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C"O N F'I D E N T I A L R.J.Reynolds Tobacco Company Winston-Salem, NC. 27102 ,..lune 11, 1979 Dr. Herbert R. Bentley IMPERIAL TOBACCO LTD. Lombard Street Bristol BS99 7JR England Dear Herb: Thank you very much for sending me the minutes of the Brussels meeting as per Veronica's letter of May 22nd. I distinctly remember that I mentioned during the discussion of the minutes, that I would like to have our contribution to testing the ICOSl sampler mentioned more specifically. You will recall that I sent you a copy of our report on these test~ well prior to the meeting and that this memorandum was distributed during the meeting. I would appreciate very much If you could please make a correction to that effect in the minutes. Off the record, regarding further work on our part on the ICOSI-Reemtsma sampler, I am awaiting the progress reports which I hope will be forthcoming at our August meeting. If, at that time, the ICOSI sampler still should require any sub- stantial development work, before being usable by a contractor-testing laboratory, I may want to recommend our working on it again. For the future, I am planning to recommend that the Stanford machine be used whenever the proprietor of. an establish- ment, such as a restaurant, etc., has no objections against its use in spite of its bulkiness, but to recommend the use of the ICOSI sampler for nicotine and the Carreras syringe for CO whenever such permission for usage would only be given for such less bulky equipment. I am enclosing coverpage, etc., of an American Government document, which has obvious relevancy to our interest, even though the "science" may be questionable. The full report Ss available upon request. I also enclose some documents on nitrogen dioxide, which may be relevant to our needs in the future. However, nobody here has checked these for accuracy, etc. You may recall that Helmut talked to us in Brussels about a meeting of the German Cancer Institute in Heidelberg on "Nitrosamines in the Environment" on May 21-23~ I have obtained the following information on this: Brunnemann reported sidestream values of about one third of those reported earlier by Hoffmann and Brunnemann. Based on.the data by Grandjean, etc., which dealt with levels of CO and acrolein, etc. in restaurants and other public places, conditions became totally intolerable when the smoking originated concentrations of volatile nitrosamines reached about one fourth of the data reported in the lite- rature by Hoffmann, etc., for their highest concentration in bars, etc., which were labeled as being still tolerable. Furthermore, the only other mentioning of nitro- samines at the Heidelberg ~neeting was made by Neurath, and even that in a rather limited way. Also of interest was, that the consensus of the meeting was that *the proceedings will probably be published in a few months "Oncology" ./,,

C~FIDENTIAL Dr. H. R. Bentley June II, 1979 Page two under conditions prevailing in Germany, the total nitrosamine intake is over 60% from beer, fresh meat and sausages about 15%, various cheeses about 5%, cigarette smoke about 20%, and the remainder miscellaneous. This does not, in any shape or form, consider endogenously formed nitrosamines. At present, no reliable methods are available to even provide ballpark figures, estimates varied by several hundred percent. The thrust of the meeting was - surprisingly - to underplay the role of ambient nitrosamines. For example, Schmaehl and Preussmann did propose certain limit values of the volatile nitrosamines, however, the German Govern- ment Health Ministry's authorities," including those present at that meeting, came to the conclusion that there was just not enough valid data to justify that attempt. The general feeling apparently alsp was, as mentioned above, that too much emphasis had been placed on ambient nitrosamines in the past and that the public health significance of nitrosamines - if any - would be endogenously formed nitrosamines, but nobody at the meeting was able to suggest a practical "handle" how to investigate this. Si ncerel y, FGC/ks Frank G. Colby encl osures