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SHOOK, HARDY ~. BACON KANSAS ~-.ITY, MISSOURI 64106 January 17, 1974 Thomas F. Ahrensfeld, Esq. DeBaun Bryant, Esq. Frederick P. Haas, Esq. Cyril F. Hetsko, Esq. Henry C. Roemer, Esq. Arthur J. Stevens, Esq. Re: L. G. S. Ran By way of supplement to previous information concerning Dro Ran, Dave Hardy has requested that I send y0a the enclosed material: Reprint from The Lancet, August 29, 1970; reprint from the British Medical Journal, December 4, 1971; article from The Guardian,.January 29, 1972; March i0, 1972, Medical World New--6-- article; undated column by Lou Kemp; and curriculum vitae. Dr. Ran is presently senior biochemist at the Glasgow and West of Scotland Regional Steroid Laboratory at the Royal Infirmary. His request for research funds amounting to about $i0,000 the first year and similar amounts in each of two suc- ceeding years received a strong endorsement from Ed Jacob, Dave Hardy and me because of the potential value of Rao's belief that lung cancer may well be an endocrine disease. He submitted an application to the CTR for a grant-in-aid to do blood steroid level research that would determine whether or not such work correlated with his earlier observations as to levels in urine. The SAB has disapproved Rao's relatively modest proposal, but Dr. SonLmers believes that Rao's basic approach is worthy for consideration as a special project. O

General Counsel January 17, .1974 Page 2 Ed Jacob has met Dr. Rao and reports that he "is a personable, obviously highly intelligent and articulate scientist." Dave has talked with several of you concerning this project and it is our understanding that support approval has been given by Brown & Williamson, Lorillard, Philip Morris and R. J. Reynq%ds. Dave may have also talked with Cy Hetsko and Fred'Haas ~'the time you get this letter. In any event, if you have any further questions with regard to Rao's theory that steroid ab~6rmalities may be "predictors" of lung cancer, we will be gla~ to try and answer them. Best personal regards. Sincerely, William W. Shinn wWs/rf Enclosures CC: Alexander Holtzman, Es~. Lester Pollack, Esq.