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Bliley TI

[Record of Panel Meeting on Smoking and Health: Includes Industry and anti-Industry Positions]

Date: 19 Jun 1975
Length: 27 pages
77926-77952
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bliley_ti 00000419-00000445

Abstract

Record of panel discussion on smoking and health. Argues back-and-forth whether a link exists for smoking and disease. Questions impact of stress and disease. Examines viruses and cancer. Offers statistical examination of smokers, nonsmokers, and lung cancer. Argues that there is no causal link.

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Notes

(indexer.indexer_email WAS INVALID IN OLD DATABASE: JL)

Company
TI
Type
SCRIPT
Region
Japan
Philadelphia
United States
Sweden
France
Named Person
Aviado, Domingo M., M.D. (CTR Consultant; Special Projects Recipient)
Dr. Aviado was a University of Pennsylvania professor and did work for tobacco companies. Dr. Aviado did secret dog inhalation studies in 1970s which were apparently covered up. Dogs were inhaling. No research papers were ever done, apparently (B.C. 7/7/94).
Brownlee, A. (M.A.)
Burch, P (Ph. D.)
Cedarlof, R. (Ph. D.)
Furst, A. (Ph. D.)
Hammond, (Sc. D.)
Langston, H. (M.D.)
Levine, E. (M.D.)
Meier, H. (D.V.M.)
Ober, W. (M.D.)
Ratcliffe, Hebert (CTR Special Projects Researcher)
Industry-funded scientist, investigated lung cancer and cardiovascular disease in zoo animals, especially those maintained in an outdoor environment.
Rosenman (Dr.)
Seltzer, C. (Ph. D.)
Selya, H. (M.D.)
Selye (Dr.)
Author
Aviado, Domingo M., M.D. (CTR Consultant; Special Projects Recipient)
Dr. Aviado was a University of Pennsylvania professor and did work for tobacco companies. Dr. Aviado did secret dog inhalation studies in 1970s which were apparently covered up. Dogs were inhaling. No research papers were ever done, apparently (B.C. 7/7/94).
Brownlee, K. A.
Burch, P.
Cederlof, R.
Furst, A. (Jr.)
Hammond, E. C. (Jr.)
Langston, H. T. (Jr.)
Levine, E. R. (Jr.)
Meier, H. (Jr.)
Ober, W. B. (Jr.)
Ratcliffe, Hebert (CTR Special Projects Researcher)
Industry-funded scientist, investigated lung cancer and cardiovascular disease in zoo animals, especially those maintained in an outdoor environment.
Rosenman, R. (Jr.)
Seltzer, C.
Named Organization
American Cancer Society
Council for Tobacco Research
Harold Brunn Institute of CV Research
Harvard University of Public Health
Institute of Chemical Biology
Institute of Experimental Medicine
National Heart and Lung Institute
National Institute of Public Health
New York Medical College
University of Chicago
University of Illinois College of Medicine
University of Pennsylvania
Subject
Health Effects
lung cancer
Nonsmokers
Statistical Data
tobacco use
cancer

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Page 1: 00000419
'"SMOKING AN~., HEALTH: THE ,NEED T__O MOW" NARRATOR: This is America today--the pace fast...the competition great. We live with more tension, more emotion, more concern about our health, more everything than ever before.' DR. ROSENMAN: In our type of socioeconomic environment, the environment of the industrialized world, if you wan "° to achieve more and you have more obstructions, traffic,~ '" persons, things, what do you do today? Well, either yo.~.Z become more frustrated or you hurry.. • DR. SELl"E: You use up energy to resist an infection, to fight intoxication. You use up energy to think. And the more energy you use, the more you are under stress. D_~R. RATCLIFFE: What we are doing to ourselves is what's killing us off at an unnecessarily early time. " .NARRATOR: ..In this--m&mwelo~--mech~n~e~age~4~, . u~.su~t of te~hnml/,gical-.adVancemen~T~h~O~~s~it CONFIDENTIAL MINNESOTA TOBACCO UT GATION TIMN 0077926
