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I11teati®nai , Symposium ® Atherosclr®sis + 1 ; ` November 6-9,1979 Houston, Texas 1" 1 i , i ~ Program under the auspices of the Internationat Atheroscterosis Society Honorary Sponsors Mrs. Mary Lasker Princesse Lilian Co-Sponsoring Institutions 9aytor College of Medirine The Methodist Hospital

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t3e9c Frker~ Message from the Chairman, V Infernational Symposium on Atherosclerosis TtysOrganittingCCmmittee otttte V 1nlemetic+mfSymposarmanak~erosde.osis Thg Meihodist NOSprtat end 6sytorCoqege o! Medicine }oin me {n welcoming you to "0uston. TRis6yntPos+uin is suppmled by meny indivkdut:tsend orger+izattons. The Mgthodist Hospital erd t3aybx College of Medicine have made it Poggibte to hold 'Ghe Meeiing +n Houston. Or William Holmes directed the fund raising aotivitie6 nutside of Texas. The CAUntal On Athero9oterosis ot trte American Heart Aasoc+ation. the Texas ANitttte and the Houston Chapter o1 the American HeeR AS3oCi8twn ttre Co-Spord0*V this meaLng. We are espaciany honored to hev0 as out HottorElry Co-SPO1t80ts Ct the $ymposyunt. Mrs. Mery Lasknr Irom h1ewY0rlt and Print:eSSOLiliBn ot 9elgium.whp ere t-o o1 the wortde +nomd-stinguished 8upportere ol8iomsdtcel Research. They Rave troth bsen especially intereste0 in progrmns tortne treaanent and prevention of t8rdtovlascuter drseese. tl is nsost eqropr:atethat Qe0 ol7ening SesSku n otihe Fhnntonsymposium steoutd be devoted to tqdoring Qottor Michael E. Det3sksy's eontritrutwna to the surgical il08tneent of gtherOgGlgrwis. The Symposium t><mg8 together a rerr9ty ot Owiplmes. tvom cardWvascutar surgsons to se+entists intereste0 in dret. platelets. Pr0518gtttndms. the rffoleaul9r UuitM of the arterial wetl, and the pethoganesisot 81herOgClerdgig in Iipid and 4poprotein met8U01i9T. A special coilOq W Wti to be held on wedneYdAy Brening. Nnvemtfer 7th under the 9uBPwAs of the PrinCegSe Lilian Cerdsoyogy Foundatron. will focus onthe quest+on ot the OeWining Deatfi Rate from CoronBry Artery Oi,sease Nre atticipetetnat the presentation and drstussion of new disCOV61t890rM new ecAsesemente witl excite imestigetonto erenewed dedicatwn towarda the eorsquesi ot eerd,ovaseular disease. ThBSoGiatprogr8rn tstgm2s the OosmopW iten toveh of the weMd'e fexemose oil eity wHh some Te>r&s atyleg8r• 3-OrJe end Rodeoaatiritres.On behaf?ot tny staff and the prgenriing Cormnittee. wo nope that you spend an Interesting and enjoya0le week In Houston. Yours sirucerety. ~~ K. 4;EG:- 1)

, INTERNATIONAL PROGRAM COMtwITTEE: Jean-Louis Beaumont Henry Buchwald - Lars A. Carlson William E. Connor Alan J. Day Fredric H. Epstein Yuichiro Goto Antonio M. Gotto, Jr. M. Daria Haust William L. Holmes Anatoli N. Ktimov David Kritchevsky K. T. Lee Kare R. Norum Michael F. Oliver Rodolfo Paoletti Gotthard Schettler Gunther Sclllierf Yechezkiel Stein Daniel Steinberg Jack P. Strong AD HOC ADVISORY COMMITTEE: Gustav V. R. Born H. Bryan Brewer, Jr. Richard J. Havel Robert I. Levy Robert W. Mahley Russell Ross - Richard W. St. Clair David C. Sabision, Jr. Angelo M. Scanu Colin J. Schwartz Harvey Wolinsky 4 FUND RAISING COMMITTEE: CHAIRMAH~- William L. Holmes Lars A. Cartson Yuichiro Goto W. Dsria Haust David Kritchevsky Henry C. McGill Paul J. Nestel- Michael F. Oliver Rodolfo Paoletti Gotthard Schettler Yechezkie( Stein Daniel Steinberg - Robert W. Wissler TEXAS ORGANIZING CO@YINtITTEE: CHAIRMAN: Louis C. Smith Arthur C. t3eall Gerald S. Berenson Mark L. Entman Joseph L. Goldstein Dudley Hafner Sam Inman Henry C. McGill Richard R. Miller Jerry R. Mitchei( Joel D. Morrisett Josef R. Patsch Henry L. Pownall James T. Sparrow Jack t_. Titus LOCAL RECEPTION COi'd1MITTEE: Mrs. Ted Bowen Mrs. AntonioiVl. Gotto, Jr. Mrs. Randolph Schaffer

