short Term Results of 424 ., , . from Bovine Aorta. Aspen Anita .. Disruption of Microtubules Pritikin's Residentiel Multiple Risk Factor Modification Program for the Treatment of ! . end its Rote in the Sup- Dression of Atherocenesis. • ASH6, Hypertension and Diabetes_

454 tzaata. Masahiro 455 t+tiiausen. M'.arin 456 Henze, Kurt 457 Pitas. Rotert E. Preparative and Ouanti tative rsotation of Plasma Lipopro- reins by Discontinuous Density Gradient iJitraten- trifugation in a Vertical I?otot: Title Sietic Acid Content of LDL Controls Bindingand UptaRe- by Cultured Celrs and Cellular Cholesterol Metaborssm. Interaction of Normal and Hypertrigtyceridemic VLOL with Cultured Normal Human Fibroblasts. Properties of Cholesterol Ester Hydroleses in Arterial Tissue. Relationship Between Acidic Glycosaminorlycan -in -Lipo- protein Fractions by Ultra- centrifugation and Arteriosclerotic Diseases. Ettecf of Phytohemaglutinih and Low Density Lipoprotein in SterolSynthesis by Freshly Isolated Lymphocytes. The Effect of Hydrocortisone on LDL Binding and Degra- datfon by Homan Skin Fibrob/asta. Oirnyristoytphosphatid yl- choline (DMPC) Apo-E Complexes Provide Evidence for Multiple Receptor Binding of Aco-E to FiDroblasts. I LIPOPROTEIN METHODOLOGY - 11! Normandy A Room Chairpersons Gary J. Nelson Richard L. Jackson Abw.a. 441 442 First Author Mitis, Gervase L Ozerova; Irina N. _ Title . Microanalysis of Serum Lipoproteins. L-ecithin-Cii9iesterol Acyl-- f i ~ i - transferase Activity and High Density Subtractions Lipid Composition in Men with Hyperaiphailpoproteinemt'a. 443 Takamatsu. Shigeru LCAT Activity In Cerebro- 444 Bode. Gunter vascular Patients. ldentilication and Characteri- 445 Weech, Philip K. aation-ol Cholesterol Cr_vstals in Human Plasma. Semi-Micro Procedures for 48 odhi, Hartihe}an ~ the Isolation of Lipoproterns from Serum, Specified by Their Apolipoprotein Content Comparisorrof Plasma- 1 Concentration of HOL and Activity of Plasma Lecithin i ~ 47 alientin, Lars C. Cholesterol Acyltransferase in Normals and Patients with Coronary A.-tery Disease. Lecithin: Cholesterol Acyl ~ Transfer Rate and HOL in ~. 448 WaBeMin, Lars C. Coronary Atheromatosis. Plasma Lecithin: Cholesterol j Acyl Transfer Rate in Rslation to Bile Acid Formation and a ~ 449 Heuctc, Claus-Chr. Net Steroid Balance in Type IV Hyperiipoproteinemia. /mmunonephelometric Properties of Human Serum Lipopsoteins. j~

458 Harmony. Jud th A. K. Low Density Lipoproterns (LDL) lnhibit Calcium Ion and CycYc Nucleotide Accumu- lation 6y Mitogen-Stimufated Lymphocytes. 459 Craig. lain F. Cholesterol Rich Dispersions - A New Method for Labeling Lipoproteins. 460 Sigurdsson. Gunnar Effect of Co/estipol Hydro- chloride on the Metabolism of Low Density Upoproteins on -Hyparbetalipopro-- teinaemia. APOPaiOTEIN STRUCTURE - IV 468 Hancock, William S. The Analysis of C-Apolipo- proteins Obteined I ••m Human VLDL by Hi,fh Per- formance Liquid Chroma- tography. 469 Kostner. Gerhard-M: Sublractionation-of-HDL Using Heparin-Sepharose: Investigation of Minor Fractions. 