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---
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• " .. .... CONFIDENTIAL. ' .~ on to pay somewhere~e~.~e~~s whatf ~-~--~-- seems like progress' 'i create new pro s to be s~~a~o_ur very For the next few minutes, we will be examining our stress- ful souiety: what it's doing to us, ~nd ~he. :kmpact of our t~tal behavior on our health. Specifically, we will be . . looking into one of the more controversial a~pects of modern life: tobacco and its use, p.articularly in c-gare--esl uu ~" --" "" / ,, - To help us gain new perspective on the question of 1 smoking ~nd health, w~ will hear from world-r~n.owned . &..scientists and experts. ,.~v~s~ ~oI~ o~ ~;~,~c~,~s: { '. .~" • ,,,~.....~ K. Alexander Brownlee, M. A., Retired .~~ate Professor~ of Statistics, University of" Chicago .-. Rune Cederlof, Ph.D., Associate Professor of Environ- mental Hygiene, National Institute of Public Health, Stockholm ~ ;) Arthur Furst, Ph.D., Director, Institute of Chemical Biology, University of San Francisco ~0 ~3 TIMN 0077928 CONFIDENTIAL ~" 00213~6 MINNESOTA TOBACCO LITIGATION ~v~I,EG~ ~ CONFIDENTIAL
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• ' CONFIDENIi :. E. Cuyler Hammond, Sc.D., Vice President for ~idemiology and Statistics, American Cancer Society-'~-'{~,~ Hiram T. Langston, M. D., Thoracic Surgeon and Professor of Surgery, University of Illinois Colleg_~.of Medicine Edwin R. Levine, M. D., Director, Department of Inhala- tion Therapy and the Cardiopulmonary Laboratory; Edge- water Hospital, Chicago , ~%~ "11. ~, .. Hans Meier, D.V.M., Senior Staff Scientist, Jackson Laboratory, Bar Harbor, Maine, and member of "Scientific Adviso~ Board, Council for Tobacco Research ~ ' William B. Ober, M. D., Clinical Professor of Pathology, Herbert L. Ratcliffe, Sc.D., Pathologist ~d Professor ~eritus, University of Pe~sylv~ia ~,~ Ray Rosenman, M. D., Associate Director, Harold Brunn Institute of Cardiovascular Research, San Francisco Carl C. Seltzer, Ph.D., Senior Research Associate in Biological Anthropology, Harvard University School of Publi~ Health </,~, ~'~. ~, ? TIMN 0077929 CONFn~E~CrtAL "V 0021377 MIIN1NESOTA TOBACCO LITIGATION ~EG~D AND CONRDENTIAL ProCeed as requiredl~y~ ~Court's March 7, 1998 Or,~er ;11 State of Minnesota, ._: ~]. v. Philip Morris, et al Court File No.: C1-94-8565
Page 5: 00000423
M~OTA TOBACCO LITIGATION . • . -." ,~u.. H~s Selye, M. D., Director, Institute of Experimental Medicine ~d Surge~, University of.Montreal) ~e hectic lives we lead today is considered by some ~o be a direct contributing factor to the t~e of disease one wall die from. Dr. Hans Selye is a world-respected expert on the stress • - of life. By-stress, he means the rate of all wear and tear oausedby life. DR. SELYE: There are certain responses--disease responses-- which are not due actually to what we'think is the disease-p~oducing agent, but to our body's defective response to it. Cardiac disease, hypertension, cer- • tai~ types of so-called alleygic disease. Inflammation..)" L~ sive reactions of our body against insults which do not re~ire such ~ excessive response. ~ ~l~z&aca~ - ~
Page 6: 00000424
