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The University of Vermont DEPARTMENT OF PSYCHOLOGY JOHN DEWEY HALL BURLINGTON. VERMONT 05405 August 13, 1982 Mr. Charles R. Wall, Esq. Shook, Kardy & Bacon 20th Floor, Mercantile Bank Tower Kansas City, MO 64106 Dear Chuck: As a follow-up to our telephone conversation, I am writing this letter to propose that we explore the possibility of setting up a small research activity in the Department of Psychology here at The University of Vermont. As I told you, I have discussed with Professor Rik Musty the questions related to tobacco consumption, and particularly to the questions of whether deciding to smoke, deciding to quit, difficulties in quitting -- in shor~, many of the questions we have talked about at our earlier meetings -- can be explained in terms of freedom of choice, environmental stimulation, conditioning, etc. Musty, who is Chair of our department, has been involved for a number of years in research on marijuana use, alcohol use, and the effects of social stimulation on the consumption of these substances (his curriculum vitae, enclosed, will g-lye you an idea of the work he has done in these areas~. At the moment a young faculty member, Mark Bouton is working with Rik in our animal laboratory on Valium and Librium ingestion in animals. There are a couple of other faculty members who are also knowledgeable about these matters who might be interested in c~tributing to a research effort. As a first step, I would envisage hiring a doctoral student to help us review the relevant literature around the following questions: (i) Does nicotine fit the psychopharmacological criteria of physical addidtions? (2) Does nicotine cons,tmption become a habit that is conditioned to stimuli in the environmental situations in which it is consumed? If the answer to (i) is negative, and the answer to (2) is positive, then (3) can appropriate unlearning techniques be applied in humans who decide they want to maintain a tobacco consumption-free state? I am alsb interested in questions related to the cross-cultural and social class distribution of tobacco use. Using library c~mputer search techniques available to faculty, we would prepare a literature review and analysis to determine whether or not definitive answers to these questions are available. Following this first stage, we would then prepare An Equal Opportunity Employer ZO6277qqO0

Mr. Charles R. Wall, Esq. o a report analyzing the evidence and proposing additional research that would be necessary to obtain more definitive answers to these and related questions. We would be delighted to talk with you and Pat Sirridge, and your proposal that you come to Burlington to meet the people involved seems appropriate and desirable. As a first approximation of the sort of money we are talking about for the first year, t/he standard stipend for a doctoral student, working 20 hours a week, is approximately $7,000 including tuition and fringe benefits; if several faculty members were able to invest 5% of their time (say 2 hours a week) this would come to another I0 or 12 thousand dollars a year. Our department faculty has established some years ago a non-profit educational foundation, the Psychological Research Foundation of Vermont, which can accept and disperse research monies without the large overhead required of grants made to the university. So we are talking about something around $20,000. After a year We would be in a position to discuss and propose more specific '~ands on" research projects. You will recognize that I am dictating this as an agenda item for discussion. If you and Pat decide to come to Burlington in early October~ please give me some suitable dates as soon as possible. Cordially, George W. Albee Professor GWA/hmb

Richard E. Hcs~y Education Carleton College, North~.~=1_~, ,,~inneso~a 5.:~. 79. "' ~-IcGill University, Montreal, ~uebec B.A. 1965 McGill University, Montreal Quebec P~ D 196° Psychology Psychology Psychology Honors and Fellowships Honors in independent S~udy, Carlecon-Coiiege, June 1564 £Distinction on the Comprehensive Examination, Carl~5on College, 1964 Sigma Xi, Cat'etch~oi-=o=, ~o64. USPHS Research Fellow, 1966-,96~ June Professional Developzental reading, :-~innescta 1563, Teaching Assistant, introductory Pzychology, McGill Universisy, 1964-65, 1965-66 ~ Teaching Assistsns, Moziva~io~ and Experimental Psvchology, McGi~i U~iversi~y, ]966-67 Research Scientist, ~hc [~ormel instiDuze, University of Minnesosa, June-September, 196~ Physiology, The University of Assistant Professor of Psycho~osy~ and Ver~aont, 1968-1972 Asseciate Professor of Psychology Vermont, 1973-present and Physiology, The University of Visiting Professor, Depmrtamento de Psicobiologia, Esco!a ?aulista de Medicina, Sac Paulo, Brazil, 1973-7~ Acsing Chairperson, Department of PsychologT, The bniversity of Vermont, i974-75 Chairperson, Department of Psychology, The University of Vermont, 1975-present Visiting Research Professor, Departamento de Paicobioiogia, Escoha Paulista de Medicina, Sac Paulo, Brazil (~th s fellowship from the National Re~earch Council of Brazil), June-August, 1975 Visiting Research P~-ofessor, Department of Pharmacology & Toxicology, University of Arizo.~a, Tucson, AZ, January-July 1981 Visiting Professor. DepartamenDo de Bioquimia, Universidade Federal Rio Grande do Sul, Porto Alegre Brazil, July-August 1981

