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CURRICULUM VITAE Do~ingo M. Aviado, M.D. President, Atmospheric Health Sciences, Inc. 152 Parsonage Hill Road, P.O. Box 307 Short Hills, 8J 07078 (201) 564-9156 PERSONAL DATA Born August 28, 1924, Manila, Philippines. Resident of the United States since 1946. Married to Asuncion P. Guevara, August 15, 1953. Children: M. Cristina Aviado-Gentile, Carlos B. Aviado, Domingo O. Aviado, Maria A. Aviado. EDUCATION M.D., University of Pennsylvania March 1948 University of Pennsylvania School of Medicine 1946 - 1948 University of the Philippines 1940 - 1948 Ilocos Norte High School, Philippines 1936 - 1940 POSITIONS HELD SINCE 1977 President, Atmospheric Health Sciences, Inc. I980 - Senior Director, Biomedical Research, Allied Corporation 1977 - 1980 Adjunct Professor of Pharmacology, DMDNJ 1978 - 1982 Consultant/Member, EPA Clean Air Scientific Advisory Committee 1978 - 1982 Founder, Orphan Pharmaceuticals, Inc. 1984 Interim Editor, Journal of Clinical Pharmacology 1984 - 1985 Small Business Innovative Research (SBIR) awardee from the National Heart, Lung and Blood Institute 1983 - 1984 Editorial Board, La Riforma Medica 1986 - ACADEMIC POSITIONS HELD AT THE UNIVERSITY OF PENNSLVANIA, 1947 to 1980 Professor of Pharmacology Acting Chairman of Pharmacology Associate Professor of Pharmacology Assistant Professor of Pharmacology Associate in Pharmacology Instructor in Pharmacology Assistant Instructor in Pharmacology Member, Parasitology Graduate Group Carl F. Schmldt Honorary Lecturer 1965 - 1977 1969 - 1970 1960 - 1965 1953 - 1960 i950 - 1953 1949 - 1950 1947 - 1949 1967 - 1977 May 1980 GSO70 4 3

Curriculum Vitae, Doming~g~o'M. Aviado, M.D. ~ Page 2 CGNSDLTANTSHIPS OF ATMOSPHERIC HEALTH SCIENCES, INC. SINCE 1980 Mobil Corporation, Princeton, New Jersey JRB Associates, Arlington, Virginia American Petroleum Institute, Washington, D.C. Johnson & Johnson Baby Products, Raritan, New Jersey Whittaker/Toxigenics, Decatur, Illinois Hoechst-Roussel Pharmaceuticals, Somerville, New Jersey Eli Lilly Research Laboratories, Indianapolis, Indiana Schering-Plough Pharmaceuticals, Patterson~ New Jersey Liberty Mutual Insurance Co., East Grange, New Jersey Innotech and Innothera, Paris, France Lincoln Pharmaceuticals, Paris, France Hoechst A.G., Frankfurt, West Germany Chase Pharmaceuticals, Chevy Chase, Maryland MISCELLANEOUS POSITIONS PRIOR IO 1980 National Institute of Health Postdoctorate Research Fellow 1948 - 1950 Philadelphia General Hospital, Philadelphia, PA Assistant Attending Physicianin Cardiology 1955 - 1972 Albert Einstein Medical Center, Philadelphia PA Visiting Lecturer in Anesthesiology 1955 - 1975 . University of the East, Manila, Philippines Visiting Professor of Pharmacology 1959 - 1975 Women's Medical College, Philadelphia, PA Visiting Lecturer in Physiology ]961 - 1962 Poison Control Program of Philadelphia, Consultant 1964 - 1970 Rutgers University, Visiting Lecturer in Physiology 1956 - 1967 Philadelphia Medical Society, Member, Ad Hoc Committee on Air Pollution and Air Hygiene 1967 - 1969 Rational Clearinghouse for Smoking and Health, Member, AU Hoc Committee on Air Pollution and Air Hygiene i969 - 1970 Graduate Hospital, University of PennsyIvania~ Chairman of Medical Advisory Committee, Clinical Research Center 1969 - 1970 American Heart Association, Member, Ad Hoc Committee on Cigarette Smoking 1969 - 197D Council for Tobacco Research, Consultant 1972 - 1973 United States Pharmacopeia, Delegate to 1975 Convention, Member, Advisory Panel on Allergy, Immunology and Connective Tissue Disease 1976 - 1980 National Institute of Occupational Health, Review Consultant for Criteria Documents 1976 - 1978 National Academy of Science - Rational Research Council, D.S. Army Basic Scientific Research Committee 1976 - 1979 University of Rochester, Member, Parent's Council 1976 - 1979 National Institute of Drug Abuse, Participant on Review of Inhalant Abuse 1977 National Center for Toxicological Research, Member, Inhalation Toxicology Committee 1977 DREW, Consultant, General Counsel on Enforcement, Food and Drug Division 1977 66O7O4454