• .: ,~,~,~ ~ ~ . philip ~ . •~ ,~anesot , 565 : -5- • .... l • -.. CONFIDENTIAL. ~ D l LTZE.R: It's very serious, the single highest--------7 V ~ ategory of disease. S xty percent of the men who die/ ~n, this country die frol heart disease. " . / NAR TOR: Naturally, animals are not the same a/human ~ " d cannot necessl~rily be compared expJlmentally.. / But the~ have been--thrDughout the histo y~f medical, research-~nstances wher, the results of./ nimal experil ments and ~imal .observation have hel~ ~ us .to understand '" ~RRATOR: ~. Heart is an expert, on. animal ' ' r.esponseto stressfu~ ..For example, in on~ • experiment he radical: a flock of chickens, which normally consists ~ rooster and a great many hens. He divided t~e into different sized groups with a ~n acl two roosters to every hen. The resu~ ~egan killing off the males. The hearts were badly damaged." The conclusions / .DR. Animals p~laced in )ns where they are ~le to carry out aI behavior ~ is . stic of the spe~cies--where their is be expected to develop heart d to die of heart disease. And this we can to the primates, includin the gorillas, which are, think, about as close to man as any other animal is. | TIMN 0077931 CONFIDENTIAL -/- 00~13~9 MINNESOTA TOBACCO LITIGATION
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~,.~: .~s~;~,Court File ~ No.:ai' V.c1.94_8565 Philip Morns, e~ ,~. ~m~n---c-i-tu ati :n ~- ~ we ~r~ ho~m~in much " ~ .... ~TOR: The second ~=--~ ~7~ ~ .I" ~s c~cer. A S~ply stated, c~cer is. a m~i~t gro~h somewhere in ~e body which tends to spread~t t~.z often ferret i& --'~ ~.--~~ith._the. spreading., of..tha~-. ~no~i~~cer, laterally, c~ attack ~y p~t or el~t of the ~atomy. ~ere ~e c~cers in the l~ph syst~, blood c~cer, ~_~ne c~cer, brain c~cer, skin c~cer. . , . . , ~_~ ~. FU~Tx ~en does a group of tissues become ~no~al~ ~ So far we haven' t the slightest ide~. does a nodal ./ cell which grows the no~ way, divides the no~ way, why does a single cell of this suddenly ch~ge into a c~cer cell2 • " T~N 0077932 COffeE.TIlL . ~~SOTA TOBACCO LITIGATION ( 0021380
Page 8: 00000426
read, o~~$nq--as so m~y peo~t~ " "~~ ~o=t. ~.he cause of cancer, I think we should spe~ of NA~TOR: NeW discoveries suggesting vi~ses as possible causes of some t~es of c~cers have ~cited the scientific ' ~ ~ At the Jaukson L~orato~ ~n Bar Har~r, Maine, Dr. H~s Meier ~d his collea~es ~ mice different kinds of c~cers. DR. MEIER: rinses do cause cancer. We are working on g~es which control certain cellul~ compo~ds which we c~l r~onucleic acid. It's like a vies by physic~- ch~ical ~d biologic~ b~avior. It is unl~e the co,on t~e of vies in that it is not tr~smitted horizont~ly from individual to individual, but it is the product of each individual ' s inherit~ce. NA~TOR: Others have noted ~ app~ent g~etic suscepti- bility to c~cers. For ~ple, ~ ~ex~der Br~lee, CONFIDENTIAL MINNESOTA TOBACCO LITIGATION TIMN 0077933
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PRIVILEGED AND CONFID~AI+ " - ~ u. • : ~:~.,+:-~.~ Court's March 7,1998 Oni~ • ' ~ + ~J~ ~v~_..::, :c.- ~,,. :~ al. v. Philip Morris, et al, ,.' ', Court File No.: C1-94-8565 -8- .... iFIDENTIAL -~ --- ~ ~-~1~l-~--dC ;;3a associate prb£essor" o£ st~t±sties ~t the Un£versity o~ Chicago-- PROF. BROWNLEE: There have been studies for ethnic groups in the United States, ethnic groups moving in as a body from various European countries. It is found that the lung.cancer rate for these ethnic groups corresponds more closely with their original European compatriots than with the general U. S. population. This strongly suggests a •strong genetic component of this dis6ase. I In recent years, no more ~estions, more controversy, th~ c~cer of the .--- "+ ...... ~ "~ ~+ int~.:ifi~ lung. ~I~ ~wo~,,~ :f _..iz ....... i ~th " ......... " app~t statistic~ association between smoking T ~021382. CO E IaL •
Page 10: 00000428