Grants/Cortruccs January I)59. The University e-" Veraons. TiDie: Liubic System Modulation of "3ehe.:ior. Grant, Research Scient" -'" with Dr - E :Ch:pault, June 9"~ December 1969. Ti~,~:~.. Eff--cts_ of Li-"/~_ Diet :.[~.,~ipu" ~ions on Behavior Develcp:ze:~t-in ;h5 ~ab. U.S. Air Force ~ffi2e of Sc:.'ntie::d Research, Co-investigator ep~ember 1968 Sep ...... ,911 ~=_c: Sensory solasion, ana S.:nsor~ od_n~ in ~eha';~or Nasional Aeronausic3 end Spa~e Ad~inastra~ion Grant. Janu-:ry 197i January ~72. . fi~ie: .... :abic Sysze~ inc~rac~ions~ ~n Learning and Perfor::,ance. Faculty Research Aw~d #42. ..... -~ -o~ .... - April. ]97~_. "Y'-i~ -" Limbic System ~nteraccionc in Learni~a-S and ?er~orman%e. FaculCy Research Award ~45 (t¢ith G. Libee =:d D. ForKc4's). August ~971 - July 3~, "972. "f[cie: ¼ Self instructicn~l Course in introductory Psychology. 5 Licensed Beverages indussries. June--~971 - :-'ay "972. Ti5ie: Per~natal facto.°s in E-~ no! -~e!~ S@i~c~ion ~n Heublein Funl, August !973 - ~977. R~searcn Training in ~europsychology and Psyci~opharZacoiogy. Faculty Research Award #63, ~7-i~7£. Title: Effects of Cannabinolds on Alcohol 3ntake and Wishcraxal in Mice. Developmental Disab~ ~i~ies CoGnc~ ~ " _ . . ~± of Vermont, ~77 19"/9 Title: ~, aining of Resldenti~ ..... .-~nagers for ~..~ Developmentally Disabled. NSF Undergraduate instructional Improvemen~ Program, 1976-I}78. Title: Automation of an ~ndergraduate Psychology Laboratory. Department of Mental Health, State of Vermont Residential Managers Training Projec~, 1978-present. Gi'ant Step Research and Development Project ~97S-present. National Institute on Drug Abuse ..i~]e: Rau Model of Phencyclidine-Induced Azgressi0n (with P. C.@nsroe, Arizona) (March i952, s~mission). University of National Institute of D~ug Abuse. Title: Psychopharmac~logica! Analysis of Ansi-anxiety Effects of Cannabincids (in preparation , 9~) for submission July ~ ~ .

Papers Pa-; ame~-ers of Sidman avold_:~cc. Car!eton Ccilege, 196~. Or, the role o: ~he .,ipp.ocampus in a:_.~ :: avior :.:. A. The~_s, MeG!If Univers£ty, 1955. Effects of hlppccampa! stlmulacion ~n heart r ~e a;-~ behavior in tne ~ : . ~ om_c So~iecy, ~nizago, Octob=~ : rat Paper presente~ at P~ycho~ : ' " 1967. On zhe role of ~he Lipp~ca:apcs : :~o~ivased bch'avi~r in the ras. Effects of ~a.t~ ~n .... _- .. s o - " - - ~ c'~Lo-- ca! Asscciacio~ Cincinnacl, May, 1570. Hippocampa~ _:s~ons ~n! v!z.=~ iearn=ng w~sh dlfferen~ara:ne~ers ~- shock. Paper presented a~ Psycnonomic coc~y, S~n" ~nsonio, November, "970. Bcwes, u .... anc ,..~5=y, R.Z. Effect= of 3hock " -er. i=y performance in ~ac~ with ~: 9Docamoa" 3es~bns Pa'se~ ~cres~n~ed at Eastern Psychological Associatic.,," A3. ril, 3971. Richardson, J.S., Stacey, P.3., Cerausk's, P.W., an: Musty, R.E. Prop-ranoioi interleres wish inhibitcry behavior in ra=s. J. Phar.m Pharmacy, 197~ , P:~D~-' -" ~50 Musty, R~E.. and Chipau'..t, J.R. d'~ets cf male weaning rats. 1971, ~, 59-65. Behavioral effects Of fats in _ ~. r:~ of the ~_fe Sciences, Richardson, J.S.., Scacey, P.D., Russo, X. "., ~nd Mcsty, R.E. Effects of systemic administrasion of proprano!oi on the timing behavior (DRL-20) of rass. Archives internationales de Pharmacodynamie et de m~erapie, .... !972 " ",9,, 55-7~.~ Richardson, J.S., Suacey, P.D., Sa~by, W.R., and Musty, R.E. Effects of amygdaloid administras!on of two-beta adrenergic drugs on the ti~.:ing behavior {DRL-2C) of rain. Paper presented at Neurosci=nce Society, Houston, Texas, Oc~]gber, 1972. Musty, R.E. "Effects of Marijuana Extracts cn Brain Function and Behavior." I~viced Address: Middlebury College Winter Term Lecture Series, January !6, 1972.