C Curriculum Vitae, Domlngo M. Aviado, M.D. ( Page 3 National Institutes of Health, Member, ~europharmacology Study Section Environmental Protection Agency, Member and Consultant, Clean Air Scientific Advisory Committee Montclair State College, Advisor, Toxicology Program Development Environmental Protection Agency, Participant, Workshop on Subchronic Toxicity Testing 1978 1978 - 1980 1979 - 1980 1979 - 1980 EDITORSHIP: Chemical Abstracts, Section Editor Circulation Research, Associate Editor Dorland's Illustrated Medical Dictionary, Editorial Consultant Stedman's Medical Dictionary, 23rd Edition, Editorial Consultant Archives Internationales de Pbarmacodynamie et de Tberapie, Member, Advisory Editorial Board Cardiology, Member, Editorial Board Soapel and Tongs, Journal of Medical Philately, Editor Drug Information aournal, Member, Editorial Board Journal of the Association of Philippine Practicing Physicians in America Journal of Cardiovascular Pharmacology, Member, Editorial Board Journa] of Environmental Pathology and Toxicology, Section Editor, Inhalation Toxicology and Pathology Journal of Clinical Pharmacology, Interim Editor 1952 - 1960 1958 - 1962 1963 - 196z 1972 - 1975 1965 - 1977 1967 - 1977 1971 - 1974 1974 - 1977 1976 - 197~. 1977 - 1984 1978 - 1984 1984 - 1985 HONORS: Alpha Omega Alpha Honorary Medical Society I946 Rockefeller Foundation, Travel Award 1961 Guggenheim Foundation, Fellow 1962 - 1963 First International Pharmacological Meeting, Stockholm, Sweden, recipient of the Linnaeus Medal 1961 Second International Pharmacological Meeting, Prague, Czechoslovakia, recipient of the Purkinje Medal 1968 Third International Pharmacological Meeting, SaD Paulo, Brazil, recipient of SEPHAR officer rwedal 1965 Philippine Medical Association, Chicago, recipient of Physician of the Year Award 1969 University of Pennsylvania Undergraduate Teaching Award 1971 University of Santo Tomas (Manila) Luls Guerrero Honorary Lecturer 1972 University of Pennsylvania, recipient of Lindback Award for Distinguished Teaching 1974 Philippine Presidential Trophy for Most Distinguished Filipino Abroad 1975 Association of Philippine Practicing Physicians in America, recipient of Apolinario Mabini Educational Award 1975 660704455

( Curriculum Vitae, Domingo M. Aviadn, M.D. Page 4 Sociedad Peruano de Farmacologia y Therapeutiea Experimental, Peru, Honorary Member 1976 Socleta Italiano di Angiologia, Honorary Member 1977 Embassy of the Philippines (U.S.), Delegate to the American Academy of Political and Social Science 1977 Carl F. Schmidt Honorary Lecturer, University of Pennsylvania 1980 French Pharmacological Society Honorary Lecturer 1982 University of Messina (Italy) Honorary Lecturer 1983 S0CIETY MEMBERSHIP Physiologlcal Society of Philadelphia (Ig48): Secretary (1954-1958); President (1959-1960), Councilor (1960-1961). American Society for Pharmacology and Experimental Therapeutics (1950): to-Chairman of Fall Meeting (1965); Member of Finance Committee (1965-1970}; Member of Co~ittee on Environmental Pharmacology (1975-I978). American Physiological Society (1951). American Association for the Advancement of Science (1951). Society of Sigma XI (1952). John Morgan Society of the University of Pennsylvania (1956): Life Member (1967). American Heart Association (1957): Member of Research Study Committee (1965-1967). International Union of Physiological Sciences, Section on Pharmacology (SEPHAR): Treasurer (1959-1965). International Union of Pharmacology (IUPHAR): Treasurer (1965-1966). American Society of Tropical Medicine and Hygiene (1966). International Leprosy Association (1967). American Colletge of Clinical Pharmacology: Charter Member (1971); Chairman oF Long Range Planning Committee (I976); Regent (1978-1983). Society of Toxicology (1911). Drug Information Association (1973). American Medical Association (19741. College of Physicians of Philadelphia: Fellow (1975). American Col]ege of Toxicology (1979}. BIOGRAPHICAL DATA LISTED IN THE FOLLOWING: American Men of Science Leaders in American Science Marquis World Who's Who in Science Dictionary of International Biography Marquis Who's Who in America Marquis Who's Who in the East Outstanding World Scientists, published by the U.S.S.R. Pharmacologists in the World, published in Great Britain Filipino Physicians in America Marquis Who's Who in the World Who's Who in Technology Today Personalities, published by the Italian Academy Marquis Who's Who in Science 1955 1961 1968 1970 1979 1977 1978 1980 1981 1982 1983 1984 1985 66070 =436