11 .. aNSMUT oNs AND CORPOAATIONs: Baylor College of Medicine The Methodist Hospital The International AtIerosclerosis Society Council on Arteriosclerosis of the American Heart Association The American Heart Association The American Heart Association; Texas Affiliate The American-Heart Association; Houston- Chapter Abbott Laboratories Ayerst Best Foods Burroughs Wellcome Company Ciba Geigy Corporation Dow Chemical L.ompany. USA Hoffman-La Roche. Inc. hmecican Cyanamid Company Eli Lilly and Company McNeil Laboratories- Mead Johnson Pharmaceutical Division Merck Sharp & Dohme Research Laboratories Norwich Eaton Miles Laboratories, Inc. Ortho Pheirmaceutical Corporation - The Proctor and Gamble Company William H. Rorer, Inc. Sandoz, Inc. - Schering -Corporation G. O. Searle and Company Smith, :Clirte-and-Erench Laboratories Standard Brands, Inc. Sun Company Syntex Research The Upjohn Company Wyeth Laboratories,-Inc. ACKNO1AfLEDGEMEN'PS• We gratefully acknowledge these individuals, institu- tions, organi2ations and companies whose generosity and support have made this meeting possible: THE ORGANIZING COMMI[TTEE. CHAIRMAN Antonlo M. Gotto, Jr. CO-CHAIRMAN Yuichiro Goto GENERAL SECRETARY Louis C. Smith

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11 SCIENTIFIC hROGRAM AT A GLANCE Belvedere B Room LC LENARY SESSION: Grand 9atirosm - Tuesday :30 a.nfl. - 12:00 noon Cardiovascutar Surgery AT - I Castiiian,A/B/C Room Cardiology - Myocardial tschemia -1 Cameliia Room Hemodynamics - i USNngs !ol iyorASNpP Proglanrs do nof neeesaarfy l6//gC/ Olde/ ol P'"emdrfbng. WORKSHOPS: 1:30 - 4:00 p.m. SCIENTIFIC PROGRAM AT A GLANCE Embassy Room Coronary Bypass Surgery Wednesday ,t;',rQve Room Epidemiology of Atherosclerotic Lesio ". PLENARY SESSION: 8:30 a nt 0 i Grand Bailroom . . 0 noon Marco Polo Room Drug Treatment of Hyperlipidemia Dietary Prevention of Coronar H Azalea Room The Arterial Wall -1 y eart Disease Bluebonnet Room Lipid. Apoprotein and Lipoprotein Origin and Synthesis - WORKSHOPS: 1:30 - 4:00 p m Camellia Room Lipoprotein Structure Azalea Room . . Hype+lipidemia: Pnsvatence and Inh eritance Embassy Room Risk Factors In Children ORAL PRESSPe'YIC4tOP3S: 4:00 - i6:30 p.m. Marco Polo Room Diet Treatment of Ath Embassy Room Animal Models of Atherosclerosis - I Bluebonnet Room Grove-Room - eroscferosis immunofogy A Marco Polo Room Epidemiology - I _ Cameiiia R nimal Models Grove Room Drug Effects in Animals - I oom EnzY+nes of LP Metabolism Azaie,e Room Smooth Muscle Cell - I BtueBionnet Room The Arterial Wail - I ORAL Q:00 . Normandy A Room Non-Dietary. Non-Pharmacological PRESENTATIONS: • 6.3b p.m. Therapy of Hyperlipoproteinemia - I Azatea Room Smooth Muscle Cell - it i/enatian Room Hormone Effects of Hyper- li Bluebonnet Room The Arterial YVap poproteinent€a - I Venetian Room - il Diet-11 Nile Room Regulation of Cellular Cholesterol N ormandy A Roo Metabolism - ! m Metabolic Origin •of Hyper- Belvedere A Room LDL Structure - t N ile Room lipidemia -11 Normandy i} Room HCIt_ Strucfiffa . I s -•- - - LOL Metabolism - il