470 Bradley, William A. Enzymatic Mapping of the Polymorphic Forms of Apo- lipwrotein E from -Human - Very Low Density Lipoproreins. LIPOPROTEIN LIPASE --IV - Belvedere A Room Normandy B Room Chairpersons Chairpersons John D. Brunzell Andre Bensadoun Peter N. Heriart Maryvonne Rosseneu e"K,. First Author Title OL"B"affo First Author Title 471 Keshyap, Moti L. Lipoprotein Lipase Delicien 461 Lee. Diana M. Solubility and Other cy and Apolipoprotein CN Properties-of Human Apo - Low Density Lipoproleins 472 Metabolism. Groot, Pieter H. E. The Fate of the Phospholipi 462 Kanazawa. Taiemichi Isolated Under a Mimic Anaerobb; Condition. A Study on Water-Soluble " Moieties of Rat Very Low Density Lipoproteins and Chylomicrons During In Vitr 463 Polz, Erika Lipoprotein. tnvestigailort of p,-G/yco- Lipolysis by Purified Bovine Milk Lipoprotein LipBse. protein-I In Normal and in 473 Glick. Jane M. Inhibition of Lipoprotein 484 t3uo, Luke S. S. HyperrrlgJyceridemic Persons. A-I Apolipoprotein of 474 Lipase Synthesis and Releas In Cultured-Preedipocyles. Desei, Kappu S. Saturable High Affinity 466 Bausserman. r.irtde L. Guinea Pigs. Serum Amylald Related Binding of VLDL to Adipocytes. 67 oimquist Leli T Proteins of High Density Lipoproteins. Quantitetion of Human 475 Catapano, Aiberico L In Vitro Lipolysis of Very Low Density Lipoproteins in a Case of ApoC-1l Deficienc I , . Serum Very Low DensityApo- 476 Erkelens, D. Willem CIl/Ct/t Ratio of Transferabl llpoprotein C-1, C-11, C-1lf and E by Enzyme Immunoassay. Apolipoprotein In Nonlipomi Plasma.- I ft

---•~--- 0 ' 477 I Jensen, Hans Heparin-Refeasable Liver Lipase In fsolated Rat Liver u C 487 Sinzinger. Helmut The Importance of Dillerent Prostacycfin Synthesis by V i f T i i 478 e s. Fitzharris. Thomas J. Lipoprotein Lipese fLpL)- Catafyzed Hydrolysis of Guinea Pig Very Low Density Lipoproteins (GP-VLDL): Correlation with VLDL Cll 88 ar ous ypes o Human Atherosclerotic Lesions for Perpetuation Progres- sion of Atheroscierosis. Ribeiro. Lair G. T. Pnastacyclln in Experimental i Coronary Artery Occlusion. I ` Aad C111 Content. 489 Andrassy, Konrad Antiplatelet Action of 479 gjamtorp. Per A. The Development of Lipopro- Penicillin. rein Lipase in Adipose Tissue. 490 Otsson. Anders G. The Effect of Intravenous 480 Gallon. David J. Hypertriglyceridaemia Asso- Prostacyclin in Per:pherat ciated with an Abnorsrtal- Triglyceride-Rich Lipopro- tein Csrrying-Eitcess - -- 'Apolipoprotein C-tll-2. Artery Disease.- .I 7 PROSTAGLANDINS - 11r RISK FACTOR SYNERGISM Castilian A/B/C Room Belvedere B Room Chairpersons Chairpersons J. Paul Miller Richard S. Shulman v Kafait V. Malik Zvi Freedman First Author ' Titie w bolmo. 491 First Author Title Tataml. Ryozo Intermediate Density Lipo- 482 Kaiimsn. Josef Prostacyclin Generation by protein (1DL) in 483 Human Forearm Veins in Peripheral Vascular Disease. Siiberbauer. iCa-I Plasma-6-Thromboglobulin. 482 Angiographically Determined Coronary Artery Disease. Morrison. John A. Studies of Biood Pressure in tgq HbAfC and Prostacyclin Formation in Juvenile and Maturity Onset Diabetics. Kath0r. MOgq On the Mechanism of the 93 School Children and Their Parents In an Integrated Surtxrrben School District. Taggart. Hugh McA. Risk Factors In Stroke. Antilfpolytic Action of Prosteglendin E2. 494 Hutt. Volker HVL• and LDL-Cho/esterof in 485 Numano, Fujio Plasma Thromboxane eZ Patients with Hyperlipidemis Type 119. !V and V Treated Concentration /n Healthy Japanese and in Patients with Afherosclerosis. 95 with Dillerertt tipid Lowering Drugs. McContithy, Walter J. Lipid ar+d Apollpoprotein 486 Butkus. Antanes Platelet Aggregation and Levels In Subjects with Thromboxane Produc!ion In Patients with Diabetes. Peripheral Arterial Disease (PAD).