Pandina. R.J., and on retention of n P~Oc.eedin.~s of the Psycholcgical As~cciat Saxby, ~.~., and Mus~y, on the accuiszion of Proceedings of the ~.E. Effects of L'~cetr~hz,..-cca,.ncblnol iv..~ avsidancc rez~n~e i.~ra'~. c ~ua~ Co::venzi~on of ~h.~- ~er_c~.n ic:~, i~73,.99~-9~2. E. Effec~ of !-2"-~e~ri]~ydrocannabl-nc.! t~o-way active avoidance response. z Annual Cenvension of 5he Amerlc~n PsychoS-• ~;~ " ..... 691 ~92 o:~a~ Assocla~ion, ~9:5, . - Musty, R.E '" E~fec cs .... jua:-a and beh~:ior zn ;he Ra ." invited :=d~r~s--: ~r_eton College • " Colloquium Series, Au-zust 29, 1373. Musty, R.E. "The Rcle of the Hippccampus in Learning, Memc.ry ana Arousal." Invited Acdre~: Carieton College Colloquium Series, August 3~, 1973. Sands, R., Anaersen, P., an/ ~{usty, R.E. A compari~on~of ~he effects of adrenerglc and Cholen@rgic blockers on ~elf stimulation• Paper presenzec a% i Cong~.~sso Lasinsmericano Psicobio!ogla. Sao Paulo, Brazil December 9-i -, ~973. Richardson, .: S , and "us~y, 2 : ;~:;, .... ~ " i • . ,-: ....... u~s on Dc~-~ ucq~:slt on of DRL-20 performance of prlprano!ol On isoprotero~ci in~ecte~ the basola~era~_ amygda~a --f~ rags Canad~=~ Jourcal of Physiology and~ ?h=rmacology, ] " ' 52 ~033 ~335. Musty, R,.E. Effects of amygc~la -e~iOns on marijuana -~nduced aggressiveness in REM sleep deprived rats. Proceelings of XV inte.'american Congress of Psychology, ~974, 143. de into the Musty, R.E., Sands, R., and Carlini, E.A. Marijuana excracc and cannabidlol lifferentiaily affect operant conditioning us a function of .depriva5ion. Paper presen%ed ac the Fourth Annual Meeting of the :~eurosclence Sociesy, St. Louis, October 20-24, 1974. Kapp, B.S., and Russo, N.J., If, and Musty, R.E. Passlye avoidance learning deficiDs produced by amygda!a lesions: relasionship with pituisary-adrenai system. PaDer p:esen~ed at Fourth Annual Meeting of the heuroscience Society, S~. Loqis, Oc%ober 20-24, 1974. Karniol, [.G., YakaLashi,~ , R.K. , and Musty, R.E. E~_cts~:~ of ~9-te~rah~drocannabinol and cannabidio" on operan% performance in rats. Archives internasiona]es de ?harmacc~,/namle et de Therapie, ~974, 212, 230-237.