produce t~ese statistics was cc~ri~e~ ccm~ G~,~OC ''"'i .............. u_n_nzrc __ - the ~eric~ C~cer Society. ~ey selected more th~ a million men women ~=~- ~],~ -.-~.. ~r no to fill out ~estionnaires ~out their health, past illnesses, smoking ~d other aspects of living. The material was then turned over to ~. C.uyler Hammond, the chief statistician for the American Cancer Society~ DR. HAMMOND: ...And I had our compute~ do a matching prob.lem. I, for this analysis, took the records of men who'd never smoked re.gularly an~ the records of men who'd smoked 20 or more cigarettes a day. Then I had the computer take the first man who'd never smoked regularly and look through all the files for a smoker who was as much like him as possible. "~_ h ~ ' ~ ~£~.-~ TI N 7793S CON ENTI 0031383 MI OTA TOBACCO LITIGA ON
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m_en ~na-~.~mok~ z-,--~noth~r - ~-n~..~ ker;, --wh~er ~ -&l.ike--~.-~k-- ,.Ozl-a~l,-thes~, other, thi~gs~ ~.~ . ,..,. .................................... , At the end of 44 months, there were 600 ~d some deaths in the nonsmokers ~d 1300 ~d some deaths in the smokers. ~out 15 or 20 times as m~y smokers as nonsmokers had died of l~g c~cer. . [m~[ highly respected m~ers.of the scientific co~un~ ~rom the Ve~ ok-v~gorous exception to the statistic~ methods ~d how the n~ers were use~. For. ~ were from ~! .cz~n_i~~ ~, .... ~ '.~Z"~ ~-l .... " ...... " ' -, Z~!~ ~ ~tazt~n--:~--- fc~ the ~dustrial northeast ~d midwest ~d virtually none from the ~tain states. ~R. 0BERt L~g c~cer is predo~n~tly.a disease of people who live in large cities or in industrial ar~as, whereas people who live in ~ral co,unities have a much lower incidence of lung c~cer. CO~ENTIAL • . ~00a~S4 M~OTA TOBACCO LI~GATION TI N 0077936
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.PR.OF. BROWNLEE: The Hammond Survey for the American Can.cer Society suffers from the defect there was no/ a / properly defined population. So we just don't kn~w what the population was. / • .. / | / DR. EYSENCK: The ordinary statistical met s that have been use~. are really quite worthless. The/y don' t prove | anything a~ all, except that there may/. may not be a / relationshipJ _ , / ., DR. ,OBER: The actual number of cases of lung cancer-- . although recognizable and significant--is not terribly,. ~/~ / t.erribly.large, ,whereas the ~umber. of. people who smoke / ~lgarettes is extremely larg~_. And any theory which '(~~~"~'. ' explains why A causes B also has to "explain why A does ~ ~¢~ not'cause B in the people in whom it does not occur. • And this is the one thing which these people have not ~ ~ explained. It's an incomplete theory. .N RRATC,~. ~ ~7~ ,,=~ -expia~neu.,wny une ~'~rted death. rate from all~ypes of respiratory, diseases has steadily. declined sin/e 1900, while cigarette consumption has d/n " "" increase almost directly opposite~ proportions. / ' " "' " ny.~. low.nce is made by proponents of the smoking-lung ~for other possible causes of cancer'of~t~h~ CO~ENTIAL • MINNESOTA TOBACCO LITIGATION ~r'00213~
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.. . PRIVILEGED AND CONHDE~ " - i."~iced as required by t1~ ~ourt's March 7,1998 Order State of Minnesota, et al. v. Philip Morris, et aL - 12- ~ Corot File No.: C1-94-856~ ,DR. LEVINE: There are substances in the air in every city in the United States--and I suspect in every city in the world-=which are.known to produce cancer. ~ Herbert ~ Rateliff~has noted a si~ifie~t inergase in the fre~en~ of l~g c~cer ~ water fowl--especially in two species of ducks at the Philadelphia zoo--located in a t~ic~l city air pollution ~ea. s s~le ~at they were ingesting materxal ~at has be~ deposited in this mud ~d that ~cretion by way of ~e lungs is a possible ~it of the carcinog~s ~at are t~en in through the mouth. CO~ENT~: T~ 0077938 M~SOTA TOBACCO LITIGATION