V. r 496 Bahler. Robert C. Ouatitative and Ouantitative 505 Brunner. Daniel The Influence of Moderate i ~ 97 Alterations in the Electro- phoretic Patterns of Plasma Lipoprotefns in Patients with CAD. Saxena. Ram Pratap Raised Lipoproteins in 06 alldius. Goran Lsistire Time Sport Activities I on High Density Lipoprotein Cholesterol in Subjects 35- 74 Years. Linoleic (fB:2) and ' 498 Stress Situation. Rossouw. Jaclues E. A South African Coronary Arachidonic (20:4) Acid in HOL2, HDL3 and Whote , Serum ot Uremic Patients Risk Factor Study. . 507 Kirsteln, Peter HDL-Cholesterol in Periph- h~ 499 Jan Cigarette Smoking and Augustin . Lipoprotein Metabolism. 508 Kirstein. Peter eral Vascular Disease. HDL and HOL Cholesterol 500 Hyperlipidemta and Athero- Singh R B p 3 , . . sclerotic Heart Disease in Patients of Pulmonary 509 Mural. Atsushi : in Healthy Mon. Significance of High- Tuberculosis. Density and Low-Density Lipoprotein Cholesterolln the ~ Patho enesis of C al b HDL: NECsA'T'I10E RISK FACTOR - Ii! 510 Barborlak. Joseph J. g ere r Infarction. Coronary Artery Occlusion. ~ ~ HDL Cholesterol and Alcohol Camellia Room Chairpersons Intake. Kac3 Berg Drago Reichl thor Title t A Fi rs u $Of- 502 Aro. Antti V. Fsmity Study of HDL- Cholesterol In Coronary Heart Disease. Ishikawa, Toshitsugu Apotipoprotein A-i, A-l1 and IE High Density Lipoprotein- Cholesterol in Diabetic ~ Patients. ~ 503 Knuuss. Ronald M. Relation of Serum High I t7ensity Lipoproteins (HOL) ~ to Gonadotropin and Estro- gen Levels In Post- Menopausal Estrogen Users end Monusers. I ; W4 Yasugl, Tadao Changes of HDL2 end HOL3 in increase of Concentrations f Induced Alcohol and Penteerythrltol Tetra- nicotinate (PERICfT). ,

_.-....---•.- 7 I FLOOR P9j%N OF SHAMROCK SYMPOSIUM INFORMATION REGISTRATION AND INCIUIRIES: Registration will be held in the Grand Ballroom Foyer at the following times: Monday. November 5th 12:00 noon - g:00 p.m. Tuesday. November Sth - e:0S1 a.m. - 3:30 p.m. Wednesday. November 7th 8:00 a.m. - 5:00 p.m. Thursday. November 8th 8:po a.m. - 12:00 noon A multi-lingual staff will be available to assist participants. MAP OF ROOM LOCATIONS: On page 91 of the program is a floor-plan of the Shamrock Hilton to assist you in locating each session. IDENTIFICATION BADGES: ~ Name badges will be issued to all participants. These badges should be worn throughout the Symposium as admittance to the Sessions will be by badge only. Accompanying guests will receive a blue badge. SCIENTIFIC PROGRAM: The Plenary Sessions wiil all be held in the Grand Ballroom each morning beginning at 8:30 a.m. There are8cortcurrent Workslwps each day beginning at 1:30 p.m. and 13 concurrent Oral Presentation Sessions each day beginning at 4:00 p.m. Please check the Program for room assignments for the Workshops and Oral Presentation Sessions. BOOK OF ABSTRACTS: Each participant wiit receive a Book of Abstracts at Registration. Additional zopieswitf-be-avaiiabie 1or sate. i i I C

SPEAKERS: - It is vitally Important that speakers report at least 15 minutes prior to their Session with their slides. There will be a staff member available to assist the Chairpersons at each Session and a staff member to handle the slides. Please pick your slides up at the end of the Session. Unclaimed slides will be taken to the hospitality suite. REFRESHMEh9TS: Thhere wiic be a coffee and tea break each morning during the Plenary Session. Coffee and tea will be served all day in the Hospitality Suite (located in the Crystal Room). LUNCHEONS: There will be no ofticiai luncheon for