on active ~vcid_nce ~cq~!.:i~ion and pas~iv;~ .~)o[.~kc~ :~c~en~~o in rats wi'~h amv6daioic ieslcn~. ~ - ..... :' 297-308. Lawson, R B , '- ~ i~ S G , anc Y.us¢~,, . ..... • . ~o_.usce . , . . " ~ E. ~" no: Dies and - Methods of Psycho"~ "" ; • ..,.,y. .~ew York Oxfor5 Un~versigy Press, ~75. Karniol, I.C., Shirakawa, --. $ Takaha":':~.:_, ...e N., .xno,~..~_, E. , a~,._ Musty, R.F.. Effects of ,~"-'ce~rahydrocann~sinol and cannabinol man. Pnn'rmacoiogy, 197~, .__~, 502-512. Carlini, E.A., Lindse,y, C.J., Mus~y, R.E., an~ Monti, J.M. :-larijuana-agressiveness in REM sPeep deprived ra;s: neuroche:nical an~ neuro-215ysiological cor.'exa;cs. - 5raude, M C and Sz-~ra S. ~Eds ) -:,.~ ~h-crmaco±o.-,: of,.~'."ri="ana New York: Rav,-n Press, :~: , ~ . Zetumer :-I G , Kap-) ~ ".-" , ":s-', ~ E and 5~isc- " ~ .... , ~r. no:-~dren~r2_c b_~ckarle in 5no a:.~yd~ala on ~et~.io~. ~o@ ~assive avoidance condi-:oning. Presented am ~he Society. for Neu:-oscience Sixth Annual ~-~eez~nS. ]976. Musty, R.E. Homeos;a~mc crivc~ and consumm;ory behavkbr: Hunger and thins5 _., zerguson, E.D , ~ivamion, a~ ~xpe-~menDa] Approach ~ew York: Ho~ ~ Pinehar~ and Winston, 1976 Must . . . ~ .... =kawa, , T~kahas~i, R.N. , and Knoebel, E. Incerac~:ons of Z9-THC a:..~-ca,':habin~TM ~r, man. in Braude, M C and Szara, ~ (Eds " ~armacc_o.'v ~f -,arij::ana New York: Raven Press, 1976, 559-564. Russ o, :'~,.J., ir, Kapp, B.S., ;.3imqu_sc, S.K., and Zusty, R.E. Passive avoidance and anygdala lesions: ..~_.~tionship with pituitary-adrena_ system. Physi~iogy and ~ehavior, 1976, 16, 191-199. Musty, R.E., Lindsey, C.J., and Carlini, E.A. 6-hydroydopa:nine the aggress£vc behavior induced by marijuana in REM sleep-deprived rats. Psychoph~rmacology, 1976, !~, 175-179. and Gallagher, M., Kapp, B.S., Musty, R.E., and Driscoll, P.A. Memory formation: Evidence for a specific neu>ochemical system in the amygdala. Science, 1977 .... 19~ .2~-42~." ~ " ~ Musty, R.E. & Sands, R. Effects of marijuana eDtrac~ distillate and ca~nabidio! on va~ble interva" performance as a function of food deprivation. Pharmacology, 1978, 1__.~5, 199-2d5. Musty, R.~.., Nero, J.P. and Masar, J. Do &eneticaily seiecsed winner and lose-, rats displayed increased aggression ~D-~r, ~.. presented at Psychonomic Society, November, 1978, San 'Antonio, Texas. N N

Musty, !i.E. , Russo, :~. J. , i-_, and Ccnneii, J.F.W.L. 5"~rcin dif.ferenr-es ~n ra-s: lrr:~ahle agg.~esslo~ : ~w.-. - ~.. Ag_~ezrahydrocannablnol and d-a:npbetm{r, ine a{'~cr ZE:4-slcep deprivation. (:'cural and Beha-vioral 31ology, it: P~ess). Musty, ~ E & Bare, J ~',. The =ra---n " e for the Human Behavior Curricu~dm Pro"5c; (in ~ceo~; Musty, R.E., :~eto, J.P. and :.:asar, J. Do genetically selected winner and lose.- rass d:saiay inccease< aggressfo-? [Submitsed for pab!ica%ion). :Zuardi, A.W., Karniol, between Archives Finkelfarb, E., Bueno, O.F.A., Xus~v, ~.c and ~ i.G. Cannabidiol effects on ciscrimiaa.t=ve responses ~.9_tetrakydrocanna~inol end c~n~-ol solution in ra~s. Int~rna~iona!ec ce ~armacod'yn.~:~i~ ~ de '~ .... ~oze, ,in Press ) . AI-Bayat~, K. and Mus'~y &9-te~vai]7.J~-ocannab.ln~_, cannao 21oi 3hi ~ionialne cn a~conoz .... ~ted fc ~ ' withCrawa in m:ce ~Su~:n~ Saxby, W.R. and Musty, R.E. inseraczions of alcchc" ~:l.c merijuan--. on human abilities: se~ ad=inis~ration zn a =oci~-$ setting. (Submit~¢.- for ~ubiica~ion). Must Must y, i.E a~A Consroe o • ?hencvc-i~-'ne produces ~." ~ ~S. "ssion in rapid eye movemenZ (REX) sleep-depri':ea .-ats. ~Sub:nisted for pubiicaDion) . y, R.E. Observazi6ns 6n publicacion). men~al nea~ uh,~ i~<~hinh- <~om=~"-ced for Must y, R'.E. , et a~.. ?h3sioiozica~_ PsycXology.,. _ .,"-~w YorK:_ ' McGraw-Hill. Inprepara5ion. Profession-io Assoc~"t~ons_- ~ American Association for the Advancement American Psychological Association Eastern Psychological Association The I~teoamerican Society of Psychology International Eeuropsychology Soclesy Sigma Xi Neurosciencc Society New York Acadeny of Sciences cf Scienc@