v Normaady S Room Belvedere B Room Casuiiian A/S/C Room Embawj Room Marco Polo Room Grove Room Lipoprotein Lipase - 11 Thrombosis and Immune Complexes - I Risk Factor Modification Animal Models of Atheroscterosis -11 Epidemiology - tl Drug Effects anii Therapy In Man - II Lis&W ror W.arknnop Frogrmns do nor neoessaNty relfecl ord6r ol praagnrBfiOn SCIENTIFIC PROGRAM AT A GLANCE 'Thursday QLENARY SESSION: 8:30 a.m. - 92:00 noon Grand Ballroom The Vessel Wall in Atherosclerosis WORKSHOPS: Marco Polo Room Azalea Room Embassy Room Grove Room Btuebonnet Room Camellia Room 1:30 - 4:00 p.m. Non-Dietary. Non Pharmalogical Treatment of Hypertipidemia HDL: Negative Risk Factor for CHD Ci6ical Trials The Arterial Wall - 11 Vessel Wail-Piatelet Interaction- Catabolism of Lipids, Apolipo- proteins and Lipoproteins ORAL PPIESENYATIOMS: Embassy Room Marco Polo Room Grove Room Azalea Room 4:00 - 6:30 p.m. Animal Models of Atherosclerosis - III Epidemiotogy - III Drug Effects and Therapy In Man - III Smooth Muscle Cell - I II t3tuebonnet Room Venetian Room Normandy Room Nile Room Belvedere Room Normandy g Room, Belvedere B Room - CastiNian A/B/C Room Cametlia Room rhe Arterial Wall - iu Oief - III . "Genetics of Hyperlipopro- teinemia - I I I LOL Structure - III HDL Itdetaboiism - /lt VLDL Metabolism Platelets Regression HDL - Negative Risk Facto r - 111 Lrsrnrtgs rar WorksAop FrograM d,,,w,, ~ssray r~lieer orofer or pigsenlerfon. SCIENTfFIC"19ROGRAAR AT A GLANCE Friday PLENARY SESSION: 8:90 a.tn, - Tg,0p noon Grand Ballroom Plasma Lipids, i-i~protetns Atheroscierosfs and WORKSHOPS: 61uebonnet Room Marco Polo Room Embassy Room Grove Room Azalea Room Cameiiia Room 1:3d1- 4:00 p.tro. Mutants Affecting .Lippprotein and Apoproteins HYpertension Regression The inter-Refationship Between t.ipid and Prostagiandin Metabolism Cellular Metabolism ot Lipoproteins Apoprotein Quantification

v- ORAL pRESEPlTATf ONS: Embassy Room Marco Poto Room Grove Room Azalea Room Btuetsormet Room Card Room Normandy A Room Nile Room Belvedere A Room Normandy B Room Beivedere B Room Castilian Room Qartselka Room 4:00 - 6:30 p.m. Animal Models of Atheroscierosis-IV Risk Factors in Children - IV Drug Effects and Therapy in Man - iV Endothefial Cell - IV The Arterial Wall - IY Exercise and Diet - IV Lipoprotein Methodology - tV LDL Metabolism - IV Apoprotein Structure - IV _ Lipoprotein Lipase - IV Prostaglandins - IV Risk Factor.Synergism HDL: Negative Risk Factor - IV Lrs/irrg5 for Workshop ProgrBms do not neaeseerily rotlsa' order of presentatfon. . Irm"OGRAM INIi-" MJ°i1TIO® UES®AY November 6th, 1979 k

PLENARY SESSION: CARDIOVASCULAR SURGERY 8:30 a.en. - 12:00 p.rst. - Grand Ballroom Chairpersons E. Stanley Crawford - David C. Sabiston. Jr. Participants Michael E. DeBakey Patterns of Atheroselerosis Harris S. Shumaker. Jr. Mechanism of Progress. Page from the History of Cardiovascular Surgery Charles Oubost Surgery of the Heart and Great Vessels David C. Sabiston. Jr. Surgery for Coronary Artery Disease CONCUR RENT WORKSHOPS: 1:30 - 4:00 p.m. CORONARY BYPASS SURGERY Embassy Room EPIDEMIOLOGY OF ATHEROSCLEROTIC 71 LESIONS- ~ Grove Room Chairpersons Yuichiro Goto Jack P. Strong tntroduction: Workshop on Epidemiofogy ot~ Atheroscierotic LesFons Participants- MaNo t3arcia-Palmeri ~~ l1w William B. Kannel Postmortem vs. Clinical Risk Factor Correlations. The Framingham Study. Lars A. Solberg Risk Factors for Coronary and Cerebrovascular-Atheroscferosis in the Oslo Study. Grant Stemmerman Atherosclerosis and Its Risk Factors Among the Japanese. Nils Sternby Atherosclerosis. Smoking end Other Risk €actors.- DRIDG TREATMENT OF HYPERLIPIDEMIA Marco Polo Room Chairpersons Michaei i=. DeBakey J. Willis Hurst Chairpersons David Kritchevsky Rodolfo Paoletti Participants Participants - John F. Goodwin My Current Vfeias Regarding ' Donald B. Hunninghake Drug Treatment of Type li Hyperlipo- Coronary Bypass Surgery proteinemia. Effects on Plasma Lipid and Lipoprotein Levels- Gerald M. Lawrie- Results of-Cof.onary Bypass: A-L-ong= John P. Kane Synergism fn Drug Treatment of Term Perspective Amilial Hyperct,ofesterolemia Henry D. Mcintosh Current Views Regarding Coronary Anatoll-N.- Klimov- Effect of Plasma Lipoextraction and Bypass Surgery - fnfustr'oa of Heteroiogous slDi orrthr Richard Pk. Milidr Comparison of Medical and Surgical Development of Experimental Mortatify in a Hfgh Risk Subject of ; Atherosclefosis In Rabbits Coronary Patients with Extreme David Kritchevsky Nutritional Factors in AtheroscJerosis Degrees of Exercise - ia l h Anders G Ol N em sc Induced . sson ew Drug Treatment in Hyperlipidemia David C. Sabiston. Jr. Cesare R. Sirtorl Apoprotein Changes Following Harris B. Shumaker, Jr. I TrAaln.o»rQ ...l0s. -- -