the Symposium. Luncheon break will be from 12:00 to 1:30 eachday: There are several dining - faciiities in the Shamrosk Hilton. Please.onsutt the floor-plan in the program for their iotation. [1RESS: Casual dress for Rodeo and Ba--B-0ue. Coat and tie would be appropriste for the Banquet. TOURS: Paid tickets for accompanying guests will be in the registration packet. Unpaid reservations can be paid forduring registration on Monday and Tuesday Banquet tickets can be purchased until noon Wednesday during registration in the Grand Ballroom Foyer. MESSAGES: A message board will be tocated In the Hospitality Suite. Ptease consult the Message Eoard regularly. Any message not-picked up by 6:3(o P.M. each evening will be given to the front desk. If you are not staying at the Sitamrot~t Hilton please notify staff in the hbesnitaiihr Suite so tf•at we can get a message to you. BANK: Arrangements have been made with the Fannin Bank. located directly across from the Shamrock Hilton on Main Street, to assist you-with banking matters. The Fannin Bank is open from 9:00 a.m. until 2:00 p.ot. each day: PHOTOCOPYING: A photocopier will be available for use by the participants in the Hospitality Suite. PRESS DESK: t:nquiries regarding publicity and press mattels should be made at the Press Desk, which is located in the Hospitality Suite. MEDICAL SERVtCE: Particiaants with medical enquiries should speak with Mrs. Lee Miller. R.N. or Ms. Linda Crabtree. R.N. in the Hospitality-Suite. 1.OST AND FOUND: Participants should report any loss to staff In the Hospitality Suite. - CERTIFICATES OF ATTEQdDANCE: Certisicates of attendance may be obtained in the Hospitality Suite. MANUSCRIPTS: All invited speakers will have a notice In their registration packets indicating whether or not they will need to meet with Ms. Barbara Allen regarding their manuscript. Ms. Allen will be in the Grand Ballroom Foyer with a representative from 5pringer-Veriag to discuss only those manuscripts that need corrections.

SOCIAL PROGRAM INFORMATION: The social program blends a part of the cosmopotitan touch of the world's foremost oil city with a Texas style Bar-B-Oue and Rodeo. The following sciledule of dutriiies is planned: . Tuesday. November 6th 7a10 p.m, iTodeo and Bar-B-Oue in Simonton. Texas as our guests Buses will depart outside the main entrance, under the canopy for the trip to Simonton. When ycu arrive a fantastic Bar-B-0ue dinner will be wailing, with live countrv music to enjoy with your dinner, and then the thrills of an authentic Texas rodeo. Wednesday. November 7th 730 p.m. A Colloquium on "?he Declining Death Aate from Cardiovascular Disease" in the Grand Ballroom (A cash bar wiii-be open frcm 5:30- p.m. until 7:30 and from 10:00 p.m. until 10:30 p.m.) Thursday. November 8t h 7A0 p.m. A Banquet will be held in the Grand Ballroom (A cash bar will be open from 7:00 p.m. until 8:00 p.m. Dinner will be served at 8:00 p.m. Tickets for the Banquet can be purchased in the registration area until 12:00 noon on Wednesday.) In your registration packet las-"Guldatol)iningOut In Houston" and a brochure entittesE "Hare's Houston Day andF Night". The staff in the Hospitality Sui4s will t,e available to advise you and assist you should you need help or require transportation while visiting us. ii LADIES PROGRAM: Tuesday, November 6th 11:30 a.m. - 4:00 p.m. ~ We would like all of our guests to foin us for luncheon at the Petroleum Club. Bugeswiltdepart outside the mainentrance under - the canopy at 1 f:30 a.m. to take you to luncheon. You will be treated