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The other possibility is that they are inhaling it. If SO~ they seem to be peculiarly susceptible to inhalation Of carcinogens. Siberi~ tiger died in the Philadelphia zoo. Cause of death as dete~ned by autopsy: c~cer of ~e lung. Others point out additional factors statistically associated with the disease. ~ere's the matter of a. marked differ~ce of the rate by sex. ~G~TON: ~is disease is a male disease. It is DR. six or eight to one in favor of m~es. Wom~ do get the disease, it is t~e. But £hey do not get it wi~ the s~e fre~ency as the m~e. ~~ .... =~ain~-rather constant. It has .not increase, ~d ~~n~.~s-.t~ng ~out the m~ked ri~e in th~ incid~ce- ,. M~SOTA TOBACCO LITIGATION
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'"-, ~ D-~dT,'. . ,~, .'d'-li :~--I~,| ~e same " w~agent, that one has ass~ed--~ote--~epid~ic .... NAR~TOR:. ~other ch~lenge has be~ base,on how you measure what really caused a person's dea~. Dia~ostic ' cap~ility wi~ respect to c~cer of th/l~g is a re- latively recent develo~m~t. " y . " g~ools .now for diagn " as to what ~e prev~ce~f l~g c~cer was at ~at. . p~cul~ t~e. . . • . / .. ..• . . . ~TOR" Most mot ity stat~ti~ in ~e cig~ette' . . ~ity ~tat~ti~ in ~e cig~ DR. OBER: / dea~ ce~ficates ~otoriously ~less akrerson ~as ~een ac~rate./~ ~e first place, ~ffi~l~e~ sure antopsi~, somet~es it' s v~ whiP, died of. ~ " ~ ~" ~TOR: ~at ~st~es ~ght occ~ ~ d~a~o~s "of /g c~cer based only £n death c~ifica~es?. ~ CO~E~I~ ~~so~ ~o.~cco u~,6~,o~ T~N ee7794e
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, ~d m~y c~cers arising in other parts of ~ body ~el I filtered ou~ ~d ~ deposits--~hieh are ~alled , metastatic c~cer--in the lung. ~at are diagnosed as ~ c~c~r without ~utopsy may not be lung c~cer ~all, but c~cers in o~er org~s.. .~R. OBER: ~n I read ~ article in the medical litera~re whlch i~..~ased upon death certifZcates I stop readifig it'~ ~ bec ere's no point in my wasting my t~e. ~"~ve ,.,I/er thlngStion, to read which, are based on. . a fi=er founa~-; ~R~TOR: 'Though th: mo~t :t::klng associatlu** One =zaz_~:z=:.:i.. -- corona~ illness. ~ we fo~d that there were2more th~ twice as m~y s~kers ~at died of heart disease as nonsmokers. " N~TOR:/ M~y ~dversaries of smoking support~ '~ view. Oehers ~e not satisfied with ~his s~ple conclusion. ' 007794 CO~E~L ~ , M~SOTA TOBACCO LITIGATION
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~: Few people ~e~i~e that actually the.j..~ ,~tatistic~l risk so-called which has been given~it by "~~lic He~th Se~ice of heart disease o~'~i~okers t~ States, J~p~ ~d Switzerl~d--~h ~rom arteriosclerosi~ ~t~ 1955~~- ~hile it was rising by more~ 30 percen~ ~ such/. "~ow-cig~ette-cons~ption. . . . coun tries~weden,. "~ " ~ ~s we've seen w~ ~espec~ ~o lun~ ~ce~,~e of statistics ~ l~ted. ~e . S~geon General's repo .... had a& much specific~ly stated that statistical methods c~ not est~lish proof of a causal relationship in ~ associa- tion. Yet ~ere were some whosy n~tural desire to fi~ ~. ~% .... ~t~j' z-1~z.- 1 Aii~h~zrt fizt--- ~ay have led ~ to disreg~d ~is caution. " el aft .... _~9"~ ~~d .ee~.. hea=%- dlseas~. . - TI N 0077942 CONFmENTIAL ~ 00Z~S0 M~SOTA TOBACCO LI~GATION
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/~ ............................ Natlonal Heart and Lung Institute points out that we've learned so much ~bout how to treat heart ailments that we overlook how little we "know about their causes. "We tend to obscure our ignorance, " t~e Institute says, "by making it seem that a problem has been so'ived when it has, in fact, Only been half-solved." FFdV~EGED AND CONFIDENT!~.y. ~ as required by the Cohort's ~',.~,~ ~ . State of Minnesota, et al. v. Philip Court File No.: C1-94-8565 CONFIDENTIAL MINNESOTA TOBACCO LITIGATION TIMN 0077943
