[Fragment of Critique of Study of PAHs and Respiratory Disease among Nonsmoking Women and Children in Hong Kong]

Bliley PM

[Fragment of Critique of Study of PAHs and Respiratory Disease among Nonsmoking Women and Children in Hong Kong]

Date: 01 Jan 1994
Length: 1 page
2062046120
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Abstract

Critiques unnamed study of PAH (polymaromatic hydrocarbon) exposures in secondhand smoke. Includes three bulleted points: "The lack of correlatin between pyrene and the other 6 PAH could be followed up"; "The selection of the PAH is somewhat arbitrary but acceptable in their sum as a surrogate for carcinogenic members of this chemical class"; and "Information about the interiour (e.g. furniture, surface materials) of the homes is missing". Includes table referencing IARC (International Agency for Research on Cancer) and NTP (National Toxicology Program) "claimed cigarette delivery" of various PAHs. Remarks "[these] appear...theoretically suited for the determination of the possible contribution of ETS (environmental tobacco smoke) to indoor air PAH". Includes editing in marginalia.

Fields

Type: Report; Draft material
Named Person: Voncken
Named Organization: IARC; International Agency for Research on Cancer; NTP; National Toxicology Program
Region: Hong Kong; United States; France
Additive: PAH; Polyaromatic hydrocarbons; Pyrene; Benz(a)anthracene; Benzo(k)fluoranthrene; Benzo(a)pyrene; Benzo(ghi)perylene; Benzo(b)chrysene; Dibenzo(a,e)pyrene; Pyrene
Keyword: Carcinogens; Cocarcinogens; Environmental tobacco smoke; ETS; Indoor air pollution; Mainstream smoke; MS; Mutagens; Sidestream smoke; SS; Volatile gas phase PAHs; Risk factors
Thesaurus Term: Animal subjects; Cigarettes; Diseases; Epidemiology; Government agencies; Government agencies; Health effects; Human subjects; Industry sponsored research; Research studies; Secondhand smoke; Smoke
Subject: International level; Federal level

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-T-he~nterviewing of occupants for the evaluation of external sources of indoor air pollution is y...e~ subjective and~ be ~..si~y~ replaced by objective measurements. The lack of correlation between pyrene a~the other 6 PHA could be followed up. This discrepancy (Tab. 5) could result from problems with the sample collection, and/or determination of this PAH. Also specific/sources or-~sinks'would explain the findings. " • The selection of the PAH is somewhat arbitrary but acceptable in their sum as a surrogate for carcinogenic members of this chemical class. "The selection of the PAH was based on their biological significance, carcinogenicity, and feasability of laboratory analysis." Only particulate PAH are determined, but volatile gas phase PAH may also contribute to the carcinogenic activity of indor air [????]. As shown in the table below most of them have been claimed to occur in tobacco smoke and appear therefore theoretically be suited for the determination of the possible contribution of ETS to indoor air PAH. ] be~nz(a)anthracene animal carcinogen (MAK) IARC 32: SS: 44-280 " 135 benzo(k)fl uoranth rene i~~benzo(a) pyrene animal carcinogen (MAK) IARC 32: 162 MS: 6-12 a~imal carcinogen (MAK, NTP) SS:50-140 IARC 32:211; benzo(ghi) perylene cocarcinogen (IARC?) IARC 32:MS:3-39 195; benzo(b) chrysene mutagen (carc. not tested) dibenzo(a,e)pyrene IARC 2B [IARC 32: 327;] present in TS pyrene cocarcinogen (IARC) IARC 32:431 MS: 50-270 C(a) calculated from IARC Monogrgaph No. 38, Tobacco smoking, Tab. 20 and 31 (1986) • Information about the interiour (e.g. furniture, surface materials) of the homes is missing. Indoor air composition is modulated by interaction of its components with reactive surfaces provided by furniture and decorating/building materials (e.g. Voncken et. al.~.). This information is missing in the appraoch to interpret the relatively low PAH levIIs in Hong Kong homes.

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