Tobacco Documents Online

'"SMOKING AN~., HEALTH: THE ,NEED T__O MOW" NARRATOR: This is America today--the pace fast...the competition great. We live with more tension, more emotion, more concern about our health, more everything than ever before.' DR. ROSENMAN: In our type of socioeconomic environment, the environment of the industrialized world, if you wan "° to achieve more and you have more obstructions, traffic,~ '" persons, things, what do you do today? Well, either yo.~.Z become more frustrated or you hurry.. • DR. SELl"E: You use up energy to resist an infection, to fight intoxication. You use up energy to think. And the more energy you use, the more you are under stress. D_~R. RATCLIFFE: What we are doing to ourselves is what's killing us off at an unnecessarily early time. " .NARRATOR: ..In this--m&mwelo~--mech~n~e~age~4~, . u~.su~t of te~hnml/,gical-.adVancemen~T~h~O~~s~it CONFIDENTIAL MINNESOTA TOBACCO UT GATION TIMN 0077926

---

• " .. .... CONFIDENTIAL. ' .~ on to pay somewhere~e~.~e~~s whatf ~-~--~-- seems like progress' 'i create new pro s to be s~~a~o_ur very For the next few minutes, we will be examining our stress- ful souiety: what it's doing to us, ~nd ~he. :kmpact of our t~tal behavior on our health. Specifically, we will be . . looking into one of the more controversial a~pects of modern life: tobacco and its use, p.articularly in c-gare--esl uu ~" --" "" / ,, - To help us gain new perspective on the question of 1 smoking ~nd health, w~ will hear from world-r~n.owned . &..scientists and experts. ,.~v~s~ ~oI~ o~ ~;~,~c~,~s: { '. .~" • ,,,~.....~ K. Alexander Brownlee, M. A., Retired .~~ate Professor~ of Statistics, University of" Chicago .-. Rune Cederlof, Ph.D., Associate Professor of Environ- mental Hygiene, National Institute of Public Health, Stockholm ~ ;) Arthur Furst, Ph.D., Director, Institute of Chemical Biology, University of San Francisco ~0 ~3 TIMN 0077928 CONFIDENTIAL ~" 00213~6 MINNESOTA TOBACCO LITIGATION ~v~I,EG~ ~ CONFIDENTIAL

• ' CONFIDENIi :. E. Cuyler Hammond, Sc.D., Vice President for ~idemiology and Statistics, American Cancer Society-'~-'{~,~ Hiram T. Langston, M. D., Thoracic Surgeon and Professor of Surgery, University of Illinois Colleg_~.of Medicine Edwin R. Levine, M. D., Director, Department of Inhala- tion Therapy and the Cardiopulmonary Laboratory; Edge- water Hospital, Chicago , ~%~ "11. ~, .. Hans Meier, D.V.M., Senior Staff Scientist, Jackson Laboratory, Bar Harbor, Maine, and member of "Scientific Adviso~ Board, Council for Tobacco Research ~ ' William B. Ober, M. D., Clinical Professor of Pathology, Herbert L. Ratcliffe, Sc.D., Pathologist ~d Professor ~eritus, University of Pe~sylv~ia ~,~ Ray Rosenman, M. D., Associate Director, Harold Brunn Institute of Cardiovascular Research, San Francisco Carl C. Seltzer, Ph.D., Senior Research Associate in Biological Anthropology, Harvard University School of Publi~ Health </,~, ~'~. ~, ? TIMN 0077929 CONFn~E~CrtAL "V 0021377 MIIN1NESOTA TOBACCO LITIGATION ~EG~D AND CONRDENTIAL ProCeed as requiredl~y~ ~Court's March 7, 1998 Or,~er ;11 State of Minnesota, ._: ~]. v. Philip Morris, et al Court File No.: C1-94-8565

M~OTA TOBACCO LITIGATION . • . -." ,~u.. H~s Selye, M. D., Director, Institute of Experimental Medicine ~d Surge~, University of.Montreal) ~e hectic lives we lead today is considered by some ~o be a direct contributing factor to the t~e of disease one wall die from. Dr. Hans Selye is a world-respected expert on the stress • - of life. By-stress, he means the rate of all wear and tear oausedby life. DR. SELYE: There are certain responses--disease responses-- which are not due actually to what we'think is the disease-p~oducing agent, but to our body's defective response to it. Cardiac disease, hypertension, cer- • tai~ types of so-called alleygic disease. Inflammation..)" L~ sive reactions of our body against insults which do not re~ire such ~ excessive response. ~ ~l~z&aca~ - ~