Consui~ans A:~ivi~ Physiological Activity ._ ....... ~,~ ~ez~avioc .:,erapy. Psychologica_ ]esearci: .:ounca~i~.n cf Vermon.:, inc. i. Depa~.uen~ of E:;,pioy:nen.s Sec~:-icy Report on "Pe;'ceived ~.na~.cia! D-sincentivez !n-~ne World of ',-:crk" wi~-: P,.B. Lawsan, June ~-972 - Septemoer 1972. :" 2 Hughes A~ Alcohol Rehabil ation Program £v~lua,~ion in : Vermont. February 1972-September 1973, Scientific .~ccivi~e~ ~s~de examiner for "4. .~opher (,.. A Thesis, "'~ • . ~.:~C-ill _';e.~si~y -- Cen:ra~ Mechani::x~ of Avoi-~-'-ce..=.. i.ea,~ning:-, ~.97: Outside cxam~.'e,- ~o:" ~. Za~de ,X. ~. T:.,~s s, :.,c~-_ ........ er~i~y -- Ethanol consumction ~nd seizure ~-:ti'/=~y pr.~pagat-.d from facsors), "~3. • • 'lational Scienc~ -o,:ncatYon Vducasio.', _rec's-~ra~ ~:ev:ew i. Stuu,=nc Oricina~ed "~" ~ o~es ( -)73) 2. instruc.:ionai Scientific Eq::ip::,6a5 3, S5ud-~ns Orig:inat..-.: S~udies (1975~ 4. Stude::s Scier. ce "frain~ng (~'975) 5. Instr~ctio,'~s: ScienDific Esu:" pment ~ 9@9) Panels Eastern .Psycho'ogical Associscion: M~y, ~73, lnv'sed Session Chai,rman I Congresso L~iname. :canao de Psicosio!ogi~, December 1973, invited Session Chairman Invited Editorial R~views for ~e ~ ~ ','~ : ., ~o~_o~,,g ~ourna!s: Science Journal of Alcohol Studies ~hysiology Biochemistry and Behavior Lif~ Sciences Journal of Abnormal Psychology Invited Reviewer Holt, Rinehart, e.~d i{~nston Oxford University Press McGraw-Hill Book Company Bradford Book~ i13~182

Und e rg re:" u.~.t a Physiological ?s',ci~o!oFy: !0 Sa~_esters (with laborazory) Physi~!oglcai ?sydhoiogy (Fscoia Paullsta de~ M~dic!nn, Sgo Pau!o, Brazil) Bio3sychology: ~ Semesters Ex.~erimentai Psychology: 8 S~m~sters (with~o~ ~ ...... ~a~uF.'). Principles of Behavior: 1 Semester Psychology in the Year 2000: 1 Semes:er (Experimenta~ Program) Principles of Educa$icn~l Evaluac.lon: i Se:ncszer (~Jx.~rim~nzal Program) -} Drugs and Psycn~pharma ~ology : 3 Graduate " *. -- Cen~.al Ner',ous System-Cortex: j Central Nervous S,;stu.-n-Corz=x. ~sco~a"" ~ P~,ulist.~ du Y,~di.: inJ:, Central Zervous Systcm-Paieocortex: Central Nervous System-Brain Stem: Visual Syster: ~wz~n R. B. Lawson): Somesthesis Cwizh W. C. Patterson): I Ser~aszer I Semester i Semester ! Ser.ester Physio~ ~ -,. ~ooy of Learning and Memory <with B. Kapp): Arousal'and Anxiety (winh J. Hasazi): Psychopharmazology: 2 Semesters 2 Semesters 1 Semester ~ ~ Physiological Basis of Sleep (with M. Gallagher): i Semester Physiological Basis of Sexual Behavior: Primaue Bei~avioc: 2 Semesters i Semester Psychopharmaco-ogy of Drugs of Abuse: } Semester - Biochemistry and Behavior: Problems in Children, Alcoholism and Drug Abuse (Universidad4 Fe~:era!, Rio Grande do Sui, Brazil) N C~ N i4