to an lndepth view of Houston after the luncheon which will enable you to-seeihe-historical beginnings of Houston, the Civic Center and the Alley Theatre. There will be a leisurely drive through River Oaks, a beautiful residential area of Houston, where many of Houston's distinguished residents live in palatial homes situated on beautifully landscaped grounds. The tour will inciude the Medical Center and Hermann Park with its award winning Miller Memorial Theatre and the Fragrant Gardens - planned especially for the blind. Wednesday. November 7th 10:30 a.m. - 3:00 p.m. The morning begins with a tour of the Museum of Fine Arts which has grown into a repository for the finest examples of world art. Each yea'-aver a quarter of a million people visit the Museum. Guests will th$n proceed for luncheon at La Hacienda De Los Morales where the cuisine is continental. The afternoon will be spent at the Astrodome, classified as the eighth wonder of the world. This truly unique structure maintains a constant 72° temperature the year round and can be converted within a few hours to accommodate most any type of sports event - from - basebail to polo to motorcycle races. Thursday. November 7th 10.00 a.m. - 4:00 p.m. Guests will visit the Galieria Shopping Center, which contains more than 200 boutique and speciaNy shops surrounding a year- round ice skating rink. There are also many fine restaurants, and the Galleria is also home to major department stores such as Neiman Marcus. Lord and Taylor, and Saks Fifth P.venue. For luncheon. a buffet will be served at the Galleria Roof, 28 ftoors up, with a panoramic view of the Houston skyline. There will be a fashion show by Isabell Gerhart, at noon, showing the newest in the fashion world. After luncheon we thought you would enjoy touring Bayou Bend, former home of Miss Ima Hogg, daughterof a governor of Texas. This magnificent house is now a part of the Museum of Fine Arts and houses an extensive collection of 17th, 18th and early 19th century antiques and many fine works of art. The grounds surrounding the estate are truly lovely. Friday. November 9th This day Is free for you to do as you like. f

n ANiNOUNCEMEidTS: - - American Heart Association, Mondey. November Sth Nutrition Committee Meeting, 9:AEX a.m. - 6:00 p.m.. Belvedere A< Exec~..itiva Committee. Tuesday. November 6th American Weart Association. Nutrition Committee Meeting. 9:00 a.m. -12:00 noon. Belvedere A. WednescJay, November 7th Luncheon Meeting of the Council on Atherosclerosis of the Inter- national Society and Federation of Cardiology. 'i 2:00 noon - 1:30 p.m.. Walnut Room. Thursday, November 8tA Luncheon Meeting of the Executive Committee and Council of the Inter- national Atherosclerosis Society, 12:00 noon -1 ;30 p.m.,Venetian Room. National Research and Demonstra- tion Center. Baylor College of Medicine. Outreach Program. Continental Breakfast. 7:00 - 8:0ff a.m.. Castilian Room A/B/C. General Organizatiefnal Meeting of the International Society of Atherosclerosis chaired by Gerhard Schetter. M.D., President 8:00 - 8:30 a.m., Grand Ballroom. Luncheon Meeting of the Steering Committee, U.S. Italian peiegation, 12:QO noon - 1:30p.m., Board Room. Luncheon AAeeting_of the European Atherosclerosis Society. 12:Ot1 noon - t:34 p.m., Venetian Room. Fridsy, November 9th Jourrlal of Upid Research. Editorial Board Meeting 8:30 - 8:00 p.m., Board Room. U.S. Italian Symposium on Prostaglandins & Cardiovascular Disease National Meart Lung aftd Blood lnstfitute. 9A0 a.m. - 5:00 p.m., Castilian Room AIB/C. I Notes