• .: ,~,~,~ ~ ~ . philip ~ . •~ ,~anesot , 565 : -5- • .... l • -.. CONFIDENTIAL. ~ D l LTZE.R: It's very serious, the single highest--------7 V ~ ategory of disease. S xty percent of the men who die/ ~n, this country die frol heart disease. " . / NAR TOR: Naturally, animals are not the same a/human ~ " d cannot necessl~rily be compared expJlmentally.. / But the~ have been--thrDughout the histo y~f medical, research-~nstances wher, the results of./ nimal experil ments and ~imal .observation have hel~ ~ us .to understand '" ~RRATOR: ~. Heart is an expert, on. animal ' ' r.esponseto stressfu~ ..For example, in on~ • experiment he radical: a flock of chickens, which normally consists ~ rooster and a great many hens. He divided t~e into different sized groups with a ~n acl two roosters to every hen. The resu~ ~egan killing off the males. The hearts were badly damaged." The conclusions / .DR. Animals p~laced in )ns where they are ~le to carry out aI behavior ~ is . stic of the spe~cies--where their is be expected to develop heart d to die of heart disease. And this we can to the primates, includin the gorillas, which are, think, about as close to man as any other animal is. | TIMN 0077931 CONFIDENTIAL -/- 00~13~9 MINNESOTA TOBACCO LITIGATION

~,.~: .~s~;~,Court File ~ No.:ai' V.c1.94_8565 Philip Morns, e~ ,~. ~m~n---c-i-tu ati :n ~- ~ we ~r~ ho~m~in much " ~ .... ~TOR: The second ~=--~ ~7~ ~ .I" ~s c~cer. A S~ply stated, c~cer is. a m~i~t gro~h somewhere in ~e body which tends to spread~t t~.z often ferret i& --'~ ~.--~~ith._the. spreading., of..tha~-. ~no~i~~cer, laterally, c~ attack ~y p~t or el~t of the ~atomy. ~ere ~e c~cers in the l~ph syst~, blood c~cer, ~_~ne c~cer, brain c~cer, skin c~cer. . , . . , ~_~ ~. FU~Tx ~en does a group of tissues become ~no~al~ ~ So far we haven' t the slightest ide~. does a nodal ./ cell which grows the no~ way, divides the no~ way, why does a single cell of this suddenly ch~ge into a c~cer cell2 • " T~N 0077932 COffeE.TIlL . ~~SOTA TOBACCO LITIGATION ( 0021380

read, o~~$nq--as so m~y peo~t~ " "~~ ~o=t. ~.he cause of cancer, I think we should spe~ of NA~TOR: NeW discoveries suggesting vi~ses as possible causes of some t~es of c~cers have ~cited the scientific ' ~ ~ At the Jaukson L~orato~ ~n Bar Har~r, Maine, Dr. H~s Meier ~d his collea~es ~ mice different kinds of c~cers. DR. MEIER: rinses do cause cancer. We are working on g~es which control certain cellul~ compo~ds which we c~l r~onucleic acid. It's like a vies by physic~- ch~ical ~d biologic~ b~avior. It is unl~e the co,on t~e of vies in that it is not tr~smitted horizont~ly from individual to individual, but it is the product of each individual ' s inherit~ce. NA~TOR: Others have noted ~ app~ent g~etic suscepti- bility to c~cers. For ~ple, ~ ~ex~der Br~lee, CONFIDENTIAL MINNESOTA TOBACCO LITIGATION TIMN 0077933

PRIVILEGED AND CONFID~AI+ " - ~ u. • : ~:~.,+:-~.~ Court's March 7,1998 Oni~ • ' ~ + ~J~ ~v~_..::, :c.- ~,,. :~ al. v. Philip Morris, et al, ,.' ', Court File No.: C1-94-8565 -8- .... iFIDENTIAL -~ --- ~ ~-~1~l-~--dC ;;3a associate prb£essor" o£ st~t±sties ~t the Un£versity o~ Chicago-- PROF. BROWNLEE: There have been studies for ethnic groups in the United States, ethnic groups moving in as a body from various European countries. It is found that the lung.cancer rate for these ethnic groups corresponds more closely with their original European compatriots than with the general U. S. population. This strongly suggests a •strong genetic component of this dis6ase. I In recent years, no more ~estions, more controversy, th~ c~cer of the .--- "+ ...... ~ "~ ~+ int~.:ifi~ lung. ~I~ ~wo~,,~ :f _..iz ....... i ~th " ......... " app~t statistic~ association between smoking T ~021382. CO E IaL •

produce t~ese statistics was cc~ri~e~ ccm~ G~,~OC ''"'i .............. u_n_nzrc __ - the ~eric~ C~cer Society. ~ey selected more th~ a million men women ~=~- ~],~ -.-~.. ~r no to fill out ~estionnaires ~out their health, past illnesses, smoking ~d other aspects of living. The material was then turned over to ~. C.uyler Hammond, the chief statistician for the American Cancer Society~ DR. HAMMOND: ...And I had our compute~ do a matching prob.lem. I, for this analysis, took the records of men who'd never smoked re.gularly an~ the records of men who'd smoked 20 or more cigarettes a day. Then I had the computer take the first man who'd never smoked regularly and look through all the files for a smoker who was as much like him as possible. "~_ h ~ ' ~ ~£~.-~ TI N 7793S CON ENTI 0031383 MI OTA TOBACCO LITIGA ON