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~igarette. smoki~and corona~isease,- I. think we~ . . -1969 -- The~eric~'Hea~ ~s earch director . ',told Congress~/ "Let's be sure we ~derst~.the. Heart ~Associati'o/~osition: We do not .say that we ~ave • . . . ,data says. cigarett~ smoking causes coron~ / ~ui~.~).. ', ..... -. ~ ... ~.~uk'-::~? What avenues 'of meaningful research should be explored if the answers aren't all in? ,. Many authorities feel that more attention should be given to the smoker rather .than the smoke. What kind of people smoke and why? Do they differ from those who don't smoke? DR. SELTZER: Smokers tend to be more agressive, outgo£ng, - extroverted people--hard driving, full. of tension. They tend to marry more often, divorce more often, move their houses more often, change their occupations more often ~han do nonsmokers. TIN~N 0077944 CONFIDENTIAL .'~-00~139Z MINN~OTA TOBACCO LITIGATION ?RI~LEGED _Cou~ File No.: C1-9@BF6~
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DR. SELYE: The human being smokes only because he likes to smoke. Nobody smokes because he .h,as, to smoke. "J~L~d ,~-~-~ emmet.-.-~ ~o~ ~o smoke. Su £~ l-~i~,, i-~-i~ ~ d~~ ~:to~l oth~~~~~ .... ~---,~ ..... , .... ~' .~,' DR. CEDE~OF: Say that you are a certain t~e of person ~d you like to..s~ke. You may also then be:.more apt to start driving or more apt to h~ve a stressing job or something like that. . NAR T~R: ~or the past several years, Dr. R~e Cederlof of Sweden's National Institute of P~lic Heal~ has studied the effect of smoking ~d ..... -- . ~ , ~ % ~. C~E~OF:~ Ye~ ~w. we did ask for a lot of other ~~a~-~.~.~~ ex~ ~a for.. d~e,~. smok~r,,.i~,monozyg~ca=that is id~tical-~twi~s ~i1~-"~ " ... . ~would. ~"up what we have found here in such a ~ay ~at ._S_~k~ng.does not se~ to cause he~t disease, that is the' ~d_.~-heart disease we are studying--u6rona~ heart - ~.' CONFmENTI 00 13 3 M~SOTA TOBACCO LITIGATION TIMN 0077945
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........ There seem to be other ex- planntions for it, ~nd we are trying of course also to see what other explanations are there. NARRATOR: Dr. Ray Rosenman .is director, of what is called the WestErn Collaborative Group Study. He has found a striking association between behavior types and heart disease. , -~an--be - di-~i~--i~to-beh a%~iom- ~y~ e.~A- -an ~-,~avi~ z~Typ~~ B-. .... DR. ROSENMAN: The behavior pattern that we're studying is concerned first with personality attrib~tes--such as aggressiveness, ambition, drive--the drive to achieve, the drive to get things done--competitiveness. Type A individuals are simply individuals who exhibit most or all of these different personality facets to an erahanced degree - an exaggerated degree. In general, the Type B individual is much more relaxed, much more easy-going, ~sn;.t constantly-pay attention Co .the clock.S_eel_-_' ~ ~.nv~~- .~...- ~- ~a ~_-~ .t--'-~.~--~r~_s-~- .E~r£tc-doesn~-ten-d"~o ~"to "bed"at ~ight or ~ke. ~/p -i-n. ......... ~.~e._m.o__r..~i~g planning.-~-their day ~, ,squeeze-more ou~f exery minhte. ................. • TI N 8.77946 CONFIDENTIAL 7- 0021894 MINNESOTA TOBACCO LITIGATION
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Drl Rosenman and his associates concluded: DR. ROSENMAN: Men with the Type Acoronarybehavior patternmen o Ymoro with the T~e B behavior pattern. . . ~ all .,,a. i~ -~----~ ~- -' u pereen~ were T~~d ~=~-~.~ ~ght ve~ well expect, the ~ehavior patte~ is related to the smoking h~it. ~TOR: ~e Surgeon General's report relat~ a higher dea~ rate to smokers th~ nonsmokers in more th~ 20 different ~eas--including accid~ts ~d suicide. Let's. look at just one more. ~phys~a. Simply stated, emphysema occurs when the lungs lose their elasticity so that it becomes progressively more difficult to breathe. Opinions vary about any role played by cigarette smoking. •. 7"0021395 CO FtOENTIAL TIMN 0077947 MINNESOTA TOBACCO LITIGATION