C Long-term Consultantships with Parmaceutical Companies and Other GrOUDS: Aviado - 5 Arthur H. Thomas Co. {Philadelphia): Selection of physiological apparatus 1953-1965 Burroughs Wellcome Co. (Tuckahoe): Sympathomimetics 1956-1960 American Heart Association (New York): Publications 1957-1962 Philadelphia General Hospital: Clincial evaluation of hypolipidemic and cardiovascular drugs 1960-1969 Mead Johnson Pharmaceuticals (Evansville): Adrenergic beta blockers 1964-1968 Warner-Lambert Co. (Morris Plains): Antiemphysematous and oral antianginal drugs 1965-1967 Vicks Pharmaceuticals (Mt. Vernon): common cold remedies 1966-1976 National Drug Co. (Philadelphia): Antitussives 1967-1970 McNeil Laboratories (Fort washington): Cardiopulmonarv drugs 1969-1977 American Chromalloy-Pharmaceuticals (st. Louis and Oakland): Veterinary and human drugs 1969-1975 Merrell-National Laboratories (Cincinnati): Antianginal drugs 1969-1972 Smith Miller & Patch (New Brunswick): Ophthalmic Solutions 1971-1972 Unimed Corp. (Morrlstown): Vasodilators and dermal preparations 1971-1972 Cooper Laboratories Inc. (Cedar Knolls]: Anti- arrhythmic, antiasthmatic and OTC products 1973-1977 Innothera Specialite Pharmaoeutique (Paris): Peripheral vasodilators 1972-1977 DuPont Central Laboratories (wilmington): Aerosol propellants and antiprostaglandins 1974-1976 Franklin Xnstitute (Philadelphia): Literature searches on adverse drug reactions 1975-1977 Bristol Myers International (New York): Analgesics and adrenergic beta blockers 1975-1977 Dow Chemical U.S.A. (Midland): Chlorinated solvents 1975-1977 Short-term Consultantships with Pharmaceutical Companies and Related Groups: Wyeth Laboratories (Wayne): Synthetic anticoagulants Sharpe & Dohme (Glenoden): Respiratory recorder Merck & Co. (Rahway): Cardiotonic drugs E. R. Squibb & Sons (New Brunswick): Antihistaminics Smith Kline and French (Philadelphia): Sympathomimetics 1950 1951 1952 1953 1954 6 0" 01437

( Aviado - 6 Short-term Consultantships with Pharmaceutical Companies and Related Groups (Cont.): Cardiological Institute of Buenos Aires (Aroentina): Cardiovascular Drugs 1959 Chemiha Farmacia (Monterey, Mexico): VasOpressors 1959 Polish Pharmaceutical Industry (Warsaw): Pharmaceuticals 1961 Sandoz Ltd. (Basel, Switzerland): Ergot alkaloids 1962 USSR Academy of Medical Science (Moscow): Soviet drugs 1963 Pfizer Laboratories (Groton): Antiserotonin agents 1964 Ires Laboratories Inc. (New York): Isosorbide 1964 Takeda Chemical Industries (Osaka, Japan): Pharmaceuticals 1965 Tokyo Cardiological Hospital (Tokyo) Cardiac drugs 1965 Cassella (Frankfurt, Germany): Intensain 1966 Knoll Pharmaceutical Co. (Whippany): Proscill~ridin 1966 Smith-Kline-French-Philippines (Manila): Phermaceuticals 1967 Iranian Ministry of Health (Teheran) Pharmaceuticals 1967 Mead-Johnson-Philippines (Manila): Pharmaceuticals 1968 Marion Laboratories (Kansas City): Cerebral vasodilators 1969 Schering Corp. (Bloomfield): Salbutamol 1969 Philippine Chemical Manufacturing (Manila): veterinary drugs 1969 Japanese Ministry of Health (Japan): Pharmaceuticals 197~ Parke-Davis (Detroit): Antimalarials 1971 Hiker Laboratories (Northridge): Bronchodilator aerosols 1972 Carlo-Erba (Milan, Italy): Antlinflammatory drugs 1972 Janssen (Belgium): Antiasthmatic drugs 1972 Cilag (Schaffhausen, switzerland): A1~inorex 1972 Slovak Academy of Science (Bratislava): Pharmaceuticals 1972 Pharmacla Laboratories (Sweden): sulfoxazole 1973 Instituto MacJonal Cardiologia (Mexico City): Antianginal drugs 1974 [ Gg0 044Z8

