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BRITISH-AMERI CAN TOBACCO COMPANY lIMITED IR&DC RESEARCH PROGRAMME & RESOURCE ALLOCATION 1984-1986 :(a) GROUP R&D PROGRAMME ,~,,,-~:~ ' :i:(b) PRODUCT TECHNOLOGY AND TECHNICAL SERVICES :;i,,:!: ,~.-. :>:(SUMMARY ONLY) ," , :. ,;:i'.:i,/ D I STR i BUTi ON: • 6. A.M. Heath/j.A.B. Kellagher • t . , 1" E.A.A. Bruell • R.J. Pritchard !i~. 4. ~':D.G. Heywood/P.A. Richardson ~- L.C.F. Blackman 8. , N. Davis - ::9 .... J.P. Sikkel 10. M. Norsworthy 11. 12. 13. 14. 15.- R.A. Sanford E.E. Kohnhorst P.J. Dunn E. Rittershaus F. Seehofer 16. C.J.P. de Siqueira 17. P.M. Denton 18. R.G. Nicholls 19. A.L. Heard 20. C.I. Ayres 21. M.J. Hardwick 22. R. Binns 23. P.H. Gannaway RESTRICTED November 1983. MAY BE OPENED AND SEEN ONLY BY THE ADDRESSEE AND PERSONS AUTHORISED BY THE ADDRESSEE

CONTENTS FOREWORD SUMMARY OF RESOURCES ALLOCATED TO THE GROUP R&D PROGRAMME AND TO PRODUCT TECHNOLOGY AND TECHNICAL SERVICES TOTAL GR&DC STAFF ALLOCATION (1984) ORGANISATION • GR&DC PROFESSIONAL STAFF PAGE i ii iii iv v&vi GROUP R&D PROGRAMME 01 Biological Research 02 Smoke Research 03 Smoker Behaviour 04 Flavour Research 05 Process Research: - Physical Properties of Tobacco - Chemistry of Processing & Expansion Studies - Novel Cigarette Technology 06 Analysis and Test Method Development 1 11 23 35 45 53 59 67 Specialist Resources Appendix I PRODUCT TECHNOLOGY & TECHNICAL SERVICES Financial Sugary Appendix II CA :D F.w CA

FOREWORD The GR&DC get proposals were the BATCO Board in November, !98: kis docume a year ago, .:with the major differences that_project organograms are shown against ~ork area and the bar-charts are aced by descriptions of tasks and timescales. Programme has been formul in the light of discussions the Research Conference in August, 1983. iMajor agreed changes to current1983-85 Work Programme are:;!:~!,i~i~ii.~i:~:~,i~:,~it:~i?~r,;.~:c,!~,,/,:,.:'~ Iter~Nitrosamines;Sidestreamand Combustion research are In a new Work Area 02, Smoke Research .... c~,,. g;smok'e"xero£Gi:;P~{;iogical"andPharmacoibgical ;/!: are now a new Work Area 03, Smoker Behaviour. md Biotechnology Expansion, and Novel Cigarette Technology research are now )ed within Work Area 05, Process Research ...... Control and Physical Test Method Development is removed tom the,Work Programme. Any future activities on physical test methods will probably be incorporated into Work Area 06, Analysis and Test Method Development. aCtivitie'sare~piit between Product Technology ,(application) and Group R&D Programme (research). Psychology • esearch is included in Work Area 02, Smoke Research, and in Area 03, Smoker Behaviour.- , , .... i~!,~,~ii~,,::/~!,~I~ ~arate resources areailocated to Future Technologies, Special Projects, Smoking Issues and International and Specialist Committees. ~se activities are summarised in Appendix I. ~ ~:~./:C~! /~i!~ ::.,-.,~::;~: balance of the GR&DC Work Programme i.e. that which is not funded by Group companies on an 'allocation - formula' basis, is shown in in the sister document entitled "Product Technology and Technical ~::~i Services - Programme and Resource Allocation 1984". This was approved ~;~.,~In content by the~i~n~J~be~and a summary of the budget -:- is given in Appendix FI. '- November, 1983 1. Ob

SUMMARY OF RESOURCES ALLOCATED TO THE GROUP R&D PROGRAMME AND TO PRODUCT TECHNOLOGY AND TECHNICAL SERVICES Group R&D Programme Biological Research Smoke Research Smoker Behaviour Flavour Research Process Research: Physical Properties of Tobacco Chemistry of Processing & Expansion Studies Novel Cigarette Technology Analysis & Test Method Development Specialist Resources Totals Product Technology & Technical Services+ Total++ Direct Effort* Graduate Assistant Years Years 3 14 6 12 7 9 8 13 S 5 5 3 I 5 2 6 4 41 67 '12 12 • 53 79y' Total Revenue** ( 000) 1984 1985 1986 869 11224 1152 1112 616 731 433 407 539 76~0 7083 7200 7200 I.:Z-~ 1 2151 2100 2100 9234 9300 9300 I All revenue figures are in 1984 terms. ~'~ NOTES: *These figures show the number of man-years specifically allocated to the Work Programmes. Seconded Personnel, Administration and Technical Support Staff are excluded. **In addition to the cost of Direct Effort, the Total Revenue includes both specific costs (e.g. Contracts, Leaf, Travel) and an allocation of Administration, Site Services, Depreciation, etc. +Details in sister document. ++Staff numbers for the Group R&D Programme do not necessarily correspond with the names given on pages v and vi - because in some cases fractional staff effort has been allocated from or to Product Technology & Technical Services. © t983 British American Tobacco Co. Ltd. This rnus¢ not be copied or sllnwn to un2uthofised persons. Ul h.w ¢=

• Technical Supporl ::.Management Support Hon-Technical Supportc (Allocated) chnology & Technical Services Effort 71 . 208 ~AND TOTAL NOTES: 1. ; i-.....~ .. 279 Man Years -.. . . Technical Support provided by Ceni~ral Analytical Service, Statistics & Computing and Sample Manufacture. Non-Technical Support from Accounts, Administration, Engineering/ Workshops, Catering, Security, Stores and Library/Information.