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DR. HAMMOND: Emphysema in the United States is caused primarily by smoking and it's a major cause of disability. LEVINE: Wail, my feeling is that there is no eQidence that cigarette smoklng has a dlrect causal relatlonshlp ~e origin of ~phys~a is shrouded in a great deal of ~ste~, ~d ~e only method ~at has been successful to ~e blood vessels which are nutrient to ~e l~g. ~TOR: A recent gove~t repo~ su~ed it up by obse~g "that "s~ce there are no claret-cut leads as ta ~ cause or causes of ~phys~a, no ~ick solution to ~e probl~ c~ be ~ticipated.~~y complex ~est~o~s r~n to be ~ered. " TIMN 0077948 CONFIDENTIAL
Page 24: 00000442
D,R. AVIADO-" (page 6, new Aust. film) I have examined all the articles rela ing to this subject, reviewed each one carefully, and I have come ~o the ~ conclusion that there is no evidence at all that a healthy nonsmoker suffer from being exposed to cigarette sm.oke~ rch PRIVILEGED AND CONFIDENTIAL Fr~uced as required by the Court's March 7,1998 Order in State of Minnesota, et al. v. Philip Morris, et al. Com~ File No.: C1-94-8565 CONFIDENTIAL MINNESOTA TOBACCO LITIGATION TIMN 0077949
Page 25: 00000443
DR. S TZER: i think where we stand now--the hes say--is we d6 not know whether or not there is.,a causal . relationship between smoking, and heart .d~s~ase. Neither does the Public' Health Service know. /~"do I _.-. ,. I /- ' . / .. -, DR. LEV~NE: There a~'large n~ers o~ ~s, who hav~ some "' ~a~kgzouna in th~s field, who do not ~eli~v~',t~e . ~A~OR: ~ou~ gene=~l statistical associations o~ /~[ OBER: I th~ we have a great deal to le~. ~d I /~ far too m~y people have ~s~ed to a pr~ature. ~jud~t based upon ve~ .inade~a~e evid~ce, chiefly . kbecause of ~e. tr~dous ~otion~ need to oversimpli~ '~ ~d to m~e ~ings easy ~d palat~le for the public, for ~dic~ students as well as for legislators. , . / ~. • .,. . _ • . : ~:.'~li~te lun~ c~ncer~ c~rdio vascular dis~se~ ~nd so on. ' ~'~'::':" ' " ~00~1398 CO~ENTIAL TIMN 00779 0 M~SOTA TOBACCO LITIGATION
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w " ' expect a speedy breakthrough here --say ~~ ,._r_ hre~throuqh, T . od ide ~.~~ ~.~ hi k..~ . - .... ~ ~-~',~--~, ,~ ~ ~ ~ ~ ~*~!~'' - - "~ "~ ~___--" ~ _ ~w~,~ ~,~ ~'~ ~&;~ As our society accelerates at ~ ~ncreasingly ffaster pace ~d grows more complicated, we ~ ~ e fforced to seek ,t~e ~swers, based not on statistic~ coincidence but on me~ng~l rese~ch into causes% ~s mor~~s~vi~St- ~-~v~t~eth ye~, ~e"~" ~u~h~ ~e-f~hat~o~ factors-prod~..~.-~&~e~e~,-~- , ~f~yin@ ~i~ dinner-people :. .in. d~fer~t behav~q=~-~ ~S~ ~on~. men-a~ ag~nst womb, . differe~t_e~!~ ........... ~, ~~"~Dng'~pl~"w~th diffe£~nt ~iet~--h~i.ts~_ ;,. ..,....~ CONFIDENTIAL MINNESOTA TOBACCO LITIGATION TIMN 0077951
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• PRIVILEGED AND CONFIDENTIAL ,._ - -... l~++~uced~ StateaS requiredby the Court's=_ March 7,1998 Order , . -. of Minnesota,.et al..v. Philip Morris, et .. - Court File No.: C1-94-8565 NARRATOR: The tobacco indust~ ~s conceded ~out the ~plica£ions for its products. Xt ~elieves info~ed , discussion is essential to the p~lic interest. Xts ~c .sc~tif~c research ~ in the, ~ea oZ smoking ~d . ~ ~ ~h~ng we need is a good idea. We need more good ideas ~d we need more go~ ~ality research. CONFIDENTIAL MINNESOTA TOBACCO LITIGATION - + TIMN 0077952 ~ 00Z~400

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