( C Aviado - 7 Short-term Co~sultantships with Pharmaceutical Companies and Related Groups (Cont.): Smith Kline (Philadelphia); Antitussives 1974 Philippine Heart Center far Southeast Asia (Manila): Cardiovascular drugs: 1974 Sociedad Peruano de Farmacologia y° Terapeutica Experimantale (Lima): Pharmaceuticals 1974 Taiwan National University (Taipei): Pharmaceuticals 1975 CArter-Wallace (Cranberry): Cosmetics 1975 Israel Ministry of Health (Tel Aviv}: Pharmaceuticals 1975 Philippine Food and Drug Administration (Manila): Drug regulations 1976 WilliBm H. Rorer Inc. (Fort Washington): Pharmaceuticals 1976 National Societe d'Anesthesee-Reamlnatlon (Nancy, France): /nhalational anesthetics 1976 Auerbach Associates (Philadelphia: Literature searches 1976 &earle Laboratories (Chlcaq~): Antiprostaglandins 1976 Dow Canada [Ontario): Antitusslves 1976 Roche Laboratories (Nutley): Cardiotonics 1976 Centre Mexlcano de Rstudios en Farmacodependencia (Mexico City): Dr~g dependence 1976 Midwest Research Institute ~Ransas city): Literature searches 1977 Astra Pharmaceutical Products Inc. (Sweden): Terbutaline 3977 sigma-Tau (Rome, Italy): Cetiedil 1977 Lever Brothers {Hdg@wmter): Toxicity of rug shampoo 1977 F L k 6SO?O,t439

LIST GF PUBLICATIONS Oomingo M. Aviado~ M.D. Monographs, Textbook and Dictionaries i Respiratory and Cardiovascular Reflexes (1949 - 1962) 2 Pathologic Physlo|ogy and Pharmacology of the Pulmvnary CircuIstioa (I~52 - 196~) ] Sympathomimetic Drugs (1957 ~ 1963) 5 Hypoxia and Autonvmic 81~eking Drug~ (i~60 - 1971) 6 Bronchodliators~ AntiasthmaLicg and Antitusslves (1964 - 1976) 8 Pulmonary E~hysema~ Proge~tation~i Steroids and Tobacco ~J965 - ~976) ~0 Circulatory Shock, Pulmonary Insufficiency and Peripheral Vasodilators (1965 - 1976] 1~ Coronary Vasodilstors and Csrdioective Agents (1965 - 1975)¸ 16 Pharmacoloqy and To~ici~y of New Anti-malarial Dcugs (1967 - 1972) 18 Inhslatlonal Tvxicity of Aerosol Propellnnts and 5olvemts (1971 - 1975~ 2Z Clinical PharmacoLogy and Toxicology (1975 - 197g) 24 Patent (1976) 25 Allivd Chemical Technical Reports and Reviews (1977 - 1979) 26 PosJtlom Papers foe EPA Clean Air Scientific Advisory Cornn~ittee (1978 - 1979) 2B Atmospheric Health Sciences (1980 tO present) 29 ~eview erticles are indicated by nn nsterisk (*) ~l{ others in the humberical list are reports of original investigation. " • 6807O4460