"4." ~Patents ',=~ ..... ~,: Planning - " " K.J.H. P.H. Gannaway ,6. ~nith RESEARC"I R.R. Baker .~:~ BEHAV TOUR Read " • :"'T '-'*'~;~f~ - ...."" ':~'~ RESEARCH R.A. Crei ]in Future Technologtes :K.D. Kilburn Spect al Projects H,G, Horsewel 1 - -. -:::~;. -. ..... -Physics R.G. llook -Chemistry -Expansion R.W. Hedge ~(~:?~-~ ,. . -tiovel Cigarette Technolog) O.A. Luke "Secondary --,Automation R.G. Bryant SCIENTIFIC SUPPORT .. R. Binns , --, , • r . o DEVE I.OPHEIIT .II.F.D. D~mond I Library and --Information F. Marsh __Computing D.B. Mullen r, - SI[E AD~INISTRAT ION ~,J. Hardwick Admi ni st rati on JEngineering -'-R. Smurthwa!te iPersonnel --M.S.R. Douglas sample " " " . . .. --Manufacture J.F.K. McCreadie Statistics "--E.B. Wilkes Sensory --Testing B.C. Harding Flavour Manufacture PRODUCT I TECHNOLOGY J & TECHN ICA[J SERV ICES 'J Product . --Development T, Hirji ".: Psychology ' -'-R,P, Ferris Sidestreaml --Special ,~, Projects ~ W.D.E. Irwi

GR&DC PROFESSIONAL STAFF <- , , - : > SPECIALIST RESOURCES '.:. Future Technologies:-- Dr. K.D. Kilburn .'~ .:.,::-.:!~ .. ::..~_~..~--.... /.. .... Special Projects: :,.~,.~-~,-~. H.G. Horsewell "o A.G. Barnes* Dr. P.C. Bevan Dr. G.A. Few "Dr. J.D. Green T.G. Mitchell Dr. P.S. Stewart Dr. T.W. Tolman A.N. Other .,,,; :,~. ... - .. PRODUCT"TECHNOLOGY MANAGER: ~!~:-...~<t~:~:~,i~ A.L. Heard Manager: .,4-~-:~:~,Dr. T. Hirji • ~:~"'~°,-~,-~,.~-~."~-- '~ ~':;~- E. Alty • ~:~,' .. "- -!~,'-. :;': ;-,,: ~ .... ' ..... " N. Bruce-Miller "~~:~#:y~L~ " ":: " D.E. Creighton ..... - " ur. C.C. Greig • Dr. C.R. Jenkins A.G. Stephenson .< Psychology** Manager: R.P. Ferris Dr. L. Miller Dr. L. Sumiga Sidestream Manager: W.D.E. Irwin SPECIALIST RESOURCES (see also above) International and Specialist- Committees Smoking issues Patents Dr. S.R. Evelyn Dr. R.E. Thornton K.J.H. MacL~an Planning P.H. Gannaway .,% .._.~ .:",.v ~ ~" ........ ,on return from secondment overseas. ,,~. **A significant proportion of staff time will be allocated to_research, in close , . ~ "~'~'~:: r :" association with Smoke Research (Work Area 02) and Smoker Behaviour (Work Area"(~ •, ~:~.: .... ...-. ~. :.. i ':!, ~,~.~ ... _~, ~,~

6R&DC PROFESSIONAL STAFF (CONTD.) . . -..>,:,>.~-..~ ..... . ...... . . . . ..... ,~e.~,aa >- ,: ~,-,~ "~"' : SUPPORT PROCESS RESEARCH ~.o,,ee~,-~....~5.~,,:.,- SCIENTIFIC RESEARCH MANAGER: Dr. M.J. Hardwick .~-e RESEARCH MANAGER: Dr. R. Binns ANALYSIS & TEST METHOD DEVELOPMENT .=, . . -.- Group Leader: ... H.F.D. D~mond .... :' :"~ C.L. Proctor ':-#' , .... '", W.J. Roles Statistics -',- E.B. Wilkes ,Computin9 .i: D.B. Mullen .- ,. ---~- B.M. Watts " Hhrarv & "..~ " ~'- :' Information . Dr. F. Marsh • .; ° Flavour Manufacture :- J.F.K. McCreadie • .. .. " .._ • °-'• i

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i WORK AREA 01 BIOLOGICAL RESEARCH GROUP LEADER: G. SMITH f 80% I 01 PARAMETERS AFFECTING THE BIOLOGICAL ACT IV ITY OF SMOKE (PROJECT RIO) 60% [Ol(a) |Cigarette --|composition |and [construction .15% lOt(b) _ Activity of smoke components -02 5% lot(c) ) --|Smo k i n g EPattern I " 15% I DEVELOPMENTi OF SHORT TERM TESTS 10% TOTAL STAFF: 3 Graduates 14 Assistants EXTERNAL CONTRACTS: £91,000 (1984) FO2(a) IMutageni city -lof whole smoke Land vapour phase 5% 02(b) Enzyme induction model related to cancer ' I 5% I 04 CONSULTANTSi 03 HUMAN i STUDIES FO3(a) "I -|Smoking ano Lbodyweight 103(b) } --I Lung Ipermeabi I i ty o3(c) Development -- of athero- [sclerosis _[04 ( a ) ] IMutageni city [Prof. B- Bridges [04(b) _ --IHistopathology [Mr. D. Walker cn ~b c~