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WEEKLY HIGHLIGHTS BIOBEHAVIORAL RESEARCH DIVISION "Learning, undigested by thought, is labor lost/ thought, unassisted by learning, is perilous., (Confucius). Distribution: Dr. A. W. Hayes Mr. C. A. Bllxt Dr. C. R. E. Cogglns Dr. J. D. deBethlzy Dr. D. J. Doolittle Dr. C. R. Green Dr. A. T. Mosberg Dr. R. L. Suber Dr. J. H. Reynolds Biobehavloral Division Personnel (circulate)

HIGHLIGHTS DATE: September 16, 1991 Nicotine Research - Nicotine RSM - Puff Profile Analysls Status: Work continued on calculating additional puffing behavior " parametere from WAVES I and II of the Nicotine RSM Study. The new parameters will be used to augment s~w~ary date calculated at the time of smoklngs. The addltlonal parameters include puff work and power along with several indicators of puff shape. It " was also suggested at last week'~.Nicotlne RSM meeting that wlthln-clgarette puff variance be analyzed as a measure of '*smoking comfort". Significance: Additional puffing parameters are being evaluated in order to better describe smoking behavior differences between clusters. Next Steps: Recalculated data will be placed in a VAX account early next week for future analysls. Contact: DW Grlfflth (4389) Nicotine Research - Nicotine RSM - Smoking Replications Status: All of the WAVE I Full Flavor files selected for replication have been retrieved, placed on disks and reviewed. A number of the files will require some editing to remove noise and minor artifacts. Significance: The Analytical Chemistry Division will begin replicatlon of the Full Flavor smoklngs soon. Currently they are repllcating several "cleanup" files .from the FFLT group. Next Steps: Two disks (40 smokings) are ready now. The remainder will be completed next week. Contact: DW Edwards (6567), DW Griffith (4389)

Nicotine Research - Nicotine RSM - Blood Nicotine Study Status~'~stlng o£ Wave I FF smokers began subjects (12 from each of the 4 smoker "clusters") were scheduled for testing. At the end of the past week, 41 subjects had been successfully tested. Of the 48 subjects scheduled, 4 did not appear for testing and 3 were not completed for technloal reasons. The subjects remaining are distrlbutod among the 4 clusters as follows: Cluster 7; Cluster 4 - 12. A total of 135 blood samples were analyzed last week for nicotine by RIA. Significance: The Nicotine RSM Study is an integrated effort to determine the roles played by 'tar consumer acceptance of a product. The blood nicotine study may provide llnks among smoker acceptance, smoking behaviors, physlologlcal responses, and changes in blood nicotine during smoking. Next Steps: Subject testing is Scheduled through 9/27/91. Contact: JH Robinson (4976), RA Davis (4978), MF Stiles (2651) Nicotine Research - Nicotine RSM - Reports and Documentation Status: Deborah Kay, Walter Pritchard, Tom Perfettl, Pat Vestal, Harvey Gordln, Barry Fagg and Regina Brim continued to draft a chapter of the Nicotine RSM manuscript tltled "Product Preparation and Characterization". This past week, Deborah Kay compiled and reviewed the various authors' comments. Also this past week, Dr. Deborah Kay discussed the manuscript project with Chuck B11xt and gave him an outllne for the manuscript. Significance: Documentation of the Nicotine RSM will assure that the large data base from the study is applled to the Company's strategic directions. Next Steps: Regina Brim will incorporate the comments into a revised draft and distribute it to the authors. Contact: DLC Kay (5423)