C Curriculum Vitae, Domingo M. Aviado, M.D. DMA-I LIST OF PUBLICATIONS OF DOMINGO M. AVIADO, M.D. I. MOMONGRAPHS, TEXTBOOKS, AND DICTIONARIES Drugs and Respiration. proceedings of the Second International Pharmacological Meeting, D.M. Aviado and F. Palacek, editors, Vol. 11, Pergamon Press, Oxford, pp. 1-241, 1964. Pharmacology of the Lung. Proceedings of the First International Pharmacological Meeting, D.M. Aviado, editor, Voh g, part 2, Pergamon Press, Oxford, pp. 97-193, 1963. The Lung Circulation. D.M. Aviado, Pergamon Press, Oxford: Vol. 1, Physiology and Pharmacology, pp. 1-590; Vol. 2, Pathological Physiology and Therapy of Diseases, pp. 591-140B, 1965. Oorland's Illustrated Medical Dictionary, 24th Edition. D.M. Avlado, editor of pharmacology and toxicology words, W.B. Saunders Company, 1965. Antitussive Agents. Section 27 of International Encyclopedia of Pharmacology and Therapeutics, D.M. Aviado and H. Salem, editors, Pergamon Press. Oxford, Volumes I, B and 3, pp. 1-834, 1969. B)~npathomimetic Drugs. O.M. Aviabo, Charles C. Thomas Publishing Co, Springfield, pp. 1-615, 1970. Pharmacologic Principles of Medical Practice, 8th Edition. D.M. Aviado, The Williams and Wiikins Co., Baltimore, pp. 1-1345, 1972. Stedman's Medical Dictionary, 23rd Edition. D.M. Aviado, editor of pharmacology and toxicology words, The Williams and Wilkins Co., Baltimore, 1976. Methyl Chloroform and Trichlorethylene in the Environment. D.M. Aviado. J.A. Simaan, S. Zakhari, and A.G. Ulsamer, CRC Press, Cleveland, 115 pages, 1976. Monfluorinated Propellants and Solvents for Aerosol~. D.M. Aviado, S. Zakhari and T. Watanabe, CRC Press, Cleveland, 106 pages, 1977. Isopropanol and Ketones In the Environment. S. Zakhari, M. Liebowitz, P. Levy and D.M. Aviado, CRC Press, Cleveland, 155 pages, 1977. Primary Maternal and Neonatal Health - A Global Concern. F del Mundo, E.I. Cuyegkeng, D.M. Avlado, editors, Plenum Press, New York, 544 pages, 1983, 66070h1461

( II. RESPIRATORY AND CARDIOVASCULAR REFLEXES (1949-1962) DMA - 2 i. The reflex respiratory and circulatory actions of veratridine and pulmonary, cardiac and carotid receptors. D. M. Aviado, R. G. Pontius and C. F. Schmidt. J. Phermacol. Exp. Thor. 97: 420-431, 1949. 2. The mechanism cf apnea following intravenous injection of various antihistaminic compounds; its relation to their chemical structure. D. M. Aviado, R. G. Pontius and T. R. Li. J. Pharmacol. Exp. Ther. 99: 425-431, 195U. 3. Respiratory and circulatory reflexes from the perfused heart and pulmonary circulation of the dog. D.M. Aviado, T. ~. Li, w. Kalow, C. F. Schmidt, G. L. Turnbull, G. W. Peskin, M. R. Hess and A. J. Weiss. Am. J. Physiol. 165: 261-277, 1951. 4. Early respiratory depression by curare and curare-potassium antagonism. T. H. Li, B. E. Jacobs, D. M. Aviado and C. F. Schmidt. J. Pharmacol. Exp. Thor. 104: 149-161, 1952. 5. The activation of carotid si~us pressoreceptors and i~tra- cranial receptors by veratridine and potassium. D. M. Aviado, A. Cerletti, T. H. Li and C. F. Schmidt. J. Pharmacol. E~ 115: 329-338, 1955. 6. Reflexes from stretch receptors in blood vessels, heart and lungs. D. M. Aviado and C. Y. Schmidt. Physiol. Rev. 35: 247-300, 1955. 7. Cardiovascular and respiratory reflexes from the left side of the heart. D. M. Aviado and C. F. Schmidt. Am. J. R~ 196: 726-730, 1959. 8o Parallel lines, infinity and cardiovascular reflexes. Editorial, C. F. Schmidt and D. M. Aviado. Circ. Res. 6: 229-231, 1958. 9. Some controversial cBrdiovascular reflexes, Editorial. D. M. Aviado. Circ. Res. i0: 831-835, 1962. *i0. Respiratory influence on cardiovascular function. D.M. Aviado. In: Cardiovascular Functions. Edited by A. A. Luisada, Vol. 2, McGraw-Hill, New York, 226-229, 1962. k 6SO O4462