Psychophysiology of Smoking Status~ £.first draft of the manuscript "Caffeine and smoking~ Subjective, performance, and psychophysiol0gical effects" was completed. The draft was distributed by first author Wally Pritchard to co-authors John Robinson, Don deBethizy, and Riley Davis for feedback. Work began on a poster titled "Effect of smoking and caffeine on EEG, heart rate, performance, and anxlety/mental alertness/muscular tension" by the same four authors. These reports summarize a study that measured EEG, heart rate, performance, subjective ratings of feeling states, smoking and breathing behavior and blood levels of nlcotln~, cotinlne, and caffeine. Subjects completed two sessions; one in which they consumed decaffelnated coffee, and another in which caffelnated coffee was drunk. Slgniflcance~ An inverse relation'between activity lh--the "fast" beta2 EEG frequency band and anxiety was found in those subjects who had high levels of trait anxiety and who had higher increases in blood nicotine on smoking. This confirmed our earller findings. Next Steps: The poster and manuscript will be submitted to the PPRC. The poster is intended for the annual convention of the Society for Psychophysiologlcal Research. The manuscript is slated to be submitted to Psychopharmacology. Contact: WS Pritchard (4388) Basic Sensory Research Status: In two unilaterally trigeminectomized (right side lesion) subjects, psychophysical and respiratory responses to propionlc acid (presented to only the nostrll on the unlesioned side) were recorded. significance~ Unilaterally trlgeminectomlzed subjects provide a unique opportunity to advance understanding of odor and irritation. Results from the normal and lesloned sides will tell what role the trigeminal nerve plays in responses to "real world" levels of chemicals in the environment. Addltionally these results help clarify interpretation of our earller research on normal and anosmlc humans. Next Steps: Testing of both subjects will be completed in October '91. Contact: JC Walker (2200)

Nicotine Research - New HNSH Status: The mechanical prototype has been disassembled by PT&D. The basel~ate has been inspected by Hr. Edwards and compared to a completed module. It appears that very little work will be required by the machine shop to update the baseplate. With minor exceptions, most of the mechanical parts to make a complete module are available. Themachtne shop has received the baseplate (and one of the Btobehavtoral modules for comparison). significance: Updating the prototype will make available the mechanical portion of a two port module quickly. This module will probably be provided to New Product Development. Next Steps: Once the machine shgp has completed the baseplate, PT&D will reassemble the mechani~bl portion of the machine. A determination of the necessary additional parts will be made. Contact: DW Grifflth (4389), DW Edwards (6567) Nicotine Research - Four-Cltles Study Status: A meeting of persons who took part In the study was held on September 12th. The status of the R&DM was reviewed and the various data sets were discussed. Participants at the meeting agreed to assist in analysis and documentation of the results. Significance: The Four-City Study obtained information on the personalities, smoking behaviors, and concepts of the "Ideal" cigarette for various clusters of full flavor non-menthol smokers. The design variables in the study were cigarette blend nicotine and draft. Documentation is needed to maximize accesslbility and use of this information. Next Steps: The group will continue to review and document results from the study. Contact: DLC Kay (5423), WA Needs (5414) Miscellaneous - John Robinson attended the American Society of Addiction Medicine's (ASAM) 4th Annual Conference on Nicotine Dependence In Raleigh on 9/13 - 9/15. The conference was primarily held for

physicians and professionals intereeted in smoking cessation programs. The presentations were extremely general and specifica~ly directed at: nicotine addiction. In reality, it was a tobacco bashing gathering of hard-core, anti-tobacco professionals. A trip report will be prepared. The article "Electroencephalographlc effects of cigarette smoking" by Wally Pritchard appeared in Psychopharmacology, Vol. 104, pp. 485-490. The artlcle "Altered EEG dynamical responsltlvlty associated with normal aging and probable Alzhelmer's disease" by Wally Pritchard, David Duke, and Kerry Coburn appear.ed in Dementia, Vol. 2, pp. 102-105. The article "Psychophyslology of N200/N400: A review and classification scheme" by Wally Prltchard, S. Shappell, and M. Brandt appeared in Advances in Psychophyslology, Vol. 4, pp. 43-106. Cindy Lyman demonstrated outstanding support of the United Way campaign by negotiating a 20% price discount on new books from Scrlbner's and then initiating efforts to collect money that eventually bought 29 books. Fourteen persons in the Biobehavloral and ETS Division contributed. Cindy received the CAT (Caught Acting Terrific) award. Also Regina Brim and Mitch Stiles assisted in the United Way Campaign for R&D by decorating the seminar room, greeting persons at the door, and handing out cards to prospective donors.